Proteome Analysis of Hepatocellular Carcinoma by Two-dimensional Difference Gel Electrophoresis

Name: Work Video:
Duration: 3 min 30 s
Wei Sun; Baocai Xing; Yi Sun; Xiaojuan Du; Min Lu; Chunyi Hao; Zhuang Lu; Wei Mi; Songfeng Wu; Handong Wei; Xueqin Gao; Yunping Zhu; Ying Jiang; Xiaohong Qian; Fuchu He
{'id': 'https://openalex.org/W2159492800', 'doi': 'https://doi.org/10.1074/mcp.m600449-mcp200', 'title': 'Proteome Analysis of Hepatocellular Carcinoma by Two-dimensional Difference Gel Electrophoresis', 'display_name': 'Proteome Analysis of Hepatocellular Carcinoma by Two-dimensional Difference Gel Electrophoresis', 'publication_year': 2007, 'publication_date': '2007-07-13', 'ids': {'openalex': 'https://openalex.org/W2159492800', 'doi': 'https://doi.org/10.1074/mcp.m600449-mcp200', 'mag': '2159492800', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17627933'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m600449-mcp200', 'pdf_url': 'http://www.mcponline.org/article/S1535947620319514/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.mcponline.org/article/S1535947620319514/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102020294', 'display_name': 'Wei Sun', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210149540', 'display_name': 'Beijing Proteome Research Center', 'ror': 'https://ror.org/05pp5b412', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210149540']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Sun', 'raw_affiliation_strings': ['State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China', 'institution_ids': ['https://openalex.org/I4210149540']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101593595', 'display_name': 'Baocai Xing', 'orcid': 'https://orcid.org/0000-0002-9908-8588'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4210093964', 'display_name': 'Peking University Cancer Hospital', 'ror': 'https://ror.org/00nyxxr91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093964']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Baocai Xing', 'raw_affiliation_strings': ['Beijing Cancer Hospital, Beijing 100036, China'], 'affiliations': [{'raw_affiliation_string': 'Beijing Cancer Hospital, Beijing 100036, China', 'institution_ids': ['https://openalex.org/I20231570', 'https://openalex.org/I4210093964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027499108', 'display_name': 'Yi Sun', 'orcid': 'https://orcid.org/0000-0002-0194-2476'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4210093964', 'display_name': 'Peking University Cancer Hospital', 'ror': 'https://ror.org/00nyxxr91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093964']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yi Sun', 'raw_affiliation_strings': ['Beijing Cancer Hospital, Beijing 100036, China'], 'affiliations': [{'raw_affiliation_string': 'Beijing Cancer Hospital, Beijing 100036, China', 'institution_ids': ['https://openalex.org/I20231570', 'https://openalex.org/I4210093964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032901555', 'display_name': 'Xiaojuan Du', 'orcid': 'https://orcid.org/0000-0002-0108-511X'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaojuan Du', 'raw_affiliation_strings': ['Department of Cell Biology, Peking University Health Science Center, Beijing 100083, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Peking University Health Science Center, Beijing 100083, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102994204', 'display_name': 'Min Lu', 'orcid': 'https://orcid.org/0000-0003-0636-2240'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Min Lu', 'raw_affiliation_strings': ['Department of Pathology, Peking University Health Science Center, Beijing 100083, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Peking University Health Science Center, Beijing 100083, China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086047610', 'display_name': 'Chunyi Hao', 'orcid': 'https://orcid.org/0000-0002-1233-1689'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4210093964', 'display_name': 'Peking University Cancer Hospital', 'ror': 'https://ror.org/00nyxxr91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093964']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chunyi Hao', 'raw_affiliation_strings': ['Beijing Cancer Hospital, Beijing 100036, China'], 'affiliations': [{'raw_affiliation_string': 'Beijing Cancer Hospital, Beijing 100036, China', 'institution_ids': ['https://openalex.org/I20231570', 'https://openalex.org/I4210093964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017040292', 'display_name': 'Zhuang Lu', 'orcid': 'https://orcid.org/0000-0002-1826-363X'}, 'institutions': [{'id': 'https://openalex.org/I4210149540', 'display_name': 'Beijing Proteome Research Center', 'ror': 'https://ror.org/05pp5b412', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210149540']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhuang Lu', 'raw_affiliation_strings': ['State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China', 'institution_ids': ['https://openalex.org/I4210149540']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049790623', 'display_name': 'Wei Mi', 'orcid': 'https://orcid.org/0000-0002-2845-4608'}, 'institutions': [{'id': 'https://openalex.org/I4210149540', 'display_name': 'Beijing Proteome Research Center', 'ror': 'https://ror.org/05pp5b412', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210149540']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Mi', 'raw_affiliation_strings': ['State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China', 'institution_ids': ['https://openalex.org/I4210149540']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102717235', 'display_name': 'Songfeng Wu', 'orcid': 'https://orcid.org/0009-0004-6355-741X'}, 'institutions': [{'id': 'https://openalex.org/I4210149540', 'display_name': 'Beijing Proteome Research Center', 'ror': 'https://ror.org/05pp5b412', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210149540']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Songfeng Wu', 'raw_affiliation_strings': ['State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China', 'institution_ids': ['https://openalex.org/I4210149540']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100887735', 'display_name': 'Handong Wei', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210149540', 'display_name': 'Beijing Proteome Research Center', 'ror': 'https://ror.org/05pp5b412', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210149540']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Handong Wei', 'raw_affiliation_strings': ['State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China', 'institution_ids': ['https://openalex.org/I4210149540']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101526716', 'display_name': 'Xueqin Gao', 'orcid': 'https://orcid.org/0000-0001-5833-1548'}, 'institutions': [{'id': 'https://openalex.org/I4210149540', 'display_name': 'Beijing Proteome Research Center', 'ror': 'https://ror.org/05pp5b412', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210149540']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xue Gao', 'raw_affiliation_strings': ['State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China', 'institution_ids': ['https://openalex.org/I4210149540']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100765277', 'display_name': 'Yunping Zhu', 'orcid': 'https://orcid.org/0000-0002-7320-7411'}, 'institutions': [{'id': 'https://openalex.org/I4210149540', 'display_name': 'Beijing Proteome Research Center', 'ror': 'https://ror.org/05pp5b412', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210149540']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yunping Zhu', 'raw_affiliation_strings': ['State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China', 'institution_ids': ['https://openalex.org/I4210149540']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065776852', 