Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2162320799', 'doi': 'https://doi.org/10.1128/jvi.67.8.4605-4610.1993', 'title': 'Viral determinants of age-dependent virulence of Sindbis virus for mice', 'display_name': 'Viral determinants of age-dependent virulence of Sindbis virus for mice', 'publication_year': 1993, 'publication_date': '1993-08-01', 'ids': {'openalex': 'https://openalex.org/W2162320799', 'doi': 'https://doi.org/10.1128/jvi.67.8.4605-4610.1993', 'mag': '2162320799', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8392602', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/237845'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.67.8.4605-4610.1993', 'pdf_url': 'https://jvi.asm.org/content/jvi/67/8/4605.full.pdf', 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://jvi.asm.org/content/jvi/67/8/4605.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010737941', 'display_name': 'P C Tucker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P C Tucker', 'raw_affiliation_strings': ['Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.', 'institution_ids': ['https://openalex.org/I2799853436', 'https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004573813', 'display_name': 'Ellen G. Strauss', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'E G Strauss', 'raw_affiliation_strings': ['Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.', 'institution_ids': ['https://openalex.org/I2799853436', 'https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069864999', 'display_name': 'Richard Kühn', 'orcid': 'https://orcid.org/0000-0003-4148-1026'}, 'institutions': [{'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R J Kuhn', 'raw_affiliation_strings': ['Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.', 'institution_ids': ['https://openalex.org/I2799853436', 'https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029767823', 'display_name': 'J H Strauss', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J H Strauss', 'raw_affiliation_strings': ['Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.', 'institution_ids': ['https://openalex.org/I2799853436', 'https://openalex.org/I145311948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5040754947', 'display_name': 'Diane E. Griffin', 'orcid': 'https://orcid.org/0000-0001-6643-2429'}, 'institutions': [{'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'D E Griffin', 'raw_affiliation_strings': ['Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.', 'institution_ids': ['https://openalex.org/I2799853436', 'https://openalex.org/I145311948']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.655, 'has_fulltext': False, 'cited_by_count': 99, 'citation_normalized_percentile': {'value': 0.94806, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '67', 'issue': '8', 'first_page': '4605', 'last_page': '4610'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10625', 'display_name': 'Herpesviruses: Epidemiology, Pathogenesis, and Management', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10625', 'display_name': 'Herpesviruses: Epidemiology, Pathogenesis, and Management', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10112', 'display_name': 'Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11581', 'display_name': 'Ebola Virus Research and Outbreaks', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sindbis-virus', 'display_name': 'Sindbis virus', 'score': 0.7619705}, {'id': 'https://openalex.org/keywords/weanling', 'display_name': 'Weanling', 'score': 0.49035978}, {'id': 'https://openalex.org/keywords/encephalitis', 'display_name': 'Encephalitis', 'score': 0.45886}, {'id': 'https://openalex.org/keywords/viremia', 'display_name': 'Viremia', 'score': 0.44882306}], 'concepts': [{'id': 'https://openalex.org/C60987743', 'wikidata': 'https://www.wikidata.org/wiki/Q1460232', 'display_name': 'Virulence', 'level': 3, 'score': 0.95103323}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.81604457}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.8148751}, {'id': 'https://openalex.org/C2777343345', 'wikidata': 'https://www.wikidata.org/wiki/Q2302993', 'display_name': 'Sindbis virus', 'level': 4, 'score': 0.7619705}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.70611584}, {'id': 'https://openalex.org/C2778433245', 'wikidata': 'https://www.wikidata.org/wiki/Q7978039', 'display_name': 'Weanling', 'level': 2, 'score': 0.49035978}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.4650897}, {'id': 'https://openalex.org/C2776185481', 