Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2158334499', 'doi': 'https://doi.org/10.1002/1097-4636(200011)52:2<374::aid-jbm18>3.0.co;2-z', 'title': 'Glutardialdehyde induced fluorescence technique (GIFT): A new method for the imaging of platelet adhesion on biomaterials', 'display_name': 'Glutardialdehyde induced fluorescence technique (GIFT): A new method for the imaging of platelet adhesion on biomaterials', 'publication_year': 2000, 'publication_date': '2000-01-01', 'ids': {'openalex': 'https://openalex.org/W2158334499', 'doi': 'https://doi.org/10.1002/1097-4636(200011)52:2<374::aid-jbm18>3.0.co;2-z', 'mag': '2158334499', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10951378'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/1097-4636(200011)52:2<374::aid-jbm18>3.0.co;2-z', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S34814058', 'display_name': 'Journal of Biomedical Materials Research', 'issn_l': '0021-9304', 'issn': ['0021-9304', '1097-4636'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5044141356', 'display_name': 'Rolf Dario Frank', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I887968799', 'display_name': 'RWTH Aachen University', 'ror': 'https://ror.org/04xfq0f34', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I887968799']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Rolf Dario Frank', 'raw_affiliation_strings': ['Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Pauwelsstr. 30, 52057 Aachen, Germany', 'IZKF "Biomat." University Hospital RWTH Aachen, Pauwelsstr. 30, 52057 Aachen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Pauwelsstr. 30, 52057 Aachen, Germany', 'institution_ids': ['https://openalex.org/I887968799']}, {'raw_affiliation_string': 'IZKF "Biomat." University Hospital RWTH Aachen, Pauwelsstr. 30, 52057 Aachen, Germany', 'institution_ids': ['https://openalex.org/I887968799']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006472903', 'display_name': 'Heike Dresbach', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I887968799', 'display_name': 'RWTH Aachen University', 'ror': 'https://ror.org/04xfq0f34', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I887968799']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Heike Dresbach', 'raw_affiliation_strings': ['IZKF "Biomat." University Hospital RWTH Aachen, Pauwelsstr. 30, 52057 Aachen, Germany'], 'affiliations': [{'raw_affiliation_string': 'IZKF "Biomat." University Hospital RWTH Aachen, Pauwelsstr. 30, 52057 Aachen, Germany', 'institution_ids': ['https://openalex.org/I887968799']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031717706', 'display_name': 'H. Thelen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I887968799', 'display_name': 'RWTH Aachen University', 'ror': 'https://ror.org/04xfq0f34', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I887968799']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Herbert Thelen', 'raw_affiliation_strings': ['IZKF "Biomat." University Hospital RWTH Aachen, Pauwelsstr. 30, 52057 Aachen, Germany'], 'affiliations': [{'raw_affiliation_string': 'IZKF "Biomat." University Hospital RWTH Aachen, Pauwelsstr. 30, 52057 Aachen, Germany', 'institution_ids': ['https://openalex.org/I887968799']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5054285726', 'display_name': 'Heinz-G�nter Sieberth', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I887968799', 'display_name': 'RWTH Aachen University', 'ror': 'https://ror.org/04xfq0f34', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I887968799']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Heinz-G�nter Sieberth', 'raw_affiliation_strings': ['Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Pauwelsstr. 30, 52057 Aachen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Pauwelsstr. 30, 52057 Aachen, Germany', 'institution_ids': ['https://openalex.org/I887968799']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5044141356'], 'corresponding_institution_ids': ['https://openalex.org/I887968799'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.323, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 58, 'citation_normalized_percentile': {'value': 0.872542, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '52', 'issue': '2', 'first_page': '374', 'last_page': '381'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Thrombosis Mechanisms', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Thrombosis Mechanisms', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10859', 'display_name': 'Mussel-Inspired Surface Chemistry for Multifunctional Coatings', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/2508', 