Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2159497705', 'doi': 'https://doi.org/10.4049/jimmunol.175.3.1686', 'title': 'Augmentation of Effector CD8+ T Cell Generation with Enhanced Granzyme B Expression by IL-27', 'display_name': 'Augmentation of Effector CD8+ T Cell Generation with Enhanced Granzyme B Expression by IL-27', 'publication_year': 2005, 'publication_date': '2005-08-01', 'ids': {'openalex': 'https://openalex.org/W2159497705', 'doi': 'https://doi.org/10.4049/jimmunol.175.3.1686', 'mag': '2159497705', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16034109'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.175.3.1686', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/175/3/1686/1205773/1686.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://journals.aai.org/jimmunol/article-pdf/175/3/1686/1205773/1686.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108532537', 'display_name': 'N. MORISHIMA', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I158929114', 'display_name': 'Tokyo Medical University', 'ror': 'https://ror.org/00k5j5c86', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I158929114']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Noriko Morishima', 'raw_affiliation_strings': ['*Intractable Immune System Disease Research Center and', '†Department of Immunology, Tokyo Medical University, Tokyo, Japan; and'], 'affiliations': [{'raw_affiliation_string': '*Intractable Immune System Disease Research Center and', 'institution_ids': []}, {'raw_affiliation_string': '†Department of Immunology, Tokyo Medical University, Tokyo, Japan; and', 'institution_ids': ['https://openalex.org/I158929114']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108559522', 'display_name': 'Toshiyuki Owaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161296585', 'display_name': 'Tokyo University of Science', 'ror': 'https://ror.org/05sj3n476', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I161296585']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshiyuki Owaki', 'raw_affiliation_strings': ['*Intractable Immune System Disease Research Center and', '‡Department of Patho-Physiology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan'], 'affiliations': [{'raw_affiliation_string': '*Intractable Immune System Disease Research Center and', 'institution_ids': []}, {'raw_affiliation_string': '‡Department of Patho-Physiology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan', 'institution_ids': ['https://openalex.org/I161296585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003898395', 'display_name': 'Masayuki Asakawa', 'orcid': 'https://orcid.org/0000-0002-5443-3149'}, 'institutions': [{'id': 'https://openalex.org/I158929114', 'display_name': 'Tokyo Medical University', 'ror': 'https://ror.org/00k5j5c86', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I158929114']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masayuki Asakawa', 'raw_affiliation_strings': ['*Intractable Immune System Disease Research Center and', '†Department of Immunology, Tokyo Medical University, Tokyo, Japan; and'], 'affiliations': [{'raw_affiliation_string': '†Department of Immunology, Tokyo Medical University, Tokyo, Japan; and', 'institution_ids': ['https://openalex.org/I158929114']}, {'raw_affiliation_string': '*Intractable Immune System Disease Research Center and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082485668', 'display_name': 'Sadahiro Kamiya', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I158929114', 'display_name': 'Tokyo Medical University', 'ror': 'https://ror.org/00k5j5c86', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I158929114']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Sadahiro Kamiya', 'raw_affiliation_strings': ['*Intractable Immune System Disease Research Center and', '†Department of Immunology, Tokyo Medical University, Tokyo, Japan; and'], 'affiliations': [{'raw_affiliation_string': '*Intractable Immune System Disease Research Center and', 'institution_ids': []}, {'raw_affiliation_string': '†Department of Immunology, Tokyo Medical University, Tokyo, Japan; and', 'institution_ids': ['https://openalex.org/I158929114']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108432702', 'display_name': 'Junichiro Mizuguchi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I158929114', 'display_name': 'Tokyo Medical University', 'ror': 'https://ror.org/00k5j5c86', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I158929114']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Junichiro Mizuguchi', 'raw_affiliation_strings': ['*Intractable Immune System Disease Research Center and', '†Department of Immunology, Tokyo Medical University, Tokyo, Japan; and'], 'affiliations': [{'raw_affiliation_string': '*Intractable Immune System Disease Research Center and', 'institution_ids': []}, {'raw_affiliation_string': '†Department