Publication Information

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'clinically': [111], 'meaningful': [112], 'disease': [113, 1169], 'progression': [114, 123, 267, 1170], 'despite': [115], 'optimal': [116], 'current': [117, 1083], 'therapy.Although': [118], 'biological': [120], 'mechanisms': [121, 2645], 'for': [122, 445, 498, 535, 685, 753, 1100, 1314, 1318, 2458, 2717, 3579, 3781], 'ventricular': [125, 139, 251, 928, 1551, 1695, 1870, 1977, 2168, 3861], 'remodeling': [126, 1552], 'yet': [128], 'be': [130, 174, 286, 300, 327, 567, 801, 894, 1070, 1113, 1286], 'definitively': [131, 1090], 'explained,': [132], 'mounting': [133], 'evidence': [134, 905, 1086], 'supports': [135], 'theory': [137], 'dysfunction': [140, 393, 1268, 1696, 2243, 2560, 2885, 3491], 'worsens': [141], 'as': [142, 309, 389, 632, 698, 956, 1220, 1222, 1302, 1828, 1833, 2455], 'a': [143, 273, 495, 544, 593, 626, 699, 747, 812, 816, 854, 931, 944, 957, 1006, 1096, 1129, 1183, 1195, 1262, 1347, 1616, 1691, 1783, 1819, 1829, 1834, 2061, 2282, 2292, 2456, 2849, 3782], 'consequence': [144], 'increased': [146, 742], 'reactive': [147, 1820], 'oxygen': [148, 986, 1787, 1821, 1908, 2030], 'species': [149, 1822], '(ROS)': [150], 'formation,': [151], 'which': [152, 381, 482, 769, 2024], 'turn': [154, 771], 'promotes': [155, 860], 'myocyte': [156, 1178, 1213, 1232, 1612, 2158], 'apoptosis.3': [157], 'Myocyte': [158, 2152], 'apoptosis': [159, 205, 263, 282, 355, 405, 423, 499, 564, 762, 773, 868, 889, 1077, 1094, 1110, 1127, 1191, 1549, 1653, 1998, 2210, 2238, 2328, 2565, 2644, 2977, 3468, 3522, 3812], 'observed': [161], 'numerous': [163], 'pathological': [164], 'situations': [165], 'including': [166, 226], 'cardiomyopathy,4': [167], 'ischemia,5': [168], 'transplant': [170], 'rejection6': [171], 'can': [173, 1159, 1826], 'induced': [175, 1999, 2165, 2680, 3819], 'experimentally': [176], 'agonists7': [179], 'or': [180, 313, 321, 486, 560, 760, 1230, 1332, 2070], 'direct': [181], 'generation': [182, 694], 'superoxide.8In': [184], 'this': [185, 396, 435, 678, 898, 939, 1323], 'issue': [186], 'Circulation': [188, 3267], 'Research,': [189, 2622, 3268, 3669], 'Cesselli': [190, 343, 1236, 1667], 'et': [191, 344, 783, 1237], 'al9': [192, 345, 1238], 'examined': [194], 'linkage': [196, 899, 1007], 'between': [197, 1008, 1076, 1177], 'pathways': [198, 225, 352, 386], 'involved': [199, 235], 'mediating': [201], 'oxidative': [202, 279, 332, 362, 715, 851, 907, 949, 1029, 1092, 1225, 1253, 1730, 2001, 2207, 2324, 2647, 2888, 2979, 3008, 3046, 3220, 3461, 3530, 3616, 3858], 'metabolism': [203, 892, 913], 'dogs': [207, 1915, 1950], 'pacing-induced': [209, 289, 1917, 1952], 'dilated': [210, 1701], 'cardiomyopathy.': [211, 1524, 1702], 'Using': [212], 'both': [213, 480, 980, 989, 1028], 'immunohistochemistry': [214], 'immunoblotting': [216], 'techniques,': [217], 'authors': [219], 'track': [220], 'changes': [221, 245], 'multiple': [223, 375], 'apoptotic': [224, 488, 550, 3011, 3178], 'caspases,': [228], 'mitochondrial': [229, 531, 671, 730, 873, 1009, 1017, 1034, 1061, 2559, 3490, 3550], 'cytochrome': [230, 471, 536, 610, 616, 767, 806, 832, 1514], 'c': [231, 472, 537, 611, 617, 624, 807, 833, 1515, 1813], 'release,': [232], 'proteins': [234], 'DNA': [237, 3047, 3134, 3147, 3898], 'damage': [238, 333, 3135, 3384, 3899], '(see': [239, 621], 'Figure).': [240, 622], 'Importantly,': [241], 'induction': [242], 'these': [244, 385, 754, 1308], 'precedes': [246], 'left': [250, 1869, 1976], '(LV)': [252], 'dysfunction,': [253], 'providing': [254], 'additional': [255, 1003], 'strong': [256, 904], 'support,': [257], 'but': [258, 1058], 'not': [259, 402, 1049, 1112, 1165, 1326], 'definitive': [260], 'proof,': [261], 'participates': [264], 'LV': [269, 392, 1102, 1124, 1267], 'remodeling.': [270], 'In': [271, 570, 938, 1182, 1282], 