The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

Name: Work Video:
Duration: 3 min 30 s
Chao Peng; Zhike Lu; Zhongyu Xie; Zhongyi Cheng; Yue Chen; Minjia Tan; Hao Luo; Yi Zhang; Wendy He; Ke Yang; Bernadette Zwaans; Daniel X. Tishkoff; Linh Ho; David B. Lombard; Tong‐Chuan He; Junbiao Dai; Eric Verdin; Yang Ye; Yingming Zhao
{'id': 'https://openalex.org/W2162002416', 'doi': 'https://doi.org/10.1074/mcp.m111.012658', 'title': 'The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme', 'display_name': 'The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme', 'publication_year': 2011, 'publication_date': '2011-09-10', 'ids': {'openalex': 'https://openalex.org/W2162002416', 'doi': 'https://doi.org/10.1074/mcp.m111.012658', 'mag': '2162002416', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21908771', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3237090'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m111.012658', 'pdf_url': 'http://www.mcponline.org/article/S1535947620305879/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.mcponline.org/article/S1535947620305879/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5045809285', 'display_name': 'Chao Peng', 'orcid': 'https://orcid.org/0000-0002-6814-2676'}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chao Peng', 'raw_affiliation_strings': ['Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637'], 'affiliations': [{'raw_affiliation_string': 'Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637', 'institution_ids': ['https://openalex.org/I40347166']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108194597', 'display_name': 'Zhike Lu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhike Lu', 'raw_affiliation_strings': ['Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637'], 'affiliations': [{'raw_affiliation_string': 'Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637', 'institution_ids': ['https://openalex.org/I40347166']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077042154', 'display_name': 'Zhongyu Xie', 'orcid': 'https://orcid.org/0000-0001-5394-8282'}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhongyu Xie', 'raw_affiliation_strings': ['Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637'], 'affiliations': [{'raw_affiliation_string': 'Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637', 'institution_ids': ['https://openalex.org/I40347166']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038766662', 'display_name': 'Zhongyi Cheng', 'orcid': 'https://orcid.org/0000-0002-8764-2019'}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhongyi Cheng', 'raw_affiliation_strings': ['Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637'], 'affiliations': [{'raw_affiliation_string': 'Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637', 'institution_ids': ['https://openalex.org/I40347166']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100454838', 'display_name': 'Yue Chen', 'orcid': 'https://orcid.org/0000-0003-4088-7649'}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yue Chen', 'raw_affiliation_strings': ['Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637'], 'affiliations': [{'raw_affiliation_string': 'Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637', 'institution_ids': ['https://openalex.org/I40347166']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086770255', 'display_name': 'Minjia Tan', 'orcid': 'https://orcid.org/0000-0002-6784-9653'}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Minjia Tan', 'raw_affiliation_strings': ['Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637'], 'affiliations': [{'raw_affiliation_string': 'Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637', 'institution_ids': ['https://openalex.org/I40347166']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009471000', 'display_name': 'Hao Luo', 'orcid': 'https://orcid.org/0000-0003-2714-8817'}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hao Luo', 'raw_affiliation_strings': ['Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637'], 'affiliations': [{'raw_affiliation_string': 'Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637', 'institution_ids': ['https://openalex.org/I40347166']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100388133', 'display_name': 'Yi Zhang', 'orcid': 'https://orcid.org/0000-0002-2657-4876'}, 'institutions': [{'id': 'https://openalex.org/I4210112820', 'display_name': 'Shanghai Institute of Materia Medica', 'ror': 'https://ror.org/022syn853', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210112820']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yi Zhang', 'raw_affiliation_strings': ['Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P.R. China', 'institution_ids': ['https://openalex.org/I4210112820', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008288206', 'display_name': 'Wendy He', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1321430492', 'display_name': 'Gladstone Institutes', 'ror': 'https://ror.org/038321296', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1321430492']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wendy He', 'raw_affiliation_strings': ['Gladstone Institute of Virology and Immunology, San Francisco, CA 94158'], 'affiliations': [{'raw_affiliation_string': 'Gladstone Institute of Virology and Immunology, San Francisco, CA 94158', 'institution_ids': ['https://openalex.org/I1321430492']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073591830', 'display_name': 'Ke Yang', 'orcid': 'https://orcid.org/0000-0003-0022-0620'}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ke Yang', 'raw_affiliation_strings': ['Molecular Oncology Laboratory, Department of Surgery, The University of Chicago, Chicago, IL 60637'], 'affiliations': [{'raw_affiliation_string': 'Molecular Oncology Laboratory, Department of Surgery, The University of Chicago, Chicago, IL 60637', 'institution_ids': ['https://openalex.org/I40347166', 'https://openalex.org/I4210150208']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052870430', 'display_name': 'Bernadette Zwaans', 'orcid': 'https://orcid.org/0000-0002-4717-5751'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bernadette M.M. Zwaans', 'raw_affiliation_strings': ['Department of Pathology and Institute of Gerontology, Ann Arbor, MI 48109'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Institute of Gerontology, Ann Arbor, MI 48109', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064668487', 'display_name': 'Daniel X. Tishkoff', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel Tishkoff', 'raw_affiliation_strings': ['Department of Pathology and Institute of Gerontology, Ann Arbor, MI 48109'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Institute of Gerontology, Ann Arbor, MI 48109', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088634252', 'display_name': 'Linh Ho', 'orcid': 'https://orcid.org/0000-0001-9252-8539'}, 'institutions': [{'id': 'https://openalex.org/I1321430492', 'display_name': 'Gladstone Institutes', 'ror': 'https://ror.org/038321296', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1321430492']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Linh Ho', 'raw_affiliation_strings': ['Gladstone Institute of Virology and Immunology, San Francisco, CA 94158'], 'affiliations': [{'raw_affiliation_string': 'Gladstone Institute of Virology and Immunology, San Francisco, CA 94158', 'institution_ids': ['https://openalex.org/I1321430492']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082825241', 'display_name': 'David B. Lombard', 'orcid': 'https://orcid.org/0000-0002-4292-0185'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David Lombard', 'raw_affiliation_strings': ['Department of Pathology and Institute of Gerontology, Ann Arbor, MI 48109'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Institute of Gerontology, Ann Arbor, MI 48109', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070578608', 'display_name': 'Tong‐Chuan He', 'orcid': 'https://orcid.org/0000-0001-7721-3934'}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tong-Chuan He', 'raw_affiliation_strings': ['Molecular Oncology Laboratory, Department of Surgery, The University of Chicago, Chicago, IL 60637'], 'affiliations': [{'raw_affiliation_string': 'Molecular Oncology Laboratory, Department of Surgery, The University of Chicago, Chicago, IL 60637', 'institution_ids': ['https://openalex.org/I40347166', 'https://openalex.org/I4210150208']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072203343', 'display_name': 'Junbiao Dai', 'orcid': 'https://orcid.org/0000-0002-5299-4700'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Junbiao Dai', 'raw_affiliation_strings': ['School of Life Sciences, Tsinghua University, Beijing 100084, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Sciences, Tsinghua University, Beijing 100084, P. R. China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025168089', 'display_name': 'Eric Verdin', 'orcid': 'https://orcid.org/0000-0003-3703-3183'}, 'institutions': [{'id': 'https://openalex.org/I1321430492', 'display_name': 'Gladstone Institutes', 'ror': 'https://ror.org/038321296', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1321430492']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eric Verdin', 'raw_affiliation_strings': ['Gladstone Institute of Virology and Immunology, San Francisco, CA 94158'], 