FoxO3a Transcriptional Regulation of Bim Controls Apoptosis in Paclitaxel-treated Breast Cancer Cell Lines

Name: Work Video:
Duration: 3 min 30 s
Andrew Sunters; Silvia Fernández de Mattos; Marie Ståhl; Jan J. Brosens; Georgia Zoumpoulidou; Catherine Saunders; Paul J. Coffer; René H. Medema; R. Charles Coombes; Eric W.‐F. Lam
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2104, 2111, 3263, 3268, 3512, 3594], 'cancers,': [6, 231], 'but': [7, 232, 3220, 3854, 3895, 4114, 4311, 4331, 4348], 'the': [8, 22, 25, 55, 58, 75, 140, 158, 180, 194, 233, 247, 250, 280, 283, 300, 365, 383, 405, 419, 455, 462, 468, 480, 487, 508, 511, 557, 710, 717, 720, 730, 747, 762, 767, 795, 799, 901, 934, 939, 948, 995, 999, 1003, 1054, 1064, 1075, 1188, 1282, 1320, 1385, 1489, 1520, 1534, 1561, 1594, 1644, 1648, 1689, 1809, 1872, 1877, 1924, 1931, 1935, 1969, 1974, 1981, 1987, 2004, 2007, 2012, 2020, 2050, 2053, 2082, 2089, 2098, 2179, 2217, 2231, 2234, 2244, 2278, 2281, 2290, 2303, 2321, 2328, 2341, 2427, 2440, 2451, 2634, 2745, 2761, 2924, 2933, 2945, 2985, 3032, 3092, 3109, 3112, 3133, 3139, 3143, 3162, 3170, 3186, 3192, 3196, 3200, 3202, 3228, 3256, 3282, 3306, 3312, 3348, 3397, 3425, 3433, 3505, 3552, 3569, 3583, 3639, 3643, 3649, 3662, 3674, 3677, 3724, 3741, 3754, 3765, 3774, 3781, 3788, 3799, 3803, 3817, 3824, 3837, 3908, 3994, 4003, 4008, 4012, 4016, 4031, 4043, 4060, 4065, 4069, 4086, 4097, 4102, 4106, 4139, 4145, 4157, 4188, 4192, 4235, 4258, 4264, 4272, 4288, 4308, 4314, 4325, 4345], 'mechanisms': [9, 234, 3257, 3877], 'by': [10, 201, 235, 426, 590, 622, 806, 958, 1082, 1383, 1544, 1921, 1991, 2088, 2241, 2260, 2285, 2319, 2486, 2569, 2595, 2633, 2648, 2655, 2724, 2775, 3245, 3563, 3588, 3821, 4217], 'which': [11, 63, 72, 94, 106, 213, 236, 288, 297, 319, 331, 438, 587, 892, 1376, 1884, 2962, 3326, 3366, 3848, 3864, 3930, 3945, 4186, 4275], 'it': [12, 237, 627, 734, 793, 803], 'induces': [13, 238], 'apoptosis': [14, 97, 169, 187, 220, 239, 322, 394, 412, 445, 1410, 1791, 1990, 2021, 3261, 3285, 3309, 3331, 3371, 3586, 3820, 3840, 3858, 3869, 3882, 3940, 4046, 4195], 'are': [15, 240, 493, 528, 998, 1061, 1278, 1538, 1652, 1702, 1853, 1874, 1976, 3652, 3666, 3846, 3878, 4075], 'poorly': [16, 241], 'understood.': [17, 242], 'Consequently,': [18, 243, 1486, 2000, 3379], 'we': [19, 244, 2001, 2035, 3565, 3919, 4056, 4155], 'have': [20, 245, 2002, 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4154, 4266, 4274], 'were': [73, 298, 2127, 2316, 2338, 2395, 2411, 2459, 2484, 2496, 2534, 2546, 2679, 2730, 2848, 2951, 2958, 2982, 3045, 3057, 3072, 3094, 3115, 3272, 3322, 3359, 3383, 4176, 4191], 'paclitaxel-sensitive,': [74, 299], 'already': [76, 301], 'high': [77, 302, 3682, 3711, 3804, 3850, 3866, 3932], 'basal': [78, 303], 'levels': [79, 109, 159, 181, 207, 304, 334, 384, 406, 432, 488, 3571, 3584, 3617, 3644, 3660, 3826, 3851, 3867, 3872, 3933, 3948, 4236], 'Bim': [83, 92, 125, 163, 178, 183, 209, 308, 317, 350, 388, 403, 408, 434, 2074, 2182, 2219, 2264, 2305, 2373, 2959, 3012, 3181, 3216, 3230, 3233, 3437, 3704, 3809, 3828, 3915, 3937, 3952], 'protein': [84, 164, 184, 309, 389, 409, 776, 918, 941, 997, 1190, 1404, 1524, 2055, 2651, 2658, 2664, 3436, 3647, 4160, 4174, 4212], 'increased': [85, 206, 310, 431, 1184, 4299], 'dramatically': [86, 311, 4298], 'after': [87, 312, 3090, 3978, 4183, 4245, 4302], 'drug': [88, 313, 4184], 'treatment,': [89, 314, 3107, 4185], 'as': [90, 165, 167, 315, 390, 392, 942, 1017, 1069, 1560, 1813, 2346, 2514, 2631, 2739, 2778, 2826, 2909, 2942, 2964, 3734], 'did': [91, 316], 'mRNA,': [93, 318], 'induction.': [98, 323, 3841], 'This': [99, 192, 324, 417, 3209], 'not': [101, 326, 1998, 3152, 3222, 3856, 4116, 4281, 4312], 'observed': [102, 327, 1704, 3346, 4203, 4323], 'MDA-231': [104, 329], 'expressed': [107, 332, 3931, 3946], 'low': [108, 333, 3720, 3825, 3871, 3947], 'FoxOs': [111, 336, 1060, 1079, 1551, 1595, 1784, 3935, 3950, 4142], 'Bim.': [113, 144, 338, 369, 3794], 'Gene': [114, 145, 339, 370, 2175, 3037], 'reporter': [115, 340, 2376], 'experiments': [116, 147, 341, 372, 3382, 3671, 3924], 'demonstrated': [117, 342, 1529, 3672, 4223], 'cells': [121, 346, 1996, 2337, 2410, 2458, 2533, 2545, 2597, 2759, 3056, 3093, 3114, 3977, 4006, 4037, 4063, 4074, 4088, 4099, 4310], 'maximal': [122, 347, 4206], 'induction': [123, 348, 1988, 3310, 3818, 4259], 'promoter': [126, 351, 2183, 2265, 2306, 2325, 2374], 'dependent': [128, 353], 'on': [129, 354, 933, 1084, 1699, 2178, 2590, 2639, 3247], 'binding': [132, 357, 623, 1181, 1185], 'site,': [133, 358], 'suggesting': [134, 359, 1592, 3875], 'responsible': [138, 363, 2048, 3879], 'for': [139, 155, 177, 364, 380, 402, 1187, 1783, 2049, 2422, 2564, 2641, 2929, 2972, 3117, 3159, 3278, 3737, 3880, 4015, 4105], 'transcriptional': [141, 366], 'up-regulation': [142, 198, 367, 423, 2051], 'silencing': [146, 371], 'showed': [148, 373, 953, 3744], 'small': [150, 375, 928], 'interference': [151, 376, 573, 929], 'RNA': [152, 377, 2754, 2799, 2810, 2906, 2918], '(siRNA)': [153, 378], 'specific': [154, 176, 379, 401, 