Publication Information

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'published25': [61], 'Oct': [62], '2005https://doi.org/10.1161/CIRCULATIONAHA.105.578146Circulation.': [63], '2005;112:2585–2588The': [64], 'contemporary': [65], 'notion': [66, 599, 1024, 1351], 'that': [67, 97, 118, 150, 235, 244, 288, 400, 435, 492, 609, 793, 919, 978, 1025, 1054, 1064, 1079, 1119, 1136, 1164, 1174, 1227, 1241, 1352, 1387, 1399, 1444, 1453, 1485, 1498, 1510, 1526, 1549, 1571, 1619, 1663, 1748, 1788, 1933, 1959, 2013, 2035, 2074, 2226, 2543], 'oxidative': [68, 119, 2066, 2296, 2898, 3038, 3417, 3560, 3753, 4479], 'stress': [69, 120, 2067, 3039, 3418, 3561, 3754, 4480, 4614], 'contributes': [70, 991, 1027], 'vascular': [72, 98, 123, 166, 325, 335, 392, 436, 528, 637, 745, 756, 763, 780, 841, 888, 931, 939, 1031, 1043, 1152, 1203, 1656, 1817, 2069, 2081, 2087, 2126, 2138, 2449, 2534, 2585, 2671, 2811, 2847, 2872, 2932, 3005, 3035, 3094, 3554, 3709], 'wall': [73, 124, 144, 764, 1153], 'pathology': [74, 2082], 'dates': [75], 'back': [76], 'some': [77], '25': [78], 'years,': [79, 577], 'when': [80], 'chemical': [81, 2024], 'modification': [82], 'LDL': [84, 101, 105, 132, 2445, 3180], 'was': [85, 580, 1296, 1369], 'found': [86, 918, 1711], 'permit': [88], 'macrophage': [89, 2258], 'foam': [90], 'cell': [91, 173, 426, 739, 952, 988, 1008, 1074, 1181, 1530, 1921, 2537, 2935, 3001, 3555], 'formation,1': [92], 'subsequent': [94], 'data': [95, 972, 1046, 1063, 1163, 1381, 1803], 'indicated': [96], 'cells': [99, 167, 385, 638, 713, 904, 4075], 'promoted': [100, 520], 'lipid': [102], 'oxidation': [103, 130], '(eg,': [104, 1114, 1302], 'oxidation)': [106], 'produce': [108, 162, 1960], 'a': [109, 222, 242, 262, 283, 303, 313, 338, 357, 422, 439, 454, 471, 585, 824, 877, 927, 1011, 1093, 1199, 1230, 1234, 1253, 1272, 1397, 1448, 1683, 1745, 1853, 2078, 2488, 2533, 2636, 2894, 2918, 2973, 3876, 4119], 'similarly': [110], 'modified': [111], 'LDL.2': [112], 'It': [113, 1930, 2071], 'is': [114, 213, 218, 360, 394, 453, 542, 623, 720, 767, 787, 791, 819, 1067, 1077, 1290, 1389, 1451, 1508, 1524, 1536, 1548, 1567, 1851, 1882, 1891, 1910, 1948, 1988, 2032, 2072, 2149, 2917, 2967, 4388], 'now': [115, 610, 624, 721], 'clear,': [116], 'however,': [117, 947, 1132], 'in': [121, 165, 189, 268, 415, 489, 589, 636, 647, 668, 684, 712, 762, 776, 846, 862, 901, 911, 923, 930, 1060, 1096, 1161, 1238, 1280, 1346, 1366, 1372, 1465, 1588, 1591, 1634, 1717, 1731, 1751, 1760, 1798, 1827, 1894, 1984, 2001, 2063, 2080, 2093, 2125, 2146, 2170, 2298, 2324, 2367, 2448, 2484, 2494, 2547, 2551, 2554, 2584, 2642, 2670, 2705, 2743, 2815, 2844, 2878, 2931, 2969, 2975, 3004, 3033, 3044, 3065, 3093, 3241, 3281, 3377, 3428, 3515, 3632, 3665, 3686, 3691, 3755, 3849, 3909, 4040, 4070, 4165, 4200, 4266, 4295, 4330, 4362, 4390, 4400, 4481, 4511, 4590], 'involves': [125, 401], 'much': [126, 782], 'more': [127, 2091], 'than': [128, 1206], 'lipids.': [133], 'Risk': [134], 'factors': [135, 523, 4003], 'for': [136, 264, 728, 770, 803, 887, 1069, 1178, 1210, 1392, 1543, 1556, 1903, 2097, 2137, 2162, 2273, 2422, 2426, 2491, 3662, 4203, 4580], 'atherosclerosis': [137, 1059], 'are': [138, 732, 747, 973, 1142, 1175, 1345, 1742, 1859, 2102, 2132, 2173], 'associated': [139, 502, 524, 537, 754, 1246, 4004, 4036], 'with': [140, 491, 503, 525, 538, 562, 602, 641, 656, 735, 755, 835, 864, 949, 965, 967, 975, 1089, 1160, 1233, 1247, 1317, 1349, 1401, 1437, 1467, 1500, 1569, 1573, 1593, 1714, 1734, 1744, 1780, 1840, 1863, 1924, 2108, 2266, 3502, 3757, 4005, 4037, 4078, 4209, 4268, 4364], 'an': [141, 250, 397, 612, 1133, 1489, 1511, 1580, 1669, 2060, 2402, 3429, 3503], 'increased': [142, 1581], 'arterial': [143, 653, 675, 961, 2498], 'flux': [145, 1330, 1495, 1517, 1587, 1605], 'reactive': [147, 209, 291, 411, 450, 465, 485, 511, 534, 932, 981, 1017, 1098, 1125, 1137, 1168, 1186, 1220, 1248, 1327, 1354, 1492, 1514, 1533, 1550, 1584, 1602, 1627, 1665, 1772, 2016, 2039, 2666, 4292], 'oxygen': [148, 210, 292, 412, 451, 466, 486, 512, 535, 933, 982, 1018, 1099, 1126, 1138, 1169, 1187, 1221, 1249, 1328, 1355, 1493, 1515, 1534, 1551, 1585, 1603, 1628, 1666, 1773, 2017, 2040, 4293], 'species': [149, 211, 243, 293, 413, 452, 467, 513, 536, 934, 983, 1019, 1100, 1139, 1222, 1250, 1329, 1356, 1494, 1516, 1535, 1552, 1586, 1604, 1629, 1667, 1774, 2018, 2041, 4294], 'not': [151, 733, 820, 1143, 1370, 1390, 1459, 1852, 2033, 2174], 'only': [152, 588, 1084, 1893], 'may': [153, 433, 1056, 1791, 1819, 2156, 2545], 'oxidize': [154], 'biological': [155], 'targets': [156], '(ie,': [157], 'lipids),': [158], 'but': [159, 1560, 1764], 'also': [160, 1130], 'directly': [161], 'phenotypic': [163, 286, 1244, 2047], 'changes': [164, 1797], 'such': [168, 403, 2019], 'as': [169, 249, 294, 345, 388, 404, 584, 626, 723, 963, 1010, 1194, 2020, 2396], 'inducing': [170], 'smooth': [171, 277, 383, 424, 902, 924, 950, 986, 1006, 1072, 1179, 1528, 1895, 1919, 2535, 2586, 2812, 2933, 3006, 3095, 4043, 4403], 'muscle': [172, 384, 425, 903, 925, 951, 987, 1007, 1073, 1180, 1529, 1896, 1920, 2536, 2587, 2813, 2934, 3096, 4044, 4404], 'proliferation,': [174], 'adhesion': [175], 'molecule': [176, 1232], 'expression,': [177], 'premature': [179, 3906], 'senescence.3': [180], 'Many': [181], 'these': [183, 657, 812, 1105, 1415, 1647, 1740, 1802, 1934, 2112, 2147], 'cellular': [184, 204, 318, 410, 447, 531, 1212, 1968], 'responses': [185, 287, 319, 342, 519, 1173, 1245, 1699], 'have': [186, 851, 856, 1668, 1695, 1757], 'been': [187, 666, 909], 'implicated': [188, 667, 910], 'both': [190, 1176, 1325, 1625, 1660, 1693, 1770], 'development': [192, 1822, 3320], 'clinical': [195], 'manifestations': [196], 'atherosclerosis.Articles': [198], 'pp': [199], '2668': [200], '2677In': [202], 'environment,': [205], 'most': [207], 'common': [208], 'produced': [212, 926, 1518, 1579], 'superoxide': [214, 233, 237, 571, 708, 1117, 2593], '(O2·−)': [215, 709], 'because': [216, 1856], 'it': [217, 790, 1076, 1295, 1450, 1483, 1507, 1523, 1808, 