'affiliations': [{'raw_affiliation_string': 'Gladstone Institute of Virology and Immunology, San Francisco, CA 94158', 'institution_ids': ['https://openalex.org/I1321430492']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100402381', 'display_name': 'Yang Ye', 'orcid': 'https://orcid.org/0000-0003-1316-5915'}, 'institutions': [{'id': 'https://openalex.org/I4210112820', 'display_name': 'Shanghai Institute of Materia Medica', 'ror': 'https://ror.org/022syn853', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210112820']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yang Ye', 'raw_affiliation_strings': ['Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, P.R. China', 'institution_ids': ['https://openalex.org/I4210112820', 'https://openalex.org/I19820366']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5021547370', 'display_name': 'Yingming Zhao', 'orcid': 'https://orcid.org/0000-0003-1928-2151'}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Yingming Zhao', 'raw_affiliation_strings': ['Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637'], 'affiliations': [{'raw_affiliation_string': 'Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637', 'institution_ids': ['https://openalex.org/I40347166']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5021547370'], 'corresponding_institution_ids': ['https://openalex.org/I40347166'], 'apc_list': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'apc_paid': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'fwci': 23.28, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 673, 'citation_normalized_percentile': {'value': 0.999452, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '10', 'issue': '12', 'first_page': 'M111.012658', 'last_page': 'M111.012658'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11051', 'display_name': 'Sirtuins and Resveratrol in Medicine', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11051', 'display_name': 'Sirtuins and Resveratrol in Medicine', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12620', 'display_name': 'Signaling Pathways in Disease', 'score': 0.988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/succinylation', 'display_name': 'Succinylation', 'score': 0.8769151}], 'concepts': [{'id': 'https://openalex.org/C2776016237', 'wikidata': 'https://www.wikidata.org/wiki/Q178430', 'display_name': 'Lysine', 'level': 3, 'score': 0.9341897}, {'id': 'https://openalex.org/C12290205', 'wikidata': 'https://www.wikidata.org/wiki/Q22284030', 'display_name': 'Succinylation', 'level': 4, 'score': 0.8769151}, {'id': 'https://openalex.org/C119157956', 'wikidata': 'https://www.wikidata.org/wiki/Q796604', 'display_name': 'Acetylation', 'level': 3, 'score': 0.81092274}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.6691592}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.52162987}, {'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.5108804}, {'id': 'https://openalex.org/C31827203', 'wikidata': 'https://www.wikidata.org/wiki/Q874296', 'display_name': 'Tandem mass spectrometry', 'level': 3, 'score': 0.4567588}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.44738227}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42317936}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.2224437}, {'id': 'https://openalex.org/C162356407', 'wikidata': 'https://www.wikidata.org/wiki/Q180809', 'display_name': 'Mass spectrometry', 'level': 2, 'score': 0.17174247}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.11969301}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.061808765}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008239', 'descriptor_name': 'Lysine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008314', 'descriptor_name': 'Malonates', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D037761', 'descriptor_name': 'Sirtuins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000918', 'descriptor_name': 'Antibody Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002851', 'descriptor_name': 'Chromatography, High Pressure Liquid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D029968', 'descriptor_name': 'Escherichia coli Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029968', 'descriptor_name': 'Escherichia coli Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D029968', 'descriptor_name': 'Escherichia coli Proteins', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D029968', 'descriptor_name': 'Escherichia coli Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008239', 'descriptor_name': 'Lysine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008314', 'descriptor_name': 'Malonates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009842', 'descriptor_name': 'Oligopeptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009842', 'descriptor_name': 'Oligopeptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009842', 'descriptor_name': 'Oligopeptides', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010446', 'descriptor_name': 'Peptide Fragments', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010735', 'descriptor_name': 'Phosphoglycerate Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010735', 'descriptor_name': 'Phosphoglycerate Kinase', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010735', 'descriptor_name': 'Phosphoglycerate Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010751', 'descriptor_name': 'Phosphopyruvate Hydratase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010751', 'descriptor_name': 'Phosphopyruvate Hydratase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010751', 'descriptor_name': 'Phosphopyruvate Hydratase', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D037761', 'descriptor_name': 'Sirtuins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D037761', 'descriptor_name': 'Sirtuins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013386', 'descriptor_name': 'Succinates', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013386', 'descriptor_name': 'Succinates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053719', 'descriptor_name': 'Tandem Mass Spectrometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m111.012658', 'pdf_url': 'http://www.mcponline.org/article/S1535947620305879/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3237090', 'pdf_url': 'https://europepmc.org/articles/pmc3237090?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237090', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21908771', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m111.012658', 'pdf_url': 'http://www.mcponline.org/article/S1535947620305879/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W1548938601', 'https://openalex.org/W163303422', 'https://openalex.org/W1969899640', 'https://openalex.org/W1975306346', 'https://openalex.org/W1978842703', 'https://openalex.org/W1981549228', 'https://openalex.org/W1981593008', 'https://openalex.org/W1985180051', 'https://openalex.org/W1989899886', 'https://openalex.org/W2002609852', 'https://openalex.org/W2004362700', 'https://openalex.org/W2028161249', 'https://openalex.org/W2029130907', 'https://openalex.org/W2032983681', 'https://openalex.org/W2059750004', 'https://openalex.org/W2065034018', 'https://openalex.org/W2075045273', 'https://openalex.org/W2092000214', 'https://openalex.org/W2093509030', 'https://openalex.org/W2097326711', 'https://openalex.org/W2101298061', 'https://openalex.org/W2101431784', 'https://openalex.org/W2117473844', 'https://openalex.org/W2147207778'], 'related_works': ['https://openalex.org/W4380480703', 'https://openalex.org/W4200264640', 'https://openalex.org/W3156776868', 'https://openalex.org/W2884980362', 'https://openalex.org/W2796877990', 'https://openalex.org/W2724145149', 'https://openalex.org/W2605917783', 'https://openalex.org/W2582240129', 'https://openalex.org/W2409007332', 'https://openalex.org/W1969899640'], 'abstract_inverted_index': {'Protein': [0, 171, 429, 484, 555, 634, 667, 2012], 'post-translational': [1, 172, 408, 467, 474, 485, 534, 811, 2380, 3121, 3635, 3977], 'modifications': [2, 173, 409, 468, 535, 710], '(PTMs)': [3, 174, 469], 'at': [4, 175, 657, 711, 787, 846, 1512, 1525, 1560, 1668, 1695, 1818, 1860, 1908, 1957, 1982, 1990, 2125, 2135, 2140, 2229, 2300, 2332, 2338, 3516, 4617], 'the': [5, 26, 107, 129, 159, 176, 197, 278, 300, 330, 350, 365, 395, 432, 456, 460, 558, 580, 594, 619, 693, 881, 976, 1081, 1111, 1209, 1236, 1282, 1287, 1323, 1510, 1638, 1682, 1735, 1853, 1872, 1891, 1897, 1903, 2005, 2056, 2087, 2154, 2157, 2207, 2249, 2258, 2414, 2504, 2535, 2564, 2573, 2601, 2704, 2762, 2779, 2818, 2829, 2839, 2851, 2869, 2883, 2897, 2910, 2918, 2923, 2938, 2963, 2974, 2987, 3006, 3013, 3019, 3033, 3040, 3342, 3375, 3382, 3445, 3466, 3517, 3539, 3545, 3555, 3664, 3692, 3736, 3743, 3770, 3807, 3834, 3840, 3854, 3865, 3869, 3898, 3993, 4044, 4076, 4085, 4128, 4143, 4163, 4230, 4261, 4288, 4332, 4338, 4348, 4418, 4427, 4448, 4451, 4454, 4460, 4464, 4493, 4503, 4506, 4512, 4551, 4573, 4640, 4658, 4708, 4737, 4772, 4888, 5031, 5071, 5077, 5093, 5096, 5110, 5126, 5137, 5209, 5366, 5401, 5450, 5461, 5481, 5487, 5502, 5513, 5517, 5542], 'lysine': [6, 10, 41, 43, 110, 114, 117, 138, 165, 168, 177, 181, 212, 214, 281, 285, 288, 309, 336, 339, 477, 487, 490, 715, 723, 765, 788, 790, 806, 825, 836, 872, 891, 915, 936, 954, 957, 1200, 1203, 1334, 1338, 1470, 1616, 2038, 2344, 2375, 2445, 2476, 2548, 2604, 2639, 3046, 3052, 3096, 