'display_name': 'Ying Jiang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210149540', 'display_name': 'Beijing Proteome Research Center', 'ror': 'https://ror.org/05pp5b412', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210149540']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ying Jiang', 'raw_affiliation_strings': ['State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China', 'institution_ids': ['https://openalex.org/I4210149540']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100522505', 'display_name': 'Xiaohong Qian', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210149540', 'display_name': 'Beijing Proteome Research Center', 'ror': 'https://ror.org/05pp5b412', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210149540']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaohong Qian', 'raw_affiliation_strings': ['State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China', 'institution_ids': ['https://openalex.org/I4210149540']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5091436402', 'display_name': 'Fuchu He', 'orcid': 'https://orcid.org/0000-0002-8571-2351'}, 'institutions': [{'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}, {'id': 'https://openalex.org/I4210149540', 'display_name': 'Beijing Proteome Research Center', 'ror': 'https://ror.org/05pp5b412', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I4210149540']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Fuchu He', 'raw_affiliation_strings': ['Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China', 'State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China', 'institution_ids': ['https://openalex.org/I24943067']}, {'raw_affiliation_string': 'State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P.R. China', 'institution_ids': ['https://openalex.org/I4210149540']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5091436402'], 'corresponding_institution_ids': ['https://openalex.org/I24943067', 'https://openalex.org/I4210149540'], 'apc_list': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'apc_paid': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'fwci': 14.959, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 244, 'citation_normalized_percentile': {'value': 0.99997, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '6', 'issue': '10', 'first_page': '1798', 'last_page': '1808'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10519', 'display_name': 'Advanced Proteomics Techniques and Applications', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proteome', 'display_name': 'Proteome', 'score': 0.6322955}, {'id': 'https://openalex.org/keywords/hepatocellular-adenoma', 'display_name': 'Hepatocellular adenoma', 'score': 0.5880752}, {'id': 'https://openalex.org/keywords/prohibitin', 'display_name': 'Prohibitin', 'score': 0.51484627}, {'id': 'https://openalex.org/keywords/difference-gel-electrophoresis', 'display_name': 'Difference gel electrophoresis', 'score': 0.43083897}], 'concepts': [{'id': 'https://openalex.org/C2778019345', 'wikidata': 'https://www.wikidata.org/wiki/Q1148337', 'display_name': 'Hepatocellular carcinoma', 'level': 2, 'score': 0.70547837}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.695216}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.637091}, {'id': 'https://openalex.org/C104397665', 'wikidata': 'https://www.wikidata.org/wiki/Q860947', 'display_name': 'Proteome', 'level': 2, 'score': 0.6322955}, {'id': 'https://openalex.org/C2778141868', 'wikidata': 'https://www.wikidata.org/wiki/Q1172076', 'display_name': 'Hepatocellular adenoma', 'level': 3, 'score': 0.5880752}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5449816}, {'id': 'https://openalex.org/C2775894526', 'wikidata': 'https://www.wikidata.org/wiki/Q2112279', 'display_name': 'Prohibitin', 'level': 3, 'score': 0.51484627}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.5057063}, {'id': 'https://openalex.org/C205260736', 'wikidata': 'https://www.wikidata.org/wiki/Q418939', 'display_name': 'Heat shock protein', 'level': 3, 'score': 0.46085232}, {'id': 'https://openalex.org/C178596410', 'wikidata': 'https://www.wikidata.org/wiki/Q5275273', 'display_name': 'Difference gel electrophoresis', 'level': 4, 'score': 0.43083897}, {'id': 'https://openalex.org/C53345823', 'wikidata': 'https://www.wikidata.org/wiki/Q5531554', 'display_name': 'Gene isoform', 'level': 3, 'score': 0.4135528}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.40700835}, {'id': 'https://openalex.org/C46111723', 'wikidata': 'https://www.wikidata.org/wiki/Q471857', 'display_name': 'Proteomics', 'level': 3, 'score': 0.34523422}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2786352}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.130433}], 'mesh': [{'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D015180', 'descriptor_name': 'Electrophoresis, Gel, Two-Dimensional', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D020543', 'descriptor_name': 'Proteome', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000642', 'descriptor_name': 'Ammonia-Lyases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000642', 'descriptor_name': 'Ammonia-Lyases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015180', 'descriptor_name': 'Electrophoresis, Gel, Two-Dimensional', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006360', 'descriptor_name': 'Heat-Shock Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006360', 'descriptor_name': 'Heat-Shock Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006360', 'descriptor_name': 'Heat-Shock Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034441', 'descriptor_name': 'Heterogeneous-Nuclear Ribonucleoproteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D034441', 'descriptor_name': 'Heterogeneous-Nuclear Ribonucleoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D034441', 'descriptor_name': 'Heterogeneous-Nuclear Ribonucleoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020543', 'descriptor_name': 'Proteome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015203', 'descriptor_name': 'Reproducibility of Results', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019032', 'descriptor_name': 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013347', 'descriptor_name': 'Subcellular Fractions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m600449-mcp200', 'pdf_url': 'http://www.mcponline.org/article/S1535947620319514/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17627933', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m600449-mcp200', 'pdf_url': 'http://www.mcponline.org/article/S1535947620319514/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.81}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 68, 'referenced_works': ['https://openalex.org/W1841796848', 'https://openalex.org/W1892965527', 'https://openalex.org/W1968316735', 'https://openalex.org/W1970240865', 'https://openalex.org/W1973162980', 'https://openalex.org/W1973708209', 'https://openalex.org/W1980804108', 'https://openalex.org/W1984945969', 'https://openalex.org/W1986677429', 'https://openalex.org/W1994657678', 'https://openalex.org/W1998495520', 'https://openalex.org/W2000584362', 'https://openalex.org/W2003107065', 'https://openalex.org/W2015787260', 'https://openalex.org/W2018182904', 'https://openalex.org/W2019773602', 'https://openalex.org/W2021812827', 'https://openalex.org/W2025130035', 'https://openalex.org/W2026772743', 'https://openalex.org/W2027003058', 'https://openalex.org/W2027027798', 'https://openalex.org/W2032125539', 'https://openalex.org/W2032352097', 'https://openalex.org/W2039833103', 'https://openalex.org/W2046289462', 'https://openalex.org/W2049789461', 'https://openalex.org/W2053166899', 'https://openalex.org/W2054466780', 'https://openalex.org/W2058265375', 'https://openalex.org/W2059294718', 'https://openalex.org/W2061239746', 'https://openalex.org/W2062189636', 'https://openalex.org/W2065481063', 