Publication Information

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1851], '(in': [156], 'mg/dL):': [157], 'glucose': [158, 205, 513, 716, 867, 921, 942, 986, 1080, 1151, 1180, 1225, 1229, 1231, 1377], '102,': [159], 'triglycerides': [160, 2323], '(TG)': [161], '238,': [162], 'low-density': [163], 'lipoprotein': [164, 170, 2353], 'cholesterol': [165, 171, 411, 516, 2235, 2249, 2327, 2354], '(LDL-C)': [166], '147,': [167], 'high-density': [169, 2352, 2377], '(HDL-C)': [172], '52.E.C.': [173], 'hypertensive': [175, 588, 650, 1925], 'hypertriglyceridemic': [177], 'at': [179, 570, 700, 744, 1516, 1690], 'increased': [180, 571, 666, 702, 746, 1488, 1882], 'risk': [181, 224, 282, 291, 393, 547, 619, 667, 747, 1534, 1664, 1897, 2064, 2332, 2356, 2380, 2579, 3095, 3226], 'CHD.': [183, 669], 'Less': [184], 'obvious': [185], 'these': [188, 338, 564, 1596, 1679], 'abnormalities': [190, 235, 300, 637, 728, 1345, 1400, 1542, 1571, 1579, 1632, 1739, 1874, 2055, 2124], 'are': [191, 397, 560, 566, 710, 931, 935, 1012, 1038, 1051, 1191, 1273, 1327, 1405, 1512, 1744, 1757, 1804, 1814, 1840, 1847, 2056, 2712, 4095], 'highly': [192, 962], 'likely': [193, 236, 626, 1045, 1193, 1329, 1563, 1746, 1786, 1864, 1951], 'be': [195, 325, 506, 631, 875, 1173, 1419, 1622, 1635, 1685, 1792, 1955, 1993, 2090, 2134], 'manifestations': [197, 240, 1354, 2482], 'fundamental': [201], 'defect—resistance': [202], 'insulin-mediated': [204, 715, 866, 920, 1079], 'disposal': [206, 717, 868, 922, 1081, 1152], 'compensatory': [208, 436, 1205, 1559, 2186], 'hyperinsulinemia,': [209, 991, 1560, 2002, 2187], 'changes': [210, 1053, 1189, 1310, 1799, 3082], 'greatly': [212, 701, 718, 745], 'increase': [213, 1426], 'CHD': [214, 223, 281, 546, 572, 603, 703, 1125, 1141, 1519, 1663, 1692, 1816, 1896, 2047, 2063, 2112, 2143], 'risk.1,2': [215], 'The': [216, 268, 605, 1162, 1465, 1477, 1547, 1694, 1727, 1764, 1899, 2066, 2206, 2211], 'importance': [217, 279, 431, 1729, 2118], 'insulin': [219, 245, 314, 433, 551, 561, 632, 643, 697, 741, 789, 801, 820, 840, 879, 932, 965, 979, 996, 1013, 1039, 1048, 1099, 1104, 1112, 1138, 1164, 1170, 1274, 1409, 1414, 1421, 1480, 1513, 1549, 1589, 1623, 1672, 1682, 1762, 1822, 1858, 1866, 1890, 1919, 1947, 1989, 2032, 2097, 2172, 2904, 3084, 3396, 3749], 'resistance': [220, 434, 705, 802, 821, 841, 1100, 1139, 1410, 1521, 1867, 1920, 2033, 2049, 2173, 2398, 2905, 3085], 'as': [221, 239, 248, 258, 260, 280, 301, 446, 448, 825, 877, 893, 1457, 1907, 1943, 1987, 2058, 2060, 2062, 2073, 2449, 3174, 3434], 'factor': [225], 'first': [227], 'explicated': [228], 'in': [229, 244, 363, 438, 642, 658, 755, 919, 923, 1030, 1054, 1061, 1082, 1157, 1175, 1196, 1312, 1332, 1347, 1356, 1402, 1427, 1433, 1462, 1471, 1491, 1544, 1573, 1681, 1687, 1712, 1741, 1801, 1876, 2034, 2126, 2174, 2250, 2301, 2401, 2427, 2445, 2562, 2569, 2611, 2621, 2688, 2725, 2761, 2815, 2916, 2954, 2989, 3025, 3039, 3083, 3086, 3142, 3278, 3300, 3305, 3310, 3331, 3352, 3403, 3515, 3559, 3562, 3590, 3634, 3751, 3783, 3818, 3889, 3895, 3945, 4003, 4008, 4042, 4067], '1998,': [230], 'cluster': [233, 298, 725, 1343, 2052], 'appear': [238], 'defect': [243, 641], 'action': [246, 3447], 'designated': [247, 296], 'syndrome': [249, 309, 384, 678, 709, 1497, 1658, 1733, 1839, 2192, 2271, 2486, 2716, 2949, 3517, 3558, 3782, 3851, 4041], 'X.1': [250], 'Support': [251], 'notion': [254, 2082], 'has': [255, 275, 336, 686, 1723, 2037, 2043, 3673], 'grown': [256], 'almost': [257, 695, 831, 1094, 1758], 'fast': [259], 'names': [262], 'used': [263, 326, 610, 892, 1108, 1365], 'describe': [265], 'phenomenon.': [267], 'Adult': [269, 3971], 'Treatment': [270], 'Panel': [271], 'III': [272, 323, 373, 455, 476, 535, 681, 771, 1042, 1651, 1703, 2071], '(ATP': [273], 'III)': [274, 353], 'recently3': [276], 'recognized': [277], 'factors': [283, 292, 2417], '“constellation': [286], 'lipid': [288, 2563], 'nonlipid': [290], 'origin,”': [295], '“the': [302], 'syndrome,”': [304], 'indicated': [306], '“this': [308], 