Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2162390635', 'doi': 'https://doi.org/10.1101/lm.6.3.284', 'title': 'BDNF Regulates the Intrinsic Excitability of Cortical Neurons', 'display_name': 'BDNF Regulates the Intrinsic Excitability of Cortical Neurons', 'publication_year': 1999, 'publication_date': '1999-05-01', 'ids': {'openalex': 'https://openalex.org/W2162390635', 'doi': 'https://doi.org/10.1101/lm.6.3.284', 'mag': '2162390635', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10492010', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/311300'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/lm.6.3.284', 'pdf_url': 'http://learnmem.cshlp.org/content/6/3/284.full.pdf', 'source': {'id': 'https://openalex.org/S73374563', 'display_name': 'Learning & Memory', 'issn_l': '1072-0502', 'issn': ['1072-0502', '1549-5485'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://learnmem.cshlp.org/content/6/3/284.full.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5036263686', 'display_name': 'Niraj S. Desai', 'orcid': 'https://orcid.org/0000-0002-9969-5206'}, 'institutions': [{'id': 'https://openalex.org/I6902469', 'display_name': 'Brandeis University', 'ror': 'https://ror.org/05abbep66', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I6902469']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Niraj S. Desai', 'raw_affiliation_strings': ['Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454-9110 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454-9110 USA', 'institution_ids': ['https://openalex.org/I6902469']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081234527', 'display_name': 'Lana C. Rutherford', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I6902469', 'display_name': 'Brandeis University', 'ror': 'https://ror.org/05abbep66', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I6902469']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lana C. Rutherford', 'raw_affiliation_strings': ['Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454-9110 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454-9110 USA', 'institution_ids': ['https://openalex.org/I6902469']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5063639195', 'display_name': 'Gina G. Turrigiano', 'orcid': 'https://orcid.org/0000-0002-4476-4059'}, 'institutions': [{'id': 'https://openalex.org/I6902469', 'display_name': 'Brandeis University', 'ror': 'https://ror.org/05abbep66', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I6902469']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gina G. Turrigiano', 'raw_affiliation_strings': ['Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454-9110 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454-9110 USA', 'institution_ids': ['https://openalex.org/I6902469']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.726, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 197, 'citation_normalized_percentile': {'value': 0.9471, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '6', 'issue': '3', 'first_page': '284', 'last_page': '291'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10608', 'display_name': 'Neurogenesis and neuroplasticity mechanisms', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/premovement-neuronal-activity', 'display_name': 'Premovement neuronal activity', 'score': 0.43839118}], 'concepts': [{'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.8563126}, {'id': 'https://openalex.org/C160539049', 'wikidata': 'https://www.wikidata.org/wiki/Q3064187', 'display_name': 'Neurotrophic factors', 'level': 3, 'score': 0.59220815}, {'id': 'https://openalex.org/C127445978', 'wikidata': 'https://www.wikidata.org/wiki/Q187181', 'display_name': 'Synapse', 'level': 2, 'score': 0.57223237}, {'id': 'https://openalex.org/C2778790584', 'wikidata': 'https://www.wikidata.org/wiki/Q123045', 'display_name': 'Brain-derived neurotrophic factor', 'level': 4, 'score': 0.53701293}, {'id': 'https://openalex.org/C92020748', 'wikidata': 'https://www.wikidata.org/wiki/Q420457', 'display_name': 'Neurotrophin', 'level': 3, 'score': 0.5064496}, {'id': 'https://openalex.org/C97124661', 