Publication Information

{'id': 'https://openalex.org/W2157200385', 'doi': 'https://doi.org/10.1073/pnas.1501192112', 'title': 'Constraints on the evolution of a <i>doublesex</i> target gene arising from doublesex’s pleiotropic deployment', 'display_name': 'Constraints on the evolution of a <i>doublesex</i> target gene arising from doublesex’s pleiotropic deployment', 'publication_year': 2015, 'publication_date': '2015-02-09', 'ids': {'openalex': 'https://openalex.org/W2157200385', 'doi': 'https://doi.org/10.1073/pnas.1501192112', 'mag': '2157200385', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25675536', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4345571'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1501192112', 'pdf_url': 'https://www.pnas.org/content/pnas/112/8/E852.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.pnas.org/content/pnas/112/8/E852.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5014873915', 'display_name': 'Shengzhan D. Luo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I195573530', 'display_name': 'Janelia Research Campus', 'ror': 'https://ror.org/013sk6x84', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1344073410', 'https://openalex.org/I195573530']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shengzhan D. Luo', 'raw_affiliation_strings': ['Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147'], 'affiliations': [{'raw_affiliation_string': 'Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147', 'institution_ids': ['https://openalex.org/I195573530', 'https://openalex.org/I1344073410']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110110842', 'display_name': 'Bruce S. Baker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I195573530', 'display_name': 'Janelia Research Campus', 'ror': 'https://ror.org/013sk6x84', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1344073410', 'https://openalex.org/I195573530']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bruce S. Baker', 'raw_affiliation_strings': ['Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147'], 'affiliations': [{'raw_affiliation_string': 'Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147', 'institution_ids': ['https://openalex.org/I195573530', 'https://openalex.org/I1344073410']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.832, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.669957, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '112', 'issue': '8', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10423', 'display_name': 'Neurobiology and Insect Physiology Research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10423', 'display_name': 'Neurobiology and Insect Physiology Research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11077', 'display_name': 'Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10174', 'display_name': 'Animal Behavior and Reproduction', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1105', 'display_name': 'Ecology, Evolution, Behavior and Systematics'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/doublesex', 'display_name': 'Doublesex', 'score': 0.99769545}, {'id': 'https://openalex.org/keywords/sexual-dimorphism', 'display_name': 'Sexual dimorphism', 'score': 0.670714}, {'id': 'https://openalex.org/keywords/melanogaster', 'display_name': 'Melanogaster', 'score': 0.4868483}], 'concepts': [{'id': 'https://openalex.org/C2776514529', 'wikidata': 'https://www.wikidata.org/wiki/Q5300147', 'display_name': 'Doublesex', 'level': 5, 'score': 0.99769545}, {'id': 'https://openalex.org/C2780104201', 'wikidata': 'https://www.wikidata.org/wiki/Q130888', 'display_name': 'Drosophila melanogaster', 'level': 3, 'score': 0.7358113}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.71855366}, {'id': 'https://openalex.org/C105083479', 'wikidata': 'https://www.wikidata.org/wiki/Q181497', 'display_name': 'Sexual dimorphism', 'level': 2, 'score': 0.670714}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.58833927}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.5187419}, {'id': 