'closely': [311], 'linked': [312], 'resistance.”': [315], 'Table': [316, 1031, 1062, 1182, 1313, 1348, 1403, 1545, 1574, 1713, 1742, 1802, 1877, 2127], '1': [317, 357, 2167, 2858, 3041], 'lists': [318], 'criteria': [320, 339, 477, 522, 536, 1024, 1043, 1704, 1934], 'ATP': [322, 372, 454, 475, 534, 680, 770, 1041, 1650, 1702, 1933, 2070], 'stipulated': [324], 'diagnose': [328], 'syndrome,': [331, 737, 1774, 3949], 'recent': [334, 580], 'report4': [335], 'applied': [337], 'database': [342], 'Third': [345], 'National': [346, 2279], 'Health': [347, 2280, 2781, 3311], 'Nutrition': [349, 2282, 3951], 'Examination': [350, 2283], 'Survey': [351], '(NHANES': [352], 'estimated': [355], 'out': [358], '4': [360], 'adults': [361, 2251, 3404], 'living': [362], 'United': [365], 'States': [366], 'merits': [367], 'diagnosis.': [369], 'TABLE': [370, 1216], '1.': [371, 1063], 'Criteria': [374, 766], 'Identification': [376], 'Metabolic': [379, 467, 775, 1644, 2618, 2656, 2730, 2809, 2948, 2967, 3018, 3275, 3344, 3354, 3612, 3632, 3893, 3968, 4068], 'Syndrome3Diagnosis': [380], 'made': [386], 'when': [387, 1753, 1885], '3': [388, 3140], 'or': [389, 888, 1538, 1567, 1719, 2479], 'determinants': [394], 'shown': [395, 648, 1029], 'above': [396, 803], 'present.Abdominal': [398], 'obesity': [399, 783, 838, 911, 2860, 2984, 3479, 3672], '(waist': [400], 'circumference)': [401], 'Men>102': [402], 'cm': [403, 407], '(40': [404], 'in)': [405], 'Women>88': [406], '(35': [408], 'in)Triglycerides≥150': [409], 'mg/dLHDL': [410], 'Men<40': [412], 'mg/dL': [413, 960, 1461], 'Women<50': [414], 'mg/dLBlood': [415], 'pressure≥130/≥85': [416], 'mm': [417], 'HgFasting': [418], 'glucose≥110': [419], 'mg/dLThe': [420], 'goal': [421], 'presentation': [424, 1917], 'put': [427], 'into': [428, 1833, 2115], 'perspective': [429], 'hyperinsulinemia': [437, 1206], 'pathogenesis': [440], 'clinical': [442, 1916, 2104, 3414], 'course': [443], 'CHD,': [445, 621, 754], 'well': [447], 'implications': [450, 1835], 'both': [452, 924, 1137], 'guidelines': [456], 'concerning': [457], 'diagnosis': [459, 1654], 'syndrome.Does': [463], 'Have': [465], 'Syndrome?': [468], 'Is': [469, 760, 1637], 'Insulin': [471, 781, 853, 1148, 1221, 2184, 2397, 3608], 'Resistant?E.C.': [472], 'meets': [473], 'hypertension': [479, 559, 1011, 1019, 1272, 1511, 1967, 4091], 'hypertriglyceridemia.': [481], 'Her': [482], 'waist': [483], 'circumference': [484], 'measured,': [487], 'but': [488, 738, 791, 1431, 1928], 'BMI': [490, 887], 'indicates': [491, 1617], 'overweight,': [496], 'it': [498, 968, 1033, 1526, 1825, 1862, 1949, 1991], 'unlikely': [500, 1035], 'abdominal': [503, 823, 889], 'girth': [504, 890], 'would': [505], '>90': [507], 'cm.': [508], 'Because': [509], 'neither': [510], 'nor': [514, 934, 1598], 'HDL-C': [515, 1058, 1249, 2020], 'were': [518], 'abnormal': [519], 'outlined,': [523], 'does': [525, 537, 673, 1929], 'have': [527, 664, 675, 734, 983, 1065, 1450, 1482, 1853], 'syndrome.However,': [530], 'meeting': [532], 'mean': [539], 'free': [543], 'from': [544, 1369, 1442, 1501, 1678, 1709, 2092, 2276, 3347], 'associated': [548, 638, 1895, 2054, 2713, 2987, 3477, 4096], 'being': [550, 878, 1588, 1988], 'resistant/hyperinsulinemic.': [552], 'Approximately': [553], '50%': [554, 1006], 'patients': [556, 589, 651, 1008, 1016, 1270, 1494, 1508, 2302, 3856, 3946], 'essential': [558, 1010, 1018, 1475, 1510, 1826], 'resistant/hyperinsulinemic,5': [562], 'individual': [565, 628, 1359, 1587, 1620], 'ones': [568], 'most': [569, 1044], 'risk.6,7': [573], 'For': [574], 'example,': [575], 'prospective': [581], 'study': [582, 902, 2426, 2724, 3408], 'showed': [583], 'one-third': [586], 'highest': [592, 1518], 'concentration': [594, 607, 654, 689, 943, 955, 987, 1072, 1105, 1118, 1130, 1240, 1289, 1296, 1378, 1453], 'ratio': [595, 608, 655, 690, 1073, 1119, 1131], 'triglyceride': [598], '(TG)/HDL-C': [599], 'greatest': [602, 949, 1646, 1695], 'risk.7': [604], 'TG/HDL-C': [606, 653, 688, 1071, 1117, 1129], 