Sex Steroids and the Construction and Conservation of the Adult Skeleton

Name: Work Video:
Duration: 3 min 30 s
B. Lawrence Riggs; Sundeep Khosla; L. Joseph Melton
{'id': 'https://openalex.org/W2160287478', 'doi': 'https://doi.org/10.1210/edrv.23.3.0465', 'title': 'Sex Steroids and the Construction and Conservation of the Adult Skeleton', 'display_name': 'Sex Steroids and the Construction and Conservation of the Adult Skeleton', 'publication_year': 2002, 'publication_date': '2002-06-01', 'ids': {'openalex': 'https://openalex.org/W2160287478', 'doi': 'https://doi.org/10.1210/edrv.23.3.0465', 'mag': '2160287478', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12050121'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/edrv.23.3.0465', 'pdf_url': 'https://academic.oup.com/edrv/article-pdf/23/3/279/8860311/edrv0279.pdf', 'source': {'id': 'https://openalex.org/S13493133', 'display_name': 'Endocrine Reviews', 'issn_l': '0163-769X', 'issn': ['0163-769X', '1945-7189'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/edrv/article-pdf/23/3/279/8860311/edrv0279.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108401950', 'display_name': 'B. Lawrence Riggs', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'B. Lawrence Riggs', 'raw_affiliation_strings': ['Division of Endocrinology and Metabolism (B.L.R., S.K., L.J.M.), Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905'], 'affiliations': [{'raw_affiliation_string': 'Division of Endocrinology and Metabolism (B.L.R., S.K., L.J.M.), Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027073303', 'display_name': 'Sundeep Khosla', 'orcid': 'https://orcid.org/0000-0002-2936-4372'}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sundeep Khosla', 'raw_affiliation_strings': ['Division of Endocrinology and Metabolism (B.L.R., S.K., L.J.M.), Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905'], 'affiliations': [{'raw_affiliation_string': 'Division of Endocrinology and Metabolism (B.L.R., S.K., L.J.M.), Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103443929', 'display_name': 'L. Joseph Melton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L. Joseph Melton', 'raw_affiliation_strings': ['Department of Internal Medicine, and Section of Clinical Epidemiology (L.J.M.), Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905', 'Division of Endocrinology and Metabolism (B.L.R., S.K., L.J.M.), Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, and Section of Clinical Epidemiology (L.J.M.), Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905', 'institution_ids': ['https://openalex.org/I1330342723']}, {'raw_affiliation_string': 'Division of Endocrinology and Metabolism (B.L.R., S.K., L.J.M.), Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905', 'institution_ids': ['https://openalex.org/I1330342723']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3400, 'currency': 'USD', 'value_usd': 3400, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 13.02, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1688, 'citation_normalized_percentile': {'value': 0.992537, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '23', 'issue': '3', 'first_page': '279', 'last_page': '302'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10071', 'display_name': 'Bone health and osteoporosis research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2732', 'display_name': 'Orthopedics and Sports Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10071', 'display_name': 'Bone health and osteoporosis research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2732', 'display_name': 'Orthopedics and