Publication Information

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2894, 2964, 3012, 3029, 3088, 3127, 3169, 3222, 3338, 3360, 3385, 3548, 3584, 3604, 3639, 3722, 3811, 3949, 4305, 4339], 'stem': [12, 469, 490, 513, 582, 696, 723, 768, 801, 822, 918, 945, 968, 1113, 1157, 1239, 1284, 2163, 2550, 3281, 3361, 3549, 3723, 3950], 'cells': [13, 470, 520, 593, 611, 619, 697, 733, 769, 802, 813, 823, 919, 969, 1028, 1055, 1114, 2164, 2199, 2251, 2259, 2295, 2385, 2395, 2461, 2508, 2532, 2634, 2838, 2845, 2876, 3059, 3107, 3123, 3145, 3179, 3213, 3233, 3648, 3735, 3750, 3814, 3828, 3843, 3893, 3928, 4135, 4221, 4234, 4266, 4271, 4457], 'Morgan': [14, 17, 191, 194, 370], 'E.': [15, 18, 192, 195, 371], 'Carlson': [16, 19, 193, 196, 2318], 'Department': [20, 71, 174, 197, 248, 351], 'Bioengineering,': [22, 73, 176, 199, 250, 353, 390], 'University': [23, 54, 74, 99, 127, 155, 177, 200, 231, 251, 276, 304, 332, 354, 391, 411, 422], 'California,': [25, 76, 179, 202, 253, 356, 393], 'Berkeley,': [26, 77, 180, 203, 254, 357, 394], 'Berkeley': [27, 78, 181, 204, 255, 358, 395], 'CA,': [28, 79, 182, 205, 256, 359, 396], 'USA': [29, 80, 183, 206, 257, 360, 397], 'Search': [30, 58, 81, 103, 131, 159, 184, 207, 235, 258, 280, 308, 336, 361], 'for': [31, 59, 82, 104, 132, 160, 185, 208, 236, 259, 281, 309, 337, 362, 576, 746, 849, 1252, 1343, 1387, 1418, 1423, 1459, 1478, 2615, 2665, 2731, 2764, 2770, 2787, 2989, 3008, 3032, 3048, 3070, 3077, 3263, 3580, 3594, 3651, 3689, 3696, 3703, 3982, 4073, 4289, 4310, 4424, 4444], 'more': [32, 60, 83, 105, 133, 161, 186, 209, 237, 260, 282, 310, 338, 363, 3210, 3440], 'papers': [33, 61, 84, 106, 134, 162, 187, 210, 238, 261, 283, 311, 339, 364], 'by': [34, 62, 85, 107, 135, 163, 188, 211, 239, 262, 284, 312, 340, 365, 544, 638, 676, 702, 779, 827, 923, 1099, 1276, 1313, 1455, 1464, 1590, 1808, 1893, 1991, 2024, 2156, 2166, 2269, 2299, 2367, 2397, 2540, 2576, 2987, 3312, 3417, 3479, 3484, 3795, 4015, 4191, 4195, 4460, 4468], 'this': [35, 63, 86, 108, 136, 164, 189, 212, 240, 263, 285, 313, 341, 366, 554, 1199, 1381, 1536], 'author': [36, 64, 87, 109, 137, 165, 190, 213, 241, 264, 286, 314, 342, 367], 'Charlotte': [37, 39, 214, 216, 373], 'Suetta': [38, 40, 215, 217], 'Institute': [41, 92, 114, 142, 218, 269, 291, 319], 'Sports': [43, 94, 116, 144, 220, 271, 293, 321, 400, 417], 'Medicine': [44, 117, 145, 221, 294, 322, 401], 'Centre': [46, 119, 147, 223, 296, 324, 403], 'Healthy': [48, 121, 149, 225, 298, 326, 405], 'Aging,': [49, 122, 150, 226, 299, 327, 406], 'Faculty': [50, 123, 151, 227, 300, 328, 407], 'Health': [52, 125, 153, 229, 302, 330, 409], 'Science,': [53, 126, 154, 230, 303, 331, 410], 'Copenhagen,': [56, 129, 157, 233, 306, 334, 413], 'Denmark': [57, 102, 130, 158, 234, 279, 307, 335, 414, 425], 'Michael': [65, 68, 138, 140, 242, 245, 315, 317, 375, 382], 'J.': [66, 69, 243, 246, 376], 'Conboy': [67, 70, 167, 171, 244, 247, 344, 348, 386, 990, 1042, 1124, 2218, 2286, 2322, 2815, 2819, 3343], 'Per': [88, 90, 265, 267, 378], 'Aagaard': [89, 91, 266, 268], 'Sciences': [95, 272, 418], 'Clinical': [97, 274, 420], 'Biomechanics,': [98, 275, 421], 'Southern': [101, 278, 424], 'Abigail': [110, 112, 287, 289, 380], 'Mackey': [111, 113, 288, 290], 'Kjaer': [139, 141, 316, 318], 'Irina': [166, 170, 343, 347, 385], 'Corresponding': [168, 345], 'Author': [169, 346, 368], '[email': [172, 349], 'protected]': [173, 350], 'Information': [369], 'Carlson1,': [372], 'Suetta2,': [374], 'Conboy1,': [377], 'Aagaard3,': [379], 'Mackey2,': [381], 'Kjaer2': [383], '*,1': [387], '1Department': [388], '2Institute': [398], '3Institute': [415], '*Tel:': [426], '+1': [427, 432], '510': [428, 433], '666': [429], '2792;': [430], 'Fax:': [431], '642': [434], '5835': [435], 'EMBO': [436], 'Mol': [437], 'Med': [438], '(2009)1:381-391https://doi.org/10.1002/emmm.200900045': [439], 'PDFDownload': [440], 'PDF': [441], 'article': [443], 'text': [444], 'main': [446, 2124], 'figures.': [447], 'ToolsAdd': [448], 'to': [449, 498, 530, 534, 538, 609, 618, 653, 662, 716, 783, 792, 799, 812, 835, 869, 880, 978, 1007, 1023, 1032, 1036, 1081, 1165, 1203, 1367, 1432, 1483, 1499, 1699, 1716, 1742, 1788, 1932, 2017, 2183, 2260, 2264, 2276, 2301, 2335, 2363, 2449, 2511, 2562, 2571, 2676, 2719, 2784, 2826, 2863, 2935, 3083, 3219, 3381, 3429, 3476, 3495, 3560, 3642, 3729, 3773, 3825, 3884, 3941, 3962, 3971, 4063, 4236, 4342, 4374, 4386, 4391], 'favoritesDownload': [450], 'CitationsTrack': [451], 'CitationsPermissions': [452], 'ShareFacebookTwitterLinked': [453], 'InMendeleyWechatReddit': [454], 'Figures': [455], '&': [456, 904, 987, 1039, 1595, 1824, 1965, 1969, 1973, 2090, 2227, 2315, 2820, 3202, 3919, 4034], 'Info': [457], 'Abstract': [458], 'Very': [459], 'little': [460], 'remains': [461, 3995], 'known': [462, 1147, 2065], 'about': [463, 1148], 'the': [464, 475, 677, 690, 699, 718, 727, 742, 747, 828, 840, 889, 913, 927, 937, 940, 956, 995, 1001, 1012, 1062, 1149, 1205, 1253, 1277, 1280, 1299, 1368, 1375, 1606, 1652, 1666, 1673, 1682, 1694, 1706, 