2006, 2031], 'product': [220], 'single': [223, 586], 'electron': [224], 'added': [225], 'oxygen.': [227], 'Cells': [228], 'tissues': [230], 'contain': [231], 'abundant': [232, 1951], 'dismutase': [234], 'converts': [236], 'hydrogen': [239, 715, 2999], 'peroxide': [240], '(H2O2),': [241], 'has': [245, 469, 665, 908], 'garnered': [246], 'considerable': [247, 474, 768, 1435], 'interest': [248], 'endogenous': [251], 'signaling': [252, 295, 488, 1231, 1965, 2597, 2924, 3427], 'molecule.': [253, 1966], 'A': [254, 3174, 3746, 3834, 4155, 4215, 4286, 4587], 'landmark': [255], 'study': [256, 1266, 1299, 1443, 1478, 2974], 'by': [257, 298, 362, 396, 521, 752, 1000, 1047, 1107, 1261, 1267, 1282, 1382, 1950, 2027, 2271, 2540, 2647, 2927, 3141, 3213, 3327, 3562, 4116, 4258, 4544], 'Sundaresan': [258, 2411], 'colleagues7': [260], 'demonstrated': [261, 955, 1662, 1726], 'requirement': [263], 'intracellular': [265, 290, 1871, 4397], 'H2O2': [266, 2021, 2425, 2843], 'generation': [267, 448, 572, 2423], 'mitogenic': [270], 'effects': [271, 483, 1701], 'platelet-derived': [273, 2427], 'growth': [274, 522, 2428], 'factor': [275, 2429], 'on': [276, 559, 829, 1202, 1291, 1310, 1476, 1671, 1702, 1737, 1953, 1977, 2224, 3276, 3461, 4396], 'muscle.': [278, 3007], 'Subsequent': [279], 'investigation': [280], 'points': [281], 'host': [284, 742], 'involve': [289], 'molecules': [296], '(reviewed': [297, 2026], 'Chen': [299, 2028, 2437, 2460, 3304, 3349, 3933, 4022, 4099], 'et': [300, 1724, 2029], 'al8).': [301], 'As': [302, 823], 'result': [304], 'this': [306, 328, 430, 458, 578, 632, 662, 847, 860, 906, 1184, 1215, 1376, 1505, 1643, 1828, 2154, 2171, 2549], 'body': [307], 'work,': [309], 'one': [310, 432], 'can': [311, 1409, 1973, 2114], 'construct': [312], 'paradigm': [314, 690], '(Figure': [315, 573, 639, 1251, 1868], '1)': [316], 'relating': [317, 2065], 'phenotype': [322, 501, 1204], 'wall.': [326], 'In': [327, 390, 509, 737, 890, 941, 1214, 1441, 1504, 1691, 1705, 1906, 1997], 'model,': [329], 'presence': [331], 'or': [332, 348, 1197, 2105, 2180, 3505], 'absence': [333, 1719], 'disease': [336, 393, 437], 'represents': [337, 438], 'balance': [339], 'between': [340, 1546, 3179], 'tissue': [341], 'typically': [343, 516], 'categorized': [344], 'either': [346, 1195, 2103], 'normal': [347, 358, 507, 968, 1574], 'related': [349], 'injury.': [351, 676, 757, 2499, 2747], 'With': [352, 1875, 4328, 4592], 'regard': [353, 836, 865, 1438, 1841, 1876], 'former,': [356, 1879], 'vasculature': [359, 1240], 'characterized': [361, 395], 'laminar': [363, 504], 'flow,': [364], 'endothelial': [365, 1907, 2268, 2326, 2403, 3067, 3630, 3872, 4074], 'elaboration': [366], 'nitric': [368, 494, 3145], 'oxide': [369, 3137, 3146], '(NO·),': [370], 'resultant': [373, 2046], 'vasodilation,': [374], 'inhibition': [375], 'platelet': [377, 4358], 'adhesion,': [378], 'low': [379, 2233, 2261, 2275], 'matrix': [380, 419], 'turnover,': [381, 420], 'historically': [386], 'described': [387], '"quiescent."': [389], 'contrast,': [391, 510, 1998], 'injury': [398, 443, 2129], 'response': [399, 673, 913, 942, 1312, 1334, 1531, 1635, 1674, 1969, 2496, 3040], 'mediators': [402], 'angiotensin': [405, 915, 944, 979, 994, 1015, 1029, 1070, 1154, 1165, 1314, 1336, 1359, 1363, 1393, 1490, 1501, 1576, 1637, 1676, 1728, 1761, 1789, 1902, 2591, 2648, 2807, 2845, 2928, 2970, 3042, 3322], 'induce': [407, 1792], 'production': [408, 468, 935, 984, 1020, 1972, 2042, 2360], 'that,': [414, 558], 'part,': [416], 'mediate': [417, 517], 'vasoconstriction,': [418], '"proliferative"': [423], 'phenotype.': [427, 2088], 'According': [428], 'paradigm,': [431], 'propose': [434], 'dysregulation': [440], 'response.': [444, 1156], 'Because': [445, 1287, 2128], 'critical': [455, 2919], 'part': [456], 'response,9': [459], 'understanding': [460, 1654, 2140], 'mechanism(s)': [462], 'injury-related': [464], 'become': [470], 'subject': [472], 'interest.': [475], 'Download': [476, 677], 'figureDownload': [477, 678], 'PowerPointFigure': [478, 679], '1.': [479], 'Paradigm': [480], 'demonstrating': [481], 'opposing': [482], 'species-mediated': [487], 'contrast': [490], 'oxide.': [495], 'NO': [496, 1955, 1971, 2014], 'tends': [497], 'promote': [499], 'quiescent': [500], 'flow': [505], 'arteries.': [508], 'mediated': [514], 'signals': [515, 1189], '"injury"-related': [518], 'occurrence': [526], 'disease.Among': [529], 'sources': [532, 4290], 'injury,': [539], 'NADPH': [540, 681, 688, 774, 871, 1065, 1753, 1846, 1937, 2075, 2099, 2123, 2144, 2321, 2492, 2640, 2709, 2764, 3031, 3062, 3748, 4038, 4064, 4207], 'oxidase': [541, 682, 689, 704, 796, 1066, 1754, 1847, 1938, 2100, 2322, 2493, 2539, 2550, 2641, 2669, 2869, 3032, 3063, 3749, 4039, 4208], 'perhaps': [543, 1678], 'best': [545, 1191], 'characterized.': [546], 'This': [547, 598, 1157, 1565, 1600, 1850, 1946], 'multicomponent': [548], 'enzyme': [549, 579, 613, 622, 663, 719, 1039, 1427], 'consists': [550], 'cytosolic': [552, 701], 'accessory': [553], 'proteins': [554, 813, 2366], '(Rac,': [555], 'p47phox,': [556, 800], 'p67phox)': [557], 'stimulation,': [560], 'associate': [561], 'membrane': [564, 703], 'catalytic': [565, 2399], 'subunits': [566, 705], '(Nox,': [567], 'p22phox)': [568], 'facilitate': [570], '2).10,11': [574], 'For': [575, 1658, 1982], 'many': [576, 642], 'thought': [581, 748], 'exist': [583, 635], 'isoform': [587, 760, 817, 869, 907, 1755, 1844], 'phagocytes': [590], 'its': [592, 885, 1978], 'function': [593, 3631], 'restricted': [594, 1883], 'antimicrobial': [596], 'action.': [597], 'changed': [600], 'drastically': [601], 'discovery': [604], 'multiple': [606], 'Nox': [607, 633, 694, 730, 759, 816, 832, 1857, 3873], 'isoforms': [608, 731, 1858, 1939, 2101], 'represent': [611, 2059], 'family': [614, 634, 664, 833, 2365, 2608], 'containing': [615], 'at': [616, 1926], 'least': [617], '5': [618], 'members.': [619], 'The': [620, 717, 998, 1102, 1362, 1431, 1967, 2665, 2762, 3176, 3455, 3518, 3566, 4288, 4454, 4476], 'phagocyte': [621, 