Sports Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10277', 'display_name': 'Vitamin D Research Studies', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cancellous-bone', 'display_name': 'Cancellous bone', 'score': 0.62375426}, {'id': 'https://openalex.org/keywords/peak-bone-mass', 'display_name': 'Peak bone mass', 'score': 0.59696925}, {'id': 'https://openalex.org/keywords/skeleton', 'display_name': 'Skeleton (computer programming)', 'score': 0.5373994}, {'id': 'https://openalex.org/keywords/bone-remodeling', 'display_name': 'Bone remodeling', 'score': 0.52970386}, {'id': 'https://openalex.org/keywords/apposition', 'display_name': 'Apposition', 'score': 0.5001025}, {'id': 'https://openalex.org/keywords/osteopenia', 'display_name': 'Osteopenia', 'score': 0.41684255}], 'concepts': [{'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.83126926}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.79284936}, {'id': 'https://openalex.org/C2776350087', 'wikidata': 'https://www.wikidata.org/wiki/Q265868', 'display_name': 'Cancellous bone', 'level': 2, 'score': 0.62375426}, {'id': 'https://openalex.org/C2776541429', 'wikidata': 'https://www.wikidata.org/wiki/Q165328', 'display_name': 'Osteoporosis', 'level': 2, 'score': 0.61301893}, {'id': 'https://openalex.org/C2780712178', 'wikidata': 'https://www.wikidata.org/wiki/Q25326559', 'display_name': 'Peak bone mass', 'level': 4, 'score': 0.59696925}, {'id': 'https://openalex.org/C18969341', 'wikidata': 'https://www.wikidata.org/wiki/Q1169129', 'display_name': 'Skeleton (computer programming)', 'level': 2, 'score': 0.5373994}, {'id': 'https://openalex.org/C2778260815', 'wikidata': 'https://www.wikidata.org/wiki/Q917177', 'display_name': 'Osteoblast', 'level': 3, 'score': 0.5300431}, {'id': 'https://openalex.org/C170033053', 'wikidata': 'https://www.wikidata.org/wiki/Q952019', 'display_name': 'Bone remodeling', 'level': 2, 'score': 0.52970386}, {'id': 'https://openalex.org/C117866178', 'wikidata': 'https://www.wikidata.org/wiki/Q321056', 'display_name': 'Apposition', 'level': 2, 'score': 0.5001025}, {'id': 'https://openalex.org/C2781451080', 'wikidata': 'https://www.wikidata.org/wiki/Q265868', 'display_name': 'Cortical bone', 'level': 2, 'score': 0.47496578}, {'id': 'https://openalex.org/C2777164284', 'wikidata': 'https://www.wikidata.org/wiki/Q277954', 'display_name': 'Estrogen', 'level': 2, 'score': 0.45967203}, {'id': 'https://openalex.org/C519063684', 'wikidata': 'https://www.wikidata.org/wiki/Q706', 'display_name': 'Calcium', 'level': 2, 'score': 0.42738527}, {'id': 'https://openalex.org/C2777083390', 'wikidata': 'https://www.wikidata.org/wiki/Q1367706', 'display_name': 'Osteopenia', 'level': 4, 'score': 0.41684255}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3899022}, {'id': 'https://openalex.org/C2993253760', 'wikidata': 'https://www.wikidata.org/wiki/Q2304401', 'display_name': 'Bone mass', 'level': 3, 'score': 0.32615826}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.31908554}, {'id': 'https://openalex.org/C2776886416', 'wikidata': 'https://www.wikidata.org/wiki/Q4941567', 'display_name': 'Bone mineral', 'level': 3, 'score': 0.20071962}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.1987488}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001842', 'descriptor_name': 'Bone and Bones', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D012739', 'descriptor_name': 'Gonadal Steroid Hormones', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001846', 'descriptor_name': 'Bone Development', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001846', 'descriptor_name': 'Bone Development', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001842', 