Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2160266371', 'doi': 'https://doi.org/10.1634/stemcells.2004-0279', 'title': 'Activin A Maintains Pluripotency of Human Embryonic Stem Cells in the Absence of Feeder Layers', 'display_name': 'Activin A Maintains Pluripotency of Human Embryonic Stem Cells in the Absence of Feeder Layers', 'publication_year': 2005, 'publication_date': '2005-04-01', 'ids': {'openalex': 'https://openalex.org/W2160266371', 'doi': 'https://doi.org/10.1634/stemcells.2004-0279', 'mag': '2160266371', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15790770'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1634/stemcells.2004-0279', 'pdf_url': 'https://academic.oup.com/stmcls/article-pdf/23/4/489/41029274/stmcls_23_4_489.pdf', 'source': {'id': 'https://openalex.org/S65139510', 'display_name': 'Stem Cells', 'issn_l': '1066-5099', 'issn': ['1066-5099', '1549-4918'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/stmcls/article-pdf/23/4/489/41029274/stmcls_23_4_489.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061168518', 'display_name': 'Gillian M. Beattie', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I70076703', 'display_name': 'Whittier College', 'ror': 'https://ror.org/04z664d45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I70076703']}, {'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gillian M. Beattie', 'raw_affiliation_strings': ['Whittier Institute, Department of Pediatrics, University of California, San Diego, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Whittier Institute, Department of Pediatrics, University of California, San Diego, California, USA', 'institution_ids': ['https://openalex.org/I70076703', 'https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088810037', 'display_name': 'Ana D. Lopez', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I70076703', 'display_name': 'Whittier College', 'ror': 'https://ror.org/04z664d45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I70076703']}, {'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ana D. Lopez', 'raw_affiliation_strings': ['Whittier Institute, Department of Pediatrics, University of California, San Diego, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Whittier Institute, Department of Pediatrics, University of California, San Diego, California, USA', 'institution_ids': ['https://openalex.org/I70076703', 'https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016326565', 'display_name': 'Nathan Bucay', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I70076703', 'display_name': 'Whittier College', 'ror': 'https://ror.org/04z664d45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I70076703']}, {'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nathan Bucay', 'raw_affiliation_strings': ['Whittier Institute, Department of Pediatrics, University of California, San Diego, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Whittier Institute, Department of Pediatrics, University of California, San Diego, California, USA', 'institution_ids': ['https://openalex.org/I70076703', 'https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028277308', 'display_name': 'Andrew Hinton', 'orcid': 'https://orcid.org/0009-0000-2744-9308'}, 'institutions': [{'id': 'https://openalex.org/I70076703', 'display_name': 'Whittier College', 'ror': 'https://ror.org/04z664d45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I70076703']}, {'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew Hinton', 'raw_affiliation_strings': ['Whittier Institute, Department of Pediatrics, University of California, San Diego, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Whittier Institute, Department of Pediatrics, University of California, San Diego, California, USA', 'institution_ids': ['https://openalex.org/I70076703', 'https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038754832', 'display_name': 'Meri T. Firpo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Meri T. Firpo', 'raw_affiliation_strings': ['Stem Cell Research, Department of Obstetrics, Gynecology and Reproductive Science, University of California, San Francisco, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Stem Cell Research, Department of Obstetrics, Gynecology and Reproductive Science, University of California, San Francisco, California, USA', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059314538', 'display_name': 'Charles C. King', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I70076703', 'display_name': 'Whittier College', 'ror': 'https://ror.org/04z664d45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I70076703']}, {'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Charles C. King', 'raw_affiliation_strings': ['Whittier Institute, Department of Pediatrics, University of California, San Diego, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Whittier Institute, Department of Pediatrics, University of California, San Diego, California, USA', 'institution_ids': ['https://openalex.org/I70076703', 'https://openalex.org/I36258959']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5090226966', 'display_name': 'Alberto