Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2158892689', 'doi': 'https://doi.org/10.1038/onc.2009.343', 'title': 'Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells', 'display_name': 'Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells', 'publication_year': 2009, 'publication_date': '2009-11-02', 'ids': {'openalex': 'https://openalex.org/W2158892689', 'doi': 'https://doi.org/10.1038/onc.2009.343', 'mag': '2158892689', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19881538', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2809784'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/onc.2009.343', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1038/onc.2009.343', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064496142', 'display_name': 'Keying Zhu', 'orcid': 'https://orcid.org/0000-0001-7500-1532'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K Zhu', 'raw_affiliation_strings': ['Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020416143', 'display_name': 'K Dunner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K Dunner', 'raw_affiliation_strings': ['Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5059536506', 'display_name': 'David J. McConkey', 'orcid': 'https://orcid.org/0000-0003-1971-0638'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'D J McConkey', 'raw_affiliation_strings': ['Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4390, 'currency': 'EUR', 'value_usd': 5490, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 13.54, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 313, 'citation_normalized_percentile': {'value': 0.999965, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '29', 'issue': '3', 'first_page': '451', 'last_page': '462'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Unfolded Protein Response', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proteasome-inhibitors', 'display_name': 'Proteasome Inhibitors', 'score': 0.573786}, {'id': 'https://openalex.org/keywords/proteasome', 'display_name': 'Proteasome', 'score': 0.545234}, {'id': 'https://openalex.org/keywords/autophagy', 'display_name': 'Autophagy', 'score': 0.522092}, {'id': 'https://openalex.org/keywords/protein-degradation', 'display_name': 'Protein degradation', 'score': 0.5092219}], 'concepts': [{'id': 'https://openalex.org/C2781000418', 'wikidata': 'https://www.wikidata.org/wiki/Q18034312', 'display_name': 'ATG5', 'level': 4, 'score': 0.9281727}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.85967565}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7503032}, {'id': 'https://openalex.org/C27740335', 'wikidata': 'https://www.wikidata.org/wiki/Q14878333', 'display_name': 'Proteasome', 'level': 2, 'score': 0.68233854}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.64093244}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.5756954}, {'id': 'https://openalex.org/C2992195973', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Protein degradation', 'level': 2, 'score': 0.5092219}, {'id': 'https://openalex.org/C2778367456', 'wikidata': 'https://www.wikidata.org/wiki/Q7251235', 'display_name': 'Proteasome inhibitor', 'level': 3, 'score': 0.4525983}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.43432635}, {'id': 'https://openalex.org/C22615655', 'wikidata': 'https://www.wikidata.org/wiki/Q203221', 'display_name': 'Small interfering RNA', 'level': 4, 'score': 0.42684346}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.4234224}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.42188582}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.29134837}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.21529144}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1712724}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.16620186}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.10364413}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.05785474}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D010588', 'descriptor_name': 'Phagosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D061988', 'descriptor_name': 'Proteasome Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000071187', 'descriptor_name': 'Autophagy-Related Protein 5', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071193', 'descriptor_name': 'Autophagy-Related Protein 7', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001897', 'descriptor_name': 'Boronic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001897', 'descriptor_name': 'Boronic Acids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000069286', 'descriptor_name': 'Bortezomib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015151', 'descriptor_name': 'Immunoblotting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007783', 'descriptor_name': 'Lactones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007783', 'descriptor_name': 'Lactones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046529', 'descriptor_name': 'Microscopy, Electron, Transmission', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010588', 'descriptor_name': 'Phagosomes', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D010588', 'descriptor_name': 'Phagosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011758', 'descriptor_name': 'Pyrroles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011758', 'descriptor_name': 'Pyrroles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044764', 'descriptor_name': 'Ubiquitin-Activating Enzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044764', 'descriptor_name': 'Ubiquitin-Activating Enzymes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D044764', 