625, 2682], 'reduced': [157, 179, 382, 404], 'well': [166, 391, 2404], 'inhibited': [168, 186, 393, 411], 'paclitaxel-treated': [171, 189, 396, 414, 2457], 'cells.': [173, 191, 224, 398, 416, 449, 3885, 4316], 'Furthermore,': [174, 399, 1546, 3503], 'siRNA': [175, 400, 3043, 3129, 3182], 'first': [195, 420, 2935, 3140, 3193, 4017, 4107], 'demonstration': [196, 421], 'paclitaxel': [202, 427, 1886, 2101, 3099, 3277, 3377, 3589, 4079, 4149, 4165, 4248, 4305], 'can': [203, 214, 428, 439, 743, 1552, 1596, 1833, 3431], 'result': [204, 429, 1176], 'mRNA': [210, 435, 3217], 'protein,': [212, 437, 811], 'be': [215, 440, 744, 1655, 1834, 2093, 4205], 'direct': [217, 442], 'cause': [218, 443], 'Breast': [450, 3251, 3417, 4134], 'one': [453, 1875, 3784], 'most': [456, 1878, 3355, 4285], 'common': [457], 'malignancies': [458], 'affecting': [459], 'women': [460], 'western': [463], 'world': [464], 'arises': [466], 'following': [467, 2245, 2291, 2978, 3376, 4078, 4162], 'accumulation': [469, 2043], 'series': [472], 'somatic': [474], 'changes': [475, 492, 519, 524, 1638, 4158], 'serve': [477], 'increase': [479, 3329, 3339, 4001, 4029, 4233], 'rate': [481], 'proliferation': [484], 'and/or': [485], 'reduce': [486], 'These': [491, 523, 1174, 1634, 1918, 4081, 4336], 'often': [494, 529, 3509], 'found': [495, 4058], 'involve': [497], 'deregulation': [498], 'key': [500, 548, 880, 944, 1315], 'signal': [501, 549, 1982], 'transduction': [502, 505, 550, 1983], 'pathways.': [503], 'Signal': [504], 'pathways': [506, 1984], 'within': [507], 'transmit': [510], 'extracellular': [512], 'signals': [513], 'factors,': [516, 595, 1010, 2017], 'resulting': [517, 765, 1642, 2934], 'gene': [521, 526, 1318, 1398, 1640, 2771], 'expression.': [522, 1525], 'type-specific': [531], 'lead': [533], 'growth,': [536], 'differentiation,': [537], 'or': [538, 636, 1844, 2379, 2736, 3100, 3122, 3785, 4169], 'apoptosis,': [539, 2443, 3918], 'thereby': [540, 1310, 1391, 3441], 'regulating': [541, 3881], 'normal': [542], 'tissue': [543], 'structure': [544], 'function.': [546], 'One': [547, 1314], 'pathway': [551, 575, 1491, 1651, 1691, 2091, 3507], 'highly': [552, 1085], 'conserved': [553, 1086], 'eukaryotes': [555], 'phosphatidylinositol': [558, 759, 770, 916], '3-kinase': [559, 917], '(PI3K)': [560], '1The': [561], 'abbreviations': [562], 'are:': [564], 'PI3Kphosphatidylinositol': [565], '3-kinasePKBprotein': [566], 'kinase': [567, 569, 618, 777, 885, 919, 922, 1322, 1386], 'BCKIcyclin-dependent': [568], 'inhibitorPBSphosphate-buffered': [570], 'salineGAPDHglyceraldehyde-3-phosphate': [571], 'dehydrogenasesiRNAsmall': [572], 'RNA.': [574, 930], '(1.Cantley': [576, 603, 645, 813, 905], 'L.C.': [577, 604, 646, 814, 906, 2188], 'Science.': [578, 605, 647, 815, 907], '2002;': [579, 606, 648, 816, 908, 1822, 1862, 2895, 3495, 3543], '296:': [580, 607, 649, 817, 909], '1655-1657Crossref': [581, 608, 650, 818, 910], 'PubMed': [582, 609, 651, 680, 702, 819, 848, 870, 911, 970, 1032, 1107, 1141, 1169, 1207, 1241, 1269, 1305, 1338, 1371, 1439, 1464, 1481, 1587, 1629, 1681, 1742, 1776, 1825, 1865, 1898, 1913, 1948, 1963, 2208, 2358, 2529, 2790, 2838, 2873, 2898, 3473, 3498, 3546], 'Scopus': [583, 610, 652, 681, 703, 820, 849, 871, 912, 971, 1033, 1108, 1142, 1170, 1208, 1242, 1270, 1306, 1339, 1372, 1440, 1465, 1482, 1588, 1630, 1682, 1743, 1826, 1866, 1899, 1914, 1949, 1964, 2209, 2359, 2791, 2839, 2874, 2899, 3474, 3499, 3547], '(4657)': [584, 611, 653, 821, 913], 'Google': [585, 612, 654, 683, 705, 822, 851, 873, 914, 973, 1035, 1110, 1144, 1172, 1210, 1244, 1272, 1308, 1341, 1374, 1442, 1467, 1484, 1590, 1632, 1684, 1745, 1777, 1828, 1868, 1901, 1916, 1951, 1966, 2211, 2361, 2530, 2793, 2841, 2876, 2901, 3476, 3501, 3534, 3549], 'Scholar),': [586, 1309, 1375, 1591, 1778, 2212, 3550], 'stimulated': [589], 'number': [592, 878, 3148, 3207, 4032, 4061, 4070], 'growth': [594, 600, 897, 1057, 1496], 'including': [596, 882], 'insulin': [597, 639], 'insulin-like': [599], 'factor': [601, 903, 1058], '1': [602, 2368, 2565, 2617], 'Scholar).': [613, 706, 874, 915, 990, 1052, 1173, 1273, 1485, 1633, 1829, 1869, 1917, 1967, 2362, 2531, 2794, 2842, 2902, 3502], 'Once': [614], 'receptor': [616, 640, 718], 'tyrosine': [617], 'has': [619, 1527, 3421], 'become': [620, 1080, 4112], 'activated': [621, 753, 805, 1543], 'ligand,': [626], 'becomes': [628, 804], 'autophosphorylated': [629], 'binds': [631, 774], 'PI3K': [632, 715, 726, 742, 757, 1076, 1490], 'heterodimers': [633], 'either': [634, 3118, 4167], 'directly,': [635], 'indirectly': [637], 'via': [638, 750, 786, 1600], 'substrate': [641, 946], '(IRS)': [642], 'adaptor': [643], 'proteins': [644], 'Scholar,': [655, 684, 823, 852, 974, 1036, 1111, 1145, 1211, 1245, 1342, 1443, 1468, 1746, 1902, 1952, 2877, 3477, 3535], '2.Vanhaesebroeck': [656, 824], 'B.': [657, 686, 825, 854, 1715], 'Jones': [658, 826], 'G.E.': [659, 827], 'Allen': [660, 828], 'W.E.': [661, 829], 'Zicha': [662, 830], 'D.': [663, 831, 1764], 'Hooshmand-Rad': [664, 832], 'R.': [665, 833, 1094, 1194, 1327, 1713, 1729, 1760, 1768], 