Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2161154988', 'doi': 'https://doi.org/10.1196/annals.1345.016', 'title': 'Ferritin as an Iron Concentrator and Chelator Target', 'display_name': 'Ferritin as an Iron Concentrator and Chelator Target', 'publication_year': 2005, 'publication_date': '2005-11-01', 'ids': {'openalex': 'https://openalex.org/W2161154988', 'doi': 'https://doi.org/10.1196/annals.1345.016', 'mag': '2161154988', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16339659'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1196/annals.1345.016', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S8802318', 'display_name': 'Annals of the New York Academy of Sciences', 'issn_l': '0077-8923', 'issn': ['0077-8923', '1749-6632'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5063149850', 'display_name': 'Xiaofeng Liu', 'orcid': 'https://orcid.org/0000-0002-0447-5658'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'XIAOFENG LIU', 'raw_affiliation_strings': ["CeBIC (Center for BioIron at CHORI, The Children's Hospital Oakland Research Institute), Oakland, California 94609, USA"], 'affiliations': [{'raw_affiliation_string': "CeBIC (Center for BioIron at CHORI, The Children's Hospital Oakland Research Institute), Oakland, California 94609, USA", 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112774522', 'display_name': 'Elizabeth C. Theil', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'ELIZABETH C. THEIL', 'raw_affiliation_strings': ["CeBIC (Center for BioIron at CHORI, The Children's Hospital Oakland Research Institute), Oakland, California 94609, USA", 'Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, California 94720, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, California 94720, USA', 'institution_ids': ['https://openalex.org/I95457486']}, {'raw_affiliation_string': "CeBIC (Center for BioIron at CHORI, The Children's Hospital Oakland Research Institute), Oakland, California 94609, USA", 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5112774522'], 'corresponding_institution_ids': ['https://openalex.org/I95457486'], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.38, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.43083, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '1054', 'issue': '1', 'first_page': '136', 'last_page': '140'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10452', 'display_name': 'Iron Metabolism and Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10452', 'display_name': 'Iron Metabolism and Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10554', 'display_name': 'Hemoglobinopathies and Related Disorders', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10915', 'display_name': 'Trace Elements in Health', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778319317', 'wikidata': 'https://www.wikidata.org/wiki/Q22327449', 'display_name': 'Ferritin', 'level': 2, 'score': 0.88624024}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.59960693}, {'id': 'https://openalex.org/C2777799968', 'wikidata': 'https://www.wikidata.org/wiki/Q185137', 'display_name': 'Thalassemia', 'level': 2, 'score': 0.5334473}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4871616}, {'id': 'https://openalex.org/C2776590208', 'wikidata': 'https://www.wikidata.org/wiki/Q2025687', 'display_name': 'Hemochromatosis', 'level': 2, 'score': 0.47806978}, {'id': 'https://openalex.org/C197404232', 'wikidata': 'https://www.wikidata.org/wiki/Q319827', 'display_name': 'Chelation', 'level': 2, 'score': 0.46084073}, {'id': 'https://openalex.org/C2777417653', 'wikidata': 'https://www.wikidata.org/wiki/Q1313081', 'display_name': 'Iron deficiency', 'level': 3, 'score': 0.43527105}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.4152846}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3403368}, {'id': 'https://openalex.org/C2778248108', 'wikidata': 'https://www.wikidata.org/wiki/Q5445', 'display_name': 'Anemia', 'level': 2, 'score': 0.32143608}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22860709}, {'id': 'https://openalex.org/C179104552', 'wikidata': 'https://www.wikidata.org/wiki/Q11165', 'display_name': 'Inorganic chemistry', 'level': 1, 'score': 0.16123086}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.12333444}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.10914463}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.09332761}], 'mesh': [{'descriptor_ui': 'D005293', 'descriptor_name': 'Ferritins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D007501', 'descriptor_name': 'Iron', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007502', 'descriptor_name': 'Iron Chelating Agents', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001692', 'descriptor_name': 'Biological Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005293', 'descriptor_name': 'Ferritins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005293', 'descriptor_name': 