Publication Information

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277, 290, 314, 341, 420, 463, 914, 1183, 1885, 2023, 2390, 2569, 2576, 2592, 2903, 2916, 2969, 3026, 3049, 3109, 3245, 3264, 3379, 3410, 3438, 3486, 3517, 3545, 3696, 3860, 3898, 3924, 3998], 'proliferation': [38, 51, 75, 181, 188, 224, 278, 291, 315, 421, 428, 464, 554, 846, 978, 1016, 1094, 1140, 1982, 2391, 2553, 3027, 3050, 3110, 3246, 3360, 3380, 3439, 3487, 3518, 3697], '(>20-fold': [39, 279], 'at': [40, 77, 280, 317, 2343, 2374, 2452, 2503, 3017, 3086, 3112, 3151, 3247, 3267, 3293, 3337, 3559, 3612, 3675, 3682, 3734, 3901, 4064, 4090, 4102, 4117, 4135, 4176, 4188, 4205, 4217, 4232, 4244, 4259, 4271, 4288, 4303, 4315], '15': [41, 78, 105, 281, 318, 345, 3268, 3294, 3326, 3407, 3430, 3462, 3735, 3740, 3785, 3800, 3824, 3903, 3957, 4035, 4043, 4335], 'mm': [42, 62, 79, 106, 282, 302, 319, 346, 2322, 2508, 2690, 2719, 2728, 2732, 2736, 2740, 3012, 3019, 3061, 3156, 3162, 3212, 3249, 3269, 3295, 3327, 3339, 3587, 3617, 3736, 3741, 3786, 3801, 3825, 3958], 'glucose).': [43, 63, 283, 303], 'Insulin-like': [44, 284], 'factor': [46, 286, 750, 760, 891, 1489, 1584], 'I': [47, 287, 892], '(IGF-I)-induced': [48, 288], 'glucose-dependent': [53, 293], 'only': [54, 294, 3136, 3344, 3702, 3716], 'in': [55, 170, 232, 295, 410, 472, 535, 582, 904, 976, 985, 1180, 1269, 1278, 1566, 1670, 1882, 2000, 2100, 2105, 2307, 2314, 2455, 2475, 2498, 2531, 2656, 2678, 2709, 3000, 3003, 3024, 3052, 3066, 3121, 3177, 3201, 3219, 3224, 3262, 3274, 3362, 3413, 3498, 3519, 3556, 3577, 3654, 3728, 3754, 3781, 3807, 3812, 3837, 3893, 3907, 3916, 3962, 3980, 3995, 4028, 4328], 'physiologically': [57, 297, 2107, 3054, 3152, 3203, 3535], 'relevant': [58, 298, 2108, 3055, 3153, 3204, 3536], 'concentration': [59, 160, 174, 299, 400, 414, 2110, 3045, 3101, 3635, 3653], 'range': [60, 175, 300, 415, 2111, 3046, 3056, 3205], 'The': [64, 216, 304, 456, 2133, 2244, 2278, 2458, 2487, 2519, 2585, 2640, 2704, 2957, 3547, 3657, 3767], 'combination': [65, 305, 3822], 'of': [66, 113, 137, 207, 214, 219, 306, 353, 377, 447, 454, 459, 523, 530, 533, 589, 681, 734, 780, 901, 911, 1010, 1017, 1142, 1271, 1283, 1360, 1372, 1445, 1481, 1570, 1674, 1752, 1756, 1764, 1776, 1867, 1879, 2002, 2013, 2102, 2168, 2273, 2378, 2385, 2482, 2523, 2535, 2543, 2550, 2649, 2664, 2712, 2717, 2755, 2830, 2901, 2914, 2959, 2980, 2996, 3069, 3124, 3180, 3197, 3227, 3243, 3277, 3309, 3342, 3365, 3392, 3418, 3459, 3524, 3534, 3538, 3549, 3570, 3636, 3659, 3714, 3719, 3769, 3778, 3815, 3823, 3840, 3855, 3896, 3911, 3919, 3984, 4015, 4019, 4344], 'IGF-I': [67, 103, 124, 169, 220, 307, 343, 364, 409, 460, 1064, 1137, 1169, 1263, 1759, 2232, 2513, 2695, 2964, 3135, 3164, 3198, 3214, 3230, 3257, 3280, 3310, 3343, 3368, 3375, 3419, 3441, 3483, 3525, 3541, 3551, 3571, 3593, 3639, 3646, 3652, 3664, 3761, 3765, 3791, 3830, 3843, 3912, 3985], 'synergistic,': [71, 311], 'increasing': [72, 158, 312, 398, 3550, 3581], '>50-fold': [76, 316], '+': [81, 321, 3329, 4046], '10': [82, 322, 2693, 2735, 2742, 2745, 3330, 3613, 3637, 3644, 3789, 3828, 4047, 4338], 'nm': [83, 323, 2694, 3331, 3596, 3614, 3638, 3645, 3790, 3829, 4339], 'IGF-I.': [84, 324], 'Glucose': [85, 122, 131, 325, 362, 371, 579, 2983], 'metabolism': [86, 326, 637, 3383], 'phosphatidylinositol': [88, 328, 768, 1361], '3′-kinase': [89, 117, 209, 329, 357, 449, 1362], '(PI': [90, 330, 1363], '3′-kinase)': [91, 331, 1364], 'activation': [92, 213, 332, 453, 733, 1270, 1371, 1444, 1673, 1775, 1866], 'were': [93, 189, 333, 429, 2181, 2205, 2237, 2248, 2261, 2272, 2312, 2372, 2440, 2490, 2562, 2607, 2642, 2675, 2706, 2943, 3757, 4323], 'necessary': [94, 334], 'for': [95, 335, 634, 655, 662, 1877, 2449, 2472, 2493, 2696, 2910, 3482, 3540, 3663, 3693, 3993, 4325], 'both': [96, 336], 'IGF-I-stimulated': [99, 339, 3694], 'proliferation.': [102, 151, 342, 391, 2076, 2982, 3546], 'tyrosine': [109, 349, 1174, 1274, 1280, 1479, 1762, 2763], 'phosphorylation': [110, 350, 1175, 1480, 1672, 1763, 2764, 4021], 'mediated': [111, 190, 221, 351, 430, 461], 'recruitment': [112, 352], 'Grb2/mSOS': [114, 354], 'PI': [116, 208, 356, 448, 766, 1441], 'to': [118, 236, 358, 476, 897, 909, 1014, 1265, 1354, 1370, 1440, 1497, 1573, 1873, 1979, 2031, 2063, 2098, 2539, 2579, 2612, 2645, 3542, 3661, 3760, 3848, 4034, 4042], 'IRS-2': [119, 359, 2179], 'pp60.': [121, 361], 'also': [125, 365, 848, 1483, 1747, 3673], 'induced': [126, 366], 'Shc': [127, 367], 'association': [128, 368], 'with': [129, 148, 157, 178, 369, 388, 397, 418, 982, 2078, 2510, 3033, 3193, 3580, 3602, 3605, 3608], 'Grb2/mSOS.': [130, 370], '(3–18': [132, 372], 'IGF-I,': [135, 375, 757, 2997, 3615, 3715, 3744, 4340], 'glucose,': [138, 378, 3163, 3213, 3281, 3622], 