Publication Information

{'id': 'https://openalex.org/W2160172641', 'doi': 'https://doi.org/10.2337/diabetes.49.12.2196', 'title': 'A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls.', 'display_name': 'A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls.', 'publication_year': 2000, 'publication_date': '2000-12-01', 'ids': {'openalex': 'https://openalex.org/W2160172641', 'doi': 'https://doi.org/10.2337/diabetes.49.12.2196', 'mag': '2160172641', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11118025'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2337/diabetes.49.12.2196', 'pdf_url': 'https://diabetesjournals.org/diabetes/article-pdf/49/12/2196/365984/11118025.pdf', 'source': {'id': 'https://openalex.org/S129060628', 'display_name': 'Diabetes', 'issn_l': '0012-1797', 'issn': ['0012-1797', '1939-327X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320274', 'host_organization_name': 'American Diabetes Association', 'host_organization_lineage': ['https://openalex.org/P4310320274'], 'host_organization_lineage_names': ['American Diabetes Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://diabetesjournals.org/diabetes/article-pdf/49/12/2196/365984/11118025.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5019073784', 'display_name': 'Catherine Le Stunff', 'orcid': 'https://orcid.org/0000-0001-8419-0451'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'C Le Stunff', 'raw_affiliation_strings': ['Unité 342 of the Institut National de la Santé et de la Recherche Médicale and the Pediatric Endocrinology Department, René Descartes University, Paris, France.'], 'affiliations': [{'raw_affiliation_string': 'Unité 342 of the Institut National de la Santé et de la Recherche Médicale and the Pediatric Endocrinology Department, René Descartes University, Paris, France.', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I204730241']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041286423', 'display_name': 'Christine Le Bihan-Benjamin', 'orcid': 'https://orcid.org/0000-0002-1868-9358'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'C Le Bihan', 'raw_affiliation_strings': ['Unité 342 of the Institut National de la Santé et de la Recherche Médicale and the Pediatric Endocrinology Department, René Descartes University, Paris, France.'], 'affiliations': [{'raw_affiliation_string': 'Unité 342 of the Institut National de la Santé et de la Recherche Médicale and the Pediatric Endocrinology Department, René Descartes University, Paris, France.', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I204730241']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077225971', 'display_name': 'Nicholas J. Schork', 'orcid': 'https://orcid.org/0000-0003-0920-5013'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'N J Schork', 'raw_affiliation_strings': ['Unité 342 of the Institut National de la Santé et de la Recherche Médicale and the Pediatric Endocrinology Department, René Descartes University, Paris, France.'], 'affiliations': [{'raw_affiliation_string': 'Unité 342 of the Institut National de la Santé et de la Recherche Médicale and the Pediatric Endocrinology Department, René Descartes University, Paris, France.', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I204730241']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111770252', 'display_name': 'Pierre-François Bougnères', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204730241', 'display_name': 'Université Paris Cité', 'ror': 'https://ror.org/05f82e368', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I204730241']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'P Bougnères', 'raw_affiliation_strings': ['Unité 342 of the Institut National de la Santé et de la Recherche Médicale and the Pediatric Endocrinology Department, René Descartes University, Paris, France.'], 'affiliations': [{'raw_affiliation_string': 'Unité 342 of the Institut National de la Santé et de la Recherche Médicale and the Pediatric Endocrinology Department, René Descartes University, Paris, France.', 'institution_ids': ['https://openalex.org/I204730241', 'https://openalex.org/I154526488']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.739, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 145, 'citation_normalized_percentile': {'value': 0.931869, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '49', 'issue': '12', 'first_page': '2196', 'last_page': '2200'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10489', 