Publication Information

{'id': 'https://openalex.org/W2161052699', 'doi': 'https://doi.org/10.1128/jb.184.1.233-240.2002', 'title': 'Tn <i>5</i> Transposase with an Altered Specificity for Transposon Ends', 'display_name': 'Tn <i>5</i> Transposase with an Altered Specificity for Transposon Ends', 'publication_year': 2002, 'publication_date': '2002-01-01', 'ids': {'openalex': 'https://openalex.org/W2161052699', 'doi': 'https://doi.org/10.1128/jb.184.1.233-240.2002', 'mag': '2161052699', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11741865', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/134785'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/jb.184.1.233-240.2002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S133274750', 'display_name': 'Journal of Bacteriology', 'issn_l': '0021-9193', 'issn': ['0021-9193', '1067-8832', '1098-5530'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc134785?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5085595035', 'display_name': 'Todd A. Naumann', 'orcid': 'https://orcid.org/0000-0002-7446-3230'}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Todd A. Naumann', 'raw_affiliation_strings': ['Department of Biochem-istry, University of Wisconsin-Madison, 433 Babcock Dr., Madison, WI 53706.', 'Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin', 'institution_ids': ['https://openalex.org/I135310074']}, {'raw_affiliation_string': 'Department of Biochem-istry, University of Wisconsin-Madison, 433 Babcock Dr., Madison, WI 53706.', 'institution_ids': ['https://openalex.org/I135310074']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110056272', 'display_name': 'William S. Reznikoff', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135310074', 'display_name': 'University of Wisconsin–Madison', 'ror': 'https://ror.org/01y2jtd41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I135310074']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'William S. Reznikoff', 'raw_affiliation_strings': ['Department of Biochem-istry, University of Wisconsin-Madison, 433 Babcock Dr., Madison, WI 53706.', 'Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin', 'institution_ids': ['https://openalex.org/I135310074']}, {'raw_affiliation_string': 'Department of Biochem-istry, University of Wisconsin-Madison, 433 Babcock Dr., Madison, WI 53706.', 'institution_ids': ['https://openalex.org/I135310074']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5110056272'], 'corresponding_institution_ids': ['https://openalex.org/I135310074'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.315, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.856544, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '184', 'issue': '1', 'first_page': '233', 'last_page': '240'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10120', 'display_name': 'Bacterial Genetics and Biotechnology', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10120', 'display_name': 'Bacterial Genetics and Biotechnology', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11470', 'display_name': 'Legume Nitrogen Fixing Symbiosis', 'score': 0.9869, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10207', 'display_name': 'Advanced biosensing and bioanalysis techniques', 'score': 0.9806, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transposase', 'display_name': 'Transposase', 'score': 0.94008756}, {'id': 'https://openalex.org/keywords/transposon-mutagenesis', 'display_name': 'Transposon mutagenesis', 'score': 0.75925624}, {'id': 'https://openalex.org/keywords/p-element', 'display_name': 'P element', 'score': 0.68752223}, {'id': 'https://openalex.org/keywords/transposition', 'display_name': 'Transposition (logic)', 'score': 0.6263476}, {'id': 'https://openalex.org/keywords/bacteriophage-mu', 'display_name': 'Bacteriophage Mu', 'score': 0.47728935}, {'id': 'https://openalex.org/keywords/tn10', 'display_name': 'Tn10', 'score': 0.43754748}], 'concepts': [{'id': 'https://openalex.org/C172510086', 'wikidata': 'https://www.wikidata.org/wiki/Q410629', 'display_name': 'Transposase', 'level': 5, 'score': 0.94008756}, {'id': 'https://openalex.org/C4918238', 'wikidata': 'https://www.wikidata.org/wiki/Q121438', 'display_name': 'Transposable element', 'level': 4, 'score': 0.91950023}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.89773047}, {'id': 'https://openalex.org/C28693550', 'wikidata': 'https://www.wikidata.org/wiki/Q7835335', 'display_name': 'Transposon mutagenesis', 'level': 5, 'score': 0.75925624}, {'id': 'https://openalex.org/C160775987', 'wikidata': 'https://www.wikidata.org/wiki/Q411599', 'display_name': 'P element', 'level': 5, 'score': 0.68752223}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.63693553}, {'id': 'https://openalex.org/C12455157', 'wikidata': 'https://www.wikidata.org/wiki/Q7835331', 'display_name': 'Transposition (logic)', 'level': 2, 'score': 0.6263476}, {'id': 'https://openalex.org/C16318435', 'wikidata': 'https://www.wikidata.org/wiki/Q149299', 'display_name': 'Mutagenesis', 'level': 4, 'score': 0.56853724}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.4892571}, {'id': 'https://openalex.org/C2779637723', 'wikidata': 'https://www.wikidata.org/wiki/Q6930650', 'display_name': 'Bacteriophage Mu', 'level': 5, 'score': 0.47728935}, {'id': 'https://openalex.org/C101425835', 'wikidata': 'https://www.wikidata.org/wiki/Q4051531', 'display_name': 'Tn10', 'level': 5, 'score': 