'https://openalex.org/W2068264995', 'https://openalex.org/W2068482643', 'https://openalex.org/W2072681755', 'https://openalex.org/W2072939418', 'https://openalex.org/W2074164438', 'https://openalex.org/W2078487586', 'https://openalex.org/W2086314938', 'https://openalex.org/W2087746647', 'https://openalex.org/W2087787518', 'https://openalex.org/W2091658923', 'https://openalex.org/W2095495549', 'https://openalex.org/W2098412336', 'https://openalex.org/W2098627844', 'https://openalex.org/W2099046152', 'https://openalex.org/W2100070712', 'https://openalex.org/W2103348422', 'https://openalex.org/W2108860654', 'https://openalex.org/W2114676845', 'https://openalex.org/W2122338290', 'https://openalex.org/W2126762966', 'https://openalex.org/W2127303413', 'https://openalex.org/W2128415167', 'https://openalex.org/W2132955929', 'https://openalex.org/W2137234652', 'https://openalex.org/W2138016026', 'https://openalex.org/W2139574601', 'https://openalex.org/W2160173410', 'https://openalex.org/W2162415760', 'https://openalex.org/W2165391029', 'https://openalex.org/W2167044450', 'https://openalex.org/W2176821105', 'https://openalex.org/W2319730502', 'https://openalex.org/W2321796693', 'https://openalex.org/W2374869013', 'https://openalex.org/W4377077071'], 'related_works': ['https://openalex.org/W2379013558', 'https://openalex.org/W2151501729', 'https://openalex.org/W2112716230', 'https://openalex.org/W2103391693', 'https://openalex.org/W2069003184', 'https://openalex.org/W2056003560', 'https://openalex.org/W2055819364', 'https://openalex.org/W2045067633', 'https://openalex.org/W2036791348', 'https://openalex.org/W2004493637'], 'abstract_inverted_index': {'Hepatocellular': [0, 250, 1151], 'carcinoma': [1, 251, 1073, 1311, 1416, 1608, 1695, 1862, 1901, 1938, 2014, 2227, 2432, 2519, 2558, 2855, 3589, 4101, 4264], '(HCC)': [2, 252, 1074], 'is': [3, 15, 253, 265, 502, 536, 692, 741, 808, 1075, 1084, 1117, 1717, 1752, 2260, 2280, 2285, 2717, 3136, 3164, 3408, 3536, 3799, 3951], 'a': [4, 254, 507, 537, 626, 875, 1012, 1124, 1935, 2056, 2271, 2286, 2514, 2718, 3170, 3235, 3283, 3339, 3437, 3505, 3537, 3748], 'highly': [5, 255], 'malignant': [6, 256, 2266], 'tumor,': [7, 257], 'and': [8, 43, 101, 119, 160, 194, 207, 232, 258, 293, 351, 369, 410, 444, 457, 482, 516, 542, 554, 638, 676, 688, 737, 774, 803, 832, 878, 937, 978, 1038, 1059, 1083, 1100, 1130, 1154, 1166, 1198, 1266, 1304, 1321, 1391, 1423, 1500, 1535, 1619, 1660, 1673, 1726, 1746, 1770, 1819, 1830, 1905, 2031, 2113, 2154, 2275, 2277, 2319, 2382, 2433, 2578, 2643, 2727, 2749, 2919, 2930, 2955, 2990, 2993, 3003, 3077, 3091, 3147, 3193, 3215, 3246, 3269, 3345, 3348, 3363, 3372, 3543, 3562, 3574, 3580, 3671, 3680, 3701, 3723, 3735, 3742, 3791, 3819, 3839, 3869, 3901, 3964, 3972, 4043, 4108, 4125, 4131, 4169, 4211, 4217, 4271, 4295], 'chronic': [9, 259, 1128, 2316, 2474, 2527], 'infection': [10, 260, 1790], 'with': [11, 261, 646, 674, 733, 1317, 1448, 1573, 1740, 1788, 1868, 2108, 2225, 2270, 2305, 2376, 2526, 2627, 2679, 2778, 2856, 2878, 2922, 3242, 3350, 3474, 3731, 3953], 'hepatitis': [12, 51, 262, 301, 586, 590, 1263, 1267, 1373, 2475, 2620, 3039, 3171], 'B': [13, 52, 263, 302, 587, 1264, 1374, 1970, 2621, 3172], 'virus': [14, 264, 3173], 'one': [16, 266, 657, 863, 1076, 1088, 2261, 4215], 'of': [17, 60, 95, 117, 127, 175, 191, 247, 267, 310, 345, 367, 377, 425, 441, 497, 513, 524, 529, 540, 658, 702, 719, 752, 780, 827, 859, 917, 969, 1026, 1048, 1077, 1127, 1169, 1180, 1224, 1260, 1308, 1372, 1379, 1413, 1491, 1508, 1538, 1564, 1567, 1606, 1650, 1708, 1731, 1736, 1743, 1784, 1797, 1806, 1809, 1822, 1840, 1859, 1897, 1907, 1934, 1966, 2011, 2051, 2099, 2151, 2160, 2178, 2221, 2262, 2288, 2301, 2308, 2315, 2343, 2349, 2369, 2372, 2387, 2430, 2466, 2470, 2473, 2513, 2517, 2524, 2554, 2616, 2685, 2731, 2746, 2783, 2853, 2858, 2884, 2911, 2940, 2950, 2981, 2996, 3029, 3055, 3085, 3132, 3142, 3169, 3197, 3203, 3233, 3264, 3266, 3282, 3306, 3323, 3353, 3360, 3378, 3383, 3402, 3443, 3503, 3507, 3533, 3540, 3564, 3578, 3608, 3619, 3629, 3669, 3698, 3708, 3717, 3721, 3753, 3772, 3806, 3815, 3824, 3837, 3896, 3926, 3933, 3961, 3989, 4031, 4066, 4098, 4122, 4132, 4159, 4185, 4197, 4203, 4205, 4261, 4287], 'its': [18, 268, 2434], 'major': [19, 269], 'risk': [20, 270], 'factors.': [21, 271], 'To': [22, 272], 'identify': [23, 273, 2103], 'the': [24, 37, 96, 139, 143, 186, 189, 241, 245, 274, 287, 346, 389, 393, 436, 439, 491, 495, 659, 667, 684, 700, 717, 734, 796, 857, 915, 1078, 1140, 1147, 1167, 1181, 1565, 1715, 1722, 1733, 1741, 1807, 1820, 1898, 1908, 2161, 2263, 2340, 2347, 2471, 2639, 2644, 2660, 2686, 2695, 2713, 2744, 2758, 2763, 2894, 2909, 2926, 2982, 2997, 3056, 3081, 3167, 3195, 3201, 3204, 3280, 3324, 3351, 3384, 3397, 3400, 3406, 3470, 3576, 3614, 3620, 3630, 3637, 3696, 3709, 3714, 3751, 3782, 3786, 3804, 3810, 3822, 3827, 3842, 3894, 3906, 3958, 4032, 4064, 4120, 4183, 4228, 4237, 4297], 'proteins': [25, 40, 109, 121, 178, 275, 290, 359, 371, 428, 560, 1049, 1614, 1821, 1910, 2642, 2662, 2681, 2693, 2701, 2971, 3106, 3245, 3386, 3403, 3611, 3622, 3632, 3725, 3930], 'involved': [26, 137, 243, 276, 387, 493, 3368, 3780, 4035], 'in': [27, 41, 72, 112, 122, 138, 142, 147, 153, 183, 199, 212, 229, 244, 277, 291, 322, 362, 372, 388, 392, 397, 403, 433, 449, 462, 479, 494, 522, 527, 561, 663, 683, 694, 821, 829, 945, 1016, 1050, 1120, 1171, 1192, 1195, 1202, 1455, 1457, 1543, 1609, 1692, 1724, 2060, 2111, 2157, 2180, 2246, 2254, 2556, 2663, 2674, 2698, 2739, 2897, 2901, 2945, 2961, 2975, 3061, 3099, 3128, 3212, 3272, 3279, 3333, 3341, 3369, 3387, 3392, 3396, 3624, 3676, 3713, 3726, 3756, 3781, 3785, 3795, 3809, 3826, 3831, 3834, 3872, 3889, 3905, 3969, 3992, 4036, 4039, 4069, 4127, 4134, 4187, 4291], 'HCC': [28, 54, 113, 132, 148, 200, 214, 230, 248, 278, 304, 363, 382, 398, 450, 464, 480, 498, 1116, 1135, 1447, 1763, 1785, 1811, 1841, 2259, 2320, 2755, 2784, 2898, 2912, 2931, 2941, 2948, 2962, 2976, 3063, 3101, 3275, 3471, 3796, 3973, 4071, 4130, 4188, 4199, 4204, 4293], 'carcinogenesis,': [29, 279, 3472], 'we': [30, 225, 280, 475, 1774, 2966], 'used': [31, 281, 572, 631, 693, 1775, 4193], 'two-dimensional': [32, 282, 575, 712, 770, 974, 1322, 1419, 1497, 1656, 1864, 2380, 4104, 4165, 4267], 'fluorescence': [33, 283], 'DIGE': [34, 284, 651, 669, 747, 802, 872, 1777, 2760], 'to': [35, 285, 505, 550, 942, 1123, 1721, 1756, 1778, 2102, 2185, 2217, 2299, 2477, 2653, 2722, 3096, 3330, 3405], 'study': [36, 286, 1858, 3728, 3888], 'differentially': [38, 288, 1814, 2764], 'expressed': [39, 289, 1815, 2765], 'tumor': [42, 73, 221, 292, 323, 471, 1381, 1494, 1793, 2267, 2748, 3508, 3649], 'adjacent': [44, 294], 'nontumor': [45, 295, 2750], 'tissue': [46, 296, 1495, 1539, 1696, 1782, 2716], 'samples.': [47, 114, 297, 364, 566], 'Samples': [48, 298], 'from': [49, 164, 299, 414, 1786, 2253, 2374, 2619, 2682, 2753], '12': [50, 300, 2754], 'virus-associated': [53, 303, 1269, 1375], 'patients': [55, 305, 1737, 2375, 2525, 2756], 'were': [56, 63, 78, 89, 104, 110, 145, 162, 306, 313, 328, 339, 354, 360, 395, 412, 1795, 1817, 1824, 2771, 2934, 2973, 3094, 3121, 3328, 3390, 3633, 3793, 4194], 'analyzed.': [57, 307], 'A': [58, 308, 2337, 2551, 3887], 'total': [59, 309], '61': [61, 311], 'spots': [62, 77, 312, 327, 1816], 'significantly': [64, 314, 2669, 3468], 'up-regulated': [65, 315, 2916, 2974, 3098, 3127, 3332], '(ratio': [66, 80, 316, 330], '≥': [67, 317], '2,': [68, 318], 'p': [69, 83, 319, 333], '≤': [70, 81, 84, 320, 331, 334], '0.01)': [71, 321], 'samples,': [74, 215, 324, 465], 'whereas': [75, 107, 325, 357, 4138], '158': [76, 326], 'down-regulated': [79, 146, 329, 396, 3385, 3631, 3794], '−2,': [82, 332], '0.01).': [85, 335], 'Seventy-one': [86, 336], 'gene': [87, 156, 337, 406, 1014, 2163, 2769, 2779, 2850], 'products': [88, 338, 2770], 'identified': [90, 163, 340, 413, 2559, 2935, 2967, 3150, 3192, 3623], 'among': [91, 341, 2303], 'these': [92, 123, 176, 233, 342, 373, 426, 483, 744, 866, 