'wikidata': 'https://www.wikidata.org/wiki/Q14897782', 'display_name': 'Tropomyosin receptor kinase B', 'level': 4, 'score': 0.49071348}, {'id': 'https://openalex.org/C160268369', 'wikidata': 'https://www.wikidata.org/wiki/Q295251', 'display_name': 'AMPA receptor', 'level': 4, 'score': 0.45912373}, {'id': 'https://openalex.org/C98229152', 'wikidata': 'https://www.wikidata.org/wiki/Q1551556', 'display_name': 'Synaptic plasticity', 'level': 3, 'score': 0.45050693}, {'id': 'https://openalex.org/C74254510', 'wikidata': 'https://www.wikidata.org/wiki/Q7240508', 'display_name': 'Premovement neuronal activity', 'level': 2, 'score': 0.43839118}, {'id': 'https://openalex.org/C2778468042', 'wikidata': 'https://www.wikidata.org/wiki/Q273976', 'display_name': 'Blockade', 'level': 3, 'score': 0.4147861}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.36316282}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.30888402}, {'id': 'https://openalex.org/C67018056', 'wikidata': 'https://www.wikidata.org/wiki/Q414896', 'display_name': 'NMDA receptor', 'level': 3, 'score': 0.18218967}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.156975}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019208', 'descriptor_name': 'Brain-Derived Neurotrophic Factor', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001923', 'descriptor_name': 'Brain Chemistry', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001923', 'descriptor_name': 'Brain Chemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019208', 'descriptor_name': 'Brain-Derived Neurotrophic Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019208', 'descriptor_name': 'Brain-Derived Neurotrophic Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004594', 'descriptor_name': 'Electrophysiology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008564', 'descriptor_name': 'Membrane Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008564', 'descriptor_name': 'Membrane Potentials', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009473', 'descriptor_name': 'Neuronal Plasticity', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009473', 'descriptor_name': 'Neuronal Plasticity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018408', 'descriptor_name': 'Patch-Clamp Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D013779', 'descriptor_name': 'Tetrodotoxin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013779', 'descriptor_name': 'Tetrodotoxin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014793', 'descriptor_name': 'Visual Cortex', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D014793', 'descriptor_name': 'Visual Cortex', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D014793', 'descriptor_name': 'Visual Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018350', 'descriptor_name': 'alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D018350', 'descriptor_name': 'alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/lm.6.3.284', 'pdf_url': 'http://learnmem.cshlp.org/content/6/3/284.full.pdf', 'source': {'id': 'https://openalex.org/S73374563', 'display_name': 'Learning & Memory', 'issn_l': '1072-0502', 'issn': ['1072-0502', '1549-5485'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10492010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/lm.6.3.284', 'pdf_url': 'http://learnmem.cshlp.org/content/6/3/284.full.pdf', 'source': {'id': 'https://openalex.org/S73374563', 'display_name': 'Learning & Memory', 'issn_l': '1072-0502', 'issn': ['1072-0502', '1549-5485'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315909', 'host_organization_name': 'Cold Spring Harbor Laboratory Press', 'host_organization_lineage': ['https://openalex.org/P4310315909'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1482683088', 'https://openalex.org/W1514853588', 'https://openalex.org/W1572568267', 'https://openalex.org/W1865428056', 'https://openalex.org/W1901043290', 'https://openalex.org/W1971156703', 'https://openalex.org/W1973918689', 'https://openalex.org/W1979896676', 'https://openalex.org/W1989053030', 'https://openalex.org/W1993482929', 'https://openalex.org/W2009490317', 