'because': [611], 'higher': [613, 2006], 'value,': [615, 952], 'greater': [617, 1555, 1582], '8': [622], 'resistant/hyperinsulinemic,': [633, 698, 1422], 'additional': [636], 'action.1,2': [644], 'It': [645], 'also': [647, 843, 1634, 1905], 'whose': [652], 'placed': [656, 1956], 'them': [657, 1616], 'lowest': [660], 'percentile': [661], 'did': [662], 'any': [665, 1613], 'Thus,': [670, 1127, 1794, 1860, 2022], 'although': [671, 1795], 'E.C': [672], 'criteria,': [682, 1783], 'hypertensive,': [685], '4.6,': [692], 'certainly': [696, 832, 1759], 'risk.Insulin': [704, 1520], 'synonymous.': [712], 'Resistance': [713, 854, 3609], 'increases': [719, 1532, 1626], 'likelihood': [721], 'developing': [723, 1536], 'related': [727, 1760, 2123, 2660, 2862], 'described': [729], 'subsequently.': [730], 'may': [732, 796, 1621, 1633, 2089], 'resistant,': [742, 933, 1990], 'develop': [749, 1340, 1565, 1595], 'diabetes': [752, 2454, 2582], 'addition': [756, 1307], 'hypertension.What': [759], 'Relationship': [762, 3627], 'Five': [765], 'Selected': [767], 'Identifying': [773], 'Presence': [779], 'Resistance?Abdominal': [782], 'manifestation': [787], 'resistance,': [790, 997, 2185, 3397], 'an': [792, 1121, 1357, 1551, 1854, 2040, 2766, 3271, 3435, 3482, 3563, 3674, 4098], 'anthropometric': [793], 'variable': [794, 946], 'accentuate': [797, 2000], 'degree': [799, 1203, 1223, 1557], 'due': [805], 'untoward': [808, 1855, 2094], 'effect': [809, 1856, 3514], 'generalized': [811, 828], 'obesity,': [812, 824, 829], 'strength': [815], 'association': [818, 1820], 'between': [819, 837, 956, 1069, 1098, 1914, 2909, 3628, 4036], 'compared': [826, 1458, 3390], 'exaggerated.': [833], 'Indeed,': [834], 'relationship': [836, 1068, 1832, 1913], 'overstated,': [844], 'European': [847, 3189], 'Group': [848], 'Study': [851, 4014], '(EGIR)': [855], 'concluded': [856], 'basis': [859], 'over': [861, 2572], '1100': [862], 'direct': [863, 1706], 'measures': [864], '≈25%': [870, 915, 2084], 'obese': [872], 'individuals': [873, 938, 981, 1050, 1198, 1338, 1417, 1594], 'could': [874], 'classified': [876], 'resistant.': [880, 1590], 'Furthermore,': [881], 'estimate': [883, 1123], 'similar': [885], 'whether': [886, 1718], 'obesity.9': [897], 'Results': [898, 3346], 'bi-ethnic': [901], 'nondiabetic': [904], 'Pima': [905], 'Indians': [906], 'Caucasians': [908], 'found': [909, 1087], 'accounted': [913], 'variability': [918], 'ethnic': [925], 'groups.': [926], 'Not': [927, 1335, 1591], 'all': [928, 936, 1336, 1592, 1815], 'subjects': [930], 'insulin-resistant': [937, 1197, 1358, 1593, 1604], 'overweight.The': [939], 'positive': [950], 'predictive': [951, 963], '110': [957, 1383], '126': [959], 'resistance/hyperinsulinemia.': [966, 1763], 'However,': [967, 1982], 'sensitive': [972, 1165], 'indicator,': [973], 'vast': [976], 'majority': [977], 'resistant/hyperinsulinemic': [980, 1049, 1514], 'will': [982, 1339, 1360, 1449, 1705, 1791, 1888, 1904, 1954, 1992, 1999], '<110': [988], 'mg/dL.': [989], 'Although': [990], 'surrogate': [993, 1109], 'measure': [994, 1077, 1110], 'predicts': [998, 3555], 'development': [1000, 2420, 2478], 'hypertension,10,11': [1002], 'no': [1003], 'than': [1005, 1750, 1776, 2144], 'resistant.5': [1014], 'If': [1015, 1939], 'do': [1020, 1485], 'meet': [1022, 1931], 'hyperglycemia': [1026], 'dyslipidemia': [1028], '1,': [1032], 'they': [1037, 1754, 1756, 1813], 'resistant/hyperinsulinemic.The': [1040], 'identify': [1047], 'TG': [1056, 1429, 1452, 2007], 'listed': [1060, 1311, 1346, 1401, 1543, 1572, 1740, 1800, 1875, 2125], 'We': [1064], 'examined': [1066], 'specific': [1076, 1779], '≈400': [1083], 'healthy': [1084], 'volunteers': [1085], 'correlation': [1090], 'coefficient': [1091], '(r=0.6)': [1092], 'identical': [1095], '(a': [1106], 'commonly': [1107], 'resistance).': [1113], 'In': [1114, 1371, 1395], 'addition,': [1115, 1396], 'provides': [1120, 3512], 'independent': [1122], 'risk.8': [1126], 'powerful': [1134], 'predictor': [1135, 2451], 'risk.What': [1142], 