'Sawyer': [666, 834], 'C.': [667, 669, 835, 837, 1348, 1416, 3450, 3515], 'Wells': [668, 836], 'Waterfield': [670, 691, 838, 859], 'M.D.': [671, 692, 839, 860], 'Ridley': [672, 840], 'A.J.': [673, 841], 'Nat.': [674, 842, 1819, 1859], 'Cell.': [675, 843, 1132, 1232, 1366, 1434, 3468], 'Biol.': [676, 844, 1159, 1259, 1367, 1435, 1455, 1477, 1577, 1619, 2894, 3469, 3494], '1999;': [677, 845, 1133, 1161, 1233, 1261, 1302, 1739, 1910, 1960], '1:': [678, 846], '69-71Crossref': [679, 847], '(201)': [682, 850], '3.Vanhaesebroeck': [685, 853], 'Leevers': [687, 855], 'S.J.': [688, 856], 'Panayotou': [689, 857], 'G.': [690, 858, 1149, 1249, 1663, 1671, 3537], 'Trends': [693, 861], 'Biochem.': [694, 862], 'Sci.': [695, 863, 1298], '1997;': [696, 864, 2526], '22:': [697, 865], '267-272Abstract': [698, 866], 'Full': [699, 867, 1102, 1104, 1136, 1138, 1164, 1166, 1202, 1204, 1236, 1238, 1264, 1266, 1459, 1461, 1582, 1584, 1624, 1626], 'Text': [700, 868, 1103, 1105, 1137, 1139, 1165, 1167, 1203, 1205, 1237, 1239, 1265, 1267, 1460, 1462, 1583, 1585, 1625, 1627], 'PDF': [701, 869, 1106, 1140, 1168, 1206, 1240, 1268, 1463, 1586, 1628], '(833)': [704, 872], 'The': [707, 991, 2262, 2310, 2409, 2955, 2977, 3127, 3180, 3292, 3317, 3354, 3401, 3598, 3626, 3658, 3701, 3728, 3842, 3959, 3984, 4211, 4220], 'interaction': [708, 1601], 'between': [709, 3341, 3773], 'p85': [711], 'regulatory': [712, 1515], 'subunit': [713], 'brings': [719], 'catalytic': [721], 'domain': [722, 790, 1403], '(p110': [723], 'subunit)': [724], 'into': [727, 2327], 'contact': [728], 'plasma': [731, 748], 'membrane,': [732], 'where': [733, 802, 1066], 'able': [736], 'phosphorylate': [738], 'its': [739, 787, 1888, 3579, 3708], 'targets.': [740], 'Alternatively,': [741], 'juxtaposed': [745], 'membrane': [749, 801, 2818], 'interactions': [751], 'RAS': [754], 'family': [755, 1005, 2014, 2086, 3427, 3554, 3912], 'members.': [756], 'phosphorylates': [758, 876], '(4,5)-diphosphate': [760], 'at': [761, 2157, 2692, 2703, 4166], '3': [763], 'position,': [764], 'formation': [768], '(3,4,5)-triphosphate.': [771], 'Phosphatidylinositol': [772], '(3,4,5)-triphosphate': [773], 'B': [778, 920], '(PKB)': [779], 'also': [780, 1518, 1597, 2079, 3705, 3834, 4322], 'called': [781], 'AKT,': [782], 'serine/threonine': [784], 'kinase,': [785], 'pleckstrin': [788, 808], 'homology': [789, 809], 'recruits': [792], 'inner': [796], 'surface': [797], 'another': [807], 'domain-containing': [810], 'PDK1': [812], 'PKB': [875, 959, 1083, 1661], 'substrates,': [881], 'glycogen': [883], 'synthase': [884], '3β': [886], 'mammalian': [888, 992], 'rapamycin,': [891], 'involved': [894, 1985, 3258], 'translation,': [899], 'NFκB': [904], 'cyclin-dependent': [921, 1321], 'inhibitor': [923, 1323, 2629], 'phosphate-buffered': [924], 'saline': [925], 'glyceraldehyde-3-phosphate': [926], 'dehydrogenase': [927], 'Genetic': [931], 'studies': [932], 'nematode': [935], 'Caenorhabditis': [936], 'elegans': [937], 'identified': [938], 'DAF16': [940, 955, 996], 'downstream': [945], 'insulin/PI3K/PKB': [949], 'signaling': [950, 1077, 1650], 'pathway,': [951, 2009], 'inactivated': [957], 'phosphorylation': [960, 3562], '(4.Birkenkamp': [961, 1023], 'K.U.': [962, 1024, 2881, 3481], 'Coffer': [963, 1025, 1363, 1431, 1452, 1471, 2890, 3465, 3490], 'P.J.': [964, 1026, 1364, 1432, 1453, 1472, 2891, 3466, 3491], 'J.': [965, 1027, 1129, 1158, 1229, 1258, 1288, 1470, 1474, 1475, 1576, 1618, 1677, 1770, 1908, 1958, 2354, 2786, 2834, 2860, 2892, 3492, 3523, 3527, 3529, 3541], 'Immunol.': [966, 1028], '2003;': [967, 1029, 1099, 1199, 1478], '171:': [968, 1030], '1623-1629Crossref': [969, 1031], '(136)': [972, 1034], '5Tran,': [975, 1037], 'H.,': [976, 1038], 'Brunet,': [977, 1039], 'A.,': [978, 1040], 'Griffith,': [979, 1041], 'E.': [980, 985, 1042, 1047], 'C.,': [981, 1043], 'Greenberg,': [983, 1045], 'M.': [984, 1046, 1092, 1192, 1569, 1611, 1669, 1675, 1727, 1758, 3517], '(2003)': [986, 1048], "Science's": [987, 1049], 'STKE,': [988, 1050], 'http://stke.sciencemag.org/cgi/content/full/sigtrans;2003/53/re5.Google': [989, 1051], 'orthologues': [993], 'class': [1001], 'forkhead': [1004], 'winged': [1007], 'helix': [1008], 'FoxO1a,': [1011, 3642], 'FoxO3a,': [1012, 2070, 4127], 'FoxO4': [1014], '(formally': [1015], 'known': [1016, 3215, 3789], 'FKHR,': [1018], 'FKHR-L1,': [1019], 'AFX,': [1021], 'respectively)': [1022], 'absence': [1055], 'stimulation,': [1059], 'localized': [1062], 'nucleus,': [1065], 'they': [1067], 'function': [1068], 'factors.': [1071], 'Upon': [1072], 'stimulation': [1073], 'cascade,': [1078], 'phosphorylated': [1081, 2691, 2702, 3650, 4294], 'serine': [1087], 'threonine': [1089], 'residues': [1090], '(6.Engstrom': [1091, 1191], 'Karlsson': [1093, 1193], 'Jonsson': [1095, 1195], 'J.I.': [1096, 1196], 'Exp.': [1097, 1197], 'Hematol.': [1098, 1198], '31:': [1100, 1200], '316-323Abstract': [1101, 1201], '(44)': [1109, 1209], '7.Brunet': [1112, 1212], 'A.': [1113, 1115, 1213, 1215, 1301, 1673, 1756], 'Bonni': [1114, 1214], 'Zigmond': [1116, 1216], 'M.J.': [1117, 1125, 