'addition,': [272, 1283], 'new': [274], 'signaling': [275, 351, 379, 1298, 2239], 'molecule,': [276], 'p66shc,': [277, 479], 'linking': [278, 353], 'stress': [280, 908, 950, 1226, 1254, 1731, 2002, 2208, 2648, 2889, 3009, 3221, 3617, 3859], 'demonstrated': [284], 'upregulated': [287], 'HF.10': [290], 'p66shc': [291, 320, 1242, 1726], 'an': [293, 407, 416, 582, 633, 655, 786, 1175, 2935], 'oxidant': [294, 1297], 'stress–induced,': [295], 'proapoptotic': [296, 378, 508], 'proto-oncogene': [297, 1241], 'known': [298], 'activated': [301, 388, 515], 'by': [302, 342, 516, 554, 592, 599, 658, 688, 819, 979, 1235, 1296, 1341, 2000, 2023, 2166, 2462, 2557, 2608, 2886, 2933, 2975, 3144, 3528, 3820], 'phosphorylation': [303, 716], 'response': [305, 1732, 1944, 1969], 'stimuli': [307], 'such': [308, 1301], 'H2O2,': [310], 'UV': [311], 'radiation,': [312], 'epidermal': [314], 'growth': [315], 'factor.': [316], 'Transgenic': [317], 'disruption': [318], 'inactivation': [322], 'its': [324, 555, 2065], 'ability': [325, 358, 1010], 'phosphorylated': [328], 'confers': [329], 'resistance': [330], 'prolongs': [335], 'life': [336, 1734], 'mice.10': [338], 'The': [339, 364, 645, 736, 847, 1725, 1745, 2053, 2435, 2479, 2836, 2853, 2880, 3131, 3912], 'observations': [340, 1004], 'add': [346], 'further': [347, 844, 859], 'insight': [348], 'into': [349, 539, 673, 1243], 'myocardial': [354, 448, 982, 1142, 1305, 1554, 1907, 2128, 2246, 2289, 2323, 2331, 2555, 2681, 3525], 'cellular': [357], 'cope': [360], 'stress.': [363], 'major': [365, 878, 1692], 'strength': [366], 'work': [369, 436, 1068, 1204, 1234, 1271, 1338], 'comprehensive': [372, 1263], 'evaluation': [373], 'steps': [376], 'cascades,': [380], 'demonstrates': [382], 'clearly': [383], 'are': [387, 425, 507, 514, 521, 558, 581, 1163, 1187, 1201, 1325], 'develop.': [394], 'Although': [395, 897], 'association': [397], 'convincing,': [399], 'it': [400, 573, 1048, 1139, 1284, 1748], 'does': [401], 'prove': [403], 'essential': [408], 'feature': [409], 'pathogenesis.': [412], 'This': [413, 916, 1146], 'will': [414, 1069, 1205, 1272, 1285], 'remain': [415], 'open': [417], 'question': [418], 'until': [419], 'interventions': [420], 'inhibit': [422, 1997], 'specifically': [424], 'shown': [426, 794], 'affect': [428], 'natural': [430, 2283], 'history': [431], 'HF.': [433, 588, 915], 'raises': [437], 'many': [438], 'interesting': [439], 'issues.': [440], 'Download': [441], 'figureDownload': [442], 'PowerPointCentral': [443], 'role': [444, 752, 863, 1224, 1614, 2066, 3132], 'ROS': [446, 493, 586, 743, 799, 1830], 'apoptosis.': [449, 1021, 1281], 'Cellular': [450, 2217, 2570, 3629], 'sources': [451], '·O2−': [453, 461, 710, 845, 955], 'include': [454], 'mitochondria,': [455, 810], 'XO,': [456], 'NAD(P)H': [458], 'oxidase.': [459], 'Elevated': [460], 'production': [462, 732], 'contributes': [466, 1140], 'release': [469, 538, 765, 808, 1512], 'mitochondria': [474, 557, 580, 696, 720, 740, 1046, 1517, 1817], 'activation': [477, 1519, 2932, 3003, 3180], 'participate': [483, 529], 'initiating': [485], 'promoting': [487], 'cascades.': [489], 'Thus,': [490, 1168], 'formation': [491, 711, 797], 'represents': [494, 930], 'central': [496, 748, 862, 1749], 'phenomenon': [497], 'failing': [502, 936, 967, 1792], 'heart.': [503, 969], 'p53': [504], 'p21': [506], 'antiapoptotic': [510, 2674], 'molecules,': [511], 'respectively,': [512], 'p66shc.': [517], 'Bax': [518, 827], 'Bak': [520], 'members': [522, 820], 'BCL-2': [525, 823], 'protein': [526, 629, 1728], 'family': [527, 824], 'membrane': [532, 1018, 1035, 1062], 'pore-opening': [533], 'responsible': [534], 'cytoplasm.': [541], 'Fas': [542], 'cell': [545, 1258, 1648, 1688, 2059, 2068, 2159, 3012, 3223], 'surface': [546], 'receptor': [547, 2235, 3002, 3324, 3331], 'activates': [549], 'cascades': [551], 'when': [552], 