3116, 3267, 3303, 3376, 3425, 3738, 3782, 3796, 3800, 3821, 3835, 3860, 3871, 3899, 3919, 3937, 3951, 3972, 3999, 4010, 4013, 4021, 4055, 4169, 4219, 4244, 4252, 4272, 4368, 4396, 4404, 4414, 4428, 4431, 4474, 4477, 4494, 4497, 4513, 4516, 4535, 4538, 4575, 4578, 4585, 4598, 4602, 4630, 4633, 4661, 4696, 4865, 5012, 5015, 5018, 5389, 5457, 5490, 5493, 5497, 5507, 5531, 5534], 'residue,': [7, 178, 716, 837, 2532, 3872], 'such': [8, 179, 3291, 5099, 5545], 'as': [9, 180, 808, 938, 2045, 2346, 2377, 2991, 3118, 3175, 3292, 3420, 3974, 5046, 5485, 5501, 5546], 'methylation,': [11, 182, 718, 4699], 'acetylation,': [12, 183, 719, 5019], 'and': [13, 18, 53, 67, 76, 87, 95, 116, 123, 157, 167, 184, 189, 224, 238, 247, 258, 266, 287, 294, 328, 338, 344, 362, 373, 465, 505, 511, 521, 608, 640, 665, 676, 695, 720, 741, 854, 883, 906, 917, 922, 928, 947, 956, 1016, 1020, 1059, 1066, 1074, 1089, 1101, 1184, 1195, 1202, 1303, 1309, 1374, 1382, 1409, 1466, 1502, 1519, 1540, 1558, 1612, 1713, 1772, 1830, 1876, 1902, 1911, 1919, 1943, 1985, 2037, 2063, 2076, 2090, 2128, 2199, 2227, 2245, 2298, 2335, 2358, 2409, 2454, 2511, 2581, 2589, 2635, 2679, 2792, 2877, 2890, 2901, 2967, 3002, 3060, 3071, 3076, 3084, 3098, 3188, 3345, 3352, 3395, 3512, 3594, 3633, 3799, 3909, 3922, 4012, 4153, 4178, 4200, 4207, 4227, 4358, 4377, 4430, 4446, 4476, 4496, 4515, 4561, 4577, 4601, 4607, 4627, 4632, 4650, 4666, 4680, 4698, 4700, 4726, 4752, 4770, 4948, 4970, 4977, 4992, 4999, 5014, 5023, 5049, 5085, 5145, 5169, 5206, 5226, 5290, 5304, 5329, 5357, 5412, 5429, 5435, 5456, 5492, 5499, 5524], 'ubiquitination,': [14, 185], 'are': [15, 186, 346, 450, 503, 1923, 2765, 2821, 4480, 4728, 5299, 5325, 5478], 'diverse,': [16, 187], 'abundant,': [17, 188, 853, 2355], 'dynamic.': [19, 190], 'They': [20, 191, 5298], 'play': [21, 192, 729], 'a': [22, 37, 85, 104, 151, 193, 208, 256, 275, 322, 356, 382, 678, 782, 809, 829, 839, 843, 870, 886, 902, 939, 950, 1274, 1327, 1336, 1432, 1474, 1579, 1620, 1803, 1819, 1833, 1840, 1882, 2136, 2164, 2176, 2185, 2315, 2347, 2378, 2418, 2422, 2458, 2467, 2479, 2527, 2530, 2545, 2596, 2643, 2672, 2720, 2807, 2864, 2929, 2933, 2978, 2994, 2998, 3003, 3119, 3172, 3287, 3421, 3430, 3434, 3450, 3453, 3458, 3471, 3564, 3569, 3573, 3675, 3679, 3683, 3705, 3747, 3755, 3775, 3829, 3845, 3874, 3881, 3953, 3975, 4054, 4089, 4108, 4115, 4121, 4138, 4150, 4155, 4158, 4222, 4243, 4292, 4312, 4319, 4325, 4343, 4355, 4360, 4363, 4413, 4612, 4796, 5047, 5053, 5162, 5421, 5538], 'key': [23, 194], 'role': [24, 195, 732, 4623], 'in': [25, 92, 121, 124, 196, 263, 292, 295, 355, 376, 586, 690, 733, 739, 835, 875, 920, 926, 929, 983, 985, 1068, 1080, 1208, 1230, 1259, 1291, 1362, 1496, 1645, 1750, 1758, 1765, 1816, 1852, 1871, 1940, 1948, 2084, 2143, 2158, 2175, 2184, 2493, 2578, 2592, 2767, 2823, 2863, 2887, 2906, 2942, 2964, 3014, 3022, 3039, 3054, 3091, 3144, 3171, 3191, 3213, 3251, 3297, 3415, 3438, 3456, 3476, 3486, 3543, 3563, 3668, 3820, 4002, 4023, 4049, 4127, 4149, 4154, 4221, 4225, 4247, 4266, 4331, 4354, 4359, 4399, 4436, 4443, 4482, 4499, 4507, 4519, 4522, 4542, 4605, 4608, 4624, 4639, 4647, 4663, 4683, 4733, 4799, 4811, 4905, 4967, 4984, 5021, 5024, 5030, 5101, 5109, 5156, 5208, 5384, 5398, 5424, 5486, 5541, 5549], 'regulation': [27, 198, 4649], 'of': [28, 36, 40, 71, 78, 106, 131, 134, 154, 199, 207, 211, 242, 249, 277, 302, 305, 325, 352, 364, 380, 386, 390, 434, 459, 508, 560, 591, 597, 638, 697, 703, 714, 763, 785, 805, 831, 885, 889, 904, 942, 975, 1076, 1191, 1225, 1235, 1253, 1277, 1415, 1469, 1516, 1574, 1615, 1687, 1822, 1885, 2049, 2138, 2147, 2156, 2179, 2191, 2238, 2243, 2248, 2270, 2350, 2374, 2398, 2417, 2603, 2638, 2675, 2739, 2781, 2789, 2798, 2810, 2817, 2827, 2871, 2885, 2912, 2920, 2977, 2993, 3005, 3029, 3036, 3115, 3146, 3216, 3384, 3484, 3514, 3538, 3576, 3597, 3625, 3656, 3671, 3686, 3694, 3712, 3772, 3780, 3790, 3806, 3838, 3853, 3902, 3936, 3940, 3971, 4034, 4047, 4079, 4088, 4111, 4117, 4130, 4204, 4232, 4264, 4291, 4315, 4321, 4334, 4373, 4434, 4505, 4660, 4717, 4722, 4951, 5034, 5044, 5055, 5058, 5095, 5098, 5112, 5128, 5139, 5148, 5195, 5211, 5230, 5243, 5368, 5382, 5395, 5404, 5431, 5449, 5489, 5496, 5527, 5530], 'diverse': [29, 200, 709, 761, 5550], 'cellular': [30, 201, 371, 509, 519, 734, 3781, 5113, 5234, 5396, 5405, 5468, 5543], 'physiology.': [31, 202, 5235], 'Here': [32, 203, 878], 'we': [33, 100, 204, 271, 780, 879, 933, 1434, 2393, 2412, 2432, 2495, 2594, 2663, 2722, 2945, 3049, 3233, 3305, 3653, 3659, 3812, 3827, 3896, 3955, 4051, 4236, 4268, 4389, 4438, 4510, 4565, 4591, 4656, 4944, 5080], 'report': [34, 205, 880], 'discovery': [35, 206], 'new': [38, 152, 209, 323, 783, 810, 887, 899, 940, 2348, 2379, 2865, 2934, 3120, 3976, 5539], 'type': [39, 153, 210, 324, 784, 888, 941, 2349], 'PTM,': [42, 213, 583, 890], 'malonylation': [44, 166, 215, 337, 892, 937, 955, 2039, 2590, 3053, 3246, 3268, 3426, 4475, 4514, 4536, 4576, 4662, 4688, 5013, 5390, 5498, 5508, 5535], '(Kmal).': [45, 216], 'Kmal': [46, 80, 83, 217, 251, 254, 1402, 1567, 1746, 2095, 2430, 2491, 2531, 2574, 2587, 2669, 2686, 2706, 2830, 2886, 2939, 2949, 3362, 3657, 3676, 3776, 4063, 4223], 'was': [47, 59, 218, 230, 981, 1036, 1228, 1239, 1257, 1279, 1289, 1392, 1417, 1427, 1494, 1507, 1522, 1548, 1677, 1756, 1894, 1900, 1906, 1917, 1955, 1963, 2104, 2263, 2295, 2312, 2438, 2712, 3178, 3248, 3269, 3327, 3849, 4125, 4146, 4329, 4351, 4525, 4671, 4746, 4789, 4809, 4898, 5186], 'initially': [48, 219, 4956], 'detected': [49, 220, 2413, 2449, 2517, 2562, 4126, 4148, 4330, 4353, 4810], 'by': [50, 62, 221, 233, 349, 603, 708, 1096, 1216, 1241, 1321, 1343, 1404, 1419, 1429, 1473, 1504, 1536, 1542, 1551, 1619, 1666, 1680, 1737, 1965, 1997, 2033, 2266, 2401, 2524, 2642, 2690, 2698, 2742, 2833, 3045, 3058, 3093, 3169, 3255, 3271, 3300, 3350, 3368, 3418, 3520, 3536, 3702, 3787, 4182, 4381, 4529, 4673, 4986, 5121, 5131, 5142, 5165, 5175, 5247, 5307, 5332], 'mass': [51, 222, 411, 537, 1410, 1837, 2749, 2808, 3034, 3436, 3490, 3521, 3549, 3565, 3684, 3763, 4072, 4109, 4313, 5289], 'spectrometry': [52, 223, 4073], 'protein': [54, 145, 225, 316, 407, 466, 533, 578, 606, 923, 1024, 1390, 1413, 1425, 1492, 1575, 1690, 2015, 2027, 2242, 2410, 2699, 2744, 3322, 4441, 4484, 4552, 4625, 4751, 4884, 4889, 4978, 5041], 'sequence-database': [55, 226], 'searching.': [56, 227], 'The': [57, 228, 360, 653, 700, 760, 973, 1044, 1212, 1233, 1316, 1370, 1389, 1412, 1424, 1491, 1531, 1546, 1566, 1704, 1729, 1744, 1752, 1825, 1863, 1887, 1959, 2083, 2145, 2171, 2261, 2292, 2310, 2684, 2692, 2954, 3332, 3359, 3778, 4173, 4711, 4917, 4953, 4966, 4980, 5379], 'modification': [58, 229, 486, 654, 900, 3627, 4670], 'comprehensively': [60, 231], 'validated': [61, 232, 4672], 'Western': [63, 234, 1249, 1345, 1396, 2497, 2872, 3256, 4469, 4674, 4987], 'blot,': [64, 235, 1250, 4675], 'tandem': [65, 236, 492, 2748], 'MS,': [66, 237], 'high-performance': [68, 239], 'liquid': [69, 240, 481, 496], 'chromatography': [70, 241], 'synthetic': [72, 243, 1328, 2088, 2148, 2169, 2914, 2969, 2995, 3020, 3066, 3672, 3846, 4060, 4090, 4277, 4293, 4681], 'peptides,': [73, 244, 2431, 3658], 'isotopic': [74, 245, 1030, 1354, 3312], 'labeling,': [75, 246], 'identification': [77, 248, 882, 2718, 2780, 3383, 3593, 3771, 4659], 'multiple': [79, 250, 2557, 4483], 'substrate': [81, 252, 671, 698, 3848, 4709, 4741], 'proteins.': [82, 253, 699, 4710, 4965, 5103], 'is': [84, 255, 367, 584, 705, 851, 949, 2353, 2576, 2922, 3043, 3296, 3442, 3533, 3558, 3700, 3784, 3991, 4027, 4095, 4229, 4298, 4702, 4736, 4890, 4922, 5076, 5105, 5116, 5245, 5420, 5441, 5471, 5509], 'dynamic': [86, 257, 2359, 5402], 'evolutionarily': [88, 259, 855, 943, 2356], 'conserved': [89, 260, 856, 944], 'PTM': [90, 155, 261, 326, 786, 850, 945, 2360, 2575, 2919, 3431, 3446, 3954, 5452, 5483], 'observed': [91, 262], 'mammalian': [93, 264, 860, 876, 2580, 2889, 4665], 'cells': [94, 265, 378, 1350, 1371, 3094, 3170, 3237, 3301, 3308, 3419, 5157, 5444], 'bacterial': [96, 267, 2582, 2891, 4667], 'cells.': [97, 268, 861, 877, 2513, 2583, 2892, 4668], 'In': [98, 269, 2660, 3011, 3842, 4007, 4141, 4346, 4653, 4877, 4941, 5178], 'addition,': [99, 270, 3012], 'demonstrate': [101, 272], 'that': [102, 162, 273, 333, 864, 911, 2153, 2518, 2572, 2804, 2928, 2992, 3032, 3163, 3266, 3295, 3326, 3386, 3403, 3441, 3661, 3698, 3707, 3814, 3915, 3923, 3996, 4135, 4215, 4239, 4340, 4392, 4473, 4489, 4534, 4567, 4594, 4791, 4887, 5005, 5063, 5082, 5388, 5443, 5474], 'Sirt5,': [103, 274, 4102, 4306, 4727], 'member': [105, 276], 'class': [108, 136, 279, 307, 4185, 4197, 4712], 'III': [109, 137, 280, 308, 4186, 4713], 'deacetylases,': [111, 139, 282, 310], 'can': [112, 163, 283, 334, 599, 913, 2560, 3078, 3088, 3283, 3364, 3405, 3765, 4179, 4217, 4241, 4378, 4394, 4491, 4596, 5153], 'catalyze': [113, 284, 914, 4218, 4242, 4395, 4492, 4597], 'demalonylation': [115, 286, 916, 1201, 3836, 3861, 3900, 3920, 3931, 3938, 4011, 4056, 4077, 4174, 4220, 4245, 4369, 4429, 4495, 4599, 4947, 4969, 5048, 5084], 'desuccinylation': [118, 289, 918, 1204, 4000, 4014, 4262, 4273, 4371, 4397, 4432, 4603, 4949, 4971, 5050, 5086], 'reactions': [119, 290, 2172, 4274, 4398], 'both': [120, 291, 925, 2579, 2888, 4604, 4664, 4695, 4996, 5020], 'vitro': [122, 293, 4226, 4248, 4400, 4508, 4606, 4906, 4968, 5022], 'vivo.': [125, 296, 4609, 5025], 'This': [126, 297, 849, 2775, 3378, 3532, 3761, 3912, 4212, 4486, 4669], 'result': [127, 298, 3264, 