'descriptor_name': 'Ubiquitin-Activating Enzymes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/onc.2009.343', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809784', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19881538', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/onc.2009.343', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.71, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1523693806', 'https://openalex.org/W1579227195', 'https://openalex.org/W1963521777', 'https://openalex.org/W1969342645', 'https://openalex.org/W1976531450', 'https://openalex.org/W1984426737', 'https://openalex.org/W1985275612', 'https://openalex.org/W1987583882', 'https://openalex.org/W1989016316', 'https://openalex.org/W1989602074', 'https://openalex.org/W1993643473', 'https://openalex.org/W1994823455', 'https://openalex.org/W1999150533', 'https://openalex.org/W2000187136', 'https://openalex.org/W2001467419', 'https://openalex.org/W2010140285', 'https://openalex.org/W2010184965', 'https://openalex.org/W2018636808', 'https://openalex.org/W2022317389', 'https://openalex.org/W2022812113', 'https://openalex.org/W2025714022', 'https://openalex.org/W2026827682', 'https://openalex.org/W2027821655', 'https://openalex.org/W2038012199', 'https://openalex.org/W2048030072', 'https://openalex.org/W2068213179', 'https://openalex.org/W2074911710', 'https://openalex.org/W2077247713', 'https://openalex.org/W2086853865', 'https://openalex.org/W2088239064', 'https://openalex.org/W2089198803', 'https://openalex.org/W2103596198', 'https://openalex.org/W2106255061', 'https://openalex.org/W2109034822', 'https://openalex.org/W2113915760', 'https://openalex.org/W2113971983', 'https://openalex.org/W2127916470', 'https://openalex.org/W2128537698', 'https://openalex.org/W2130104604', 'https://openalex.org/W2131612416', 'https://openalex.org/W2144428144', 'https://openalex.org/W2146887271', 'https://openalex.org/W2158971210', 'https://openalex.org/W2288573335', 'https://openalex.org/W24389446', 'https://openalex.org/W4254370508'], 'related_works': ['https://openalex.org/W4241988085', 'https://openalex.org/W3140464118', 'https://openalex.org/W3032840474', 'https://openalex.org/W3022694556', 'https://openalex.org/W2909658834', 'https://openalex.org/W2360552219', 'https://openalex.org/W2321752808', 'https://openalex.org/W2133565927', 'https://openalex.org/W2124704672', 'https://openalex.org/W2061628243'], 'abstract_inverted_index': {'The': [0], 'ubiquitin-proteasome': [1], 'and': [2, 28, 48, 64, 73, 81, 90, 138, 153, 182], 'lysosome-autophagy': [3], 'pathways': [4], 'are': [5, 32], 'the': [6, 54, 68, 100, 112, 139], 'two': [7], 'major': [8], 'intracellular': [9, 145], 'protein': [10, 114, 146, 180], 'degradation': [11, 162], 'systems': [12], 'that': [13, 45, 169], 'work': [14], 'cooperatively': [15], 'to': [16, 178], 'maintain': [17], 'homeostasis.': [18], 'Proteasome': [19], 'inhibitors': [20, 29], '(PIs)': [21], 'have': [22], 'clinical': [23], 'activity': [24], 'in': [25, 75, 94, 125], 'hematological': [26], 'tumors,': [27], 'of': [30, 53, 67, 88, 99, 111, 132, 136, 144, 149], 'autophagy': [31, 121, 137, 173], 'also': [33], 'being': [34], 'evaluated': [35], 'as': [36], 'potential': [37], 'antitumor': [38], 'therapies.': [39], 'In': [40], 'this': [41], 'study,': [42], 'we': [43], 'found': [44], 'chemical': [46], 'PIs': [47, 117], 'small': [49], 'interfering': [50], 'RNA-mediated': [51], 'knockdown': [52], "proteasome's": [55], 'enzymatic': [56], 'subunits': [57], 'promoted': [58], 'autophagosome': [59], 'formation,': [60], 'stimulated': [61], 'autophagic': [62], 'flux,': [63], 'upregulated': [65], 'expression': [66], 'autophagy-specific': [69], 'genes': [70], '(ATGs)': [71], '(ATG5': [72], 'ATG7)': [74], 'some': [76], 'human': [77], 'prostate': [78], 'cancer': [79, 156], 'cells': [80, 95], 'immortalized': [82], 'mouse': [83], 'embryonic': [84], 'fibroblasts': [85], '(MEFs).': [86], 'Upregulation': [87], 'ATG5': [89, 124], 'ATG7': [91], 'only': [92], 'occurred': [93], 'displaying': [96], 'PI-induced': [97], 'phosphorylation': [98], 'eukaryotic': [101], 'translation': [102], 'initiation': [103], 'factor': [104], '2': [105], 'alpha': [106], '(eIF2alpha),': [107], 'an': [108, 142], 'important': [109], 'component': [110], 'unfolded': [113], 'responses.': [115], 'Furthermore,': [116], 'did': [118], 'not': [119], 'induce': [120], 'or': [122], 'upregulate': [123], 'MEFs': [126], 'expressing': [127], 'a': [128, 175], 'phosphorylation-deficient': [129], 'mutant': [130], 'form': [131], 'eIF2alpha.': [133], 'Combined': [134], 'inhibition': [135, 171], 'proteasome': [140, 170], 'induced': [141], 'accumulation': [143], 'aggregates': [147, 181], 'reminiscent': [148], 'neuronal': [150], 'inclusion': [151], 'bodies': [152], 'caused': [154], 'more': [155], 'cell': [157], 'death': [158], 'than': [159], 'blocking': [160], 'either': [161], 'pathway': [163], 'alone.': [164], 'Overall,': [165], 'our': [166], 'data': [167], 'show': [168], 'activates': [172], 'through': [174], 'phospho-eIF2alpha-dependent': [176], 'mechanism': [177], 'eliminate': [179], 'alleviate': [183], 'proteotoxic': [184], 'stress.': [185]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2158892689', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 21}, {'year': 2018, 'cited_by_count': 21}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 24}, {'year': 2015, 'cited_by_count': 30}, {'year': 2014, 'cited_by_count': 27}, {'year': 2013, 'cited_by_count': 31}, {'year': 2012, 'cited_by_count': 31}], 'updated_date': '2024-09-14T00:10:18.177222', 'created_date': '2016-06-24'}