'wikidata': 'https://www.wikidata.org/wiki/Q1425304', 'display_name': 'Viremia', 'level': 3, 'score': 0.44882306}, {'id': 'https://openalex.org/C2780868878', 'wikidata': 'https://www.wikidata.org/wiki/Q1660197', 'display_name': 'Immunogenicity', 'level': 3, 'score': 0.44779348}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.2745567}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.15490207}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.099056065}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.09329742}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.08020896}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': True}, {'descriptor_ui': 'D004660', 'descriptor_name': 'Encephalitis', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D012845', 'descriptor_name': 'Sindbis Virus', 'qualifier_ui': 'Q000472', 'qualifier_name': 'pathogenicity', 'is_major_topic': True}, {'descriptor_ui': 'D014036', 'descriptor_name': 'Togaviridae Infections', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000831', 'descriptor_name': 'Animals, Newborn', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004279', 'descriptor_name': 'DNA, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004279', 'descriptor_name': 'DNA, Viral', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004279', 'descriptor_name': 'DNA, Viral', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D004660', 'descriptor_name': 'Encephalitis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004660', 'descriptor_name': 'Encephalitis', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008815', 'descriptor_name': 'Mice, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009838', 'descriptor_name': 'Oligodeoxyribonucleotides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011995', 'descriptor_name': 'Recombination, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012845', 'descriptor_name': 'Sindbis Virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012845', 'descriptor_name': 'Sindbis Virus', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D012845', 'descriptor_name': 'Sindbis Virus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014036', 'descriptor_name': 'Togaviridae Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014774', 'descriptor_name': 'Virulence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014774', 'descriptor_name': 'Virulence', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.67.8.4605-4610.1993', 'pdf_url': 'https://jvi.asm.org/content/jvi/67/8/4605.full.pdf', 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc237845', 'pdf_url': 'https://europepmc.org/articles/pmc237845?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC237845', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://resolver.caltech.edu/CaltechAUTHORS:20160411-161010078', 'pdf_url': 'https://authors.library.caltech.edu/records/m41zq-gf512/files/J._Virol.-1993-Tucker-4605-10.pdf?download=1', 'source': {'id': 'https://openalex.org/S4306402162', 'display_name': 'CaltechAUTHORS (California Institute of Technology)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I122411786', 'host_organization_name': 'California Institute of Technology', 'host_organization_lineage': ['https://openalex.org/I122411786'], 'host_organization_lineage_names': ['California Institute of Technology'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8392602', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/jvi.67.8.4605-4610.1993', 'pdf_url': 'https://jvi.asm.org/content/jvi/67/8/4605.full.pdf', 'source': {'id': 'https://openalex.org/S96615428', 'display_name': 'Journal of Virology', 'issn_l': '0022-538X', 'issn': ['0022-538X', '1070-6321', '1098-5514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.6, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1517159675', 'https://openalex.org/W1534806564', 'https://openalex.org/W1591803019', 'https://openalex.org/W1708365360', 'https://openalex.org/W1804292265', 'https://openalex.org/W1815651224', 'https://openalex.org/W1899341523', 'https://openalex.org/W1904248154', 'https://openalex.org/W1959644357', 'https://openalex.org/W1969270121', 'https://openalex.org/W1975744697', 'https://openalex.org/W1988256009', 'https://openalex.org/W1988598654', 'https://openalex.org/W2003206650', 'https://openalex.org/W2007571905', 'https://openalex.org/W2010271751', 'https://openalex.org/W2011275029', 'https://openalex.org/W2022778181', 'https://openalex.org/W2023734389', 'https://openalex.org/W2036931150', 