Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2158332968', 'doi': 'https://doi.org/10.1182/blood.v100.5.1543.h81702001543_1543_1550', 'title': 'Characterization of the binding site on heparan sulfate for macrophage inflammatory protein 1α', 'display_name': 'Characterization of the binding site on heparan sulfate for macrophage inflammatory protein 1α', 'publication_year': 2002, 'publication_date': '2002-09-01', 'ids': {'openalex': 'https://openalex.org/W2158332968', 'doi': 'https://doi.org/10.1182/blood.v100.5.1543.h81702001543_1543_1550', 'mag': '2158332968', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12176868'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1182/blood.v100.5.1543.h81702001543_1543_1550', 'pdf_url': 'https://ashpublications.org/blood/article-pdf/100/5/1543/453030/h81702001543.pdf', 'source': {'id': 'https://openalex.org/S200071133', 'display_name': 'Blood', 'issn_l': '0006-4971', 'issn': ['0006-4971', '1528-0020'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://ashpublications.org/blood/article-pdf/100/5/1543/453030/h81702001543.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004858376', 'display_name': 'Sally E. Stringer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129527', 'display_name': 'Cancer Research UK Manchester Institute', 'ror': 'https://ror.org/037405c78', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210129527']}, {'id': 'https://openalex.org/I4210143228', 'display_name': 'The Beatson Institute for Cancer Research', 'ror': 'https://ror.org/03pv69j64', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210143228']}, {'id': 'https://openalex.org/I65163767', 'display_name': 'National Institute for Biological Standards and Control', 'ror': 'https://ror.org/03dnc6n82', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I65163767']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Sally E. Stringer', 'raw_affiliation_strings': ['From the Paterson Institute for Cancer Research, Manchester', 'From the Paterson Institute for Cancer Research, Manchester; the National Institute for Biological Standards and Control, Potters Bar; and the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'the Beatson Institute for Cancer Research, Glasgow, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'From the Paterson Institute for Cancer Research, Manchester', 'institution_ids': ['https://openalex.org/I4210129527']}, {'raw_affiliation_string': 'the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'institution_ids': ['https://openalex.org/I4210143228']}, {'raw_affiliation_string': 'From the Paterson Institute for Cancer Research, Manchester; the National Institute for Biological Standards and Control, Potters Bar; and the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'institution_ids': ['https://openalex.org/I4210143228', 'https://openalex.org/I65163767', 'https://openalex.org/I4210129527']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031539146', 'display_name': 'Mark J. Forster', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129527', 'display_name': 'Cancer Research UK Manchester Institute', 'ror': 'https://ror.org/037405c78', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210129527']}, {'id': 'https://openalex.org/I4210143228', 'display_name': 'The Beatson Institute for Cancer Research', 'ror': 'https://ror.org/03pv69j64', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210143228']}, {'id': 'https://openalex.org/I65163767', 'display_name': 'National Institute for Biological Standards and Control', 'ror': 'https://ror.org/03dnc6n82', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I65163767']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Mark J. Forster', 'raw_affiliation_strings': ['From the Paterson Institute for Cancer Research, Manchester', 'From the Paterson Institute for Cancer Research, Manchester; the National Institute for Biological Standards and Control, Potters Bar; and the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'the Beatson Institute for Cancer Research, Glasgow, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'From the Paterson Institute for Cancer Research, Manchester', 'institution_ids': ['https://openalex.org/I4210129527']}, {'raw_affiliation_string': 'the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'institution_ids': ['https://openalex.org/I4210143228']}, {'raw_affiliation_string': 'From the Paterson Institute for Cancer Research, Manchester; the National Institute for Biological Standards and Control, Potters Bar; and the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'institution_ids': ['https://openalex.org/I4210143228', 'https://openalex.org/I65163767', 'https://openalex.org/I4210129527']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066607321', 'display_name': 'Barbara Mulloy', 'orcid': 'https://orcid.org/0000-0003-3894-7622'}, 'institutions': [{'id': 'https://openalex.org/I4210129527', 'display_name': 'Cancer Research UK Manchester Institute', 'ror': 