Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2157700724', 'doi': 'https://doi.org/10.1002/glia.22484', 'title': 'Molecular mechanism of histamine clearance by primary human astrocytes', 'display_name': 'Molecular mechanism of histamine clearance by primary human astrocytes', 'publication_year': 2013, 'publication_date': '2013-03-15', 'ids': {'openalex': 'https://openalex.org/W2157700724', 'doi': 'https://doi.org/10.1002/glia.22484', 'mag': '2157700724', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23505051'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/glia.22484', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/glia.22484', 'source': {'id': 'https://openalex.org/S147407642', 'display_name': 'Glia', 'issn_l': '0894-1491', 'issn': ['0894-1491', '1098-1136'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/glia.22484', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024105175', 'display_name': 'Takeo Yoshikawa', 'orcid': 'https://orcid.org/0000-0002-7056-6021'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Takeo Yoshikawa', 'raw_affiliation_strings': ['Department of Pharmacology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018743831', 'display_name': 'Fumito Naganuma', 'orcid': 'https://orcid.org/0000-0003-3242-2905'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Fumito Naganuma', 'raw_affiliation_strings': ['Department of Pharmacology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5114094616', 'display_name': 'Tomomitsu Iida', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tomomitsu Iida', 'raw_affiliation_strings': ['Department of Pharmacology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081449138', 'display_name': 'Tadaho Nakamura', 'orcid': 'https://orcid.org/0000-0002-6206-7994'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tadaho Nakamura', 'raw_affiliation_strings': ['Department of Pharmacology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028540036', 'display_name': 'Ryuichi Harada', 'orcid': 'https://orcid.org/0000-0001-8538-8814'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ryuichi Harada', 'raw_affiliation_strings': ['Department of Pharmacology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049385580', 'display_name': 'Attayeb Mohsen', 'orcid': 'https://orcid.org/0000-0003-0690-8012'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Attayeb S. Mohsen', 'raw_affiliation_strings': ['Department of Pharmacology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068677726', 'display_name': 'Atsuko Kasajima', 'orcid': 'https://orcid.org/0000-0002-1130-1744'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Atsuko Kasajima', 'raw_affiliation_strings': ['Department of Pathology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015575554', 'display_name': 'Hironobu Sasano', 'orcid': 'https://orcid.org/0000-0002-6600-8641'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hironobu Sasano', 'raw_affiliation_strings': ['Department of Pathology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035847289', 'display_name': 'Kazuhiko Yanai', 'orcid': 'https://orcid.org/0000-0001-9068-7907'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuhiko Yanai', 'raw_affiliation_strings': ['Department of Pharmacology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5024105175'], 'corresponding_institution_ids': ['https://openalex.org/I201537933'], 'apc_list': {'value': 4940, 'currency': 'USD', 'value_usd': 4940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.612, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 99, 'citation_normalized_percentile': {'value': 0.889854, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '61', 'issue': '6', 'first_page': '905', 'last_page': '916'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11346', 'display_name': 'Mast cells and histamine', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11346', 'display_name': 'Mast cells and histamine', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11924', 'display_name': 'Polyamine Metabolism and Applications', 'score': 0.9842, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Enzymes and Metabolism', 'score': 0.9769, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/histaminergic', 'display_name': 'Histaminergic', 'score': 0.9227059}, {'id': 'https://openalex.org/keywords/histamine-n-methyltransferase', 'display_name': 'Histamine N-methyltransferase', 'score': 0.82191706}, {'id': 'https://openalex.org/keywords/human-brain', 'display_name': 'Human