1718, 1888, 1909, 1926, 1934, 2059, 2079, 2098, 2107, 2112, 2127, 2142, 2178, 2184, 2246, 2255, 2277, 2291, 2343, 2365, 2379, 2391, 2443, 2453, 2474, 2504, 2514, 2563, 2572, 2690, 2700, 2797, 2924, 3119, 3135, 3149, 3187, 3215, 3227, 3259, 3264, 3272, 3276, 3288, 3305, 3320, 3359, 3372, 3395, 3400, 3464, 3491, 3532, 3661, 3677, 3713, 3788, 3826, 3840, 3847, 3887, 3901, 3923, 3939, 3963, 3972, 3983, 4003, 4038, 4096, 4110, 4118, 4127, 4138, 4179, 4200, 4211, 4256, 4268, 4432], 'regulation': [465, 3248, 3321], 'organ': [468, 667, 917, 967, 1402, 1427, 3280], '(in': [471, 3753], 'general,': [472, 1161], 'during': [474, 1705, 1738, 1856, 2051, 2056, 2464, 2533, 3153, 3251, 4017], 'process),': [477], 'most': [479, 1168], 'previous': [480], 'data': [481, 589, 1326, 1864, 1985, 2208, 2235, 2547, 3937, 4257], 'were': [482, 1496, 1616, 1723, 1840, 1920, 1986, 2403, 2613, 2638, 2660, 2687, 2985, 3146, 3208, 3503, 3649, 3670, 4189, 4335, 4422, 4458, 4466], 'collected': [483, 1497], 'in': [484, 493, 523, 532, 568, 579, 683, 755, 763, 887, 916, 926, 1000, 1026, 1085, 1088, 1093, 1111, 1160, 1215, 1232, 1244, 1262, 1301, 1347, 1354, 1374, 1398, 1406, 1490, 1541, 1553, 1567, 1618, 1679, 1693, 1725, 1780, 1814, 1848, 1883, 1925, 2038, 2068, 2097, 2106, 2170, 2177, 2187, 2200, 2238, 2245, 2262, 2310, 2342, 2424, 2434, 2442, 2452, 2485, 2503, 2509, 2527, 2557, 2580, 2600, 2625, 2640, 2741, 2802, 2834, 2842, 2856, 2872, 2881, 2890, 2898, 2913, 2930, 2946, 2955, 2977, 2995, 3039, 3086, 3102, 3124, 3148, 3162, 3166, 3214, 3235, 3254, 3284, 3293, 3319, 3350, 3422, 3438, 3457, 3461, 3490, 3505, 3522, 3608, 3637, 3654, 3660, 3736, 3778, 3833, 3861, 3866, 3886, 3900, 3906, 3933, 3966, 3975, 3986, 3992, 4024, 4057, 4132, 4137, 4260, 4282, 4315, 4337, 4357, 4420], 'short-lived': [485], 'rodents.': [486], 'We': [487, 516, 2360], 'examined': [488, 2140, 3287, 4049, 4117], 'whether': [489, 1646, 2141, 2828, 2867, 4050, 4067], 'cell': [491, 514, 893, 946, 1158, 1240, 1285, 1304, 2172, 2339, 2401, 2417, 2551, 2596, 2658, 3193, 3282, 3330, 3362, 3402, 3550, 3872, 3951, 3968, 4378], 'rodents': [494], 'could': [495, 2062, 2153], 'be': [496, 636, 2154, 2336, 2785, 3477], 'extrapolated': [497, 1990], 'genetically': [499], 'environmentally': [501], 'variable': [502], 'humans.': [503, 622], 'Our': [504, 1265, 2234], 'findings': [505, 624, 844, 1266, 1360, 3885], 'establish': [506, 2548, 2866], 'key': [507, 1384, 4184], 'evolutionarily': [508, 1292], 'conserved': [509, 1293, 3365, 3553, 3955], 'mechanisms': [510, 691, 1281, 1385, 3947], 'aging.': [515, 859, 1166], 'find': [517], 'that': [518, 557, 590, 627, 912, 931, 1005, 1268, 1330, 1866, 2008, 2103, 2237, 2296, 2549, 2604, 2921, 3108, 3246, 3317, 3370, 3414, 3512, 3751, 3943, 4002, 4095], 'satellite': [519, 592, 610, 1027, 1054, 1089, 1303, 1349, 2120, 2171, 2190, 2250, 2294, 2338, 2384, 2394, 2446, 2507, 2657, 2837, 2844, 2875, 2997, 3178, 3268, 3329, 3401, 3425, 3647, 3734, 3827, 3871, 3892, 3927, 3967, 4081, 4134, 4220, 4233, 4265, 4270, 4297, 4377, 4416, 4456], 'are': [521, 704, 770, 777, 824, 833, 970, 1137, 1242, 1274, 1291, 1956, 2297, 2340, 2350, 2757, 2928, 3063, 3364, 3420, 3487, 3552, 3682, 3938, 3953, 4012, 4437], 'maintained': [522], 'aged': [524, 736, 829, 1446, 1691, 2013, 2146, 2800, 2879], 'skeletal': [526, 694, 1394, 1469, 1599, 1871, 2429, 2981, 3011, 3255, 3301, 3583], 'muscle,': [527, 1192, 1395, 1791, 2792, 2860, 3256, 4285], 'but': [528, 776, 1143, 1753, 2254, 3155, 3164, 4330], 'fail': [529], 'activate': [531, 1024], 'response': [533, 1761, 2263, 2510], 'attrition,': [536, 1254], 'due': [537, 1080, 2275], 'diminished': [539, 1082, 1255, 2143, 2195, 2929, 2976, 3895, 4056, 4281, 4467], 'activation': [540, 602, 1077, 1095, 1344, 1373, 2281, 2552, 2779, 2869, 2971, 3309, 3969, 3991, 4009, 4075, 4227, 4291, 4462], 'Notch': [542, 578, 1013, 1025, 1048, 1076, 1094, 1318, 1346, 1372, 2280, 2781, 2831, 2848, 2868, 2885, 2909, 2925, 2948, 2970, 2994, 3023, 3050, 3099, 3247, 3262, 3308, 3990, 4011, 4044, 4074, 4125, 4172, 4290], 'compounded': [543, 1098, 3311], 'elevated': [545], 'transforming': [546], 'growth': [547, 4151], 'factor': [548, 2125, 3413, 4152], 'beta': [549], '(TGF-β)/phospho': [550], 'Smad3': [551], '(pSmad3).': [552], 'Furthermore,': [553, 2917, 4210], 'work': [555, 740, 836, 999, 1382, 1410, 2002, 2096], 'reveals': [556], 'mitogen-activated': [558, 1331], 'protein': [559, 1332, 2738, 3030, 3540, 3605, 4306], 'kinase': [560, 564, 1108, 1333, 1337], '(MAPK)/phosphate': [561, 1334], 'extracellular': [562, 1335], 'signal-regulated': [563, 1336], '(pERK)': [565, 1338], 'signalling': [566, 3481, 3562, 4069, 4098, 4278], 'declines': [567, 655, 2274, 2554], 'with': [571, 588, 656, 1163, 1306, 1357, 1792, 1904, 1958, 2181, 2252, 2387, 2390, 2473, 2555, 2642, 2754, 2878, 2942, 3046, 3134, 3394, 3531, 3558, 3621, 3846, 3960, 4104, 4255, 4324], 'age,': [572, 1074, 2253], 'is': [574, 672, 920, 1096, 1146, 1183, 1308, 1311, 1340, 1539, 2122, 2241, 2333, 2471, 2598, 2623, 2832, 2851, 2870, 2910, 2953, 2975, 3006, 