'Ferritins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007501', 'descriptor_name': 'Iron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007502', 'descriptor_name': 'Iron Chelating Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019266', 'descriptor_name': 'Iron, Dietary', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D019266', 'descriptor_name': 'Iron, Dietary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013789', 'descriptor_name': 'Thalassemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013789', 'descriptor_name': 'Thalassemia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013789', 'descriptor_name': 'Thalassemia', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1196/annals.1345.016', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S8802318', 'display_name': 'Annals of the New York Academy of Sciences', 'issn_l': '0077-8923', 'issn': ['0077-8923', '1749-6632'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16339659', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/2', 'display_name': 'Zero hunger', 'score': 0.5}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 16, 'referenced_works': ['https://openalex.org/W1774187086', 'https://openalex.org/W1975197163', 'https://openalex.org/W1983419175', 'https://openalex.org/W1988842623', 'https://openalex.org/W2006383772', 'https://openalex.org/W2010675241', 'https://openalex.org/W2014723793', 'https://openalex.org/W2015197751', 'https://openalex.org/W2090148249', 'https://openalex.org/W2098123600', 'https://openalex.org/W2103995951', 'https://openalex.org/W2106699885', 'https://openalex.org/W2112841789', 'https://openalex.org/W2138551389', 'https://openalex.org/W2143284406', 'https://openalex.org/W2146033714'], 'related_works': ['https://openalex.org/W4249202226', 'https://openalex.org/W3139366364', 'https://openalex.org/W3108548843', 'https://openalex.org/W2475412998', 'https://openalex.org/W2405665699', 'https://openalex.org/W2341016428', 'https://openalex.org/W2104475379', 'https://openalex.org/W2003046281', 'https://openalex.org/W1995248905', 'https://openalex.org/W1586454276'], 'abstract_inverted_index': {'A': [0], 'bstract': [1], ':': [2], 'Ferritin': [3], 'has': [4, 91], 'a': [5, 33, 125, 158, 167, 199], 'broad': [6], 'role': [7, 169], 'to': [8, 26, 51, 57, 66, 94, 98, 112, 119, 150, 213], 'play': [9], 'in': [10, 46, 84, 115, 153, 172], 'new': [11, 34, 168, 180], 'strategies': [12], 'for': [13, 103], 'managing': [14], "Cooley's": [15], 'anemia': [16], 'and': [17, 53, 73, 142, 207], 'the': [18, 82, 131, 143, 148, 154, 163, 187], 'thalassemias.': [19], 'Serum': [20], 'ferritin': [21, 37, 85, 137, 164, 171, 197, 214], 'iron': [22, 30, 55, 83, 121, 127, 132, 149, 160, 175], 'content': [23], 'is': [24, 138, 156, 177], 'relegated': [25], 'reporting': [27], 'on': [28, 183], 'tissue': [29], 'concentrations.': [31], 'Recently,': [32], 'property': [35, 135], 'of': [36, 48, 76, 136, 147, 170, 186, 190, 195, 203, 210], 'was': [38], 'discovered:': [39], 'gated': [40], 'pores,': [41], 'which': [42], 'are': [43, 192], 'highly': [44], 'conserved': [45], 'ferritins': [47], 'humans': [49], 'down': [50], 'bacteria,': [52], 'control': [54, 218], 'flow': [56], 'chelators.': [58], 'The': [59], 'pore': [60, 133], 'gates': [61], 'can': [62], 'be': [63, 95, 113, 151], 'selectively': [64], 'opened': [65], 'increase': [67], 'chelator': [68, 219], 'access': [69], 'by': [70], 'mutation,': [71], 'temperature,': [72], 'physiological': [74], 'concentrations': [75], 'urea.': [77], 'In': [78], 'another': [79], 'recent': [80, 184], 'observation,': [81], 'from': [86, 157], 'seeds': [87], 'such': [88, 105], 'as': [89, 106, 198], 'soybeans': [90], 'been': [92], 'shown': [93], 'readily': [96], 'available': [97], 'tissues': [99], 'with': [100], 'high': [101], 'demand': [102], 'iron,': [104, 206], 'red': [107], 'blood': [108], 'cells,': [109], 'but': [110], 'slower': [111], 'mobilized': [114], 'other': [116], 'tissues,': [117], 'compared': [118], 'nonheme': [120, 205], 'salts,': [122], 'presumably': [123], 'through': [124], 'controlled': [126], 'gating': [128, 134], 'mechanism.': [129], 'Because': [130], 'more': [139], 'thoroughly': [140], 'investigated,': [141], 'knowledge': [144, 185], 'that': [145, 217], 'much': [146], 'chelated': [152], 'thalassemias': [155], 'solid': [159], 'mineral': [161], 'inside': [162], 'protein': [165, 215], 'nanocage,': [166], 'regulating': [173], 'cellular': [174], 'homeostasis': [176], 'established.': [178], 'Two': [179], 'areas,': [181], 'based': [182], 'molecular': [188], 'properties': [189], 'ferritin,': [191], '(1)': [193], 'exploration': [194], 'food': [196], 'potentially': [200], 'safer': [201], 'form': [202], 'dietary': [204], '(2)': [208], 'development': [209], 'chelators': [211], 'targeted': [212], 'pores': [216], 'access.': [220]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2161154988', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-08T03:58:01.438827', 'created_date': '2016-06-24'}