2732, 3086, 3104, 3355, 4067, 4288], 'spots.': [93, 343], 'Members': [94, 344], 'heat': [97, 347, 617, 2969, 3030, 3068, 3243], 'shock': [98, 348, 618, 2970, 3031, 3069, 3244], 'protein': [99, 193, 220, 349, 443, 470, 514, 533, 922, 2059, 2522, 2646, 2766, 2938, 3032, 3072, 3239, 3640], '70': [100, 213, 350, 463, 2946, 2954, 2984, 3033, 3058, 3208, 3268, 3326, 3362], '90': [102, 352, 2956, 2999, 3002, 3124, 3217, 3270, 3364], 'families': [103, 353, 3271, 3365], 'simultaneously': [105, 355], 'up-regulated,': [106, 356], 'metabolism-associated': [108, 358], 'decreased': [111, 361], 'The': [115, 365, 1813, 2149, 3433, 3500, 3530, 3719, 3813, 4190], 'down-regulation': [116, 366, 3720, 3814, 4121], 'mitochondrial': [118, 368, 3610, 3722, 3899, 3929], 'peroxisomal': [120, 370, 3634, 3638, 3672, 3724], 'results': [124, 234, 374, 484, 1710, 2179, 3356, 3833, 4234], 'suggested': [125, 375, 3357, 3463], 'loss': [126, 376], 'special': [128, 378], 'organelle': [129, 379, 3700, 3754], 'functions': [130, 380], 'during': [131, 381, 3469], 'carcinogenesis.': [133, 249, 383, 499, 2913], 'Four': [134, 384], 'metabolic': [135, 385, 804, 833, 3710, 3778], 'enzymes': [136, 386, 3675, 3779, 4034, 4068, 4290], 'methylation': [140, 390, 3783, 3811], 'cycle': [141, 391, 3784], 'liver': [144, 394, 1493, 2109, 2309, 2317, 2528, 2751, 3681, 3870, 3907, 4041], 'tissues,': [149, 231, 399, 481, 2899, 2977, 3064, 3102], 'indicating': [150, 400], 'S-adenosylmethionine': [151, 401, 3807], 'deficiency': [152, 402, 3830, 3895], 'HCC.': [154, 184, 404, 434, 1187, 1439, 3117, 3130, 3335, 3718], 'Two': [155, 405], 'products,': [157, 407], 'glyceraldehyde-3-phosphate': [158, 408, 600], 'dehydrogenase': [159, 409, 1570], 'formimidoyltransferase-cyclodeaminase,': [161, 411], 'inversely': [165, 415], 'altered': [166, 416, 3467], 'spots,': [167, 417, 2767], 'suggesting': [168, 216, 418, 466, 3103], 'that': [169, 419, 547, 628, 697, 740, 795, 2106, 2625, 2720, 2972, 3240, 3358, 3381, 3464, 3605, 3646, 3737, 3893, 3957], 'different': [170, 181, 420, 431, 671, 1193, 2313], 'isoforms': [171, 421], 'or': [172, 422, 563, 1450, 1803, 2256, 2655, 2665, 2677, 3114, 4200, 4221], 'post-translational': [173, 423], 'modifications': [174, 424], 'two': [177, 427, 562, 2915, 2994, 3084, 3105, 3122, 4218], 'might': [179, 429, 652, 3702, 4226], 'play': [180, 430], 'roles': [182, 432], 'For': [185, 435], 'first': [187, 437], 'time,': [188, 438], 'overexpression': [190, 440, 2220, 3196, 3263], 'Hcp70/Hsp90-organizing': [192, 442, 580], 'heterogeneous': [195, 445, 594, 4206], 'nuclear': [196, 446, 595], 'ribonucleoproteins': [197, 447], 'C1/C2': [198, 448], 'tissues': [201, 451, 1417, 2752, 4072, 4102, 4265, 4294], 'was': [202, 452, 625, 629, 2775, 3276, 3380, 3729], 'confirmed': [203, 453, 3575, 4296], 'by': [204, 209, 454, 459, 743, 800, 973, 1175, 1418, 1496, 1655, 1827, 1911, 2379, 2520, 2560, 2848, 2942, 3441, 3606, 4103, 4164, 4266], 'Western': [205, 455, 1828, 2879], 'blot': [206, 456, 1829, 2880], 'then': [208, 458], 'immunohistochemistry': [210, 460, 1831, 2943], 'staining': [211, 461, 756, 2944], 'their': [217, 467, 1620, 1709], 'potential': [218, 468, 718, 1380, 2706, 2937], 'as': [219, 469, 656, 950, 1139, 2055, 2244, 2312, 2583, 2650, 2936, 3036, 3138, 3151, 3558, 3931], 'markers.': [222, 472], 'In': [223, 473, 852, 1133, 1729, 2689, 2876, 3080, 3118, 3394], 'summary,': [224, 474], 'profiled': [226, 476], 'proteome': [227, 477, 1261, 2657, 2745, 3744, 4061], 'alterations': [228, 478, 1563, 2896, 3755, 4065, 4286], 'may': [235, 485, 2249, 2667, 2903, 3107, 3337, 3366, 3694, 3746], 'provide': [236, 486, 552], 'useful': [237, 487], 'insights': [238, 488], 'for': [239, 489, 510, 559, 632, 862, 914, 1086, 1103, 1506, 1749, 1761, 2291, 2339, 2346, 2351, 2428, 2468, 3038, 3111, 3156, 3166, 3560, 3587, 3706, 3750, 3803, 4230], 'understanding': [240, 490, 2908], 'mechanism': [242, 492, 2725, 2910, 3843], 'process': [246, 496], 'Proteomics': [500, 3586], 'analysis': [501, 523, 779, 880, 968, 1223, 1307, 1371, 1412, 1490, 1534, 1839, 1933, 2010, 2216, 2342, 2615, 3305, 3745, 4097, 4260], 'currently': [503], 'considered': [504, 655], 'be': [506, 654, 1712, 2186, 2668, 2710, 3097, 3109, 3331, 3367, 3704, 3747, 4227], 'powerful': [508], 'tool': [509], 'global': [511], 'evaluation': [512], 'expression,': [515], 'proteomics': [517, 633, 943, 1838, 2734, 3925], 'has': [518, 698, 792, 938, 1136, 1183, 2296, 2585, 3148, 3643], 'been': [519, 643, 793, 940, 1137, 1190, 1443, 1834, 2297, 2587, 3149, 3644], 'widely': [520, 630], 'applied': [521, 941, 2588], 'diseases,': [525, 2310], 'especially': [526, 1118], 'fields': [528], 'cancer': [530, 952, 972, 990, 1021, 1040, 1053, 1145, 2110, 3476, 3541, 3732], 'research.': [531, 634], 'Quantitative': [532], 'expression': [534, 557, 2780, 2851, 3991], 'profiling': [535, 544, 1605, 1691, 2423, 2465, 2523, 2781, 3028], 'crucial': [538], 'part': [539], 'proteomics,': [541], 'such': [543, 949, 2311, 2582], 'requires': [545], 'methods': [546, 1745], 'are': [548, 681, 1173, 2883, 3466, 3966, 4073], 'able': [549], 'efficiently': [551], 'accurate': [553, 876, 2891], 'reproducible': [555], 'differential': [556, 911, 1056], 'values': [558], 'more': [564, 874], 'biological': [565, 3477, 3733], 'Two-dimensional': [567, 649, 1894], 'electrophoresis': [568, 715, 773, 831, 913, 977, 1058, 1422, 1499, 1659, 1867, 1895, 2381, 4107, 4168, 4270], '(2DE)': [569], '1The': [570], 'abbreviations': [571], 'are:': [573], '2DE,': [574, 870], 'electrophoresis;': [576], '2D,': [577], 'two-dimensional;': [578], 'HOP,': [579, 3198, 3354], 'protein;': [581, 619], 'HCC,': [582, 1750, 3840, 4137], 'hepatocellular': [583, 1104, 1225, 1270, 1310, 1376, 1415, 1544, 1574, 1607, 1652, 1694, 1861, 1900, 1937, 1967, 2013, 2061, 2158, 2226, 2352, 2377, 2431, 2478, 2518, 2557, 2843, 2854, 3042, 3307, 3588, 3648, 3678, 3994, 4044, 4100, 4161, 4263], 'carcinoma;': [584], 'HBV,': [585], 'virus;': [588, 592], 'HCV,': [589], 'C': [591, 1268, 2476, 3040], 'hnRNP,': [593], 'ribonucleoprotein;': [596], 'TEMED,': [597], 'N,N,N′,N′-tetramethylethylenediamine;': [598], 'GAPDH,': [599], 'dehydrogenase;': [601], 'MAT,': [602, 3788, 3816, 3962, 4123], 'methionine': [603, 3875, 4037], 'adenosyltransferase;': [604], 'GNMT,': [605, 3789, 3817], 'glycine': [606], 'N-methyltransferase;': [607], 'BHMT,': [608, 3790, 3818, 3963, 4124], 'betaine-homocysteine': [609], 'S-methyltransferase;': [610], 'COMT,': [611, 3792], 'catechol': [612], 'O-methyltransferase;': [613], 'FTCD,': [614], 'formimidoyltransferase-cyclodeaminase;': [615], 'HSP,': [616], 'AdoMet,': [620], 'S-adenosylmethionine;': [621], 'GRP,': [622], 'glucose-regulated': [623], 'protein.': [624], 'technique': [627], 'However,': [635, 2638, 3320, 4060], 'intergel': [636, 703], 'variation': [637, 704], 'excessive': [639], 'time/labor': [640], 'costs': [641], 'have': [642, 1189, 1434, 1442, 1833, 2250, 2694, 2703, 2889], 'common': [644, 1080], 'problems': [645], 'standard': [647, 691], '2DE.': [648], '(2D)': [650], 'therefore': [653, 2715], 'most': [660, 1079, 1142, 1179, 2264, 2730], 'significant': [661, 2251], 'advances': [662], 'quantitative': [664, 822, 879, 1305], 'proteomics.': [665], 'Using': [666], '2D': [668, 686, 746, 801, 871, 910, 1776, 2759], 'approach,': [670], 'samples': [672, 1769, 1783, 1794, 2183, 4191], 'prelabeled': [673], 'mass-': [675], 'charge-matched': [677], 'fluorescent': [678], 'cyanine': [679], 'dyes': [680], 'co-separated': [682], 'same': [685], 'gel,': [687], 'an': [689, 1753, 1942, 2675, 3139, 3152, 3800], 'internal': [690], 'every': [695], 'gel': [696, 714, 772, 830, 976, 1057, 1421, 1498, 1658, 1866, 4106, 4167, 4269], 'negated': [699], 'problem': [701], '(1Van': [705], 'den': [706], 'Bergh': [707], 'G.': [708, 882, 1221, 1258, 1686, 2820, 2822, 3303, 3489, 3519, 3859], 'Arckens': [709], 'L.': [710, 1293, 1359, 1361, 1889, 2448, 2550, 3585, 3857, 4011], 'Fluorescent': [711], 'difference': [713, 771, 828, 975, 1420, 