'https://ror.org/037405c78', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210129527']}, {'id': 'https://openalex.org/I4210143228', 'display_name': 'The Beatson Institute for Cancer Research', 'ror': 'https://ror.org/03pv69j64', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210143228']}, {'id': 'https://openalex.org/I65163767', 'display_name': 'National Institute for Biological Standards and Control', 'ror': 'https://ror.org/03dnc6n82', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I65163767']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Barbara Mulloy', 'raw_affiliation_strings': ['From the Paterson Institute for Cancer Research, Manchester', 'From the Paterson Institute for Cancer Research, Manchester; the National Institute for Biological Standards and Control, Potters Bar; and the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'the Beatson Institute for Cancer Research, Glasgow, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'From the Paterson Institute for Cancer Research, Manchester; the National Institute for Biological Standards and Control, Potters Bar; and the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'institution_ids': ['https://openalex.org/I4210129527', 'https://openalex.org/I4210143228', 'https://openalex.org/I65163767']}, {'raw_affiliation_string': 'From the Paterson Institute for Cancer Research, Manchester', 'institution_ids': ['https://openalex.org/I4210129527']}, {'raw_affiliation_string': 'the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'institution_ids': ['https://openalex.org/I4210143228']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040884235', 'display_name': 'Christopher R. Bishop', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210143228', 'display_name': 'The Beatson Institute for Cancer Research', 'ror': 'https://ror.org/03pv69j64', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210143228']}, {'id': 'https://openalex.org/I65163767', 'display_name': 'National Institute for Biological Standards and Control', 'ror': 'https://ror.org/03dnc6n82', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I65163767']}, {'id': 'https://openalex.org/I4210129527', 'display_name': 'Cancer Research UK Manchester Institute', 'ror': 'https://ror.org/037405c78', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210129527']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Christopher R. Bishop', 'raw_affiliation_strings': ['From the Paterson Institute for Cancer Research, Manchester', 'From the Paterson Institute for Cancer Research, Manchester; the National Institute for Biological Standards and Control, Potters Bar; and the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'the Beatson Institute for Cancer Research, Glasgow, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'From the Paterson Institute for Cancer Research, Manchester; the National Institute for Biological Standards and Control, Potters Bar; and the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'institution_ids': ['https://openalex.org/I4210143228', 'https://openalex.org/I65163767', 'https://openalex.org/I4210129527']}, {'raw_affiliation_string': 'From the Paterson Institute for Cancer Research, Manchester', 'institution_ids': ['https://openalex.org/I4210129527']}, {'raw_affiliation_string': 'the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'institution_ids': ['https://openalex.org/I4210143228']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027149692', 'display_name': 'Gerard J. Graham', 'orcid': 'https://orcid.org/0000-0002-7801-204X'}, 'institutions': [{'id': 'https://openalex.org/I4210129527', 'display_name': 'Cancer Research UK Manchester Institute', 'ror': 'https://ror.org/037405c78', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210129527']}, {'id': 'https://openalex.org/I4210143228', 'display_name': 'The Beatson Institute for Cancer Research', 'ror': 'https://ror.org/03pv69j64', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210143228']}, {'id': 'https://openalex.org/I65163767', 'display_name': 'National Institute for Biological Standards and Control', 'ror': 'https://ror.org/03dnc6n82', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I65163767']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Gerard J. Graham', 'raw_affiliation_strings': ['From the Paterson Institute for Cancer Research, Manchester', 'From the Paterson Institute for Cancer Research, Manchester; the National Institute for Biological Standards and Control, Potters Bar; and the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'the Beatson Institute for Cancer Research, Glasgow, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'From the Paterson Institute for Cancer Research, Manchester', 'institution_ids': ['https://openalex.org/I4210129527']}, {'raw_affiliation_string': 'the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'institution_ids': ['https://openalex.org/I4210143228']}, {'raw_affiliation_string': 'From the Paterson Institute for Cancer Research, Manchester; the National