'descriptor_name': 'Bone and Bones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012739', 'descriptor_name': 'Gonadal Steroid Hormones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010024', 'descriptor_name': 'Osteoporosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010024', 'descriptor_name': 'Osteoporosis', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D015663', 'descriptor_name': 'Osteoporosis, Postmenopausal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015663', 'descriptor_name': 'Osteoporosis, Postmenopausal', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D012727', 'descriptor_name': 'Sex Characteristics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/edrv.23.3.0465', 'pdf_url': 'https://academic.oup.com/edrv/article-pdf/23/3/279/8860311/edrv0279.pdf', 'source': {'id': 'https://openalex.org/S13493133', 'display_name': 'Endocrine Reviews', 'issn_l': '0163-769X', 'issn': ['0163-769X', '1945-7189'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12050121', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/edrv.23.3.0465', 'pdf_url': 'https://academic.oup.com/edrv/article-pdf/23/3/279/8860311/edrv0279.pdf', 'source': {'id': 'https://openalex.org/S13493133', 'display_name': 'Endocrine Reviews', 'issn_l': '0163-769X', 'issn': ['0163-769X', '1945-7189'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 236, 'referenced_works': ['https://openalex.org/W1561293749', 'https://openalex.org/W162537503', 'https://openalex.org/W1907394035', 'https://openalex.org/W194572488', 'https://openalex.org/W1963699154', 'https://openalex.org/W1964555270', 'https://openalex.org/W1965429711', 'https://openalex.org/W1966125778', 'https://openalex.org/W1967010727', 'https://openalex.org/W1967625629', 'https://openalex.org/W1968506930', 'https://openalex.org/W1968635976', 'https://openalex.org/W1969027216', 'https://openalex.org/W1970787765', 'https://openalex.org/W1972672504', 'https://openalex.org/W1974973093', 'https://openalex.org/W1976209504', 'https://openalex.org/W1978813848', 'https://openalex.org/W1979344569', 'https://openalex.org/W1980227876', 'https://openalex.org/W1984683352', 'https://openalex.org/W1984804574', 'https://openalex.org/W1984941837', 'https://openalex.org/W1985184665', 'https://openalex.org/W1985605692', 'https://openalex.org/W1986506426', 'https://openalex.org/W1987910229', 'https://openalex.org/W1988289142', 'https://openalex.org/W1989048614', 'https://openalex.org/W1989051224', 'https://openalex.org/W1990034002', 'https://openalex.org/W1991455388', 'https://openalex.org/W1992348310', 'https://openalex.org/W1992865447', 'https://openalex.org/W1993231839', 'https://openalex.org/W1995053144', 'https://openalex.org/W1995112082', 'https://openalex.org/W1998293363', 'https://openalex.org/W1998488424', 'https://openalex.org/W1998674441', 'https://openalex.org/W2000980702', 'https://openalex.org/W2001532004', 'https://openalex.org/W2002097741', 'https://openalex.org/W2002453791', 'https://openalex.org/W2002676453', 'https://openalex.org/W2002748611', 'https://openalex.org/W2002924549', 'https://openalex.org/W2003326283', 'https://openalex.org/W2003743012', 'https://openalex.org/W2004236425', 'https://openalex.org/W2005204978', 'https://openalex.org/W2005395129', 'https://openalex.org/W2005669475', 'https://openalex.org/W2006145185', 'https://openalex.org/W2006646110', 'https://openalex.org/W2008698339', 'https://openalex.org/W2008973916', 'https://openalex.org/W2009110883', 'https://openalex.org/W2009451706', 'https://openalex.org/W2009664223', 'https://openalex.org/W2010663321', 'https://openalex.org/W2013729184', 