1657, 1865, 3340, 4105, 4166, 4268], 'unveils': [716], 'gel-based': [720], 'proteomics.Curr.': [721], 'Opin.': [722], 'Biotechnol.': [723], '2004;': [724, 981, 1329, 1702, 2023, 2231, 2630, 3449, 3545, 3592], '15:': [725], '38-43Crossref': [726], 'PubMed': [727, 786, 847, 934, 984, 1033, 1068, 1111, 1161, 1233, 1337, 1386, 1429, 1514, 1549, 1581, 1627, 1668, 1875, 1917, 1947, 1979, 2026, 2067, 2124, 2170, 2239, 2357, 2440, 2483, 2533, 2573, 2633, 2871, 3047, 3185, 3256, 3315, 3457, 3548, 3600, 3687, 3767, 3882, 3944, 4001, 4055, 4114, 4177, 4277], 'Scopus': [728, 787, 848, 985, 1034, 1069, 1112, 1162, 1234, 1338, 1387, 1430, 1515, 1550, 1582, 1628, 1669, 1876, 1918, 1948, 1980, 2027, 2068, 2125, 2171, 2240, 2358, 2441, 2484, 2534, 2574, 2634, 2872, 3048, 3186, 3257, 3316, 3458, 3549, 3601, 3688, 3768, 3883, 3945, 4002, 4056, 4115, 4178, 4278], '(166)': [729], 'Google': [730, 789, 850, 935, 987, 1036, 1071, 1114, 1164, 1236, 1277, 1340, 1389, 1432, 1517, 1552, 1584, 1630, 1671, 1705, 1878, 1920, 1950, 1982, 2029, 2070, 2127, 2173, 2242, 2360, 2399, 2443, 2486, 2536, 2576, 2636, 2874, 3050, 3188, 3259, 3318, 3460, 3514, 3551, 3572, 3603, 3690, 3770, 3885, 3947, 4004, 4058, 4117, 4180, 4280], 'Scholar).': [731, 790, 851, 1115, 1706, 2637, 2875, 3189, 3260, 3319, 3461, 3691, 3886, 3948, 4059], 'Moreover': [732, 2659], 'great': [735], 'sensitivity': [736], 'dynamic': [738, 2647], 'range': [739, 2648], 'afforded': [742], 'dyes,': [745], 'can': [748], 'give': [749], 'greater': [750], 'accuracy': [751], 'quantitation': [753, 799], 'than': [754, 3654], 'silver': [755], '(2Yan': [757], 'J.X.': [758], 'Devenish': [759], 'A.T.': [760, 2406], 'Wait': [761], 'R.': [762, 1301, 1369, 1678, 2207, 2334, 2604, 3416, 3430], 'Stone': [763], 'T.': [764, 1004, 1006, 1008, 1848, 1852, 2798, 3018, 3418], 'Lewis': [765], 'S.': [766, 768, 888, 956, 998, 1242, 1856, 2119, 2866, 3180, 3487, 3939], 'Fowler': [767], 'Fluorescence': [769], 'mass': [775, 979, 1061, 1325, 1424, 1661, 1912, 2389, 4109, 4170, 4272], 'spectrometry': [776, 1505], 'based': [777], 'proteomic': [778, 1306, 2009, 2215, 2370, 2422, 2426, 2561, 2614, 2895], 'Escherichia': [781], 'coli.Proteomics.': [782], '2002;': [783, 926, 1108, 1230, 1511, 1546, 1578, 1976, 2565, 3312, 3511, 3569, 3879], '2:': [784], '1682-1698Crossref': [785], '(187)': [788], 'It': [791, 3642], 'reported': [794, 3329, 4182], 'correlation': [797], 'between': [798, 1262, 1768, 2928, 3343], 'stable': [805, 834], 'isotope': [806, 835], 'labeling': [807], 'exceptionally': [809], 'good': [810], '(3Kolkman': [811], 'A.': [812, 1682, 2120, 2503, 2612, 2867, 3181, 3432, 3523, 3662, 3915, 3917, 3940, 4013], 'Dirksen': [813], 'E.H.': [814], 'Slijper': [815], 'M.': [816, 894, 996, 1680, 2077, 2326, 2507, 2602, 2824, 3010, 3024, 3414, 3482, 3497, 3759], 'Heck': [817], 'A.J.': [818], 'Double': [819], 'standards': [820], 'proteomics:': [823], 'direct': [824], 'comparative': [825, 2341], 'assessment': [826], 'labeling.Mol.': [836], 'Cell.': [837, 924, 1327, 2229, 2563, 3251, 3447], 'Proteomics.': [838, 925, 1328, 2230, 2564, 3448], '2005;': [839, 1030, 1065, 1383, 1426, 1665, 1872, 2064, 2121, 2480, 2530, 4111, 4174, 4274], '4:': [840, 982, 1066, 1666, 2631, 4175], '255-266Abstract': [841], 'Full': [842, 844, 929, 931, 1332, 1334, 2234, 2236, 2568, 2570, 3452, 3454, 3595, 3597, 4050, 4052], 'Text': [843, 845, 930, 932, 1333, 1335, 2235, 2237, 2569, 2571, 3453, 3455, 3596, 3598, 4051, 4053], 'PDF': [846, 933, 1336, 2238, 2572, 3456, 3599, 4054], '(86)': [849], 'addition,': [853, 3119], 'this': [854, 2964, 3699, 3727, 3775], 'method': [855, 3749], 'reduces': [856], 'number': [858, 1735], 'gels': [860], 'needed': [861], 'experiment.': [864], 'With': [865], 'advantages': [867], 'over': [868], 'traditional': [869], 'gives': [873], 'qualitative': [877, 1303], '(4Zhou': [881], 'Li': [883, 1290, 1350, 1360, 2190, 2392, 2811], 'H.': [884, 890, 994, 1002, 1287, 1347, 1522, 1559, 1850, 2142, 3491, 3495, 4017], 'DeCamp': [885], 'D.': [886, 1684, 2324, 2493, 2505], 'Chen': [887, 1635, 1996, 2837, 3518, 3856, 3982, 3986, 4144], 'Shu': [889], 'Gong': [891], 'Y.': [892, 909, 992, 1010, 1283, 1357, 1993, 2132, 2191, 2367, 3012, 3014, 3223], 'Flaig': [893], 'Gillespie': [895], 'J.W.': [896, 958, 1404, 1488, 4089, 4252], 'Hu': [897, 1598, 2137, 2815, 2833, 3224], 'N.': [898, 2495, 3016, 3583], 'Taylor': [899], 'P.R.': [900, 2081, 2606], 'Emmert-Buck': [901], 'M.R.': [902, 2195], 'Liotta': [903], 'L.A.': [904, 3851], 'Petricoin': [905], 'III,': [906], 'E.F.': [907], 'Zhao': [908, 2143, 2831], 'in-gel': [912], 'identification': [916, 1378, 1507, 1906], 'esophageal': [918], 'scans': [919], 'cell': [920, 1022, 1843, 1902, 1939, 2015], 'cancer-specific': [921], 'markers.Mol.': [923], '1:': [927, 2566], '117-124Abstract': [928], 'Scholar)': [936, 1433, 2030, 2243, 3051, 3604, 4118, 4181, 4281], 'thus': [939, 3703], 'studies': [944, 1445, 2735, 2782, 3955], 'several': [946, 1835, 3143], 'human': [947, 970, 1051, 1414, 1492, 1568, 1651, 1860, 1899, 1936, 2012, 2181, 2247, 2687, 3273, 3398, 3434, 3647, 3677, 3970, 3993, 4040, 4070, 4099, 4160, 4262], 'cancers,': [948, 1018], 'colon': [951, 971], '(5Friedman': [953], 'D.B.': [954], 'Hill': [955], 'Keller': [957], 'Merchant': [959], 'N.B.': [960], 'Levy': [961], 'S.E.': [962, 1883, 1929], 'Coffey': [963], 'R.J.': [964], 'Caprioli': [965], 'R.M.': [966], 'Proteome': [967, 1063, 1222, 1411, 1489, 1663, 1932, 1964, 3304, 4096, 4172, 4259], 'spectrometry.Proteomics.': [980, 1425, 4110, 4273], '793-811Crossref': [983], '(321)': [986], 'Scholar),': [988, 1037, 1165, 1278, 1390, 1585, 1631, 1672, 2174, 2577, 3573], 'prostate': [989, 1017, 1020], '(6Anazawa': [991], 'Nakagawa': [993], 'Furihara': [995], 'Ashida': [997], 'Tamura': [999], 'K.': [1000, 1846, 1854, 1891, 1923, 2136, 3022, 3026, 3556, 3660], 'Yoshioka': [1001], 'Shuin': [1003], 'Fujioka': [1005], 'Katagiri': [1007], 'Nakamura': [1009, 3025], 'PCOTH,': [1011], 'novel': [1013, 2057, 3236], 'overexpressed': [1015, 3060], 'promotes': [1019], 'growth': [1023], 'through': [1024], 'phosphorylation': [1025], 'oncoprotein': [1027], 'TAF-Iβ/SET.Cancer': [1028], 'Res.': [1029, 1064, 1228, 1273, 1664, 2020, 2063, 3310, 3510, 4173], '65:': [1031, 2065], '4578-4586Crossref': [1032], '(32)': [1035], 'pancreatic': [1039, 1052], '(7Yu': [1041], 'K.H.': [1042, 1528], 'Rustgi': [1043], 'A.K.': [1044], 'Blair': [1045], 'I.A.': [1046], 'Characterization': [1047, 3988], 'serum': [1054, 2104, 2284, 2344, 2425, 2467, 2521, 2618, 2654, 2664], 'using': [1055, 1312, 1697, 1842, 1863, 2757], 'tandem': [1060], 'spectrometry.J.': [1062, 1662, 4171], '1742-1751Crossref': [1067], '(135)': [1070], 'Scholar).Hepatocellular': [1072], 'cancers': [1081], 'worldwide': [1082, 2269], 'responsible': [1085, 3705], 'approximately': [1087], 'million': [1089], 'deaths': [1090], 'each': [1091], 'year': [1092], '(8Cha': [1093], 'C.': [1094, 1281, 1343, 1676, 2083, 2408, 2499, 2546, 3162, 3231, 4009], 'DeMatteo': [1095], 'R.P.': [1096], 'Blumgart': [1097], 'L.H.': [1098], 'Surgery': [1099], 'ablative': [1101], 'therapy': [1102, 1748], 'carcinoma.J.': [1105, 1968, 4045], 'Clin.': [1106, 2021], 'Gastroenterol.': [1107, 1157], '35:': [1109, 1547], 'S130-S137Crossref': [1110], '(63)': [1113, 3602], 'frequent': [1119, 1143, 2265], 'Asia': [1121], 'due': [1122, 1720], 'high': [1125, 2273, 2640], 'prevalence': [1126], 'HBV': [1129, 1176, 1789, 3115, 3157, 3344, 4220], 'HCV': [1131, 3113, 3346, 4222], 'infections.': [1132], 'China,': [1134], 'ranked': [1138], 'second': [1141, 3615], 'fatal': [1144], 'since': [1146], '1990s': [1148], '(9Tang': [1149], 'Z.Y.': [1150, 2001, 2211], 'carcinoma–cause,': [1152], 'treatment': [1153, 3563], 'metastasis.World': [1155], 'J.': [1156, 1460, 1576, 1700, 1997, 2134, 2138, 2497, 2788, 2804, 3160, 3878, 3996, 4019, 4023, 4025], '2001;': [1158, 1944, 2868], '7:': [1159], '445-454Crossref': [1160], '(391)': [1163], 'majority': [1168, 1808], 'HCCs': [1170], 