Institute for Biological Standards and Control, Potters Bar; and the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'institution_ids': ['https://openalex.org/I4210143228', 'https://openalex.org/I65163767', 'https://openalex.org/I4210129527']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5104806497', 'display_name': 'John T. Gallagher', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129527', 'display_name': 'Cancer Research UK Manchester Institute', 'ror': 'https://ror.org/037405c78', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210129527']}, {'id': 'https://openalex.org/I4210143228', 'display_name': 'The Beatson Institute for Cancer Research', 'ror': 'https://ror.org/03pv69j64', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801316944', 'https://openalex.org/I4210143228']}, {'id': 'https://openalex.org/I65163767', 'display_name': 'National Institute for Biological Standards and Control', 'ror': 'https://ror.org/03dnc6n82', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I65163767']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'John T. Gallagher', 'raw_affiliation_strings': ['From the Paterson Institute for Cancer Research, Manchester', 'From the Paterson Institute for Cancer Research, Manchester; the National Institute for Biological Standards and Control, Potters Bar; and the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'the Beatson Institute for Cancer Research, Glasgow, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'From the Paterson Institute for Cancer Research, Manchester', 'institution_ids': ['https://openalex.org/I4210129527']}, {'raw_affiliation_string': 'the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'institution_ids': ['https://openalex.org/I4210143228']}, {'raw_affiliation_string': 'From the Paterson Institute for Cancer Research, Manchester; the National Institute for Biological Standards and Control, Potters Bar; and the Beatson Institute for Cancer Research, Glasgow, United Kingdom.', 'institution_ids': ['https://openalex.org/I4210143228', 'https://openalex.org/I65163767', 'https://openalex.org/I4210129527']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5000, 'currency': 'USD', 'value_usd': 5000, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.136, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 72, 'citation_normalized_percentile': {'value': 0.754701, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '100', 'issue': '5', 'first_page': '1543', 'last_page': '1550'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11131', 'display_name': 'Role of Extracellular Matrix in Biological Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11131', 'display_name': 'Role of Extracellular Matrix in Biological Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation in Health and Disease', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Thrombosis Mechanisms', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/heparan-sulfate', 'display_name': 'Heparan Sulfate', 'score': 0.489432}], 'concepts': [{'id': 'https://openalex.org/C2778041096', 'wikidata': 'https://www.wikidata.org/wiki/Q424668', 'display_name': 'Heparan sulfate', 'level': 3, 'score': 0.80576086}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.5140122}, {'id': 'https://openalex.org/C51639874', 'wikidata': 'https://www.wikidata.org/wiki/Q167149', 'display_name': 'Plasma protein binding', 'level': 2, 'score': 0.5096922}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4784158}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.46871915}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.44448966}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4255556}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40333962}, {'id': 'https://openalex.org/C2777557582', 'wikidata': 'https://www.wikidata.org/wiki/Q190016', 'display_name': 'Heparin', 'level': 2, 'score': 0.28094938}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1182/blood.v100.5.1543.h81702001543_1543_1550', 'pdf_url': 'https://ashpublications.org/blood/article-pdf/100/5/1543/453030/h81702001543.pdf', 'source': {'id': 'https://openalex.org/S200071133', 'display_name': 'Blood', 'issn_l': '0006-4971', 'issn': ['0006-4971', '1528-0020'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1182/blood.v100.5.1543.h81702001543_1543_1550', 'pdf_url': 'https://ashpublications.org/blood/article-pdf/100/5/1543/453030/h81702001543.pdf', 'source': {'id': 'https://openalex.org/S200071133', 'display_name': 'Blood', 'issn_l': '0006-4971', 'issn': ['0006-4971', '1528-0020'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.66}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1572034510', 'https://openalex.org/W1591986747', 'https://openalex.org/W1607295833', 'https://openalex.org/W1608390571', 'https://openalex.org/W174862437', 'https://openalex.org/W1877090369', 'https://openalex.org/W1972078597', 'https://openalex.org/W1983190072', 'https://openalex.org/W1983690104', 'https://openalex.org/W1991261634', 