'https://openalex.org/W2049449836', 'https://openalex.org/W2051895384', 'https://openalex.org/W2064824796', 'https://openalex.org/W2089353787', 'https://openalex.org/W2090979857', 'https://openalex.org/W2119889845', 'https://openalex.org/W2124474821', 'https://openalex.org/W2130110983', 'https://openalex.org/W2158364751', 'https://openalex.org/W2162707932', 'https://openalex.org/W2169180468', 'https://openalex.org/W2172185783', 'https://openalex.org/W2419053233', 'https://openalex.org/W2483389645', 'https://openalex.org/W257578036', 'https://openalex.org/W4290353569', 'https://openalex.org/W9980252'], 'related_works': ['https://openalex.org/W3012126176', 'https://openalex.org/W2390466453', 'https://openalex.org/W2382982235', 'https://openalex.org/W2360291613', 'https://openalex.org/W2353012055', 'https://openalex.org/W2349316009', 'https://openalex.org/W2255018107', 'https://openalex.org/W2047712879', 'https://openalex.org/W1599019727', 'https://openalex.org/W1582252177'], 'abstract_inverted_index': {'Many': [0], 'alphaviruses': [1], 'cause': [2], 'more': [3, 123, 255], 'severe': [4, 17], 'disease': [5, 18], 'in': [6, 10, 50, 56, 69, 175, 208, 261, 269, 274, 286], 'young': [7], 'animals': [8], 'than': [9, 128], 'older': [11, 154, 287], 'animals.': [12, 41], 'The': [13], 'age-dependent': [14], 'resistance': [15, 38], 'to': [16, 249, 258], 'is': [19, 282], 'determined': [20], 'primarily': [21], 'by': [22, 291], 'maturation': [23], 'of': [24, 29, 39, 64, 84, 156, 161, 201, 231, 264, 295], 'the': [25, 36, 81, 148, 183, 191, 199, 202, 212, 232, 262, 293], 'host,': [26], 'but': [27, 190], 'strains': [28], 'virus': [30, 43, 296], 'can': [31], 'be': [32], 'selected': [33], 'that': [34, 80, 116, 280], 'overcome': [35], 'increased': [37], 'mature': [40], 'Sindbis': [42], '(SV)': [44], 'strain': [45, 63], 'AR339': [46, 89], 'causes': [47, 66], 'fatal': [48, 67], 'encephalitis': [49, 55, 68], 'newborn': [51, 74, 126, 152, 188], 'mice': [52, 127, 155, 288], 'and': [53, 107, 115, 137, 153, 180, 196, 204, 226, 257, 266, 273, 289], 'nonfatal': [54], 'weanling': [57, 70], 'mice,': [58, 189, 225, 244, 268], 'whereas': [59, 88], 'NSV,': [60], 'a': [61, 159], 'neuroadapted': [62], 'SV,': [65], 'as': [71, 73], 'well': [72], 'mice.': [75], 'We': [76], 'have': [77], 'previously': [78], 'shown': [79], 'E2': [82, 90, 119, 131, 166], 'glycoprotein': [83], 'NSV': [85], 'contained': [86], 'His-55,': [87], 'had': [91], 'Gln-55': [92], '(S.': [93], 'Lustig,': [94], 'A.': [95], 'C.': [96, 98, 135], 'Jackson,': [97], 'S.': [99], 'Hahn,': [100], 'D.': [101, 138], 'E.': [102, 104, 139], 'Griffin,': [103, 140], 'G.': [105], 'Strauss,': [106, 110], 'J.': [108, 111, 141], 'H.': [109], 'Virol.': [112, 142], '62:2329-2336,': [113], '1988)': [114], 'SV': [117, 129, 157], 'with': [118, 130, 177, 218, 238, 252], 'containing': [120, 132, 158], 'Gly-172': [121, 179], 'was': [122, 229, 240], 'virulent': [124, 186, 222, 241], 'for': [125, 150, 187, 223, 242, 284], 'Arg-172': [133], '(P.': [134], 'Tucker': [136], '65:1551-1557,': [143], '1991).': [144], 'Here': [145], 'we': [146], 'tested': [147], 'virulence': [149, 200, 209, 228], 'both': [151, 178, 194], 'number': [160], 'different': [162], 'amino': [163], 'acids': [164], 'at': [165, 193, 234], 'position': [167, 235], '55': [168, 195], '(His,': [169], 'Gln,': [170], 'Lys,': [171], 'Arg,': [172], 'Glu,': [173], 'Gly)': [174], 'combination': [176], 'Arg-172.': [181], 'All': [182], 'viruses': [184, 217], 'were': [185, 206, 220], 'residues': [192], '172': [197], 'influenced': [198], 'virus,': [203], 'there': [205], 'differences': [207], 'observed': [210], 'among': [211], 'various': [213], 'viruses.': [214], 'However,': [215], 'only': [216], 'His-55': [219, 253, 281], 'fully': [221], '14-day-old': [224, 267], 'this': [227], 'independent': [230], 'residue': [233], '172.': [236], 'Virus': [237], 'Lys-55': [239], '7-day-old': [243], 'although': [245], 'slightly': [246], 'attenuated': [247], 'relative': [248], 'His-55.': [250], 'Viruses': [251], 'grew': [254], 'rapidly': [256], 'higher': [259], 'titer': [260], 'brains': [263], '7-': [265], 'N18': [270], 'neuroblastoma': [271], 'cells,': [272], 'BHK': [275], 'cells.': [276], 'Our': [277], 'data': [278], 'suggest': [279], 'important': [283], 'neurovirulence': [285], 'acts': [290], 'increasing': [292], 'efficiency': [294], 'replication.': [297]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2162320799', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-01T04:30:30.381502', 'created_date': '2016-06-24'}