'China': [1172, 1279, 1787], 'caused': [1174], 'infection.So': [1177], 'far,': [1178, 2933], 'research': [1182, 1436, 2580, 2726, 3281, 3389, 3478, 3734], 'focused': [1184], 'on': [1185, 1437, 1446, 1837, 2907], 'HBV/HCV-associated': [1186], 'Studies': [1188], 'done': [1191], 'laboratories': [1194, 1201, 1456], 'Asia,': [1196], 'Europe,': [1197], 'America.': [1199], 'Several': [1200], 'Korea': [1203, 1458], '(10Lim': [1204, 3286], 'S.O.': [1205, 3287], 'Park': [1206, 1210, 1255, 3288, 3292], 'S.J.': [1207, 1291, 1349, 1351, 1476, 2189, 3289, 3979], 'Kim': [1208, 1212, 1214, 1243, 1249, 1251, 1461, 1487, 1521, 1523, 1558, 3290, 3294, 3296, 3490], 'W.': [1209, 1239, 2816, 2830, 3291], 'S.G.': [1211, 3293], 'H.J.': [1213, 1250, 3295], 'Y.I.': [1215, 1252, 3297], 'Sohn': [1216, 3298], 'T.S.': [1217, 2095, 2412, 2592, 3299], 'Noh': [1218, 3300], 'J.H.': [1219, 1289, 3301], 'Jung': [1220, 1257, 3302], 'carcinoma.Biochem.': [1226, 3308], 'Biophys.': [1227, 3309], 'Commun.': [1229, 3311], '291:': [1231, 3313], '1031-1037Crossref': [1232, 3314], '(192)': [1235, 3317], 'Scholar,': [1237, 1341, 1518, 1553, 1879, 1921, 1951, 1983, 2071, 2128, 2361, 2400, 2444, 2487, 2537, 3515, 3552, 4005], '11Kim': [1238], 'Oe': [1240], 'Lim': [1241, 1403, 4088, 4251], 'J.S.': [1244, 1254, 1472, 3554], 'Ryu': [1245], 'Y.H.': [1246], 'Byeon': [1247], 'J.Y.': [1248, 3977], 'Heo': [1253], 'Y.M.': [1256, 3975], 'Comparison': [1259], 'virus-': [1265], 'carcinoma.Clin.': [1271], 'Cancer': [1272, 2019], '2003;': [1274, 2354, 2396, 2437, 3044, 3764, 3941], '9:': [1275], '5493-5500PubMed': [1276], '(12Li': [1280], 'Hong': [1282, 1356, 1479, 1586], 'Tan': [1284, 1344, 1399, 1958, 2192, 4084, 4247], 'Y.X.': [1285, 1345, 2193], 'Zhou': [1286, 1346], 'Ai': [1288], 'Zhang': [1292, 1358, 1992, 2145, 2799], 'Xia': [1294, 1362, 2212], 'Q.C.': [1295, 1363, 2213], 'Wu': [1296, 1364, 2204, 3222], 'J.R.': [1297, 1365, 2205, 2836], 'Wang': [1298, 1366, 2131, 2133, 2141, 2208], 'H.Y.': [1299, 1367, 1474, 1991, 2209], 'Zeng': [1300, 1368, 2206], 'Accurate': [1302], 'clinical': [1309, 1781, 1810, 2182, 2218, 2292, 2704], 'laser': [1313, 1503, 2384], 'capture': [1314], 'microdissection': [1315], 'coupled': [1316], 'isotope-coded': [1318], 'affinity': [1319], 'tag': [1320], 'liquid': [1323], 'chromatography': [1324], 'spectrometry.Mol.': [1326], '3:': [1330, 2232, 2355, 3045, 3450], '399-409Abstract': [1331], '(175)': [1339], '13Li': [1342], 'Ding': [1348], 'Ma': [1352], 'D.J.': [1353], 'Man': [1354], 'X.B.': [1355], 'Proteomic': [1370, 1533, 1562, 1604, 1690, 1857, 3027], 'carcinoma:': [1377], 'markers.Proteomics.': [1382], '5:': [1384, 1427, 1873, 4112, 4275], '1125-1139Crossref': [1385], '(108)': [1388], 'Singapore': [1392], '(14Liang': [1393, 4078, 4241], 'C.R.': [1394, 4079, 4242], 'Leow': [1395, 4080, 4243], 'C.K.': [1396, 4081, 4244], 'Neo': [1397, 1954, 4082, 4245], 'J.C.': [1398, 1638, 1955, 3499, 4083, 4147, 4246], 'G.S.': [1400, 1959, 4085, 4248], 'Lo': [1401, 1956, 4086, 4249], 'S.L.': [1402, 1957, 2203, 4087, 4250], 'Seow': [1405, 1924, 1960, 4090, 4253], 'T.K.': [1406, 1881, 1925, 1961, 4091, 4254], 'Lai': [1407, 4092, 4255], 'P.B.': [1408, 4093, 4256], 'Chung': [1409, 1892, 1930, 1962, 4094, 4257], 'M.C.': [1410, 1893, 1931, 1963, 4095, 4258], '2258-2271Crossref': [1428, 4113, 4276], '(91)': [1431, 4116, 4279], 'conducted': [1435], 'HBV-associated': [1438, 1762, 3100, 3129, 3274, 4198, 4292], 'Also': [1440], 'there': [1441, 1751, 3120], 'other': [1444, 2683], 'various': [1449], 'unclearly': [1451], 'described': [1452], 'viral': [1453], 'origins': [1454], '(15Kim': [1459], 'S.H.': [1462, 2328, 2826], 'Lee': [1463, 1477, 1485, 1639, 2413, 4139, 4148], 'S.U.': [1464], 'Ha': [1465, 1469, 1481], 'G.H.': [1466], 'Kang': [1467, 1475], 'D.G.': [1468, 3529], 'N.Y.': [1470], 'Ahn': [1471], 'Cho': [1473, 1525, 1556], 'Y.J.': [1478, 3983], 'S.C.': [1480, 3865, 3919, 4021], 'W.S.': [1482], 'Bae': [1483], 'J.M.': [1484, 1589, 2041, 3480, 3493, 3517, 3863, 3921, 4027], 'C.W.': [1486], 'matrix': [1501], 'assisted': [1502], 'desorption/ionization-mass': [1504], 'disease-related': [1509, 2661, 2692], 'proteins.Electrophoresis.': [1510], '23:': [1512], '4142-4156Crossref': [1513], '(116)': [1516, 1551], '16Park': [1519], 'K.S.': [1520, 1555], 'N.G.': [1524, 2812], 'S.Y.': [1526, 1557], 'Choi': [1527], 'Seong': [1529], 'J.K.': [1530], 'Paik': [1531, 1560], 'Y.K.': [1532, 1561, 1987, 2199], 'molecular': [1536, 3205, 3538], 'characterization': [1537], 'ferritin': [1540], 'light': [1541, 2906], 'chain': [1542], 'carcinoma.Hepatology.': [1545, 2479], '1459-1466Crossref': [1548], '17Park': [1554], 'variants': [1566], 'aldehyde': [1569], 'isozymes': [1571], 'correlate': [1572, 2107, 2626], 'carcinoma.Int.': [1575, 3995], 'Cancer.': [1577, 3997], '97:': [1579], '261-265Crossref': [1580], '(82)': [1583], 'Kong': [1587], '(18Luk': [1588], 'Lam': [1590, 1594, 2038], 'C.T.': [1591, 2039, 2043], 'Siu': [1592], 'A.F.': [1593], 'B.Y.': [1595], 'Ng': [1596], 'I.O.': [1597], 'M.Y.': [1599], 'Che': [1600], 'C.M.': [1601], 'Fan': [1602, 2048], 'S.T.': [1603, 2049], 'Chinese': [1610], 'cohort': [1611], 'reveals': [1612, 2623], 'heat-shock': [1613], '(Hsp27,': [1615], 'Hsp70,': [1616], 'GRP78)': [1617], 'up-regulation': [1618, 2150, 3352, 4184], 'associated': [1621], 'prognostic': [1622], 'values.Proteomics.': [1623], '2006;': [1624, 2167], '6:': [1625, 2168], '1049-1057Crossref': [1626], '(179)': [1629], 'Taiwan': [1632], '(19Lee': [1633, 4142], 'I.N.': [1634, 4143], 'C.H.': [1636, 4145], 'Sheu': [1637, 4146], 'H.S.': [1640, 2802, 4149], 'Huang': [1641, 2787, 2807, 2829, 3854, 4150], 'G.T.': [1642, 4151], 'Yu': [1643, 2002, 2044, 4152], 'C.Y.': [1644, 4153], 'Lu': [1645, 2819, 3864, 3918, 4020, 4154], 'F.J.': [1646, 3849, 3923, 4015, 4155], 'Chow': [1647, 4156], 'L.P.': [1648, 4157], 'Identification': [1649, 2050, 2512, 3232, 4158], 'carcinoma-related': [1653, 4162], 'biomarkers': [1654, 2350, 3037, 4163], '2062-2069Crossref': [1667, 4176], '(111)': [1670, 4179], 'Germany': [1674], '(20Melle': [1675], 'Kaufmann': [1677], 'Hommann': [1679], 'Bleul': [1681], 'Driesch': [1683], 'Ernst': [1685], 'von': [1687], 'Eggeling': [1688], 'F.': [1689, 2130, 2140, 2491, 2540, 2542, 2806], 'microdissected': [1693], 'ProteinChip': [1698], 'technology.Int.': [1699], 'Oncol.': [1701, 2022], '24:': [1703], '885-891PubMed': [1704], 'Some': [1707], 'could': [1711, 2709], 'coincident,': [1713], 'but': [1714, 2175, 3841], 'diversity': [1716], 'still': [1718], 'distinct': [1719, 2552], 'differences': [1723, 1767, 2252, 4225], 'sampling': [1725], 'techniques': [1727], 'used.': [1728], 'view': [1730], 'both': [1732, 2723], 'large': [1734], 'affected': [1738], 'together': [1739, 3349], 'limitations': [1742], 'diagnostic': [1744], 'effective': [1747], 'urgent': [1754], 'need': [1755], 'find': [1757], 'key': [1758], 'carcinogenesis-associated': [1759], 'molecules': [1760], 'diagnosis.To': [1764], 'accurately': [1765], 'quantitate': [1766], 'achieve': [1771], 'statistical': [1772], 'significance,': [1773], 'analyze': [1779], 'paired': [1780, 2747, 2947], 'background.': [1791], 'All': [1792], 'neoplasms': [1796], 'intermediate': [1798], 'differentiation': [1799], '(Edmondson': [1800], 'grade': [1801], 'II': [1802], 'III)': [1804], 'representative': [1805], 'cases.': [1812], 'identified,': [1818], 'interest': [1823], 'further': [1825, 2176, 2737], 'validated': [1826, 3194], 'staining.DISCUSSIONThere': [1832], 'reports': [1836], 'lines': [1844], '(22Fujii': [1845], 'Kondo': [1847], 'Yokoo': [1849], 'Yamada': [1851], 'Iwatsuki': [1853], 'Hirohashi': [1855], 'saturation': [1869], 'cysteine': [1870], 'dye.Proteomics.': [1871], '1411-1422Crossref': [1874], '(81)': [1877], '24Seow': [1880], 'Ong': [1882, 1928], 'Liang': [1884, 1926, 4075, 4238], 'R.C.': [1885, 1927, 1953], 'Ren': [1886], 'E.C.': [1887], 'Chan': [1888, 2405], 'Ou': [1890], 'map': [1896], 'line,': [1903, 1940], 'HCC-M,': [1904], 'separated': [1909], 