Publication Information

{'id': 'https://openalex.org/W2157816812', 'doi': 'https://doi.org/10.1007/s00259-015-3047-0', 'title': 'Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study', 'display_name': 'Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study', 'publication_year': 2015, 'publication_date': '2015-04-16', 'ids': {'openalex': 'https://openalex.org/W2157816812', 'doi': 'https://doi.org/10.1007/s00259-015-3047-0', 'mag': '2157816812', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25893384', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4424277'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00259-015-3047-0', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s00259-015-3047-0.pdf', 'source': {'id': 'https://openalex.org/S191349260', 'display_name': 'European Journal of Nuclear Medicine and Molecular Imaging', 'issn_l': '1619-7070', 'issn': ['1619-7070', '1619-7089'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://link.springer.com/content/pdf/10.1007/s00259-015-3047-0.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5073567803', 'display_name': 'E. Rodriguez-Vieitez', 'orcid': 'https://orcid.org/0000-0002-6639-8141'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Elena Rodriguez-Vieitez', 'raw_affiliation_strings': ['Division of Translational Alzheimer Neurobiology, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum 5th Floor, Blickagången 6, 141 57, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Division of Translational Alzheimer Neurobiology, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum 5th Floor, Blickagången 6, 141 57, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051431217', 'display_name': 'Ruiqing Ni', 'orcid': 'https://orcid.org/0000-0002-0793-2113'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Ruiqing Ni', 'raw_affiliation_strings': ['Division of Translational Alzheimer Neurobiology, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum 5th Floor, Blickagången 6, 141 57, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Division of Translational Alzheimer Neurobiology, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum 5th Floor, Blickagången 6, 141 57, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033422963', 'display_name': 'Balázs Gulyás', 'orcid': 'https://orcid.org/0000-0001-9295-2460'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Balázs Gulyás', 'raw_affiliation_strings': ['Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061219590', 'display_name': 'Miklós Tóth', 'orcid': 'https://orcid.org/0000-0002-1652-7136'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Miklós Tóth', 'raw_affiliation_strings': ['Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042691997', 'display_name': 'Jenny Häggkvist', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Jenny Häggkvist', 'raw_affiliation_strings': ['Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081327813', 'display_name': 'Christer Halldin', 'orcid': 'https://orcid.org/0000-0002-7681-1104'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Christer Halldin', 'raw_affiliation_strings': ['Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005261902', 'display_name': 'Larysa Voytenko', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Larysa Voytenko', 'raw_affiliation_strings': ['Division of Translational Alzheimer Neurobiology, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum 5th Floor, Blickagången 6, 141 57, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Division of Translational Alzheimer Neurobiology, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum 5th Floor, Blickagången 6, 141 57, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074092299', 'display_name': 'Amelia Marutle', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Amelia Marutle', 'raw_affiliation_strings': ['Division of Translational Alzheimer Neurobiology, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum 5th Floor, Blickagången 6, 141 57, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Division of Translational Alzheimer Neurobiology, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum 5th Floor, Blickagången 6, 141 57, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5089411086', 'display_name': 'Agneta Nordberg', 'orcid': 'https://orcid.org/0000-0001-7345-5151'}, 'institutions': [{'id': 'https://openalex.org/I1335113835', 'display_name': 'Karolinska University Hospital', 'ror': 'https://ror.org/00m8d6786', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1335113835']}], 'countries': ['SE'], 'is_corresponding': True, 'raw_author_name': 'Agneta Nordberg', 'raw_affiliation_strings': ['Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I1335113835']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5089411086'], 'corresponding_institution_ids': ['https://openalex.org/I1335113835'], 'apc_list': {'value': 3890, 'currency': 'EUR', 'value_usd': 4990, 'provenance': 'doaj'}, 'apc_paid': {'value': 3890, 'currency': 'EUR', 'value_usd': 4990, 'provenance': 'doaj'}, 'fwci': 6.633, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 134, 'citation_normalized_percentile': {'value': 0.999954, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '42', 'issue': '7', 'first_page': '1119', 'last_page': '1132'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11335', 'display_name': 'Prion Diseases and Protein Misfolding', 'score': 0.985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10009', 'display_name': 'Dementia and Cognitive Impairment Research', 'score': 0.9741, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/astrocytosis', 'display_name': 'Astrocytosis', 'score': 0.9481424}, {'id': 'https://openalex.org/keywords/correlative', 'display_name': 'Correlative', 'score': 0.4332472}, {'id': 'https://openalex.org/keywords/amyloid', 'display_name': 'Amyloid (mycology)', 'score': 0.4263559}], 'concepts': [{'id': 'https://openalex.org/C2908656565', 'wikidata': 'https://www.wikidata.org/wiki/Q4811564', 'display_name': 'Astrocytosis', 'level': 3, 'score': 0.9481424}, {'id': 'https://openalex.org/C2775842073', 'wikidata': 'https://www.wikidata.org/wiki/Q208376', 'display_name': 'Positron emission tomography', 'level': 2, 'score': 0.7302091}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4557284}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.45546257}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.43852055}, {'id': 'https://openalex.org/C2776800370', 'wikidata': 'https://www.wikidata.org/wiki/Q5172864', 'display_name': 'Correlative', 'level': 2, 'score': 0.4332472}, {'id': 'https://openalex.org/C2777633098', 'wikidata': 'https://www.wikidata.org/wiki/Q2736051', 'display_name': 'Amyloid (mycology)', 'level': 2, 'score': 0.4263559}, {'id': 'https://openalex.org/C2989005', 'wikidata': 'https://www.wikidata.org/wiki/Q214963', 'display_name': 'Nuclear medicine', 'level': 1, 'score': 0.39413014}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.21108058}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0712699}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': True}, {'descriptor_ui': 'D005911', 'descriptor_name': 'Gliosis', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': True}, {'descriptor_ui': 'D058225', 'descriptor_name': 'Plaque, Amyloid', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': True}, {'descriptor_ui': 'D049268', 'descriptor_name': 'Positron-Emission Tomography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000544', 'descriptor_name': 'Alzheimer Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000631', 'descriptor_name': 'Aminopyridines', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D000631', 'descriptor_name': 'Aminopyridines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052160', 'descriptor_name': 'Benzothiazoles', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D052160', 'descriptor_name': 'Benzothiazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002250', 'descriptor_name': 'Carbon Radioisotopes', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D002250', 'descriptor_name': 'Carbon Radioisotopes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005911', 'descriptor_name': 'Gliosis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D005911', 'descriptor_name': 'Gliosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058225', 'descriptor_name': 