'display_name': 'Regulation of Appetite and Obesity', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10489', 'display_name': 'Regulation of Appetite and Obesity', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11584', 'display_name': 'Biochemical Analysis and Sensing Techniques', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9861, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mendelian-inheritance', 'display_name': 'Mendelian inheritance', 'score': 0.4678232}], 'concepts': [{'id': 'https://openalex.org/C2780613262', 'wikidata': 'https://www.wikidata.org/wiki/Q223739', 'display_name': 'Leptin', 'level': 3, 'score': 0.96385825}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.7507671}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.72460693}, {'id': 'https://openalex.org/C511355011', 'wikidata': 'https://www.wikidata.org/wiki/Q12174', 'display_name': 'Obesity', 'level': 2, 'score': 0.6338389}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.5943763}, {'id': 'https://openalex.org/C153209595', 'wikidata': 'https://www.wikidata.org/wiki/Q501128', 'display_name': 'Single-nucleotide polymorphism', 'level': 4, 'score': 0.5261835}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.51761806}, {'id': 'https://openalex.org/C175783326', 'wikidata': 'https://www.wikidata.org/wiki/Q185055', 'display_name': 'Mendelian inheritance', 'level': 3, 'score': 0.4678232}, {'id': 'https://openalex.org/C2780221984', 'wikidata': 'https://www.wikidata.org/wiki/Q131191', 'display_name': 'Body mass index', 'level': 2, 'score': 0.4484055}, {'id': 'https://openalex.org/C194832188', 'wikidata': 'https://www.wikidata.org/wiki/Q2638593', 'display_name': 'Adipokine', 'level': 4, 'score': 0.41170275}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.39498764}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.37475896}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.2833602}], 'mesh': [{'descriptor_ui': 'D000273', 'descriptor_name': 'Adipose Tissue', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D014644', 'descriptor_name': 'Genetic Variation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020738', 'descriptor_name': 'Leptin', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D020738', 'descriptor_name': 'Leptin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009765', 'descriptor_name': 'Obesity', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009765', 'descriptor_name': 'Obesity', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000273', 'descriptor_name': 'Adipose Tissue', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002675', 'descriptor_name': 'Child, Preschool', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015331', 'descriptor_name': 'Cohort Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005838', 'descriptor_name': 'Genotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020738', 'descriptor_name': 'Leptin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009765', 'descriptor_name': 'Obesity', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009765', 'descriptor_name': 'Obesity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009929', 'descriptor_name': 'Organ Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2337/diabetes.49.12.2196', 'pdf_url': 'https://diabetesjournals.org/diabetes/article-pdf/49/12/2196/365984/11118025.pdf', 'source': {'id': 'https://openalex.org/S129060628', 'display_name': 'Diabetes', 'issn_l': '0012-1797', 'issn': ['0012-1797', '1939-327X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320274', 'host_organization_name': 'American Diabetes Association', 'host_organization_lineage': ['https://openalex.org/P4310320274'], 'host_organization_lineage_names': ['American Diabetes Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11118025', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2337/diabetes.49.12.2196', 'pdf_url': 'https://diabetesjournals.org/diabetes/article-pdf/49/12/2196/365984/11118025.pdf', 'source': {'id': 'https://openalex.org/S129060628', 'display_name': 'Diabetes', 'issn_l': '0012-1797', 'issn': ['0012-1797', '1939-327X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320274', 'host_organization_name': 'American Diabetes Association', 'host_organization_lineage': ['https://openalex.org/P4310320274'], 'host_organization_lineage_names': ['American Diabetes Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.68}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1512875938', 