2320], 'known': [625, 722, 734, 792, 1525, 1686, 1860, 2133], 'Nox2,12': [627], 'several': [629], 'members': [630, 834], '2),': [640], 'appearing': [643], 'be': [645, 750, 1192, 1224, 1554, 1607, 2135], 'upregulated': [646], 'setting': [649], 'atherosclerosis5': [651], 'injury.9,16': [654], 'Consistent': [655], 'observations,': [658], 'activity': [660, 818, 4069], 'atherosclerosis,': [669, 3907, 4006, 4616], 'hypertension,': [670, 1763, 3633, 4296], '2.': [680], '(Nox)': [683], 'vasculature.': [685], 'Top,': [686], 'neutrophil': [687, 718, 795, 2763], 'generalized': [691], 'all': [693], 'isoforms.': [695, 3148], 'Cellular': [696, 3385], 'stimulation': [697, 740], 'produces': [698], 'assembly': [699, 2870], 'generate': [707], 'often': [710, 1242], 'metabolized': [711], 'peroxide.': [716], 'Nox2': [724, 1597, 1880, 1909, 4577, 4594], 'subunit': [726, 4205], 'requirements': [727], 'other': [729, 815], 'certainty.': [736], 'neutrophils,': [738], 'involved': [741, 2968, 4389], 'invasion,': [743], 'whereas': [744, 1722, 1889, 1918], 'oxidases': [746, 775, 2076, 2124, 2145, 2742, 4065], 'activated': [751, 2926], 'agents': [753], 'Bottom,': [758], 'expression': [761, 1867, 1881, 2362, 4035], 'cells.Although': [765], 'there': [766], 'enthusiasm': [769], 'involvement': [772], 'pathogenesis': [778, 4483], 'disease,': [781, 2139, 3668], 'supportive': [785], 'evidence': [786, 1785], 'circumstantial.': [788], 'Although': [789], '(Nox2)': [797, 1756], 'requires': [798, 1434, 1901], 'p22phox,': [799], 'Rac1': [802], 'full': [804], 'activity,17': [805], 'our': [806, 1653], 'knowledge': [807, 863, 2155], 'concerning': [808], 'contribution': [810, 839, 2121], 'yet': [821], 'clear.': [822], 'consequence,': [825], 'little': [826], 'information': [827], 'exists': [828], 'individual': [831], 'their': [838, 1645], 'pathology.': [842, 889, 1032, 1657, 2127], 'Two': [843], 'important': [844, 1811, 2061, 2136], 'articles': [845], 'issue': [848, 1829], 'Circulation': [850, 4332], 'broken': [852], 'new': [853, 2160], 'ground': [854], 'begun': [857], 'bridge': [859], 'gap': [861], 'Nox1': [868, 882, 900, 922, 953, 969, 1009, 1026, 1055, 1082, 1141, 1281, 1285, 1309, 1388, 1406, 1486, 1715, 1890, 1922, 2055, 2804, 2966, 3090], 'oxidase.': [872, 2405, 2765], 'Dikalova': [873, 1001, 1048, 1262, 1480, 1616, 1708, 2773], 'colleagues18': [875, 1003, 1618], 'used': [876, 893], '"gain-of-function"': [878, 1258], 'strategy': [879, 1259], 'overexpress': [881, 899], 'determine': [884, 1305], 'implications': [886], 'particular,': [891], 'they': [892], 'elegant': [894], 'genetic': [895, 2052], 'techniques': [896], 'specifically': [898, 1004], 'where': [905, 2005], 'II.11': [916], 'They': [917], 'overexpression': [920, 954, 1080, 1428, 1446, 1457, 1487, 1716, 2805], 'basal': [928], 'increase': [929, 1095, 1365], 'without': [936], 'any': [937, 1442, 1561], 'overt': [938], 'pathology.18': [940], 'II': [945, 1155, 1166, 1337, 1577, 1638, 1790, 3043], 'infusion,': [946], 'animals': [948, 966], 'greatly': [956], 'exaggerated': [957], 'hypertension': [958, 1091, 1730, 2809], 'medial': [960, 1087, 1367, 1395, 1520, 1558, 1612, 1632, 1703, 1712, 1777, 1793], 'hypertrophy': [962, 1088, 1368, 1633, 1713, 1778, 1794, 2814], 'compared': [964, 1572, 1779], 'levels.18': [970], 'These': [971, 1275, 1343, 1380], 'consistent': [974, 1568, 1743], 'published': [976], 'observations': [977, 1570], 'II–induced': [980, 995, 1016, 1071, 1360, 1364, 1394, 1491, 1729, 1762, 2592, 2808, 2846], 'induces': [985, 1167], 'hypertrophy19': [989], 'hypertensive': [996, 1333, 1673], 'response.20': [997], 'work': [999, 1834], 'identifies': [1005], 'plausible': [1012], 'source': [1013, 1562], 'supports': [1022], 'II–mediated': [1030, 2971], 'Given': [1033, 2012], 'broad': [1035], 'efficacy': [1036], 'angiotensin-converting': [1038], 'inhibitors': [1040, 2893], 'ameliorate': [1042], 'disease,21': [1044], 'coworkers': [1050], 'would': [1051, 1190, 1639], 'support': [1052, 1610, 1642], 'speculation': [1053, 1947], 'contribute': [1057, 1357], 'general.Given': [1061], 'previous': [1062, 1746], 'required': [1068, 1177, 1209], 'hypertrophy,19': [1075], 'notable': [1078], 'alone': [1083], 'induced': [1085], 'mild': [1086], 'no': [1090, 1735, 1758], 'despite': [1092, 1375], 'demonstrable': [1094], 'signal.18': [1101], 'authors': [1103], 'explain': [1104], 'findings': [1106, 1344, 1413, 1741], 'noting': [1108], 'compensatory': [1109], 'upregulation': [1110, 1595, 3713, 4361], 'antioxidant': [1112, 1622], 'enzymes': [1113, 1958], 'catalase,': [1115], 'manganese': [1116], 'dismutase),': [1118], 'potentially': [1120], 'mitigated': [1121], 'influence': [1123], 'species.': [1127], 'One': [1128, 1418], 'must': [1129], 'consider,': [1131], 'alternative': [1134], 'interpretation': [1135], 'from': [1140, 1405, 1414, 1615, 1700], 'sufficient': [1144, 1608], 'recapitulate': [1146], 'entire': [1148], 'spectrum': [1149], 'view': [1158], 'coincides': [1159], 'vitro': [1162, 2552], 'species–dependent': [1170], '–independent': [1172], 'hypertrophy.22': [1182], 'Under': [1183], 'scenario,': [1185], 'species–mediated': [1188], 'viewed': [1193], 'permissive': [1196], 'exerting': [1198], 'modulatory': [1200, 1236], 'influences': [1201], 'rather': [1205], 'being': [1207], 'strictly': [1208], 'specific': [1211], 'responses.': [1213], 'regard,': [1216], 'role': [1218, 1237, 2079, 2142, 2490, 4477], 'could': [1223, 1553, 1606, 1809, 2043], 'likened': [1225], 'NO,': [1229, 1682, 1961], 'largely': [1235], 'counterbalances': [1243], '1).In': [1252], 'classic': [1254], 'complement': [1255], 'employed': [1260], 'coworkers,18': [1264], 'Matsuno': [1268, 1383, 1723, 2944], 'colleagues23': [1270], 'employs': [1271], '"loss-of-function"': [1273], 'approach.': [1274], 'investigators': [1276], 'created': [1277], 'mice': [1278, 1301, 1321, 1374, 1590, 1733, 1749, 2486], 'deficient': [1279, 1750], 'disrupting': [1283], 'gene.': [1286], 'gene': [1289, 4034, 4202], 'X': [1293, 3547, 3700], 'chromosome,': [1294], 'possible': [1297, 