'Are': [1143, 3146], 'Disease-Related': [1145], 'Consequences': [1146], 'Resistance/Compensatory': [1149], 'Hyperinsulinemia?Insulin-mediated': [1150], 'muscle': [1154, 3399], 'varies': [1155], '≈10-fold': [1156], 'healthy,': [1158], 'nondiabetic,': [1159], 'normotensive': [1160], 'individuals.': [1161, 1334, 1605], 'muscle,': [1167], 'less': [1169], 'needs': [1171], 'secreted': [1174], 'order': [1176], 'maintain': [1178, 1201], 'homeostasis.': [1181], 'presents': [1184], 'list': [1186], 'occur': [1195, 1331, 1748], 'able': [1199], 'needed': [1207], 'prevent': [1209, 2476], 'onset': [1211], 'diabetes.': [1215], '2.': [1217, 1546, 1575], 'Abnormalities': [1218], 'Associated': [1219, 3147], 'With': [1220], 'Resistance/HyperinsulinemiaSome': [1222], 'intolerance': [1226], 'Impaired': [1227, 1230], 'toleranceAbnormal': [1232], 'uric': [1233, 1238, 1243, 3553], 'acid': [1234, 1239, 1244, 3554], 'metabolism': [1235, 1683, 3944], '↑': [1236, 1246, 1253, 1256, 1261, 1265, 1276, 1280, 1283, 1287, 1294], 'Plasma': [1237, 1288, 1295], '↓': [1241, 1248, 1250, 1301], 'Renal': [1242, 1262], 'clearanceDyslipidemia': [1245], 'Triglycerides': [1247], 'LDL-particle': [1251], 'diameter': [1252], 'Postprandial': [1254], 'lipemiaHemodynamic': [1255], 'Sympathetic': [1257], 'nervous': [1258], 'system': [1259], 'activity': [1260], 'sodium': [1263], 'retention': [1264], 'Blood': [1266], '(≈50%': [1268], 'resistant)Hemostatic': [1275], 'Plasminogen': [1277], 'activator': [1278], 'inhibitor-1': [1279], 'FibrinogenEndothelial': [1281], 'dysfunction': [1282, 2533], 'Mononuclear': [1284], 'cell': [1285, 3679], 'adhesion': [1286, 1292], 'cellular': [1291], 'molecules': [1293], 'asymmetric': [1298], 'dimethyl': [1299], 'arginine': [1300], 'Endothelial-dependent': [1302], 'vasodilatationReproductive': [1303], 'Polycystic': [1304], 'ovary': [1305], 'syndromeIn': [1306], '2,': [1314, 1349, 1878, 2128], 'there': [1315, 1808, 2139], 'increasing': [1317], 'evidence': [1318, 1811], 'nonalcoholic': [1320], 'steatohepatitis': [1321], 'several': [1323], 'forms': [1324], 'cancer': [1326, 3476], 'insulin-resistant/hyperinsulinemic': [1333, 1337], 'entire': [1342], 'number': [1352], 'present': [1355], 'vary': [1361, 1906], 'cut-point': [1364], 'separate': [1367], 'abnormal.': [1370], 'case': [1373, 1473], 'E.C.,': [1375], '103': [1380], 'mg/dL,': [1381, 1384, 1456], 'why': [1386], 'diagnosed': [1390], 'syndrome.': [1394, 1726, 1938], 'none': [1397], 'solely': [1406], 'regulated': [1407], 'and/or': [1411], 'concentration.': [1415], 'Two': [1416], 'can': [1418], 'equally': [1420], 'comparable': [1425], 'hepatic': [1428], 'secretion,': [1430], 'differ': [1432], 'terms': [1434], 'their': [1436, 1600, 1819], 'ability': [1437], 'remove': [1439], 'TG-rich': [1440], 'lipoproteins': [1441], 'plasma.': [1443], 'As': [1444], 'consequence,': [1446], 'one': [1447, 1537, 1566, 1614], 'subject': [1448], '140': [1455], '180': [1460], 'other.': [1464], 'situation': [1466], 'even': [1468], 'complicated': [1470], 'hypertension.': [1476], 'fact': [1478], 'resistance//hyperinsulinemia': [1481], 'nothing': [1483], '≈50%': [1492], 'should': [1498], 'detract': [1500], 'understanding': [1502], 'substantial': [1505, 1810], 'proportion': [1506], 'disease;': [1525], 'physiological': [1529], 'change': [1530], 'resistant': [1550, 1624], 'individual,': [1552], 'Conversely,': [1576], 'present,': [1580, 1869], 'chances': [1584], 'abnormalities,': [1597], 'appearance': [1601], 'confined': [1602], 'On': [1606], 'other': [1608, 1631], 'hand,': [1609], 'presence': [1611], 'possibility': [1628], 'present.What': [1636], 'Clinical': [1639, 3152, 3279, 3492, 3879, 4051], 'Utility': [1640], 'Diagnosing': [1642], 'Syndrome?The': [1645], 'benefit': [1647], 'approach': [1652, 1901, 3484], 'recognition': [1661, 2076], 'limited': [1667], 'hypercholesterolemia,': [1669], 'resistance/hyperinsulinemia': [1673, 1823], 'consequences': [1676, 2095], 'stemming': [1677], 'defects': [1680], 'must': [1684, 2113], 