brain', 'score': 0.46879798}], 'concepts': [{'id': 'https://openalex.org/C2778501154', 'wikidata': 'https://www.wikidata.org/wiki/Q18349602', 'display_name': 'Histaminergic', 'level': 3, 'score': 0.9227059}, {'id': 'https://openalex.org/C1122143', 'wikidata': 'https://www.wikidata.org/wiki/Q61233', 'display_name': 'Histamine', 'level': 2, 'score': 0.9171952}, {'id': 'https://openalex.org/C187507357', 'wikidata': 'https://www.wikidata.org/wiki/Q18027062', 'display_name': 'Histamine N-methyltransferase', 'level': 5, 'score': 0.82191706}, {'id': 'https://openalex.org/C189613389', 'wikidata': 'https://www.wikidata.org/wiki/Q70479817', 'display_name': 'Organic cation transport proteins', 'level': 4, 'score': 0.64348465}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6033744}, {'id': 'https://openalex.org/C2777670902', 'wikidata': 'https://www.wikidata.org/wiki/Q492038', 'display_name': 'Human brain', 'level': 2, 'score': 0.46879798}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.42024383}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.4054377}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.40280613}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.35146257}, {'id': 'https://openalex.org/C34400551', 'wikidata': 'https://www.wikidata.org/wiki/Q311568', 'display_name': 'Histamine H2 receptor', 'level': 4, 'score': 0.26584923}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.14454603}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.093928814}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.068861485}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001253', 'descriptor_name': 'Astrocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006632', 'descriptor_name': 'Histamine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006637', 'descriptor_name': 'Histamine N-Methyltransferase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001253', 'descriptor_name': 'Astrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001692', 'descriptor_name': 'Biological Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D033705', 'descriptor_name': 'Equilibrative Nucleoside Transport Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D033705', 'descriptor_name': 'Equilibrative Nucleoside Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D033705', 'descriptor_name': 'Equilibrative Nucleoside Transport Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006632', 'descriptor_name': 'Histamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006637', 'descriptor_name': 'Histamine N-Methyltransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006637', 'descriptor_name': 'Histamine N-Methyltransferase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D027701', 'descriptor_name': 'Organic Cation Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027701', 'descriptor_name': 'Organic Cation Transport Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D027701', 'descriptor_name': 'Organic Cation Transport Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000075102', 'descriptor_name': 'Organic Cation Transporter 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/glia.22484', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/glia.22484', 'source': {'id': 'https://openalex.org/S147407642', 'display_name': 'Glia', 'issn_l': '0894-1491', 'issn': ['0894-1491', '1098-1136'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23505051', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/glia.22484', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/glia.22484', 'source': {'id': 'https://openalex.org/S147407642', 'display_name': 'Glia', 'issn_l': '0894-1491', 'issn': ['0894-1491', '1098-1136'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.7, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1493374490', 'https://openalex.org/W1514069950', 'https://openalex.org/W1533063439', 'https://openalex.org/W1545793778', 'https://openalex.org/W1961819790', 'https://openalex.org/W1965477067', 'https://openalex.org/W1966752296', 'https://openalex.org/W1968695161', 'https://openalex.org/W1969987252', 'https://openalex.org/W1974283364', 'https://openalex.org/W1977984786', 'https://openalex.org/W1983412227', 'https://openalex.org/W1986732006', 'https://openalex.org/W1988629728', 'https://openalex.org/W1994024795', 'https://openalex.org/W2022628868', 'https://openalex.org/W2025894603', 'https://openalex.org/W2026415168', 'https://openalex.org/W2033429037', 'https://openalex.org/W2034577877', 'https://openalex.org/W2044134989', 