'activated': [139, 156, 379, 396, 707], 'mitogen-activated': [140, 199, 380, 439, 736, 745], 'protein': [141, 200, 381, 440, 708, 737, 746, 752, 791, 1173, 1578, 1767, 2234, 2759, 2762, 2905, 3771, 3930, 4020, 4345], 'kinase': [142, 201, 382, 441, 709, 738, 792, 1275, 1449, 1662, 1666, 1667, 1761, 3772, 4051, 4077, 4123, 4192], 'but': [143, 202, 383, 442, 3016, 4009], 'this': [144, 384, 676, 2524, 2556, 3099, 3187, 3354, 3755, 4010], 'did': [145, 385, 3512, 3887], 'correlate': [147, 387], 'IGF-I-induced': [149, 186, 389, 426], 'contrast,': [153, 393], 'p70S6K': [154, 394, 1870], '(between': [161, 401], '6': [162, 402, 3058, 3211, 3248], '18': [164, 404, 2689, 3060, 3087, 3304, 3586, 3616], 'mm),': [165, 405, 3388, 3463, 3492], 'potentiated': [167, 407], 'by': [168, 198, 408, 438, 558, 851, 907, 1857, 2467, 2601, 2651, 2841, 2922, 2974, 3349, 3784, 3967, 4013], 'same': [172, 412], 'which': [176, 416, 635, 1585, 1769, 1858, 3236, 3287, 3493, 3699, 3928], 'correlated': [177, 417], 'rate.': [182, 422, 2554], 'Thus,': [183, 423, 3750], 'via': [191, 431, 679, 1062, 1109, 1167, 1365, 1493, 1758], 'a': [192, 432, 490, 536, 660, 731, 1089, 1110, 1580, 1875, 1880, 2061, 2083, 2106, 2161, 2494, 2567, 2646, 2776, 2934, 3021, 3105, 3138, 3216, 3259, 3389, 3479, 3609, 3634, 3703, 3725, 3804, 3832, 3859, 3923, 3990], 'signaling': [193, 227, 433, 467, 652], 'mechanism': [194, 434], 'facilitated': [197, 437], 'dependent': [203, 443], 'on': [204, 444, 1092, 1500, 2442, 2595, 2609, 2967, 3047, 3141, 3313, 3436, 3467, 3553, 3776, 4023], 'IRS-mediated': [205, 445], 'induction': [206, 446, 1878, 2001], 'activity': [210, 450, 1276, 3933], 'downstream': [212, 452, 1443], 'p70S6K.': [215, 455], 'dependence': [218, 458], 'emphasizes': [225, 465], 'mechanisms': [228, 468], 'are': [229, 469, 483, 593, 665, 1871, 2092, 2931], 'rather': [230, 470, 3190], 'unique': [231, 471], 'being': [233, 473], 'tightly': [234, 474], 'linked': [235, 475], 'glycolytic': [237, 477], 'metabolic': [238, 478, 2033], 'flux.': [239, 479], 'Adult': [480], 'β-cells': [482, 524, 534, 584, 903, 1019, 3500], 'relatively': [484, 2093], 'well': [485, 668, 2008, 2094], 'differentiated': [486, 1018, 2095], 'consequently': [488], 'low': [491], 'mitotic': [492, 2085], 'index': [493, 2086, 2979], '(1Brockenbrough': [494, 539], 'J.S.': [495, 540], 'Weir': [496, 541], 'G.C.': [497, 542], 'Bonner-Weir': [498, 543], 'S.': [499, 544, 609, 641, 826, 834, 930, 963, 1023], 'Diabetes.': [500, 545, 625, 697, 1074, 4002], '1988;': [501, 546], '37:': [502, 547], '232-236Crossref': [503, 548], 'PubMed': [504, 513, 549, 574, 603, 629, 690, 701, 725, 820, 839, 861, 922, 968, 999, 1078, 1103, 1160, 1199, 1231, 1242, 1258, 1317, 1328, 1344, 1389, 1421, 1432, 1475, 1516, 1548, 1559, 1606, 1638, 1649, 1708, 1719, 1739, 1792, 1824, 1835, 1851, 1901, 1933, 1944, 1960, 1989, 2045, 2128, 2197, 2300, 2366, 2418, 2433, 2635, 2804, 2871, 3400, 3507, 3882, 3952, 4006], 'Google': [505, 516, 550, 577, 606, 632, 693, 704, 728, 823, 842, 864, 877, 925, 944, 971, 1002, 1037, 1051, 1079, 1106, 1163, 1202, 1232, 1245, 1261, 1318, 1331, 1347, 1392, 1422, 1435, 1476, 1519, 1549, 1562, 1609, 1639, 1652, 1709, 1722, 1742, 1795, 1825, 1838, 1854, 1904, 1934, 1947, 1963, 1992, 2048, 2131, 2200, 2303, 2369, 2421, 2436, 2638, 2805, 2827, 2872, 2894, 3403, 3510, 3885, 3955, 4007], 'Scholar,': [506, 607, 616, 694, 824, 865, 926, 945, 1038, 1203, 1233, 1246, 1319, 1332, 1393, 1423, 1520, 1550, 1610, 1640, 1710, 1723, 1796, 1826, 1839, 1905, 1935, 1948, 2422, 2806, 2873], '2Swenne': [507], 'I.': [508, 569, 598, 618, 685, 856, 917, 1044, 1067, 1984], 'Diabetologia.': [509, 570, 599, 686, 857, 918, 1985, 3396, 3503], '1992;': [510, 571, 600, 613, 645, 687, 858, 919, 1986, 2125, 2297, 2363, 2632], '35:': [511, 572, 601, 688, 859, 920, 1987], '193-201Crossref': [512, 573, 602, 689, 860, 921, 1988], 'Scopus': [514, 575, 604, 630, 691, 702, 726, 821, 840, 862, 923, 942, 969, 1000, 1035, 1104, 1161, 1200, 1243, 1259, 1329, 1345, 1390, 1433, 1517, 1560, 1607, 1650, 1720, 1740, 1793, 1836, 1852, 1902, 1945, 1961, 1990, 2046, 2129, 2198, 2301, 2367, 2419, 2434, 2636, 2825, 2892, 3401, 3508, 3883, 3953], '(188)': [515, 576, 605, 692, 863, 924, 1991], 'Scholar).': [517, 551, 578, 648, 843, 878, 972, 1003, 1052, 1135, 1262, 1348, 1436, 1477, 1563, 1653, 1743, 1855, 1964, 2049, 2132, 2201, 2370, 2437, 2639, 2828, 2895], 'Under': [518], 'normal': [519], 'circumstances': [520], 'proportion': [522], 'undergoing': [525, 594], 'mitosis': [526], 'is': [527, 638, 979, 1005, 1083, 1351, 1864, 2028, 3494], 'about': [528, 2613], '0.5%': [529], 'population': [532, 592, 915], 'islet': [538, 583, 913], 'Nonetheless,': [552, 670], 'can': [555, 847, 1746], 'be': [556, 678, 849, 1874, 