'considered': [1686, 1975], 'efforts': [1688, 1829, 2109], 'aimed': [1689], 'decreasing': [1691], 'risk.': [1693], 'danger': [1696], 'use': [1699], 'attention': [1707, 1766], 'away': [1708], 'information': [1711], 'focus': [1716, 2025, 3443], 'patient': [1722], 'conceptual': [1728], 'indicate': [1736], 'together': [1749], 'separately,': [1751], 'cluster,': [1755], 'paid': [1767], 'concept': [1770], 'rather': [1775], 'set': [1780], 'arbitrary': [1782], 'appropriate': [1788], 'therapeutic': [1789, 1828, 1900, 2132], 'decisions': [1790], 'made.': [1793], 'many': [1796], 'measured': [1806], 'routinely,': [1807], 'risks,': [1817], 'makes': [1824], 'take': [1830, 2114], 'consideration.Therapeutic': [1834], 'self-evident.': [1841], 'Excess': [1842], 'adiposity': [1843], 'inactivity': [1846], 'major': [1849], 'lifestyle': [1850], 'action.2': [1859], 'once': [1861], 'seems': [1863], 'leading': [1871, 2003], 'weight': [1879], 'loss': [1880], 'activity,': [1884], 'appropriately': [1886], 'initiated,': [1887, 1968], 'enhance': [1889], 'sensitivity': [1891, 3750], 'decrease': [1893], 'factors.': [1898, 2065], 'function': [1909, 3402], 'how': [1911], 'perceived.': [1922], 'hypercholesterolemic,': [1927], 'interpreted': [1942], 'meaning': [1944], 'sensitive,': [1948], 'low': [1959, 2325, 2955], 'fat–high': [1960], 'carbohydrate': [1961, 2474], 'diet,': [1962], 'drug': [1963], 'pharmacological': [1970], 'hypercholesterolemia': [1974, 2061], 'after': [1976], 'period': [1978], 'dietary': [1980, 4037], 'intervention.': [1981], 'if': [1983], 'perceived': [1986], 'realized': [1994], 'prescribed': [1997], 'diet': [1998], 'concentration,': [2008], 'enhanced': [2009], 'postprandial': [2010], 'lipemia,': [2011], 'smaller': [2012], 'denser': [2014], 'LDL': [2015], 'particles,': [2016], 'lower': [2019], 'concentration.12': [2021], 'failure': [2023], 'central': [2028], 'role': [2029], 'played': [2030], 'instance': [2036], 'led': [2038], 'intervention': [2041], 'increased,': [2044], 'decreased,': [2046], 'risk.ConclusionInsulin': [2048], 'its': [2051, 2718, 3486, 3853], 'probably': [2057], 'important': [2059], 'report': [2067, 2231], 'serves': [2072], 'formal': [2075], 'fact,3': [2079], 'US': [2087, 2273, 2632], 'population': [2088, 2448], 'suffering': [2091], 'resistance4': [2098], 'emphasizes': [2099], 'magnitude': [2101], 'problem.': [2105], 'Given': [2106], 'information,': [2108], 'reduce': [2111], 'account': [2116], 'series': [2121], 'new': [2131], 'approaches': [2133], 'evaluated': [2135], 'recognize': [2137], 'hypercholesterolemia.FootnotesCorrespondence': [2145], 'MD,': [2149], '300': [2157], 'Pasteur': [2158], 'Dr,': [2159], 'CA': [2161], '94305.': [2162], 'E-mail': [2163], '[email': [2164], 'protected]': [2165], 'References': [2166], 'GM.': [2169, 2183, 2471], 'Role': [2170], 'human': [2175], 'disease.': [2176, 2336, 2360], 'Diabetes.': [2177], '1988;': [2178], '37:': [2179], '1595–1600.CrossrefMedlineGoogle': [2180], 'Scholar2': [2181], 'disease:': [2191, 2460], 'X': [2193], 'revisited.': [2194, 2464], 'In:': [2195], 'Jefferson': [2196], 'LS,': [2197], 'Cherrington': [2198], 'AD,': [2199], 'eds.': [2200], 'Handbook': [2201], 'Physiology,': [2203], 'Section': [2204], '7,': [2205], 'Endocrine': [2207, 2212], 'System,': [2208], 'Vol': [2209], 'II,': [2210], 'Pancreas': [2213], 'Regulation': [2215], 'Metabolism.': [2217, 2465], 'New': [2218], 'York,': [2219], 'NY:': [2220], 'Oxford': [2221], 'University': [2222, 2650], 'Press;': [2223], '2001:1169–1197.Google': [2224], 'Scholar3': [2225], 'Executive': [2226], 'summary': [2227], 'third': [2230, 2278], 'national': [2234], 'education': [2236], 'program': [2237], '(NCEP)': [2238], 'expert': [2239], 'panel': [2240, 2254], 'detection,': [2242], 'evaluation,': [2243], 'high': [2247, 2304, 2473], '(adult': [2252], 'III).': [2255], 'JAMA.': [2256, 2285], '2001;': [2257, 2364], '285:': [2258], '2846–2497.CrossrefGoogle': [2259], 'Scholar4': [2260], 'Ford': [2261], 'ES,': [2262], 'Giles': [2263], 'WH,': [2264], 