'Plaque, Amyloid', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D058225', 'descriptor_name': 'Plaque, Amyloid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019275', 'descriptor_name': 'Radiopharmaceuticals', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D019275', 'descriptor_name': 'Radiopharmaceuticals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00259-015-3047-0', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s00259-015-3047-0.pdf', 'source': {'id': 'https://openalex.org/S191349260', 'display_name': 'European Journal of Nuclear Medicine and Molecular Imaging', 'issn_l': '1619-7070', 'issn': ['1619-7070', '1619-7089'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://zenodo.org/record/28212', 'pdf_url': 'https://zenodo.org/records/28212/files/Rodriguez-Vieitez_EurJNuclMedMolImaging_2015_P12b.pdf', 'source': {'id': 'https://openalex.org/S4306400562', 'display_name': 'Zenodo (CERN European Organization for Nuclear Research)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I67311998', 'host_organization_name': 'European Organization for Nuclear Research', 'host_organization_lineage': ['https://openalex.org/I67311998'], 'host_organization_lineage_names': ['European Organization for Nuclear Research'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424277', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25893384', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00259-015-3047-0', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s00259-015-3047-0.pdf', 'source': {'id': 'https://openalex.org/S191349260', 'display_name': 'European Journal of Nuclear Medicine and Molecular Imaging', 'issn_l': '1619-7070', 'issn': ['1619-7070', '1619-7089'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.62, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 63, 'referenced_works': ['https://openalex.org/W1632755291', 'https://openalex.org/W1929267935', 'https://openalex.org/W1968588215', 'https://openalex.org/W1974294728', 'https://openalex.org/W1981546185', 'https://openalex.org/W1988358862', 'https://openalex.org/W1989409633', 'https://openalex.org/W1992230271', 'https://openalex.org/W1994630549', 'https://openalex.org/W1998126371', 'https://openalex.org/W2007698927', 'https://openalex.org/W2009077522', 'https://openalex.org/W2010476270', 'https://openalex.org/W2012601853', 'https://openalex.org/W2018813802', 'https://openalex.org/W2020574854', 'https://openalex.org/W2038337878', 'https://openalex.org/W2039696222', 'https://openalex.org/W2039930606', 'https://openalex.org/W2040446120', 'https://openalex.org/W2042956691', 'https://openalex.org/W2043029471', 'https://openalex.org/W2047585900', 'https://openalex.org/W2054129330', 'https://openalex.org/W2054388625', 'https://openalex.org/W2055129010', 'https://openalex.org/W2065845390', 'https://openalex.org/W2069812964', 'https://openalex.org/W2071196284', 'https://openalex.org/W2075755119', 'https://openalex.org/W2079313884', 'https://openalex.org/W2080274663', 'https://openalex.org/W2081267090', 'https://openalex.org/W2082429191', 'https://openalex.org/W2090930997', 'https://openalex.org/W2093116184', 'https://openalex.org/W2096410114', 'https://openalex.org/W2112193355', 'https://openalex.org/W2116784956', 'https://openalex.org/W2124127229', 'https://openalex.org/W2129771097', 'https://openalex.org/W2133443080', 'https://openalex.org/W2133775490', 'https://openalex.org/W2134711807', 'https://openalex.org/W2144975288', 'https://openalex.org/W2150845749', 'https://openalex.org/W2151137844', 'https://openalex.org/W2151763964', 'https://openalex.org/W2154780300', 'https://openalex.org/W2155009321', 'https://openalex.org/W2158407564', 'https://openalex.org/W2159789463', 'https://openalex.org/W2160881303', 'https://openalex.org/W2162110855', 'https://openalex.org/W2164490896', 'https://openalex.org/W2164979083', 'https://openalex.org/W2166317402', 'https://openalex.org/W2167720733', 'https://openalex.org/W2168664921', 'https://openalex.org/W2171502370', 'https://openalex.org/W2180489978', 'https://openalex.org/W2364611657', 'https://openalex.org/W2365714696'], 'related_works': ['https://openalex.org/W4392395413', 'https://openalex.org/W4234293733', 