'https://openalex.org/C2776998849', 'wikidata': 'https://www.wikidata.org/wiki/Q3766082', 'display_name': 'Melanogaster', 'level': 4, 'score': 0.4868483}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.44730797}, {'id': 'https://openalex.org/C78458016', 'wikidata': 'https://www.wikidata.org/wiki/Q840400', 'display_name': 'Evolutionary biology', 'level': 1, 'score': 0.41857392}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.40476385}, {'id': 'https://openalex.org/C54458228', 'wikidata': 'https://www.wikidata.org/wiki/Q237218', 'display_name': 'RNA splicing', 'level': 4, 'score': 0.18365967}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D029721', 'descriptor_name': 'Drosophila Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D019143', 'descriptor_name': 'Evolution, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017344', 'descriptor_name': 'Genes, Insect', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D058685', 'descriptor_name': 'Genetic Pleiotropy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012727', 'descriptor_name': 'Sex Characteristics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002299', 'descriptor_name': 'Cardia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002299', 'descriptor_name': 'Cardia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029721', 'descriptor_name': 'Drosophila Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029721', 'descriptor_name': 'Drosophila Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005216', 'descriptor_name': 'Fat Body', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005216', 'descriptor_name': 'Fat Body', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005216', 'descriptor_name': 'Fat Body', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012045', 'descriptor_name': 'Regulatory Sequences, Nucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012045', 'descriptor_name': 'Regulatory Sequences, Nucleic Acid', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013045', 'descriptor_name': 'Species Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1501192112', 'pdf_url': 'https://www.pnas.org/content/pnas/112/8/E852.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4345571', 'pdf_url': 'https://europepmc.org/articles/pmc4345571?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345571', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25675536', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1501192112', 'pdf_url': 'https://www.pnas.org/content/pnas/112/8/E852.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.49, 'id': 'https://metadata.un.org/sdg/5', 'display_name': 'Gender equality'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1482845445', 'https://openalex.org/W1518792202', 'https://openalex.org/W1543392118', 'https://openalex.org/W1550326631', 'https://openalex.org/W1605558698', 'https://openalex.org/W1861633139', 'https://openalex.org/W1916841507', 'https://openalex.org/W1941158163', 'https://openalex.org/W1965383677', 'https://openalex.org/W1968217820', 'https://openalex.org/W1968224856', 'https://openalex.org/W1993827187', 'https://openalex.org/W1995070274', 'https://openalex.org/W1996617149', 'https://openalex.org/W2004613304', 'https://openalex.org/W2013612148', 'https://openalex.org/W2031611773', 'https://openalex.org/W2050609151', 'https://openalex.org/W2058735127', 'https://openalex.org/W2062150244', 'https://openalex.org/W2063353051', 'https://openalex.org/W2068771737', 'https://openalex.org/W2068784916', 'https://openalex.org/W2072718843', 'https://openalex.org/W2091161122', 'https://openalex.org/W2095517059', 'https://openalex.org/W2096569072', 'https://openalex.org/W2101965470', 'https://openalex.org/W2104738805', 'https://openalex.org/W2106255860', 'https://openalex.org/W2113559961', 'https://openalex.org/W2113793056', 'https://openalex.org/W2117325570', 'https://openalex.org/W2122326316', 'https://openalex.org/W2125126554', 'https://openalex.org/W2133147430', 'https://openalex.org/W2136119836', 'https://openalex.org/W2136348345', 