Title: 3D Structural Patterns in Scalable, Elastomeric Scaffolds Guide Engineered Tissue Architecture
Abstract: Advanced MaterialsVolume 25, Issue 32 p. 4459-4465 Communication 3D Structural Patterns in Scalable, Elastomeric Scaffolds Guide Engineered Tissue Architecture† Martin E. Kolewe, Martin E. Kolewe Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USASearch for more papers by this authorHyoungshin Park, Hyoungshin Park Microsystems Development and Microfabrication, Process Engineering Groups, Charles Stark Draper Laboratory, Cambridge, MA 02139, USASearch for more papers by this authorCaprice Gray, Caprice Gray Microsystems Development and Microfabrication, Process Engineering Groups, Charles Stark Draper Laboratory, Cambridge, MA 02139, USASearch for more papers by this authorXiaofeng Ye, Xiaofeng Ye Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USASearch for more papers by this authorRobert Langer, Robert Langer Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USASearch for more papers by this authorLisa E. Freed, Corresponding Author Lisa E. Freed [email protected] [email protected] Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Microsystems Development and Microfabrication, Process Engineering Groups, Charles Stark Draper Laboratory, Cambridge, MA 02139, USAHarvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Search for more papers by this author Martin E. Kolewe, Martin E. Kolewe Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USASearch for more papers by this authorHyoungshin Park, Hyoungshin Park Microsystems Development and Microfabrication, Process Engineering Groups, Charles Stark Draper Laboratory, Cambridge, MA 02139, USASearch for more papers by this authorCaprice Gray, Caprice Gray Microsystems Development and Microfabrication, Process Engineering Groups, Charles Stark Draper Laboratory, Cambridge, MA 02139, USASearch for more papers by this authorXiaofeng Ye, Xiaofeng Ye Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USASearch for more papers by this authorRobert Langer, Robert Langer Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USASearch for more papers by this authorLisa E. Freed, Corresponding Author Lisa E. Freed [email protected] [email protected] Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Microsystems Development and Microfabrication, Process Engineering Groups, Charles Stark Draper Laboratory, Cambridge, MA 02139, USAHarvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Search for more papers by this author First published: 14 June 2013 https://doi.org/10.1002/adma.201301016Citations: 87 † Dedicated to the memory of Officer Sean Collier, for his caring service to the MIT community and for his sacrifice Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fiber orientation in both skeletal and cardiac muscle, enabling scale up of tissue constructs towards clinically relevant dimensions. References 1 R. Langer, J. P. Vacanti, Science 1993, 260, 920. 2 H. Park, C. Cannizzaro, G. Vunjak-Novakovic, R. Langer, C. A. Vacanti, O. C. Farokhzad, Tissue Eng. 2007, 13, 1867. 