1217, 1225, 2522], 'Lin': [1118, 1218, 1710, 3526], 'M.Z.': [1119, 1219], 'Juo': [1120, 1220], 'P.': [1121, 1155, 1221, 1255, 1733, 2186, 2196], 'Hu': [1122, 1222], 'L.S.': [1123, 1223], 'Anderson': [1124, 1224], 'Arden': [1126, 1226, 1293], 'K.C.': [1127, 1227, 1294], 'Blenis': [1128, 1228], 'Greenberg': [1130, 1230], 'M.E.': [1131, 1231], '96:': [1134, 1234, 1303], '857-868Abstract': [1135, 1235], '(5434)': [1143, 1243], '8.Guo': [1146, 1246], 'S.': [1147, 1151, 1247, 1251, 1300, 1667, 1816, 1856], 'Rena': [1148, 1248], 'Cichy': [1150, 1250], 'He': [1152, 1252], 'X.': [1153, 1253, 1717, 1752, 3519], 'Cohen': [1154, 1254], 'Unterman': [1156, 1256], 'T.': [1157, 1257, 1290, 1725, 1906, 1956], 'Chem.': [1160, 1260, 1578, 1620], '274:': [1162, 1262], '17184-17192Abstract': [1163, 1263], '(469)': [1171, 1271], 'phosphorylations': [1175], 'impairment': [1178], 'DNA': [1180, 2240, 4040], 'ability': [1182], 'affinity': [1186], '14-3-3': [1189], 'Newly': [1274], 'formed': [1275], '14-3-3-FoxO': [1276], 'complexes': [1277], 'then': [1279, 2267, 2317, 2412, 2539, 2547, 2567, 4111, 4201, 4215], 'exported': [1280], 'from': [1281, 1643, 2163, 2238, 2757, 3047, 3169, 3798, 4187], 'nucleus': [1283], '(9.Biggs': [1284], '3rd,': [1285], 'W.H.': [1286], 'Meisenhelder': [1287], 'Hunter': [1289], 'Cavenee': [1291], 'W.K.': [1292], 'Proc.': [1295], 'Natl.': [1296], 'Acad.': [1297], 'U.': [1299], '7421-7426Crossref': [1304], '(942)': [1307], 'inhibiting': [1311, 1384], 'FoxO-dependent': [1312], 'transcription.': [1313], '(CKI)': [1324], 'p27Kip1': [1325, 2721, 3680, 3792, 4130], '(10.Medema': [1326], 'Kops': [1328], 'G.J.P.L.': [1329], 'Bos': [1330], 'J.L.': [1331], 'Burgering': [1332, 1355, 1423, 3457], 'B.M.T.': [1333], 'Nature.': [1334], '2000;': [1335, 1368, 1436, 1456, 1678, 3470, 3531], '404:': [1336], '782-787Crossref': [1337], '(1226)': [1340], '11.Dijkers': [1343], 'P.F.': [1344, 1412, 1445, 2879, 3446, 3479], 'Medema': [1345, 1413, 3447], 'R.H.': [1346, 1414, 1447, 3448], 'Pals': [1347, 1415, 3449], 'Banerji': [1349, 1417, 3451], 'L.': [1350, 1362, 1418, 1430, 1451, 2858, 2889, 3452, 3464, 3489], 'Thomas': [1351, 1419, 2523, 2863, 2884, 3453, 3484], 'N.S.': [1352, 1420, 2524, 2864, 2885, 3454, 3485], 'Lam': [1353, 1421, 2867, 2882, 3455, 3482], 'E.W.': [1354, 1422, 3456], 'B.M.': [1356, 1424, 3458], 'Raaijmakers': [1357, 1425, 3459], 'J.A.': [1358, 1426, 3460], 'Lammers': [1359, 1427, 1448, 2886, 3461, 3486], 'J.W.': [1360, 1428, 1449, 2887, 3462, 3487], 'Koenderman': [1361, 1429, 1450, 2888, 3463, 3488], 'Mol.': [1365, 1433, 3467], '20:': [1369, 1437, 2871, 3471], '9138-9148Crossref': [1370, 1438, 3472], '(542)': [1373, 1441, 3475], 'serves': [1377, 1492], 'inhibit': [1379], 'cycle': [1381, 1789, 2506, 4014], 'progression': [1382], 'activity': [1387], 'cyclin-CDK': [1389], 'holoenzymes,': [1390], 'reducing': [1392], 'proliferation.': [1394], 'Another': [1395], 'important': [1396], 'BH3': [1402], 'capable': [1407, 1540], 'inducing': [1409], '(11.Dijkers': [1411, 3445], '12.Dijkers': [1444], 'Medemadagger': [1446], 'Curr.': [1454], '10:': [1457], '1201-1204Abstract': [1458], '(831)': [1466], '13.Gilley': [1469], 'Ham': [1473], 'Cell': [1476, 2106, 2503, 2580, 2687, 2695, 2893, 3253, 3419, 3493, 3888, 3893, 3902, 4136], '162:': [1479], '613-622Crossref': [1480], '(552)': [1483], 'activation': [1487], 'repress': [1494], 'FoxO-mediated': [1495], 'arrest': [1497, 4089], 'However,': [1500], 'regulation': [1501, 2083], 'genes': [1505], 'multifactorial,': [1507], 'therefore': [1509], 'other': [1510, 1556, 1603, 3155, 3225, 3786, 3876], 'post-translation': [1514], 'events': [1516], 'will': [1517], 'influence': [1519], 'final': [1521], 'level': [1522, 3283, 3675, 3805], 'It': [1526], 'been': [1528, 3422], 'some': [1531, 1840], 'promoters': [1532], 'lacking': [1533], 'consensus': [1536], 'site': [1537], 'still': [1539, 4261], 'being': [1542, 2471, 3698, 3710], 'FoxOs.': [1545], 'there': [1547, 2064, 3301, 3769, 3998, 4025, 4230], 'evidence': [1549], 'interact': [1553], 'strongly': [1554], 'such': [1559, 1812], 'estrogen': [1562, 1810], 'receptor-α': [1563], '(14.Schuur': [1564, 1606], 'E.R.': [1565, 1607], 'Loktev': [1566, 1608], 'A.V.': [1567, 1609], 'Sharma': [1568, 1610], 'Sun': [1570, 1612], 'Z.': [1571, 1613], 'Roth': [1572, 1614], 'R.A.': [1573, 1615], 'Weigel': [1574, 1616], 'R.J.': [1575, 1617, 2352, 2784, 2832], '2001;': [1579, 1621, 1773, 1895, 1945, 2205, 2870], '276:': [1580, 1622], '33554-33560Abstract': [1581, 1623], '(131)': [1589, 1631], 'modulate': [1598], 'results': [1635, 4082], 'suggest': [1636, 3751, 4084], 'arm': [1646], 'PI3K/PKB': [1649, 1690, 2008, 2090, 3506], 'likely': [1653], 'type-dependent.': [1657], 'Interestingly,': [1658, 4317], 'overexpression': [1659], '(15.Razzini': [1662], 'Berrie': [1664], 'C.P.': [1665], 'Vignati': [1666], 'Broggini': [1668], 'Mascetta': [1670], 'Brancaccio': [1672], 'Falasca': [1674], 'FASEB': [1676], '14:': [1679], '1179-1187Crossref': [1680], '(74)': [1683], 'Scholar)': [1685], 'inactivation': [1687], 'inhibitor,': [1692], 