2018], 'several': [559, 852, 1970], 'nutrient': [560], 'factors,': [561], 'such': [562], 'as': [563, 2060, 2183, 2348, 2382, 2616, 2702, 2766, 2775, 2844, 2933, 2977, 3588, 3649], 'amino': [566], 'acids': [567], '(2Swenne': [568, 597, 684, 855, 916, 1983], 'increases': [580], 'mitogenesis': [581, 1881, 2004, 3999], 'so': [585, 3335], 'around': [587], '5%': [588, 2346], 'DNA': [595, 2386, 2544, 2593, 2970], 'synthesis': [596, 2387, 2545, 2971], '3Bonner-Weir': [608], 'Diabetes': [610, 642, 719, 872], 'Nutr.': [611, 643], 'Metab.': [612, 644, 720], '5:': [614, 646], '1-3Google': [615, 647], '4Swenne': [617], 'Bone': [619], 'A.J.': [620, 1071], 'Howell': [621], 'S.L.': [622], 'Hellerstrom': [623], 'C.': [624, 716, 801, 1040, 2399, 2424], '1980;': [626, 3397, 3504], '29:': [627], '686-692Crossref': [628], '(63)': [631], 'Scholar),': [633, 705, 729, 1080, 1164, 1993, 2304, 3404, 3511, 3886, 3956, 4008], 'required': [639, 3381], '(3Bonner-Weir': [640], 'However,': [649, 3040, 3915], 'intracellular': [651, 682, 1995], 'responsible': [654], 'glucose-mediated': [656, 706], 'proliferation,': [658], 'beyond': [659], 'requirement': [661, 1876, 3533], 'metabolism,': [664], 'particularly': [667], 'understood.': [669], 'has': [672, 1054], 'postulated': [674, 1056], 'may': [677, 2016], 'elevation': [680], 'cAMP': [683, 3926], '5Chick': [695], 'W.L.': [696], '1973;': [698], '22:': [699], '687-693Crossref': [700], '(87)': [703], 'C': [710, 4078], '(6Welsh': [711], 'M.': [712, 795, 803, 1147, 1151, 1186, 1190, 1376, 1380, 1503, 1507, 1593, 1597, 1779, 1783, 1888, 1892, 2113, 2165, 2285, 2351, 2393, 2401, 2620], 'Mares': [713], 'J.': [714, 809, 1129, 1153, 1192, 1227, 1313, 1382, 1417, 1463, 1466, 1509, 1544, 1599, 1634, 1704, 1728, 1785, 1820, 1894, 1929, 2407, 2428, 2792, 2795, 2816, 2859, 2862, 2883, 3877, 3947], 'Öberg': [715], 'Karlsson': [717], 'T.': [718, 1205, 1221, 1291, 1307, 1395, 1411, 1522, 1538, 1612, 1628, 1682, 1698, 1798, 1814, 1907, 1923], 'Rev.': [721, 1252, 1338, 1845, 1954, 2040, 2191], '1993;': [722], '9:': [723], '25-36Crossref': [724], '(27)': [727], 'and/or': [730], 'Ca2+-dependent': [732], '(MAPK)': [739], '1The': [740], 'abbreviations': [741], 'used': [742, 2055, 2306, 2381, 3648], 'are:': [743], 'MAPK,': [744], 'kinase;': [747, 756, 773], 'Grb-2,': [748], 'bound': [751], '2;': [753], 'MEK,': [754], 'MAP-kinase': [755], 'insulin-like': [758, 889], 'I;': [761], 'IRS,': [762, 1757], 'insulin': [763, 1285, 2103, 3660, 3685, 3720], 'receptor': [764, 1170, 1286, 1760], 'substrate;': [765], '3′-kinase,': [767], '3-kinase;': [769], 'p70S6K,': [770], '70-kDa': [771, 1447], 'S6': [772, 1448], 'Shc,': [774], 'SH2-containing': [775, 1766], 'protein;': [776, 782], 'mSOS,': [777], 'murine': [778, 1575], 'sons': [779], 'sevenless-1': [781], 'BSA,': [783, 4334], 'bovine': [784], 'serum': [785, 2468, 2483, 2652, 2665], 'albumin;': [786], 'GH,': [787], 'hormone;': [789], 'PKA,': [790], 'A.': [793, 835, 869, 949, 964, 4001], '(7Frodin': [794, 2392], 'Sekine': [796, 2394], 'N.': [797, 934, 947, 1027, 1096, 1128, 2395], 'Roche': [798, 2396], 'E.': [799, 808, 2397, 2406], 'Filloux': [800, 2398], 'Prentki': [802, 2400], 'Wollheim': [804, 2122, 2294, 2360, 2402, 2629], 'C.B.': [805, 2036, 2123, 2295, 2361, 2403, 2630], 'Van': [806, 2404], 'Obberghen': [807, 2405], 'Biol.': [810, 1130, 1156, 1195, 1385, 1467, 1512, 1602, 1729, 1788, 1897, 2408, 2796, 2821, 2863, 2888], 'Chem.': [811, 1131, 1468, 1730, 2409, 2797, 2864], '1995;': [812, 1731, 2042, 2410], '270:': [813, 1732, 2411], '7882-7889Abstract': [814, 2412], 'Full': [815, 817, 1472, 1734, 1736, 2413, 2415, 2801, 2868], 'Text': [816, 818, 1473, 1735, 1737, 2414, 2416, 2802, 2869], 'PDF': [819, 1474, 1738, 2417, 2803, 2870], '(199)': [822, 2420], '8Khoo': [825], 'Cobb': [827, 2166], 'M.H.': [828, 1725], 'Proc.': [829, 958], 'Natl.': [830, 959], 'Acad.': [831, 960], 'Sci.': [832, 961], 'U.': [833, 962], '1997;': [836, 1239, 1325, 1429, 1556, 1646, 1716, 1832, 1941, 4003], '94:': [837], '5599-5604Crossref': [838], '(136)': [841], 'Pancreatic': [844], 'stimulated': [850, 2831, 4025], '9Scharfmann': [866], 'R.': [867, 1209, 1295, 1399, 1526, 1616, 1686, 1802, 1911], 'Basmaciogullari': [868], 'Czernichow': [870], 'P.': [871, 951, 1122, 2117, 2289, 2355, 2624, 3871, 3941], 'Res.': [873], '1990;': [874, 965], '15:': [875], '137-141PubMed': [876], 'particular,': [880], 'somatolactogenic': [881], 'hormones': [882], '(prolactin': [883], 'hormone': [886], '(GH))': [887], '(IGF-I)': [893], 'shown': [896, 1978], 'increase': [898, 975, 984, 1980, 3023, 3031, 3173, 3218, 3261, 3515, 3576, 3611, 3727, 3806, 3834], 'number': [900], 'replicating': [902], 'rodent': [905], 'islets': [906], 'up': [908], '6%': [910], '10Nielsen': [927], 