'https://openalex.org/W2010741244', 'https://openalex.org/W2011436061', 'https://openalex.org/W2011663144', 'https://openalex.org/W2016770416', 'https://openalex.org/W2032054534', 'https://openalex.org/W2036512556', 'https://openalex.org/W2038702076', 'https://openalex.org/W2041414140', 'https://openalex.org/W2046550620', 'https://openalex.org/W2053317975', 'https://openalex.org/W2054595326', 'https://openalex.org/W2056661320', 'https://openalex.org/W2059010387', 'https://openalex.org/W2062910236', 'https://openalex.org/W2063062105', 'https://openalex.org/W2063360367', 'https://openalex.org/W2066781880', 'https://openalex.org/W2069527370', 'https://openalex.org/W2070950696', 'https://openalex.org/W2089175380', 'https://openalex.org/W2089309198', 'https://openalex.org/W2096519870', 'https://openalex.org/W2106959797', 'https://openalex.org/W2113122815', 'https://openalex.org/W2126846442', 'https://openalex.org/W2130464434', 'https://openalex.org/W2133473629', 'https://openalex.org/W2157238829', 'https://openalex.org/W2159117162', 'https://openalex.org/W2177386801', 'https://openalex.org/W2485025477'], 'related_works': ['https://openalex.org/W56018094', 'https://openalex.org/W3021434253', 'https://openalex.org/W2154977175', 'https://openalex.org/W2095302115', 'https://openalex.org/W2090228900', 'https://openalex.org/W2087696642', 'https://openalex.org/W2066790769', 'https://openalex.org/W2063728359', 'https://openalex.org/W2007837302', 'https://openalex.org/W1997405480'], 'abstract_inverted_index': {'Neocortical': [0], 'pyramidal': [1, 83], 'neurons': [2], 'respond': [3], 'to': [4, 17, 21, 172, 174], 'prolonged': [5], 'activity': [6, 88], 'blockade': [7], 'by': [8, 87], 'modulating': [9], 'their': [10], 'balance': [11], 'of': [12, 28, 35, 50, 91, 122, 131, 135, 145, 162], 'inward': [13], 'and': [14, 74, 164], 'outward': [15], 'currents': [16], 'become': [18], 'more': [19], 'sensitive': [20], 'synaptic': [22, 137, 163], 'input,': [23], 'possibly': [24], 'as': [25, 142], 'a': [26, 75, 101, 119, 143, 159], 'means': [27], 'homeostatically': [29], 'regulating': [30, 108], 'firing': [31], 'rates': [32], 'during': [33], 'periods': [34], 'intense': [36], 'change': [37, 81], 'in': [38, 82, 97, 107, 126, 177], 'synapse': [39], 'number': [40], 'or': [41, 140], 'strength.': [42], 'Here': [43], 'we': [44, 68], 'show': [45], 'that': [46, 70, 116, 152], 'this': [47], 'activity-dependent': [48], 'regulation': [49, 161], 'intrinsic': [51, 165], 'excitability': [52, 85], 'depends': [53], 'on': [54, 63], 'the': [55, 80, 132, 156], 'neurotrophin': [56], 'brain-derived': [57], 'neurotrophic': [58], 'factor': [59], '(BDNF).': [60], 'In': [61], 'experiments': [62], 'rat': [64], 'visual': [65], 'cortical': [66, 170], 'cultures,': [67], 'found': [69], 'exogenous': [71], 'BDNF': [72, 106, 117, 153], 'prevented,': [73], 'TrkB-IgG': [76], 'fusion': [77], 'protein': [78], 'reproduced,': [79], 'neuron': [84], 'produced': [86], 'blockade.': [89], 'Most': [90], 'these': [92, 127, 149], 'effects': [93], 'were': [94], 'also': [95], 'observed': [96], 'bipolar': [98], 'interneurons,': [99], 'indicating': [100], 'very': [102], 'general': [103], 'role': [104], 'for': [105], 'neuronal': [109], 'excitability.': [110], 'Moreover,': [111], 'earlier': [112], 'work': [113], 'has': [114], 'demonstrated': [115], 'mediates': [118], 'different': [120], 'kind': [121], 'homeostatic': [123], 'plasticity': [124], 'present': [125], 'same': [128], 'cultures:': [129], 'scaling': [130], 'quantal': [133], 'amplitude': [134], 'AMPA-mediated': [136], 'inputs': [138], 'up': [139], 'down': [141], 'function': [144], 'activity.': [146, 178], 'Taken': [147], 'together,': [148], 'results': [150], 'suggest': [151], 'may': [154], 'be': [155], 'signal': [157], 'controlling': [158], 'coordinated': [160], 'properties': [166], 'aimed': [167], 'at': [168], 'allowing': [169], 'networks': [171], 'adapt': [173], 'long-lasting': [175], 'changes': [176]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2162390635', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2025-01-12T19:10:28.044965', 'created_date': '2016-06-24'}