'PTEN': [1693], '(phosphatase': [1694], 'tensin': [1696], 'homologue': [1697], 'deleted': [1698], 'chromosome': [1700], 'TEN),': [1701], 'frequently': [1703, 1879], '(16.Lu': [1708], 'Y.': [1709, 1750], 'Y.Z.': [1711], 'LaPushin': [1712], 'Cuevas': [1714], 'Fang': [1716, 1751], 'Yu': [1718], 'S.X.': [1719], 'Davies': [1720], 'M.A.': [1721], 'Khan': [1722], 'H.': [1723, 1754], 'Furui': [1724], 'Mao': [1726, 1757], 'Zinner': [1728], 'Hung': [1730], 'M.C.': [1731], 'Steck': [1732], 'Siminovitch': [1734, 1765], 'K.': [1735, 1766, 3521], 'Mills': [1736], 'G.B.': [1737, 1748], 'Oncogene.': [1738, 2869], '18:': [1740], '7034-7045Crossref': [1741], '(267)': [1744], '17.Mills': [1747], 'Lu': [1749], 'Wang': [1753], 'Eder': [1755], 'Swaby': [1759], 'Cheng': [1761], 'K.W.': [1762], 'Stokoe': [1763], 'Jaffe': [1767], 'Gray': [1769], 'Semin.': [1771], 'Oncol.': [1772, 3530], '28:': [1774], '125-141Crossref': [1775], 'indicating': [1779], 'potential': [1781, 3391], 'modulating': [1786], 'both': [1787, 3108, 4226, 4238, 4293], 'during': [1792, 1938], 'tumorigenesis': [1793], 'treatment.': [1795, 3378, 4021, 4080], 'Typically,': [1796], 'treatment': [1797, 3979, 4163, 4249, 4253, 4306, 4329], 'involves': [1801], 'surgery': [1802], 'chemotherapy': [1804], 'using': [1805, 2243, 2289, 2302, 2340, 2426, 2489, 2498, 2510, 2572, 2579, 2667, 2732, 2744, 2760, 2767, 2802, 2821, 2850, 2923, 2984, 3006, 3031, 3080, 3288, 3970, 4052], 'drugs': [1806, 1919], 'receptor,': [1811], 'tamoxifen': [1814], '(18.Ali': [1815, 1855], 'Coombes': [1817, 1857], 'R.C.': [1818, 1858], 'Rev.': [1820, 1860], 'Cancer.': [1821, 1861, 1909, 1959, 3542], '2:': [1823, 1863], '101-112Crossref': [1824, 1864], '(704)': [1827, 1867], 'Although': [1830, 1968, 4042], 'anti-estrogen': [1831], 'therapy': [1832], 'effective': [1835], 'treating': [1837], 'estrogen-dependent': [1838], 'tumors,': [1839], 'tumors': [1841], 'exhibit': [1842], 'intrinsic': [1843], 'acquired': [1845], 'resistance': [1846], 'these': [1848, 3749, 3884, 3964], 'modalities,': [1849], 'alternative': [1851], 'treatments': [1852], 'needed': [1854], 'Of': [1870], 'these,': [1871], 'taxanes': [1873, 1975, 1992], 'classes': [1881], 'drugs,': [1883], 'include': [1885], 'derivatives': [1889], '(19.Symmans': [1890, 1940], 'F.W.': [1891, 1941], 'Drug': [1892, 1942], 'Resist.': [1893, 1943], 'Updat.': [1894, 1944], '4:': [1896, 1946], '297-302Crossref': [1897, 1947], '(14)': [1900, 1950], '20.Blagosklonny': [1903, 1953], 'M.V.': [1904, 1954], 'Fojo': [1905, 1955], 'Int.': [1907, 1957, 3528], '83:': [1911, 1961], '151-156Crossref': [1912, 1962], '(335)': [1915, 1965], 'act': [1920], 'interacting': [1922], 'microtubules,': [1926, 1977], 'particular,': [1929], 'microtubules': [1932], 'spindle': [1936], 'apparatus': [1937], 'mitosis': [1939], 'primary': [1970], 'targets': [1972, 3791], 'our': [1978], 'understanding': [1979], 'complete.': [1999], 'chiefly': [2011], 'mediating': [2019], 'survival': [2023], 'treated': [2029, 2417, 2758, 3095, 3273], 'this': [2033, 3845, 4318], 'report,': [2034], 'demonstrate': [2036, 3299, 4339], 'drug-sensitive': [2040, 3356], 'line': [2042, 2063, 3997], 'hypophosphorylated': [2045, 2069], 'whereas': [2057], 'less': [2060, 2073, 3333, 4269], 'sensitive': [2061, 3901], 'reduction': [2067], 'significantly': [2072], 'We': [2078], 'propose': [2080], 'members': [2087, 3913], 'may': [2092], 'prognostic': [2095], 'value': [2096], 'prediction': [2099], 'sensitivity': [2102, 3337], 'cancer.': [2105], 'Culture—A': [2107], 'human': [2110, 2218, 2263, 2304, 2720, 2852], 'carcinoma': [2112], 'HMT': [2115], '3522,': [2116], 'MCF-7,': [2117, 3361, 3684, 3714, 3755, 3812, 3929, 4347], '734': [2118], 'B,': [2119], 'ZR-75-1,': [2120, 3686, 3717, 3759, 3847], 'T47-D,': [2121], 'CAL-51,': [2122, 3633, 3689], 'CAMA-1,': [2123, 3363, 3634, 3694, 3863], 'MDA-MB-231,': [2124, 3635, 3695], 'SKBR-7': [2126, 3697, 3861], 'maintained': [2128], "Dulbecco's": [2130], 'modified': [2131], "Eagle's": [2132], 'medium': [2133, 3071], 'supplemented': [2134], '10%': [2136, 2155, 3375], 'fetal': [2137], 'bovine': [2138, 2467], 'serum,': [2139], '2': [2140, 3067, 3989], 'mm': [2141, 2607, 2610, 2615, 2618, 2622], 'glutamine,': [2142], '100': [2144, 2606], 'units/ml': [2145], 'penicillin/streptomycin,': [2146], 'humidified': [2149], 'incubator': [2150], 'an': [2152, 3022, 3328, 4000, 4232], 'atmosphere': [2153], 'CO2': [2156], '37': [2158], '°C.': [2159], 'obtained': [2162], 'Sigma': [2164], 'chemical': [2165], 'company': [2166], '(Poole': [2167], 'Dorset)': [2168], 'dissolved': [2170], 'Me2SO.': [2172], 'Transfections': [2173], 'Reporter': [2176, 2429], 'Assays—Based': [2177], 'published': [2180, 3201], 'mouse': [2181, 2716], 'sequence': [2184, 3130, 3183, 3210], '(21.Bouillet': [2185], 'Zhang': [2187], 'Huang': [2189, 3516], 'D.C.': [2190, 2520], 'Webb': [2191], 'G.C.': [2192], 'Bottema': [2193], 'C.D.': [2194, 2518], 'Shore': [2195], 'Eyre': [2197], 'H.J.': [2198], 'Sutherland': [2199], 'G.R.': [2200], 'Adams': [2201], 'J.M.': [2202], 'Mamm.': [2203], 'Genome.': [2204], '12:': [2206, 