of Immunology, Tokyo Medical University, Tokyo, Japan; and', 'institution_ids': ['https://openalex.org/I158929114']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001884814', 'display_name': 'Takayuki Yoshimoto', 'orcid': 'https://orcid.org/0000-0002-2847-0341'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Takayuki Yoshimoto', 'raw_affiliation_strings': ['*Intractable Immune System Disease Research Center and'], 'affiliations': [{'raw_affiliation_string': '*Intractable Immune System Disease Research Center and', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.684, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 187, 'citation_normalized_percentile': {'value': 0.999891, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '175', 'issue': '3', 'first_page': '1686', 'last_page': '1693'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/granzyme-a', 'display_name': 'Granzyme A', 'score': 0.7112507}, {'id': 'https://openalex.org/keywords/granzyme', 'display_name': 'Granzyme', 'score': 0.5132694}], 'concepts': [{'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.75704724}, {'id': 'https://openalex.org/C2779968557', 'wikidata': 'https://www.wikidata.org/wiki/Q12646459', 'display_name': 'Granzyme A', 'level': 5, 'score': 0.7112507}, {'id': 'https://openalex.org/C2780380082', 'wikidata': 'https://www.wikidata.org/wiki/Q12646460', 'display_name': 'Granzyme B', 'level': 4, 'score': 0.7041808}, {'id': 'https://openalex.org/C2776062744', 'wikidata': 'https://www.wikidata.org/wiki/Q21103279', 'display_name': 'Perforin', 'level': 4, 'score': 0.67153955}, {'id': 'https://openalex.org/C129374314', 'wikidata': 'https://www.wikidata.org/wiki/Q909381', 'display_name': 'Interleukin 21', 'level': 4, 'score': 0.63670987}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.51508826}, {'id': 'https://openalex.org/C183193105', 'wikidata': 'https://www.wikidata.org/wiki/Q425068', 'display_name': 'Granzyme', 'level': 5, 'score': 0.5132694}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.48561326}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.4837613}, {'id': 'https://openalex.org/C149532602', 'wikidata': 'https://www.wikidata.org/wiki/Q2409681', 'display_name': 'Interleukin 12', 'level': 4, 'score': 0.44557336}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3755998}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3634386}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.28767306}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.18290138}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.16629893}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.04943168}], 'mesh': [{'descriptor_ui': 'D000276', 'descriptor_name': 'Adjuvants, Immunologic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D003602', 'descriptor_name': 'Cytotoxicity, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007378', 'descriptor_name': 'Interleukins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000276', 'descriptor_name': 'Adjuvants, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D003602', 'descriptor_name': 'Cytotoxicity, Immunologic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004357', 'descriptor_name': 'Drug Synergism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053804', 'descriptor_name': 'Granzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D018664', 'descriptor_name': 'Interleukin-12', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018664', 'descriptor_name': 'Interleukin-12', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007378', 'descriptor_name': 'Interleukins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007378', 'descriptor_name': 'Interleukins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008894', 'descriptor_name': 'Milk Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008894', 'descriptor_name': 'Milk Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054353', 'descriptor_name': 'Perforin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052899', 'descriptor_name': 'Pore Forming Cytotoxic Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018123', 'descriptor_name': 'Receptors, Interleukin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018123', 'descriptor_name': 'Receptors, Interleukin', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D053707', 'descriptor_name': 'Receptors, Interleukin-12', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016192', 'descriptor_name': 'Resting Phase, Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016192', 'descriptor_name': 'Resting Phase, Cell Cycle', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D050794', 'descriptor_name': 'STAT1 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050795', 'descriptor_name': 'STAT2 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050797', 'descriptor_name': 'STAT4 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050799', 'descriptor_name': 'STAT5 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020825', 'descriptor_name': 'T-Box Domain Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D050378', 'descriptor_name': 'T-Lymphocytes, Regulatory', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.175.3.1686', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/175/3/1686/1205773/1686.