Title: Anaplastic carcinoma of the thyroid.A review of 84 cases of spindle and giant cell carcinoma of the thyroid
Abstract: CancerVolume 41, Issue 6 p. 2267-2275 ArticleFree Access Anaplastic carcinoma of the thyroid. A review of 84 cases of spindle and giant cell carcinoma of the thyroid Keith A. Aldinger MD, Keith A. Aldinger MD Section of Endocrinology, Department of Medicine, and Department of Pathology, The University of Texas System Cancer Center M. D. Anderson Hospital and Tumor Institute, Houston, TexasSearch for more papers by this authorNaguib A. Samaan MD, PhD, FACP, FRCP, Corresponding Author Naguib A. Samaan MD, PhD, FACP, FRCP Section of Endocrinology, Department of Medicine, and Department of Pathology, The University of Texas System Cancer Center M. D. Anderson Hospital and Tumor Institute, Houston, TexasChief, Section of Endocrinology, M. D. Anderson Hospital and Tumor Institute, 6723 Bertner Avenue, Houston, TX 77030===Search for more papers by this authorMichael Ibanez MD, FACP, Michael Ibanez MD, FACP Section of Endocrinology, Department of Medicine, and Department of Pathology, The University of Texas System Cancer Center M. D. Anderson Hospital and Tumor Institute, Houston, TexasSearch for more papers by this authorC. Stratton Hill Jr. MD, C. Stratton Hill Jr. MD Section of Endocrinology, Department of Medicine, and Department of Pathology, The University of Texas System Cancer Center M. D. Anderson Hospital and Tumor Institute, Houston, TexasSearch for more papers by this author Keith A. Aldinger MD, Keith A. Aldinger MD Section of Endocrinology, Department of Medicine, and Department of Pathology, The University of Texas System Cancer Center M. D. Anderson Hospital and Tumor Institute, Houston, TexasSearch for more papers by this authorNaguib A. Samaan MD, PhD, FACP, FRCP, Corresponding Author Naguib A. Samaan MD, PhD, FACP, FRCP Section of Endocrinology, Department of Medicine, and Department of Pathology, The University of Texas System Cancer Center M. D. Anderson Hospital and Tumor Institute, Houston, TexasChief, Section of Endocrinology, M. D. Anderson Hospital and Tumor Institute, 6723 Bertner Avenue, Houston, TX 77030===Search for more papers by this authorMichael Ibanez MD, FACP, Michael Ibanez MD, FACP Section of Endocrinology, Department of Medicine, and Department of Pathology, The University of Texas System Cancer Center M. D. Anderson Hospital and Tumor Institute, Houston, TexasSearch for more papers by this authorC. Stratton Hill Jr. MD, C. Stratton Hill Jr. MD Section of Endocrinology, Department of Medicine, and Department of Pathology, The University of Texas System Cancer Center M. D. Anderson Hospital and Tumor Institute, Houston, TexasSearch for more papers by this author First published: June 1978 https://doi.org/10.1002/1097-0142(197806)41:6<2267::AID-CNCR2820410627>3.0.CO;2-7Citations: 271AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Eighty-four cases of spindle and giant cell carcinoma of the thyroid were reviewed. This is a swiftly growing, and rapidly fatal neoplasm that generally develops in the elderly. Treatment of this disease was generally unsuccessful with a 7.1% five-year survival rate and a mean survival period of 6.2 months from the time of tissue diagnosis. In the majority of cases, areas of well-differentiated thyroid carcinoma could be identified, supporting the concept that spindle and giant cell carcinoma results from the transformation of preexisting well-differentiated thyroid carcinoma. Because of the aggressive biologic activity of this neoplasm, we treat all cases as disseminated disease at the time of presentation. Our best therapeutic results have been obtained with a combination of surgery, irradiation, and chemotherapy; however, these results still leave much to be desired. Patients with only small foci of spindle and giant cell carcinoma, at the time of diagnosis, may have a better chance of prolonged survival. Citing Literature Volume41, Issue6June 1978Pages 2267-2275 ReferencesRelatedInformation
Publication Year: 1978
Publication Date: 1978-06-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 368
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