'Dietz': [2265], 'WH.': [2266], 'Prevalence': [2267, 2298, 2807, 3093, 3779, 3848], 'among': [2272, 2811, 2950, 3855], 'adults:': [2274], 'findings': [2275], 'Survey.': [2284], '2002;': [2286], '287:': [2287], '356–359.CrossrefMedlineGoogle': [2288], 'Scholar5': [2289], 'Zavaroni': [2290, 2436], 'I,': [2291, 2437, 3256], 'Mazza': [2292], 'S,': [2293, 2515, 2635, 2637, 2976, 3064, 3068, 3114, 3120, 3199, 3205, 3318, 3462, 3466, 3770], 'Dall’Aglio': [2294], 'E,': [2295, 2390, 2746, 2939, 3543, 3733, 3801, 3841, 3982], 'et': [2296, 2320, 2348, 2373, 2395, 2442], 'al.': [2297, 2321, 2349, 2374, 2396, 2443], 'hyperinsulinaemia': [2300], 'pressure.': [2306], 'J': [2307, 2403, 2430, 3076, 3267, 3382, 3929, 4061], 'Int': [2308, 2362], 'Med.': [2309, 2363], '1992;': [2310], '31:': [2311], '1128–1130.CrossrefGoogle': [2312], 'Scholar6': [2313], 'Jeppesen': [2314, 2342], 'J,': [2315, 2343, 2744, 3062, 3260, 3367, 3369, 3377, 3620, 3690, 3909, 3917], 'Hein': [2316, 2344], 'HO,': [2317, 2345, 2413], 'Suadicani': [2318, 2346], 'P,': [2319, 2347, 2394, 2441, 2553, 3254, 3657, 3927, 3980, 3986], 'High': [2322], 'HDL': [2326, 4000], 'ischemic': [2334, 2358], 'Hypertension.': [2337], '2000;': [2338], '36:': [2339], '226–232.CrossrefMedlineGoogle': [2340], 'Scholar7': [2341], 'Low': [2350, 3996], 'triglycerides-high': [2351], 'Arch': [2361], '161:': [2365], '361–366.CrossrefMedlineGoogle': [2366], 'Scholar8': [2367], 'Gaziano': [2368], 'JM,': [2369], 'Hennekens': [2370], 'CH,': [2371], 'O’Donnell,': [2372], 'Fasting': [2375], 'triglycerides,': [2376], 'lipoprotein,': [2378], 'myocardial': [2382], 'infarction.': [2383], 'Circulation.': [2384], '1997;': [2385, 2406, 2495], '96:': [2386], '2520–2525.CrossrefMedlineGoogle': [2387], 'Scholar9': [2388], 'Ferrannini': [2389], 'Natali': [2391], 'A,': [2392, 2549, 2601, 2639, 2697, 2794, 2798, 2937, 3002, 3066, 3209, 3502, 3537, 3581, 3735, 3766, 3913, 4080], 'Bell': [2393], 'hypersecretion': [2400], 'obesity.': [2402], 'Clin': [2404], 'Invest.': [2405], '100:': [2407], '1166–1173.CrossrefMedlineGoogle': [2408], 'Scholar10': [2409], 'Skarfors': [2410], 'ET,': [2411], 'Lithell': [2412], 'Selinus': [2414], 'I.': [2415], 'Risk': [2416], 'hypertension:': [2422], '10-year': [2424, 2721], 'longitudinal': [2425], 'middle-aged': [2428], 'men.': [2429], 'Hypertens.': [2431], '1991;': [2432], '9:': [2433], '217–223.CrossrefMedlineGoogle': [2434], 'Scholar11': [2435], 'Bonini': [2438], 'L,': [2439, 3006, 3112, 3126, 3373, 3729, 4028, 4078], 'Gasparini': [2440], 'Hyperinsulinemia': [2444], 'non-insulin–dependent': [2453], 'mellitus,': [2455], 'Barilla': [2462], 'factory': [2463], '1999;': [2466], '48:': [2467], '989–994.CrossrefMedlineGoogle': [2468], 'Scholar12': [2469], 'Do': [2472], 'diets': [2475, 3747], 'attenuate': [2480], '(or': [2483], 'both)': [2484], 'X?': [2487], 'A': [2488, 2555, 2584, 2703, 2805, 2818, 2856, 2943, 3029, 3043, 3133, 3188, 3218, 3232, 3702, 3843, 3863, 4012], 'viewpoint': [2489], 'strongly': [2490], 'against.': [2491], 'Cur': [2492], 'Opin': [2493], 'Lipidology.': [2494], '8:': [2496], '23–27.CrossrefMedlineGoogle': [2497], 'Scholar': [2498], 'Previous': [2499], 'Back': [2500], 'top': [2502], 'Next': [2503], 'FiguresReferencesRelatedDetailsCited': [2504], 'By': [2505], 'Dai': [2506], 'H,': [2507, 3320, 3427, 3803, 3925, 3984], 'Fu': [2508], 'Q,': [2509], 'Xu': [2510], 'K,': [2511], 'Sun': [2512], 'M,': [2513, 2633, 2699, 2843, 2845, 3118, 3201, 3203, 3207, 3211, 3213, 3248, 3258, 3371, 3425, 3504, 3541, 3545, 3659, 3661, 3731, 3768, 3835, 4026], 'Kasyanju': [2514], 'Shi': [2516], 'Y': [2517, 2892, 3079, 3622], 'Yang': [2519, 3326], 'T': [2520, 2605, 2641, 2946, 3678], '(2022)': [2521, 2559], 'Constructing': [2522], 'integral': [2525], 'score': [2526], 'model': [2527, 2768], 'quantification': [2530], 'tendency,': [2535], 'Nutrition,': [2536, 3280], 'Metabolism': [2537], 'Diseases,': [2540], '10.1016/j.numecd.2021.12.014,': [2541], '32:3,': [2542], 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[2574], 