Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2162469627', 'doi': 'https://doi.org/10.1128/aac.3.6.662', 'title': 'Uptake of Minocycline and Tetracycline by Tetracycline-Susceptible and -Resistant Bacteria', 'display_name': 'Uptake of Minocycline and Tetracycline by Tetracycline-Susceptible and -Resistant Bacteria', 'publication_year': 1973, 'publication_date': '1973-06-01', 'ids': {'openalex': 'https://openalex.org/W2162469627', 'doi': 'https://doi.org/10.1128/aac.3.6.662', 'mag': '2162469627', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/4597735', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/444476'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.3.6.662', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc444476?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5028407899', 'display_name': 'N. A. Kuck', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'N. A. Kuck', 'raw_affiliation_strings': ['Lederle Laboratories Division, American Cyanamid Co., Pearl River, New York 10965'], 'affiliations': [{'raw_affiliation_string': 'Lederle Laboratories Division, American Cyanamid Co., Pearl River, New York 10965', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012831268', 'display_name': 'Martin Forbes', 'orcid': 'https://orcid.org/0000-0001-7775-8352'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M. Forbes', 'raw_affiliation_strings': ['Lederle Laboratories Division, American Cyanamid Co., Pearl River, New York 10965'], 'affiliations': [{'raw_affiliation_string': 'Lederle Laboratories Division, American Cyanamid Co., Pearl River, New York 10965', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.718, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.703306, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '3', 'issue': '6', 'first_page': '662', 'last_page': '664'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10506', 'display_name': 'Aquaculture disease management and microbiota', 'score': 0.9922, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10506', 'display_name': 'Aquaculture disease management and microbiota', 'score': 0.9922, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11103', 'display_name': 'Antimicrobial Peptides and Activities', 'score': 0.9749, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12673', 'display_name': 'Microbial Metabolism and Applications', 'score': 0.9671, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/minocycline', 'display_name': 'Minocycline', 'score': 0.9890431}], 'concepts': [{'id': 'https://openalex.org/C2780923616', 'wikidata': 'https://www.wikidata.org/wiki/Q193045', 'display_name': 'Tetracycline', 'level': 3, 'score': 0.9941549}, {'id': 'https://openalex.org/C2778275353', 'wikidata': 'https://www.wikidata.org/wiki/Q415336', 'display_name': 'Minocycline', 'level': 3, 'score': 0.9890431}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.7497518}, {'id': 'https://openalex.org/C2777179404', 'wikidata': 'https://www.wikidata.org/wiki/Q422442', 'display_name': 'Doxycycline', 'level': 3, 'score': 0.5301325}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.4955057}, {'id': 'https://openalex.org/C3019249092', 'wikidata': 'https://www.wikidata.org/wiki/Q274493', 'display_name': 'Antibacterial agent', 'level': 3, 'score': 0.45100135}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.45098197}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.445559}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.44215}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.083844274}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.036816984}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004352', 'descriptor_name': 'Drug Resistance, Microbial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D013210', 'descriptor_name': 'Staphylococcus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D013752', 'descriptor_name': 'Tetracycline', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008911', 'descriptor_name': 'Minocycline', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008911', 'descriptor_name': 'Minocycline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013210', 'descriptor_name': 'Staphylococcus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013210', 'descriptor_name': 'Staphylococcus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013752', 'descriptor_name': 'Tetracycline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.3.6.662', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc444476', 'pdf_url': 'https://europepmc.org/articles/pmc444476?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC444476', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/4597735', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc444476', 'pdf_url': 'https://europepmc.org/articles/pmc444476?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1530240813', 'https://openalex.org/W1587654216', 'https://openalex.org/W1798613294', 'https://openalex.org/W1801241344', 'https://openalex.org/W1840105012', 'https://openalex.org/W1978004777', 'https://openalex.org/W2029805742', 'https://openalex.org/W2030218993', 'https://openalex.org/W2033295228', 'https://openalex.org/W2049507643', 'https://openalex.org/W2057090099', 'https://openalex.org/W2079996719', 'https://openalex.org/W2089775329', 'https://openalex.org/W2143596481', 'https://openalex.org/W2161240154', 'https://openalex.org/W2227350184', 'https://openalex.org/W2321909935', 'https://openalex.org/W2323298726', 'https://openalex.org/W2407654553', 'https://openalex.org/W2407757309', 'https://openalex.org/W2471307149', 'https://openalex.org/W4240522011'], 'related_works': ['https://openalex.org/W2472109262', 'https://openalex.org/W2397128682', 'https://openalex.org/W2162469627', 'https://openalex.org/W2155663431', 'https://openalex.org/W2135706410', 'https://openalex.org/W2132244862', 'https://openalex.org/W2106599793', 'https://openalex.org/W2029805742', 'https://openalex.org/W2026623915', 'https://openalex.org/W1985435370'], 'abstract_inverted_index': {'Minocycline': [0], '(7-dimethylamino-6-demethyl-6-deoxytetracycline)': [1], 'is': [2, 78, 82], 'a': [3], 'new': [4], 'semisynthetic': [5], 'tetracycline': [6], 'with': [7], 'potent': [8], 'activity': [9, 16, 28], 'against': [10, 17, 84], 'tetracycline-susceptible': [11], 'bacterial': [12], 'pathogens': [13], 'and': [14, 46, 66], 'unique': [15, 27], 'tetracycline-resistant': [18, 32, 45, 57, 85], 'staphylococci.': [19], 'Studies': [20], 'to': [21, 64, 91, 96], 'determine': [22], 'the': [23, 40, 44, 74, 93], 'basis': [24], 'for': [25], 'this': [26], 'showed': [29], 'that,': [30], 'whereas': [31], 'staphylococci': [33, 86], 'took': [34], 'up': [35], 'less': [36, 68], '3': [37], 'H-tetracycline': [38], 'than': [39, 72], 'susceptible': [41, 75], 'cells,': [42], 'both': [43, 70], '-susceptible': [47], 'cells': [48, 60, 94], 'accumulated': [49, 67], 'equivalent': [50], 'amounts': [51], 'of': [52, 69, 88], '14': [53], 'C-minocycline.': [54], 'In': [55], 'contrast,': [56], 'Escherichia': [58], 'coli': [59], 'were': [61], 'relatively': [62], 'resistant': [63], 'minocycline': [65, 81], 'drugs': [71], 'did': [73], 'organisms.': [76], 'It': [77], 'proposed': [79], 'that': [80], 'effective': [83], 'because': [87], 'its': [89], 'ability': [90], 'penetrate': [92], 'sufficiently': [95], 'reach': [97], 'inhibiting': [98], 'concentrations': [99], 'at': [100], 'sensitive': [101], 'reaction': [102], 'sites.': [103]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2162469627', 'counts_by_year': [{'year': 2017, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-14T11:56:41.215183', 'created_date': '2016-06-24'}