'display_name': 'Surfaces, Coatings and Films'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11721', 'display_name': 'Blood Rheology and Coagulation Mechanisms', 'score': 0.9711, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thrombogenicity', 'display_name': 'Thrombogenicity', 'score': 0.9416376}, {'id': 'https://openalex.org/keywords/surface-chemistry', 'display_name': 'Surface Chemistry', 'score': 0.499015}], 'concepts': [{'id': 'https://openalex.org/C2776649359', 'wikidata': 'https://www.wikidata.org/wiki/Q7798338', 'display_name': 'Thrombogenicity', 'level': 3, 'score': 0.9416376}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.7467501}, {'id': 'https://openalex.org/C136229726', 'wikidata': 'https://www.wikidata.org/wiki/Q327092', 'display_name': 'Biomedical engineering', 'level': 1, 'score': 0.7236231}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.71608603}, {'id': 'https://openalex.org/C84416704', 'wikidata': 'https://www.wikidata.org/wiki/Q188666', 'display_name': 'Adhesion', 'level': 2, 'score': 0.6744931}, {'id': 'https://openalex.org/C169274487', 'wikidata': 'https://www.wikidata.org/wiki/Q840211', 'display_name': 'Fluorescence microscope', 'level': 3, 'score': 0.5400335}, {'id': 'https://openalex.org/C91881484', 'wikidata': 'https://www.wikidata.org/wiki/Q191807', 'display_name': 'Fluorescence', 'level': 2, 'score': 0.5252756}, {'id': 'https://openalex.org/C3018697912', 'wikidata': 'https://www.wikidata.org/wiki/Q179217', 'display_name': 'Platelet activation', 'level': 3, 'score': 0.4681668}, {'id': 'https://openalex.org/C26771246', 'wikidata': 'https://www.wikidata.org/wiki/Q321095', 'display_name': 'Scanning electron microscope', 'level': 2, 'score': 0.4417431}, {'id': 'https://openalex.org/C42360764', 'wikidata': 'https://www.wikidata.org/wiki/Q83588', 'display_name': 'Chemical engineering', 'level': 1, 'score': 0.36658797}, {'id': 'https://openalex.org/C171250308', 'wikidata': 'https://www.wikidata.org/wiki/Q11468', 'display_name': 'Nanotechnology', 'level': 1, 'score': 0.33615717}, {'id': 'https://openalex.org/C159985019', 'wikidata': 'https://www.wikidata.org/wiki/Q181790', 'display_name': 'Composite material', 'level': 1, 'score': 0.2155213}, {'id': 'https://openalex.org/C120665830', 'wikidata': 'https://www.wikidata.org/wiki/Q14620', 'display_name': 'Optics', 'level': 1, 'score': 0.091682166}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.07766482}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.077242285}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001672', 'descriptor_name': 'Biocompatible Materials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005976', 'descriptor_name': 'Glutaral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010973', 'descriptor_name': 'Platelet Adhesiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005456', 'descriptor_name': 'Fluorescent Dyes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008722', 'descriptor_name': 'Methods', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/1097-4636(200011)52:2<374::aid-jbm18>3.0.co;2-z', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S34814058', 'display_name': 'Journal of Biomedical Materials Research', 'issn_l': '0021-9304', 'issn': ['0021-9304', '1097-4636'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10951378', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.59, 'id': 'https://metadata.un.org/sdg/10', 'display_name': 'Reduced inequalities'}, {'score': 0.41, 'id': 'https://metadata.un.org/sdg/16', 'display_name': 'Peace, justice, and strong institutions'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1964353364', 'https://openalex.org/W1964457773', 'https://openalex.org/W1973899827', 'https://openalex.org/W1981689350', 'https://openalex.org/W1982188157', 'https://openalex.org/W1994941050', 'https://openalex.org/W1996219864', 'https://openalex.org/W2001199619', 'https://openalex.org/W2004325677', 'https://openalex.org/W2008380942', 'https://openalex.org/W2026270726', 'https://openalex.org/W2037777250', 'https://openalex.org/W2043173024', 'https://openalex.org/W2048220527', 'https://openalex.org/W2056963672', 'https://openalex.org/W2061492820', 'https://openalex.org/W2070873807', 'https://openalex.org/W2080004636', 'https://openalex.org/W2088727446', 'https://openalex.org/W2092707431', 'https://openalex.org/W2102374658', 'https://openalex.org/W2115251938', 'https://openalex.org/W2135131000', 'https://openalex.org/W2150979821', 'https://openalex.org/W2152834983', 'https://openalex.org/W2260350694', 'https://openalex.org/W3021727476', 'https://openalex.org/W644267517'], 'related_works': ['https://openalex.org/W4302324012', 