1419, 1452, 1509, 1541], 'male': [1300], 'Nox1−/Y)': [1303], 'effect': [1307, 1736, 4366, 4392], 'II.': [1315, 2649, 2929], 'Compared': [1316], 'wild-type': [1318, 1781], 'mice,': [1319], 'Nox1-null': [1320, 1373, 1589, 1732], 'exhibited': [1322], 'attenuation': [1323, 1768, 3558], 'after': [1338, 2745], '7': [1339], 'days': [1340], 'treatment.23': [1342], 'total': [1347], 'agreement': [1348], 'Nox1-derived': [1353, 1664], 'hypertension.18': [1361], 'blunted': [1371], 'reduced': [1377, 1727], 'blood': [1378, 1689, 1799, 2876], 'pressure.': [1379, 1690, 1800], 'colleagues': [1385, 1710], 'suggest': [1386], 'necessary': [1391], 'hypertrophy,': [1396, 1559], 'finding': [1398], 'contrasts': [1400], 'conclusions': [1403], 'derived': [1404], 'overexpressing': [1407], 'mice.18How': [1408], 'we': [1410, 2115], 'reconcile': [1411], '2': [1416, 1648, 2051, 3184], 'studies?': [1417], 'explanation': [1420], 'relates': [1421], 'different': [1424], 'strategies': [1425, 2161], 'employed:': [1426], 'versus': [1429], 'deletion.': [1430], 'former': [1432], 'approach': [1433], 'care': [1436], 'interpretation.': [1440], 'uses': [1445], 'protein,': [1449], 'extent': [1455], 'does': [1458], 'mimic': [1460], 'situation': [1462], 'normally': [1463], 'observed': [1464, 1499], 'nature,': [1466], 'potential': [1469], 'consequence': [1470], 'introducing': [1472], 'nonspecific': [1473], 'effects.': [1474], 'Focusing': [1475], 'colleagues,18': [1482], 'seems': [1484, 1931], 'afforded': [1488], 'far': [1496], 'exceeding': [1497], 'infusion': [1502], 'alone.': [1503], 'instance,': [1506], '"excess"': [1512], 'nonphysiological': [1513], 'additional': [1519], 'hypertrophy.': [1521, 1613, 1704, 2848, 2936], 'Indeed,': [1522], 'highly': [1537], 'dose': [1538], 'dependent.24': [1539], 'Another': [1540], 'reason': [1542], 'discrepancy': [1545], 'studies': [1547, 1649, 1661, 1694, 1825], 'responsible': [1555], 'will': [1563], 'suffice.': [1564], 'contention': [1566], 'animals,': [1575, 1707], 'still': [1578], '(albeit': [1582], 'blunted)': [1583], 'association': [1592], 'Nox4.23': [1599], 'Nox1-independent': [1601], 'Data': [1614], 'tempol': [1620], '(an': [1621], 'compound)': [1623], 'attenuated': [1624], 'signal': [1630, 1775, 2430, 2450], 'tend': [1640], 'viewpoint.Despite': [1644], 'differences,': [1646], 'add': [1650], 'collectively': [1651], 'example,': [1659, 1983], 'impact': [1670], 'II,18,23': [1677], 'through': [1679, 3557, 3875], 'scavenging': [1680], 'potent': [1684], 'vasodilator': [1685], 'regulate': [1688], 'addition,': [1692], 'effectively': [1696], 'separated': [1697], 'hemodynamic': [1698], 'saline-treated': [1706], 'hypertension,18': [1721], 'al': [1725], 'hypertrophy.23': [1738], 'Together,': [1739], 'report': [1747], 'another': [1752, 1962], 'defect': [1759], 'do': [1765], 'exhibit': [1766], 'significant': [1767, 1904], 'mice.25': [1782], 'Thus,': [1783], 'emerging': [1784], 'clearly': [1786], 'indicates': [1787], 'independent': [1795], 'If': [1801], 'extend': [1804], 'humans,': [1806], 'then': [1807], 'provide': [1810], 'insights': [1812], 'into': [1813], 'how': [1814], 'abnormalities': [1815], 'architecture': [1818], 'precede': [1820], 'hypertension.The': [1824], 'presented': [1826, 2057], 'Circulation18,23': [1831], 'Wang': [1836, 3015, 3302, 3699, 4384], 'colleagues25': [1838], 'differ': [1839, 1862], 'under': [1848], 'study.': [1849], 'trivial': [1854], 'point': [1855], 'respect': [1864], 'cell-specific': [1866], '2)': [1869], 'sites': [1872], 'localization.': [1874], 'endothelium': [1886], 'adventitia,25': [1888], 'expressed': [1892, 2169], 'periadventitial': [1898], 'fat18': [1899], 'upregulation.': [1905], 'cells,': [1908, 4045, 4405], 'predominantly': [1911], 'perinuclear': [1912], 'near': [1914], 'endoplasmic': [1916], 'reticulum,26': [1917], 'colocalizes': [1923], 'caveolin': [1925], 'plasma': [1928], 'membrane.27': [1929], 'likely': [1932], 'differences': [1935], 'among': [1936], 'reflect': [1940], 'distinct': [1941], 'functions': [1942], 'molecular': [1944, 4289], 'targets.': [1945], 'supported': [1949], 'literature': [1952], 'synthase': [1956, 3147], '(NOS)': [1957], 'freely': [1963], 'diffusible': [1964], 'vary': [1974], 'dramatically': [1975], 'depending': [1976], 'site': [1979, 2223], 'synthesis.': [1981], 'cardiac': [1985], 'myocytes': [1986], 'NOS3': [1987], 'localized': [1989], 'caveolae': [1991], 'regulates': [1993, 2007, 3138], 'L-type': [1994], 'Ca2+': [1995, 2010], 'channels.28': [1996], 'NOS1': [1999], 'resides': [2000], 'sarcoplasmic': [2003], 'reticulum,': [2004], 'ryanodine': [2008], 'receptor': [2009, 2272], 'release.28': [2011], 'share': [2022], 'similar': [2023], 'properties': [2025], 'al8),': [2030], 'surprising': [2034], 'site(s)': [2037], 'dictate': [2044], 'response(s).In': [2048], 'summary,': [2049], 'models': [2053, 2092, 2113], 'manipulation': [2056], 'here': [2058], 'milestone': [2062], 'research': [2064], 'disease.': [2070], 'clear': [2073], 'play': [2077], 'control': [2085], 'We': [2089], 'need': [2090], 'which': [2094], 'genes': [2096], 'various': [2098], 'overexpressed': [2104], 'deleted.': [2106], 'Only': [2107], 'advent': [2110], 'hope': [2116], 'test': [2118], 'precise': [2120], 'inflammation': [2131], 'processes': [2148], 'paramount': [2151], 'importance,': [2152], 'help': [2157], 'us': [2158], 'develop': [2159], 'treatment': [2164], 'cardiovascular': [2166], 'disease.The': [2167], 'opinions': [2168], 'article': [2172], 'necessarily': [2175], 'those': [2176], 'editors': [2179], 'American': [2183, 4455], 'Heart': [2184, 3635], 'Association.FootnotesCorrespondence': [2185], 'Keaney,': [2189], 'Jr,': [2190, 2464], 'MD,': [2191], 'MA,': [2207], '02118.': [2208], 'E-mail': [2209], '[email': [2210], 'protected]': [2211], 'References': [2212], '1': [2213], 'Goldstein': [2214], 'JL,': [2215], 'Ho': [2216], 'YK,': [2217], 'Basu': [2218], 'SK,': [2219], 'Brown': [2220], 'MS.': [2221, 2530], 'Binding': [2222], 'macrophages': [2225, 3240], 'mediates': [2227, 2590], 