Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2157958096', 'doi': 'https://doi.org/10.1210/en.2005-1208', 'title': 'Expression of Growth Differentiation Factor 9 in the Oocytes Is Essential for the Development of Primordial Follicles in the Hamster Ovary', 'display_name': 'Expression of Growth Differentiation Factor 9 in the Oocytes Is Essential for the Development of Primordial Follicles in the Hamster Ovary', 'publication_year': 2005, 'publication_date': '2005-12-30', 'ids': {'openalex': 'https://openalex.org/W2157958096', 'doi': 'https://doi.org/10.1210/en.2005-1208', 'mag': '2157958096', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16384866'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/en.2005-1208', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/147/4/1725/9029434/endo1725.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/endo/article-pdf/147/4/1725/9029434/endo1725.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100416984', 'display_name': 'Cheng Wang', 'orcid': 'https://orcid.org/0000-0002-0911-8254'}, 'institutions': [{'id': 'https://openalex.org/I59130452', 'display_name': 'University of Nebraska Medical Center', 'ror': 'https://ror.org/00thqtb16', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I59130452']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cheng Wang', 'raw_affiliation_strings': ['Departments of Obstetrics and Gynecology (C.W., S.K.R.), University of Nebraska Medical Center, Omaha, Nebraska 68198-4515'], 'affiliations': [{'raw_affiliation_string': 'Departments of Obstetrics and Gynecology (C.W., S.K.R.), University of Nebraska Medical Center, Omaha, Nebraska 68198-4515', 'institution_ids': ['https://openalex.org/I59130452']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5043667168', 'display_name': 'Shyamal K. Roy', 'orcid': 'https://orcid.org/0000-0002-4746-9602'}, 'institutions': [{'id': 'https://openalex.org/I59130452', 'display_name': 'University of Nebraska Medical Center', 'ror': 'https://ror.org/00thqtb16', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I59130452']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Shyamal K. Roy', 'raw_affiliation_strings': ['Cellular and Integrated Physiology (S.K.R.), University of Nebraska Medical Center, Omaha, Nebraska 68198-4515', 'Departments of Obstetrics and Gynecology (C.W., S.K.R.), University of Nebraska Medical Center, Omaha, Nebraska 68198-4515'], 'affiliations': [{'raw_affiliation_string': 'Cellular and Integrated Physiology (S.K.R.), University of Nebraska Medical Center, Omaha, Nebraska 68198-4515', 'institution_ids': ['https://openalex.org/I59130452']}, {'raw_affiliation_string': 'Departments of Obstetrics and Gynecology (C.W., S.K.R.), University of Nebraska Medical Center, Omaha, Nebraska 68198-4515', 'institution_ids': ['https://openalex.org/I59130452']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5043667168'], 'corresponding_institution_ids': ['https://openalex.org/I59130452'], 'apc_list': {'value': 3400, 'currency': 'USD', 'value_usd': 3400, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.754, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 51, 'citation_normalized_percentile': {'value': 0.893246, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '147', 'issue': '4', 'first_page': '1725', 'last_page': '1734'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10364', 'display_name': 'Reproductive Biology and Fertility', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10364', 'display_name': 'Reproductive Biology and Fertility', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10505', 'display_name': 'Pluripotent Stem Cells Research', 'score': 0.9914, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12140', 'display_name': 'Renal and related cancers', 'score': 0.9866, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/growth-differentiation-factor-9', 'display_name': 'Growth differentiation factor-9', 'score': 0.68948495}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.72158283}, {'id': 