'stimulated': [553], 'receptor.Whether': [556], 'initiators': [559], 'secondary': [561], 'victims': [562], 'continues': [565], 'hotly': [568], 'debated.11': [569], 'either': [571], 'case,': [572], 'great': [576], 'mechanistic': [577], 'interest': [578], 'source': [584, 879, 947, 1785], 'Mitochondria': [589], 'generate': [590, 654, 741], 'ATP': [591, 686, 874, 1013, 1993], 'series': [594], 'oxidation-reduction': [596], 'reactions': [597], 'mediated': [598, 3010], 'respiratory': [600, 651, 1835], 'complexes': [601, 652, 662], 'NADH-CoQ': [602], 'reductase': [603, 607, 612], '(complex': [604, 608, 613, 619], 'I),': [605], 'succinate-CoQ': [606], 'II),': [609], 'III),': [614], 'oxidase': [618, 942], 'IV)': [620], 'Cytochrome': [623, 1812], '13-kDa': [627], 'heme-containing': [628], 'serves': [631], 'electron': [634, 637, 837, 1778], 'acceptor': [635], 'facilitating': [636], 'transfer': [638, 646], 'complex': [640, 643, 1056, 1780], 'III': [641], 'IV.': [644], 'electrons': [648], 'allows': [649], 'electrochemical': [656], 'gradient': [657, 679], 'pumping': [659], 'protons': [660], '(through': [661], 'I,': [663, 1670, 2370], 'III,': [664], 'IV;': [666], 'see': [667], 'Figure)': [668], 'matrix': [672], 'inner': [675], 'membrane,': [676], '(proton-motive': [680], 'force)': [681], 'provides': [682], 'energy': [684, 881, 891, 912, 925, 1080, 3551], 'synthesis': [687, 875], 'F0': [689], 'F1': [690], 'ATPase.': [691], 'Superoxide': [692, 2418, 2839], '(·O2−)': [693], 'occurs': [697, 712], 'result': [700, 848], 'incomplete': [702], 'reduction': [703], 'O2': [705, 1053], 'H2O.': [707], 'Whereas': [708], 'some': [709], 'during': [713, 2090, 3776], 'physiological': [714], '(and,': [717], 'compensate,': [719], 'contain': [721], 'superoxide': [722, 1645, 3559], 'dismutase': [723, 1646], 'other': [725], 'antioxidant': [726, 2881], 'defenses),': [727], 'HF,': [729], '·O2': [731], 'greatly': [734], 'augmented.12': [735], 'clear': [737], 'demonstration': [738], 'favors': [746], 'rather': [749], 'than': [750], 'bystander': [751], 'organelles': [755], 'apoptosis.Mitochondria': [757], 'contribute': [758, 842], 'initiate': [761], 'c,': [768], 'stimulates': [772, 3005], 'activating': [774, 2609], 'factor': [775], '(Apaf-1)': [776], 'caspases': [778], '9': [779], '3.': [781], 'Atlante': [782, 1800], 'al,13': [784], 'vitro': [788], 'model': [789], 'neuronal': [791], 'toxicity,': [792], 'may': [800, 841, 893, 909, 1111, 1173, 1192], 'proximate': [803], 'cause': [804], 'process': [813, 1197], 'involves': [815, 3825], 'pore': [817], 'opened': [818], 'proteins,': [826], 'Bak.': [829], 'Loss': [830], 'likely': [834], 'disrupts': [835], 'transport': [838, 1779], 'chain': [839], 'production.': [846], 'more': [850], 'stress,': [852, 2980, 3462, 3531], 'potential': [855, 1036, 1063, 1784], 'vicious': [856], 'cycle': [857], 'apoptosis.The': [861], 'mitochondrion': [866], 'fact': [871], 'cardiac': [883, 975, 1079, 1256, 1588, 1611, 1657, 1687, 2004, 2124, 2163, 2213, 2651, 2884, 3386, 3817], 'myocytes': [884, 1121, 1158, 1464, 1658, 2125], 'suggest': [885], 'disorders': [887], 'linked': [895], 'pathologically.': [896], 'speculative,': [901], 'there': [902], 'also': [910, 1059], 'impair': [911], 'particular': [919], 'significance': [920], 'given': [921, 1151], 'uncoupling': [923], 'performance': [929], 'hallmark': [932], 'lesion': [933], 'heart.14': [937], 'regard,': [940], 'xanthine': [941, 2775], '(XO),': [943], 'newly': [945], 'appreciated': [946], 'generates': [954], 'byproduct': [958], 'purine': [960], 'metabolism,': [961], 'has': [962], 'augmented': [963], 'activity': [964, 2716, 2777, 3465, 3824], 'canine': [968], 'XO': [970], 'inhibition': [971, 3422], 'allopurinol': [973, 990, 1905], 'restores': [974, 3423], 'efficiency': [976, 1913], 'toward': [977], 'normal,15': [978], 'increasing': [981], 