'https://openalex.org/W2781767786', 'https://openalex.org/W2067437467', 'https://openalex.org/W2039288694', 'https://openalex.org/W2034258079', 'https://openalex.org/W2015290984', 'https://openalex.org/W2013489516', 'https://openalex.org/W1990224041', 'https://openalex.org/W1963775979'], 'abstract_inverted_index': {'Pathological': [0], 'studies': [1], 'suggest': [2], 'that': [3, 297], 'neuroinflammation': [4], 'is': [5], 'exacerbated': [6], 'by': [7, 48, 98, 134], 'increased': [8], 'beta-amyloid': [9], '(Aβ)': [10], 'levels': [11], 'in': [12, 16, 34, 41, 71, 83, 123, 135, 159, 166, 180, 203, 215, 227, 236, 239, 254, 267, 277, 287, 294, 301], 'the': [13, 57, 63, 117, 167, 226, 268, 278], 'brain': [14, 111, 114, 161], 'early': [15, 300], "Alzheimer's": [17], 'disease': [18], '(AD).': [19], 'The': [20, 290], 'time': [21], 'course': [22], 'and': [23, 27, 51, 62, 77, 82, 89, 106, 120, 132, 144, 146, 153, 185, 206, 222, 232, 242, 251, 270, 272], 'relationships': [24], 'between': [25, 249], 'astrocytosis': [26, 133, 298], 'Aβ': [28, 130, 237, 304], 'deposition': [29, 131, 238], 'were': [30, 127, 245], 'examined': [31], 'using': [32, 103, 138], 'multitracer': [33], 'vivo': [35, 228, 295], 'positron': [36], 'emission': [37], 'tomography': [38], '(PET)': [39], 'imaging': [40, 55], 'an': [42], 'AD': [43], 'transgenic': [44], 'mouse': [45, 110], 'model,': [46], 'followed': [47], 'postmortem': [49], 'autoradiography': [50, 137, 220, 256], 'immunohistochemistry': [52], 'analysis.': [53], 'PET': [54, 164, 188], 'with': [56, 149, 230], 'amyloid': [58], 'plaque': [59, 305], 'tracer': [60, 65], '11C-AZD2184': [61, 163, 231], 'astroglial': [64], '11C-deuterium-L-deprenyl': [66], '(11C-DED)': [67], 'was': [68, 96, 173, 190, 208], 'carried': [69], 'out': [70], 'APPswe': [72, 119, 171, 204, 240, 250, 288], 'mice': [73, 86, 122, 172, 253], 'aged': [74, 87], '6,': [75], '8–15': [76, 88, 198, 213], '18–24': [78, 90, 177, 201, 281], 'months': [79, 91, 178, 195, 199, 202, 214, 282, 286], '(4–6': [80], 'animals/group)': [81], 'wild-type': [84], '(wt)': [85], '(3–6': [92], 'animals/group).': [93], 'Tracer': [94], 'uptake': [95], 'quantified': [97], 'region': [99], 'of': [100, 170], 'interest': [101], 'analysis': [102], 'PMOD': [104], 'software': [105], 'a': [107], '3-D': [108], 'digital': [109], 'atlas.': [112], 'Postmortem': [113], 'tissues': [115], 'from': [116], 'same': [118], 'wt': [121, 182, 216, 252], 'all': [124], 'age': [125, 259], 'groups': [126], 'analysed': [128], 'for': [129, 151], 'vitro': [136, 219], '3H-AZD2184,': [139], '3H-Pittsburgh': [140], 'compound': [141], 'B': [142], '(PIB)': [143], '3H-L-deprenyl': [145, 255], 'immunostaining': [147], 'performed': [148], 'antibodies': [150], 'Aβ42': [152, 265], 'glial': [154], 'fibrillary': [155], 'acidic': [156], 'protein': [157], '(GFAP)': [158], 'sagittal': [160], 'sections.': [162], 'retention': [165], 'cerebral': [168], 'cortices': [169], 'significantly': [174, 191], 'higher': [175, 192, 210], 'at': [176, 193, 197, 212, 280, 284], 'than': [179, 196, 211, 283], 'age-matched': [181], 'mice.': [183, 217, 289], 'Cortical': [184], 'hippocampal': [186], '11C-DED': [187], 'binding': [189, 224, 257], '6': [194, 285], 'or': [200], 'mice,': [205], 'it': [207], 'also': [209], 'In': [218], '3H-AZD2184': [221], '3H-PIB': [223], 'confirmed': [225], 'findings': [229, 291], 'demonstrated': [233, 263], 'age-dependent': [234], 'increases': [235], 'cortex': [241, 269], 'hippocampus.': [243], 'There': [244], 'no': [246], 'significant': [247], 'differences': [248], 'across': [258], 'groups.': [260], 'Immunohistochemical': [261], 'quantification': [262], 'more': [264, 273], 'deposits': [266], 'hippocampus': [271, 279], 'GFAP+': [274], 'reactive': [275], 'astrocytes': [276], 'provide': [292], 'further': [293], 'evidence': [296], 'occurs': [299], 'AD,': [302], 'preceding': [303], 'deposition.': [306]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2157816812', 'counts_by_year': [{'year': 2024, 'cited_by_count': 15}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 26}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 7}], 'updated_date': '2024-12-19T10:12:35.050402', 'created_date': '2016-06-24'}