'J.H.': [928, 957, 1021, 1098, 1124, 1461, 2790, 2857], 'Linde': [929, 1022], 'Welinder': [931, 1024], 'B.S.': [932, 1025], 'Billestrup': [933, 1026, 1127], 'Madsen': [935, 1028], 'O.D.': [936, 1029], 'Mol.': [937, 1030, 2819, 2886], 'Endocrinol.': [938, 1031, 1099], '1989;': [939, 1032, 2430], '13:': [940, 1033], '165-173Crossref': [941, 1034], '(115)': [943, 1036], '11Billestrup': [946], 'Moldrup': [948], 'Serup': [950], 'Mathews': [952], 'L.S.': [953], 'Norstedt': [954], 'G.': [955], 'Nielsen': [956, 1097, 1123], '87:': [966], '7210-7214Crossref': [967], '(59)': [970], 'A': [973, 4052, 4158], 'prolactin-induced': [974], 'likely': [980, 1085], 'associated': [981], 'an': [983, 1567, 2383, 2548, 2978, 3574, 3650], 'mass': [987], 'observed': [988, 3007, 3029, 3120, 3589, 3850], 'during': [989], 'pregnancy': [990], '(12Brelje': [991], 'T.C.': [992, 1455, 2784, 2851], 'Sorenson': [993], 'R.L.': [994], 'Endocrinology.': [995, 2124, 2296, 2362, 2429, 2631], '1991;': [996, 1048, 1100], '128:': [997], '45-57Crossref': [998], '(121)': [1001], 'GH': [1004, 1058, 1087, 1143], 'perhaps': [1006], 'most': [1008, 1165, 1883, 3042], 'potent': [1009], 'peptide': [1011, 1971], 'induce': [1015], '(10Nielsen': [1020], '13Hellerström': [1039], 'Sjöholm': [1041], 'Å.': [1042], 'Swenne': [1043], 'Acta': [1045], 'Padiatr.': [1046], 'Scand.': [1047], '377:': [1049], '55-62Crossref': [1050], 'It': [1053, 3131], 'mediates': [1059, 1088], 'local': [1063], 'production': [1065], '(14Swenne': [1066], 'Hill': [1068], 'D.J.': [1069], 'Strain': [1070], 'Milner': [1072], 'R.D.G.': [1073], '1987;': [1075], '36:': [1076, 1256, 1342, 1849, 1958, 2195], '288-294Crossref': [1077], 'more': [1084], 'direct': [1090], 'effect': [1091, 2958, 3140, 3188, 3308, 3348, 3435, 3466, 3548, 3629, 3658, 3768, 4018], '(15Billestrup': [1095], '129:': [1101], '883-888Crossref': [1102], '(98)': [1105], 'Scholar)': [1107], 'probably': [1108, 1166], 'JAK2/STAT5': [1111], 'pathway': [1114, 1178, 1754, 1862, 2838], '(16Hansen': [1115], 'L.H.': [1116], 'Wang': [1117, 1456, 2785, 2813, 2852, 2880], 'X.': [1118], 'Kopchick': [1119], 'J.J.': [1120], 'Bouchelouche': [1121], 'Galsgaard': [1125], 'E.D.': [1126], '1996;': [1132, 1157, 1196, 1228, 1255, 1314, 1341, 1386, 1418, 1513, 1545, 1603, 1635, 1705, 1789, 1821, 1848, 1898, 1930, 1957, 2194], '271:': [1133], '12273-12669Google': [1134], 'Likewise,': [1136, 3448], 'stimulates': [1138], 'or': [1144, 2266, 2511, 2688, 3416, 3429, 3444, 3454, 3461, 3522, 3906], 'prolactin': [1145], '(17Benito': [1146, 1185, 1375, 1502, 1592, 1778, 1887], 'Valverde': [1148, 1187, 1377, 1504, 1594, 1780, 1889], 'A.M.': [1149, 1188, 1378, 1505, 1595, 1781, 1890], 'Lorenzo': [1150, 1189, 1379, 1506, 1596, 1782, 1891], 'Int.': [1152, 1191, 1381, 1508, 1598, 1784, 1893], 'Biochem.': [1154, 1193, 1383, 1510, 1600, 1786, 1895, 2041, 3878, 3948], 'Cell': [1155, 1194, 1384, 1511, 1601, 1787, 1896], '28:': [1158, 1197, 1387, 1514, 1604, 1790, 1899], '499-510Crossref': [1159, 1198, 1388, 1515, 1605, 1791, 1900], '(104)': [1162, 1201, 1391, 1518, 1608, 1794, 1903], 'subsequent': [1172], 'other': [1181, 2022, 2079, 2203, 2259], 'mammalian': [1182, 1884], 'types': [1184, 1886], '18Kadowaki': [1204, 1394, 1521, 1611, 1797, 1906], 'Tobe': [1206, 1292, 1396, 1523, 1613, 1683, 1799, 1908], 'K.': [1207, 1215, 1217, 1293, 1301, 1303, 1397, 1405, 1407, 1524, 1532, 1534, 1614, 1622, 1624, 1684, 1692, 1694, 1800, 1808, 1810, 1909, 1917, 1919], 'Honda-Yamamoto': [1208, 1294, 1398, 1525, 1615, 1685, 1801, 1910], 'Tamemoto': [1210, 1296, 1400, 1527, 1617, 1687, 1803, 1912], 'H.': [1211, 1297, 1401, 1528, 1618, 1688, 1804, 1913], 'Kaburagi': [1212, 1298, 1402, 1529, 1619, 1689, 1805, 1914], 'Y.': [1213, 1219, 1223, 1225, 1299, 1305, 1309, 1311, 1403, 1409, 1413, 1415, 1530, 1536, 1540, 1542, 1620, 1626, 1630, 1632, 1690, 1696, 1700, 1702, 1806, 1812, 1816, 1818, 1915, 1921, 1925, 1927], 'Momomura': [1214, 1300, 1404, 1531, 1621, 1691, 1807, 1916], 'Ueki': [1216, 1302, 1406, 1533, 1623, 1693, 1809, 1918], 'Takahashi': [1218, 1304, 1408, 1535, 1625, 1695, 1811, 1920], 'Yamauchi': [1220, 1306, 1410, 1537, 1627, 1697, 1813, 1922], 'Akanuma': [1222, 1308, 1412, 1539, 1629, 1699, 1815, 1924], 'Yazaki': [1224, 1310, 1414, 1541, 1631, 1701, 1817, 1926], 'Endocrin.': [1226, 1312, 1416, 1543, 1633, 1703, 1819, 1928], '43:': [1229, 1315, 1419, 1546, 1636, 1706, 1822, 1931], 'S33-S41Crossref': [1230, 1316, 1420, 1547, 1637, 1707, 1823, 1932], '19Yenush': [1234, 1320, 1424, 1551, 1641, 1711, 1827, 1936], 'L.': [1235, 1321, 1425, 1552, 1642, 1712, 1828, 1937, 2119, 2291, 2357, 2626, 2812, 2814, 2879, 2881], 'White': [1236, 1249, 1322, 1335, 1426, 1464, 1553, 1643, 1713, 1829, 1842, 1938, 1951, 2188, 2425, 2793, 2860], 