'contractility': [983, 3424], 'reducing': [985, 2976], 'consumption.': [987, 2031], 'Additionally,': [988], 'vitamin': [992], 'C': [993, 1965, 3172, 3574], 'potentiate': [994], 'β-adrenergic': [995, 2287, 3323, 3330], 'inotropic': [996, 1968], 'responses': [997], 'animals': [999], 'humans.16,17': [1001], 'Two': [1002], 'support': [1005], 'produce': [1012], '(maintenance': [1014], 'potential)': [1019], 'First,': [1022], 'ATP-sensitive': [1023], 'K+': [1024], 'channel': [1025], 'agonists': [1026, 2380], 'offset': [1027], 'stress–induced': [1030, 1093], 'loss': [1031, 1119, 1179, 1214, 3904], 'apoptosis.18': [1038], 'Second,': [1039], 'nitric': [1040, 2056], 'oxide': [1041, 2057], 'synthase': [1042], 'present': [1044], 'where': [1047, 1185], 'only': [1050], 'physiologically': [1051], 'inhibits': [1052, 1065, 2233], 'consumption': [1054, 1909], 'at': [1055], 'IV': [1057], 'preserves': [1060], 'apoptosis.19,20': [1066], 'Future': [1067, 1203], 'required': [1071], 'explore': [1073], 'interaction': [1075], 'metabolism.Is': [1081], 'totality': [1084], 'sufficient': [1087], 'conclude': [1089], 'final': [1097], 'common': [1098], 'pathway': [1099, 2240, 2563, 3179], 'progressive': [1101, 1123], 'dysfunction?': [1103], 'It': [1104], 'consider': [1108, 1289], 'whole': [1115], 'story': [1116], 'behind': [1117], 'net': [1118], 'dysfunction.': [1125], 'As': [1126], 'basic': [1130], 'mechanism': [1131, 2022, 2671, 3499], 'embryogenesis': [1134], 'tissue': [1136], 'repair,21': [1137], 'perhaps': [1138], 'restoration': [1143], 'after': [1144, 1553, 2127], 'injury.': [1145], 'possibility': [1147], 'especially': [1149], 'relevant': [1150], 'reports': [1152], 'same': [1155], 'group': [1156], 'undergo': [1160], 'mitosis': [1161], 'therefore': [1164], 'terminally': [1166], 'differentiated.22,23': [1167], 'reflect': [1174], 'imbalance': [1176], 'replacement.': [1181], 'setting': [1184], 'cells': [1186, 1200, 2027, 3142], 'being': [1188], 'appropriately': [1189], 'replaced,': [1190], 'actually': [1193], 'represent': [1194], 'favorable': [1196], 'whereby': [1198], 'damaged': [1199], 'removed.': [1202], 'need': [1206, 1273], 'examine': [1208], 'relative': [1210], 'rates': [1211], 'regeneration': [1216], 'models,': [1219], 'well': [1221], 'plays': [1227], 'stimulating': [1229], 'inhibiting': [1231, 2558, 3529], 'mitosis.The': [1233], 'introduces': [1239], 'increasingly': [1245], 'complicated': [1246], 'array': [1247], 'biochemical': [1249], 'events': [1250], 'link': [1252], 'programmed': [1257, 2157], 'death.': [1259, 1842, 2071], 'To': [1260], 'obtain': [1261], 'view': [1264], 'how': [1266], 'progresses,': [1269], 'future': [1270], 'separate': [1275], 'adaptive': [1276], 'nonadaptive': [1278], 'consequences': [1279], 'broader': [1291], 'spectrum': [1292], 'roles': [1294], 'played': [1295], 'depression': [1303], 'energetics.': [1306], 'Understanding': [1307], 'potentially': [1309], 'reversible': [1310], 'processes': [1311], 'offers': [1312], 'hope': [1313], 'novel': [1315, 3327], 'treatment': [1316], 'strategies': [1317], 'HF.The': [1319], 'opinions': [1320], 'expressed': [1321], 'editorial': [1324], 'necessarily': [1327], 'those': [1328], 'editors': [1331], 'American': [1335, 3115, 3333, 3435, 3589], 'Association.This': [1337], 'was': [1339], 'supported': [1340], 'NIH': [1342], 'grant': [1343], 'RO1': [1344], 'HL-65455': [1345], 'Paul': [1348], 'Beeson': [1349], 'Physician': [1350], 'Faculty': [1351], 'Scholars': [1352], 'Aging': [1354], 'Research': [1355, 3302], 'Award.FootnotesCorrespondence': [1356], 'Hare,': [1360], 'MD,': [1361], 'Hospital,': [1364], '600': [1368], 'N': [1369, 1434, 1469, 2130, 2201, 3129], 'Wolfe': [1370], 'St,': [1371], 'Carnegie': [1372], '568,': [1373], 'MD': [1375], '21287-6568.': [1376], 'E-mail': [1377], '[email': [1378], 'protected]': [1379], 'References': [1380], '1': [1381, 