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'mRNA': [23, 56, 110, 124, 131, 181], 'degradation': [24, 182], 'enzymes.': [25], 'Mammalian': [26], 'are': [28], 'also': [29], 'marked': [30], 'GW182': [33, 51, 76, 83, 101, 138, 163, 175], 'protein,': [34], 'interacts': [36], 'AGOs': [39], 'and': [40, 109, 126, 187], 'required': [42], 'for': [43, 97], 'miRNA': [44, 71, 80, 178, 196], 'function.': [45], 'We': [46, 154], 'show': [47, 156], 'that': [48, 75, 157, 174], 'depletion': [49], 'leads': [52], 'changes': [54, 105], 'in': [55, 64, 78, 106, 143], 'profiles': [58], 'strikingly': [59], 'similar': [60], 'those': [62], 'observed': [63], 'cells': [65, 144], 'depleted': [66, 145], 'essential': [69], 'Drosophila': [70], 'effector': [72], 'AGO1,': [73], 'indicating': [74], 'functions': [77], 'pathway.': [81], 'When': [82], 'bound': [85], 'a': [87, 193], 'reporter': [88], 'transcript,': [89], 'it': [90], 'silences': [91], 'its': [92], 'expression,': [93], 'bypassing': [94], 'requirement': [96], 'AGO1.': [98, 170], 'Silencing': [99], 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