'https://openalex.org/W1594976448', 'https://openalex.org/W1631449371', 'https://openalex.org/W1964357455', 'https://openalex.org/W1970334028', 'https://openalex.org/W1988896890', 'https://openalex.org/W1996713062', 'https://openalex.org/W1999313641', 'https://openalex.org/W2000934244', 'https://openalex.org/W2021052947', 'https://openalex.org/W2025638325', 'https://openalex.org/W2034021000', 'https://openalex.org/W2036605171', 'https://openalex.org/W2042316959', 'https://openalex.org/W2051138087', 'https://openalex.org/W2053426841', 'https://openalex.org/W2060291314', 'https://openalex.org/W2060313221', 'https://openalex.org/W2078769875', 'https://openalex.org/W2095930296', 'https://openalex.org/W2125510262', 'https://openalex.org/W2134279034', 'https://openalex.org/W2149754976', 'https://openalex.org/W2161944247', 'https://openalex.org/W2162055842', 'https://openalex.org/W2321726532', 'https://openalex.org/W2334337188', 'https://openalex.org/W4247307679', 'https://openalex.org/W4249148858', 'https://openalex.org/W4251240516', 'https://openalex.org/W4252033234', 'https://openalex.org/W4255139035'], 'related_works': ['https://openalex.org/W4235128290', 'https://openalex.org/W2899163261', 'https://openalex.org/W2155585482', 'https://openalex.org/W2114784446', 'https://openalex.org/W2113382445', 'https://openalex.org/W2108749909', 'https://openalex.org/W2040058335', 'https://openalex.org/W2034800706', 'https://openalex.org/W2001652059', 'https://openalex.org/W1967968809'], 'abstract_inverted_index': {'Mutations': [0], 'in': [1, 13, 23, 31, 68, 79, 101, 149, 167], 'the': [2, 24, 94, 102, 128, 140, 150, 161, 169, 176], 'leptin': [3, 28, 47, 59, 95, 106, 117, 137, 162, 178], 'gene': [4, 29, 96, 163], 'lead': [5], 'to': [6, 41, 49, 72, 160, 209, 212], 'rare': [7], 'obese': [8, 38, 85, 173], 'syndromes': [9], 'of': [10, 27, 45, 58, 84, 93, 111, 153, 172, 184, 191], 'Mendelian': [11], 'inheritance': [12], 'humans': [14], 'and': [15, 107, 194], 'rodents.': [16], 'However,': [17], 'no': [18], 'relevant': [19], 'mutations': [20], 'are': [21], 'found': [22], 'coding': [25], 'region': [26], 'DNA': [30], 'patients': [32, 39], 'with': [33, 53, 99, 127, 142, 201], 'common': [34], 'multifactorial': [35], 'obesity.': [36], 'These': [37], 'tend': [40], 'have': [42, 114, 133], 'an': [43, 202], 'elevation': [44], 'serum': [46, 105], 'proportional': [48], 'their': [50, 121], 'adiposity': [51, 113], 'but': [52], 'a': [54, 62, 89, 181, 198], 'rather': [55], 'wide': [56], 'dispersion': [57], 'levels': [60, 138], 'for': [61, 180], 'given': [63, 182], 'body': [64, 108, 185], 'fat': [65], 'content,': [66], 'which': [67], 'part': [69], 'is': [70, 97, 206], 'attributable': [71], 'sexual': [73], 'dimorphism.': [74], 'The': [75], 'current': [76], 'study,': [77], 'performed': [78], 'two': [80], 'independent': [81], 'Caucasian': [82], 'cohorts': [83], 'girls,': [86], 'shows': [87], 'that': [88], 'frequent': [90], 'promoter': [91], 'variant': [92], 'associated': [98], 'changes': [100], 'relationship': [103], 'between': [104], 'fatness.': [109], 'Girls': [110, 126], 'comparable': [112], 'different': [115], 'circulating': [116, 177], 'levels,': [118], 'depending': [119], 'on': [120], 'genotype': [122, 132], 'at': [123], 'this': [124, 213], 'locus.': [125], '-/-': [129], 'Lep': [130], '-2,549': [131], '25%': [134], 'lower': [135], 'mean': [136], 'than': [139], 'girls': [141], 'other': [143], 'genotypes,': [144], 'as': [145], 'reflected': [146], 'by': [147], 'differences': [148], 'regression': [151], 'slopes': [152], 'leptin-to-fat': [154], 'mass.': [155], 'Therefore,': [156], 'genetic': [157], 'factors': [158], 'related': [159], 'may': [164, 189], 'be': [165, 190], 'important': [166], 'defining': [168], 'set': [170], 'point': [171], 'individuals': [174], '(i.e.,': [175], 'level': [179], 'degree': [183], 'fatness).': [186], 'This': [187], 'definition': [188], 'both': [192], 'physiological': [193], 'therapeutic': [195], 'relevance,': [196], 'although': [197], 'phenotypic': [199], 'association': [200], 'individual': [203], 'single-nucleotide': [204], 'polymorphism': [205], 'not': [207], 'sufficient': [208], 'assign': [210], 'function': [211], 'particular': [214], 'nucleotide': [215], 'site.': [216]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2160172641', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-10T06:54:33.636097', 'created_date': '2016-06-24'}