'year': [2575], 'follow-up': [2576], 'future': [2578], 'type2': [2581], 'mellitus:': [2583], 'latent': [2585], 'growth': [2586], 'modeling': [2587], 'approach,': [2588], 'Alexandria': [2589], 'Journal': [2590, 2664, 2776, 2871, 3239, 3453, 3488, 3524, 3638, 3753, 4018], 'Medicine,': [2592, 2623, 3242, 3615, 3825], '10.1080/20905068.2022.2062958,': [2593], '58:1,': [2594], '(52-59),': [2595], '31-Dec-2022.': [2599], 'Hevener': [2600], 'Ribas': [2602], 'V,': [2603, 3124, 3291, 3468], 'Moore': [2604], 'Zhou': [2607], 'Z': [2608], '(2021)': [2609, 2646, 2677, 2707, 2806], 'ERα': [2610], 'Control': [2613], 'Mitochondrial': [2615], 'Function': [2616], 'Health,': [2619, 2690], 'Trends': [2620], 'Molecular': [2622, 3950], '10.1016/j.molmed.2020.09.006,': [2624], '27:1,': [2625], '(31-46),': [2626], '1-Jan-2021.': [2630], 'Rao': [2631, 2840], 'Siddharthan': [2634], 'R': [2636, 2981], 'Sathivel': [2638], 'Zin': [2640], 'Bhaskar': [2643], 'Raj': [2644], 'N': [2645, 2978, 3963], 'Assessment': [2647], 'Malaysian': [2649], 'Undergraduate’s': [2651], 'Knowledge': [2652], 'Awareness': [2654], 'Conditions': [2659], 'it,': [2662], 'Pharmacy': [2666], 'Technology,': [2668], '10.52711/0974-360X.2021.00334,': [2669], '(1893-1898),': [2670], '29-Apr-2021.': [2674], 'Ma': [2675], 'Q': [2676], 'Toward': [2678], 'Eradicating': [2679], 'All': [2680], 'Diseases': [2681], 'Technological': [2682], 'Breakthroughs': [2683], 'Future': [2685], 'Business': [2686], 'Opportunities': [2687], 'Education,': [2689], 'Outer': [2692], 'Space,': [2693], '10.4018/978-1-7998-6772-2.ch014,': [2694], '(220-239)': [2695], 'Zahedi': [2696], 'Akbarzadeh': [2698], 'Sedaghati-Khayat': [2700], 'B,': [2701, 3004, 3837], 'Seyedhamzehzadeh': [2702], 'Daneshpour': [2705], 'GCKR': [2708], 'common': [2709], 'functional': [2710], 'polymorphisms': [2711], 'components:': [2719], 'retrospective': [2722], 'cohort': [2723], 'Iranian': [2726], 'adults,': [2727, 4047], 'Diabetology': [2728, 2965], '&': [2729, 2926, 2966, 3052, 3098, 3491, 3952, 4050], 'Syndrome,': [2731, 2968, 3276], '10.1186/s13098-021-00637-4,': [2732], '13:1,': [2733], '1-Dec-2021.': [2737], 'Barros': [2738], 'R,': [2739, 3108, 3116, 3250, 3289, 3375, 3460, 3760, 3915, 3978], 'Alvim-Silva': [2740], 'T,': [2741, 2800, 3070, 3322, 3692, 3764], 'de': [2742], 'Souza': [2743], 'Marques': [2745], 'Rocha': [2747, 3125], 'N,': [2748, 3839, 4082], 'Brito': [2749], 'F': [2750, 3008], 'Scaramello': [2752], 'C': [2753, 3324, 3550, 3606, 3991], '(2020)': [2754, 2853, 2896, 2947, 2982, 3036, 3080, 3134], 'Biometric,': [2755], 'nutritional,': [2756], 'biochemical,': [2757], 'cardiovascular': [2759], 'outcomes': [2760], 'male': [2762], 'rats': [2763, 3518], 'submitted': [2764], 'experimental': [2767], 'early': [2770], 'weaning': [2771], 'mimics': [2773], 'mother': [2774], 'abandoning,': [2775], 'Developmental': [2778], 'Origins': [2779], 'Disease,': [2783, 3313], '10.1017/S2040174420000793,': [2784], '12:3,': [2785], '(523-529),': [2786], '1-Jun-2021.': [2790], 'Bitew': [2791, 2934], 'Z,': [2792, 2796, 2935, 2941], 'Alemu': [2793, 2936], 'Tenaw': [2795, 2940], 'Alebel': [2797, 2942], 'Worku': [2799, 2945], 'Ayele': [2801, 2938], 'E': [2802, 3603, 3932], 'Abbara': [2804], 'Children': [2812], 'Adolescents': [2814], 'High-Income': [2816], 'Countries:': [2817], 'Systematic': [2819], 'Review': [2820], 'Meta-Analysis': [2822], 'Observational': [2824], 'Studies,': [2825], 'BioMed': [2826], 'International,': [2828], '10.1155/2021/6661457,': [2829], '2021,': [2830], '(1-24),': [2831], '26-Mar-2021.': [2835], 'Mao': [2836], 'X,': [2837, 2886, 2888], 'Huang': [2838, 2851], 'D,': [2839, 3694, 3772], 'C,': [2841, 3110, 3122, 3128, 3262, 3727, 3762, 3919], 'Du': [2842], 'Liang': [2844], 'Li': [2846], 'Liu': [2848, 2891, 2894], 'B': [2849, 3035, 3509], 'K': [2852, 3877, 4064], 'Enoyl': [2854], 'coenzyme': [2855], 'hydratase': [2857], 'combats': [2859], 'disorders': [2864], 'promoting': [2866], 'adipose': [2867], 'tissue': [2868], 