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16034109', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.175.3.1686', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/175/3/1686/1205773/1686.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1488600638', 'https://openalex.org/W1543188088', 'https://openalex.org/W1549692527', 'https://openalex.org/W1583209620', 'https://openalex.org/W1589212151', 'https://openalex.org/W1881674564', 'https://openalex.org/W1928985210', 'https://openalex.org/W1967176093', 'https://openalex.org/W1967261754', 'https://openalex.org/W1975601462', 'https://openalex.org/W1986370046', 'https://openalex.org/W2003182569', 'https://openalex.org/W2012628280', 'https://openalex.org/W2016956768', 'https://openalex.org/W2063053561', 'https://openalex.org/W2073242835', 'https://openalex.org/W2090831287', 'https://openalex.org/W2102810679', 'https://openalex.org/W2111980183', 'https://openalex.org/W2119319172', 'https://openalex.org/W2119986617', 'https://openalex.org/W2122506044', 'https://openalex.org/W2128475635', 'https://openalex.org/W2129292145', 'https://openalex.org/W2152108124', 'https://openalex.org/W2166182274', 'https://openalex.org/W2170904230'], 'related_works': ['https://openalex.org/W4214634819', 'https://openalex.org/W3032016103', 'https://openalex.org/W2107858772', 'https://openalex.org/W2083502121', 'https://openalex.org/W2068005505', 'https://openalex.org/W1991773024', 'https://openalex.org/W1991275224', 'https://openalex.org/W1986880637', 'https://openalex.org/W1958134254', 'https://openalex.org/W150405246'], 'abstract_inverted_index': {'Abstract': [0], 'IL-27': [1, 24, 61, 78, 109, 124, 202, 230], 'is': [2, 31], 'a': [3, 10, 26, 71], 'novel': [4], 'IL-12': [5, 115, 160, 189], 'family': [6], 'member': [7], 'that': [8, 23, 98, 229], 'plays': [9], 'role': [11], 'in': [12, 48, 57, 101, 238], 'the': [13, 56, 88, 140, 205], 'early': [14], 'regulation': [15], 'of': [16, 60, 66, 90, 99, 118, 127, 142, 166, 195, 207, 246], 'Th1': [17], 'initiation.': [18], 'We': [19], 'have': [20], 'recently': [21], 'demonstrated': [22], 'has': [25, 40], 'potent': [27], 'antitumor': [28], 'activity,': [29], 'which': [30], 'mainly': [32], 'mediated': [33], 'through': [34], 'CD8+': [35, 63, 103, 120, 147, 176, 235], 'T': [36, 64, 76, 104, 121, 129, 148, 177, 212, 236], 'cells,': [37, 77, 149, 178], 'and': [38, 84, 86, 93, 96, 116, 138, 171, 199, 240, 243], 'also': [39], 'an': [41], 'adjuvant': [42], 'activity': [43], 'to': [44, 74], 'induce': [45], 'epitope-specific': [46], 'CTL': [47, 208, 247], 'vivo.': [49], 'In': [50, 70, 144, 173], 'this': [51], 'study,': [52], 'we': [53], 'further': [54], 'investigated': [55], 'vitro': [58], 'effect': [59], 'on': [62, 233], 'cells': [65, 105, 132, 137, 215, 220, 237], 'mouse': [67], 'spleen': [68, 131, 136, 214, 219], 'cells.': [69, 122], 'manner': [72], 'similar': [73], 'CD4+': [75, 128, 211], 'activated': [79], 'STAT1,': [80], '-2,': [81], '-3,': [82], '-4,': [83], '-5,': [85], 'augmented': [87, 139, 204], 'expression': [89, 165, 194], 'T-bet,': [91, 167], 'IL-12Rβ2,': [92, 168, 196], 'granzyme': [94, 169, 197, 223, 250], 'B,': [95, 170, 198], 'slightly': [97], 'perforin': [100], 'naive': [102, 119, 146, 175, 234], 'stimulated': [106, 133, 216], 'with': [107, 114, 159, 163, 188, 192, 221, 248], 'anti-CD3.': [108], 'induced': [110], 'synergistic': [111, 156, 185], 'IFN-γ': [112, 157, 186], 'production': [113, 158, 187], 'proliferation': [117, 126, 151, 180], 'Moreover,': [123], 'enhanced': [125, 249], 'cell-depleted': [130, 213], 'by': [134, 217], 'allogeneic': [135, 218], 'generation': [141, 206, 245], 'CTL.': [143], 'STAT1-deficient': [145], 'IL-27-induced': [150, 179], 'was': [152, 161, 181, 190], 'not': [153], 'reduced,': [154, 183], 'but': [155, 184], 'diminished': [162, 191], 'decreased': [164, 193], 'perforin.': [172, 200], 'T-bet-deficient': [174, 210], 'hardly': [182], 'However,': [201], 'still': [203], 'from': [209], 'increased': [222], 'B': [224, 251], 'expression.': [225, 252], 'These': [226], 'results': [227], 'suggest': [228], 'directly': [231], 'acts': [232], 'T-bet-dependent': [239], '-independent': [241], 'manners': [242], 'augments': [244]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2159497705', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 20}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 17}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-12-12T06:54:13.424997', 'created_date': '2016-06-24'}