3093, 3310, 3415, 3578, 3844, 3999, 4071, 4100, 4287], 'important': [575, 1342], 'activating': [577], 'cells.': [583, 1090, 2191, 2916, 2998, 3269, 4082, 4298], 'This': [584, 708, 739, 1409, 1462], 'molecular': [585, 643, 743, 788, 1152, 1206, 1235, 1365, 1399, 3273, 3354, 3946, 3980], 'understanding,': [586], 'combined': [587], 'remain': [594], 'intrinsically': [595], 'young,': [596, 1717, 1933, 3163, 3216, 3382], 'introduced': [597], 'novel': [598], 'therapeutic': [599, 847], 'targets.': [600], 'Indeed,': [601], 'MAPK/Notch': [604], 'restored': [605], '‘youthful’': [606, 639, 797], 'myogenic': [607, 1067, 1558, 2460, 2531, 2595, 3106, 3122, 3232, 3704, 3718, 3762, 3789, 3821, 3862, 4077, 4130, 4212, 4293, 4425], 'responses': [608, 798, 975, 1119, 1241, 1286, 3283, 3669, 3863, 4131, 4426, 4449], 'from': [612, 620, 804, 814, 1185, 1572, 1665, 2058, 2064, 3060, 3602, 3816, 3830], '70-year-old': [613], 'humans,': [614, 757, 808, 1142, 1216, 2204, 2558, 3285, 3557, 3818], 'rendering': [615, 809], 'them': [616, 810, 1031], 'similar': [617, 811, 1787, 3883], '20-year-old': [621], 'These': [623, 843, 1359, 1863, 1954, 2546, 3243, 3936], 'strongly': [625], 'suggest': [626, 845, 2236], 'maintenance': [632, 751, 855, 1389, 1625, 1648, 1855, 1868, 2108, 2117, 2567], 'repair': [634, 753, 958, 1136, 1173, 1391, 1403, 2110, 2357, 2798, 3335], 'can': [635], 'reversed': [637], 'calibration': [640], 'specific': [642, 4161], 'pathways.': [644], 'The': [645, 649, 861, 1227, 1533, 1776, 1980, 2035, 2456, 2524, 2649, 3140, 3172, 3979], 'paper': [646], 'explained': [647], 'PROBLEM:': [648], 'capacity': [650, 720, 3332, 3739, 4214], 'tissues': [652, 961], 'regenerate': [654], 'age': [657, 938, 947, 1307, 2556, 3841, 3848, 4105], 'eventually': [659], 'fails,': [660], 'leading': [661], 'degenerative': [663], 'disorders': [664], 'catastrophic': [666], 'failure.': [668], 'A': [669], 'textbook': [670], 'example': [671], 'wasting,': [674], 'accompanied': [675], 'loss': [678, 2160, 3327], 'strength': [680, 1491, 1997, 2045, 2134, 4054, 4099, 4279], 'agility': [682], 'older': [684, 1407, 1884, 2201], 'individuals.': [685, 1408], 'Despite': [686], 'extensive': [687], 'mice': [688, 1140, 3555], 'studies,': [689], 'regulating': [692], 'changes': [700, 925, 1214, 1250, 1273], 'caused': [701, 922, 1275, 2155], 'aging,': [703], 'not': [705, 1754, 1941, 2351, 3165, 3517], 'entirely': [706], 'understood.': [707], 'precludes': [709], 'rational': [710], 'clinical': [711], 'intervention': [712], 'such': [713, 1193, 2071, 2211], 'as': [714, 761, 873, 875, 963, 1019, 1194, 1413, 1415, 1565, 1740, 1887, 1930, 2072, 2076, 2078, 2745, 2861, 2933, 3217, 3348, 3427, 3493, 3613, 3640, 3801, 3823, 4061, 4340, 4419], 'attempts': [715, 2478], 'enhance': [717], 'regenerative': [719, 851, 932, 974, 1118, 3331, 3790, 3896, 4213], 'cells,': [724, 1350, 2447, 3426, 3724], 'or': [725, 790, 983, 1162, 2271, 3508, 4368], 'promoting': [726], 'successful': [728], 'transplantation': [729, 838], 'young': [731, 793, 819, 979, 1245, 1441, 1627, 1667, 1689, 1746, 1755, 1849, 1924, 2011, 2425, 2644, 2667, 2677, 2791, 2835, 2857, 2936, 2960, 3047, 3084, 3237, 3297, 3450, 3496, 3507, 3730, 3817, 3890, 3934, 4089, 4216, 4232, 4264, 4452], 'healthy': [732, 1388, 1624], 'into': [734, 839, 1056, 3767], 'an': [735, 1104, 1550, 2157, 2167, 3313], 'body.': [737], 'RESULTS:': [738], 'uncovers': [741], 'culprits': [744], 'responsible': [745, 1386], 'lack': [748, 1132, 1556, 2080, 2128, 2150, 2278, 2564, 2593, 3278, 3306], 'tissue': [750, 854, 858, 966, 1135, 1614, 1854, 1892, 1896, 2579, 2808, 3240], 'seen': [754, 762], 'old': [756, 765, 807, 960, 965, 1134, 1263, 1425, 1619, 1669, 1719, 1751, 1781, 1917, 1937, 2028, 2130, 2311, 2427, 2450, 2459, 2465, 2482, 2581, 2601, 2646, 2669, 2720, 2752, 2843, 2873, 2931, 2962, 2979, 3044, 3087, 3167, 3220, 3239, 3299, 3337, 3383, 3423, 3452, 3509, 3619, 3638, 3732, 3831, 3904, 3926, 4058, 4091, 4219, 4269, 4283, 4322, 4338, 4454], 'demonstrates': [759], 'that,': [760, 954], 'mice,': [764, 2239, 3304], 'actually': [771], 'capable': [772, 971, 2794], 'productive': [774, 973, 2788], 'regeneration,': [775, 1210, 2133, 2152, 3185], 'inhibited': [778, 4245], 'their': [780, 1117, 1212, 1288, 1314, 2149], 'own': [781], 'do': [784, 3516], 'so.': [785], 'However,': [786, 3997], 'particular': [787], 'cues': [789], 'exposure': [791], 'serum': [795], 'restores': [796], 'isolated': [803, 3815, 4375], '70': [805], 'year': [806, 816, 1443, 1448], '20': [815], 'olds.': [817], 'Interestingly,': [818, 907, 3499], '‘aged’': [825], 'instantly,': [826], 'tissues,': [830], 'thus': [832, 1851, 3325, 3797, 4198], 'unlikely': [834], 'upon': [837], 'old.': [841, 2864], 'IMPACT:': [842], 'clear': [846], 'targets': [848], 'boosting': [850], 'capacity,': [852], 'rejuvenating': [853], 'forestalling': [857], 'INTRODUCTION': [860], 'rate': [862, 891], 'metabolism': [864], 'cumulative': [866], 'oxidative': [867], 'damage': [868], 'DNA': [870], 'proteins,': [872], 'well': [874, 1414, 2077, 4000], 'genomic': [876], 