'https://openalex.org/W2045804248', 'https://openalex.org/W2068293422', 'https://openalex.org/W2072432859', 'https://openalex.org/W2074596241', 'https://openalex.org/W2074661552', 'https://openalex.org/W2077046090', 'https://openalex.org/W2079796186', 'https://openalex.org/W2086778453', 'https://openalex.org/W2087538875', 'https://openalex.org/W2096174019', 'https://openalex.org/W2098258490', 'https://openalex.org/W2111210621', 'https://openalex.org/W2114808045', 'https://openalex.org/W2117919289', 'https://openalex.org/W2123035658', 'https://openalex.org/W2124498834', 'https://openalex.org/W2125788269', 'https://openalex.org/W2125864071', 'https://openalex.org/W2140663299', 'https://openalex.org/W2141816565', 'https://openalex.org/W2171485147', 'https://openalex.org/W2171629666', 'https://openalex.org/W2413791627', 'https://openalex.org/W4233041464', 'https://openalex.org/W67809919'], 'related_works': ['https://openalex.org/W4226022402', 'https://openalex.org/W3194807765', 'https://openalex.org/W3156289559', 'https://openalex.org/W2756225471', 'https://openalex.org/W2056970245', 'https://openalex.org/W2055114361', 'https://openalex.org/W2052888437', 'https://openalex.org/W1986034633', 'https://openalex.org/W1786528573', 'https://openalex.org/W1601442925'], 'abstract_inverted_index': {'Histamine': [0, 106, 123], 'clearance': [1, 32, 214], 'is': [2, 77, 124, 215], 'an': [3], 'essential': [4], 'process': [5], 'for': [6, 79, 130, 204], 'avoiding': [7], 'excessive': [8], 'histaminergic': [9, 246], 'neuronal': [10], 'activity.': [11], 'Previous': [12], 'studies': [13], 'using': [14], 'rodents': [15], 'revealed': [16, 62, 154, 185], 'the': [17, 27, 50, 68, 75, 116, 172, 186, 192, 205, 209, 236, 243], 'predominant': [18], 'role': [19, 234], 'of': [20, 30, 52, 174, 189, 195, 212, 238, 245], 'astrocytes': [21, 48, 51, 87, 111, 173, 231], 'in': [22, 45, 90, 103, 161, 171, 229, 235], 'brain': [23, 54, 176], 'histamine': [24, 31, 38, 72, 80, 89, 104, 198, 213, 240], 'clearance.': [25], 'However,': [26], 'molecular': [28, 210], 'mechanism': [29, 211], 'has': [33], 'remained': [34], 'unclear.': [35], 'We': [36, 82], 'detected': [37], 'N': [39], '‐methyltransferase': [40], '(HNMT),': [41], 'a': [42, 91, 128, 233], 'histamine‐metabolizing': [43], 'enzyme,': [44], 'primary': [46, 85, 109, 162, 217], 'human': [47, 53, 86, 110, 163, 175, 218, 230], 'and': [49, 58, 133, 146, 157, 168, 181, 191, 227, 242], 'specimens.': [55, 177], 'Immunocytochemical': [56], 'analysis': [57, 95, 153], 'subcellular': [59], 'fractionation': [60], 'assays': [61, 180, 184], 'that': [63, 71, 84, 97, 155, 208, 224], 'active': [64], 'HNMT': [65, 228], 'localized': [66], 'to': [67, 126, 197], 'cytosol,': [69], 'suggesting': [70], 'transport': [73], 'into': [74], 'cytosol': [76], 'crucial': [78], 'inactivation.': [81], 'showed': [83, 96], 'transported': [88], 'time‐dependent': [92], 'manner.': [93], 'Kinetics': [94], 'two': [98], 'low‐affinity': [99, 132], 'transporters': [100], 'were': [101, 159], 'involved': [102], 'transport.': [105, 199], 'uptake': [107], 'by': [108, 216], 'was': [112], 'not': [113], 'dependent': [114], 'on': [115], 'extracellular': [117], 'Na': [118, 134], '+': [119, 135], '/Cl': [120, 136], '−': [121, 137], 'concentration.': [122], 'reported': [125], 'be': [127], 'substrate': [129], 'three': [131], '‐independent': [138], 'transporters:': [139], 'organic': [140], 'cation': [141], 'transporter': [142, 150], '2': [143], '(OCT2),': [144], 'OCT3,': [145], 'plasma': [147], 'membrane': [148], 'monoamine': [149], '(PMAT).': [151], 'RT‐PCR': [152], 'OCT3': [156, 167, 196, 226], 'PMAT': [158, 169, 190], 'expressed': [160], 'astrocytes.': [164, 219], 'Immunohistochemistry': [165], 'confirmed': [166], 'expression': [170], 'Drug': [178], 'inhibition': [179], 'gene': [182], 'knockdown': [183], 'major': [187], 'contribution': [188, 194], 'minor': [193], 'The': [200], 'present': [201], 'study': [202], 'demonstrates': [203], 'first': [206], 'time': [207], 'These': [220], 'findings': [221], 'might': [222], 'indicate': [223], 'PMAT,': [225], 'play': [232], 'regulation': [237], 'extraneuronal': [239], 'concentration': [241], 'activities': [244], 'neurons.': [247]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2157700724', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 16}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 19}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 7}], 'updated_date': '2025-01-08T13:40:24.814214', 'created_date': '2016-06-24'}