'browning,': [2869], 'American': [2870], 'Physiology-Endocrinology': [2873], 'Metabolism,': [2875, 2993, 3053, 3681, 3792], '10.1152/ajpendo.00424.2019,': [2876], '318:3,': [2877], '(E318-E329),': [2878], '1-Mar-2020.': [2882, 3000], 'Chen': [2883, 3317], 'G,': [2884, 3074, 3165, 3697, 3911, 3923], 'Fan': [2885], 'Zheng': [2887], 'Jin': [2889], 'Y,': [2890, 3072], 'S': [2895, 3011, 3167, 3264, 3293, 3470, 3473, 3547, 3741, 3777, 3808], 'Human': [2897], 'umbilical': [2898], 'cord-derived': [2899], 'mesenchymal': [2900], 'stem': [2901], 'cells': [2902], 'ameliorate': [2903], 'via': [2906, 3519], 'PTEN-mediated': [2907], 'crosstalk': [2908], 'PI3K/Akt': [2911], 'Erk/MAPKs': [2913], 'signaling': [2914], 'pathways': [2915], 'skeletal': [2918, 3398], 'muscles': [2919], 'db/db': [2921], 'mice,': [2922], 'Stem': [2923], 'Cell': [2924, 3144, 4005], 'Therapy,': [2927], '10.1186/s13287-020-01865-7,': [2928], '11:1,': [2929], '1-Dec-2020.': [2933, 2974], 'children': [2951, 3087], 'adolescents': [2953], 'middle': [2957], 'income': [2958], 'countries:': [2959], 'systematic': [2961, 3233], 'review': [2962, 3044, 3234], 'meta-analysis,': [2964], '10.1186/s13098-020-00601-8,': [2969], '12:1,': [2970], 'Caprio': [2975], 'Santoro': [2977], 'Weiss': [2980], 'Childhood': [2983], 'rise': [2988], 'cardiometabolic': [2990, 3225], 'complications,': [2991], 'Nature': [2992], '10.1038/s42255-020-0183-z,': [2994], '2:3,': [2995], '(223-232),': [2996], 'Oyewande': [3001], 'Iqbal': [3003], 'Abdalla': [3005], 'Karim': [3007], 'Khan': [3010], 'An': [3012], 'Overview': [3013], 'Pathophysiology': [3016], 'Changes': [3019, 4066], 'Their': [3021], 'Sequence': [3022], 'Occurrence': [3024], 'Obese': [3026], 'Diabetic': [3027], 'Females:': [3028], 'Narrative': [3030], 'Review,': [3031], 'Cureus,': [3032], '10.7759/cureus.10947': [3033], 'Vergès': [3034], 'diabetes:': [3042, 3442, 3481], 'epidemiological': [3046], 'data': [3047], 'underlying': [3049], 'mechanisms,': [3050], 'Diabetes': [3051], '10.1016/j.diabet.2020.09.001,': [3054], '46:6,': [3055], '(442-449),': [3056], '1-Nov-2020.': [3060, 3106], 'Kong': [3061], 'Nam': [3063], 'Ko': [3065], 'Byun': [3067], 'Lim': [3069], 'Kim': [3071], 'Yeon': [3073], 'Cho': [3075], 'Lee': [3078, 3621, 3802, 3804], 'Longitudinal': [3081], 'epilepsy': [3089], 'ketogenic': [3091], 'diet:': [3092], 'factors,': [3096, 3227], 'Epilepsy': [3097], 'Behavior,': [3099], '10.1016/j.yebeh.2020.107393,': [3100], '112,': [3101], '(107393),': [3102], 'Santiago': [3107], 'Figueiredo': [3109], 'Fiuza': [3111], 'Yahouédéhou': [3113], 'Oliveira': [3115], 'Aleluia': [3117], 'Carvalho': [3119, 3773], 'Fonseca': [3121], 'Nascimento': [3123], 'Guarda': [3127], 'Gonçalves': [3129], 'Kleinjan': [3132], 'Transforming': [3135], 'Factor': [3137], 'Beta': [3138], 'Receptor': [3139], 'Haplotypes': [3141], 'Sickle': [3143, 4004], 'Lipid': [3149], 'Profile': [3150], 'Manifestations,': [3153], 'Mediators': [3154], 'Inflammation,': [3156], '10.1155/2020/3185015,': [3157], '2020,': [3158], '(1-18),': [3159], '13-Oct-2020.': [3163], 'Locke': [3164], 'Bernhard': [3166], 'Senge': [3169], '(2019)': [3171, 3219, 3268], 'Nonconjugated': [3172], 'Hydrocarbons': [3173], 'Rigid‐Linear': [3175], 'Motifs:': [3176], 'Isosteres': [3177], 'Material': [3179], 'Sciences': [3180], 'Bioorganic': [3182], 'Medicinal': [3184], 'Chemistry,': [3185], 'Chemistry': [3186], '–': [3187], 'Journal,': [3190], '10.1002/chem.201804225,': [3191], '25:18,': [3192], '(4590-4647),': [3193], '27-Mar-2019.': [3197], 'Djalalinia': [3198], 'Khosravi': [3200], 'Hasani': [3202], 'Moghaddam': [3204], 'Atoofi': [3206], 'Mahdavi-Gorabi': [3208], 'Noroozi': [3210], 'Qorbani': [3212], 'Asayesh': [3214], 'H': [3215, 3327, 3506, 3665], 'Soleimani': [3217], 'Effects': [3220, 3333], 'selenium': [3222], 'supplementation': [3223], 'inflammatory,': [3228], 'antioxidant': [3230], 'markers:': [3231], 'meta-analysis': [3236], 'protocol,': [3237], 'International': [3238], 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