'M.F.': [1237, 1250, 1323, 1336, 1427, 1465, 1554, 1644, 1714, 1830, 1843, 1939, 1952, 2189, 2426, 2794, 2861], 'Bioessays.': [1238, 1324, 1428, 1555, 1645, 1715, 1831, 1940], '19:': [1240, 1326, 1430, 1557, 1647, 1717, 1833, 1942], '491-500Crossref': [1241, 1327, 1431, 1558, 1648, 1718, 1834, 1943], '(253)': [1244, 1330, 1434, 1561, 1651, 1721, 1837, 1946], '20Myers': [1247, 1333, 1840, 1949], 'M.G.': [1248, 1334, 1453, 1841, 1950, 2187, 2782, 2849], 'Annu.': [1251, 1337, 1844, 1953, 2039, 2190], 'Pharmacol.': [1253, 1339, 1846, 1955, 2192], 'Toxicol.': [1254, 1340, 1847, 1956, 2193], '615-658Crossref': [1257, 1343, 1850, 1959, 2196], '(297)': [1260, 1346, 1853, 1962, 2199], 'binds': [1264, 1772], 'IGF-I-receptor': [1267], 'resulting': [1268, 1669, 1774], 'its': [1272, 1366, 1494, 2032], 'intrinsic': [1273], 'turn': [1279], 'phosphorylates': [1281, 1664], 'members': [1282], 'substrate': [1287], '(IRS)': [1288], 'family': [1289], '(18Kadowaki': [1290, 1681], 'Tyrosine-phosphorylated': [1349], 'IRS': [1350, 1482, 1501], 'then': [1352, 1438, 1657, 1770, 2491, 2643, 2676, 2707, 3700], 'able': [1353], 'recruit': [1355], '85-kDa': [1357], 'regulatory': [1358], 'subunit': [1359], 'SH2': [1367, 1495], 'domain,': [1368], 'leading': [1369], 'enzyme': [1374], 'This': [1437, 1564, 3628, 3988], 'leads': [1439], '3′-kinase-dependent': [1442], '(p70S6K)': [1450], '(21Myers': [1451, 2780, 2847], 'Jr.,': [1452, 2781, 2848], 'Grammer': [1454, 2783, 2850], 'L.M.': [1457, 2786, 2853], 'Sun': [1458, 2787, 2854], 'X.J.': [1459, 2788, 2855], 'Pierce': [1460, 2789, 2856], 'Blenis': [1462, 2791, 2815, 2858, 2882], '1994;': [1469, 2798, 2822, 2865, 2889, 3879, 3949], '269:': [1470, 2799, 2866], '28783-28789Abstract': [1471, 2800, 2867], 'IGF-I-mediated': [1478, 2068], 'engages': [1484], 'bridging': [1486], 'molecule': [1487], 'receptor-bound': [1490], 'protein-2': [1491], '(Grb-2)': [1492], 'domain': [1496], 'phosphotyrosine': [1498], 'site': [1499], 'results': [1565], 'binding': [1569], 'IRS-docked': [1571], 'Grb-2': [1572], 'Son-of-Sevenless': [1576], '1': [1577, 2321, 3018, 3161, 3595], '(mSOS),': [1579], 'guanine': [1581], 'nucleotide': [1582], 'exchange': [1583], 'converts': [1586], 'inactive': [1587], 'Ras-GDP': [1588], 'into': [1589, 2589, 2988, 3079, 3144, 3169, 3316, 3470, 3669, 3731], 'active': [1590], 'Ras-GTP': [1591], 'Activated': [1654], 'GTP-bound': [1655], 'Ras': [1656], 'recruits': [1658], 'Raf': [1660], 'serine': [1661], 'MAP': [1665], '(MEK),': [1668], 'MEK-mediated': [1671], 'MAPK': [1676, 1868], '(erk-1': [1677], '-2': [1679], 'isoforms)': [1680], '22Cobb': [1724], 'Goldsmith': [1726], 'E.J.': [1727], '14843-14846Abstract': [1733], '(1662)': [1741], 'Furthermore,': [1744], 'IGF': [1745], 'activate': [1748], 'Ras/MAPK': [1750, 1777], 'branch': [1751], '(Shc)': [1768], 'directly': [1771], 'Grb-2/mSOS': [1773], 'Notwithstanding,': [1856, 3104, 3353], 'ever': [1859], 'mediated,': [1865], 'known': [1872], 'β-cell,': [1968], 'although': [1969], 'nutrients': [1975], 'pathway(s)': [1998], 'involved': [1999], 'Moreover,': [2010], 'regulation': [2012], 'actually': [2017], 'uniquely': [2019], 'different': [2020, 2504], 'from': [2021, 2138, 2150, 2163, 2207, 2221, 2227, 2239, 2249, 2263, 4060, 4086, 4098, 4113, 4131, 4172, 4184, 4201, 4213, 4228, 4240, 4255, 4267, 4284, 4299, 4311], 'types,': [2024], 'since': [2025], 'function': [2027], 'exquisitely': [2029], 'related': [2030], 'state': [2034], '(23Newgard': [2035], 'McGarry': [2037], 'J.D.': [2038], '64:': [2043], '689-719Crossref': [2044], '(494)': [2047], 'these': [2051, 3797], 'studies': [2052], 'we': [2053], 'line': [2058], 'model': [2062], 'better': [2064], 'characterize': [2065], 'specially': [2073], 'influence': [2074], 'Compared': [2077], 'lines,': [2081], 'despite': [2082], 'higher': [2084, 3107, 3117, 3239, 3290, 3357], 'than': [2087, 3118, 3240, 3291, 3358], 'primary': [2088], 'β-cells,': [2089], 'cells': [2091, 2311, 2439, 2464, 2489, 2561, 2606, 2641, 2674, 2705, 2990, 3005, 3081, 3146, 3171, 3318, 3472, 3558, 3603, 3671, 3733, 3783, 3964], 'respond': [2097], 'terms': [2101], 'secretion': [2104], '(24Asfari': [2112, 2284, 2350, 2619], 'Janjic': [2114, 2286, 2352, 2621], 'D.': [2115, 2287, 2353, 2622, 3865, 3935], 'Meda': [2116, 2288, 2354, 2623], 'Guodong': [2118, 2290, 2356, 2625], 'Halban': [2120, 2292, 2358, 2627], 'P.A.': [2121, 2293, 2359, 2628], '130:': [2126, 2298, 2364, 2633], '167-178Crossref': [2127, 2299, 2365, 2634], '(748)': [2130, 2302, 2368, 2637], '[methyl-3H]thymidine': [2134], '(20': [2135, 4107], 'Ci/mmol)': [2136], 'NEN': [2139, 2228], 'Life': [2140, 2229, 2251], 'Science': [2141, 2230], 'Products': [2142], 'Inc.': [2143], '(Boston,': [2144], 'MA).': [2145], 'Anti-"active-MAPK"': [2146], 