'spectrometry.Electrophoresis.': [1913], '2000;': [1914, 4047], '21:': [1915], '1787-1813Crossref': [1916], '(142)': [1919], '25Ou': [1922], 'HCC-M:': [1941], 'update.Electrophoresis.': [1943], '22:': [1945, 3765], '2804-2811Crossref': [1946], '(31)': [1949], '26Liang': [1952], 'database': [1965], 'Chromatogr.': [1969], 'Anal.': [1971], 'Technol.': [1972], 'Biomed.': [1973], 'Life': [1974], 'Sci.': [1975, 2117, 2864, 3178, 3937], '771:': [1977], '303-328Crossref': [1978], '(49)': [1981], '27Cui': [1984], 'J.F.': [1985], 'Liu': [1986, 2139, 2198, 2805], 'Pan': [1988], 'B.S.': [1989, 2091], 'Song': [1990], 'Sun': [1994], 'R.X.': [1995], 'Feng': [1998], 'J.T.': [1999], 'Tang': [2000, 2210], 'Y.L.': [2003], 'Shen': [2004, 2817], 'H.L.': [2005], 'Yang': [2006, 2147, 4016], 'P.Y.': [2007], 'Differential': [2008], 'line': [2016], 'metastasis-associated': [2017], 'proteins.J.': [2018], '130:': [2024], '615-622Crossref': [2025], '(43)': [2028], 'animal': [2032], 'models': [2033], '(28Yang': [2034], 'Z.F.': [2035], 'Ho': [2036, 2417], 'D.W.': [2037], 'Luk': [2040], 'Lum': [2042], 'W.C.': [2045], 'Poon': [2046], 'R.T.': [2047], 'brain-derived': [2052], 'neurotrophic': [2053], 'factor': [2054, 3155], 'functional': [2058], 'carcinoma.Cancer': [2062], '219-225Crossref': [2066], '(216)': [2069], '29Block': [2072], 'T.M.': [2073, 2336, 2458, 2610], 'Comunale': [2074], 'M.A.': [2075, 2590, 2594, 3861, 3911, 4007], 'Lowman': [2076, 2593], 'Steel': [2078, 2449, 2607], 'L.F.': [2079, 2322, 2450, 2608], 'Romano': [2080, 2605], 'Fimmel': [2082], 'Tennant': [2084], 'B.C.': [2085], 'London': [2086, 2331, 2597], 'W.T.': [2087, 2332, 2598], 'Evans': [2088, 2329, 2595], 'A.A.': [2089, 2330, 2596], 'Blumberg': [2090], 'Dwek': [2092, 2333], 'R.A.': [2093], 'Mattu': [2094, 2591], 'Mehta': [2096, 2611], 'A.S.': [2097], 'Use': [2098], 'targeted': [2100], 'glycoproteomics': [2101], 'glycoproteins': [2105], 'woodchucks': [2112], 'humans.Proc.': [2114], 'Natl.': [2115, 2862, 3176, 3935], 'Acad.': [2116, 2863, 3177, 3936], 'U.': [2118, 2865, 3179, 3938], '102:': [2122], '779-784Crossref': [2123], '(325)': [2126], '30Cui': [2129], 'Wei': [2135], 'X.': [2144, 2146, 2148, 2800], 'proteasome': [2152], 'subunits': [2153], 'lysosomal': [2155], 'proteases': [2156], 'carcinomas': [2159, 2378], 'HBx': [2162], 'knockin': [2164], 'transgenic': [2165], 'mice.Proteomics.': [2166], '498-504Crossref': [2169], '(71)': [2172], 'validation': [2177, 2738], 'seemed': [2184], 'indicated': [2187, 3736], '(31Ding': [2188], 'Jiang': [2194], 'Tian': [2196], 'B.': [2197], 'Shao': [2200], 'X.X.': [2201], 'Ye': [2202], 'From': [2214], 'significance:': [2219], 'cytokeratin': [2222], '19': [2223], 'correlates': [2224], 'metastasis.Mol.': [2228], '73-81Abstract': [2233], '(174)': [2241], 'carcinogenesis': [2245, 2724, 2844, 3757], 'beings': [2248], 'vitro': [2255], 'rodent': [2257], 'neoplasm.': [2258], 'types': [2268], 'very': [2272, 2281], 'morbidity': [2274], 'mortality,': [2276], 'early': [2278], 'diagnosis': [2279, 3542], 'important.': [2282], 'Human': [2283], 'type': [2287], 'feasible': [2289], 'sample': [2290], 'detection.': [2293], 'Much': [2294], 'attention': [2295], 'paid': [2298], 'comparisons': [2300], 'sera': [2302, 2373], 'populations': [2304], 'sequential': [2306], 'progression': [2307, 2472], 'stages': [2314], 'disease': [2318, 2628, 3715], '(32Steel': [2321], 'Shumpert': [2323], 'Trotter': [2325], 'Seeholzer': [2327], 'Block': [2335, 2457, 2609], 'strategy': [2338], 'proteomes': [2345], 'discovery': [2348], 'carcinoma.Proteomics.': [2353, 3043], '601-609Crossref': [2356], '(158)': [2359], '33Wang': [2362], 'Z.': [2363, 2838, 3225], 'Ruan': [2364], 'Y.B.': [2365], 'Guan': [2366], 'Analysis': [2368], 'components': [2371], 'matrix-assisted': [2383], 'desorption/ionization': [2385], 'time': [2386], 'flying': [2388], 'spectrometry.Zhonghua': [2390], 'Bing': [2391], 'Xue': [2393], 'Za': [2394], 'Zhi.': [2395], '32:': [2397], '333-336PubMed': [2398], '34Poon': [2401], 'T.C.': [2402], 'Yip': [2403, 2407, 2409], 'T.T.': [2404], 'V.': [2410, 2489], 'Mok': [2411], 'C.C.': [2414], 'Leung': [2415], 'T.W.': [2416], 'S.K.': [2418], 'Johnson': [2419, 2453], 'P.J.': [2420], 'Comprehensive': [2421], 'identifies': [2424], 'signatures': [2427], 'detection': [2429, 2469, 3561], 'subtypes.Clin.': [2435], 'Chem.': [2436], '49:': [2438], '752-760Crossref': [2439], '(233)': [2442], '35Schwegler': [2445], 'E.E.': [2446], 'Cazares': [2447], 'Adam': [2451], 'B.L.': [2452], 'D.A.': [2454], 'Semmes': [2455, 2599], 'O.J.': [2456, 2600], 'Marrero': [2459], 'J.A.': [2460, 3658], 'Drake': [2461, 2603], 'R.R.': [2462], 'SELDI-TOF': [2463], 'MS': [2464], '41:': [2481, 2531], '634-642Crossref': [2482], '(141)': [2485, 2575], '36Paradis': [2488], 'Degos': [2490], 'Dargere': [2492], 'Pham': [2494], 'Belghiti': [2496], 'Degott': [2498], 'Janeau': [2500], 'J.L.': [2501], 'Bezeaud': [2502], 'Delforge': [2504], 'Cubizolles': [2506], 'Laurendeau': [2508], 'I.': [2509, 3020], 'Bedossa': [2510], 'P.': [2511, 3221], 'new': [2515, 2579], 'marker': [2516, 3506, 3539, 3590, 3639], 'diseases.Hepatology.': [2529], '40-47Crossref': [2532], '(218)': [2535], '37Le': [2538], 'Naour': [2539], 'Brichory': [2541], 'Misek': [2543, 3524], 'D.E.': [2544, 3525], 'Brechot': [2545], 'Hanash': [2547, 3526], 'S.M.': [2548, 3527], 'Beretta': [2549, 3581, 3584], 'repertoire': [2553], 'autoantibodies': [2555], 'analysis.Mol.': [2562], '197-203Abstract': [2567], 'aspect': [2581], 'glycosylation': [2584], 'also': [2586, 2776, 3191, 3277], '(38Comunale': [2589], 'Ward': [2601], 'Comparative': [2613], 'de-N-glycosylated': [2617], 'carriers': [2622], 'polypeptides': [2624], 'status.Proteomics.': [2629], '826-838Crossref': [2632], '(50)': [2635], 'abundance': [2641, 4030], 'wide': [2645], 'remain': [2649], 'technical': [2651], 'challenges': [2652], 'plasma': [2656, 2666, 2673, 3435], 'analysis.': [2658], 'diluted': [2670], '(∼5': [2671], 'liters': [2672], 'adult)': [2676], 'intermixed': [2678], 'unrelated': [2680], 'organs': [2684], 'body.': [2688], 'contrast,': [2690, 3395], 'those': [2691, 2857], 'highest': [2696], 'concentrations': [2697], 'tissue.': [2699], 'Those': [2700], 'will': [2702], 'application': [2705], 'if': [2707], 'they': [2708, 4192], 'released': [2711], 'into': [2712, 2842], 'blood,': [2714], 'material': [2719], 'adapts': [2721], 'biomarker': [2728], 'discovery.However,': [2729], 'previous': [2733, 3475], 'lacked': [2736], 'larger': [2740], 'populations.': [2741], 'We': [2742, 3190], 'analyzed': [2743], 'technique.': [2761], 'Among': [2762], '73': [2768], 'identified.': [2772], 'This': [2773, 3261, 3336, 3462], 'result': [2774, 3950, 4231], 'consistent': [2777, 3473, 3730, 3952], '(39Xu': [2785], 'X.R.': [2786], 'Xu': [2789, 2825], 'Z.G.': [2790, 2840], 'Qian': [2791], 'B.Z.': [2792], 'Zhu': [2793], 'Z.D.': [2794], 'Yan': [2795], 'Q.': [2796], 'Cai': [2797], 'Xiao': [2801], 'Qu': [2803], 'Q.H.': [2808], 'Cheng': [2809], 'Z.H.': [2810], 'Du': [2813], 'J.J.': [2814], 'K.T.': [2818], 'Fu': [2821], 'Zhong': [2823], 'Gu': [2827, 2835], 'W.Y.': [2828, 3985], 'X.T.': [2832], 'G.X.': [2834], 'Han': [2839], 'Insight': [2841], 'at': [2845], 'transcriptome': [2846], 'level': [2847], 'comparing': [2849], 'profiles': [2852], 'corresponding': [2859], 'noncancerous': [2860], 'liver.Proc.': [2861], '98:': [2869], '15089-15094Crossref': [2870], '(323)': [2873], 'conjunction': [2877], 'results,': [2881, 3627], 'which': [2882, 2900, 3199, 4283], 'recognized': [2885], 'consistency,': [2886], 'our': [2887, 3213, 3388, 3626], 'data': [2888, 4062], 'yielded': [2890], 'information': [2892], 'about': [2893, 2925], 'turn': [2902], 'help': [2904], 'shed': [2905], 'Furthermore': [2914], 'proteins,': [2917, 3088, 3635], 'HOP': [2918], 'hnRNP': [2920], 'C1/C2,': [2921], 'no': [2923], 'report': [2924], 'relationship': [2927], 'them': [2929], 'so': [2932], 'markers': [2939], 'tissues.Members': [2949], 'Heat': [2951], 'Shock': [2952], 'Protein': [2953], 'Families': [2957], 