4213, 4487, 4504, 5089], 'suggests': [128, 299, 5052], 'possibility': [130, 301, 5054, 5094], 'nondeacetylation': [132, 303, 5056], 'activity': [133, 304, 3837, 3862, 3901, 3932, 3939, 4001, 4019, 4263, 4372, 4755, 4904, 5250], 'other': [135, 306, 3055, 4250, 4402, 5059, 5072, 5102, 5521], 'especially': [140, 311, 5061], 'those': [141, 312, 5062], 'without': [142, 313], 'obvious': [143, 314, 4806, 5039], 'acetylation': [144, 315, 1471, 1617, 2605, 2640, 3097, 3143, 3783, 4586, 4634, 4697, 5491], 'substrates.': [146, 317, 4979, 5042, 5069], 'Our': [147, 318, 3263], 'results': [148, 319, 2057, 2570, 2840, 2852, 2870, 3401], 'therefore': [149, 320, 4701], 'reveal': [150, 321], 'pathway': [156, 327, 946], 'identify': [158, 329, 2585, 2703], 'first': [160, 331, 3234, 3741, 5078, 5503, 5514], 'enzyme': [161, 332, 952, 5051, 5079, 5505], 'regulate': [164, 335], 'succinylation': [169, 340, 791, 807, 826, 2345, 2376, 3099, 3117, 3973, 4478, 4498, 4517, 4539, 5016, 5455], 'status.': [170, 341], 'Cellular': [342], 'function': [343], 'physiology': [345], 'largely': [347], 'determined': [348], 'inventory': [351], 'all': [353, 517, 2828, 3663, 3805, 3839, 3903], 'proteins': [354, 1063, 2786, 2797, 4449], 'cell,': [357], 'its': [358, 670, 1060, 1090, 2168, 2450, 2525, 2968, 3924, 4754, 5467], 'proteome.': [359], 'collection': [361], 'characterization': [363, 5526], 'proteome': [366, 435, 561], 'critical': [368, 5380], 'to': [369, 684, 728, 842, 859, 1264, 1269, 1281, 1313, 1509, 1789, 1808, 1878, 2070, 2099, 2107, 2206, 2257, 2440, 2667, 2702, 2714, 2778, 2815, 2926, 3286, 3338, 3381, 3408, 3464, 3470, 3568, 3691, 3754, 3832, 3944, 4009, 4074, 4133, 4337, 4453, 4544, 4704, 4730, 4743, 4748, 4900, 5011, 5118, 5173, 5180, 5189, 5400, 5465, 5511], 'understanding': [370], 'mechanisms': [372, 453, 507, 637], 'diseases.': [374], 'Proteomes': [375], 'eukaryotic': [377], 'consist': [379], 'over': [381, 2111, 3374], 'million': [383], 'molecular': [384, 4086, 4289], 'species': [385], 'proteins,': [387, 593, 2593, 4437], 'easily': [388, 3365, 3561], 'orders': [389], 'magnitude': [391], 'more': [392, 587, 673, 868, 4690, 5295], 'complex': [393, 504], 'than': [394, 500, 588, 869, 4694, 5017], 'corresponding': [396, 2536, 2913, 3065, 4132, 4336, 4419], 'genomes': [397], '(1Witze': [398, 524], 'E.S.': [399, 525], 'Old': [400, 526], 'W.M.': [401, 527], 'Resing': [402, 528], 'K.A.': [403, 529], 'Ahn': [404, 530], 'N.G.': [405, 531], 'Mapping': [406, 532, 3623], 'with': [410, 515, 536, 1300, 1305, 1326, 1353, 1377, 1385, 1684, 1701, 1710, 1715, 1741, 1769, 1802, 1855, 1881, 2058, 2120, 2329, 2529, 2563, 2747, 2917, 2997, 3018, 3238, 3259, 3273, 3309, 3330, 3389, 3572, 3682, 3792, 3851, 3859, 4101, 4107, 4305, 4311, 4463, 4611, 4685, 5557], 'spectrometry.Nat.': [412, 538], 'Methods.': [413, 539, 621, 1083, 1211, 1232], '2007;': [414, 540, 748, 4869], '4:': [415, 541, 2754], '798-806Crossref': [416, 542], 'PubMed': [417, 444, 543, 570, 625, 648, 751, 774, 818, 1486, 1632, 2387, 2655, 2756, 3128, 3156, 3199, 3224, 3499, 3527, 3606, 3647, 3984, 4783, 4872, 4936, 5217, 5273, 5342], 'Scopus': [418, 445, 544, 571, 626, 649, 752, 775, 819, 1487, 1633, 2388, 2656, 2757, 3129, 3157, 3200, 3225, 3500, 3528, 3607, 3648, 3985, 4784, 4873, 4937, 5218, 5274, 5343], '(611)': [419, 545], 'Google': [420, 447, 546, 573, 628, 651, 754, 777, 821, 1489, 1635, 2390, 2658, 2759, 3131, 3159, 3202, 3227, 3502, 3530, 3609, 3650, 3987, 4786, 4875, 4939, 5220, 5276, 5345, 5377], 'Scholar,': [421, 547, 629, 755, 3132, 3203, 3503, 3610], '2Walsh': [422, 548], 'C.T.': [423, 549], 'Garneau-Tsodikova': [424, 550], 'S.': [425, 551, 4853], 'Gatto': [426, 552], 'Jr.,': [427, 553, 5360], 'G.J.': [428, 554], 'posttranslational': [430, 556], 'modifications:': [431, 557], 'chemistry': [433, 559], 'diversifications.Angew': [436, 562], 'Chem.': [437, 563, 643, 813, 2382, 3123, 3979], 'Int.': [438, 564], 'Ed': [439, 565], 'Engl.': [440, 566], '2005;': [441, 567, 622, 771, 2753], '44:': [442, 568], '7342-7372Crossref': [443, 569], '(1055)': [446, 572], 'Scholar).': [448, 574, 652, 778, 822, 1490, 1636, 2391, 2659, 2760, 3160, 3228, 3531, 3651, 3732, 3988, 4787, 4876, 4940, 5221, 5277, 5346, 5378], 'There': [449], 'two': [451, 832, 3007, 3027, 3788, 4403, 4802, 5451, 5482], 'major': [452, 4797, 5123], 'for': [454, 617, 953, 1072, 1086, 1198, 1367, 1395, 1400, 1528, 1563, 1672, 1698, 1890, 1925, 1931, 1937, 1945, 1952, 1977, 1986, 2093, 2232, 2303, 2429, 2600, 2736, 2951, 3095, 3242, 3302, 3317, 3356, 3424, 3631, 3768, 3878, 4120, 4196, 4249, 4324, 4401, 4412, 4417, 4801, 5365, 5506, 5516, 5520, 5525], 'expanding': [455], 'coding': [457], 'capacity': [458], 'human': [461, 592, 605, 2014, 4208, 4896, 4918], 'genome:': [462], 'mRNA': [463], 'splicing': [464], '1The': [470], 'abbreviations': [471], 'used': [472, 1393, 2595, 2664, 2713, 3090, 3168, 3299, 3417, 3767, 4071], 'are:PTMProtein': [473], 'modificationKATlysine': [475], 'acetyltransferaseHDACHistone': [476], 'deacetylaseMS/MStandem': [478], 'MSHPLChigh': [479], 'performance': [480, 495], 'chromatography.': [482, 497], '.': [483], 'acetyltransferase': [488], 'Histone': [489], 'deacetylase': [491, 3810, 4798, 4903], 'MS': [493, 1845, 2834], 'high': [494, 701, 2072, 2442, 3288, 4031, 5308], 'PTMs': [498, 704, 724], '(more': [499], '300': [501], 'types)': [502], 'fundamental': [506], 'regulation,': [510, 5544], 'have': [512, 725, 2071, 2441, 3433, 3678, 3809, 3929, 4635, 4705, 4901, 5038, 5066, 5190, 5414], 'been': [513, 726, 4636], 'associated': [514], 'almost': [516, 3662], 'known': [518, 4729, 5067, 5117], 'pathways': [520, 5111, 5453], 'disease': [522], 'processes': [523], 'As': [575, 2971, 4082, 4285, 5222], 'an': [576, 730, 1332, 1513, 1553, 1775, 1790, 2354, 2405, 2434, 2483, 2972, 3369, 3409, 3487, 3889, 4083, 4103, 4167, 4194, 4286, 4307, 4621, 4891, 4923, 5106, 5182, 5223, 5240, 5351], 'example,': [577, 2973, 3449, 4084, 4287, 5237], 'phosphorylation,': [579], 'most': [581, 1865], 'well-studied': [582], 'present': [585, 2577], 'one': [589, 2189, 5448], 'third': [590], 'phosphorylation': [595, 668, 3454], 'status': [596, 3247, 3779, 4518], 'which': [598, 689, 2437, 3087, 3412, 3689, 3751, 4026, 4523, 5035], 'potentially': [600], 'be': [601, 867, 2520, 2561, 3079, 3089, 3167, 3284, 3366, 3406, 3414, 3766, 3818, 4180, 4379, 4731, 4795, 5119, 5154, 5512], 'regulated': [602, 3786], '∼500': [604], 'kinases': [607], '∼150': [609], 'phosphatases': [610], '(3Johnson': [611], 'S.A.': [612, 3505], 'Hunter': [613], 'T.': [614, 1450, 1596, 2619, 4757], 'Kinomics:': [615], 'methods': [616], 'deciphering': [618], 'kinome.Nat.': [620], '2:': [623, 646, 3222], '17-25Crossref': [624], '(349)': [627], '4Denu': [630], 'J.M.': [631, 3618, 4914], 'Dixon': [632], 'J.E.': [633], 'tyrosine': [635], 'phosphatases:': [636], 'catalysis': [639], 'regulation.Curr.': [641], 'Opin.': [642, 5371], 'Biol.': [644, 747, 770, 814, 2383, 3124, 3980, 4868], '1998;': [645, 3496], '633-641Crossref': [647], '(336)': [650], 'mainly': [655, 3534], 'occurs': [656, 3709], 'several': [658], 'amino': [659, 970, 978, 5438], 'acid': [660, 971, 979, 1116, 1119, 1124, 1422, 1764, 1815, 3211, 3714, 5160, 5167, 5284], 'residues:': [661], 'serine,': [662], 'threonine,': [663], 'tyrosine,': [664], 'histidine.': [666], 'makes': [669], 'residues': [672, 980, 4064, 4281], 'acidic,': [674], 'hydrophilic,': [675], 'induces': [677, 828, 4689], 'charge': [679, 683, 841, 845], 'change': [680, 830], 'from': [681, 838, 857, 997, 1004, 1010, 1018, 1027, 1038, 1051, 1110, 1571, 1734, 1806, 2167, 2421, 2508, 2671, 2784, 2795, 2835, 2981, 3323, 3868, 4030, 4093, 4296, 4450, 4554, 4557, 4995], '+1': [682, 840], '–1': [685, 844], '(at': [686], 'physiological': [687, 847, 4618], 'pH),': [688], 'turn': [691, 3092, 3298, 3416], 'modulates': [692], 'structure': [694], 'functions': [696, 762, 4626, 5529], 'complexity': [702], 'also': [706, 827, 3050, 3166, 3559, 4237, 4269, 4390, 5187, 5300, 5472], 'reflected': [707], 'ε-amine': [712], 'group': [713, 3000, 3557, 3757, 3867], 'including': [717, 988], 'ubiquitination.': [721], 'These': [722, 2569, 3026, 3400, 4531, 5347], 'shown': [727, 2439, 4747, 5188], 'important': [731, 4622, 4645, 4892, 5107, 5183, 5224], 'regulations': [735, 5397], '(5Guarente': [736], 'L.': [737, 799, 1456, 1602, 2368, 2625, 3109, 3612, 3965, 4763, 5313], 'Sirtuins': [738], 'aging': [740], 'disease.Cold': [742], 'Spring': [743], 'Harb.': [744], 'Symp': [745], 'Quant': [746], '72:': [749], '483-488Crossref': [750], '(292)': [753], '6Martin': [756], 'C.': [757, 3719], 'Zhang': [758], 'Y.': [759, 801, 803, 1442, 1444, 1452, 1464, 1588, 1590, 1598, 1610, 2370, 2372, 2611, 2613, 2621, 2633, 2726, 2732, 3111, 3113, 3967, 3969, 4838, 4840], 'histone': [764, 3142], 'methylation.Nat.': [766], 'Rev.': [767], 'Mol.': [768], 'Cell': [769, 4867], '6:': [772], '838-849Crossref': [773], '(1615)': [776], 'Recently,': [779], 'identified': [781, 2343, 2741, 2819, 2832, 2941, 3367, 4742, 4957, 5081], 'residues,': [789], '(7Zhang': [792, 2361, 3102, 3958], 'Z.': [793, 797, 2362, 2366, 3103, 3107, 3580, 3959, 3963], 'Tan': [794, 2363, 3104, 3960], 'M.': [795, 1460, 1606, 2364, 2629, 3105, 3961, 4846], 'Xie': [796, 2365, 3106, 3962], 'Dai': [798, 2367, 3108, 3964], 'Chen': [800, 1441, 1587, 2369, 2610, 3110, 3966, 4839], 'Zhao': [802, 1463, 1609, 2371, 2632, 2731, 3112, 3968], 'Identification': [804, 2373, 3114, 3970, 5043, 5495], 'modification.Nat.': [812, 