2892], 'Adams': [1382], 'KFJ.': [1383], 'New': [1384, 3790], 'epidemiologic': [1385], 'perspectives': [1386], 'concerning': [1387], 'mild-to-moderate': [1388], 'failure.': [1390, 1433, 1468, 1879, 1919, 1954], 'Am': [1391, 1558], 'J': [1392, 1436, 1471, 1559, 1843, 2132, 2375, 2708, 3251, 3418, 3457, 3806], 'Med.': [1393, 1437, 1472, 2133], '2001;': [1394, 1438, 1564, 1591, 1705, 1753, 1956, 1980, 2008, 2134], '110': [1395], '(suppl': [1396], '7A):': [1397], '6S–13S.Google': [1398], 'Scholar2': [1399], 'Packer': [1400], 'M,': [1401, 1415, 1501, 1543, 1712, 1985, 2261, 2312, 2354, 2509, 2541, 2586, 2631, 2696, 2702, 2747, 2823, 2991, 3124, 3158, 3360], 'Coats': [1402], 'AJ,': [1403], 'Fowler': [1404], 'MB,': [1405], 'Katus': [1406], 'HA,': [1407], 'Krum': [1408], 'H,': [1409, 1760, 1764, 1897, 1931, 2409, 2580, 2761, 2807, 2819, 2963, 3066, 3080, 3090, 3352, 3364, 3710, 3843], 'Mohacsi': [1410], 'P,': [1411, 1480, 1718, 1803, 2186, 2364], 'Rouleau': [1412], 'JL,': [1413], 'Tendera': [1414], 'Castaigne': [1416], 'A,': [1417, 1495, 1537, 1539, 1682, 1801, 1805, 1807, 1933, 1987, 2046, 2116, 2188, 2194, 2270, 2344, 2348, 2366, 2443, 2698, 3070, 3407, 3452, 3647, 3713], 'Roecker': [1418], 'EB,': [1419], 'Schultz': [1420], 'MK,': [1421], 'DeMets': [1422], 'DL.': [1423], 'Effect': [1424, 3856, 3935], 'carvedilol': [1426], 'on': [1427, 1610, 2058, 2643, 2672, 2843, 3618, 3860], 'survival': [1428, 2069], 'severe': [1430], 'chronic': [1431, 1584, 2382, 2485, 2725, 2786, 3391], 'Engl': [1435, 1470, 2131], '344:': [1439, 2135], '1651–1658.CrossrefMedlineGoogle': [1440], 'Scholar3': [1441], 'Narula': [1442, 1477, 1485], 'J,': [1443, 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[2513, 2667, 3544], 'Dieterlen': [2515], 'M': [2516, 3651, 3890, 3924], 'Cardiomyopathy': [2519, 3664], 'Affects': [2520], 'Thioredoxin': [2522], 'System': [2523], 'Myocardium,': [2527], 'Cardiac': [2530, 3683, 3692], 'Failure,': [2531, 2732], '10.1016/j.cardfail.2019.01.017,': [2532], '25:3,': [2533], '(204-212),': [2534], '1-Mar-2019.': [2538, 2578], 'Nagoor': [2539], '(2018)': [2551, 2639, 2668], 'α-Bisabolol': [2552], 'abrogates': [2553], 'intrinsic': [2562], '10.1007/s11010-018-3434-5,': [2572], '453:1-2,': [2573], '(89-102),': [2574], 'Park': [2579, 2600], 'Shin': [2581], 'Yoou': [2583], 'Kim': [2587, 2595], 'Sung': [2589], 'Yu': [2591, 2956], 'Lee': [2593], 'Bae': [2597], 'Hydrogen': [2603], 'peroxide': [2604], 'constricts': [2605], 'arteries': [2607], 'Na': [2610], '+': [2611], '-permeable': [2612, 2616], 'Ca': [2614], '2+': [2615], 'cation': [2617], ',': [2619, 3911], '10.1080/10715762.2018.1556394,': [2623], '53:1,': [2624], '(94-103),': [2625], '2-Jan-2019.': [2629], 'Kara': [2630], 'Ozcagli': [2632], 'Kotil': [2634], 'T': [2635, 2767, 3372], 'Alpertunga': [2637], 'B': [2638, 3126], 'Effects': [2640], 'stanozolol': [2642], 'tissue,': [2652], 'Steroids,': [2653], '10.1016/j.steroids.2018.02.004,': [2654], '134,': [2655], '(96-100),': [2656], '1-Jun-2018.': [2660], 'Stanely': [2661, 3511], 'Mainzen': [2662, 3512], 'Prince': [2663, 3513], 'P': [2664, 2996, 3514, 3729], 'Hemalatha': [2666], 'molecular': [2670], 'zingerone': [2677], 'isoproterenol': [2679], 'infarcted': [2682, 3526, 3625], 'European': [2684, 2728], 'Pharmacology,': [2687, 2906, 3503], '10.1016/j.ejphar.2017.09.051,': [2688], '821,': [2689], '(105-111),': [2690], '1-Feb-2018.': [2694], 'Hammadah': [2695], 'Kalogeropoulos': [2697], 'Georgiopoulou': [2699], 'Weber': [2701], 'Wu': [2703, 2914, 2958], 'Hazen': [2705], 'Butler': [2707], 'Tang': [2710], 'W': [2711, 3248, 3571], '(2017)': [2712, 2771], 'High-density': [2713], 'lipoprotein-associated': [2714], 'paraoxonase-1': [2715], 'prediction': [2718], 'adverse': [2720], 'outcomes': [2721], 'outpatients': [2723], 'failure,': [2727, 2788, 3393, 