Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2160104373', 'doi': 'https://doi.org/10.1093/jac/37.2.209', 'title': 'The comparative efficacy and safety of teicoplanin and vancomycin', 'display_name': 'The comparative efficacy and safety of teicoplanin and vancomycin', 'publication_year': 1996, 'publication_date': '1996-01-01', 'ids': {'openalex': 'https://openalex.org/W2160104373', 'doi': 'https://doi.org/10.1093/jac/37.2.209', 'mag': '2160104373', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8707731'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jac/37.2.209', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.1093/jac/37.2.209', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5019018532', 'display_name': 'Marsha Wood', 'orcid': 'https://orcid.org/0000-0003-3933-9928'}, 'institutions': [{'id': 'https://openalex.org/I4210104666', 'display_name': 'Heartlands Hospital', 'ror': 'https://ror.org/01bd5gh54', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799726393', 'https://openalex.org/I4210104666']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'M J Wood', 'raw_affiliation_strings': ['Department of Infection and Tropical Medicine, Birmingham Heartlands Hospital, UK.'], 'affiliations': [{'raw_affiliation_string': 'Department of Infection and Tropical Medicine, Birmingham Heartlands Hospital, UK.', 'institution_ids': ['https://openalex.org/I4210104666']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5019018532'], 'corresponding_institution_ids': ['https://openalex.org/I4210104666'], 'apc_list': {'value': 2627, 'currency': 'GBP', 'value_usd': 3222, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.238, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 233, 'citation_normalized_percentile': {'value': 0.946494, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '37', 'issue': '2', 'first_page': '209', 'last_page': '222'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10195', 'display_name': 'Antimicrobial Resistance in Staphylococcus', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10195', 'display_name': 'Antimicrobial Resistance in Staphylococcus', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11153', 'display_name': 'Streptococcal Infections and Treatments', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12167', 'display_name': 'Bacterial Identification and Susceptibility Testing', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/teicoplanin', 'display_name': 'Teicoplanin', 'score': 0.98641175}, {'id': 'https://openalex.org/keywords/tolerability', 'display_name': 'Tolerability', 'score': 0.64838195}, {'id': 'https://openalex.org/keywords/glycopeptide-antibiotic', 'display_name': 'Glycopeptide antibiotic', 'score': 0.55320525}], 'concepts': [{'id': 'https://openalex.org/C2776703206', 'wikidata': 'https://www.wikidata.org/wiki/Q2731762', 'display_name': 'Teicoplanin', 'level': 5, 'score': 0.98641175}, {'id': 'https://openalex.org/C2778980435', 'wikidata': 'https://www.wikidata.org/wiki/Q424027', 'display_name': 'Vancomycin', 'level': 4, 'score': 0.872156}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.77876437}, {'id': 'https://openalex.org/C2778375690', 'wikidata': 'https://www.wikidata.org/wiki/Q7814214', 'display_name': 'Tolerability', 'level': 3, 'score': 0.64838195}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.63066024}, {'id': 'https://openalex.org/C2779390152', 'wikidata': 'https://www.wikidata.org/wiki/Q2293474', 'display_name': 'Glycopeptide antibiotic', 'level': 5, 'score': 0.55320525}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.47982073}, {'id': 'https://openalex.org/C137610392', 'wikidata': 'https://www.wikidata.org/wiki/Q2425020', 'display_name': 'Glycopeptide', 'level': 3, 'score': 0.43707508}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.32341182}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3002252}, {'id': 'https://openalex.org/C2779489039', 'wikidata': 'https://www.wikidata.org/wiki/Q188121', 'display_name': 'Staphylococcus aureus', 'level': 3, 'score': 0.21923187}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.17623106}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.08064398}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D017334', 'descriptor_name': 'Teicoplanin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D014640', 'descriptor_name': 'Vancomycin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015201', 'descriptor_name': 'Meta-Analysis as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016032', 'descriptor_name': 'Randomized Controlled Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013223', 'descriptor_name': 'Statistics as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017334', 'descriptor_name': 'Teicoplanin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017334', 