'instability': [877], 'mutations': [879], 'mitochondrial': [881], 'DNA,': [882], 'have': [883, 910], 'all': [884, 2047, 3488, 4445], 'been': [885], 'implicated': [886], 'determining': [888], 'intrinsic': [890], 'ultimately,': [896], "species'": [897], 'life-span': [898], '(Cevenini': [899], 'et': [900, 991, 1043, 1070, 1121, 1125, 1820, 1977, 2215, 2219, 2223, 2231, 2283, 2287, 2319, 2323, 2811, 2816, 3198, 3340, 3344, 4030], 'al,': [901, 992, 1044, 1071, 1122, 1126, 1821, 1978, 2216, 2220, 2224, 2232, 2284, 2288, 2320, 2324, 2812, 2817, 3199, 3341, 3345, 4031], '2008;': [902], 'Vijg': [903], 'Campisi,': [905], '2008).': [906, 1072], 'recent': [908], 'studies': [909, 1963, 1993, 2193], 'delineated': [911], 'process': [915, 3189], 'largely': [921], 'age-specific': [924, 1213, 1249, 1289, 1369, 1551, 2036, 2066, 2158, 2168, 2185, 2501, 2525, 3277, 3624, 3859, 3964, 3984], 'differentiated': [928], 'niches,': [929], 'outcomes': [933], 'often': [934], 'depend': [935], 'on': [936, 944, 1908, 1994, 2094, 2735, 3027, 3676, 3717, 3743, 4303, 4431], 'niche,': [941], 'rather': [942], 'than': [943, 1923, 2033], '(Grounds,': [948, 2085], '1998).': [949], 'It': [950], 'was': [951, 1453, 1588, 1649, 1685, 1702, 1783, 1846, 1940, 2496, 2537, 2733, 2782, 3535, 3611, 3635, 3727, 3740, 3792, 3864, 3929, 4222, 4243, 4308, 4354], 'further': [952, 1097, 1987, 3434], 'established': [953, 1329, 4001], 'despite': [955], 'deteriorated': [957, 3334], '(such': [962], 'muscle),': [964], 'when': [976, 3186, 3771, 3898, 3931, 4241], 'exposed': [977], 'extrinsic': [980], 'milieu': [981], '(myofibres': [982], 'blood': [984], 'sera)': [985], '(Carlson': [986, 1120, 2282, 2314, 2810, 3339, 3918], 'Conboy,': [988, 2091, 2316, 3203, 3920], '2007;': [989, 2217, 2317], '2005).': [993, 2092], 'At': [994], 'mechanistic': [996], 'level,': [997], 'our': [998, 2095, 2369], 'mouse': [1002, 2312, 2804, 3367, 3805, 3888, 3957, 3993], 'model': [1003, 1220, 2370, 2805], 'defined': [1004], 'injury': [1006, 1178, 2267, 2300, 2809], 'myofibres,': [1008, 1752, 2147, 2932], 'induces': [1009], 'expression': [1010, 1084, 3988, 4004], 'ligand': [1014, 2849, 2926, 2951], 'Delta,': [1015, 3097, 4121, 4350], 'which': [1016, 1065, 1182, 1248, 1481, 2470, 2559, 3392], 'thereby': [1017], 'acts': [1018], 'a': [1020, 1218, 1270, 1362, 1758, 2104, 2123, 2212, 2337, 2439, 2497, 2746, 2803, 3439, 3519, 3802], 'positional': [1021], 'cue': [1022], 'causes': [1030, 1549, 3981], 'break': [1033], 'quiescence': [1034], 'proliferate': [1037], '(Conboy': [1038], 'Rando,': [1040, 2821], '2002;': [1041, 1822, 2225, 4032], '2003).': [1045, 1127, 2289, 2325, 3346], 'Activation': [1046], 'also': [1049, 2538, 2919, 3444], 'prevents': [1050], 'premature': [1051], 'differentiation': [1052, 1068, 3188, 3763], 'fusion-competent': [1057, 2306, 4239], 'myoblasts,': [1058, 3748], 'through': [1059, 1195, 1317, 4225], 'inhibition': [1060], 'Wnt': [1063], 'pathway,': [1064], 'promotes': [1066], '(Brack': [1069], 'With': [1073], 'however,': [1075], 'becomes': [1078, 1352, 1404, 2840, 3249, 4055, 4280], 'lacking': [1079, 2871], 'Delta': [1083, 2850, 2927, 2952, 2973, 3000, 3025, 3987, 4006, 4156, 4169, 4400, 4409], 'myofibres': [1086, 1734, 1747, 1803, 1877, 2389, 2575, 2937], 'Such': [1091], 'decline': [1092, 1300, 1370, 2037, 2105, 2169, 2186, 2213, 2244, 2309, 2441, 2502, 2526, 2945, 3101, 3965, 3985], 'excessive': [1100, 3421], 'TGF-β/phospho-Smad': [1101], '(pSmad),': [1102], 'causing': [1103, 2126], 'accumulation': [1105], 'cyclin-dependant': [1107], '(CDK)': [1109], 'inhibitors': [1110, 3515], 'preventing': [1116], '2008a;': [1123, 2285, 2321, 3342], 'Age-specific': [1128], 'atrophy': [1130, 1452, 1548, 2516], 'common': [1138], 'between': [1139, 1294, 1440, 1688, 3366, 3554, 3804, 3956], 'virtually': [1144], 'nothing': [1145], 'cellular': [1150, 1233, 3944], 'determinants': [1153, 1207], 'behaviour': [1159], 'respect': [1164, 2182, 3559, 3961], 'Additionally,': [1167, 1750, 2345, 3882], 'animal': [1169, 1962, 2099], 'models': [1170], 'study': [1171], 'after': [1174, 1471, 1503, 1512, 1525, 1878, 2026, 2375, 2513, 2535, 2607, 3090, 3130, 3181], 'extreme': [1175], 'types': [1176], '(e.g.': [1179], 'cardiotoxin': [1180, 2270, 2346], 'injection),': [1181], 'different': [1184, 1687, 1704, 2409], 'physiological': [1186, 1219, 2352], 'attrition': [1187], 'regeneration': [1189, 1256, 1435, 1486, 1517, 1529, 1874, 2084, 2374, 2480, 2789], 'physical': [1196, 2159], 'activity.': [1197], 'In': [1198, 1378, 1430, 1834, 1902, 2940, 3303], 'work,': [1200], 'we': [1201, 1328, 1659, 2101, 2138, 2824, 2883, 2918, 3286, 3443, 4048, 4116], 'sought': [1202], 'identify': [1204], 'via': [1217, 2118], 'acute': [1222, 1465, 2807], 'exercise': [1223, 1466, 1948, 2512, 2534, 2606, 3129], 'following': [1224, 1944, 4359], 'atrophy.': [1226, 1713], 'results': [1228, 3244, 3318, 3437], 'shown': [1229, 1678, 2433, 2484, 2624, 2897, 3007, 3349, 3456, 3579, 3777, 4258], 'here': [1230], 'define,': [1231], 'terms,': [1236, 1400], 'how': [1237], 'regulated': [1243, 