Hayek', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I70076703', 'display_name': 'Whittier College', 'ror': 'https://ror.org/04z664d45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I70076703']}, {'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Alberto Hayek', 'raw_affiliation_strings': ['Whittier Institute, Department of Pediatrics, University of California, San Diego, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Whittier Institute, Department of Pediatrics, University of California, San Diego, California, USA', 'institution_ids': ['https://openalex.org/I70076703', 'https://openalex.org/I36258959']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5090226966'], 'corresponding_institution_ids': ['https://openalex.org/I70076703', 'https://openalex.org/I36258959'], 'apc_list': {'value': 4140, 'currency': 'USD', 'value_usd': 4140, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 19.369, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 490, 'citation_normalized_percentile': {'value': 0.99998, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '23', 'issue': '4', 'first_page': '489', 'last_page': '495'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10505', 'display_name': 'Induction and Differentiation of Pluripotent Stem Cells', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10505', 'display_name': 'Induction and Differentiation of Pluripotent Stem Cells', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12140', 'display_name': 'Molecular Mechanisms of Kidney Development and Disease', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/homeobox-protein-nanog', 'display_name': 'Homeobox protein NANOG', 'score': 0.8456551}, {'id': 'https://openalex.org/keywords/kosr', 'display_name': 'KOSR', 'score': 0.7772452}, {'id': 'https://openalex.org/keywords/rex1', 'display_name': 'Rex1', 'score': 0.53598654}, {'id': 'https://openalex.org/keywords/embryonic-stem-cells', 'display_name': 'Embryonic Stem Cells', 'score': 0.500931}, {'id': 'https://openalex.org/keywords/nanog-homeobox-protein', 'display_name': 'Nanog Homeobox Protein', 'score': 0.47743735}, {'id': 'https://openalex.org/keywords/embryoid-body', 'display_name': 'Embryoid body', 'score': 0.4623998}], 'concepts': [{'id': 'https://openalex.org/C145103041', 'wikidata': 'https://www.wikidata.org/wiki/Q1151519', 'display_name': 'Embryonic stem cell', 'level': 3, 'score': 0.8778622}, {'id': 'https://openalex.org/C207701140', 'wikidata': 'https://www.wikidata.org/wiki/Q420522', 'display_name': 'Homeobox protein NANOG', 'level': 5, 'score': 0.8456551}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8345797}, {'id': 'https://openalex.org/C23416140', 'wikidata': 'https://www.wikidata.org/wiki/Q6335239', 'display_name': 'KOSR', 'level': 5, 'score': 0.7772452}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.7466091}, {'id': 'https://openalex.org/C27284151', 'wikidata': 'https://www.wikidata.org/wiki/Q6534502', 'display_name': 'Leukemia inhibitory factor', 'level': 4, 'score': 0.6453456}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.6106478}, {'id': 'https://openalex.org/C207168726', 'wikidata': 'https://www.wikidata.org/wiki/Q18050439', 'display_name': 'Rex1', 'level': 5, 'score': 0.53598654}, {'id': 'https://openalex.org/C107459253', 'wikidata': 'https://www.wikidata.org/wiki/Q674925', 'display_name': 'Induced pluripotent stem cell', 'level': 4, 'score': 0.5096812}, {'id': 'https://openalex.org/C2908926650', 'wikidata': 'https://www.wikidata.org/wiki/Q420522', 'display_name': 'Nanog Homeobox Protein', 'level': 5, 'score': 0.47743735}, {'id': 'https://openalex.org/C143948831', 'wikidata': 'https://www.wikidata.org/wiki/Q3384920', 'display_name': 'Embryoid body', 'level': 5, 'score': 0.4623998}, {'id': 'https://openalex.org/C148738053', 'wikidata': 'https://www.wikidata.org/wiki/Q210861', 'display_name': 'Cellular differentiation', 'level': 3, 'score': 0.4343336}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.11861825}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D028341', 'descriptor_name': 'Activins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D028322', 'descriptor_name': 'Inhibin-beta Subunits', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D039904', 'descriptor_name': 'Pluripotent Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D028341', 'descriptor_name': 'Activins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000954', 'descriptor_name': 'Antigens, Surface', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018929', 'descriptor_name': 'Cell Culture Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003470', 'descriptor_name': 'Culture Media', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051523', 'descriptor_name': 'Fibroblast Growth Factor 7', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051523', 'descriptor_name': 'Fibroblast Growth Factor 7', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D028322', 'descriptor_name': 'Inhibin-beta Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007621', 'descriptor_name': 'Karyotyping', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007797', 'descriptor_name': 