'antiserum': [2147, 2158], 'purchased': [2149, 2206, 2238, 2262], 'Promega': [2151], 'Corp.': [2152], '(Madison,': [2153], 'WI),': [2154], '"total': [2156], 'MAPK"': [2157], '(erk1/erk2)': [2159], 'gift': [2162], 'Dr.': [2164], '(University': [2167], 'Texas': [2169], 'Southwestern': [2170], 'Medical': [2171], 'Center,': [2172], 'Dallas,': [2173], 'TX),': [2174], 'IRS-1': [2177], 'antisera': [2180, 2204], 'generated': [2182], 'described': [2184, 2349, 2617, 2767, 2845], 'previously': [2185, 2618, 2846, 3590, 3851], '(20Myers': [2186], 'All': [2202, 2257], 'Upstate': [2208], 'Biotechnology': [2209], '(Lake': [2210], 'Placid,': [2211], 'NY).': [2212], 'Transblot': [2213], 'nitrocellulose': [2214], 'membrane': [2215], '(0.45': [2216], 'μm': [2217, 2326, 2743, 2750], 'pore': [2218], 'size)': [2219], 'Bio-Rad,': [2222], 'immunoblot': [2223, 2897], 'chemiluminescence': [2224, 2773], 'detection': [2225, 2778], 'kit': [2226], 'Products.': [2231], 'kinase/phosphatase': [2235], 'inhibitors': [2236, 3775, 4022, 4343], 'Calbiochem-Novabiochem': [2240], '(La': [2241, 2254], 'Jolla,': [2242, 2255], 'CA).': [2243, 2256], '(Rp)-2′-O-monobutyryl-cAMP': [2245, 4053], '(Sp)-2′-O-monobutyryl-cAMP': [2247, 3856, 4070], 'Biolog': [2250], 'Sciences': [2252], 'Institute': [2253], 'biochemicals': [2260], 'either': [2264, 3902], 'Sigma': [2265], 'Fisher': [2267], 'Scientific': [2268], '(Pittsburgh,': [2269], 'PA)': [2270], 'highest': [2275], 'purity': [2276], 'available.': [2277], 'experiments.': [2309, 3656], 'maintained': [2313], 'RPMI': [2315, 2476, 2499, 2657, 2680], '1640': [2316, 2477, 2658, 2681, 4330], 'medium': [2317, 2459, 2659, 2682, 4331], 'containing': [2318, 2478, 2660, 2683, 4332], '2': [2319, 2450, 2727], 'mml-glutamine,': [2320], 'sodium': [2323, 2729, 2733, 2737], 'pyruvate,': [2324], '50': [2325, 2718, 2731], 'β-mercaptoethanol,': [2327], '100': [2328, 2331, 2749], 'units/ml': [2329], 'penicillin,': [2330], 'μg/ml': [2332, 2746], 'streptomycin,': [2333], '10%': [2334], 'fetal': [2335], 'calf': [2336], 'serum,': [2337], '11.2': [2339], 'mmglucose,': [2340], 'incubated': [2342, 2448, 2492, 2677, 4324], '37': [2344, 2453], '°C,': [2345], 'CO2': [2347], 'Cells': [2371], 'subcultured': [2373, 2608], '80%': [2375], 'confluence.': [2376], 'Incorporation': [2377], '[3H]thymidine': [2379, 2538, 2586, 2975, 2986, 3001, 3077, 3142, 3167, 3220, 3265, 3314, 3411, 3468, 3554, 3578, 3598, 3667, 3729, 3779, 3808, 3899, 3960, 4026, 4031, 4039], 'indicator': [2384], '25Hofmann': [2423], 'Whittaker': [2427], '124:': [2431], '257-264Crossref': [2432], '(16)': [2435], 'cultured': [2441], '96-well': [2443], 'plates': [2444, 2611], '(105': [2445], 'cells/well)': [2446], 'days': [2451], '°C': [2454], 'medium.': [2457], 'removed': [2461], 'made': [2465], 'quiescent': [2466, 2671, 4320], 'deprivation': [2471, 2655], '24': [2473, 2496, 3113, 3338, 4326], 'h': [2474, 2497, 2522, 4327], '0.1%': [2479, 2501, 2661, 4333], 'BSA': [2480, 2502, 2662], 'instead': [2481, 2663], 'no': [2485, 2667, 2998, 3034, 3433, 3465], 'glucose.': [2486, 2668], 'further': [2495, 3530], '1640,': [2500], 'concentrations': [2506, 3154, 3458, 3537, 3552, 3562, 3678, 3686, 3718], '(0–24': [2507], 'glucose)': [2509], 'without': [2512, 3743], '(0.1–100': [2514], 'nm),': [2515], '±': [2516, 2692, 2936, 2963, 3788, 4056, 4068, 4073, 4075, 4082, 4094, 4109, 4121, 4127, 4139, 4144, 4146, 4153, 4155, 4161, 4163, 4168, 4180, 4197, 4209, 4224, 4236, 4251, 4263, 4278, 4280, 4295, 4307, 4337, 4341], 'various': [2517, 3560, 3676, 4342], 'inhibitors.': [2518], 'last': [2520], '4': [2521, 2739], 'latter': [2525], 'incubation': [2526, 2558], 'period': [2527, 2648], 'carried': [2529], 'out': [2530], 'additional': [2533, 3909, 3982], 'presence': [2534, 3415, 3521, 3910, 3918, 3983], '5': [2536, 2698], 'μCi/ml': [2537], 'monitor': [2540], 'degree': [2542], 'gain': [2547], 'assessment': [2549], 'After': [2555, 2669], 'final': [2557], 'period,': [2559, 2672], 'collected': [2563], 'lysed': [2565, 2708], 'using': [2566, 2769, 2945], 'semi-automatic': [2568], 'harvester': [2570], '(Cambridge': [2571], 'Technology': [2572], 'Inc.)': [2573], 'lysates': [2577], 'transferred': [2578], 'Whatmann': [2580], 'glass': [2581, 2596], 'fiber': [2582, 2597], 'micropore': [2583], 'filters.': [2584], 'specifically': [2587], 'incorporated': [2588], 'trapped': [2594], 'filters': [2598], 'counted': [2600], 'liquid': [2602], 'scintillation': [2603], 'counting.': [2604], '10-cm': [2610], '50%': [2614], 'confluence': [2615], 'subjected': [2644], '24-h': [2647], 'quiescence': [2650], 'fresh': [2679], '0,': [2684], '3,': [2685], '6,': [2686], '9,': [2687], 'between': [2697, 2834, 2941, 3008, 3057, 3583], '60': [2700], 'min': [2701], 'indicated.': [2703], '0.5': [2710, 