2381, 3122, 3978], '2011;': [815, 2384, 3125, 3981, 5214], '7:': [816, 2385, 3126, 3982], '58-63Crossref': [817, 2386, 3127, 3983], '(588)': [820, 2389, 3130, 3986], 'Like': [823, 4367], 'phosporylation,': [824], 'negative': [833], 'charges': [834], 'pH.': [848], 'dynamic,': [852], 'bacteria': [858], 'We': [862, 895, 909, 2341, 3161, 3320, 3696, 4070, 4457, 5002], 'anticipate': [863], 'there': [865], 'will': [866, 2895, 3887], 'thousand': [871], 'succinylated': [873, 2475, 2539, 2547, 4405], 'substrates': [874, 2400, 2588, 3886, 4254, 4406], 'verification': [884, 2711, 2738], '(Fig.': [893, 1244, 2486, 2549, 3009, 3024, 3276, 3393, 3933, 4005, 4097, 4210, 4301, 4467, 4587], '1).': [894], 'extensively': [896, 4637], 'confirmed': [897, 3031, 3051, 4974, 4983], 'this': [898, 2661, 3231, 3699, 3734, 3825, 3843, 3894, 4003, 4024, 4080, 4233, 4654, 4750, 4942, 5088], 'using': [901, 965, 1220, 1406, 1431, 1578, 1839, 2404, 2500, 2719, 2880, 2960, 3063, 3341, 3628, 4058, 4157, 4275, 4362, 4958, 4961, 4975, 4989], 'variety': [903], 'chemical': [905, 2952], 'biochemical': [907], 'methods.': [908], 'showed': [910, 3265, 3914, 4017, 4391, 4472, 4566, 4945, 5004], 'Sirt5': [912, 948, 1048, 1058, 1077, 1087, 3916, 3941, 3990, 4016, 4048, 4159, 4216, 4240, 4265, 4364, 4374, 4393, 4435, 4462, 4490, 4524, 4545, 4559, 4562, 4568, 4595, 4745, 4792, 4897, 5006, 5045, 5075, 5500], 'reactions,': [919, 3100], 'peptide': [921, 1278, 1329, 1754, 2096, 2160, 2420, 2452, 2455, 2464, 2481, 2528, 2542, 2717, 2931, 2966, 2979, 2996, 3016, 3021, 3353, 3357, 3665, 4134, 4145, 4165, 4224, 4339, 4350, 4976], 'substrates,': [924], 'vivo': [927, 2085, 2159, 2965, 3015, 4985], 'vitro.': [930, 4500], 'Taken': [931, 2867, 4589], 'together,': [932, 2868, 4590], 'conclusively': [934], 'establish': [935], 'regulatory': [951, 5191, 5227, 5476, 5504, 5522], 'succinylation.': [958], 'Peptides': [959, 3428], 'were': [960, 995, 1049, 1064, 1078, 1094, 1108, 1206, 1214, 1319, 1341, 1351, 1372, 1534, 1569, 1643, 1664, 1706, 1732, 1748, 1800, 1828, 1850, 1868, 1929, 1980, 1988, 1995, 2007, 2043, 2053, 2067, 2097, 2118, 2133, 2150, 2161, 2173, 2204, 2255, 2516, 2688, 2696, 2841, 2853, 2957, 3336, 3348, 3387, 4540, 4955, 4973, 4982, 5028], 'synthesized': [961, 1215, 5120], 'through': [962, 3746, 5158, 5170], 'custom': [963, 1218], 'synthesis': [964, 974, 1190, 1219], 'racemic': [966], 'or': [967, 1335, 1399, 2021, 2193, 2307, 2478, 2541, 3460, 3548, 4162, 4386, 4527, 4537, 4813], 'enantiomeric': [968], 'protected': [969, 977, 5301, 5326], 'residues.': [972], 'described': [982, 1229, 1435, 1581, 2599, 2724], 'detail': [984], 'supplementary': [986, 1082, 1210, 1231, 2768, 3396], 'Methods,': [987], 'Fmoc-Lys(mono-tert-butyl': [989], 'malonate)-OH,': [990], 'Fmoc-Lys(succinyl)-OH.': [991], 'Ni-NTA': [992], 'agarose': [993, 1693], 'beads': [994, 1026, 1694, 1705, 1736], 'purchased': [996, 1037, 1050], 'Qiagen': [998], '(Valencia,': [999], 'CA);': [1000], 'modified': [1001, 1337, 3870], 'sequencing-grade': [1002], 'trypsin': [1003, 1430, 1555, 2271], 'Promega': [1005], '(Madison,': [1006], 'WI);': [1007], 'C18': [1008, 1770, 1779], 'ZipTips': [1009, 1771], 'Millipore': [1011], 'Corporation': [1012], '(Billerica,': [1013], 'MA);': [1014], 'water': [1015], 'acetonitrile': [1017], 'Burdick': [1019], 'Jackson': [1021], '(Meskegon,': [1022], 'MI);': [1023], 'A': [1025, 1155, 1691, 1761, 2708, 3190, 3857, 4192, 5133, 5265], 'GE': [1028], 'Healthcare;': [1029], '[1,': [1031, 1356, 3314, 3390], '2,': [1032, 1357, 1901, 3315, 3391], '3-13C]': [1033, 1358], 'sodium': [1034, 1133, 1355, 3274, 3313], 'malonate': [1035, 1359, 3164, 3241, 3275, 3282, 3404], 'Cambridge': [1039], 'Isotope': [1040], 'Laboratories': [1041], '(Andover,': [1042], 'MA).': [1043], 'recombinant': [1045, 4461, 4963], 'HDACs': [1046, 2202, 3808, 3816, 3905, 5027], 'except': [1047], 'BPS': [1052], 'Bioscience': [1053], '(San': [1054], 'Diego,': [1055], 'CA).': [1056], 'Wt': [1057], 'inactive': [1061, 1091, 3925, 4160], 'mutant': [1062, 1092, 3926, 4161, 5323], 'expressed': [1065], 'purified': [1067], 'house.': [1069], 'Experimental': [1070], 'procedure': [1071, 1433, 1580, 2721], 'expression': [1073, 4546], 'purification': [1075, 1676], 'included': [1079, 1207, 2766], 'Expression': [1084], 'plasmids': [1085], 'wt': [1088, 4558], '(H158Y)': [1093], 'constructed': [1095], 'Wei': [1097], 'Gu': [1098], '(Columbia': [1099], 'University)': [1100], 'Eric': [1102], 'Verdin': [1103, 4854, 4915], '(UCSF),': [1104], 'respectively.': [1105], 'Other': [1106], 'chemicals': [1107], 'obtained': [1109, 1641], 'following': [1112], 'suppliers:': [1113], 'Sigma-Aldrich:': [1114], 'trifluoroacetic': [1115], '(99%),': [1117], 'formic': [1118, 1763, 1814], '(>98%),': [1120], 'NH4HCO3': [1121, 1499], '(>99%),': [1122], 'trichloroacetic': [1123, 1421], '(6.1': [1125], 'N),': [1126], 'iodoacetamide,': [1127, 2034], 'dithothreitol,': [1128], 'bovine': [1129], 'serum': [1130], 'albumin': [1131], '(BSA),': [1132], 'dodecyl': [1134], 'sulfate,': [1135], 'Tris-Cl,': [1136, 1650, 1720, 2212], 'MgCl2': [1137], '(ACS': [1138, 1141, 1144, 1152, 1158, 1162, 1165, 1174, 1177, 1180, 1187], 'grade),': [1139, 1142, 1145, 1153, 1163, 1166, 1169, 1175, 1178, 1181], 'NaCl': [1140], 'KCl': [1143], 'β-nicotinamide': [1146], 'adenine': [1147], 'dinucleotide': [1148], 'hydrate': [1149], '(NAD+),': [1150], 'nicotinamide': [1151, 4183], 'trichostatin': [1154, 4191], '(TSA),': [1156], 'sirtinol': [1157, 4201], 'grade);': [1159], 'Fisher:': [1160], 'NaHCO3': [1161], 'NaOH': [1164], 'CH3CN': [1167], '(HPLC': [1168], 'HCl': [1170], 'solution': [1171, 2196, 2252, 2272], '(37.3%),': [1172], 'glycine': [1173], 'MeOH': [1176], 'acetone': [1179], 'DMEM': [1182, 1363], 'medium': [1183], 'hydrogen': [1185], 'peroxide': [1186], 'grade).': [1188], 'Chemical': [1189], 'Fmoc-Lys': [1192, 1221], '(mono-tert-butyl': [1193, 1222], 'malonate)-OH': [1194], 'fluorescent': [1196], 'compounds': [1197], 'assaying': [1199, 2236], 'activities': [1205, 2237, 3949, 4033, 4046, 4433, 4950, 4954, 4972, 4981, 5010, 5057, 5100], 'peptides': [1213, 1403, 1533, 1568, 1640, 1683, 1731, 1747, 1827, 2149, 2670, 2687, 2740, 2783, 2794, 2820, 2831, 2894, 2915, 2940, 2950, 2956, 3008, 3057, 3067, 3335, 3347, 3363, 3673, 3773, 4061, 4278, 4421, 4682], 'commercial': [1217], 'malonate)-OH.': [1223], 'Generation': [1224], 'anti-Kmal': [1226, 1407, 1688, 2435, 2501, 2665, 3261, 3343], 'antibody': [1227, 1238, 1408, 1689, 2448, 2502, 2565, 2666], 'specificity': [1234, 2443], 'sequence-specific': [1237], 'demonstrated': [1240, 4533, 4593], 'dot-blot': [1242, 1272], 'assay': [1243, 3831, 3913, 4004], '2A).': [1245, 2487], 'To': [1246, 2426, 2488, 2584, 2936, 3229, 3278, 3823, 4041, 4258, 4425, 4501], 'carry': [1247, 1270, 2110], 'out': [1248, 1271, 1524, 1679, 2106, 2395, 4053, 4271], '40': [1251], 'μg': [1252, 2241], 'each': [1254, 2094, 2113, 2805, 3852], 'cell': [1255, 1576, 2506, 2791, 2983], 'lysate': [1256, 1391, 1414, 1577, 2678, 3254, 3325, 4442, 4553], 'resolved': [1258, 4439], 'gradient': [1260, 1275], 'SDS-PAGE': [1261, 4444], 'gel,': [1262], 'transferred': [1263, 4447], 'polyvinylidene': [1265], 'difluoride': [1266], '(PVDF)': [1267], 'membrane;': [1268], 'assay,': [1273, 2876, 3844, 3895, 4025, 4677], 'amount': [1276], 'spotted': [1280], 'nitrocellulose': [1283], '(NC)': [1284], 'membrane.': [1285, 4456], 'Then': [1286], 'membrane': [1288, 4466], 'blocked': [1290], 'TBST': [1292], 'buffer': [1293, 1647, 1712, 1717, 1760, 1811, 2209], '(1x': [1294], 'TBS': [1295], 'containing': [1296], '0.05%': [1297], 'Tween': [1298], '20)': [1299], '5%': [1301], 'BSA': [1302], 'probed': [1304], 'appropriate': [1306, 2308], 'primary': [1307, 1324], 'antibodies': [1308, 1311, 1325], 'secondary': [1310], 'coupled': [1312], 'horseradish': [1314], 'peroxidase.': [1315], 'competition': [1317, 2875, 4676], 'experiments': [1318, 4532, 4991], 'performed': [1320, 2174, 2496], 'incubating': [1322, 1681], 'bearing': [1330, 2457, 2466, 2482, 2544, 3429, 3452, 3674, 3774, 4062, 4166, 4279], 'either': [1331, 1394, 2010, 3457, 3544, 5447], 'unmodified': [1333, 2469, 2484, 2537], 'residue.': [1339], 'Signals': [1340], 'revealed': [1342, 1472, 1618, 2641], 'ECL': [1344], 'blot': [1346, 1397, 2498, 2873, 3257, 4470, 4988], 'detection': [1347, 3511], 'system.': [1348], 'HeLa': [1349, 2512, 2676, 2790, 2824, 2836, 2982, 3236, 3252, 3307], 'treated': [1352], '(20': [1360], 'mm': [1361, 1498, 1538, 1544, 1649, 1657, 1660, 1719, 1724, 1727, 2211, 2214, 2217, 2220, 2274, 2276, 2279, 2282, 3240, 3311], 'medium,': [1364], 'pH': [1365, 1651, 1721, 2224, 2289], '7.5)': [1366], '24': [1368, 3243, 3318], 'h.': [1369, 1530, 1565, 2234, 3244, 3319], 'harvested': [1373], 'washed': [1375, 1707], 'twice': [1376, 1714], 'ice-cold': [1378], 'phosphate-buffered': [1379], 'saline': [1380], '(PBS)': [1381], 'then': [1383, 2264, 3249, 3328, 4458], 'lysed': [1384], 'SDS': [1386], 'sample': [1387, 1755, 2109, 2114], 'buffer.': [1388, 2260], 'analysis': [1398, 2499, 2911, 3062, 3258], 'identifying': [1401], 'immunoprecipitation': [1405], 'spectrometry.': [1411], 'interest': [1416, 2244, 2921], 'precipitated': [1418], 'conventional': [1420], 'method.': [1423], 'precipitate': [1426, 1493], 'digested': [1428, 1549, 3329], 'previously': [1436, 1582, 2598, 2723, 3180, 3956], '(8Kim': [1437, 1583, 2606], 'S.C.': [1438, 1584, 2607, 2730], 'Sprung': [1439, 1585, 2608], 'R.': [1440, 1586, 2609, 3138, 4828], 'Xu': [1443, 