'uptake': [2228], 'degradation': [2230, 2259], 'acetylated': [2232, 2274], 'density': [2234, 2262, 2276], 'lipoprotein,': [2235], 'producing': [2236], 'massive': [2237], 'cholesterol': [2238], 'deposition.': [2239], 'Proc': [2240, 2278, 2500, 2650], 'Natl': [2241, 2279, 2501, 2651], 'Acad': [2242, 2280, 2502, 2652], 'Sci': [2243, 2281, 2503, 2653], 'U': [2244, 2282, 2504, 2654, 3450, 4158, 4608], 'S': [2245, 2283, 2505, 2655, 3311, 3492, 3995, 4060, 4385], 'A.': [2246, 2284, 2506, 2656], '1979;': [2247], '76:': [2248], '333–337.CrossrefMedlineGoogle': [2249], 'Scholar2': [2250], 'Henriksen': [2251], 'T,': [2252, 2376, 2378, 2382, 2692, 2887, 3196, 3256, 3486, 3928, 4238, 4244, 4246, 4469], 'Mahoney': [2253], 'EM,': [2254], 'Steinberg': [2255], 'D.': [2256], 'Enhanced': [2257], 'lipoprotein': [2263], 'previously': [2264], 'incubated': [2265], 'cultured': [2267, 3066], 'cells:': [2269, 2588], 'recognition': [2270], 'lipoproteins.': [2277], '1981;': [2285], '78:': [2286], '6499–6503.CrossrefMedlineGoogle': [2287], 'Scholar3': [2288], 'Stocker': [2289], 'R,': [2290, 2682, 2776, 3231, 3651, 4349, 4426, 4531, 4564], 'Keaney': [2291, 2441, 2462, 2888, 4108], 'JF': [2292, 2442, 2463, 2889], 'Jr.': [2293, 2443, 2890], 'Role': [2294, 2839, 2930, 3029, 4506], 'modifications': [2297], 'atherosclerosis.': [2299, 2369], 'Physiol': [2300], 'Rev.': [2301], '2004;': [2302, 2407, 2507], '84:': [2303], '1381–1478.CrossrefMedlineGoogle': [2304], 'Scholar4': [2305], 'Jones': [2306, 2316, 3931], 'SA,': [2307], "O'Donnell": [2308], 'VB,': [2309], 'Wood': [2310], 'JD,': [2311, 2352, 2354, 2578, 2735, 2759, 2801, 3083], 'Broughton': [2312], 'JP,': [2313], 'Hughes': [2314], 'EJ,': [2315], 'OT.': [2317], 'Expression': [2318, 3940, 4062, 4442], 'components': [2323], 'human': [2325, 2368, 2698, 4041, 4071, 4401], 'cells.': [2327, 3068, 3097], 'Am': [2328], 'J': [2329, 2556, 2711, 2937, 3069, 3966, 4109, 4474], 'Physiol.': [2330], '1996;': [2331], '271:': [2332], 'H1626–H1634.MedlineGoogle': [2333], 'Scholar5': [2334], 'Sorescu': [2335, 2345, 2565, 2722, 2985], 'D,': [2336, 2338, 2566, 2723, 2793, 2951, 2986, 3814, 3856, 3895, 3932, 4143], 'Weiss': [2337, 2792], 'Lassegue': [2339, 2563, 2720, 2777], 'B,': [2340, 2468, 2564, 2721, 2778, 3125, 3166, 3402, 3609, 3741, 4566], 'Clempus': [2341, 2775, 3078], 'RE,': [2342, 3079], 'Szocs': [2343, 2567, 2718], 'K,': [2344, 2418, 2438, 2568, 2686, 2719, 2945, 2949, 2959, 3194, 3200, 3490, 3862, 4100, 4149, 4234], 'GP,': [2346], 'Valppu': [2347, 2726], 'L,': [2348, 2470, 2727, 3350, 3392, 3615, 3926, 4139, 4345, 4347, 4562], 'Quinn': [2349, 2632, 2732, 2860, 3023, 3080], 'MT,': [2350, 2733, 2861, 3024, 3081], 'Lambeth': [2351, 2577, 2605, 2734, 2758, 2800, 3082], 'Vega': [2353], 'Taylor': [2355, 2794, 2835], 'WR,': [2356, 2795, 2836], 'Griendling': [2357, 2579, 2736, 2802, 2837, 2911, 2995, 3084], 'KK.': [2358, 2580, 2737, 2803, 2838, 2912, 2996, 3085], 'Superoxide': [2359], 'nox': [2364], 'Circulation.': [2370, 2406, 2818, 2900, 2978], '2002;': [2371, 2618, 2677, 2752, 2769, 3011, 3072, 3150], '105:': [2372], '1429–1435.LinkGoogle': [2373], 'Scholar6': [2374], 'Ago': [2375], 'Kitazono': [2377], 'Ooboshi': [2379], 'H,': [2380, 2392, 2694, 2947, 2963, 3198, 3305, 3346, 3354, 3396, 3404, 3406, 3830, 3924, 4017, 4230, 4240, 4242, 4416], 'Iyama': [2381], 'Han': [2383, 3345], 'YH,': [2384], 'Takada': [2385], 'J,': [2386, 2514, 2625, 2782, 3225, 3535, 3698, 3727, 3961, 4019, 4021, 4094, 4527], 'Wakisaka': [2387], 'M,': [2388, 2412, 2472, 2572, 2688, 2690, 2826, 2828, 2906, 2910, 2953, 2955, 2961, 2990, 2992, 3192, 3229, 3358, 3448, 3611, 3733, 3735, 4145, 4182, 4570], 'Ibayashi': [2389], 'S,': [2390, 2784, 2957, 3018, 3482, 3488, 3613, 3920, 4096, 4098, 4232, 4424], 'Utsumi': [2391], 'Iida': [2393], 'M.': [2394], 'Nox4': [2395, 3092], 'major': [2398], 'component': [2400, 2920], 'NAD(P)H': [2404, 2538, 2741, 2868], '109:': [2408], '227–233.LinkGoogle': [2409], 'Scholar7': [2410], 'Yu': [2413, 3925], 'ZX,': [2414], 'Ferrans': [2415], 'VJ,': [2416], 'Irani': [2417], 'Finkel': [2419], 'T.': [2420], 'Requirement': [2421], 'transduction.': [2431, 2451], 'Science.': [2432], '1995;': [2433], '270:': [2434], '296–299.CrossrefMedlineGoogle': [2435], 'Scholar8': [2436], 'Thomas': [2439, 4097], 'SR,': [2440], 'Beyond': [2444], 'oxidation:': [2446], 'ROS': [2447], 'Radic': [2453], 'Biol': [2454, 2557, 2712, 2938, 3070], 'Med.': [2455], '2003;': [2456, 2714, 3102], '35:': [2457], '117–132.CrossrefMedlineGoogle': [2458], 'Scholar9': [2459], 'Z,': [2461, 2520, 3930, 4529], 'Schulz': [2465, 4091], 'E,': [2466, 3164, 4092, 4281], 'Levison': [2467], 'Shan': [2469], 'Sakuma': [2471], 'Zhang': [2473, 2573, 3310, 3923, 4381, 4415, 4419, 4425], 'X,': [2474, 3394, 3539, 3543], 'Shi': [2475, 3359], 'C,': [2476, 2512, 2522, 2528, 3352, 3545, 3619, 3621, 3737, 3739, 3858, 3897, 4023, 4153], 'Hazen': [2477], 'SL,': [2478, 2576], 'Simon': [2479], 'DI.': [2480], 'Decreased': [2481], 'neointimal': [2482], 'formation': [2483, 2594], 'Nox2-deficient': [2485], 'reveals': [2487], 'direct': [2489], '101:': [2508], '13014–13019.CrossrefMedlineGoogle': [2509], 'Scholar10': [2510], 'Patterson': [2511], 'Ruef': [2513], 'Madamanchi': [2515], 'NR,': [2516], 'Barry-Lane': [2517], 'P,': [2518, 2988, 3348, 3541, 3771, 4104, 4277, 4341, 4430, 4467], 'Hu': [2519], 'Horaist': [2521], 'Ballinger': [2523], 'CA,': [2524, 3121], 'Brasier': [2525], 'AR,': [2526], 'Bode': [2527], 'Runge': [2529], 'Stimulation': [2531], 'thrombin.': [2541], 'Evidence': [2542, 4323], 'p47(phox)': [2544], 'participate': [2546, 2704], 'forming': [2548], 'vivo.': [2555], 'Chem.': [2558, 2713, 2939, 3071], '1999;': [2559], '274:': [2560], '19814–19822.CrossrefMedlineGoogle': [2561], 'Scholar11': [2562], 'Yin': [2569, 2829, 2993], 'Q,': [2570, 2830, 2994, 3356], 'Akers': [2571, 2827, 2909, 2991], 'Y,': [2574, 3022, 3307, 3309, 3408, 3476, 3478, 3480, 3533, 3922, 3990, 4236, 4418, 4422, 4428], 'Grant': [2575], 'Novel': [2581, 2697, 2864], 'gp91(phox)': [2582], 'homologues': [2583, 