2356, 2788, 2836], '163-168Crossref': [2207], '(132)': [2210], '790-bp': [2214], 'fragment': [2215, 2326], 'promoter,': [2220], 'containing': [2221, 2367, 2465, 2559, 4038], 'single': [2223, 2272], 'inverse': [2224], 'Forkhead': [2225, 2282], 'box': [2226, 2283], 'TAAACAC': [2227], '(nucleotide–266/–259': [2228], 'relative': [2229, 3033, 3137, 3190], '3′terminus': [2232], 'promoter)': [2235], 'amplified': [2237], 'genomic': [2239, 3156], 'PCR': [2242, 2299], 'primers:': [2246, 2292], '5′-AAGCTTCCCGCCCTCACCCGGGA-3′': [2247], '5′-GAGCTCCAACAAACTGCAGACC-3′,': [2249], 'cloned': [2250], 'pGEM-T': [2252], 'easy': [2253], 'vector': [2254, 2331], '(Promega,': [2255, 2332], 'Southampton,': [2256], 'UK)': [2257, 3083], 'validated': [2259], 'sequencing.': [2261], 'mutated': [2268], 'introduce': [2270], 'G': [2273], 'C': [2275], 'substitution': [2276], 'core': [2279], '(GTAAACAC)': [2284], 'site-directed': [2286], 'point': [2287], 'mutagenesis': [2288], '5′-TTACTCCGGTAAAGACGCCAGGGA-3′': [2293], '5′-TCCCTGGCGTCTTTACCGGAGTAA-3′.': [2295], 'Subsequently,': [2296], 'double': [2298], 'performed': [2301, 2509, 2589, 2952, 3015, 3384], 'primers': [2307], 'described': [2308, 2347, 2515, 2827, 2855], 'before.': [2309], 'pGL2-hBim': [2311], 'pGL2-mutant': [2313], 'hBim': [2314], 'plasmids': [2315], 'created': [2318], 'cloning': [2320], 'respective': [2322], 'Klenow-blunted': [2323], 'EcoRI': [2324], 'SmaI-linearized': [2329], 'pGL2Basic': [2330], 'UK).': [2333], 'MDA-MB-231': [2336, 3055, 3323, 3833, 3943, 4098, 4153, 4265, 4315], 'transfected': [2339, 3073], 'calcium': [2342, 2364], 'phosphate': [2343, 2365], 'co-precipitation': [2344], 'method': [2345], 'previously': [2348, 2516, 2780, 2828, 2856], '(22.Lam': [2349, 2781, 2829], 'E.W.-F.': [2350, 2782, 2830, 2868, 2883, 3483], 'Watson': [2351, 2783, 2831], 'EMBO': [2353, 2785, 2833], '1993;': [2355, 2787, 2835], '2705-2713Crossref': [2357, 2789, 2837], '(317)': [2360, 2792, 2840], 'Briefly,': [2363, 2456, 2532, 2795], 'precipitates': [2366], 'μg': [2369, 2386, 2662, 2797, 3076], 'wild': [2371], 'type': [2372], 'firefly-luciferase': [2375], 'plasmid': [2377, 2381], '(pGL2-hBim)': [2378], 'mutant': [2380], '(pGL2-mutant-hBim)': [2382], 'together': [2383], '0.2': [2385], 'Renilla': [2389], 'luciferase': [2390, 2424], 'transfection': [2391, 3091], 'control': [2392, 2966, 3236, 3240, 3736], '(pRL-TK;': [2393], 'Promega)': [2394], 'incubated': [2396, 2680], 'overnight': [2397], 'subconfluent': [2399], 'cultures': [2401], 'each': [2403, 3002], '24-well': [2407], 'plate.': [2408], 'washed': [2413, 2462, 2536, 2548], 'twice': [2414, 2549], 'PBS,': [2416, 2538], 'paclitaxel,': [2419, 4257], 'harvested': [2421], 'firefly/Renilla': [2423], 'assays': [2425], 'Dual-Luciferase': [2428], 'Assay': [2430], 'System': [2431, 2928, 3028], '(Promega).': [2432], 'Apoptosis': [2433, 3243], 'Determination': [2434], 'Using': [2435], 'Annexin': [2436, 2444, 3123], 'V': [2437, 2445, 2477, 3290, 4054], 'Staining—To': [2438], 'determine': [2439, 3577], 'extent': [2441, 3307], 'staining': [2446, 2513], 'according': [2449, 3084], "manufacturer's": [2452, 3086], 'instructions': [2453], '(R&D': [2454, 2481], 'Systems).': [2455, 2482], 'trypsinized': [2460], 'PBS': [2464, 2551], '2%': [2466], 'serum': [2468], 'albumin,': [2469], 'before': [2470, 2910, 4093], 'stained': [2472, 2553], 'fluorescein': [2474], 'isothiocyanate-labeled': [2475], 'annexin': [2476, 3289, 4053, 4072], 'propidium': [2479, 2511, 2557, 3975], 'iodide': [2480, 2512, 2558, 3125], 'Cells': [2483, 3065], 'analyzed': [2485, 2568, 2578, 2774, 2957, 4216], 'flow': [2487, 2570, 3971], 'cytometry': [2488, 2571, 3972], 'FACScan': [2491, 2574], '(BD': [2492, 2501, 2575, 2583, 2712], 'Biosciences),': [2493], 'data': [2495, 3293, 3750, 3800, 3985, 4221, 4337], 'processed': [2497], 'CellQuest': [2499], 'software': [2500, 2582], 'Biosciences).': [2502, 2584, 2750], 'Cycle': [2504], 'Analysis—Cell': [2505], 'analysis': [2507], '(23.Williams': [2517], 'Linch': [2519], 'Watts': [2521], 'Blood.': [2525], '90:': [2527], '194-203Crossref': [2528], 'trypsinized,': [2535], 'fixed': [2540], '90%': [2542], 'ethanol.': [2543], 'Fixed': [2544], '50': [2555], 'μm': [2556], '5': [2560, 3342], 'μg/ml': [2561], 'DNase-free': [2562], 'RNase': [2563], 'h,': [2566, 3280, 4024], 'Biosciences)': [2576, 2820], 'Quest': [2581], 'Blotting—Western': [2586], 'whole': [2591], 'extracts': [2593, 4175], 'prepared': [2594, 4177], 'lysing': [2596], 'Nonidet': [2599, 2604], 'P-40': [2600], 'lysis': [2601], 'buffer': [2602], '(1%': [2603], 'P-40,': [2605], 'NaCl,': [2608], '20': [2609, 2661], 'Tris-HCl,': [2611], 'pH': [2612], '7.4,': [2613], '10': [2614, 3097, 3275, 3981, 4168, 4246, 4303], 'NaF,': [2616], 'sodium': [2619], 'orthovanadate,': [2620], '30': [2621], 'Naβ-glycerophosphate,': [2623], 'protease': [2625, 2628], 'inhibitors': [2626], '(“Complete”': [2627], 'mixture,': [2630], 'instructed': [2632], 'manufacturer,': [2635], 'Roche': [2636], 'Applied': [2637], 'Science))': [2638], 'ice': [2640], '15': [2642], 'min.': [2643], 