'https://openalex.org/W4248554551', 'https://openalex.org/W4212980501', 'https://openalex.org/W3086625087', 'https://openalex.org/W2904944300', 'https://openalex.org/W2127161817', 'https://openalex.org/W2062077711', 'https://openalex.org/W2057882783', 'https://openalex.org/W1988467799', 'https://openalex.org/W1967892882'], 'abstract_inverted_index': {'One': [0], 'of': [1, 5, 16, 24, 37, 47, 59, 66, 82, 98, 123, 144, 159, 168, 199, 232, 262, 269, 291, 298, 300], 'the': [2, 11, 33, 64, 79, 99, 121, 164, 196, 212, 270, 288, 296], 'major': [3], 'limitations': [4], 'biomaterials': [6, 301], 'used': [7], 'in': [8, 250], 'medicine': [9], 'is': [10, 131, 280], 'adhesion': [12, 84, 225, 264], 'and': [13, 35, 53, 70, 103, 110, 130, 135, 149, 178, 185, 193, 226, 247, 253, 284], 'subsequent': [14], 'activation': [15], 'platelets': [17, 125], 'upon': [18], 'contact': [19, 86], 'with': [20, 87, 139, 191, 195, 222, 236, 274], 'blood.': [21], 'The': [22, 114, 215, 229], 'development': [23], 'new': [25], 'or': [26, 56, 107, 241], 'modified': [27], 'materials': [28, 167], 'necessitates': [29], 'adequate': [30], 'methods': [31], 'for': [32, 78, 133, 255, 287, 295], 'detection': [34], 'quantification': [36, 58], 'platelet/material': [38, 292], 'interactions.': [39], 'These': [40], 'interactions': [41, 293], 'are': [42], 'commonly': [43], 'investigated': [44, 182, 213], 'by': [45, 57, 127, 183], 'means': [46], 'scanning': [48], 'electron': [49], 'microscopy': [50, 129], '(SEM),': [51], 'radioisotope': [52], 'immunological': [54, 108], 'techniques,': [55], 'released': [60], 'platelet': [61, 83, 100, 151, 224, 263, 271], 'contents.': [62], 'Given': [63], 'lack': [65], 'a': [67, 75, 281], 'simple,': [68], 'rapid,': [69, 283], 'inexpensive': [71], 'assay,': [72], 'we': [73], 'developed': [74], 'novel': [76], 'method': [77, 286], 'accurate': [80], 'assessment': [81, 261], 'after': [85], 'foreign': [88], 'surfaces,': [89], 'which': [90, 104], 'enables': [91], 'quantitative': [92, 260, 289], 'measurements': [93], 'as': [94, 96, 157, 234, 265, 267], 'well': [95, 266], 'imaging': [97, 268], 'shape': [101, 227, 272], 'change,': [102], 'omits': [105], 'conventional': [106], 'staining': [109], 'time-consuming': [111, 244], 'preparative': [112], 'steps.': [113], 'glutardialdehyde': [115], 'induced': [116], 'fluorescence': [117, 128, 248], 'technique': [118], '(GIFT)': [119], 'uses': [120], 'epifluorescence': [122], 'glutardialdehyde-fixed': [124], 'detected': [126], 'suitable': [132], 'opaque': [134], 'transparent': [136], 'materials.': [137, 214], 'Combined': [138], 'computer-aided': [140, 256], 'image': [141, 257], 'analysis,': [142], 'numbers': [143], 'adherent': [145], 'platelets,': [146], 'platelet-covered': [147], 'surface,': [148], 'average': [150], 'spread': [152], 'area': [153], 'can': [154], 'be': [155], 'determined': [156], 'markers': [158], 'surface': [160, 216], 'thrombogenicity.': [161], 'To': [162], 'validate': [163], 'technique,': [165], 'four': [166], 'different': [169], 'thrombogenicity': [170, 299], '[polypropylene': [171], '(PP),': [172], 'poly(d,l-lactide)': [173], '(PDLLA),': [174], '2-hydroxyethyl-methacrylate-grafted': [175], 'PDLLA': [176, 203], '(PDLLA–HEMA),': [177], 'heparin-coupled': [179], 'PDLLA–HEMA]': [180], 'were': [181], 'GIFT': [184, 194, 208, 233, 279], 'SEM.': [186], 'We': [187], 'found': [188], 'concordant': [189], 'results': [190], 'SEM': [192, 237], 'following': [197], 'ranking': [198], 'thrombogenicity:': [200], 'PP': [201], '>': [202, 204], 'PDLLA–HEMA': [205], '≥': [206], 'PDLLA-HEMA-heparin.': [207], 'significantly': [209], 'discriminated': [210], 'between': [211], 'modifications': [217], 'led': [218], 'to': [219], 'improved': [220], 'thromboresistance': [221], 'reduced': [223], 'change.': [228], 'main': [230], 'advantages': [231], 'compared': [235], 'are:': [238], 'no': [239], 'vacuum-drying': [240], 'dehydration,': [242], 'less': [243], 'procedure,': [245], 'fixation': [246], '"staining"': [249], 'one': [251], 'step,': [252], 'suitability': [254], 'analysis': [258], 'allowing': [259], 'change': [273], 'high-contrast': [275], 'images.': [276], 'In': [277], 'conclusion,': [278], 'valid,': [282], 'simple': [285], 'determination': [290], 'intended': [294], 'evaluation': [297], 'surfaces.': [302], '©': [303], '2000': [304], 'John': [305], 'Wiley': [306], '&': [307], 'Sons,': [308], 'Inc.': [309], 'J': [310], 'Biomed': [311], 'Mater': [312], 'Res,': [313], '52,': [314], '374–381,': [315], '2000.': [316]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2158334499', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-09-11T16:09:50.887297', 'created_date': '2016-06-24'}