2699], 'nox1': [2589], 'redox-sensitive': [2596, 2923], 'pathways.': [2598], 'Circ': [2599, 2880, 3046], 'Res.': [2600, 2881, 3047], '2001;': [2601, 2882, 2901, 3048], '88:': [2602, 3049], '888–894.CrossrefMedlineGoogle': [2603], 'Scholar12': [2604], 'JD.': [2606], 'Nox/Duox': [2607], 'nicotinamide': [2610], 'adenine': [2611], 'dinucleotide': [2612], '(phosphate)': [2613], 'oxidases.': [2614, 2710], 'Curr': [2615], 'Opin': [2616], 'Hematol.': [2617], '9:': [2619], '11–17.CrossrefMedlineGoogle': [2620], 'Scholar13': [2621], 'Pagano': [2622, 2663, 2862], 'PJ,': [2623], 'Clark': [2624, 2628], 'Cifuentes-Pagano': [2626], 'ME,': [2627, 2857], 'SM,': [2629], 'Callis': [2630], 'GM,': [2631], 'MT.': [2633], 'Localization': [2634], 'constitutively': [2637], 'active,': [2638], 'phagocyte-like': [2639], 'rabbit': [2643], 'aortic': [2644, 3243, 3325, 3435, 4042, 4402], 'adventitia:': [2645, 2667], 'enhancement': [2646], '1997;': [2657], '94:': [2658], '14483–14488.CrossrefMedlineGoogle': [2659], 'Scholar14': [2660], 'Rey': [2661, 2854], 'FE,': [2662, 2855], 'PJ.': [2664, 2863], 'fibroblast': [2668], 'function.': [2672], 'Arterioscler': [2673, 2748, 3098], 'Thromb': [2674, 2749, 3099], 'Vasc': [2675, 2750, 3100], 'Biol.': [2676, 2751, 3101], '22:': [2678, 2753], '1962–1971.LinkGoogle': [2679], 'Scholar15': [2680], 'Takeya': [2681], 'Ueno': [2683], 'N,': [2684, 3400, 3832], 'Kami': [2685], 'Taura': [2687], 'Kohjima': [2689], 'Izaki': [2691], 'Nunoi': [2693], 'Sumimoto': [2695], 'H.': [2696], 'p47phox': [2701], 'p67phox': [2703], 'activation': [2706, 3421], 'superoxide-producing': [2708], '278:': [2715], '25234–25246.CrossrefMedlineGoogle': [2716], 'Scholar16': [2717], 'Hilenski': [2724, 3076], 'LL,': [2725, 3077], 'Couse': [2728], 'TL,': [2729], 'Wilcox': [2730], 'JN,': [2731], 'Upregulation': [2738], 'Nox-based': [2740], 'restenosis': [2744], 'carotid': [2746], '21–27.CrossrefMedlineGoogle': [2754], 'Scholar17': [2755], 'Babior': [2756], 'BM,': [2757], 'Nauseef': [2760], 'W.': [2761], 'Arch': [2766], 'Biochem': [2767], 'Biophys.': [2768], '397:': [2770], '342–344.CrossrefMedlineGoogle': [2771], 'Scholar18': [2772], 'A,': [2774, 2787, 2789, 2832, 2859, 3202, 3258, 3729, 3731, 3893, 4102, 4137, 4147, 4184, 4307, 4311, 4313, 4568], 'Cheng': [2779, 4027], 'G,': [2780, 3649, 4141, 4279, 4315, 4434], 'McCoy': [2781], 'Dikalov': [2783], 'San': [2785], 'Martin': [2786], 'Lyle': [2788], 'Weber': [2790], 'DS,': [2791], 'Schmidt': [2796], 'HHW,': [2797], 'Owens': [2798], 'GK,': [2799], 'potentiates': [2806], 'transgenic': [2816], 'mice.': [2817, 2879, 2977, 3045], '2005;': [2819, 2979], '112:': [2820, 2980], '2668–2676.LinkGoogle': [2821], 'Scholar19': [2822], 'Zafari': [2823], 'AM,': [2824], 'Ushio-Fukai': [2825, 2905, 2989], 'Shah': [2831, 3054], 'Harrison': [2833, 3108], 'DG,': [2834, 3020], 'NADH/NADPH': [2841], 'oxidase–derived': [2842], 'Hypertension.': [2849], '1998;': [2850, 2940], '32:': [2851], '488–495.CrossrefMedlineGoogle': [2852], 'Scholar20': [2853], 'Cifuentes': [2856], 'Kiarash': [2858], 'competitive': [2865], 'inhibitor': [2866], 'attenuates': [2871], 'O(2)(−)': [2873], 'systolic': [2875], 'pressure': [2877], '89:': [2883], '408–414.CrossrefMedlineGoogle': [2884], 'Scholar21': [2885], 'Munzel': [2886], 'Are': [2891], 'ACE': [2892], '"magic': [2895], 'bullet"': [2896], 'against': [2897, 3318], 'stress?': [2899], '104:': [2902], '1571–1574.CrossrefMedlineGoogle': [2903], 'Scholar22': [2904], 'Alexander': [2907], 'RW,': [2908, 3109], 'p38': [2913, 3331], 'Mitogen-activated': [2914], 'protein': [2915], 'kinase': [2916], 'pathways': [2925], '273:': [2941], '15022–15029.CrossrefMedlineGoogle': [2942], 'Scholar23': [2943], 'Yamada': [2946], 'Iwata': [2948], 'Jin': [2950], 'Katsuyama': [2952], 'Matsuki': [2954], 'Takai': [2956], 'Yamanishi': [2958], 'Miyazaki': [2960], 'Matsubara': [2962], 'Yabe-Nishimura': [2964], 'C.': [2965], 'hypertension:': [2972], 'nox1-deficient': [2976], '2677–2685.LinkGoogle': [2981], 'Scholar24': [2982], 'Deshpande': [2983], 'NN,': [2984], 'Seshiah': [2987], 'Mechanism': [2997], 'peroxide-induced': [3000], 'cycle': [3002], 'arrest': [3003], 'Antioxid': [3008], 'Redox': [3009, 4163], 'Signal.': [3010], '4:': [3012], '845–854.CrossrefMedlineGoogle': [3013], 'Scholar25': [3014], 'HD,': [3016], 'Xu': [3017, 3534, 3929, 4526], 'Johns': [3019], 'Du': [3021], 'Cayatte': [3025], 'AJ,': [3026], 'Cohen': [3027], 'RA.': [3028], 'hypertrophic': [3036], '947–953.CrossrefMedlineGoogle': [3050], 'Scholar26': [3051], 'Li': [3052, 3770], 'JM,': [3053], 'AM.': [3055], 'Intracellular': [3056], 'localization': [3057], 'preassembly': [3059], 'complex': [3064], '277:': [3073], '19952–19960.CrossrefMedlineGoogle': [3074], 'Scholar27': [3075], 'Distinct': [3086], 'subcellular': [3087], 'localizations': [3088], '24:': [3103], '677–683.MedlineGoogle': [3104], 'Scholar28': [3105], 'Barouch': [3106], 'LA,': [3107], 'Skaf': [3110], 'MW,': [3111], 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4013, 4053, 4088, 4133, 4176, 4226, 4303, 4337, 4378, 4412, 4463, 4497, 4555, 4604, 4622], 'date:': [3222, 3253, 3300, 3343, 3445, 3473, 3530, 3576, 3590, 3606, 3642, 3646, 3676, 3724, 3768, 3811, 3890, 3917, 3958, 3987, 4014, 4054, 4089, 4134, 4177, 4227, 4304, 4338, 4379, 4413, 4464, 4498, 4556, 4605, 4623], '1-May-2020.': [3223], 'Raffort': [3224], 'Lareyre': [3226], 'F,': [3227, 3303, 3398, 3484, 4151, 4432, 4558], 'Clément': [3228], 'Hassen-Khodja': [3230], 'Chinetti': [3232], 'G': [3233, 3816, 3899], 'Mallat': [3235], 'Z': [3236, 3703], '(2017)': [3237], 'Monocytes': [3238], 'abdominal': [3242, 3324, 3434], 'aneurysm,': [3244, 3436], 'Nature': [3245], 'Reviews': [3246], 'Cardiology,': [3247, 4492], '10.1038/nrcardio.2017.52,': [3248], '14:8,': [3249], '(457-471),': [3250], '1-Aug-2017.': [3254], 'Manuwa': [3255], 'Akinmoladun': [3257], 'Crown': [3259], 'O,': [3260], 'Komolafe': [3261], 'K': [3262, 4248, 4504], 'Olaleye': [3264], '(2015)': [3266, 3364], 'Toxicological': [3267], 