'Insoluble': [2644], 'material': [2645], 'removed': [2647], 'centrifugation,': [2649], 'concentration': [2652], 'determined': [2654, 3005, 3733], 'Bio-Rad': [2656], 'Dc': [2657], 'assay': [2659], '(Bio-Rad).': [2660], 'size-fractionated': [2666, 2801], 'SDS-PAGE,': [2668], 'electro-transferred': [2670], 'onto': [2671, 2813], 'Protran': [2672], 'nitrocellulose': [2673, 2817], 'membranes': [2674], '(Schleicher': [2675], 'Schuell).': [2677], 'Membranes': [2678], 'antibodies': [2683, 2729], 'recognizing': [2684, 2719], 'FKHR/FoxO1a': [2685, 2690], '(9462s,': [2686], 'Signaling': [2688, 2696], 'Technologies),': [2689, 2697], 'Ser-253': [2693, 2704], '(9461s,': [2694], 'FKHR-L1/FoxO3a': [2698], '(Upstate': [2699, 2705], '06951),': [2700], 'FKHR-L1/FOXO3a': [2701], '06953),': [2706], 'BIM': [2707], '(Calbiochem,': [2708], '202000),': [2709], 'β-tubulin': [2711, 3731], 'Pharmingen': [2713], '556321).': [2714], 'A': [2715], 'monoclonal': [2717], 'antibody': [2718], 'generated': [2723], 'Dr.': [2725], 'Eric': [2726], 'Lam.': [2727], 'Primary': [2728], 'detected': [2731, 2849], 'horseradish': [2733], 'peroxidase-linked': [2734], 'anti-mouse': [2735], 'anti-rabbit': [2737], 'conjugates': [2738], 'appropriate': [2740], '(DAKO),': [2741], 'visualized': [2743], 'ECL': [2746], 'detection': [2747], 'system': [2748], '(Amersham': [2749, 2819], 'Northern': [2751, 2776, 2824], 'Blotting': [2752], 'Analysis—Total': [2753], 'isolated': [2756, 2908], 'RNeasy': [2762], 'kit': [2763], '(Qiagen)': [2764], 'quantitated': [2766], 'UV': [2768], 'spectrophotometry,': [2769], 'detailed': [2779], '40': [2796], '1.5%': [2803], '(w/v)': [2804], 'formaldehyde-agarose': [2805], 'gel': [2806], 'electrophoresis.': [2807], 'Following': [2808, 4252], 'electrophoresis,': [2809], 'transferred': [2812], 'Hybond': [2815], 'N+': [2816], 'capillary': [2822], 'transfer': [2823], 'p27Kip1,': [2844], 'GAPDH': [2846], 'mRNAs': [2847, 2956], '32P-labeled': [2851], 'cDNA': [2853, 2937, 3204], 'probes': [2854], '(24.Banerji': [2857], 'Glassford': [2859], 'Lea': [2861], 'N.C.': [2862], 'Klaus': [2865], 'G.G.': [2866], '7352-7367Crossref': [2872], '(51)': [2875], '25.Dijkers': [2878, 3478], 'Birkenkamp': [2880, 3480], '156:': [2896, 3496], '531-542Crossref': [2897, 3497], '(318)': [2900, 3500], 'Real-time': [2903], 'Quantitative': [2904], 'RT-PCR—Total': [2905], 'DNase': [2912], 'I-treated.': [2913], 'Equal': [2914], 'amounts': [2915], 'total': [2917, 3602, 3646, 4241, 4296], '(2': [2919], 'μg)': [2920], 'reverse-transcribed': [2922], 'Superscript': [2925], 'First-Strand': [2926], 'Synthesis': [2927], 'RT-PCR': [2930], '(Invitrogen),': [2931], 'strand': [2936], 'diluted': [2939], 'template': [2943], 'real-time': [2946], 'quantitative-PCR': [2947], 'analysis.': [2948], 'All': [2949], 'measurements': [2950], 'triplicate.': [2954], 'GAPDH,': [2961], 'served': [2963], 'internal': [2965], 'normalize': [2971], 'variances': [2973], 'input': [2975], 'cDNA.': [2976], 'gene-specific': [2979], 'primer': [2980, 3003], 'pairs': [2981], 'designed': [2983], 'ABI': [2986, 3023], 'Primer': [2987], 'Express': [2988], 'software:': [2989], 'GAPDH-sense': [2990], '(5′-ATTTGGTCGTATTGGGCGCCTGGTCACC-3′)': [2991], 'GAPDH-antisense': [2993], '(5′-GAAGATGGTGATGGGATTTC-3′);': [2994], 'Bim-sense': [2995], '(5′-CACAAAACCCCAAGTCCTCCTT-3′)': [2996], 'Bim-antisense': [2998], '(5′-TTCAGCCTGCCTCATGGAA-3′).': [2999], 'Specificity': [3000], 'NCBI': [3007, 3171], 'BLAST': [3008], 'module.': [3009], 'Detection': [3010, 3027], 'SYBR': [3017], 'Green': [3018], '(Applied': [3019, 3029], 'Biosystems)': [3020], 'PRISM': [3024], '7700': [3025], 'Sequence': [3026], 'Biosystems),': [3030], 'standard': [3034], 'curve': [3035], 'method.': [3036], 'Silencing': [3038], 'Small': [3040], 'Interfering': [3041], 'RNAs—The': [3042], 'oligonucleotides': [3044, 3079], 'purchased': [3046], 'Dharmacon': [3048], 'Research': [3049], 'Inc.': [3050], '(Lafayette,': [3051], 'CO).': [3052], 'cultured': [3058], 'six-well': [3060], 'plates': [3061], 'until': [3062], '60%': [3063], 'confluent.': [3064], 'ml': [3068], 'culture': [3070], '4': [3075], 'annealed': [3078], 'LipofectAMINE': [3081], '(Invitrogen,': [3082], 'instructions.': [3087], '24': [3088, 4018, 4023, 4108], 'h': [3089, 3105, 4019, 4109, 4182, 4244, 4301], 'nm': [3098, 3276, 3982, 4247, 4256, 4304, 4327], 'Me2SO': [3101], 'vehicle.': [3102], 'After': [3103, 4022], '48': [3104, 3279, 4243, 4300], 'suspension': [3110], 'adherent': [3113], 'collected': [3116], 'blot': [3120], 'analysis,': [3121], 'V/propidium': [3124], 'staining.': [3126, 3291], 'corresponds': [3131, 3184], 'coding': [3134, 3187], 'region': [3135, 3188], '46–64': [3136], 'nucleotide': [3141, 3194], 'start': [3144, 3197], 'codon': [3145, 3198], '(GenBank™': [3146, 3205], 'accession': [3147, 3206], 'BC020227)': [3149], 'does': [3151, 3221, 3855], 'match': [3153, 3223], 'any': [3154, 3224], 'sequence,': [3157, 3226], 'except': [3158], 'pseudogene': [3163], 'FoxO3b': [3164], 'Blast': [3167], 'search': [3168], 'website': [3172], '(www.ncbi.nlm.nih.gov).': [3173], 