3471], '10.1002/ejhf.777,': [2733], '19:6,': [2734], '(748-755),': [2735], '1-Jun-2017.': [2739], 'Otaki': [2740, 2800, 3063, 3347], 'Watanabe': [2742, 2802, 3067, 3349], 'Kinoshita': [2744], 'Yokoyama': [2746], 'Takahashi': [2748, 2760, 2806, 3065, 3351], 'Toshima': [2750], 'Sugai': [2752], 'Murase': [2754], 'Nakamura': [2756], 'Nishiyama': [2758, 2804, 3365], 'Arimoto': [2762, 2808, 3083, 3367], 'Shishido': [2764, 2810, 3085, 3369], 'Miyamoto': [2766, 2812, 3087, 3371], 'Kubota': [2769, 2830, 3094, 3374], 'Association': [2772, 3377], 'plasma': [2774, 3379], 'oxidoreductase': [2776], 'severity': [2779], 'clinical': [2781, 3785], 'outcome': [2782], 'International': [2789, 3229, 3532], '10.1016/j.ijcard.2016.11.077,': [2793], '228,': [2794], '(151-157),': [2795], '1-Feb-2017.': [2799], 'Konta': [2814], 'Shibata': [2816], 'Sato': [2818], 'Kawasaki': [2820], 'Daimon': [2822], 'Ueno': [2824], 'Kato': [2826], 'Kayama': [2828], 'Fukumoto': [2833], '(2016)': [2835, 2879, 2929, 2969, 2997, 3042, 3096, 3130], 'Impact': [2837], 'Dismutase-1': [2840], 'Genetic': [2841], 'Variation': [2842], 'Cardiovascular': [2844, 3054, 3291, 3738, 3951], 'All-Cause': [2846], 'Mortality': [2847], 'Prospective': [2850], 'Cohort': [2851], 'Study:': [2852], 'Yamagata': [2854], '(Takahata)': [2855], 'Study,': [2856], 'PLOS': [2857], 'ONE,': [2858], '10.1371/journal.pone.0164732,': [2859], '11:10,': [2860], '(e0164732)': [2861], 'Ji': [2862], 'Gong': [2870], 'Wei': [2872], 'Li': [2874, 3040], 'X': [2875], 'Qin': [2877], 'L': [2878, 3483], 'edaravone': [2882], 'prevents': [2883, 2940, 3218, 3322], 'suppressing': [2887], 'type': [2891, 3318], 'diabetic': [2893], 'rats': [2894, 3527], 'high-glucose-induced': [2897], 'injured': [2898], 'cardiomyoblasts,': [2900], 'Canadian': [2901], 'Physiology': [2904], '10.1139/cjpp-2015-0587,': [2907], '94:9,': [2908], '(996-1006),': [2909], '1-Sep-2016.': [2913], 'Guo': [2916], 'Lin': [2918, 3161], 'Kan': [2922], 'Chen': [2924, 3157, 3171, 3174, 3604], 'Zhu': [2927], 'Gp130-mediated': [2930], 'STAT3': [2931], 'S-propargyl-cysteine,': [2934], 'endogenous': [2936], 'hydrogen': [2937], 'sulfide': [2938], 'initiator,': [2939], 'doxorubicin-induced': [2941, 3219, 3493], 'cardiotoxicity,': [2942], 'Cell': [2943, 3661], 'Death': [2944], 'Disease,': [2946, 3739], '10.1038/cddis.2016.209,': [2947], '7:8,': [2948], '(e2339-e2339),': [2949], '1-Aug-2016.': [2953], 'Qi': [2960], 'Z': [2965, 2968, 3276], 'Scutellarin': [2970], 'protects': [2971], 'cardiomyocyte': [2972, 3467], 'ischemia–reperfusion': [2973], 'Life': [2981], '10.1016/j.lfs.2016.01.018,': [2983], '157,': [2984], '(200-207),': [2985], '1-Jul-2016.': [2989], 'Jagadeesh': [2992], 'Selvaraj': [2995], 'Synthetic': [2998], 'catecholamine': [2999], 'triggers': [3000], 'β1-adrenergic': [3001], 'cardiotoxicity': [3006], 'via': [3007, 3903], 'rats:': [3015, 3497], 'Abrogating': [3016], 'action': [3017], 'thymol,': [3019], 'Chemico-Biological': [3020], 'Interactions,': [3021], '10.1016/j.cbi.2016.03.017,': [3022], '251,': [3023], '(17-25),': [3024], '1-May-2016.': [3028], 'Ye': [3029], 'Hou': [3031], 'Xiao': [3033, 3840, 3846], 'H': [3038, 3175, 3212, 3215, 3547], 'F': [3041], 'Dynamic': [3043], 'monitoring': [3044], 'double-strand': [3048], 'break': [3049], 'repair': [3051, 3137, 3900, 3908], 'cardiomyocytes,': [3053], 'Pathology,': [3055, 3197], '10.1016/j.carpath.2015.10.010,': [3056], '25:2,': [3057], '(93-100),': [3058], '1-Mar-2016.': [3062], 'Funayama': [3069], 'Netsu': [3071], 'Honda': [3073, 3081, 3357], 'Narumi': [3075, 3355], 'Kadowaki': [3077, 3353], 'Hasegawa': [3079], 'Kamata': [3089], 'Nakajima': [3091], 'O': [3092], 'HECT‐Type': [3097], 'Ubiquitin': [3098], 'E3': [3099], 'Ligase': [3100], 'ITCH': [3101], 'Interacts': [3102], 'Thioredoxin‐Interacting': [3104], 'Protein': [3105], 'Ameliorates': [3107], 'Reactive': [3108], 'Oxygen': [3109], 