'Were': [2958, 3375], 'Both': [2959], 'Up-regulated': [2960], 'Tissues—In': [2963], 'study,': [2965, 3083, 3776], 'five': [2968], 'including': [2978, 3065, 3636], 'three': [2979, 4213, 4289], 'members': [2980, 2995, 3035, 3054, 3126, 3265, 3322, 3359], 'HSP': [2983, 2988, 2991, 2998, 3057, 3078, 3092, 3123, 3134, 3216, 3267, 3325, 3361], 'family': [2985, 3000, 3034, 3059, 3125, 3327], '(GRP': [2986], '78,': [2987, 3067], '70.1,': [2989, 3093], '70RY)': [2992], '(HSP': [3001], 'GRP': [3004, 3066, 3075, 3089], '94).': [3005], 'Takashima': [3006], 'et': [3007, 4076, 4140, 4239], 'al.': [3008, 4077, 4141, 4240], '(40Takashima': [3009], 'Kuramitsu': [3011], 'Yokoyama': [3013], 'Iizuka': [3015], 'Toda': [3017], 'Sakaida': [3019], 'Okita': [3021], 'Oka': [3023], 'virus-related': [3041], '2487-2493Crossref': [3046], '(124)': [3049], 'found': [3052, 3095, 3278, 4119], 'four': [3053, 3087, 3444, 3777], 'HCV-associated': [3062, 3334], 'cognate': [3070], '71-kDa': [3071], '(HSC': [3073], '70),': [3074], '75,': [3076], '70.1.': [3079], 'present': [3082], '78': [3090], 'not': [3108], 'specific': [3110], 'either': [3112], 'infection-associated': [3116], 'One': [3131], 'them,': [3133], '90,': [3135], 'known': [3137], 'essential': [3140, 3153, 3802], 'component': [3141], 'signal': [3144], 'transduction': [3145], 'pathways': [3146], 'host': [3154], 'replication': [3158], '(41Hu': [3159], 'Seeger': [3161], 'Hsp90': [3163], 'required': [3165], 'activity': [3168], 'reverse': [3174], 'transcriptase.Proc.': [3175], '1996;': [3182], '93:': [3183], '1060-1064Crossref': [3184], '(291)': [3187], 'mediates': [3200], 'association': [3202], 'chaperones': [3206], 'HSC': [3207], '(ratiotumor/nontumor': [3209], '=': [3210], '1.6': [3211], 'results)': [3214], '(42Ballinger': [3218], 'C.A.': [3219], 'Connell': [3220], 'Thompson': [3226], 'L.J.': [3227], 'Yin': [3228], 'L.Y.': [3229], 'Patterson': [3230], 'CHIP,': [3234], 'tetratricopeptide': [3237], 'repeat-containing': [3238], 'interacts': [3241], 'negatively': [3247], 'regulates': [3248], 'chaperone': [3249], 'functions.Mol.': [3250], 'Biol.': [3252], '1999;': [3253, 3684], '19:': [3254], '4535-4545Crossref': [3255], '(741)': [3258], 'simultaneous': [3262], 'Korean': [3284], 'group': [3285], 'only': [3321, 3409], 'reflect': [3338], 'pathogenesis': [3342], 'infection,': [3347], 'HBV-related': [3370], 'carcinogenesis.Mitochondrial': [3371], 'Peroxisomal': [3373], 'Proteins': [3374], 'Down-regulated—A': [3376], 'finding': [3377], 'note': [3379], '27%': [3382], 'located': [3391], 'mitochondria.': [3393], 'proteome,': [3399], 'proportion': [3401, 3617], 'assigned': [3404], 'mitochondria': [3407, 3465, 3741], '4%': [3410], '(43Anderson': [3411], 'N.L.': [3412], 'Polanski': [3413], 'Pieper': [3415], 'Gatlin': [3417], 'Tirumalai': [3419], 'R.S.': [3420], 'Conrads': [3421], 'T.P.': [3422], 'Veenstra': [3423], 'T.D.': [3424], 'Adkins': [3425], 'J.N.': [3426], 'Pounds': [3427], 'J.G.': [3428], 'Fagan': [3429], 'Lobley': [3431], 'proteome:': [3436], 'nonredundant': [3438], 'list': [3439], 'developed': [3440], 'combination': [3442], 'separate': [3445], 'sources.Mol.': [3446], '311-326Abstract': [3451], '(749)': [3459], '(44Cuezva': [3479], 'Krajewska': [3481], 'de': [3483], 'Heredia': [3484], 'M.L.': [3485, 3847], 'Krajewski': [3486], 'Santamaria': [3488], 'Zapata': [3492], 'Marusawa': [3494], 'Chamorro': [3496], 'Reed': [3498], 'bioenergetic': [3501, 3531], 'signature': [3502, 3532], 'cancer:': [3504], 'progression.Cancer': [3509], '62:': [3512], '6674-6681PubMed': [3513], '45Cuezva': [3516], 'Alonso': [3520], 'A.M.': [3521], 'Isidoro': [3522], 'Beer': [3528], 'lung': [3534], 'adenocarcinomas': [3535], 'prognosis.Carcinogenesis.': [3544], '25:': [3546], '1157-1163Crossref': [3547], '(129)': [3550], '46Modica-Napolitano': [3553], 'Singh': [3555], 'Mitochondria': [3557], 'targets': [3559, 3932], 'cancer.Expert': [3565], 'Rev.': [3566, 3763], 'Mol.': [3567], 'Med.': [3568], '2002:': [3570], '1-19Crossref': [3571], 'conclusion': [3577], 'Chignard': [3579], '(47Chignard': [3582], 'discovery.Gastroenterology.': [3591], '127:': [3593], 'S120-S125Abstract': [3594], 'means': [3607], '2DE/MS': [3609], 'made': [3612], 'up': [3613], 'largest': [3616], '(19%)': [3618], 'dysregulated': [3621], 'HCC.In': [3625], '8%': [3628], 'catalase.': [3641], 'demonstrated': [3645, 4284], 'cells': [3650], 'contain': [3651], 'fewer': [3652], 'peroxisomes': [3653], 'extrafocal': [3655], 'hepatocytes': [3656], '(48Litwin': [3657], 'Beier': [3659], 'Volkl': [3661], 'Hofmann': [3663], 'W.J.': [3664], 'Fahimi': [3665], 'H.D.': [3666], 'Immunocytochemical': [3667], 'investigation': [3668], 'catalase': [3670], 'lipid': [3673], 'beta-oxidation': [3674], 'tumors': [3679, 3871], 'cirrhosis.Virchows': [3682], 'Arch.': [3683], '435:': [3685], '486-495Crossref': [3686], '(40)': [3689], 'Neoplastic': [3692], 'transformation': [3693], 'affect': [3695], 'biogenesis': [3697], 'some': [3707], 'derangements': [3711], 'observed': [3712], 'processes': [3716], 'detailed': [3738], 'subcellular': [3739], '(e.g.': [3740], 'peroxisome)': [3743], 'demonstration': [3752], '(49Dreger': [3758], 'Subcellular': [3760], 'proteomics.Mass': [3761], 'Spectrom.': [3762], '27-56Crossref': [3766], '(134)': [3769], 'Scholar).Down-regulation': [3771], 'Methylation-related': [3773], 'Enzymes—In': [3774], 'liver,': [3787], 'tissues.': [3797, 4189], 'MAT': [3798, 4186], 'enzyme': [3801], 'formation': [3805], '(AdoMet)': [3808], 'cycle.': [3812], 'COMT': [3820], 'reflected': [3821], 'decrease': [3823], 'AdoMet': [3825, 3832, 3897], 'liver.': [3828], 'Chronic': [3829], 'spontaneous': [3835], 'development': [3836], 'steatohepatitis': [3838], 'remains': [3844], 'unknown': [3845], '(50Martinez-Chantar': [3846], 'Corrales': [3848, 3922, 4014], 'Martinez-Cruz': [3850], 'Garcia-Trevijano': [3852], 'E.R.': [3853], 'Z.Z.': [3855], 'Kanel': [3858], 'Avila': [3860, 3910], 'Mato': [3862, 3920, 4026], 'Spontaneous': [3866], 'oxidative': [3867, 3903], 'stress': [3868, 3904], 'mice': [3873, 3891], 'lacking': [3874], 'adenosyltransferase': [3876], '1A.FASEB': [3877], '16:': [3880], '1292-1294Crossref': [3881], '(234)': [3884], 'knock-out': [3890], 'showed': [3892], 'impairs': [3898], 'function': [3900], 'generates': [3902], '(51Santamaria': [3908], 'E.': [3909], 'Latasa': [3912], 'M.U.': [3913], 'Rubio': [3914], 'Martin-Duce': [3916, 4012], 'Functional': [3924], 'nonalcoholic': [3927], 'steatohepatitis:': [3928], 'S-adenosylmethionine.Proc.': [3934], '100:': [3942], '3065-3070Crossref': [3943], '(137)': [3946], 'Our': [3949, 4233], 'earlier': [3954], 'showing': [3956], 'mRNA': [3959, 4029], 'levels': [3960], 'GNMT': [3965, 4126], 'markedly': [3967], 'reduced': [3968], 'cirrhosis': [3971, 4042], '(52Chen': [3974], 'Shiu': [3976], 'Tzeng': [3978], 'Shih': [3980], 'L.S.': [3981], 'Lui': [3984], 'P.H.': [3987], 'glycine-N-methyltransferase-gene': [3990], '1998;': [3998], '75:': [3999], '787-793Crossref': [4000], '(78)': [4003], '53Avila': [4006], 'Berasain': [4008], 'Torres': [4010], 'Prieto': [4018], 'Caballeria': [4022], 'Rodes': [4024], 'Reduced': [4028], 'main': [4033], 'metabolism': [4038], 'Hepatol.': [4046], '33:': [4048], '907-914Abstract': [4049], '(285)': [4057], 'regarding': [4063], 'discrepant.': [4074], 'poorly': [4128], 'differentiated': [4129, 4136], 'BHMT': [4133], 'well': [4135], 'seven': [4195], 'pairs': [4196, 4202], 'eight': [4201], 'pathogenic': [4207], 'backgrounds': [4208], '(two': [4209], 'HBV-': [4210], 'HCV-infected,': [4212, 4216], 'HBV-infected,': [4214], 'without': [4219], 'infection).': [4223], 'Sample': [4224], 'reason': [4229], 'discrepancy.': [4232], 'strongly': [4235], 'supported': [4236], 'data,': [4282], 'similar': [4285], 'relati': [4298]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2159492800', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 19}], 'updated_date': '2024-12-24T13:28:32.189592', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