'https://openalex.org/C5512455', 'wikidata': 'https://www.wikidata.org/wiki/Q2142940', 'display_name': 'Folliculogenesis', 'level': 4, 'score': 0.70204157}, {'id': 'https://openalex.org/C2779192323', 'wikidata': 'https://www.wikidata.org/wiki/Q14876882', 'display_name': 'Growth differentiation factor-9', 'level': 5, 'score': 0.68948495}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.66951275}, {'id': 'https://openalex.org/C22615655', 'wikidata': 'https://www.wikidata.org/wiki/Q203221', 'display_name': 'Small interfering RNA', 'level': 4, 'score': 0.6319295}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.56144917}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.52062273}, {'id': 'https://openalex.org/C2778324911', 'wikidata': 'https://www.wikidata.org/wiki/Q9631', 'display_name': 'Ovary', 'level': 2, 'score': 0.49368486}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.48722187}, {'id': 'https://openalex.org/C2778575167', 'wikidata': 'https://www.wikidata.org/wiki/Q6573', 'display_name': 'Hamster', 'level': 2, 'score': 0.4381564}, {'id': 'https://openalex.org/C148738053', 'wikidata': 'https://www.wikidata.org/wiki/Q210861', 'display_name': 'Cellular differentiation', 'level': 3, 'score': 0.42163345}, {'id': 'https://openalex.org/C175805485', 'wikidata': 'https://www.wikidata.org/wiki/Q2367166', 'display_name': 'Theca', 'level': 3, 'score': 0.41800028}, {'id': 'https://openalex.org/C2777216303', 'wikidata': 'https://www.wikidata.org/wiki/Q866324', 'display_name': 'Hair follicle', 'level': 2, 'score': 0.4143917}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.41430748}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.24497914}, {'id': 'https://openalex.org/C87073359', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryogenesis', 'level': 3, 'score': 0.15677205}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.15429547}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.12887675}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07162115}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.054226696}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006080', 'descriptor_name': 'Ovarian Follicle', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005640', 'descriptor_name': 'Follicle Stimulating Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005640', 'descriptor_name': 'Follicle Stimulating Hormone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D055429', 'descriptor_name': 'Growth Differentiation Factor 9', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008647', 'descriptor_name': 'Mesocricetus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006080', 'descriptor_name': 'Ovarian Follicle', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006080', 'descriptor_name': 'Ovarian Follicle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/en.2005-1208', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/147/4/1725/9029434/endo1725.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16384866', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/en.2005-1208', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/147/4/1725/9029434/endo1725.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1501777420', 'https://openalex.org/W15453418', 'https://openalex.org/W1968446974', 'https://openalex.org/W1983309364', 'https://openalex.org/W1993075625', 'https://openalex.org/W1996938657', 'https://openalex.org/W2001396014', 'https://openalex.org/W2005271852', 'https://openalex.org/W2011253631', 'https://openalex.org/W2018831893', 'https://openalex.org/W2019387053', 'https://openalex.org/W2024805700', 'https://openalex.org/W2035979154', 'https://openalex.org/W2038783205', 'https://openalex.org/W2039028947', 'https://openalex.org/W2039707872', 'https://openalex.org/W2040525542', 'https://openalex.org/W2041944050', 'https://openalex.org/W2049004724', 'https://openalex.org/W2050954429', 'https://openalex.org/W2055917035', 'https://openalex.org/W2060032066', 