1589, 2612], 'Ball': [1445, 1591, 2614], 'H.': [1446, 1454, 1592, 1600, 2615, 2623], 'Pei': [1447, 1593, 2616], 'J.': [1448, 1594, 2617, 3482, 3600, 4824, 4830, 5213], 'Cheng': [1449, 1595, 2618, 4821], 'Kho': [1451, 1597, 2620], 'Xiao': [1453, 1455, 1599, 1601, 2622, 2624], 'Grishin': [1457, 1603, 2626], 'N.V.': [1458, 1604, 2627], 'White': [1459, 1605, 2628], 'Yang': [1461, 1607, 2630, 4837], 'X.J.': [1462, 1608, 2631], 'Substrate': [1465, 1611, 2634], 'functional': [1467, 1613, 2636], 'diversity': [1468, 1614, 2637], 'proteomics': [1475, 1621, 2602, 2644, 2878, 4678], 'survey.Mol.': [1476, 1622, 2645], 'Cell.': [1477, 1623, 2646, 3637, 4927], '2006;': [1478, 1624, 2647], '23:': [1479, 1625, 2648], '607-618Abstract': [1480, 1626, 2649], 'Full': [1481, 1483, 1627, 1629, 2650, 2652, 3642, 3644, 4778, 4780, 4931, 4933], 'Text': [1482, 1484, 1628, 1630, 2651, 2653, 3643, 3645, 4779, 4781, 4932, 4934], 'PDF': [1485, 1631, 2654, 3646, 4782, 4935], '(1231)': [1488, 1634, 2657], 'suspended': [1495], '100': [1497, 1656, 1723], '(pH': [1500], '8.0)': [1501, 2226], 'dissolved': [1503, 1757], 'sonication.': [1505], 'Trypsin': [1506], 'added': [1508, 2205, 2256], 'mixture': [1511, 1547, 2092, 3004], 'enzyme-to-substrate': [1514], 'ratio': [1515], '1:50': [1517], '(w/w)': [1518], 'tryptic': [1520, 1532, 1639, 2673, 3334, 3883], 'digestion': [1521, 3876], 'carried': [1523, 1678, 2105, 2394, 4052, 4270], '37': [1526, 1561, 2230, 2301], '°C': [1527, 1562, 2231, 2302], '16': [1529], 'reduced': [1535, 5286], '5': [1537, 1807], 'dithothreitol': [1539], 'alkylated': [1541], '15': [1543], 'iodoacetamide.': [1545], 'again': [1550, 3992], 'adding': [1552, 2267], 'additional': [1554, 3370, 4104, 4308], '(1:100': [1556], 'w/w)': [1557], 'incubated': [1559, 2228, 2299, 3850, 4459], '3': [1564], 'enriched': [1570, 3346], 'proteolytic': [1572, 3875], 'digests': [1573], 'Briefly,': [1637, 2188], 'above': [1642, 2061], 'resolubilized': [1644], 'NETN': [1646, 1711], '(50': [1648, 1718], '8.0,': [1652, 1722], '0.5%': [1653], 'Nonidet': [1654], 'P-40,': [1655], 'NaCl,': [1658, 1725, 2215, 2277], '1': [1659, 1726, 2066, 2219, 2246, 2281, 4769], 'EDTA).': [1661, 1728], 'Insoluble': [1662], 'particles': [1663], 'removed': [1665], 'centrifugation': [1667], '50,000': [1669], '×': [1670, 1784], 'g': [1671], '10': [1673, 1685], 'min.': [1674], 'Affinity': [1675], 'μl': [1686, 2181, 2190, 2247, 2269], 'immobilized': [1692], 'room': [1696], 'temperature': [1697], '4': [1699], 'h': [1700, 2306], 'gentle': [1702], 'shaking.': [1703], 'three': [1708, 1739, 2050, 2793, 2796, 4276, 4721, 5122], 'times': [1709, 1740, 2905], 'ETN': [1716], 'bound': [1730], 'eluted': [1733, 1826], 'washing': [1738, 2103], '0.1%': [1742, 2222], 'TFA.': [1743], 'isolated': [1745, 1870, 2980], 'dried': [1749], 'SpeedVac.': [1751], 'resulting': [1753, 2293, 2685, 2955, 3333], 'HPLC': [1759, 1794, 1810, 2903, 3023, 3059, 4105, 4309], '(0.1%': [1762, 1813], 'water,': [1766], 'v/v),': [1767], 'desalted': [1768], 'loaded': [1773], 'onto': [1774], 'in-house': [1776], 'packed': [1777], 'reverse-phase': [1778], 'column': [1780], '(360': [1781], 'μm': [1782, 1786], 'OD': [1783], '75': [1785], 'ID)': [1787], 'connected': [1788], 'Eksigent': [1791], 'NanoLC-1D': [1792], 'plus': [1793], 'system': [1795], '(Eksigent': [1796], 'Technologies).': [1797], 'Peptide': [1798], 'samples': [1799], 'analyzed': [1801, 1964, 2689, 2697, 2959, 3349, 3654], '2-hr': [1804], 'HPLC-gradient': [1805], '90%': [1809], 'B': [1812], 'acetonitrile)': [1817], 'flow': [1820], 'rate': [1821], '200': [1823, 2200], 'nL/min.': [1824], 'ionized': [1829], 'introduced': [1831], 'into': [1832, 3081], 'LTQ': [1834], 'Velos': [1835], 'Orbitrap': [1836, 1854, 1934], 'spectrometer': [1838], 'nanospray': [1841], 'source.': [1842], 'Survey': [1843], 'full-scan': [1844], 'spectra': [1846, 1962, 2132, 2695, 2764, 3440, 3478, 3670], '(from': [1847], 'm/z': [1848, 1861, 2126, 2141, 4119, 4323], '350–2000)': [1849], 'acquired': [1851, 1960, 2119, 2134], 'resolution': [1856, 2121, 2137], 'r': [1857, 2122], '=': [1858, 2123, 2225, 2290, 2847, 2859], '30,000': [1859, 2124], '400.': [1862], 'twenty': [1864], 'intense': [1866, 3890], 'ions': [1867, 1922, 1979, 3667], 'sequentially': [1869], 'linear': [1873], 'ion': [1874, 1941, 3488], 'trap': [1875, 1942, 3489], 'subjected': [1877, 2098, 3337], 'collision-activated': [1879], 'dissociation': [1880], 'normalized': [1883], 'energy': [1884, 3289, 4651, 5385, 5547], '35%.': [1886], 'exclusion': [1888, 1904], 'duration': [1889], 'data-dependant': [1892], 'scan': [1893, 1933, 1939, 1947], '36': [1895], 's,': [1896], 'repeat': [1898], 'count': [1899], 'window': [1905], 'set': [1907, 1956, 1981, 1989, 2331], '+2': [1909], 'Da': [1910, 1984, 3038, 3473, 3578, 4113, 4300, 4317], '−1': [1912], 'Da.': [1913, 1992, 2812], 'Charge': [1914], 'state': [1915], 'screening': [1916, 2397, 2879], 'enabled': [1918], 'singly': [1920], 'charged': [1921, 4123, 4327, 4614], 'excluded': [1924], 'fragmentation.': [1926], 'AGC': [1927], 'settings': [1928], '1E6': [1930], 'full': [1932], 'analysis,': [1935, 2874, 3591], '1E4': [1936], 'MSn': [1938, 1946], '6E4': [1944], 'Orbitrap.': [1949, 2144], 'Signal': [1950], 'threshold': [1951], 'CID': [1953, 2130], 'acquisition': [1954], '5000.': [1958], 'MS/MS': [1961, 1987, 2131, 2424, 2694, 2763, 2899, 2975, 2989, 3061, 3439, 3477, 3655, 3669], 'Mascot': [1966, 2059, 2844, 2856], 'sequence': [1967, 2700, 2745, 3354], 'alignment': [1968, 2701, 3355], 'algorithm': [1969], '(version': [1970, 2000, 2017], '2.1,': [1971], 'Matrix': [1972], 'Science,': [1973], '9).': [1974], 'Mass': [1975, 3494, 3589, 3601], 'tolerances': [1976], 'precursor': [1978], '0.01': [1983, 2286], '±0.5': [1991], 'Peak': [1993], 'lists': [1994], 'generated': [1996, 2433, 2693], 'extract_msn.exe': [1998], 'software': [1999], '5.0,': [2001], 'Thermo': [2002], 'Scientific).': [2003], 'All': [2004, 2055, 2761, 2850], 'data': [2006], 'searched': [2008], 'against': [2009, 2444, 5302, 5327, 5355], 'International': [2011], 'Index': [2013], 'database': [2016, 2028], '3.70,': [2018], '87069': [2019], 'sequences)': [2020], 'NCBI': [2022], 'RefSeq': [2023], 'E.': [2024, 2509, 2680, 2799, 4855, 4916, 5260], 'coli': [2025, 2510, 2681, 2800], 'k12': [2026], '(4123': [2029], 'sequences).': [2030], 'Cysteine': [2031], 'alkylation': [2032], 'methionine': [2035], 'oxidation,': [2036, 5285], '(lysine': [2040, 5454], '+86.00039': [2041], 'Da)': [2042], 'specified': [2044], 'variable': [2046], 'modifications.': [2047], 'Maximum': [2048], 'missing': [2051], 'cleavages': [2052], 'specified.': [2054], 'score': [2060, 2846, 2858], '30': [2062], 'E-value': [2064], 'below': [2065], 'manually': [2068, 2842, 2854], 'verified': [2069], 'peptide-spectrum': [2073], 'match': [2074], 'quality': [2075], 'satisfy': [2077], 'characteristic': [2078], 'neutral-loss': [2079], '(–44Da)': [2080], 'fragmentation': [2081, 3537], 'pattern.': [2082], 'peptide,': [2086, 2538, 3041, 4091, 4294], 'counterpart,': [2089], 'their': [2091, 3064, 4644], 'nano-HPLC/MS/MS': [2100], 'analysis.': [2101, 2908, 3553], 'Extensive': [2102], 'avoid': [2108], 'before': [2112], 'injection.': [2115], 'Full-MS': [2116], 'scans': [2117], '400,': [2127], 'targeted': [2129], '7500': [2139], '400': [2142], 'amounts': [2146], 'adjusted': [2151], 'so': [2152], 'intensities': [2155], 'only': [2162, 3994, 4738], 'within': [2163], 'few-fold': [2165], 'difference': [2166], 'counterpart.': [2170, 2970], 'final': [2177], 'volume': [2178], '50': [2180], 'per': [2182], 'well': [2183, 2297], '96-well': [2186], 'microplate.': [2187], 'Boc-Lys(Mal)-AMC': [2192], 'Boc-Lys(Succ)-AMC': [2194], 'stocking': [2195, 2251], '(10': [2197], 'mm)': [2198, 2254], 'ng': [2201], '(1∼11)': [2203], 'reaction': [2208, 2259, 2262, 4057, 4152, 4156, 4175, 4246, 4357, 4361, 4416, 4600], '(25': [2210, 2253, 2273], '130': [2213], '3.0': [2216, 2278, 3371], 'KCl,': [2218, 2280], 'MgCl2,': [2221, 2283], 'PEG8000,': [2223], '2': [2233, 2240, 2305, 5322], 'For': [2235, 3448, 5236], 'Sirtuins,': [2239], 'NAD+': [2250, 4177, 4228, 4376], 'stopped': [2265], '25': [2268, 2782], 'Tris-Cl,130': [2275], '30%': [2284, 2816], 'isopropanol,': [2285], 'mg/ml': [2287], 'trypsin,': [2288], '8.0).': [2291], 'solvent': [2294], 'mixed': [2296], 'another': [2304, 5393], 'time.': [2309], 'fluorescence': [2311, 2316, 3891], 'measured': [2313], 'on': [2314, 2503, 3444, 4572, 4584, 4707, 5460], 'plate': [2317], 'reader': [2318], '(The': [2319], 'Wallac': [2320], '1420': [2321], 'Work': [2322], 'station,': [2323], 'IET': [2324], 'Ltd,': [2325], 'Vernon': [2326], 'Hills,': [2327], 'IL)': [2328], 'excitation': [2330], '355': [2333], 'nm': [2334], 'emission': [2336], 'measure': [2337, 3833], '460': [2339], 'nm.': [2340], 'recently': [2342], 'PTM.': [2351, 2935], 'Ksucc': [2352, 2399, 4280], 'conserved,': [2357], 'When': [2392, 2554, 3652], 'proteomic': [2396], 'affinity': [2402, 3339, 3629], 'enrichment': [2403, 3340], 'anti-Ksucc': [2406], 'antibody,': [2407, 2436, 3344], 'HPLC/MS/MS,': [2408], 'sequence-alignment,': [2411], 'possible': [2415, 2705, 5442, 5473], 'presence': [2416, 4129, 4333], 'malonylated': [2419, 2460, 2822, 3737, 4253], 'low-quality': [2423], 'spectrum.': [2425], 'directly': [2427], 'test': [2428, 2489, 3230, 3824], 'malonylation.': [2446, 3047, 3377, 5532], 'Anti-Kmal': [2447], 'antigen': [2451], '(CEGGGGKmalGGSG)': [2453], 'library': [2456, 2543], 'fixed': [2459, 2468, 