'Laminin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007797', 'descriptor_name': 'Laminin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071317', 'descriptor_name': 'Nanog Homeobox Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009536', 'descriptor_name': 'Niacinamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009536', 'descriptor_name': 'Niacinamide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050814', 'descriptor_name': 'Octamer Transcription Factor-3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050814', 'descriptor_name': 'Octamer Transcription Factor-3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D039904', 'descriptor_name': 'Pluripotent Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D039904', 'descriptor_name': 'Pluripotent Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011509', 'descriptor_name': 'Proteoglycans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013724', 'descriptor_name': 'Teratoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013724', 'descriptor_name': 'Teratoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1634/stemcells.2004-0279', 'pdf_url': 'https://academic.oup.com/stmcls/article-pdf/23/4/489/41029274/stmcls_23_4_489.pdf', 'source': {'id': 'https://openalex.org/S65139510', 'display_name': 'Stem Cells', 'issn_l': '1066-5099', 'issn': ['1066-5099', '1549-4918'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15790770', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1634/stemcells.2004-0279', 'pdf_url': 'https://academic.oup.com/stmcls/article-pdf/23/4/489/41029274/stmcls_23_4_489.pdf', 'source': {'id': 'https://openalex.org/S65139510', 'display_name': 'Stem Cells', 'issn_l': '1066-5099', 'issn': ['1066-5099', '1549-4918'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W153705940', 'https://openalex.org/W1599568627', 'https://openalex.org/W1701092691', 'https://openalex.org/W1965355602', 'https://openalex.org/W1988865085', 'https://openalex.org/W1992949513', 'https://openalex.org/W2005432188', 'https://openalex.org/W2014726972', 'https://openalex.org/W2022396968', 'https://openalex.org/W2037388456', 'https://openalex.org/W2037917812', 'https://openalex.org/W2045858906', 'https://openalex.org/W2055435288', 'https://openalex.org/W2056089399', 'https://openalex.org/W2060889469', 'https://openalex.org/W2086943348', 'https://openalex.org/W2089426706', 'https://openalex.org/W2094557730', 'https://openalex.org/W2098109070', 'https://openalex.org/W2101556559', 'https://openalex.org/W2112466465', 'https://openalex.org/W2120297737', 'https://openalex.org/W2133179274', 'https://openalex.org/W2138442302', 'https://openalex.org/W2151487778', 'https://openalex.org/W2154601080', 'https://openalex.org/W2283752399', 'https://openalex.org/W4243347737', 'https://openalex.org/W4251215061'], 'related_works': ['https://openalex.org/W4254787690', 'https://openalex.org/W2978918678', 'https://openalex.org/W2411684336', 'https://openalex.org/W2193785490', 'https://openalex.org/W2124566253', 'https://openalex.org/W2076549991', 'https://openalex.org/W2055759147', 'https://openalex.org/W2031687138', 'https://openalex.org/W2001423159', 'https://openalex.org/W1978560791'], 'abstract_inverted_index': {'To': [0], 'date,': [1], 'all': [2], 'human': [3, 59], 'embryonic': [4, 40, 71], 'stem': [5, 41], 'cells': [6], '(hESCs)': [7], 'available': [8], 'for': [9, 54, 92, 98], 'research': [10], 'require': [11], 'unidentified': [12], 'soluble': [13], 'factors': [14], 'secreted': [15, 68], 'from': [16, 103], 'feeder': [17, 72, 99], 'layers': [18, 73], 'to': [19, 35], 'maintain': [20, 36], 'the': [21, 48, 89, 96, 129], 'undifferentiated': [22, 90, 116], 'state': [23, 91], 'and': [24, 56, 75, 113, 121, 123], 'pluripotency.': [25], 'Activation': [26], 'of': [27, 50, 85, 115, 133], 'STAT3': [28, 106], 'by': [29, 69, 128], 'leukemia': [30], 'inhibitory': [31], 'factor': [32], 'is': [33, 67, 83], 'required': [34], '"stemness"': [37], 'in': [38, 45, 58, 88, 130], 'mouse': [39, 70], 'cells,': [42, 117], 'but': [43], 'not': [44], 'hESCs,': [46], 'suggesting': [47], 'existence': [49], 'alternate': [51], 'signaling': [52], 'pathways': [53], 'self‐renewal': [55], 'pluripotency': [57], 'cells.': [60], 'Here': [61], 'we': [62], 'show': [63], 'that': [64, 76], 'activin': [65, 81], 'A': [66, 82], '(mEFs)': [74], 'culture': [77], 'medium': [78, 102], 'enriched': [79], 'with': [80], 'capable': [84], 'maintaining': [86], 'hESCs': [87, 108], '>20': [93], 'passages': [94], 'without': [95], 'need': [97], 'layers,': [100], 'conditioned': [101], 'mEFs,': [104], 'or': [105], 'activation.': [107], 'retained': [109], 'both': [110], 'normal': [111], 'karyotype': [112], 'markers': [114], 'including': [118], 'Oct‐4,': [119], 'nanog,': [120], 'TRA‐1‐60': [122], 'remained': [124], 'pluripotent,': [125], 'as': [126], 'shown': [127], 'vivo': [131], 'formation': [132], 'teratomas.': [134]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2160266371', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 17}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 38}, {'year': 2012, 'cited_by_count': 29}], 'updated_date': '2024-09-16T12:33:55.697547', 'created_date': '2016-06-24'}