'https://openalex.org/W2061064143', 'https://openalex.org/W2080036473', 'https://openalex.org/W2081374834', 'https://openalex.org/W2097893055', 'https://openalex.org/W2098432765', 'https://openalex.org/W2102351611', 'https://openalex.org/W2113746705', 'https://openalex.org/W2126241980', 'https://openalex.org/W2135104064', 'https://openalex.org/W2139604292', 'https://openalex.org/W2147629399', 'https://openalex.org/W2148839199', 'https://openalex.org/W2158140769', 'https://openalex.org/W2166932843', 'https://openalex.org/W2168337336', 'https://openalex.org/W4253213125'], 'related_works': ['https://openalex.org/W3032894235', 'https://openalex.org/W2382336265', 'https://openalex.org/W2358796690', 'https://openalex.org/W2349975574', 'https://openalex.org/W2288457010', 'https://openalex.org/W2130871836', 'https://openalex.org/W2058173491', 'https://openalex.org/W2028609588', 'https://openalex.org/W1999470156', 'https://openalex.org/W1975538109'], 'abstract_inverted_index': {'Postnatal': [0], 'growth': [1], 'differentiation': [2, 220], 'factor': [3], '9': [4, 47], '(GDF-9)': [5], 'expression': [6], 'in': [7, 24, 27, 87, 110, 217], 'the': [8, 12, 19, 28, 74, 88, 111, 118, 121, 130, 143, 148, 156, 170, 200, 222], 'hamster': [9, 29], 'oocytes': [10], 'precedes': [11], 'formation': [13, 223], 'of': [14, 22, 35, 76, 82, 108, 133, 150, 172, 224, 231, 238], 'primordial': [15, 25, 77, 196, 225, 239], 'follicles.': [16, 226], 'We': [17], 'examined': [18], 'functional': [20], 'significance': [21], 'GDF-9': [23, 36, 66, 69, 134, 137, 151, 162, 165, 181, 186, 191, 205, 212, 233], 'folliculogenesis': [26], 'ovary': [30, 112], 'using': [31], 'RNA': [32, 64], 'interference': [33], 'knockdown': [34], 'mRNA': [37, 152], 'and': [38, 73, 116, 153, 155, 221], 'protein': [39, 175, 187], 'expression.': [40, 188], 'Fifteen-day-old': [41], 'fetal': [42], 'ovaries': [43, 95], 'were': [44, 113], 'cultured': [45], 'for': [46], 'd': [48], 'with': [49, 96, 103, 190], 'or': [50, 68, 178], 'without': [51], '1': [52, 55], 'ng': [53], 'FSH,': [54, 72, 228], 'μl': [56], 'Metafectane,': [57], '100': [58], 'nm': [59], 'control': [60, 100], 'nontargeting': [61, 99], 'small': [62], 'interfering': [63], '(siRNA),': [65], 'siRNA,': [67], 'siRNA': [70, 83, 101, 126, 138, 166, 182], '+': [71], 'development': [75], 'follicles': [78, 240], 'examined.': [79], 'The': [80], 'efficiency': [81], 'transfecting': [84], 'ovarian': [85], 'cells': [86, 109], 'organ': [89], 'culture': [90], 'was': [91, 158, 202], 'tested': [92], 'by': [93, 161, 204, 229], 'culturing': [94], 'siGlo,': [97], 'a': [98], 'labeled': [102], 'Cy3.': [104], 'More': [105], 'than': [106], '90%': [107], 'siGlo': [114], 'positive,': [115], 'neither': [117], 'Metafectane': [119], 'nor': [120], 'siRNA-induced': [122], 'cellular': [123], 'apoptosis.': [124], 'Control': [125], 'did': [127, 167], 'not': [128, 168], 'affect': [129, 169], 'basal': [131], 'levels': [132, 149, 171], 'mRNA,': [135], 'but': [136, 140, 199], 'slightly': [139], 'significantly': [141, 194], 'reduced': [142, 185], 'level.': [144], 'FSH': [145, 193], 'markedly': [146], 'up-regulated': [147], 'protein,': [154], 'effect': [157, 201], 'completely': [159], 'suppressed': [160], 'siRNA.': [163, 206], 'However,': [164], 'bone': [173], 'morphogenetic': [174], 'receptor': [176], 'IA': [177], 'β-actin': [179], 'mRNA.': [180], 'alone': [183], 'also': [184], 'Concurrent': [189], 'expression,': [192, 234], 'augmented': [195], 'follicle': [197], 'formation,': [198], 'abolished': [203], 'These': [207], 'results': [208], 'suggest': [209], 'that': [210], 'endogenous': [211], 'plays': [213], 'an': [214], 'important': [215], 'role': [216], 'somatic': [218], 'cell': [219], 'Furthermore,': [227], 'virtue': [230], 'regulating': [232], 'modulates': [235], 'oocyte': [236], 'regulation': [237], 'formation.': [241]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2157958096', 'counts_by_year': [{'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-07T19:15:39.609963', 'created_date': '2016-06-24'}