3011], 'ml': [2711], 'ice-cold': [2713], 'lysis': [2714], 'buffer': [2715], 'consisting': [2716], 'Hepes': [2720], '(pH': [2721], '7.5),': [2722], '1%': [2723], '(v/v)': [2724], 'Nonidet': [2725], 'P-40,': [2726], 'vanadate,': [2730], 'fluoride,': [2734], 'pyrophosphate,': [2738], 'EDTA,': [2741], 'leupeptin,': [2744], 'aprotonin,': [2747], 'phenylmethylsulfonyl': [2751], 'fluoride.': [2752], 'Immunoblot': [2753], 'analysis': [2754, 2843], 'expression': [2760], 'previously,': [2768], 'horseradish': [2770], 'peroxidase': [2771], 'based': [2772], 'reaction': [2774], 'secondary': [2777], 'method': [2779, 2926], '26Cheatham': [2807, 2874], 'B.': [2808, 2875, 3875, 3945], 'Vlahos': [2809, 2876], 'C.J.': [2810, 2877], 'Cheatham': [2811, 2878], 'Kahn': [2817, 2884], 'C.R.': [2818, 2885], 'Cell.': [2820, 2887], '17:': [2823, 2890], '4902-4911Crossref': [2824, 2891], '(1001)': [2826, 2893], 'Examination': [2829], 'protein-protein': [2832], 'interactions': [2833], 'proteins': [2839], 'co-immunoprecipitation': [2842], 'For': [2896], 'analysis,': [2898], '50–75': [2899], 'μg': [2900, 2913], 'total': [2904, 2917], 'lysate': [2906], 'used,': [2908], 'immunoprecipitation': [2911], '750': [2912], 'protein.': [2918], 'Protein': [2919], 'assay': [2920], 'bicinchoninic': [2924], 'acid': [2925, 4150], '(Pierce,': [2927], 'Rockford,': [2928], 'IL).': [2929], 'Data': [2930], 'presented': [2932], 'mean': [2935], 'S.E.': [2937], 'Statistically': [2938], 'significant': [2939, 3691, 3891, 4058, 4084, 4096, 4111, 4129, 4170, 4182, 4199, 4211, 4226, 4238, 4253, 4265, 4282, 4297, 4309], 'differences': [2940], 'groups': [2942], 'analyzed': [2944], "Student's": [2946], 't': [2947], 'test,': [2948], 'where': [2949], 'p': [2950, 3071, 3091, 3282, 3623, 3745, 4065, 4091, 4103, 4118, 4136, 4177, 4189, 4206, 4218, 4233, 4245, 4260, 4272, 4289, 4304, 4316], '<': [2951, 3036, 3072, 3092, 3127, 3182, 3232, 3253, 3283, 3299, 3323, 3370, 3421, 3624, 3707, 3746, 3818, 3845, 3970], '0.05': [2952], 'considered': [2954], 'statistically': [2955], 'significant.': [2956], '(0.1–24': [2961], '(10': [2965, 3665, 4080, 4222, 4293], 'nm)': [2966], 'determined': [2973], 'incorporation': [2976, 2987, 3002, 3078, 3143, 3168, 3221, 3266, 3315, 3412, 3469, 3555, 3579, 3599, 3668, 3730, 3780, 3809, 3900, 3961, 4027, 4032, 4040], '(Fig.': [2991, 3014, 3102, 3351, 3384, 3446, 3473, 3488, 3526, 3565, 3591, 3640, 3679, 3852], '1).': [2992, 3039, 3075, 3103, 3130, 3159, 3209, 3256, 3302, 3352, 3373, 3592, 3853], 'absence': [2995, 3068, 3123, 3179, 3226, 3276, 3364, 3417, 3523, 3569, 3713, 3814, 3839], 'change': [2999], '0': [3009], '1),': [3015, 3095, 3185, 3235, 3286, 3334], 'modest': [3022, 3726], '(1.4-fold': [3030], 'compared': [3032, 3192, 3601, 4033, 4041], 'glucose,p': [3035], '0.001;': [3037, 3073, 3128, 3183, 3233, 3284, 3371, 3422, 3625, 3971], 'Fig.': [3038, 3074, 3094, 3129, 3158, 3184, 3208, 3234, 3255, 3285, 3301, 3333, 3372, 3423, 3626, 3709, 3748], 'effective': [3043], 'occurred': [3051, 3085], '(4–19-fold': [3063], 'above': [3064, 3082, 3098, 3174, 3222, 3272, 3325, 3594, 3620, 3633, 3739, 3810, 3835], 'glucose;': [3070, 3157], 'Maximum': [3076], '"zero': [3083], 'glucose"': [3084], 'mmglucose': [3088, 3114, 3305, 3904, 4336], '(19-fold': [3089], 'increase,': [3090], '0.0001;': [3093], 'declined': [3097], '14-fold': [3106], 'rate': [3111, 3242, 3361, 3895], 'significantly': [3116, 3320, 3514, 3978], '(p': [3126, 3231, 3252, 3298, 3322, 3369, 3420, 3706, 3817, 3844, 3969], 'apparent': [3133], 'exerted': [3137], 'notable': [3139], 'when': [3147], 'present': [3150, 3443], 'Below': [3160], 'modestly': [3165], '(1.9-fold': [3172], 'zero': [3175, 3621], 'IGF-I,p': [3181], 'small': [3191], 'synergistic': [3195, 3307], 'effects': [3196], 'mm;': [3207], 'At': [3210], 'instigated': [3215, 3258, 3484, 3803], '10-fold': [3217], '2.5-fold': [3238], 'alone': [3251, 3297, 3905], '0.01;': [3254, 3300], 'maximum': [3260], '(52-fold': [3271], '4.2-fold': [3289], 'Above': [3303], 'diminished': [3321], '0.001': [3324], 'IGF-I;': [3332], 'addition': [3341, 4014], 'surpassed': [3345], '1.4-fold': [3350], '21-fold': [3356], 'Both': [3374], 'glucose-stimulated': [3377], '2).': [3385, 3424, 3447, 3489, 3527], 'Mannoheptulose': [3386], '(15': [3387, 3491], 'competitive': [3390], 'inhibitor': [3391], 'glycolysis': [3393], '(27Ashcroft': [3394, 3501], 'S.J.H.': [3395, 3502], '18:': [3398, 3505], '5-15Crossref': [3399, 3506], '(214)': [3402, 3509], 'completely': [3405], 'inhibited': [3406, 3966], 'mmglucose-stimulated': [3408], 'Not': [3425], 'surprisingly,': [3426], 'mannoheptulose': [3427], '(3': [3428], 'had': [3432, 3464], 'independent': [3434], 'whether': [3440], 'non-metabolizable': [3450], 