'https://openalex.org/W2014480858', 'https://openalex.org/W2014492486', 'https://openalex.org/W2015178646', 'https://openalex.org/W2016222448', 'https://openalex.org/W2016674232', 'https://openalex.org/W2017356096', 'https://openalex.org/W2017552465', 'https://openalex.org/W2017730351', 'https://openalex.org/W2017945794', 'https://openalex.org/W2018245449', 'https://openalex.org/W2018316404', 'https://openalex.org/W2018376606', 'https://openalex.org/W2018602999', 'https://openalex.org/W2021163625', 'https://openalex.org/W2021571622', 'https://openalex.org/W2022693497', 'https://openalex.org/W2024355830', 'https://openalex.org/W2024901165', 'https://openalex.org/W2025597791', 'https://openalex.org/W2027361451', 'https://openalex.org/W2029728503', 'https://openalex.org/W2030218221', 'https://openalex.org/W2031293802', 'https://openalex.org/W2032031859', 'https://openalex.org/W2033113155', 'https://openalex.org/W2033767569', 'https://openalex.org/W2034196869', 'https://openalex.org/W2034227510', 'https://openalex.org/W2035364124', 'https://openalex.org/W2038050797', 'https://openalex.org/W2038830087', 'https://openalex.org/W2039342183', 'https://openalex.org/W2040395479', 'https://openalex.org/W2040818845', 'https://openalex.org/W2041591201', 'https://openalex.org/W2041939368', 'https://openalex.org/W2043144329', 'https://openalex.org/W2044054235', 'https://openalex.org/W2044451093', 'https://openalex.org/W2044753888', 'https://openalex.org/W2045206677', 'https://openalex.org/W2045673939', 'https://openalex.org/W2046431014', 'https://openalex.org/W2048925142', 'https://openalex.org/W2049160624', 'https://openalex.org/W2049293836', 'https://openalex.org/W2049309665', 'https://openalex.org/W2049392332', 'https://openalex.org/W2049716343', 'https://openalex.org/W2051947382', 'https://openalex.org/W2053664177', 'https://openalex.org/W2054267961', 'https://openalex.org/W2054734655', 'https://openalex.org/W2055504706', 'https://openalex.org/W2057346072', 'https://openalex.org/W2058056109', 'https://openalex.org/W2058207410', 'https://openalex.org/W2058273161', 'https://openalex.org/W2059050082', 'https://openalex.org/W2059913924', 'https://openalex.org/W2061644594', 'https://openalex.org/W2062229303', 'https://openalex.org/W2062705571', 'https://openalex.org/W2062729355', 'https://openalex.org/W2063048904', 'https://openalex.org/W2063518962', 'https://openalex.org/W2064282853', 'https://openalex.org/W2064797437', 'https://openalex.org/W2064891767', 'https://openalex.org/W2066062971', 'https://openalex.org/W2066314626', 'https://openalex.org/W2066570926', 'https://openalex.org/W2066988136', 'https://openalex.org/W2067420381', 'https://openalex.org/W2067456063', 'https://openalex.org/W2070469871', 'https://openalex.org/W2070656089', 'https://openalex.org/W2070784449', 'https://openalex.org/W2072050034', 'https://openalex.org/W2072231974', 'https://openalex.org/W2073353512', 'https://openalex.org/W2075992155', 'https://openalex.org/W2076067955', 'https://openalex.org/W2076440836', 'https://openalex.org/W2077163152', 'https://openalex.org/W2078223118', 'https://openalex.org/W2078406992', 'https://openalex.org/W2079088427', 'https://openalex.org/W2081627738', 'https://openalex.org/W2083197990', 'https://openalex.org/W2084535197', 'https://openalex.org/W2087317080', 'https://openalex.org/W2087407206', 'https://openalex.org/W2087513216', 'https://openalex.org/W2088946921', 'https://openalex.org/W2089605816', 'https://openalex.org/W2094838095', 'https://openalex.org/W2097950610', 'https://openalex.org/W2100217829', 'https://openalex.org/W2100578943', 'https://openalex.org/W2102024055', 