'https://openalex.org/W1995129608', 'https://openalex.org/W2020818458', 'https://openalex.org/W2022632494', 'https://openalex.org/W2023021192', 'https://openalex.org/W2029262446', 'https://openalex.org/W2029377282', 'https://openalex.org/W2032833950', 'https://openalex.org/W2040275463', 'https://openalex.org/W2041420763', 'https://openalex.org/W2050820037', 'https://openalex.org/W2051163038', 'https://openalex.org/W2052739114', 'https://openalex.org/W2052900120', 'https://openalex.org/W2055378629', 'https://openalex.org/W2065283382', 'https://openalex.org/W2067422836', 'https://openalex.org/W2080182849', 'https://openalex.org/W2085753643', 'https://openalex.org/W2088437361', 'https://openalex.org/W2094210266', 'https://openalex.org/W2107675979', 'https://openalex.org/W2116857429', 'https://openalex.org/W2120445716', 'https://openalex.org/W2122715437', 'https://openalex.org/W2138339490', 'https://openalex.org/W2146023328', 'https://openalex.org/W2148727539', 'https://openalex.org/W2254087424', 'https://openalex.org/W2346320832', 'https://openalex.org/W2399348675', 'https://openalex.org/W2404037670', 'https://openalex.org/W279078309', 'https://openalex.org/W329540900', 'https://openalex.org/W4238241731', 'https://openalex.org/W4252749216', 'https://openalex.org/W4253951821', 'https://openalex.org/W4301859617', 'https://openalex.org/W4313422358', 'https://openalex.org/W47249135', 'https://openalex.org/W588429086'], 'related_works': ['https://openalex.org/W2951275810', 'https://openalex.org/W2528170488', 'https://openalex.org/W2462655579', 'https://openalex.org/W2337329154', 'https://openalex.org/W2328917962', 'https://openalex.org/W2287683639', 'https://openalex.org/W2097544532', 'https://openalex.org/W2073626691', 'https://openalex.org/W1973479917', 'https://openalex.org/W1570348606'], 'abstract_inverted_index': {'The': [0, 21, 63, 86, 108], 'CC': [1], 'chemokine': [2], 'macrophage': [3], 'inflammatory': [4], 'protein': [5], '1α': [6], '(MIP1α)': [7], 'is': [8, 183], 'a': [9, 103, 134], 'key': [10], 'regulator': [11], 'of': [12, 17, 23, 39, 61, 90, 97, 111, 140, 184, 200, 204, 207, 219], 'the': [13, 40, 58, 74, 130, 138, 141, 144, 179, 189, 201, 205, 208], 'proliferation': [14], 'and': [15, 44, 167, 170, 177], 'differentiation': [16], 'hematopoietic': [18], 'progenitor': [19], 'cells.': [20], 'activity': [22], 'MIP1α': [24, 67, 131, 176, 212], 'appears': [25, 94], 'to': [26, 32, 95, 115, 118, 158, 187, 192, 194, 216, 234], 'be': [27, 116, 232], 'modulated': [28], 'by': [29, 83, 102], 'its': [30, 221], 'binding': [31, 125], 'heparan': [33], 'sulfate': [34], '(HS)': [35], 'proteoglycans,': [36], 'ubiquitous': [37], 'components': [38], 'mammalian': [41], 'cell': [42, 227], 'surface': [43], 'extracellular': [45], 'matrix.': [46], 'In': [47], 'this': [48, 91, 124], 'study': [49], 'we': [50], 'show': [51], 'that': [52, 123, 153, 178], 'HS': [53, 75, 92], 'has': [54], 'highest': [55], 'affinity': [56], 'for': [57, 211], 'dimeric': [59, 65], 'form': [60], 'MIP1α.': [62], 'predominantly': [64], 'BB10010': [66], 'interacts': [68], 'with': [69, 143, 160, 172], 'an': [70], '8.3-kDa': [71], 'sequence': [72], 'in': [73, 133], 'polysaccharide': [76], 'chain,': [77], 'which': [78, 230], 'it': [79], 'protects': [80], 'from': [81], 'degradation': [82], 'heparinase': [84], 'enzymes.': [85], 'major': [87], 'structural': [88], 'motif': [89], 'fragment': [93, 126], 'consist': [96], '2': [98, 190], 'sulfate-rich': [99], 'S-domains': [100, 113, 142, 155, 191], 'separated': [101], 'short': [104], 'central': [105], 'N-acetylated': [106, 181], 'region.': [107], 'optimum': [109], 'lengths': [110], 'these': [112, 154, 195], 'seem': [114], '12': [117], '14': [119], 'saccharides.': [120], 'We': [121], 'propose': [122], 'may': [127, 213], 'wrap': [128], 'around': [129], 'dimer': [132], 'horseshoe': [135], 'shape,': [136], 'facilitating': [137], 'interaction': [139], 'heparin-binding': [145], 'domains': [146], 'on': [147, 175, 197], 'each': [148], 'monomer.': [149], 'Molecular': [150], 'modeling': [151], 'suggests': [152], 'are': [156], 'likely': [157], 'interact': [159], 'basic': [161], 'residues': [162], 'Arg': [163, 165, 168], '17,': [164], '45,': [166], '47': [169], 'possibly': [171], 'Lys': [173], '44': [174], 'interconnecting': [180], 'region': [182], 'sufficient': [185], 'length': [186], 'allow': [188], 'bind': [193], 'sites': [196], 'opposite': [198], 'faces': [199], 'dimer.': [202], 'Elucidation': [203], 'structure': [206], 'HS-binding': [209], 'site': [210], 'enable': [214], 'us': [215], 'devise': [217], 'ways': [218], 'enhancing': [220], 'myeloprotective': [222], 'or': [223], 'peripheral': [224], 'blood': [225], 'stem': [226], 'mobilization': [228], 'properties,': [229], 'can': [231], 'used': [233], 'improve': [235], 'cancer': [236], 'chemotherapy': [237], 'treatments.': [238]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2158332968', 'counts_by_year': [{'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-09-16T16:42:38.130845', 'created_date': '2016-06-24'}