4014], 'individuals': [1246, 1782, 2014], 'account': [1251], 'poor': [1258], 'function': [1260], 'manifested': [1261, 1886], 'age.': [1264, 1358], 'reveal': [1267], 'while': [1269, 2009, 2205, 3206, 4160, 4404], 'diversity': [1271], 'process,': [1279], 'controlling': [1282], 'alternations': [1290], 'humans': [1295], 'mice.': [1297], 'Specifically,': [1298], 'performance': [1305], 'extrinsic,': [1309], 'imposed': [1312], 'myofibre': [1315, 1451, 1778, 2373, 2398], 'niches': [1316], 'TGF-β/pSmad': [1320, 3291, 3627], 'imbalance.': [1321, 3563], 'Confirming': [1322], 'extrapolating': [1324], 'these': [1325, 1905, 2021, 2198, 2258, 2636, 2943, 3353, 3436, 3513, 3834, 4114], 'further,': [1327], 'pathway': [1339, 3292, 4053], 'both': [1341, 1766, 1867, 2010, 2643, 2666, 3049, 3236, 4451], 'down-regulated': [1353, 2841, 4103], 'provide': [1361], 'previously': [1363], 'unknown': [1364], 'explanation': [1366], 'compartment.': [1377], 'its': [1379, 1793, 2950, 3799], 'sum,': [1380], 'identifies': [1383], 'clarifies': [1397], 'why': [1401], 'inadequate': [1405], 'has': [1411], 'theoretical,': [1412], 'translational': [1416], 'significance': [1417, 3374, 4112], 'understanding': [1419, 3274], 'enhancing': [1424], 'repair.': [1428], 'RESULTS': [1429], 'order': [1431], 'compare': [1433, 2378], 'success': [1436, 4201], 'functional': [1438, 1488, 1519, 1531, 1891, 1992, 2022, 2114, 4111], 'recovery': [1439, 1709, 1773, 2057], '(∼20': [1442], 'old)': [1444, 1449], '(∼70': [1447], 'individuals,': [1450, 1692, 1885], 'induced': [1454, 3478, 4155, 4190], 'immobility': [1456, 1500, 1507, 1707, 1731, 1857, 2467, 2536], '(cast': [1457], 'application': [1458], 'two': [1460], 'weeks).': [1461, 1749], 'followed': [1463], '(loading)': [1467], 'cast': [1472, 1513, 1526, 1879, 1945], 'removal': [1473, 1514, 1527, 1946], '(for': [1474], '3': [1475, 1510, 1767, 2704, 2725, 3036, 3159], 'days': [1476, 1511, 1768, 2518, 3160], '4': [1479, 1523, 1585, 1770, 2520, 2707, 3224], 'weeks),': [1480, 2469, 2521], 'aimed': [1482], 'promote': [1484], 'improvement': [1489], 'agility.': [1493, 2136], 'Muscle': [1494, 1570], 'biopsies': [1495, 1671], 'prior': [1498], '(basal': [1501], 'level),': [1502], '2': [1504, 2693, 2701, 2722, 3033, 3754, 4153], 'weeks': [1505, 1524, 1771, 3183, 3225], '(induced': [1508, 2268], 'atrophy),': [1509], '(initiation': [1515], 'recovery)': [1520, 1587], 'at': [1522, 1672, 1765, 2479, 2678, 2689, 2721, 2853, 3158, 3223], '(ongoing': [1528], 'recovery).': [1532], 'scheme': [1534], 'experimental': [1537, 1563, 2327, 4203], 'setup': [1538], 'depicted': [1540], 'Fig': [1542, 1680, 2435, 2486, 2489, 2522, 2585, 2899, 2902, 3351, 3458, 3462, 3779, 3783, 4249], '1A.': [1543], 'Figure': [1544, 2590, 2968, 3544, 4275], '1.': [1545], 'Immobility-induced': [1546], 'increase': [1552, 3314], 'degeneration': [1554, 1611, 1737, 1744, 1779, 2476], 'recovery.': [1559], 'A..': [1560, 2609, 2983, 3566], 'Scheme': [1561], 'setup,': [1564], 'described': [1566], 'text.': [1568], 'B..': [1569, 2648, 2999, 3572, 4300], 'histology': [1571, 1684, 1981], 'resting': [1573, 3294], 'state': [1574, 1697, 3151], '(pre),': [1575], 'immobility-atrophy': [1576, 1656], '(2': [1577, 1748, 2468], 'week': [1578, 1586, 2694, 2702, 2708, 2723, 3034], 'imm.)': [1579], 'loading-recovery': [1581], '(3': [1582, 2517], 'day': [1583, 2705, 3868], 'recovery,': [1584], 'analysed': [1589, 1660, 2688, 2986, 3671, 4423], 'haematoxylin': [1591], 'eosin': [1593], '(H': [1594], 'E)': [1596], '10-µm': [1598], 'cryosections.': [1601, 2431, 3013, 3061, 3073, 3585], 'During': [1602], 'immobilization': [1603, 2697], 'phase': [1604], 'study,': [1607], 'areas': [1608], 'severe': [1610, 1736], 'scar': [1613, 1763, 1895, 2578], 'formation': [1615, 1764], 'evident': [1617], 'muscles': [1620, 1629, 2029, 3994], '(yellow': [1621], 'arrows)': [1622], 'versus': [1623], 'immobilized': [1628, 1870], '(white': [1630], 'arrows).': [1631], 'Scale': [1632], 'bar': [1633], '=': [1634, 1638, 2762, 2768, 3068, 3075, 3687, 3694, 3701, 4442], '100': [1635], 'µm.': [1636], 'n': [1637, 2761, 2767, 3067, 3074, 3686, 3693, 3700, 4441], '10.': [1639], 'Download': [1640, 1642, 2774, 2776, 3114, 3116, 3707, 3709, 4472], 'figure': [1641, 2775, 3115, 3708], 'PowerPoint': [1643, 2777, 3117, 3710], 'To': [1644, 2865, 3270, 3433, 3711], 'determine': [1645, 1865, 2827], 'age-dependent': [1650], 'under': [1651, 2046], 'conditions': [1653, 2049], 'mobility,': [1655], 'loading-recovery,': [1658], '10': [1661, 2663, 2763, 3009, 3581, 4365, 4369], 'µm': [1662, 3010, 3582], 'cryosections': [1663, 2612, 2891], 'derived': [1664, 3829], 'indicated': [1674], 'time': [1675, 2709], 'points.': [1676], 'As': [1677, 1714, 2432, 2896, 3081, 3379, 3455, 3776, 4177], '1B,': [1681], 'markedly': [1686], 'basal': [1695, 2018, 2454, 3150], '(‘Pre’)': [1696], '(prior': [1698], 'immobility)': [1700, 3131], 'particularly': [1703], 'periods': [1710], 'immobility-induced': [1712, 2060, 2515], 'compared': [1715, 1741, 1931, 2675, 2718, 2753, 2862, 2934, 3045, 3082, 3218, 