'https://openalex.org/W2102385712', 'https://openalex.org/W2103523841', 'https://openalex.org/W2104841913', 'https://openalex.org/W2105609354', 'https://openalex.org/W2108626793', 'https://openalex.org/W2108734932', 'https://openalex.org/W2110993073', 'https://openalex.org/W2115932658', 'https://openalex.org/W2116271944', 'https://openalex.org/W2120122580', 'https://openalex.org/W2122802647', 'https://openalex.org/W2124998345', 'https://openalex.org/W2125284749', 'https://openalex.org/W2126602974', 'https://openalex.org/W2127529986', 'https://openalex.org/W2127604348', 'https://openalex.org/W2130499224', 'https://openalex.org/W2130523127', 'https://openalex.org/W2131609948', 'https://openalex.org/W2135087298', 'https://openalex.org/W2136261265', 'https://openalex.org/W2136672074', 'https://openalex.org/W2138560194', 'https://openalex.org/W2140086733', 'https://openalex.org/W2140592897', 'https://openalex.org/W2142820105', 'https://openalex.org/W2143202678', 'https://openalex.org/W2143589976', 'https://openalex.org/W2144000500', 'https://openalex.org/W2145605021', 'https://openalex.org/W2146408916', 'https://openalex.org/W2150036233', 'https://openalex.org/W2153210264', 'https://openalex.org/W2154012098', 'https://openalex.org/W2155622922', 'https://openalex.org/W2157009361', 'https://openalex.org/W2159190632', 'https://openalex.org/W2159837057', 'https://openalex.org/W2160721561', 'https://openalex.org/W2160929202', 'https://openalex.org/W2161074900', 'https://openalex.org/W2164019859', 'https://openalex.org/W2164279017', 'https://openalex.org/W2165750517', 'https://openalex.org/W2169670651', 'https://openalex.org/W2187452737', 'https://openalex.org/W2188702389', 'https://openalex.org/W2282680077', 'https://openalex.org/W2314110838', 'https://openalex.org/W2321613759', 'https://openalex.org/W2322274315', 'https://openalex.org/W2324075496', 'https://openalex.org/W2326289669', 'https://openalex.org/W2327465611', 'https://openalex.org/W2330758239', 'https://openalex.org/W2331313671', 'https://openalex.org/W2332300541', 'https://openalex.org/W2395956853', 'https://openalex.org/W2413976406', 'https://openalex.org/W2462972130', 'https://openalex.org/W262007002', 'https://openalex.org/W2985196030', 'https://openalex.org/W3025949784', 'https://openalex.org/W30326195', 'https://openalex.org/W4232934018', 'https://openalex.org/W4236513239', 'https://openalex.org/W4244164354', 'https://openalex.org/W4251529174', 'https://openalex.org/W4252543199', 'https://openalex.org/W4253938871', 'https://openalex.org/W4254343695', 'https://openalex.org/W4296492010', 'https://openalex.org/W98806924'], 'related_works': ['https://openalex.org/W4388065403', 'https://openalex.org/W3084300665', 'https://openalex.org/W2415555105', 'https://openalex.org/W2397935890', 'https://openalex.org/W2075499839', 'https://openalex.org/W2054992424', 'https://openalex.org/W2047511843', 'https://openalex.org/W2036279558', 'https://openalex.org/W2032724589', 'https://openalex.org/W2016741066'], 'abstract_inverted_index': {'Abstract': [0], 'Here': [1], 'we': [2], 'review': [3], 'and': [4, 28, 45, 54, 56, 61, 104, 182, 272], 'extend': [5], 'a': [6, 64, 149], 'new': [7], 'unitary': [8], 'model': [9], 'for': [10, 24, 79, 100, 295], 'the': [11, 21, 32, 80, 90, 101, 108, 128, 161, 164, 185, 189, 198, 219, 234, 260, 282, 304], 'pathophysiology': [12], 'of': [13, 35, 51, 82, 93, 107, 117, 134, 163, 168, 191, 200, 221, 236, 263, 285, 307], 'involutional': [14], 'osteoporosis': [15], 'that': [16, 71, 139, 153, 216, 240], 'identifies': [17], 'estrogen': [18], '(E)': [19], 'as': [20, 31], 'key': [22, 49], 'hormone': [23], 'maintaining': [25], 'bone': [26, 