'descriptor_name': 'Teicoplanin', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D014640', 'descriptor_name': 'Vancomycin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014640', 'descriptor_name': 'Vancomycin', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jac/37.2.209', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8707731', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jac/37.2.209', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.72, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W162736629', 'https://openalex.org/W1966746742', 'https://openalex.org/W1968518177', 'https://openalex.org/W1974519862', 'https://openalex.org/W1979341424', 'https://openalex.org/W1981169980', 'https://openalex.org/W2001101162', 'https://openalex.org/W2001650311', 'https://openalex.org/W2002699557', 'https://openalex.org/W2006334040', 'https://openalex.org/W2023518339', 'https://openalex.org/W2036516946', 'https://openalex.org/W2052113212', 'https://openalex.org/W2065659219', 'https://openalex.org/W2065798273', 'https://openalex.org/W2070342870', 'https://openalex.org/W2074986127', 'https://openalex.org/W2106050933', 'https://openalex.org/W2110459621', 'https://openalex.org/W2126520713', 'https://openalex.org/W2142289373'], 'related_works': ['https://openalex.org/W4200434045', 'https://openalex.org/W3216055888', 'https://openalex.org/W2969094441', 'https://openalex.org/W2184058138', 'https://openalex.org/W2168651392', 'https://openalex.org/W2112762994', 'https://openalex.org/W2087286378', 'https://openalex.org/W2072110049', 'https://openalex.org/W2056392770', 'https://openalex.org/W1972298183'], 'abstract_inverted_index': {'Glycopeptide': [0], 'antibiotics,': [1], 'such': [2, 202], 'as': [3, 63, 190, 192, 203], 'teicoplanin': [4, 22, 80, 107, 165, 188], 'and': [5, 17, 21, 44, 71, 73, 104, 108, 194, 209], 'vancomycin,': [6, 58], 'are': [7, 23, 75, 175], 'active': [8], 'against': [9], 'staphylococci': [10], '(including': [11], 'methicillin': [12], 'resistant': [13], 'strains),': [14], 'streptococci,': [15], 'enterococci': [16], 'Clostridium': [18], 'spp.': [19], 'Vancomycin': [20, 36], 'both': [24], 'widely': [25], 'used': [26], 'in': [27, 131, 151, 162, 168, 223], 'the': [28, 102, 117, 129, 134, 145], 'treatment': [29, 86, 135, 153], 'of': [30, 42, 106, 116, 128, 133, 144, 147, 159, 178, 211], 'infections': [31], 'caused': [32], 'by': [33, 68], 'Gram-positive': [34], 'organisms.': [35], 'can,': [37], 'however,': [38], 'provoke': [39], 'a': [40, 54, 138], 'number': [41], 'side-effects,': [43], 'serum': [45, 215], 'concentrations': [46], 'should': [47], 'be': [48, 61, 94], 'monitored': [49], 'during': [50], 'treatment.': [51], 'Teicoplanin': [52], 'has': [53], 'longer': [55], 'half-life': [56], 'than': [57, 126, 167], 'it': [59, 218], 'can': [60, 93], 'given': [62], 'an': [64], 'intravenous': [65], 'bolus': [66, 205], 'or': [67], 'intramuscular': [69, 207], 'injection,': [70], 'nephrotoxicity': [72], 'ototoxicity': [74], 'relatively': [76], 'uncommon.': [77], 'Treatment': [78], 'with': [79, 87, 200], 'might,': [81], 'therefore,': [82], 'offer': [83], 'advantages': [84, 201], 'over': [85], 'vancomycin-provided': [88], 'that': [89, 124, 187, 195], 'similar': [90], 'clinical': [91, 99, 139, 224], 'efficacy': [92, 103], 'shown.': [95], 'At': [96], 'least': [97], '11': [98], 'trials': [100], 'comparing': [101], 'safety': [105], 'vancomycin': [109, 171, 193], 'have': [110], 'been': [111], 'carried': [112], 'out': [113], 'worldwide.': [114], 'Meta-analysis': [115, 143], 'combined': [118], 'results': [119], 'from': [120], 'these': [121], 'studies': [122], 'indicates': [123], 'more': [125], 'three-quarters': [127], 'patients': [130, 163], 'each': [132, 152], 'groups': [136], 'had': [137], 'response': [140], 'to': [141], 'therapy.': [142], 'numbers': [146], 'adverse': [148, 160], 'events': [149, 161], 'occurring': [150], 'group': [154], 'shows': [155], 'significantly': [156], 'fewer': [157], 'reports': [158], 'receiving': [164, 170], '(13.9%)': [166], 'those': [169], '(21.9%).': [172], 'Direct': [173], 'comparisons': [174], 'difficult': [176], 'because': [177], 'inherent': [179], 'differences': [180], 'between': [181], 'studies,': [182], 'but': [183], 'available': [184], 'data': [185], 'suggest': [186], 'is': [189], 'effective': [191], 'its': [196], 'superior': [197], 'tolerability': [198], 'together': [199], 'once-daily': [204], 'administration,': [206], 'use': [208, 222], 'lack': [210], 'requirement': [212], 'for': [213, 221], 'routine': [214], 'monitoring,': [216], 'give': [217], 'considerable': [219], 'potential': [220], 'practice.': [225]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2160104373', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-23T08:02:29.415561', 'created_date': '2016-06-24'}