3380, 3428, 3494, 3620, 3641, 3824, 4062, 4323, 4341, 4385, 4390], 'fibres': [1722, 1919, 1939, 3386], 'uneven': [1724, 1809], 'size': [1726, 1935, 1984, 2043, 2144], 'less': [1728], 'numerous': [1729], 'before': [1730], '(Pre).': [1732], 'Old': [1733], 'underwent': [1735], 'immobility,': [1739, 2027, 3091, 3154], 'mild': [1743], 'ones,': [1756], 'exhibited': [1757, 3819], 'persistent': [1759], 'inflammatory': [1760], '(Fig': [1774, 1827, 1858, 1897, 1949, 2003, 2543, 2583, 2938, 2965, 3170, 3195, 3241, 3404, 3431, 3851, 3874, 3910, 4106, 4174, 4207, 4246, 4272], '1B).': [1775], 'immobility-caused': [1777], 'highly': [1784, 3954], 'pronounced': [1785], 'pathological': [1789], 'degenerating': [1790], 'typical': [1794, 1847], 'clusters': [1795, 1839], 'new': [1797], 'embryonic': [1798, 4018], 'myosin': [1799], 'heavy': [1800], 'chain': [1801], '(eMyHC+)': [1802], 'broken': [1805], 'sarcolemma,': [1806], 'evidenced': [1807], 'pattern': [1810], 'dystrophin,': [1812], 'e.g.': [1813, 3749], 'cases': [1815], 'congenital': [1817], 'myopathies': [1818], '(Renault': [1819], 'Straub': [1823], 'Bushby,': [1825], '2006)': [1826], 'S1A': [1828], 'B': [1830, 4316], 'Supporting': [1832, 1861, 1900, 1952, 2006, 2492, 2588, 2905, 3786, 3880, 3916, 4252], 'Information).': [1833, 1862, 1901, 1953, 2589, 3881, 4253], 'contrast,': [1835], 'acutely': [1836], 'deteriorating': [1837], 'absent,': [1841], 'intact': [1843], 'dystrophin+': [1844], 'sarcolemma': [1845], 'muscles,': [1850, 4060, 4093], 'suggesting': [1852, 3511], 'better': [1853], 'S1': [1859, 2490, 2586, 3878, 3914], 'atrophic': [1876], 'removal,': [1880], 'become': [1881], 'inefficient': [1882], 'replacement': [1889, 2573], 'fibrotic': [1894], 'S1C–F': [1898], 'accordance': [1903], 'findings,': [1906, 4115], 'based': [1907, 3675, 3742, 4430], 'quantification': [1910], 'quadricep': [1912], 'cross-sectional': [1914], 'area': [1915], '(MRI),': [1916], 'much': [1921], 'smaller': [1922], '‘pre’': [1927, 2679], 'state,': [1928], 'efficiently': [1942], 'recovered,': [1943], 'S2A': [1950], 'observations': [1955], 'consistent': [1957, 2472], 'published': [1959, 2179, 2207], 'literature': [1960], '(Brown': [1964], 'Hasser,': [1966], '1996;': [1967], 'Degens': [1968], 'Alway,': [1970], '2003;': [1971, 2221, 2818], 'Machida': [1972], 'Booth,': [1974], '2005;': [1975, 3200], 'Pistilli': [1976], '2007).': [1979, 3921], 'confirmed': [1988, 2539], 'concentric/isometric': [1996], 'total': [1999, 2650, 3228], 'contraction': [2001], 'S2B–D': [2004], 'Information)–establishing': [2007], 'recovered': [2015], 'close': [2016], 'levels': [2019, 2855, 2922, 3026, 3136, 3389, 3407, 3465, 4119, 4173, 4180, 4327, 4332, 4398], 'parameters,': [2023, 2070], 'exercising': [2025], 'always': [2030], 'remained': [2031], 'weaker': [2032], 'young.': [2034, 2755, 3622, 3643, 4325, 4343], 'fibre': [2040, 2083], 'maintenance,': [2041], 'repair,': [2042, 2569], 'studied': [2048, 3523], '(i.e.': [2050], 'normal': [2052], 'use': [2054], 'atrophy)': [2061], 'result': [2063], 'alterations': [2067], 'many': [2069], 'innervation': [2073], 'vascularization,': [2075], '1998;': [2086], 'Thomas,': [2087], '2001;': [2088], 'Wagers': [2089, 3201], 'Based': [2093], 'model,': [2100, 3889], 'hypothesized': [2102], 'unit': [2115], '(myofibre': [2116], 'resident': [2119, 2996], 'cells)': [2121], 'Thus,': [2137], 'next': [2139], 'and/or': [2165], 'activation.': [2173], 'Certain': [2174], 'controversy': [2175], 'exists': [2176], 'literature,': [2180], 'numbers': [2188, 2196, 2292, 2402, 2528, 2651, 3103, 3141, 3173], 'Some': [2192], 'report': [2194], 'animals': [2202], 'other': [2206], 'argues': [2209], 'against': [2210], '(Collins': [2214, 3197], 'Renault': [2222], 'Schultz': [2226], 'Lipton,': [2228], '1982;': [2229], 'Shefer': [2230], '2006).': [2233], 'there': [2240, 2495, 3092, 3207], 'no': [2242], 'significant': [2243, 3094], 'number': [2247, 2380, 2392, 2444, 2457, 2683, 3229, 3744], 'quiescent': [2249, 2382], 'ability': [2256], 'expand': [2261, 2302], 'traumatic': [2265], 'dry': [2272, 2348], 'ice)': [2273], 'Consequentially,': [2290], 'activated': [2298, 2396, 3231, 3416], 'produce': [2304, 4237], 'proliferating': [2305, 3747, 4238], 'myoblasts': [2307, 4240], 'dramatically': [2308, 3793], 'Different': [2326], 'systems': [2328], 'standards': [2330], 'what': [2332], 'considered': [2334], 'used': [2341, 3612], 'field.': [2344], 'ice': [2349], 'agents': [2353], 'remodelling.': [2359], 'therefore': [2361], 'decided': [2362], 'clarify': [2364], 'situation': [2366], 'using': [2368, 2405, 2743, 3537], 'atrophy,': [2376], 'associated': [2386, 2877], 'undamaged': [2388], 'deterioration.': [2399], 'Satellite': [2400, 3813], 'quantified,': [2404], 'immuno-detection': [2406, 2622, 3005, 3526], 'three': [2408], 'markers:': [2410], 'paired': [2411], 'box': [2412], 'gene': [2413], '7': [2414, 3867], '(Pax7),': [2415], 'neural': [2416], 'adhesion': [2418], 'molecule': [2419, 3726], '(NCAM)': [2420], 'muscle-cadherin': [2422], '(M-Cadherin),': [2423], '2A–C,': [2436], 