2546], 'lysine(Kmal)': [2461], 'but': [2462, 2533, 4189, 4383, 4410, 4580], 'not': [2463, 2534, 2567, 3804, 3928, 4147, 4190, 4352, 4384, 4794, 5037, 5065, 5091], 'libraries': [2465], 'K,': [2470], 'acetylated': [2471, 4168, 4740], 'lysine,': [2472, 2474], 'butyrylated': [2473], '(Ksucc),': [2477], 'glycine-rich': [2480], 'K': [2485], 'whether': [2490], 'exists': [2492], 'cells,': [2494, 4521], 'whole': [2505], 'lysates': [2507], 'Multiple': [2514], 'bands': [2515, 2559], 'could': [2519, 3413], 'efficiently': [2521], 'competed': [2522], 'away': [2523], 'antigen,': [2526], 'BSA,': [2540], '2B,': [2550], 'supplemental': [2551, 3072], 'Fig.': [2552, 3759, 4039, 4171, 4256, 4408, 4423, 4548], 'S1).': [2553], 'exposed': [2555], 'longer,': [2556], 'weaker': [2558], '(data': [2566], 'shown).': [2568], 'suggest': [2571, 2882, 5349, 5387], 'potential': [2586], 'sites': [2591, 3624], 'method': [2597, 2925], 'experiment,': [2662, 4509], 'enrich': [2668], 'digest': [2674], 'whole-cell': [2677, 2682, 3253, 3324], 'lysate.': [2683], 'HPLC/MS/MS.': [2691, 4686], 'peptides.': [2707], 'careful': [2709], 'manual': [2710, 2737], 'ensure': [2715], 'correct': [2716], '(10Chen': [2725], 'Kwon': [2727], 'S.W.': [2728], 'Kim': [2729, 4829], 'An': [2733], 'integrated': [2734], 'approach': [2735], 'searching': [2743], 'databases': [2746], 'spectra.J.': [2750], 'Proteome': [2751], 'Res.': [2752], '998-1005Crossref': [2755], '(161)': [2758], 'Information': [2769], '(supplementary': [2770], 'Data': [2771, 3397], 'Set': [2772, 3398], 'S1,': [2773], 'S2).': [2774], 'study': [2776, 3379], 'led': [2777, 3380], '17': [2785], '(Table': [2787], 'I)': [2788], '(supplemental': [2801, 3758, 4038, 4170, 4255, 4407, 4422, 4547], 'Table': [2802, 2943], 'S1)': [2803], 'contains': [2806], 'shift': [2809, 3035, 3373], '86.00': [2811], 'And': [2813, 4629], 'up': [2814], 'cells.Table': [2825], 'IList': [2826], 'cellProteinMascot': [2837], 'scoreaAll': [2838], 'verified;': [2843, 2855], 'cut-off': [2845, 2857], '30.Peptide': [2848], 'sequencem/zzGAPDH47TVDGPSGKLWR651.32702+46GALQNIIPASTGAAKAVGK927.01132+SLC25A553YKQIFLGGVDK677.35732+58YFPTQALNFAFKDK888.43592+57DFLAGGVAAAISKTAVAPIER1072.07562+36LAADVGKAGAER622.31762+NSUN259VINTGIKVWCR716.37672+ACTA139DSYVGDEAQSKR720.81502+PGK138FHVEEEGKGK623.29042+ENO151IEEELGSKAK595.29952+41TAIGKAGYTDK605.80172+MDH237NLGIGKVSSFEEK747.37612+DBI47AKWDAWNELK673.82352+GPI51ELQAAGKSPEDLER814.89272+HSPA983QATKDAGQISGLNVLR878.96202+ALDOA56ALQASALKAWGGK698.87292+51VDKGVVPLAGTNGETTTQGLDGLSER900.78223+HSPD145ISKGANPVEIR635.34322+TUT135AFNQGKIFK569.79792+HSPE171GKGGEIQPVSVK642.84382+51SQGKVLQATVVAVGSGSK901.48642+49VLQATVVAVGSGSKGK793.94562+HSP90AB146EMLQQSKILK652.35082+EPRS52AYVDDTPAEQMKAER905.40152+KRT843TLNNKFASFIDK742.37572+a': [2849], '30.': [2860], 'Open': [2861], 'table': [2862], 'tab': [2866], 'HPLC/MS/MS': [2881, 2907, 2961, 3351, 3552], 'existence': [2884, 5097], 'Identical': [2893], 'exhibit': [2896], 'same': [2898, 2902, 2988, 4164], 'patterns': [2900], 'retention': [2904], 'Accordingly,': [2909], 'built': [2916], 'best': [2924], 'validate': [2927], 'natural': [2930], 'bears': [2932], 'verify': [2937], 'I,': [2944], 'randomly': [2946], 'selected': [2947], 'five': [2948, 4059], 'synthesis.': [2953], 'pair-wise': [2958], 'between': [2962, 5480], 'spectrum': [2976, 2990], 'enolase': [2984], '(TAIGK+85.9988DaAGYTDK)': [2985], 'has': [2986, 4136, 4341, 4569, 4581, 5007, 5083], 'malonyl': [2999, 3293, 3422, 3866, 4139], '(TAIGKmalAGYTDK),': [3001], '3A).': [3010], 'co-elutes': [3017], '3B).': [3025], 'lines': [3028], 'evidence': [3030], '85.9988': [3037], 'TAIGK+85.9988DaAGYTDK,': [3042], 'caused': [3044, 3535, 3701, 5246], 'Likewise,': [3048, 3554, 4235, 4388], 'four': [3056, 4251], '(Figs.': [3068], '3C,': [3069], '3D,': [3070], 'Figs.': [3073], 'S2–S4).': [3074], 'Acetate': [3075], 'succinate': [3077], 'converted': [3080, 3285, 3407], 'acetyl': [3082], 'CoA': [3083, 5463], 'succinyl': [3085, 4344], 'CoA,': [3086, 3294], 'respectively': [3101], '11Allis': [3133], 'C.D.': [3134], 'Chicoine': [3135], 'L.G.': [3136], 'Richman': [3137], 'Schulman': [3139], 'I.G.': [3140], 'Deposition-related': [3141], 'micronuclei': [3145], 'conjugating': [3147], 'Tetrahymena.Proc.': [3148], 'Natl.': [3149, 5335], 'Acad.': [3150, 5336], 'Sci.': [3151, 5337], 'U.S.A.': [3152, 5338], '1985;': [3153], '82:': [3154], '8048-8052Crossref': [3155], '(104)': [3158], 'argue': [3162], 'may': [3165, 3432, 3817, 4793, 5391, 5445, 5536], 'similar': [3173], 'fashion': [3174], 'malonyl-CoA': [3176, 5176, 5185, 5205, 5231, 5383, 5406, 5413], 'synthetase': [3177, 4768], 'reported': [3179, 4657, 4790, 4899], '(12Mitzen': [3181], 'E.J.': [3182, 3209], 'Koeppen': [3183], 'A.H.': [3184, 3205], 'Malonate,': [3185], 'malonyl-coenzyme': [3186], 'A,': [3187], 'acetyl-coenzyme': [3189], 'developing': [3192], 'rat': [3193, 3217], 'brain.J.': [3194], 'Neurochem.': [3195], '1984;': [3196], '43:': [3197], '499-506Crossref': [3198], '(22)': [3201], '13Koeppen': [3204], 'Papandrea': [3206], 'J.D.': [3207], 'Mitzen': [3208], 'Fatty': [3210], 'biosynthesis': [3212], 'Wallerian': [3214], 'degeneration': [3215], 'sciatic': [3218], 'nerve.Muscle': [3219], 'Nerve.': [3220], '1979;': [3221], '369-375Crossref': [3223], '(17)': [3226], 'possibility,': [3232], 'fed': [3235], '20': [3239, 3310], 'Lysine': [3245, 4687], 'evaluated': [3250], 'our': [3260], 'antibody.': [3262], 'enhanced': [3270], 'treatment': [3272, 5210, 5367], '4A).': [3277], 'further': [3279, 4042, 4259, 5003], 'examine': [3280, 4075, 4260, 4426], 'if': [3281], 'molecule': [3290], 'malonylation,': [3304], 'labeled': [3306, 3361, 3388], '3-13C]-malonate': [3316], 'extracted': [3321], 'trypsin.': [3331, 3879], 'identification.': [3358], 'isotopically': [3360], 'Da-mass': [3372], 'Kmal-peptides': [3385], '3-13C]-malonyl': [3392], '4B': [3394], 'S3).': [3399], 'implied': [3402], 'activated': [3410], 'intermediate,': [3411], 'donor': [3423], 'reaction.': [3427, 4081, 4234], 'unique': [3435, 3762], 'signature': [3437, 3764], 'dependent': [3443], 'structure.': [3447], 'phosphopeptide': [3451], 'site': [3455, 3877], 'serine': [3459, 3632], 'threonine': [3461, 3634], 'residue': [3462, 3677], 'tends': [3463], 'lose': [3465], 'phosphate': [3467, 3541, 4767], 'group,': [3468], 'leading': [3469, 3567], '–98': [3472], 'satellite': [3474, 3570, 3680], 'peak': [3475, 3571, 3681, 4106, 4310], '(14DeGnore': [3479], 'J.P.': [3480], 'Qin': [3481], 'Fragmentation': [3483], 'phosphopeptides': [3485, 3515], 'spectrometer.J.': [3491], 'Am.': [3492], 'Soc.': [3493], 'Spectrom.': [3495, 3602], '9:': [3497], '1175-1188Crossref': [3498], '(235)': [3501], '15Carr': [3504], 'Huddleston': [3506], 'M.J.': [3507, 3620, 5201], 'Annan': [3508], 'R.S.': [3509, 4826], 'Selective': [3510], 'sequencing': [3513], 'femtomole': [3518], 'level': [3519], 'spectrometry.Anal.': [3522], 'Biochem.': [3523], '1996;': [3524], '239:': [3525], '180-192Crossref': [3526], '(330)': [3529], 'fragile': [3540], 'bond': [3542], 'ionization': [3546], 'source': [3547], 'analyzer': [3550], 'during': [3551], 'O-GlcNAc': [3556, 3626], 'very': [3560, 4028, 5415], 'lost': [3562, 4137, 4342], 'spectrometer,': [3566], 'neutral': [3574], 'loss': [3575, 3685, 3693, 4110, 4116, 4314, 4320], '203': [3577], '(16Darula': [3579], 'Chalkley': [3581], 'R.J.': [3582], 'Baker': [3583], 'P.': [3584, 5317], 'Burlingame': [3585], 'A.L.': [3586], 'Medzihradszky': [3587], 'K.F.': [3588], 'spectrometric': [3590], 'automated': [3592], 'complete': [3595], 'annotation': [3596], 'O-linked': [3598], 'glycopeptides.Eur.': [3599], '2010;': [3603], '16:': [3604], '421-428Crossref': [3605], '(38)': [3608], '17Wells': [3611], 'Vosseller': [3613], 'K.': [3614], 'Cole': [3615], 'R.N.': [3616], 'Cronshaw': [3617], 'Matunis': [3619], 'Hart': [3621], 'G.W.': [3622], 'tags': [3630], 'modifications.Mol.': [3636], 'Proteomics.': [3638], '2002;': [3639], '1:': [3640], '791-804Abstract': [3641], '(374)': [3649], 'found': [3660], 'fragment': [3666], '44': [3687], 'Da,': [3688], 'corresponds': [3690], 'CO2.': [3695], 'believe': [3697], 'thermal': [3703], 'decarboxylation,': [3704], 'process': [3706, 5163], 'readily': [3708], 'among': [3710], 'derivatives': [3711], 'malonic': [3713, 5238], '(18Brown,': [3715], 'W.': [3716, 5315], 'H.,': [3717], 'Foote,': [3718], 'S.,': [3720], 'Iverson,': [3721], 'B.': [3722, 4857], 'L.,': [3723], '(2009)': [3724], 'Organic': [3725], 'Chemistry.': [3726], '5th': [3727], 'edn,': [3728], '(Brooks/cole': [3729], 'Cengage': [3730], 'Learning)Google': [3731], 'During': [3733], 'reaction,': [3735, 4370], 'side': [3739, 4615], 'chain': [3740, 4616], 'forms': [3742], 'enol': [3744], 'intermediate': [3745, 5108, 5423], 'cyclic': [3748], 'transition': [3749], 'state,': [3750], 'quickly': [3752], 'tautomerizes': [3753], 'carbonyl': [3756], 'S5).': [3760], 'confirming': [3769], 'site.': [3777], 'tightly': [3785], 'groups': [3789], 'enzymes': [3791, 5477, 5523], 'opposing': [3793], 'enzymatic': [3794, 4045], 'activities,': [3795, 3811, 4015, 5087], 'acetyltransferases': [3797], '(KATs)': [3798], 'deacetylases': [3801], '(HDACs).': [3802], 'Because': [3803], 'hypothesize': [3813], 'some': [3815, 5033, 5436, 5475], 'involved': [3819], 'demalonylation.': [3822], 'hypothesis,': [3826], 'developed': [3828], 'fluorescence-based': [3830], 'HDACs.': [3841, 3856], 'HDAC-mimic': [3847], '18': [3855, 3904, 4962], 'HDAC': [3858, 3907, 3946, 3995, 4187, 4714, 4964], 'would': [3863], 