0.43754748}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.41069373}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.33681768}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.33486298}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1974774}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004251', 'descriptor_name': 'DNA Transposable Elements', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D019895', 'descriptor_name': 'Transposases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004251', 'descriptor_name': 'DNA Transposable Elements', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019020', 'descriptor_name': 'Directed Molecular Evolution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018698', 'descriptor_name': 'Glutamic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018698', 'descriptor_name': 'Glutamic Acid', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017354', 'descriptor_name': 'Point Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011995', 'descriptor_name': 'Recombination, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012091', 'descriptor_name': 'Repetitive Sequences, Nucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012641', 'descriptor_name': 'Selection, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019895', 'descriptor_name': 'Transposases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019895', 'descriptor_name': 'Transposases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019895', 'descriptor_name': 'Transposases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D014633', 'descriptor_name': 'Valine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014633', 'descriptor_name': 'Valine', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/jb.184.1.233-240.2002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S133274750', 'display_name': 'Journal of Bacteriology', 'issn_l': '0021-9193', 'issn': ['0021-9193', '1067-8832', '1098-5530'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc134785', 'pdf_url': 'https://europepmc.org/articles/pmc134785?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC134785', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11741865', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc134785', 'pdf_url': 'https://europepmc.org/articles/pmc134785?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1546783991', 'https://openalex.org/W1570352759', 'https://openalex.org/W1953270925', 'https://openalex.org/W1975495433', 'https://openalex.org/W1980829286', 'https://openalex.org/W1991992091', 'https://openalex.org/W2006378465', 'https://openalex.org/W2011513747', 'https://openalex.org/W2020413336', 'https://openalex.org/W2026262126', 'https://openalex.org/W2030735657', 'https://openalex.org/W2031673350', 'https://openalex.org/W2040512193', 'https://openalex.org/W2065599549', 'https://openalex.org/W2071086763', 'https://openalex.org/W2076258014', 'https://openalex.org/W2087823077', 'https://openalex.org/W2124583402', 'https://openalex.org/W2139601584', 'https://openalex.org/W2144634347', 'https://openalex.org/W2155439940'], 'related_works': ['https://openalex.org/W4312081968', 'https://openalex.org/W2322695924', 'https://openalex.org/W2161052699', 'https://openalex.org/W2132162611', 'https://openalex.org/W2122874132', 'https://openalex.org/W2117606302', 'https://openalex.org/W2114081266', 'https://openalex.org/W2097178552', 'https://openalex.org/W2013002258', 'https://openalex.org/W1801353832'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Tn': [1, 37], '5': [2, 38], 'is': [3, 57, 110, 148], 'a': [4, 10, 89, 139], 'composite': [5], 'bacterial': [6], 'transposon': [7], 'that': [8, 109, 147], 'encodes': [9], 'protein,': [11], 'transposase': [12, 78], '(Tnp),': [13], 'required': [14], 'for': [15, 150], 'movement': [16, 81], 'of': [17, 30, 77, 82, 88, 105, 116, 118], 'the': [18, 24, 75], 'transposon.': [19], 'The': [20], 'initial': [21], 'step': [22], 'in': [23, 123, 126, 153], 'transposition': [25, 117], 'pathway': [26], 'involves': [27], 'specific': [28, 42], 'binding': [29], 'Tnp': [31, 71, 107], 'to': [32, 79, 112], '19-bp': [33], 'end': [34, 43, 47, 51, 154], 'recognition': [35, 69], 'sequences.': [36], 'contains': [39, 138], 'two': [40], 'different': [41], 'sequences,': [44], 'termed': [45], 'outside': [46], '(OE)': [48], 'and': [49, 72, 125], 'inside': [50], '(IE).': [52], 'In': [53], 'Escherichia': [54], 'coli,': [55], 'IE': [56, 83, 100, 119], 'methylated': [58], 'by': [59, 70], 'Dam': [60], 'methylase': [61], '(IE': [62], 'ME': [63, 101, 120], ').': [64], 'This': [65, 136], 'methylation': [66], 'greatly': [67, 73], 'inhibits': [68], 'reduces': [74], 'ability': [76], 'facilitate': [80], 'defined': [84, 121], 'transposons.': [85, 135], 'Through': [86], 'use': [87], 'combinatorial': [90], 'random': [91], 'mutagenesis': [92], 'technique': [93], '(DNA': [94], 'shuffling),': [95], 'we': [96], 'have': [97], 'isolated': [98], 'an': [99], '-specific': [102], 'hyperactive': [103], 'form': [104], 'Tnp,': [106], 'sC7v.2.0,': [108], 'able': [111], 'promote': [113], 'high': [114], 'levels': [115, 132], 'transposons': [122], 'vivo': [124], 'vitro': [127], 'while': [128], 'functioning': [129], 'at': [130, 143], 'wild-type': [131], 'with': [133], 'OE': [134], 'protein': [137], 'critical': [140], 'glutamate-to-valine': [141], 'mutation': [142], 'amino': [144], 'acid': [145], '58': [146], 'responsible': [149], 'this': [151], 'change': [152], 'specificity.': [155]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2161052699', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2025-01-11T19:04:06.173234', 'created_date': '2016-06-24'}