'sense': [3175, 3231, 3237], '5′-ACUCCGGGUCCAGCUCCAC(dTdT)-3′;': [3176], 'antisense': [3178, 3234, 3241], '5′-GUGGAGCUGGACCCGGAGU(dTdT)-3′.': [3179], '39–57': [3189], 'BimEL': [3203], 'NM_138621).': [3208], 'present': [3212], 'all': [3214, 3367], 'splice': [3218], 'forms,': [3219], 'GenBank™.': [3229], '5′-CAAUUGUCUACCUUCUCGG(dTdT)-3′;': [3232], '5′-CCGAGAAGGUAGACAAUUG(dTdT)-3′;': [3235], '5′-UUCUCCGAACGUGUCACGU(dTdT)-3′;': [3238], '5′-ACGUGACACGUUCGGAGAA(dTdT)-3′.': [3242], 'Induced': [3244], 'Panel': [3249, 3415], 'Carcinoma': [3252, 3418], 'Lines—To': [3254], 'delineate': [3255], 'cancer,': [3264], 'measured': [3287, 3969], 'shown': [3294, 3423, 3986], 'Fig.': [3296, 3988, 4048], '1A': [3297, 4049], 'clearly': [3298, 3990, 4222, 4338], 'extensive': [3303, 4118, 4277], 'heterogeneity': [3304], 'lines.': [3316, 3353, 3597, 3727], 'least': [3318], 'paclitaxel-sensitive': [3319, 4346], 'T47D,': [3325, 3614, 3687, 3757], 'displayed': [3327], 'than': [3334, 3374], '5%.': [3335], 'Intermediate': [3336], '(an': [3338], '10%)': [3344], 'ZR-75-1': [3349, 3623], 'CAL-51': [3351], 'HMT3552,': [3360, 3693, 3713, 3811], '734B,': [3362, 3685, 3715, 3756], 'SKBR-7,': [3365], 'exhibited': [3368], 'increases': [3369], 'greater': [3373], 'identify': [3386], 'differences': [3387], 'apoptotic': [3392, 3399, 4146], 'regulators': [3393], 'could': [3395], 'explain': [3396], 'heterogeneous': [3398], 'response.': [3400], 'Protein': [3402, 4124], 'Expression': [3403, 4125], 'Family': [3406], 'Members': [3407], 'Targets': [3410], 'Is': [3411], 'Heterogeneous': [3412], 'Lines—It': [3420], 'induce': [3432], 'BH3-only': [3435], 'hematopoietic': [3439], 'causing': [3442], 'death': [3444, 4279], 'because': [3504], 'deregulated': [3510], '(26.Page': [3514], 'Jin': [3518], 'Cho': [3520], 'Lilja': [3522], 'Reynolds': [3524], 'R.K.': [3525], '17:': [3532], '23-28PubMed': [3533], '27.Perez-Tenorio': [3536], 'Stal': [3538], 'O.': [3539], 'Br.': [3540], '86:': [3544], '540-545Crossref': [3545], '(360)': [3548], 'subject': [3559], 'inhibitory': [3561], 'PKB,': [3564], 'sought': [3566], 'examine': [3568], 'whether': [3578], 'induced': [3587, 4343], 'pattern': [3600, 4320], 'shows': [3604, 3706, 3991], 'highest': [3608, 3653], '734B': [3612, 3814], 'intermediate': [3616], 'HMT3522': [3621], '(Fig.': [3624, 4250], '1B).': [3625], 'lowest': [3631], 'SKBR-7.': [3637], 'case': [3640], 'form': [3651], '734B.': [3657], 'remaining': [3663, 3725], 'much': [3667, 3699], 'lower.': [3668, 3700], 'heterogeneity,': [3707], 'very': [3719, 4076], 'comparison': [3722], 'equal': [3738], 'loading': [3739], 'gels,': [3742], 'little': [3745], 'variation.': [3746], 'Taken': [3747], 'together,': [3748], 'lesser': [3763, 4334], 'extent,': [3764], 'HMT3552': [3766], 'lines,': [3768], 'correlation': [3772], '-3a,': [3779], 'What': [3795, 4283], 'clear': [3797], 'correlates': [3815], 'Conversely,': [3823], 'T47D': [3831], 'lack': [3838], 'exceptions': [3843], 'expresses': [3849], 'undergo': [3857, 4117], 'readily,': [3859, 3941], 'display': [3865], 'despite': [3870], 'Induces': [3887, 4122], 'Death': [3889], 'Drug-sensitive': [3892, 4133], 'Line,': [3894], 'G2/M': [3896, 4009, 4091, 4103], 'Arrest': [3897], 'Less': [3900], 'Line—To': [3903, 4137], 'investigate': [3904], 'more': [3906], 'detail': [3907], 'chose': [3920], 'perform': [3922], 'further': [3923], 'two': [3926, 3965], 'lines:': [3928], 'underwent': [3939, 4276], 'refractory': [3955], 'cell-cycle': [3960], 'phase': [3961, 4010, 4092, 4104], 'distribution': [3962], 'ethanol-fixed': [3974], 'iodide-stained': [3976], 'fraction': [4004, 4067], 'gradual': [4028], 'dead': [4034], 'dying': [4036], '<2N': [4039, 4066], 'content.': [4041], 'determination': [4044], 'made': [4051], 'staining,': [4055], 'V-positive': [4073], 'similar': [4077], 'would': [4083], 'death.': [4094, 4120], 'contrast,': [4096], 'accumulate': [4100], 'polyploid': [4113], 'do': [4115], 'Increased': [4123], 'Cancer': [4135], 'study': [4138], 'compared': [4156], '75': [4170, 4255, 4326], 'nm.': [4171], 'Whole': [4172], '24,': [4178], '48,': [4179], '72': [4181, 4209], 'previous': [4189], 'experiment': [4190], 'times': [4193], 'when': [4194], 'initiated': [4197], '(24': [4198], 'h)': [4199], '(48': [4207], 'h).': [4210], 'blotting.': [4219], 'phospho-': [4239], '3A).': [4251], 'observable': [4262], 'pronounced': [4270], '(data': [4280], 'shown).': [4282], 'striking': [4286], 'observation': [4289], 'group,': [4330], 'extent.': [4335]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2157633567', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 18}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 24}, {'year': 2019, 'cited_by_count': 27}, {'year': 2018, 'cited_by_count': 15}, {'year': 2017, 'cited_by_count': 24}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 27}, {'year': 2014, 'cited_by_count': 34}, {'year': 2013, 'cited_by_count': 40}, {'year': 2012, 'cited_by_count': 31}], 'updated_date': '2024-12-29T12:27:19.620981', 'created_date': '2016-06-24'}
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