'Species–Induced': [3110], 'Cardiotoxicity,': [3111], 'Association,': [3117], '5:1,': [3118], '13-Jan-2016.': [3122], 'Vasko': [3123], 'Shariati': [3125], 'Zanville': [3128], 'toxicity': [3139], 'postmitotic': [3141], 'caused': [3143], 'cancer': [3145], 'therapies': [3146], 'Repair': [3148, 3684], 'Cancer': [3150, 3668], 'Therapy,': [3151], '10.1016/B978-0-12-803582-5.00013-9,': [3152], '(383-428),': [3153], '.': [3154, 3307, 3696, 3708], 'Huang': [3163, 3642], 'Pan': [3165], 'Ho': [3167], 'Fang': [3169], '(2015)': [3176, 3280], 'atria': [3183], 'due': [3188], 'mitral': [3190], 'tricuspid': [3192], 'regurgitation,': [3193], '10.1016/j.yexmp.2015.05.007,': [3198], '99:1,': [3199], '(65-73),': [3200], '1-Aug-2015.': [3204], 'LI': [3205], 'KIM': [3207, 3211], 'YADAV': [3209], 'CHAE': [3214], '(2015)(2015)': [3216], 'Sulforaphane': [3217], '10.3892/ijmm.2015.2199,': [3234], '36:1,': [3235], '(53-64),': [3236], '1-Jul-2015.': [3240], 'Mayo': [3243, 3410], 'Rangel': [3245], '(2014)': [3252, 3315, 3376, 3419], 'Interaction': [3253], 'Between': [3254], 'Neuronal': [3255], 'Nitric': [3256], 'Oxide': [3257], 'Synthase': [3258], 'Signaling': [3259], 'Temperature': [3261], 'Influences': [3262], 'Sarcoplasmic': [3263], 'Reticulum': [3264], 'Calcium': [3265], 'Leak,': [3266], '116:1,': [3269], '(46-55),': [3270], '2-Jan-2015.': [3274], 'Maghbooli': [3275], 'Hossein-nezhad': [3278], 'Transcriptome': [3281], 'Endocrinology': [3284], 'Aspects': [3285], 'Epicardial': [3287], 'Adipose': [3288], 'Tissue': [3289], 'Diseases:': [3292], 'Systematic': [3294], 'Review': [3295], 'Meta-Analysis': [3297], 'Observational': [3299], 'Studies,': [3300], 'BioMed': [3301], 'International,': [3303], '10.1155/2015/926567,': [3304], '2015,': [3305], '(1-12),': [3306], 'Vatner': [3310, 3313], 'D': [3314], 'Disruption': [3316], '5': [3319], 'adenylyl': [3320], 'cyclase': [3321], 'cardiomyopathy:': [3325], 'approach': [3328], 'blockade,': [3332], 'Physiology-Heart': [3336, 3438], 'Circulatory': [3338, 3440], 'Physiology,': [3339, 3441, 3830], '10.1152/ajpheart.00491.2014,': [3340], '307:10,': [3341], '(H1521-H1528),': [3342], '15-Nov-2014.': [3346], 'Wanezaki': [3359], 'Sasaki': [3361], 'Tamura': [3363], 'thioredoxin-1': [3380], 'renal': [3382], 'tubular': [3383], 'prognosis': [3387], '10.1016/j.jjcc.2014.02.016,': [3397], '64:5,': [3398], '(353-359),': [3399], '1-Nov-2014.': [3403], 'Gonzalez': [3404], 'Treuer': [3406], 'Lamirault': [3408], 'Cao': [3412], 'R': [3415, 3654, 3698, 3893], 'NADPH': [3420], 'oxidase-2': [3421], 'intracellular': [3426], 'calcium': [3427], 'handling': [3428], 'reduces': [3430, 3460], 'arrhythmogenicity': [3431], 'dystrophic': [3433], 'cardiomyopathy,': [3434, 3867], '10.1152/ajpheart.00890.2013,': [3442], '307:5,': [3443], '(H710-H721),': [3444], '1-Sep-2014.': [3448], 'WU': [3449], 'LUO': [3451], 'ZHOU': [3453], 'REN': [3456], '(2014)(2014)': [3458], 'N-acetylcysteine': [3459], 'factor-κB': [3464], 'Medicine': [3473], 'Reports,': [3474, 3742], '10.3892/mmr.2014.2292,': [3475], '10:2,': [3476], '(615-624),': [3477], '1-Aug-2014.': [3481], 'Ahmed': [3482], 'EL-Maraghy': [3485], '(2013)': [3487, 3518, 3548, 3575, 3613, 3655, 3679, 3699], 'Nicorandil': [3488], 'ameliorates': [3489], 'Possible': [3498], 'cardioprotection,': [3501], '10.1016/j.bcp.2013.07.005,': [3504], '86:9,': [3505], '(1301-1310),': [3506], '1-Nov-2013.': [3510], 'Roy': [3516], 'p-Coumaric': [3519], 'acid': [3520], '10.1016/j.ijcard.2013.04.138,': [3536], '168:4,': [3537], '(3259-3266),': [3538], '1-Oct-2013.': [3542], 'Das': [3543], 'Muniyappa': [3546], 'Age-dependent': [3549], 'dynamics': [3552], 'mice': [3555], 'heart:': [3556], 'Role': [3557], 'dismutase-2,': [3560], 'Gerontology,': [3562], '10.1016/j.exger.2013.06.002,': [3563], '48:9,': [3564], '(947-959),': [3565], '1-Sep-2013.': [3569], 'Paulus': [3570], 