3 L. E. Freed, G. C. Engelmayr, J. T. Borenstein, F. T. Moutos, F. Guilak, Adv. Mater. 2009, 21, 3410. 4 L. E. Freed, J. C. Marquis, A. Nohria, J. Emmanual, A. G. Mikos, R. Langer, J. Biomed. Mater. Res. 1993, 27, 11. 5 M. Radisic, H. Park, F. Chen, J. E. Salazar-Lazzaro, Y. D. Wang, R. Dennis, R. Langer, L. E. Freed, G. Vunjak-Novakovic, Tissue Eng. 2006, 12, 2077. 6 F. T. Moutos, L. E. Freed, F. Guilak, Nat. Mater. 2007, 6, 162. 7 J. Gao, P. M. Crapo, Y. D. Wang, Tissue Eng. 2006, 12, 917. 8 V. J. Chen, P. X. Ma, Biomaterials 2004, 25, 2065. 9 L. M. Bellan, T. Kniazeva, E. S. Kim, A. A. Epshteyn, D. M. Cropek, R. Langer, J. T. Borenstein, Adv. Healthcare Mater. 2012, 1, 164. 10 L. M. Bellan, M. Pearsall, D. M. Cropek, R. Langer, Adv. Mater. 2012, 24, 5187. 11 W. Wu, R. A. Allen, Y. D. Wang, Nat. Med. 2012, 18, 1148. 12 J. Lee, M. J. Cuddihy, N. A. Kotov, Tissue Eng., Part B 2008, 14, 61. 13 I. J. Legrice, B. H. Smaill, L. Z. Chai, S. G. Edgar, J. B. Gavin, P. J. Hunter, Am. J. Physiol.: Heart Circ. Phys. 1995, 269, H571. 14 A. J. Pope, G. B. Sands, B. H. Smaill, I. J. LeGrice, Am. J. Physiol.: Heart Circ. Phys. 2008, 295, H1243. 15 V. J. Wedeen, D. L. Rosene, R. P. Wang, G. P. Dai, F. Mortazavi, P. Hagmann, J. H. Kaas, W. Y. I. Tseng, Science 2012, 335, 1628. 16 L. L. Y. Chiu, M. Montgomery, Y. Liang, H. J. Liu, M. Radisic, Proc. Natl. Acad. Sci. USA 2012, 109, E3414. 17 H. Naito, I. Melnychenko, M. Didie, K. Schneiderbanger, P. Schubert, S. Rosenkranz, T. Eschenhagen, W. H. Zimmermann, Circulation 2006, 114, I72. 18 A. Khademhosseini, K. Y. Suh, J. M. Yang, G. Eng, J. Yeh, S. Levenberg, R. Langer, Biomaterials 2004, 25, 3583. 19 J. C. Culver, J. C. Hoffmann, R. A. Poche, J. H. Slater, J. L. West, M. E. Dickinson, Adv. Mater. 2012, 24, 2344. 20 Y. A. Du, E. Lo, S. Ali, A. Khademhosseini, Proc. Natl. Acad. Sci. USA 2008, 105, 9522. 21 U. A. Gurkan, Y. Fan, F. Xu, B. Erkmen, E. S. Urkac, G. Parlakgul, J. Bernstein, W. Xing, E. S. Boyden, U. Demirci, Adv. Mater. 2013, 25, 1192. 22 C. Norotte, F. S. Marga, L. E. Niklason, G. Forgacs, Biomaterials 2009, 30, 5910. 23 F. Xu, C. A. M. Wu, V. Rengarajan, T. D. Finley, H. O. Keles, Y. R. Sung, B. Q. Li, U. A. Gurkan, U. Demirci, Adv. Mater. 2011, 23, 4254. 24 D. H. Kim, E. A. Lipke, P. Kim, R. Cheong, S. Thompson, M. Delannoy, K. Y. Suh, L. Tung, A. Levchenko, Proc. Natl. Acad. Sci. USA 2010, 107, 565. 25 B. Y. Zhang, Y. Xiao, A. Hsieh, N. Thavandiran, M. Radisic, Nanotechnology 2011, 22, 10. 26 S. L. Hume, S. M. Hoyt, J. S. Walker, B. V. Sridhar, J. F. Ashley, C. N. Bowman, S. J. Bryant, Acta Biomater. 2012, 8, 2193. 27 A. W. Feinberg, P. W. Alford, H. W. Jin, C. M. Ripplinger, A. A. Werdich, S. P. Sheehy, A. Grosberg, K. K. Parker, Biomaterials 2012, 33, 5732. 28 C. J. Bettinger, B. Orrick, A. Misra, R. Langer, J. T. Borenstein, Biomaterials 2006, 27, 2558. 29 W. N. Bian, N. Bursac, Biomaterials 2009, 30, 1401. 30 G. C. Engelmayr, M. Y. Cheng, C. J. Bettinger, J. T. Borenstein, R. Langer, L. E. Freed, Nat. Mater. 2008, 7, 1003. 31 M. D. Guillemette, H. Park, J. C. Hsiao, S. R. Jain, B. L. Larson, R. Langer, L. E. Freed, Macromol. Biosci. 