'https://openalex.org/W2141953863', 'https://openalex.org/W2152660732', 'https://openalex.org/W2153718995', 'https://openalex.org/W2157159187', 'https://openalex.org/W2161247951', 'https://openalex.org/W2161899020', 'https://openalex.org/W2164403510', 'https://openalex.org/W2170657163', 'https://openalex.org/W2171193618', 'https://openalex.org/W3028418616', 'https://openalex.org/W318338043', 'https://openalex.org/W333721929', 'https://openalex.org/W4251678559'], 'related_works': ['https://openalex.org/W4230768823', 'https://openalex.org/W3217674162', 'https://openalex.org/W2503941435', 'https://openalex.org/W2429278941', 'https://openalex.org/W2086842568', 'https://openalex.org/W2075087776', 'https://openalex.org/W2014093629', 'https://openalex.org/W2013474102', 'https://openalex.org/W1972794703', 'https://openalex.org/W1945867075'], 'abstract_inverted_index': {'"Regulatory': [0], 'evolution,"': [1], 'that': [2, 122, 183], 'is,': [3], 'changes': [4, 11, 18, 27, 75, 86], 'in': [5, 68, 72, 76, 132, 136, 151, 162, 168, 192, 202, 211, 245], 'a': [6, 38, 83, 103, 147, 236], "gene's": [7], 'expression': [8, 55, 113], 'pattern': [9], 'through': [10, 146], 'at': [12, 19, 87], 'its': [13, 115], 'regulatory': [14, 89, 154], 'sequence,': [15], 'rather': [16], 'than': [17], 'the': [20, 24, 29, 51, 58, 88, 92, 98, 128, 133, 141, 152, 157, 163, 171, 193, 203, 217, 224, 227, 240], 'coding': [21], 'sequence': [22, 90], 'of': [23, 28, 47, 53, 85, 91, 140, 195, 199, 219, 226], 'gene': [25, 54], 'or': [26, 187], 'upstream': [30], 'transcription': [31, 65, 130, 161, 201], 'factors,': [32], 'has': [33, 165], 'been': [34], 'increasingly': [35], 'recognized': [36], 'as': [37], 'pervasive': [39], 'evolution': [40, 116], 'mechanism.': [41], 'Many': [42], 'somatic': [43], 'sexually': [44, 78, 111, 185, 206, 209], 'dimorphic': [45, 79, 112, 188, 207], 'features': [46, 80], 'Drosophila': [48], 'melanogaster': [49, 158], 'are': [50, 81, 117, 214], 'results': [52], 'regulated': [56], 'by': [57, 216, 253], 'doublesex': [59], '(dsx)': [60], 'gene,': [61, 102], 'which': [62], 'encodes': [63], 'sex-specific': [64], 'factors': [66], '(DSX(F)': [67], 'females': [69], 'and': [70, 114, 135, 181], 'DSX(M)': [71], 'males).': [73], 'Rapid': [74], 'such': [77], 'likely': [82, 104], 'result': [84], 'target': [93], 'genes.': [94], 'We': [95, 120, 175], 'focused': [96], 'on': [97, 235], 'Flavin-containing': [99], 'monooxygenase-2': [100], '(Fmo-2)': [101], 'direct': [105, 184], 'dsx': [106, 123], 'target,': [107], 'to': [108, 126, 170, 208, 242], 'elucidate': [109], 'how': [110], 'brought': [118], 'about.': [119], 'found': [121], 'is': [124], 'deployed': [125], 'regulate': [127], 'Fmo-2': [129, 153, 160, 189, 200], 'both': [131], 'midgut': [134, 164, 204], 'fat': [137], 'body': [138], 'cells': [139], 'spermatheca': [142], '(a': [143], 'female-specific': [144], 'tissue),': [145], 'canonical': [148, 228], 'DSX-binding': [149, 229], 'site': [150], 'sequence.': [155], 'In': [156], 'group,': [159], 'evolved': [166], 'rapidly,': [167], 'contrast': [169], 'conserved': [172], 'spermathecal': [173], 'transcription.': [174], 'identified': [176], 'two': [177], 'cis-regulatory': [178], 'modules': [179], '(CRM-p': [180], 'CRM-d)': [182], 'monomorphic': [186, 210], 'transcription,': [190], 'respectively,': [191], 'midguts': [194], 'these': [196], 'species.': [197], 'Changes': [198], 'from': [205], 'some': [212], 'species': [213], 'caused': [215], 'loss': [218, 225], 'CRM-d': [220], 'function,': [221], 'but': [222], 'not': [223], 'site.': [230], 'Thus,': [231], 'conferring': [232], 'transcriptional': [233], 'regulation': [234, 241], 'CRM': [237], 'level': [238], 'allows': [239], 'evolve': [243], 'rapidly': [244], 'one': [246], 'tissue': [247], 'while': [248], 'evading': [249], 'evolutionary': [250], 'constraints': [251], 'posed': [252], 'other': [254], 'tissues.': [255]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2157200385', 'counts_by_year': [{'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-17T17:06:36.036363', 'created_date': '2016-06-24'}