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[3357], 'L': [3363, 3550, 4057], 'Flaxseed': [3365], 'Oil': [3366], 'Containing': [3367], 'α': [3368], '-Linolenic': [3369], 'Acid': [3370], 'Ester': [3371], 'Plant': [3373], 'Sterol': [3374], 'Improved': [3375], 'Atherosclerosis': [3376], 'ApoE': [3378], 'Deficient': [3379], 'Mice': [3380], ',': [3381], 'Oxidative': [3382, 3579, 3684, 3689, 4264, 4326, 4356, 4582, 4613], 'Longevity,': [3386], '10.1155/2015/958217,': [3387], '2015,': [3388], '(1-17),': [3389], '.': [3390, 3854, 4275, 4525], 'WANG': [3391, 3401, 3409], 'CHENG': [3393], 'LI': [3395], 'QIU': [3397], 'YANG': [3399], 'LU': [3403], 'WU': [3405], 'SHEN': [3407], 'JING': [3412], 'H': [3413, 3934, 4251, 4382], '(2013)(2013)': [3414], 'Quercetin': [3415], 'reduces': [3416, 3553], 'inhibits': [3420], 'c-Jun': [3423], 'N-terminal': [3424], 'kinase/activator': [3425], 'protein-1': [3426], 'experimental': [3430], 'mouse': [3431], 'model': [3432], 'Molecular': [3437, 3910], 'Reports,': [3439], '10.3892/mmr.2013.1846,': [3440], '9:2,': [3441], '(435-442),': [3442], '1-Feb-2014.': [3446], 'Demir': [3447], 'Uyan': [3449], 'Melek': [3452], '(2012)': [3454, 3551, 3578, 3592, 3657], 'Vitamin': [3458], 'Deficiency': [3460], 'Atrial': [3462, 4166], 'Fibrillation,': [3463], 'Clinical': [3464, 3521], 'Applied': [3466], 'Thrombosis/Hemostasis,': [3467], '10.1177/1076029612453762,': [3468], '20:1,': [3469], '(98-103),': [3470], '1-Jan-2014.': [3474], 'Ohta': [3475], 'Kawano': [3477], 'Iwashima': [3479], 'Hayashi': [3481], 'Yoshihara': [3483], 'Matayoshi': [3485], 'Takiuchi': [3487], 'Kamide': [3489], 'Nakamura': [3491, 3989], 'Horio': [3494], 'T': [3495, 3623, 4028, 4106], '(2013)': [3496], 'Control': [3497], 'Home': [3499], 'Blood': [3500, 4297], 'Pressure': [3501], 'Amlodipine-': [3504], 'Losartan-Based': [3506], 'Regimen': [3507], 'Progression': [3509], 'Carotid': [3511, 4255], 'Artery': [3512], 'Intima-media': [3513], 'Thickness': [3514, 4257], 'Hypertensive': [3516], 'Patients:': [3517], 'HOSP': [3519], 'Substudy,': [3520], 'Experimental': [3523, 4168], 'Hypertension,': [3524, 3718, 4269], '10.3109/10641963.2013.780074,': [3525], '35:4,': [3526], '(279-284),': [3527], '1-Jul-2013.': [3531], 'Tang': [3532], 'Qu': [3536], 'Peng': [3538], 'Xin': [3540], 'Yang': [3542, 3772], 'Ying': [3544], 'Sun': [3546, 3702], 'Hao': [3549], 'Resveratrol': [3552], 'senescence': [3556], 'SIRT1/NADPH': [3563], 'oxidase-dependent': [3564], 'mechanisms,': [3565], 'Journal': [3567, 3716, 3802, 4219, 4369, 4456, 4490], 'Nutritional': [3569], 'Biochemistry,': [3570], '10.1016/j.jnutbio.2011.08.008,': [3571], '23:11,': [3572], '(1410-1416),': [3573], '1-Nov-2012.': [3577], 'Metabolic': [3581, 3597, 4120], 'Syndrome': [3582, 3598], 'Disease,': [3585, 3601, 3981], '10.1002/9781118480045.ch6,': [3586], '(120-138),': [3587], '29-Aug-2012.': [3591, 3607], 'Skeletal': [3593], 'Muscle': [3594], 'Exercise': [3596], '10.1002/9781118480045.ch12,': [3602], '(303-346),': [3603], 'Simic': [3608], 'Hermann': [3610], 'Shaw': [3612], 'Bigler': [3614], 'Stalder': [3616], 'U,': [3617, 3860], 'Dörries': [3618], 'Besler': [3620], 'Lüscher': [3622], 'Ruschitzka': [3625], 'F': [3626, 3743, 3867, 4354], '(2011)': [3627, 3683, 3704, 3747, 3777], 'Torcetrapib': [3628], 'impairs': [3629], 'European': [3634], 'Journal,': [3636], '10.1093/eurheartj/ehr348,': [3637], '33:13,': [3638], '(1615-1624),': [3639], '1-Jul-2012.,': [3643], '1-Jul-2012.': [3647], 'Ouma': [3648], 'Jonas': [3650], 'Usman': [3652], 'Mohler': [3655], 'E': [3656, 4501], 'Targets': [3658], 'delivery': [3660], 'methods': [3661], 'therapeutic': [3663], 'angiogenesis': [3664], 'peripheral': [3666], 'artery': [3667, 4073], '10.1177/1358863X12438270,': [3671], '17:3,': [3672], '(174-192),': [3673], '1-Jun-2012.': [3677], 'Andrades': [3678], 'Lorenzi': [3681], 'R': [3682, 4351], 'Diseases': [3688], 'Vertebrates': [3692], 'Invertebrates,': [3694], '10.1002/9781118148143.ch11,': [3695], '(153-166)': [3696], 'Dammanahalli': [3697], 'Genetic': [3705], 'interleukin-10': [3706], 'deficiency': [3707], 'causes': [3708], 'remodeling': [3710], 'via': [3711], 'Nox1,': [3715], '10.1097/HJH.0b013e32834b22a0,': [3719], '29:11,': [3720, 4050], '(2116-2125),': [3721], '1-Nov-2011.': [3725, 3769], 'Piérola': [3726], 'Alemany': [3728], 'Yañez': [3730], 'de-la-Peña': [3732], 'Sánchez-de-la-Torre': [3734], 'Esquinas': [3736], 'Pérez-Gutierrez': [3738], 'Burguera': [3740], 'Barbé': [3742], 'Barceló': [3745], 'p22phox': [3750, 4204], 'polymorphisms': [3751, 4199], 'patients': [3756, 4363], 'obstructive': [3758], 'sleep': [3759], 'apnoea,': [3760], 'Respiratory': [3761], '10.1016/j.rmed.2011.08.006,': [3763], '105:11,': [3764], '(1748-1754),': [3765], 'Xuezhikang,': [3778], 'Extract': [3779], 'Red': [3781], 'Yeast': [3782], 'Rice,': [3783], 'Inhibited': [3784], 'Tissue': [3785], 'Factor': [3786], 'Hypercoagulable': [3788], 'State': [3789], 'Through': [3790], 'Suppressing': [3791], 'Nicotinamide': [3792], 'Adenine': [3793], 'Dinucleotide': [3794], 'Phosphate': [3795], 'Oxidase': [3796, 4542], 'Extracellular': [3798], 'Signal-regulated': [3799], 'Kinase': [3800], 'Activation,': [3801], 'Pharmacology,': [3805, 4407], '10.1097/FJC.0b013e3182244a2d,': [3806], '58:3,': [3807], '(307-318),': [3808], '1-Sep-2011.': [3812], 'Grassi': [3813], 'Desideri': [3815], 'Ferri': [3818], 'C': [3819, 3902, 4025], '(2010)': [3820, 3838], 'Flavonoids:': [3821], 'Antioxidants': [3822], 'Atherosclerosis,': [3824], 'Nutrients,': [3825], '10.3390/nu2080889,': [3826], '2:8,': [3827], '(889-902)': [3828], 'Vasanthi': [3829], 'Kartal-Özer': [3831], 'Azzi': [3833], 'Das': [3836], 'Dietary': [3839, 3846], 'Supplements,': [3840], 'Cholesterol': [3841], 'Disease': [3844, 3850], 'Modern': [3845], 'Fat': [3847], 'Intakes': [3848], 'Promotion,': [3851], '10.1007/978-1-60327-571-2_16,': [3852], '(227-247),': [3853], 'Richard': [3855], 'Wolf': [3857], 'Barbe': [3859], 'Kefi': [3861], 'Bausero': [3863], 'P': [3864, 4317, 4572, 4575], 'Visioli': [3866], '(2009)': [3868, 3903, 