Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2159616534', 'doi': 'https://doi.org/10.1073/pnas.1003854107', 'title': 'B cell gene signature with massive intrahepatic production of antibodies to hepatitis B core antigen in hepatitis B virus–associated acute liver failure', 'display_name': 'B cell gene signature with massive intrahepatic production of antibodies to hepatitis B core antigen in hepatitis B virus–associated acute liver failure', 'publication_year': 2010, 'publication_date': '2010-04-26', 'ids': {'openalex': 'https://openalex.org/W2159616534', 'doi': 'https://doi.org/10.1073/pnas.1003854107', 'mag': '2159616534', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20421498', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2889296'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1003854107', 'pdf_url': 'https://www.pnas.org/content/pnas/107/19/8766.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.pnas.org/content/pnas/107/19/8766.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051190667', 'display_name': 'Patrizia Farci', 'orcid': 'https://orcid.org/0000-0003-0556-7711'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patrizia Farci', 'raw_affiliation_strings': ['Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045457706', 'display_name': 'Giacomo Diaz', 'orcid': 'https://orcid.org/0000-0003-1214-2383'}, 'institutions': [{'id': 'https://openalex.org/I172446870', 'display_name': 'University of Cagliari', 'ror': 'https://ror.org/003109y17', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I172446870']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giacomo Diaz', 'raw_affiliation_strings': ['Department of Biomedical Sciences and Technologies, University of Cagliari, 09123 Cagliari, Italy;'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences and Technologies, University of Cagliari, 09123 Cagliari, Italy;', 'institution_ids': ['https://openalex.org/I172446870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000543747', 'display_name': 'Zhaochun Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhaochun Chen', 'raw_affiliation_strings': ['Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113512282', 'display_name': 'Sugantha Govindarajan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210139427', 'display_name': 'Rancho Research Institute', 'ror': 'https://ror.org/04s7a0g31', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210139427']}, {'id': 'https://openalex.org/I2802549562', 'display_name': 'Rancho Los Amigos National Rehabilitation Center', 'ror': 'https://ror.org/03t3q6164', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1328359107', 'https://openalex.org/I2802549562']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sugantha Govindarajan', 'raw_affiliation_strings': ['Department of Pathology, Rancho Los Amigos Hospital, Downey, CA 90242;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Rancho Los Amigos Hospital, Downey, CA 90242;', 'institution_ids': ['https://openalex.org/I4210139427', 'https://openalex.org/I2802549562']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072346131', 'display_name': 'Ashley Tice', 'orcid': 'https://orcid.org/0000-0003-1007-1526'}, 'institutions': [{'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ashley Tice', 'raw_affiliation_strings': ['Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;', 'institution_ids': ['https://openalex.org/I4210134534', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055925523', 'display_name': 'Liane Agulto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Liane Agulto', 'raw_affiliation_strings': ['Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;', 'institution_ids': ['https://openalex.org/I4210134534', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002368482', 'display_name': 'Stefania Pittaluga', 'orcid': 'https://orcid.org/0000-0001-7688-1439'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stefania Pittaluga', 'raw_affiliation_strings': ['Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;'], 'affiliations': [{'raw_affiliation_string': 'Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034332376', 'display_name': 'Denali Boon', 'orcid': 'https://orcid.org/0000-0001-5532-9215'}, 'institutions': [{'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Denali Boon', 'raw_affiliation_strings': ['Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;', 'institution_ids': ['https://openalex.org/I4210134534', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109246893', 'display_name': 'Claro Yu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Claro Yu', 'raw_affiliation_strings': ['Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;', 'institution_ids': ['https://openalex.org/I4210134534', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066896324', 'display_name': 'Ronald E. Engle', 'orcid': 'https://orcid.org/0000-0003-4174-1983'}, 'institutions': [{'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ronald E. Engle', 'raw_affiliation_strings': ['Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;', 'institution_ids': ['https://openalex.org/I4210134534', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062176433', 'display_name': 'Mark Haas', 'orcid': 'https://orcid.org/0000-0002-7181-4664'}, 'institutions': [{'id': 'https://openalex.org/I1282927834', 'display_name': 'Cedars-Sinai Medical Center', 'ror': 'https://ror.org/02pammg90', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1282927834']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark Haas', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048;'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048;', 'institution_ids': ['https://openalex.org/I1282927834']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101715307', 'display_name': 'Richard Simon', 'orcid': 'https://orcid.org/0000-0003-3558-4598'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard Simon', 'raw_affiliation_strings': ['Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and'], 'affiliations': [{'raw_affiliation_string': 'Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057120979', 'display_name': 'Robert H. Purcell', 'orcid': 'https://orcid.org/0000-0003-3295-3298'}, 'institutions': [{'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert H. Purcell', 'raw_affiliation_strings': ['Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;', 'institution_ids': ['https://openalex.org/I4210134534', 'https://openalex.org/I1299303238']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070779460', 'display_name': 'Fausto Zamboni', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210166522', 'display_name': 'Azienda Ospedaliera G. Brotzu', 'ror': 'https://ror.org/05t0c7p82', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166522']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Fausto Zamboni', 'raw_affiliation_strings': ['Liver Transplantation Center, Brotzu Hospital, 09134 Cagliari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Liver Transplantation Center, Brotzu Hospital, 09134 Cagliari, Italy', 'institution_ids': ['https://openalex.org/I4210166522']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 8, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.002, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 113, 'citation_normalized_percentile': {'value': 0.999967, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '107', 'issue': '19', 'first_page': '8766', 'last_page': '8771'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10340', 'display_name': 'Hepatitis B Virus Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10340', 'display_name': 'Hepatitis B Virus Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10151', 'display_name': 'Hepatitis C virus research', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10351', 'display_name': 'Liver Disease Diagnosis and Treatment', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hbcag', 'display_name': 'HBcAg', 'score': 0.93673396}, {'id': 'https://openalex.org/keywords/hepatitis-b', 'display_name': 'Hepatitis B', 'score': 0.57366043}], 'concepts': [{'id': 'https://openalex.org/C2779729466', 'wikidata': 'https://www.wikidata.org/wiki/Q24723361', 'display_name': 'HBcAg', 'level': 5, 'score': 0.93673396}, {'id': 'https://openalex.org/C2780593183', 'wikidata': 'https://www.wikidata.org/wiki/Q6844', 'display_name': 'Hepatitis B virus', 'level': 3, 'score': 0.72236085}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.6126268}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5845343}, {'id': 'https://openalex.org/C2777382497', 'wikidata': 'https://www.wikidata.org/wiki/Q6853', 'display_name': 'Hepatitis B', 'level': 2, 'score': 0.57366043}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.54360443}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.53796905}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.48746896}, {'id': 'https://openalex.org/C2780617729', 'wikidata': 'https://www.wikidata.org/wiki/Q1356878', 'display_name': 'Hepadnaviridae', 'level': 4, 'score': 0.42625582}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.40016228}, {'id': 'https://openalex.org/C2777410769', 'wikidata': 'https://www.wikidata.org/wiki/Q2282887', 'display_name': 'HBsAg', 'level': 4, 'score': 0.32122168}], 'mesh': [{'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006510', 'descriptor_name': 'Hepatitis B Antibodies', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D006512', 'descriptor_name': 'Hepatitis B Core Antigens', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D006515', 'descriptor_name': 'Hepatitis B virus', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D017114', 'descriptor_name': 'Liver Failure, Acute', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D019070', 'descriptor_name': 'Cell Lineage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016000', 'descriptor_name': 'Cluster Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003165', 'descriptor_name': 'Complement System Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003165', 'descriptor_name': 'Complement System Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006509', 'descriptor_name': 'Hepatitis B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006509', 'descriptor_name': 'Hepatitis B', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D006509', 'descriptor_name': 'Hepatitis B', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D006509', 'descriptor_name': 'Hepatitis B', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D006510', 'descriptor_name': 'Hepatitis B Antibodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006512', 'descriptor_name': 'Hepatitis B Core Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006515', 'descriptor_name': 'Hepatitis B virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D007075', 'descriptor_name': 'Immunoglobulin M', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007075', 'descriptor_name': 'Immunoglobulin M', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D017114', 'descriptor_name': 'Liver Failure, Acute', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D017114', 'descriptor_name': 'Liver Failure, Acute', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D017114', 'descriptor_name': 'Liver Failure, Acute', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D017114', 'descriptor_name': 'Liver Failure, Acute', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009336', 'descriptor_name': 'Necrosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009336', 'descriptor_name': 'Necrosis', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D009336', 'descriptor_name': 'Necrosis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009336', 'descriptor_name': 'Necrosis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1003854107', 'pdf_url': 'https://www.pnas.org/content/pnas/107/19/8766.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2889296', 'pdf_url': 'https://europepmc.org/articles/pmc2889296?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889296', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20421498', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1003854107', 'pdf_url': 'https://www.pnas.org/content/pnas/107/19/8766.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.87, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1508521578', 'https://openalex.org/W1537701500', 'https://openalex.org/W1710129353', 'https://openalex.org/W1750043507', 'https://openalex.org/W1965172139', 'https://openalex.org/W1991912458', 'https://openalex.org/W1999843687', 'https://openalex.org/W2000598330', 'https://openalex.org/W2016042542', 'https://openalex.org/W2022824615', 'https://openalex.org/W2023279370', 'https://openalex.org/W2045183433', 'https://openalex.org/W2048024207', 'https://openalex.org/W2068682540', 'https://openalex.org/W2075003700', 'https://openalex.org/W2077467499', 'https://openalex.org/W2095544656', 'https://openalex.org/W2097905341', 'https://openalex.org/W2098459535', 'https://openalex.org/W2102697241', 'https://openalex.org/W2128941790', 'https://openalex.org/W2131381643', 'https://openalex.org/W2137011559', 'https://openalex.org/W2140949201', 'https://openalex.org/W2151625417', 'https://openalex.org/W2161455861', 'https://openalex.org/W2162540156', 'https://openalex.org/W2167335453', 'https://openalex.org/W2169773083', 'https://openalex.org/W2170680089', 'https://openalex.org/W2303218663', 'https://openalex.org/W2327856202', 'https://openalex.org/W2337600205', 'https://openalex.org/W3026674773', 'https://openalex.org/W4233520648', 'https://openalex.org/W4235029171', 'https://openalex.org/W4302344334'], 'related_works': ['https://openalex.org/W4383912859', 'https://openalex.org/W3151434364', 'https://openalex.org/W3141930008', 'https://openalex.org/W2462838746', 'https://openalex.org/W2389391447', 'https://openalex.org/W2372194100', 'https://openalex.org/W2360307815', 'https://openalex.org/W2162900068', 'https://openalex.org/W1592743141', 'https://openalex.org/W1494523999'], 'abstract_inverted_index': {'Hepatitis': [0], 'B': [1, 57, 91], 'virus': [2], '(HBV)-associated': [3], 'acute': [4], 'liver': [5, 37, 44, 64], 'failure': [6], '(ALF)': [7], 'is': [8, 52, 88, 144], 'a': [9, 15, 99, 148, 162], 'dramatic': [10], 'clinical': [11], 'syndrome': [12], 'due': [13], 'to': [14, 22], 'sudden': [16], 'loss': [17], 'of': [18, 43, 68, 85, 147, 168], 'hepatic': [19], 'cells': [20, 70], 'leading': [21], 'multiorgan': [23], 'failure.': [24], 'The': [25], 'mechanisms': [26], 'whereby': [27], 'HBV': [28], 'induces': [29], 'ALF': [30, 51, 119], 'are': [31], 'unknown.': [32], 'Here,': [33], 'we': [34], 'show': [35], 'that': [36, 81, 95, 113, 142, 157], 'tissue': [38], 'collected': [39], 'at': [40], 'the': [41, 63, 82, 89, 145, 166], 'time': [42], 'transplantation': [45], 'in': [46, 62, 165], 'two': [47, 115], 'patients': [48], 'with': [49, 65, 118, 127], 'HBV-associated': [50, 169], 'characterized': [53], 'by': [54, 76], 'an': [55, 121], 'overwhelming': [56], 'cell': [58], 'response': [59], 'apparently': [60], 'centered': [61], 'massive': [66], 'accumulation': [67], 'plasma': [69], 'secreting': [71], 'IgG': [72, 136], 'and': [73, 108, 112, 137], 'IgM,': [74], 'accompanied': [75], 'complement': [77], 'deposition.': [78], 'We': [79], 'demonstrate': [80], 'molecular': [83], 'target': [84, 146], 'these': [86, 96, 114], 'antibodies': [87], 'hepatitis': [90], 'core': [92], 'antigen': [93], '(HBcAg);': [94], 'anti-bodies': [97], 'display': [98], 'restricted': [100], 'variable': [101, 129], 'heavy': [102], 'chain': [103], '(V': [104], 'H': [105, 125, 152], ')': [106, 133], 'repertoire': [107], 'lack': [109], 'somatic': [110], 'mutations;': [111], 'unrelated': [116], 'individuals': [117], 'use': [120], 'identical': [122], 'predominant': [123], 'V': [124, 151], 'gene': [126], 'unmutated': [128], 'domain': [130], '(': [131], 'IGHV1-3': [132], 'for': [134], 'both': [135], 'IgM': [138], 'anti-HBc': [139], 'antibodies,': [140], 'indicating': [141], 'HBcAg': [143], 'germline': [149], 'human': [150], 'gene.': [153], 'These': [154], 'data': [155], 'suggest': [156], 'humoral': [158], 'immunity': [159], 'may': [160], 'exert': [161], 'primary': [163], 'role': [164], 'pathogenesis': [167], 'ALF.': [170]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2159616534', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 16}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-18T17:30:06.775197', 'created_date': '2016-06-24'}