'remove': [3864], 'creating': [3873], 'After': [3880], 'subsequent': [3882], 'digestion,': [3884], 'demalonylated': [3885, 4144], 'generate': [3888], 'signal.': [3892], 'Using': [3893, 4550], 'tested': [3897], '(including': [3906], '1–11': [3908], 'Sirtuin': [3910], '1–7).': [3911], 'exhibits': [3917, 3997], 'significant': [3918, 3930, 4570], 'activity,': [3921], 'did': [3927], '5A).': [3934], 'Detection': [3935], 'motivated': [3942], 'us': [3943], 'evaluate': [3945], 'family': [3947, 4715], "member's": [3948], 'toward': [3950, 4020], 'succinylation,': [3952, 4579], 'discovered': [3957], 'Interestingly,': [3989], 'strong': [3998], '5B).': [4006], 'contrast': [4008], 'negligible': [4018], 'deacetylation': [4022, 4032, 4415], 'different': [4029, 5416, 5479], 'HDAC1∼3,': [4035], '6,': [4036], 'Sirt1∼3': [4037], 'S7).': [4040], 'confirm': [4043], 'vitro,': [4050, 4267], '(DSYVGDEAQSKmalR,': [4065], 'IEEELGSKmalAK,': [4066], 'TAIGKmalAGYTDK,': [4067], 'AFNQGKmalIFK,': [4068, 4092], 'AYVDDTPAEQMKmalAER).': [4069], 'products': [4078], 'weight': [4087, 4290], 'TUT1': [4094], '905.4039Da': [4096], '6A).': [4098, 4211], 'Upon': [4099, 4303], 'incubation': [4100, 4304], '∼86': [4112], '(with': [4114, 4318], '–43': [4118], 'doubly': [4122, 4326], 'ion)': [4124, 4328], 'NAD+,': [4131, 4335], 'group.': [4140, 4345], 'contrast,': [4142, 4347, 4878], 'mock': [4151, 4356], 'S8A).': [4172], 'requires': [4176, 4375], 'inhibited': [4181, 4380], '(a': [4184], 'inhibitor),': [4188], '(TSA,': [4193], 'inhibitor': [4195, 4203], 'I/II': [4198], 'HDACs)': [4199], '(an': [4202], 'yeast': [4205], 'Sir2': [4206, 4859, 4919], 'Sirt1)': [4209], 'indicates': [4214], 'cofactor': [4231], 'show': [4238, 4881, 5281], 'S9).': [4257], '(VLLPEYGGTKsuccVVLDDK,': [4282], 'SQGKsuccVLQATVV,': [4283], 'ETGVDLTKsuccDNMALQR).': [4284], 'VLLPEYGGTKsuccVVLDDK,': [4295], 'HSPE1': [4297], '1845.9879': [4299], '6B).': [4302], '∼100': [4316], '–50': [4322], 'desuccinylated': [4349], 'enzyme-dead': [4365], 'mutant.': [4366], 'nicotinamide,': [4382], 'TSA': [4385], 'sirtinol.': [4387], 'S10),': [4409], 'cannot': [4411], 'acetyled': [4420], 'S11).': [4424], 'mitochondrial': [4440, 4807, 4864, 4883, 4893, 5196], 'gel': [4445, 4452], 'PVDF': [4455, 4465], '7A).': [4468], 'experiment': [4471], 'levels': [4479], 'decreased': [4481, 4541], 'bands.': [4485], 'indicated': [4488], 'corroborate': [4502], 'examined': [4511], 'HepG2': [4520], 'overexpressed': [4526], 'knockdown': [4528], 'siRNA.': [4530], 'response': [4543, 5399], 'S12).': [4549], 'livers': [4555, 4994], 'derived': [4556], 'mouse': [4560, 4993, 4998], 'knockout': [4563, 4815], 'mouse,': [4564], 'impact': [4571], 'global': [4574, 4863], 'little': [4582], 'influence': [4583], '7B).': [4588], 'reproducibly': [4592], 'Lysine,': [4610], 'positive': [4613], 'pH,': [4619], 'plays': [4620], 'folding.': [4628], 'methylation': [4631], 'studied': [4638], 'past': [4641], 'decade,': [4642], 'revealing': [4643], 'roles': [4646, 5381], 'transcriptional': [4648], 'metabolism.': [4652, 5114], 'study,': [4655, 4943], 'screening,': [4679], 'combination': [4684], 'dramatic': [4691], 'structural': [4692], 'changes': [4693, 5403], 'expected': [4703], 'impacts': [4706], 'consists': [4716], 'seven': [4718], 'sirtuins': [4719], '(Sirt1–7),': [4720], 'which,': [4723], 'Sirt3,': [4724], 'Sirt4,': [4725], 'located': [4732], 'mitochondrion.': [4734], 'CPS1': [4735], 'Sirt5-lysine': [4739], 'date.': [4744], 'deacetylate': [4749], 'increase': [4753], '(19Nakagawa': [4756], 'Lomb': [4758], 'D.J.': [4759], 'Haigis': [4760, 4845], 'M.C.': [4761], 'Guarente': [4762, 4847], 'SIRT5': [4764, 4814], 'Deacetylates': [4765], 'carbamoyl': [4766], 'regulates': [4771, 4862], 'urea': [4773], 'cycle.Cell.': [4774], '2009;': [4775], '137:': [4776], '560-570Abstract': [4777], '(614)': [4785], 'It': [4788, 5440, 5470], 'mitochondria': [4800], 'reasons.': [4803], 'First,': [4804], 'no': [4805], 'hyperacetylation': [4808], 'SIRT4': [4812], 'mice': [4816, 4880, 5280, 5324], '(20Lombard': [4817], 'D.B.': [4818], 'Alt': [4819], 'F.W.': [4820], 'H.L.': [4822], 'Bunkenborg': [4823], 'Streeper': [4825], 'Mostoslavsky': [4827], 'Yancopoulos': [4831], 'G.': [4832], 'Valenzuela': [4833], 'D.': [4834], 'Murphy': [4835], 'A.': [4836], 'Hirschey': [4841], 'M.D.': [4842, 5203], 'Bronson': [4843], 'R.T.': [4844], 'L.P.': [4848], 'Farese': [4849], 'Jr,': [4850], 'R.V.': [4851], 'Weissman': [4852], 'Schwer': [4856], 'Mammalian': [4858], 'homolog': [4860], 'SIRT3': [4861], 'acetylation.Mol.': [4866], '27:': [4870], '8807-8814Crossref': [4871], '(985)': [4874], 'SIRT3-knockout': [4879], 'striking': [4882], 'hyperacetylation,': [4885], 'indicating': [4886], 'deacetylase.': [4894], 'Second,': [4895], 'weak': [4902], '(21North': [4907], 'B.J.': [4908], 'Marshall': [4909], 'B.L.': [4910], 'Borra': [4911], 'M.T.': [4912], 'Denu': [4913], 'ortholog,': [4920], 'SIRT2,': [4921], 'NAD+-dependent': [4924], 'tubulin': [4925], 'deacetylase.Mol.': [4926], '2003;': [4928, 5339], '11:': [4929], '437-444Abstract': [4930], '(1251)': [4938], 'robust': [4946], 'Sirt5.': [4952], 'fluorometric': [4959], 'assays': [4960], 'transfection': [4990], 'wild-type': [4997], 'Sirt5-knockout': [5000], 'mouse.': [5001], 'much': [5008], 'higher': [5009], 'Eighteen': [5026], 'annotated': [5029], 'literature,': [5032], 'do': [5036, 5064], 'acetyllysine': [5040, 5068], 'HDACs,': [5060], 'On': [5070], 'hand,': [5073], 'although': [5074], 'does': [5090], 'exclude': [5092], 'Malonyl-CoA': [5104, 5115, 5152], 'routes:': [5124], '(1)': [5125], 'carboxylation': [5127, 5138], 'acetyl-CoA': [5129, 5140, 5174], 'catalyzed': [5130, 5141, 5164], 'acetyl-Coenzyme': [5132], 'carboxylase': [5134, 5321, 5363], '(ACC),': [5135], '(2)': [5136], 'propionyl-CoA': [5143], 'carboxylase,': [5144], '(3)': [5146], 'β-oxidation': [5147], 'old-chain-length': [5149], 'dicarboxylic': [5150], 'acids.': [5151, 5439], 'disposed': [5155], 'fatty': [5159, 5166, 5283, 5433], 'synthesis,': [5161, 5428], 'synthase': [5168], 'conversation': [5171], 'back': [5172], 'decarboxylase.': [5177], 'addition': [5179], 'being': [5181], 'metabolite,': [5184], 'function,': [5192], 'e.g.': [5193], 'inhibition': [5194, 5364], 'carnitine': [5197], 'palmitoyltransferase': [5198], '(CPT1)': [5199], '(22Wolfgang': [5200], 'Lane': [5202], 'Hypothalamic': [5204], 'CPT1c': [5207], 'obesity.FEBS': [5212], '278:': [5215], '552-558Crossref': [5216], '(51)': [5219], 'metabolite': [5225], 'molecule,': [5228], 'dysregulation': [5229], 'homeostasis': [5232, 5386], 'affects': [5233], 'aciduria,': [5239], 'inborn': [5241], 'error': [5242], 'metabolism': [5244], 'deficient': [5248, 5279], 'MCD': [5249], '(23MacPhee': [5251], 'G.B.': [5252], 'Logan': [5253], 'R.W.': [5254], 'Mitchell': [5255], 'J.S.': [5256], 'Howells': [5257], 'D.W.': [5258], 'Tsotsis': [5259], 'Thorburn': [5261], 'D.R.': [5262], 'Malonyl': [5263], 'coenzyme': [5264], 'decarboxylase': [5266], 'deficiency.Arch.': [5267], 'Dis.': [5268], 'Child.': [5269], '1993;': [5270], '69:': [5271], '433-436Crossref': [5272], '(34)': [5275], 'ACC2': [5278, 5350], 'increased': [5282], 'body': [5287, 5291], 'fat': [5288], 'weight,': [5292], 'despite': [5293], 'consuming': [5294], 'food': [5296], '(hyperphagia).': [5297], 'diabetes': [5303, 5330, 5358], 'obesity': [5305, 5328, 5356], 'induced': [5306, 5331], 'fat/high': [5309], 'carbohydrate': [5310], 'diets': [5311], '(24Abu-Elheiga': [5312], 'Oh': [5314], 'Kordari': [5316], 'Wakil': [5318], 'S.J.': [5319], 'Acetyl-CoA': [5320, 5362], 'high-fat/high-carbohydrate': [5333], 'diets.Proc.': [5334], '100:': [5340], '10207-10212Crossref': [5341], '(328)': [5344], 'observations': [5348], 'attractive': [5352], 'therapeutic': [5353], 'agents': [5354], '(25Harwood': [5359], 'H.J.': [5361], 'metabolic': [5369, 5417, 5422], 'syndrome.Curr.': [5370], 'Investig.': [5372], 'Drugs.': [5373], '2004;': [5374], '5:': [5375], '283-289PubMed': [5376], 'provide': [5392, 5537], 'layer': [5394], 'concentration.': [5407], 'Although': [5408], 'structurally': [5409], 'similar,': [5410], 'succinyl-CoA': [5411], 'pathways.': [5418], 'Succinyl-CoA': [5419], 'TCA': [5425], 'cycle,': [5426], 'porphyrin': [5427], 'catabolism': [5430], 'odd-chain': [5432], 'acids': [5434], 'branched-chain': [5437], 'use': [5446], 'malonylation),': [5458], 'depending': [5459], 'available': [5462], 'metabolites,': [5464], 'reprogram': [5466], 'networks.': [5469], 'pathways,': [5484], 'case': [5488], 'methylation.': [5494], 'likely': [5510], 'step': [5515], 'exciting': [5518], 'search': [5519], 'biological': [5528], 'Therefore,': [5533], 'paradigm': [5540], 'metabolism,': [5548], 'organisms.': [5551], 'Download': [5552], '.pdf': [5553], '(2.68': [5554], 'MB)': [5555], 'Help': [5556], 'pdf': [5558], 'files': [5559]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2162002416', 'counts_by_year': [{'year': 2024, 'cited_by_count': 44}, {'year': 2023, 'cited_by_count': 46}, {'year': 2022, 'cited_by_count': 61}, {'year': 2021, 'cited_by_count': 63}, {'year': 2020, 'cited_by_count': 53}, {'year': 2019, 'cited_by_count': 42}, {'year': 2018, 'cited_by_count': 64}, {'year': 2017, 'cited_by_count': 46}, {'year': 2016, 'cited_by_count': 68}, {'year': 2015, 'cited_by_count': 48}, {'year': 2014, 'cited_by_count': 47}, {'year': 2013, 'cited_by_count': 48}, {'year': 2012, 'cited_by_count': 37}], 'updated_date': '2025-01-09T00:50:00.240088', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