'Tschöpe': [3573], 'Novel': [3577], 'Paradigm': [3578], 'Preserved': [3583], 'Ejection': [3584], 'Fraction,': [3585], 'College': [3590], '10.1016/j.jacc.2013.02.092,': [3593], '62:4,': [3594], '(263-271),': [3595], '1-Jul-2013.': [3599, 3637], 'Zhao': [3600, 3602], 'Qu': [3606], 'Gerling': [3608], 'Sun': [3611, 3677], 'Modification': [3614], 'gene': [3619], 'expression': [3620], 'profiling': [3621], 'heart,': [3626], '10.1007/s11010-013-1646-2,': [3631], '379:1-2,': [3632], '(243-253),': [3633], 'Maity': [3640], 'Gao': [3644], 'Stewart': [3646], 'Weiss': [3648], 'Anderson': [3650], 'G-protein': [3656], 'Inactivator': [3657], 'RGS6': [3658], 'Mediates': [3659], 'Myocardial': [3660, 3700, 3735, 3948], 'Caused': [3665], 'Doxorubicin,': [3667], '10.1158/0008-5472.CAN-12-3453,': [3670], '73:6,': [3671], '(1662-1667),': [3672], '15-Mar-2013.': [3676], 'Remodeling:': [3686], 'Pathways': [3688], 'Therapeutic': [3690], 'Strategies': [3691], 'Remodeling,': [3693, 3736], '10.1007/978-1-4614-5930-9_23,': [3694], '(413-425),': [3695], 'Tomanek': [3697], 'Ischemia': [3701], 'Infarction': [3703], 'Coronary': [3704], 'Vasculature,': [3705], '10.1007/978-1-4614-4887-7_10,': [3706], '(189-220),': [3707], 'Verdejo': [3709], 'del': [3711], 'Campo': [3712], 'Troncoso': [3714], 'Gutierrez': [3716], 'Toro': [3718], 'Quiroga': [3720], 'Pedrozo': [3722], 'Munoz': [3724], 'Garcia': [3726], 'Castro': [3728], 'Lavandero': [3731], '(2012)': [3733, 3767, 3810, 3855, 3894], 'Mitochondria,': [3734], 'Current': [3740], 'Hypertension': [3741], '10.1007/s11906-012-0305-4,': [3743], '14:6,': [3744], '(532-539),': [3745], '1-Dec-2012.': [3749], 'Stromberg': [3750], 'Raymond': [3752], 'Samuel': [3754], 'Crockford': [3756], 'Stigall': [3758], 'Leonard': [3760], 'Mendeloff': [3762], 'Gormley': [3765], 'Use': [3768], 'cardioprotectants': [3771], 'thymosin': [3772], 'β4': [3773], 'dexrazoxane': [3775], 'congenital': [3777], 'surgery:': [3779], 'proposal': [3780], 'randomized,': [3783], 'double-blind,': [3784], 'trial,': [3786], 'Annals': [3787], 'York': [3791], '10.1111/j.1749-6632.2012.06710.x,': [3795], '1270:1,': [3796], '(59-65),': [3797], '1-Oct-2012.': [3801], 'Velez': [3802], 'Rueda': [3803], 'Palomeque': [3805], 'Mattiazzi': [3808], 'Early': [3811], 'different': [3814], 'models': [3815], 'hypertrophy': [3818], 'high': [3821], 'renin-angiotensin': [3822], 'system': [3823], 'CaMKII,': [3826], 'Applied': [3829], '10.1152/japplphysiol.01383.2011,': [3831], '112:12,': [3832], '(2110-2120),': [3833], '15-Jun-2012.': [3837], 'He': [3838], 'Fu': [3842], 'Du': [3844], 'Gu': [3850], 'Ma': [3853], 'arrhythmia': [3862], 'rabbits': [3864], 'adriamycin-induced': [3866], 'Huazhong': [3870], 'University': [3871], 'Science': [3873], 'Technology': [3875], '[Medical': [3876], 'Sciences],': [3877], '10.1007/s11596-012-0058-y,': [3878], '32:3,': [3879], '(334-339),': [3880], '1-Jun-2012.': [3884], 'Siggens': [3885], 'Figg': [3887], 'Bennett': [3889], 'Foo': [3892], 'Nutrient': [3895], 'deprivation': [3896], 'regulates': [3897], 'cardiomyocytes': [3902], 'base‐excision': [3907], 'enzyme': [3909], 'OGG1': [3910], 'FASEB': [3913], 'Journal,': [3914], '10.1096/fj.11-197525,': [3915], '26:5,': [3916], '(2117-2124),': [3917], '1-May-2012.': [3921], 'Mari': [3922], 'Kannan': [3923], 'Darlin': [3926], 'Quine': [3927], '(2011)': [3929], 'Mechanistic': [3930], 'Clues': [3931], 'Protective': [3934], 'Ellagic': [3937], 'Acid': [3938], 'Against': [3939], 'Decreased': [3942], 'Respiratory': [3944], 'Enzyme': [3945], 'Activities': [3946], 'Infarcted': [3949], 'Rats,': [3950], '10.1007/s12012-011-9138-7,': [3953], '12:1,': [3954], '(56-63),': [3955], '1-Mar': [3959]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2162316241', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 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