'analogues,': [3452], '2-deoxyglucose': [3453], '3-O-methyl': [3455], '(at': [3457], '3': [3460, 3584], '2),': [3474], 'could': [3476, 3723], 'provide': [3478], 'suitable': [3480], 'platform': [3481], 'Fructose': [3490], 'efficiently': [3496], 'metabolized': [3497], 'These': [3528], 'observations': [3529, 3752], 'emphasize': [3531], 'examined': [3564, 3674, 3793], '3).': [3566, 3627], 'there': [3572], 'incremental': [3575], '>2-fold': [3600], 'treated': [3604], 'alone,': [3607], 'maximal': [3610], '(49-fold': [3619], 'exceeded': [3632], '3),': [3641], 'subsequently': [3643], 'optimal': [3651], 'following': [3655], 'compete': [3662], 'nm)-stimulated': [3666], '4).': [3680, 3710, 3749], 'Only': [3681], 'very': [3683], 'high': [3684, 3717], '(>10': [3687, 3721], 'μm)': [3688, 3722], 'any': [3690, 3890], 'competition': [3692], 'observed,': [3698], 'rendered': [3701], '20–30%': [3704], 'inhibition': [3705], '0.02;': [3708], 'instigate': [3724], '(1.3-fold': [3738], '0.05;': [3747], 'study': [3756], 'predominately': [3758], 'attributable': [3759], 'working': [3762], 'through': [3763], 'receptor.': [3766], 'specific': [3770], 'phosphatase': [3774, 4148], 'stimulation': [3777], '(Table': [3794, 3913, 3986], 'I).': [3795, 3914, 3987], 'series': [3798], 'experiments': [3799], '20-fold': [3805], '0.001),': [3819], 'gave': [3831], '52-fold': [3833], '0.001)': [3846], 'similar': [3847], 'Addition': [3854], '(5': [3857, 3921, 4054, 4071, 4159, 4249], 'μm),': [3858, 3922], 'permeable': [3861, 3925], 'PKA': [3862, 3994], 'agonist': [3863], '(28Ogreid': [3864, 3934], 'Dostmann': [3866, 3936], 'W.': [3867, 3937], 'Genieser': [3868, 3938], 'H.G.': [3869, 3939], 'Niemann': [3870, 3940], 'Doskeland': [3872, 3942], 'S.O.': [3873, 3943], 'Jastorff': [3874, 3944], 'Eur.': [3876, 3946], '221:': [3880, 3950], '1089-1094Crossref': [3881, 3951], '(15)': [3884, 3954], 'show': [3889], 'changes': [3892], '(Rp)-O2′-monobutyryl-cAMP': [3920], 'analogue': [3927], 'inhibits': [3929], 'kinase-A': [3931], '(PKA)': [3932], 'glucose-induced': [3959, 3996], '87%': [3968], 'Table': [3972], 'I),': [3973], 'whereas': [3974], 'affected': [3979], 'suggested': [3989], 'possible': [3991], 'role': [3992], '(29Sjoholm': [4000], '46:': [4004], '1141-1147Crossref': [4005], 'overcome': [4012], 'IGF-I.Table': [4016], 'IThe': [4017], 'glucose/IGF-I': [4024], 'cellsInhibitorPercentage': [4030], 'mM': [4036, 4044], 'controlPercentage': [4038], 'nM': [4048], 'IGF-1': [4049], 'controlProtein': [4050], 'μm)6.3': [4055], '0.7aStatistically': [4057], 'difference': [4059, 4085, 4097, 4112, 4130, 4171, 4183, 4200, 4212, 4227, 4239, 4254, 4266, 4283, 4298, 4310], 'equivalent': [4062, 4088, 4100, 4115, 4133, 4174, 4186, 4203, 4215, 4230, 4242, 4257, 4269, 4286, 4301, 4313], 'control': [4063, 4089, 4101, 4116, 4134, 4175, 4187, 4204, 4216, 4231, 4243, 4258, 4270, 4287, 4302, 4314], '≤': [4066, 4092, 4104, 4119, 4137, 4178, 4190, 4207, 4219, 4234, 4246, 4261, 4273, 4290, 4305, 4317], '0.02.94.2': [4067], '4.9': [4069], 'μm)78.7': [4072], '8.488.6': [4074], '11.3Protein': [4076], 'Sphingosine': [4079], 'μm)37.7': [4081], '4.6aStatistically': [4083], '0.02.42.9': [4093], '3.5aStatistically': [4095], '0.02.': [4105, 4220, 4247, 4274, 4291], 'Staurosporin': [4106], 'nm)48.8': [4108], '3.1aStatistically': [4110], '0.02.81.1': [4120], '2.8Ca2+/calmodulin': [4122], 'Calmidozolium': [4124], '(50': [4125, 4151, 4276], 'nm)20.9': [4126], '1.8aStatistically': [4128, 4308], '0.02.81.4': [4138], '3.7': [4140], 'KN-93': [4141], '(1': [4142], 'μm)91.0': [4143], '3.794.4': [4145], '4.3Phosphoprotein': [4147], 'Okadaic': [4149], 'nm)76.5': [4152], '5.097.6': [4154], '8.4': [4156], 'Cyclosporin': [4157], 'μm)88.6': [4160], '8.1101.8': [4162], '1.1': [4164], 'Orthovanadate': [4165], '(0.5': [4166], 'mm)3.3': [4167], '0.2aStatistically': [4169, 4181, 4252], '0.02.2.5': [4179], '0.02.Tyrosine': [4191], 'cascades': [4193], 'Genistein': [4194], '(25': [4195], 'μm)5.7': [4196], '0.6aStatistically': [4198], '0.02.4.7': [4208], '0.8aStatistically': [4210], 'Wortmannin': [4221], 'nm)1.9': [4223], '0.4aStatistically': [4225], '0.02.3.6': [4235], '1.0aStatistically': [4237], 'LY294002': [4248], 'μm)1.6': [4250], '0.02.5.4': [4262], '0.5aStatistically': [4264], 'PD98059': [4275], 'μm)82.6': [4277], '6.416.5': [4279], '1.9aStatistically': [4281], 'Rapamycin': [4292], 'nm)50.5': [4294], '3.8aStatistically': [4296], '0.02.45.6': [4306], '0.02.Approximately': [4318], '105': [4319], 'cells/well': [4322], 'RPM1': [4329], 'kinases,': [4346], 'phosphoprotein': [4347], 'phosphatases,': [4348]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2161783089', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2025-01-12T04:18:05.799052', 'created_date': '2016-06-24'}