3938, 3967, 4287], 'Docosahexaenoic': [3869], 'acid': [3870, 3999, 4031], 'down-regulates': [3871], '4': [3874], 'sPLA2': [3877], 'signalling': [3878], 'pathway,': [3879], 'Biochemical': [3880, 4406], 'Biophysical': [3882], 'Research': [3883], 'Communications,': [3884], '10.1016/j.bbrc.2009.09.013,': [3885], '389:3,': [3886], '(516-522),': [3887], '1-Nov-2009.': [3891], 'Kampoli': [3892], 'Tousoulis': [3894], 'Antoniades': [3896], 'Siasos': [3898], 'Stefanadis': [3901], 'Biomarkers': [3904], 'Trends': [3908], '10.1016/j.molmed.2009.06.001,': [3912], '15:7,': [3913], '(323-332),': [3914], '1-Jul-2009.': [3918], 'Dai': [3919, 4423], 'He': [3921, 4421], 'Wan': [3927], 'Min': [3936, 3962, 4438], 'Endothelial-Specific': [3939, 4441], 'Mitochondrial': [3942, 4160, 4444], 'Thioredoxin': [3943, 4445], 'Promotes': [3944], 'Ischemia-Mediated': [3945], 'Arteriogenesis': [3946], 'Angiogenesis,': [3948], 'Arteriosclerosis,': [3949, 4547, 4596], 'Thrombosis,': [3950, 4548, 4597], 'Biology,': [3953, 4551, 4600], '29:4,': [3954], '(495-502),': [3955], '1-Apr-2009.': [3959], 'Pober': [3960], 'Bradley': [3965], 'Mechanisms': [3968, 3979], 'Endothelial': [3970, 4325, 4447, 4540], 'Dysfunction,': [3971, 4127], 'Injury,': [3972], 'Death,': [3974], 'Annual': [3975], 'Review': [3976], 'Pathology:': [3978], '10.1146/annurev.pathol.4.110807.092155,': [3982], '4:1,': [3983], '(71-95),': [3984], '1-Feb-2009.': [3988], 'Flintoff-Dye': [3991], 'N': [3992], 'Omaye': [3994], '(2008)': [3996, 4029, 4061, 4110, 4159, 4192, 4252], 'Conjugated': [3997], 'linoleic': [3998], 'modulation': [4000], 'risk': [4002, 4211], 'Nutrition': [4007], '&': [4008], 'Metabolism,': [4009], '10.1186/1743-7075-5-22,': [4010], '5:1,': [4011], '1-Dec-2008.': [4015], 'Chao': [4016], 'Lin': [4020], 'Wu': [4024], 'Uric': [4030], 'stimulates': [4032], 'endothelin-1': [4033], 'Acta': [4046], 'Pharmacologica': [4047], 'Sinica,': [4048], '10.1111/j.1745-7254.2008.00877.x,': [4049], '(1301-1312),': [4051], '1-Nov-2008.': [4055], 'Yoshida': [4056], 'Tsunawaki': [4059], 'enhanced': [4067], 'H2O2-generating': [4068], 'coronary': [4072], 'upon': [4076], 'induction': [4077], 'tumor': [4079], 'necrosis': [4080], 'factor-α,': [4081], 'International': [4082, 4489], 'Immunopharmacology,': [4083], '10.1016/j.intimp.2008.05.004,': [4084], '8:10,': [4085], '(1377-1385),': [4086], '1-Oct-2008.': [4090], 'Dopheide': [4093], 'Schuhmacher': [4095], 'Daiber': [4101], 'Wenzel': [4103], 'Münzel': [4105], 'Suppression': [4111], 'Pathway': [4115], 'Induction': [4117], 'Response': [4122], 'Prevents': [4123], 'Injury': [4125], 'Circulation,': [4128, 4522], '10.1161/CIRCULATIONAHA.108.784289,': [4129], '118:13,': [4130], '(1347-1357),': [4131], '23-Sep-2008.': [4135], 'Bukowska': [4136], 'Schild': [4138], 'Keilhoff': [4140], 'Hirte': [4142], 'Neumann': [4144, 4148], 'Gardemann': [4146], 'Röhl': [4150], 'Huth': [4152], 'Goette': [4154], 'Lendeckel': [4157], 'Dysfunction': [4161], 'Signaling': [4164], 'Tachyarrhythmia,': [4167], 'Biology': [4169], '10.3181/0706-RM-155,': [4172], '233:5,': [4173], '(558-574),': [4174], '1-May-2008.': [4178, 4228], 'Ivanov': [4179], 'V,': [4180, 4343, 4560], 'Solodilova': [4181], 'Polonikov': [4183], 'Khoroshaya': [4185], 'Kozhuhov': [4187], 'Panfilov': [4190], 'V': [4191], 'Association': [4193], 'analysis': [4194], 'C242T': [4196], 'A640G': [4198], 'bronchial': [4213], 'asthma:': [4214], 'pilot': [4216], 'study,': [4217], 'Russian': [4218], 'Genetics,': [4221], '10.1134/S102279540805013X,': [4222], '44:5,': [4223], '(601-608),': [4224], 'ONO': [4229], 'MINATOGUCHI': [4231], 'WATANABE': [4233], 'YAMADA': [4235], 'MIZUKUSA': [4237], 'KAWASAKI': [4239], 'TAKAHASHI': [4241], 'UNO': [4243], 'TSUKAMOTO': [4245], 'HIEI': [4247], 'FUJIWARA': [4250], 'Candesartan': [4253], 'Decreases': [4254], 'Intima-Media': [4256], 'Enhancing': [4259], 'Oxide': [4261], 'Decreasing': [4263], 'Patients': [4267, 4591], 'Hypertension': [4270, 4515], 'Research,': [4271, 4333], '10.1291/hypres.31.271,': [4272], '31:2,': [4273], '(271-279),': [4274], 'Puddu': [4276, 4278], 'Cravero': [4280], 'Rosati': [4282], 'Muscari': [4285], 'Pressure,': [4298], '10.1080/08037050802029954,': [4299], '17:2,': [4300], '(70-77),': [4301], '1-Jan-2008.': [4305], 'Donato': [4306], 'Eskurza': [4308], 'Silver': [4310], 'Levy': [4312], 'Pierce': [4314], 'Gates': [4316], 'Seals': [4319], '(2007)': [4321, 4355, 4386, 4440, 4475, 4505], 'Direct': [4322], 'Aging': [4329], 'Humans,': [4331], '100:11,': [4334], '(1659-1666),': [4335], '8-Jun-2007.': [4339], 'PIGNATELLI': [4340], 'SANGUIGNI': [4342], 'LENTI': [4344], 'LOFFREDO': [4346], 'CARNEVALE': [4348], 'SORGE': [4350], 'VIOLI': [4353], 'stress-mediated': [4357], 'CD40': [4359], 'ligand': [4360], 'hypercholesterolemia:': [4365], 'atorvastatin,': [4368], 'Thrombosis': [4371], 'Haemostasis,': [4373], '10.1111/j.1538-7836.2007.02533.x,': [4374], '5:6,': [4375], '(1170-1178),': [4376], '1-Jun-2007.': [4380], 'Nrf2': [4387], 'tanshinone': [4394], 'IIA': [4395], 'redox': [4398], 'status': [4399], '10.1016/j.bcp.2007.01.004,': [4408], '73:9,': [4409], '(1358-1366),': [4410], '1-May-2007.': [4414], 'Bernatchez': [4429], 'Giordano': [4431], 'Shadel': [4433], 'Sessa': [4435], 'Improves': [4446], 'Cell': [4448], 'Function': [4449], 'Reduces': [4451], 'Atherosclerotic': [4452], 'Lesions,': [4453], 'Pathology,': [4458], '10.2353/ajpath.2007.060960,': [4459], '170:3,': [4460], '(1108-1120),': [4461], '1-Mar-2007.': [4465], 'Korantzopoulos': [4466], 'Kolettis': [4468], 'Galaris': [4470], 'Goudevenos': [4473], 'perpetuation': [4485], 'atrial': [4487], 'fibrillation,': [4488], '10.1016/j.ijcard.2006.04.026,': [4493], '115:2,': [4494], '(135-143),': [4495], '1-Feb-2007.': [4499], 'Nozik-Grayck': [4500], 'Stenmark': [4503], 'Reactive': [4508], 'Oxygen': [4509], 'Species': [4510], 'Chronic': [4512], 'Hypoxia-Induced': [4513], 'Pulmonary': [4514], 'Remodeling': [4518], 'Hypoxia': [4519], '10.1007/978-0-387-75434-5_8,': [4523], 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