37, 85, 118, 137, 171, 193, 202, 245, 264, 287, 298, 309], 'mass': [27, 86], 'E': [29, 44, 76, 169, 177, 222, 252, 271, 280, 301], 'deficiency': [30, 302], 'major': [33, 283, 305], 'cause': [34], 'age-related': [36, 308], 'loss': [38, 138, 162, 194, 203, 220, 310], 'in': [39, 87, 179, 276, 311], 'both': [40, 43, 88, 180, 256, 267, 290, 312], 'sexes.': [41, 313], 'Also,': [42], 'testosterone': [46], '(T)': [47], 'are': [48, 293], 'regulators': [50], 'skeletal': [52, 73], 'growth': [53, 69], 'maturation,': [55], 'E,': [57], 'together': [58], 'with': [59, 148], 'GH': [60], 'IGF-I,': [62], 'initiate': [63], '3-': [65], 'to': [66, 145, 243, 251, 259], '4-yr': [67], 'pubertal': [68], 'spurt': [70], 'doubles': [72], 'mass.': [74], 'Although': [75, 266], 'is': [77, 195, 204, 210, 241, 281, 303], 'required': [78, 242], 'attainment': [81], 'maximal': [83], 'peak': [84, 297], 'sexes,': [89], 'additional': [91], 'action': [92, 174], 'T': [94, 274], 'on': [95, 170, 224], 'stimulating': [96], 'periosteal': [97], 'apposition': [98], 'accounts': [99], 'larger': [102], 'size': [103], 'thicker': [105], 'cortices': [106], 'adult': [109], 'male': [110], 'skeleton.': [111], 'Aging': [112], 'women': [113], 'undergo': [114, 123], 'two': [115], 'phases': [116], 'loss,': [119], 'whereas': [120], 'aging': [121, 277], 'men': [122], 'only': [124], 'one.': [125], 'In': [126, 184], 'women,': [127], 'menopause': [129], 'initiates': [130], 'an': [131, 173], 'accelerated': [132, 157], 'phase': [133, 152, 158, 209, 262], 'predominantly': [135], 'cancellous': [136, 192], 'declines': [140], 'rapidly': [141], 'over': [142], '4–8': [143], 'yr': [144], 'become': [146], 'asymptotic': [147], 'subsequent': [150], 'slow': [151, 187, 261], 'continues': [154], 'indefinitely.': [155], 'The': [156, 228], 'results': [159, 217], 'from': [160, 218], 'direct': [165], 'restraining': [166], 'effects': [167], 'turnover,': [172], 'mediated': [175, 211], 'by': [176, 213], 'receptors': [178], 'osteoblasts': [181], 'osteoclasts.': [183], 'ensuing': [186], 'phase,': [188], 'rate': [190, 199], 'reduced,': [196], 'but': [197, 300], 'cortical': [201], 'unchanged': [205], 'or': [206, 255], 'increased.': [207], 'This': [208], 'largely': [212], 'secondary': [214], 'hyperparathyroidism': [215], 'actions': [223], 'extraskeletal': [225], 'calcium': [226, 231, 238], 'metabolism.': [227], 'resultant': [229], 'external': [230], 'losses': [232], 'increase': [233], 'level': [235], 'dietary': [237], 'intake': [239], 'maintain': [244], 'balance.': [246], 'Impaired': [247], 'osteoblast': [248], 'function': [249], 'due': [250], 'deficiency,': [253], 'aging,': [254], 'also': [257], 'contributes': [258], 'loss.': [265, 288], 'serum': [268], 'bioavailable': [269], '(Bio)': [270], 'Bio': [273, 279], 'decline': [275], 'men,': [278], 'predictor': [284], 'their': [286], 'Thus,': [289], 'sex': [291], 'steroids': [292], 'important': [294], 'developing': [296], 'mass,': [299], 'determinant': [306]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2160287478', 'counts_by_year': [{'year': 2024, 'cited_by_count': 41}, {'year': 2023, 'cited_by_count': 48}, {'year': 2022, 'cited_by_count': 55}, {'year': 2021, 'cited_by_count': 53}, {'year': 2020, 'cited_by_count': 60}, {'year': 2019, 'cited_by_count': 51}, {'year': 2018, 'cited_by_count': 63}, {'year': 2017, 'cited_by_count': 57}, {'year': 2016, 'cited_by_count': 57}, {'year': 2015, 'cited_by_count': 54}, {'year': 2014, 'cited_by_count': 92}, {'year': 2013, 'cited_by_count': 113}, {'year': 2012, 'cited_by_count': 105}], 'updated_date': '2024-12-20T03:06:25.979006', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