'produces': [2438], '∼2-fold': [2440], 'endogenous': [2448], 'state.': [2455], 'increases': [2462], 'slightly': [2463], 'ongoing': [2475], 'tissue,': [2483, 3085, 3510], '1B': [2487], 'Information.': [2493], 'Importantly,': [2494], 'very': [2498], 'pronounced,': [2499], '∼4-fold': [2500], 'expansion': [2505, 2597, 3120, 3194, 3265], '2A–C.': [2523], 'Pax7': [2530, 2732, 2887, 3110], 'Western': [2541, 2729, 2771, 2956, 3020, 3078, 3446, 3592, 3697, 4085, 4301, 4346], 'blotting': [2542, 2730, 3079, 3593, 3698], '2D,': [2544], 'E).': [2545], 'significantly': [2553, 4102, 4167, 4223], 'may': [2560], 'contribute': [2561], 'fibrous': [2577], 'people': [2582, 3832], '1,': [2584], '2.': [2591], 'Pronounced': [2592], 'detected': [2599, 2912, 3636, 4336], 'undergoes': [2605], 'immobility.': [2608], 'Skeletal': [2610], 'immunostained': [2614, 2765], 'Pax7,': [2616, 2653], 'M-Cadherin': [2617], 'NCAM': [2619, 2654], '(green).': [2620], 'Laminin': [2621], 'red': [2626], 'Hoechst': [2628, 3014, 3586], 'labels': [2629, 3015, 3587], 'nuclei': [2630, 2659, 2686, 3016, 3588], '(blue).': [2631, 3017, 3589], 'Sublaminar': [2632], 'mono-nucleated': [2633], 'expressing': [2635], 'markers': [2637], 'identified': [2639], 'association': [2641], 'myofibres.': [2647], 'M-Cadherin+': [2656], 'quantified': [2661, 3038, 3607, 3673, 4314, 4428], 'per': [2662], 'mm2': [2664], 'muscles.': [2670, 3454], '*P': [2671, 2749, 3041, 3616], '≤': [2672, 2715, 2750, 3042, 3617, 4320, 4382], '0.05': [2673, 2716], '(old': [2674], 'condition).': [2680], 'C..': [2681], 'Total': [2682], 'Pax7+': [2685, 2914], 'pre': [2691], '(resting': [2695], 'phase)': [2698], '+': [2703, 2724, 3035, 3769], 'points': [2710], '(regeneration': [2711], 'phase).': [2712], '*,': [2713, 4318, 4380], 'P': [2714, 4319], '(young': [2717], 'day).': [2726], 'D,': [2727], 'E..': [2728, 3053], 'performed': [2734, 2884, 3445, 3536, 4309, 4355], 'whole': [2736, 3028, 3603, 4304], 'isolates': [2739, 3031, 4307], '(quantified': [2740, 3460, 4356], 'E),': [2742], 'actin': [2744], 'loading': [2747, 3614], 'control.': [2748, 3615], '0.05,': [2751, 3043, 3618, 4321, 4383], 'Data': [2756, 3062, 3681, 4436], 'means': [2758, 3064, 3683, 4438], '±': [2759, 3065, 3684, 4439], 's.d.': [2760], 'cryosections,': [2766, 3692], '6': [2769, 3076, 3695, 3702, 4443], 'blot': [2772, 2957, 3021, 3447, 4086, 4302, 4347], 'analysis.': [2773, 3080], 'Previously,': [2778], 'determined': [2783], 'indispensable': [2786], 'rescuing': [2796], '2008a,': [2813], '2008b;': [2814], '2002).': [2822, 4036], 'Therefore,': [2823], 'set': [2825], '(1)': [2829, 4051], 'active': [2830, 2908, 2947, 3098, 3112, 3138, 3144, 3176, 3212, 3485, 4124, 4158, 4171, 4402, 4411], 'present': [2833], '(2)': [2847, 4066], 'expressed': [2852], 'higher': [2854, 3388, 3489, 3820, 3856], 'regenerating': [2859, 2978, 3125, 3296], 'vivo,': [2882], 'co-immunodetection': [2888], 'experiments': [2889], 'biopsies.': [2895], '3A': [2900], '(and': [2901], 'S3': [2903], 'Information),': [2906], 'nuclear': [2907, 2992, 3409], 'eagerly': [2911], 'myofibre-associated': [2915, 3058, 3105], 'found': [2920], '3B).': [2939], 'agreement': [2941], 'data,': [2944], 'observed': [2954, 3865], 'analysis': [2958, 3448, 4087], '3C,': [2966], 'D).': [2967, 4176, 4209], '3.': [2969], 'upregulation': [2974], 'muscle.': [2982, 3302, 3498], 'Cryosections': [2984], 'immunostaining': [2988], 'co-expression': [2990, 3678, 4433], 'Pax7+/active': [2993], '(red)': [3001, 3577], 'dystrophin': [3003], '(green)': [3004, 3568, 3574], 'C,': [3018, 3590, 4344, 4421], 'D..': [3019, 3591, 4345], 'day;': [3037], 'D.': [3040, 3609], 'Delta.': [3052], 'Quantification': [3054], 'Notch/Pax7': [3056], 'double-positive': [3057], 's.d.,': [3066, 3685, 4440], '10–15': [3069, 3688], 'immunodetection': [3071, 3690], 'loaded': [3089], 'down-regulation': [3095], 'co-express': [3109, 3759], 'Notch.': [3113, 3139, 3978, 4412], 'Notably,': [3118], '(during': [3128], 'positively': [3132, 4013], 'correlated': [3133], 'Pax7+/Notch': [3143, 3175, 3211], 'low': [3147], 'greatly': [3156], 'increased': [3157], 'post-immobility': [3161], '3E).': [3171, 3242], 'declined': [3180, 3234], 'several': [3182, 4021], 'typically': [3190], 'follows': [3191], 'initial': [3192], '3E': [3196], '2005)).': [3204], 'Accordingly,': [3205, 3406], 'still': [3209], 'post-immobility,': [3226], 'demonstrate': [3245, 3942], 'altered': [3250], 'suggests': [3258, 3371], 'importance': [3260], 'deepen': [3271], 'activity': [3289], 'TGF-β/pSmad3': [3316], 'CDK': [3323, 3470, 3514, 3630], 'inhibitors,': [3324, 3471, 3631], 'assuring': [3326], 'Remarkably,': [3347, 4147], '4,': [3352], 'signatures': [3355], 'within': [3358], 'compartment': [3363], 'fundamental': [3373], 'uncovered': [3376], 'regulatory': [3377], 'mechanisms.': [3378], 'contain': [3387], 'TGF-β,': [3391, 3467, 3595], 'associates': [3393], 'laminin-rich': [3396], 'basement': [3397], 'membrane': [3398], 'microniche': [3403], '4A).': [3405], 'pSmad3': [3410, 3468], '(the': [3411], 'transcriptional': [3412], 