2010, 10, 1330. 32 F. P. W. Melchels, M. A. N. Domingos, T. J. Klein, J. Malda, P. J. Bartolo, D. W. Hutmacher, Prog. Polymer Sci. 2012, 37, 1079. 33 J. N. Hanson Shepherd, S. T. Parker, R. F. Shepherd, M. U. Gillette, J. A. Lewis, R. G. Nuzzo, Adv. Funct. Mater. 2011, 21, 47. 34 V. Melissinaki, A. A. Gill, I. Ortega, M. Vamvakaki, A. Ranella, J. W. Haycock, C. Fotakis, M. Farsari, F. Claeyssens, Biofabrication 2011, 3, 12. 35 R. A. Neal, A. Jean, H. Park, P. B. Wu, J. Hsiao, G. C. Engelmayr Jr., R. Langer, L. E. Freed, Tissue Eng. 2013, 19, 793. 36 H. Park, B. L. Larson, M. D. Guillemette, S. R. Jain, C. Hua, G. C. Engelmayr, L. E. Freed, Biomaterials 2011, 32, 1856. 37 A. Folch, S. Mezzour, M. Düring, O. Hurtado, M. Toner, R. Müller, Biomed. Microdevices 2000, 2, 207. 38 W. Ryu, S. W. Min, K. E. Hammerick, M. Vyakarnam, R. S. Greco, F. B. Prinz, R. J. Fasching, Biomaterials 2007, 28, 1174. 39 W. Ryu, R. J. Fasching, M. Vyakarnam, R. S. Greco, F. B. Prinz, J. Microelectromech. Syst. 2006, 15, 1457. 40 K. R. King, C. C. J. Wang, M. R. Kaazempur-Mofrad, J. P. Vacanti, J. T. Borenstein, Adv. Mater. 2004, 16, 2007. 41 C. J. Bettinger, E. J. Weinberg, K. M. Kulig, J. P. Vacanti, Y. D. Wang, J. T. Borenstein, R. Langer, Adv. Mater. 2006, 18, 165. 42 T. C. Marentis, J. P. Vacanti, J. C. Hsiao, J. T. Borenstein, J. Microelectromech. Syst. 2009, 18, 531. 43 J. S. Miller, K. R. Stevens, M. T. Yang, B. M. Baker, D. H. T. Nguyen, D. M. Cohen, E. Toro, A. A. Chen, P. A. Galie, X. Yu, R. Chaturvedi, S. N. Bhatia, C. S. Chen, Nat. Mater. 2012, 11, 768. 44 J. U. Knickerbocker, P. S. Andry, B. Dang, R. R. Horton, M. J. Interrante, C. S. Patel, R. J. Polastre, K. Sakuma, R. Sirdeshmukh, E. J. Sprogis, S. M. Sri-Jayantha, A. M. Stephens, A. W. Topol, C. K. Tsang, B. C. Webb, S. L. Wright, IBM J. Res. Dev. 2008, 52, 553. 45 S. F. Al-Sarawi, D. Abbott, P. D. Franzon, IEEE Trans. Compon. Packag. Manuf. Technol., Part B 1998, 21, 2. 46 R. N. Das, F. D. Egitto, J. Lauffer, B. Bonitz, B. Wilson, F. Marconi, M. D. Poliks, V. R. Markovich, in IEEE 62nd Electronic Components and Technology Conf., 2012, p. 1333. 47 M. Radisic, H. Park, T. P. Martens, J. E. Salazar-Lazaro, W. L. Geng, Y. D. Wang, R. Langer, L. E. Freed, G. Vunjak-Novakovic, J. Biomed. Mater. Res., Part A 2008, 86A, 713. 48 G. Gaudesius, M. Miragoli, S. P. Thomas, S. Rohr, Circulation Res. 2003, 93, 421. 49 A. Jean, G. C. Engelmayr, J. Biomech. 2010, 43, 3035. 50 G. M. Fomovsky, J. R. Macadangdang, G. Ailawadi, J. W. Holmes, J. Cardiovasc. Transl. Res. 2011, 4, 82. 51 G. M. Fomovsky, S. A. Clark, K. M. Parker, G. Ailawadi, J. W. Holmes, Circulation: Heart Failure 2012, 5, 515. 52 Y. D. Wang, G. A. Ameer, B. J. Sheppard, R. Langer, Nat. Biotechnol. 2002, 20, 602. 53 M. Radisic, H. Park, H. Shing, T. Consi, F. J. Schoen, R. Langer, L. E. Freed, G. Vunjak-Novakovic, Proc. Natl. Acad. Sci. USA 2004, 101, 18129. 54 C. P. Ng, B. Hinz, M. A. Swartz, J. Cell Sci. 2005, 118, 4731. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. 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