'TGF-β': [3418, 3480, 3561, 3567, 3716, 3976], 'signalling)': [3419], 'youngs': [3430, 4064], '4B).': [3432], 'confirm': [3435], 'quantitative': [3441], 'way,': [3442], '4C': [3459], '4D),': [3463], 'p15': [3472, 3632], 'p21': [3474, 3634], '(known': [3475], 'reduced': [3483, 3794, 4194], 'Notch)': [3486], 'old,': [3492], 'p27': [3500, 3528, 3601], 'p16': [3502, 3530, 3599], 'undetectable': [3504], 'either': [3506], 'play': [3518], 'major': [3520], 'role': [3521, 3800], 'processes.': [3524], 'Efficient': [3525], 'same': [3533], 'antibodies': [3534], 'positive': [3538], 'control': [3539, 4261], 'extracts': [3541], '(not': [3542], 'shown).': [3543], '4.': [3545], 'Mechanisms': [3546], 'Immunodetection': [3564], 'of:': [3565], 'laminin': [3570, 3576], '(red),': [3571], 'P-Smad3': [3573], 'P-Smad3,': [3596], 'p15,': [3597], 'p21,': [3598], 'lysates;': [3606], 'Actin': [3610], 'Significant': [3623], 'elevation': [3625], 'E,': [3644, 4413], 'F..': [3645, 4414], 'Activated': [3646, 4415], 'cultured': [3650, 3899, 3932, 4136, 4418], '24': [3652, 3835, 4360], 'h': [3653, 3836, 4361], 'OPTI-MEM': [3655], 'containing': [3656], 'age-matched': [3657], 'sera': [3659, 3850, 3905], 'presence': [3662, 3902, 4139], '25': [3664], 'ng/ml': [3665, 4366], 'recombinant': [3666], 'TGF-β1.': [3667], 'Myogenic': [3668, 3738, 4448], 'F,': [3674, 4248, 4429], 'desmin/BrdU.': [3680, 4435], 'analysis,': [3699], 'culture': [3705], 'experiments.': [3706], 'examine': [3712], 'effects': [3714], 'properties': [3719, 4078, 4294], 'exogenous': [3725, 4362], 'added': [3728], 'culture.': [3737], 'determined,': [3741], 'fusion-competent,': [3746], 'rapidly': [3752], 'h)': [3755], 'incorporate': [3756], 'bromodeoxyuridine': [3757], '(BrdU),': [3758], 'desmin': [3760], '(MyoD)': [3764], 'fuse': [3766], 'eMyHC': [3768], 'myotubes': [3770], 'transferred': [3772], 'mitogen-low': [3774], 'medium.': [3775], '4E,': [3780, 3852], 'F': [3781], 'S4': [3784], 'Information,': [3787], 'potential': [3791, 3822], 'TGF-β1,': [3796], 'confirming': [3798], 'conserve': [3803], 'negative': [3808], 'regulator': [3809], 'regeneration.': [3812], 'isochronic': [3837, 3869, 4262], 'cultures,': [3838, 4263], 'where': [3839, 4317], 'matched': [3845], 'F).': [3853, 4274], 'An': [3854], 'even': [3855, 4231], 'magnitude': [3857], 'deficiency': [3860], 'cultures': [3873, 4379], 'S5': [3875, 3911], 'Table': [3877, 3913], 'had': [3894], 'responses,': [3897], 'heterochronic': [3907], 'co-culture': [3908], 'assays': [3909], 'Information)': [3917], 'Conversely,': [3922], 'myogenicity': [3924], 'improved': [3930], 'sera.': [3935], 'first': [3940], 'human,': [3959], 'biochemical': [3973], 'imbalance': [3974], 'unknown.': [3996], 'it': [3998], 'subsequent': [4008], 'MAPK': [4016, 4046, 4052, 4068, 4097, 4145, 4148, 4164, 4206, 4242, 4277, 4396, 4407, 4464], 'development': [4019], 'distinct': [4022], 'organs': [4023], 'Drosophila': [4025], 'Caenorhabditis': [4027], 'elegans': [4028], '(Carmena': [4029], 'Shaye': [4033], 'Greenwald,': [4035], 'Exploring': [4037], 'evolutionary': [4039], 'developmental': [4041], 'conservation': [4042], 'cross-talk,': [4047], 'intensity': [4070], 'causal': [4072, 4288], 'Quite': [4083], 'interestingly,': [4084], 'demonstrated': [4094], 'indeed': [4101], '5A,': [4107], 'B).': [4108], 'Extrapolating': [4109], 'amounts': [4122], 'efficiency': [4128], 'agonists': [4141], 'antagonists': [4143], 'pathway.': [4146], 'agonist': [4149], 'fibroblast': [4150], '(FGF-2)': [4154], 'Notch,': [4159, 4349, 4403], 'inhibitor': [4162, 4372], '(MEK': [4165], 'inhibitor)': [4166], 'attenuated': [4168], '5C,': [4175, 4208], 'expected,': [4178], 'pERK': [4182], '(a': [4183], 'downstream': [4185], 'effector': [4186], 'MAPK)': [4188], 'FGF-2': [4192], 'MEK': [4196, 4371], 'inhibitor,': [4197], 'validating': [4199], 'modulation': [4204], 'importantly,': [4218], 'enhanced': [4224, 4459], 'forced': [4226, 4461], 'MAPK,': [4229], 'failed': [4235], 'experimentally': [4244], '5E,': [4247, 4273], 'S6': [4250], 'Consistent': [4254], 'above': [4259], 'outperformed': [4267], '5.': [4276], 'A,': [4299], 'P-Erk': [4311, 4351], 'Erk,': [4313, 4329], 'Similar': [4326], 'lower': [4331], 'pErk': [4334], 'Erk': [4353], 'D),': [4358], 'addition': [4363], 'FGF': [4367], 'µM': [4370], '(MEKi)': [4373], '**P': [4381], '+FGF': [4384], 'Control': [4387], '+MEKi': [4389], 'Control.': [4392], 'Experimental': [4393], 'attenuation': [4394, 4469], 'decreases': [4397], 'induction': [4405], 'up-regulates': [4408], 'cell,': [4417], 'panels': [4446], 'indicated.': [4447], 'MAPK.': [4471]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2159524128', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 19}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 17}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 23}, {'year': 2015, 'cited_by_count': 18}, {'year': 2014, 'cited_by_count': 20}, {'year': 2013, 'cited_by_count': 25}, {'year': 2012, 'cited_by_count': 20}], 'updated_date': '2024-12-12T22:26:11.748683', 'created_date': '2016-06-24'}