Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2157172418', 'doi': 'https://doi.org/10.1016/s0002-9440(10)64959-0', 'title': 'Galectin-3 Induces Endothelial Cell Morphogenesis and Angiogenesis', 'display_name': 'Galectin-3 Induces Endothelial Cell Morphogenesis and Angiogenesis', 'publication_year': 2000, 'publication_date': '2000-03-01', 'ids': {'openalex': 'https://openalex.org/W2157172418', 'doi': 'https://doi.org/10.1016/s0002-9440(10)64959-0', 'mag': '2157172418', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10702407', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1876842'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0002-9440(10)64959-0', 'pdf_url': 'http://ajp.amjpathol.org/article/S0002944010649590/pdf', 'source': {'id': 'https://openalex.org/S145577119', 'display_name': 'American Journal Of Pathology', 'issn_l': '0002-9440', 'issn': ['0002-9440', '1525-2191'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://ajp.amjpathol.org/article/S0002944010649590/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5055334649', 'display_name': 'Pratima Nangia‐Makker', 'orcid': 'https://orcid.org/0000-0002-1917-169X'}, 'institutions': [{'id': 'https://openalex.org/I4210090317', 'display_name': 'The Barbara Ann Karmanos Cancer Institute', 'ror': 'https://ror.org/00ee40h97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2800590384', 'https://openalex.org/I4210090317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pratima Nangia-Makker', 'raw_affiliation_strings': ['Department of Tumor Progression, Karmanos Cancer Institute, Detroit, Michigan'], 'affiliations': [{'raw_affiliation_string': 'Department of Tumor Progression, Karmanos Cancer Institute, Detroit, Michigan', 'institution_ids': ['https://openalex.org/I4210090317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038005961', 'display_name': 'Yuichiro Honjo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210090317', 'display_name': 'The Barbara Ann Karmanos Cancer Institute', 'ror': 'https://ror.org/00ee40h97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2800590384', 'https://openalex.org/I4210090317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yuichiro Honjo', 'raw_affiliation_strings': ['Department of Tumor Progression, Karmanos Cancer Institute, Detroit, Michigan'], 'affiliations': [{'raw_affiliation_string': 'Department of Tumor Progression, Karmanos Cancer Institute, Detroit, Michigan', 'institution_ids': ['https://openalex.org/I4210090317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032207124', 'display_name': 'Rebecca Sarvis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210090317', 'display_name': 'The Barbara Ann Karmanos Cancer Institute', 'ror': 'https://ror.org/00ee40h97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2800590384', 'https://openalex.org/I4210090317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rebecca Sarvis', 'raw_affiliation_strings': ['Department of Tumor Progression, Karmanos Cancer Institute, Detroit, Michigan'], 'affiliations': [{'raw_affiliation_string': 'Department of Tumor Progression, Karmanos Cancer Institute, Detroit, Michigan', 'institution_ids': ['https://openalex.org/I4210090317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016843414', 'display_name': 'Shiro Akahani', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210125438', 'display_name': 'Osakakita Teishin Hospital', 'ror': 'https://ror.org/02w7n8v98', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210125438']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shiro Akahani', 'raw_affiliation_strings': ['Department of Otolaryngology, Osaka Teishin Hospital, Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Otolaryngology, Osaka Teishin Hospital, Osaka, Japan', 'institution_ids': ['https://openalex.org/I4210125438']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032550342', 'display_name': 'Victor Hogan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210090317', 'display_name': 'The Barbara Ann Karmanos Cancer Institute', 'ror': 'https://ror.org/00ee40h97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2800590384', 'https://openalex.org/I4210090317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Victor Hogan', 'raw_affiliation_strings': ['Department of Tumor Progression, Karmanos Cancer Institute, Detroit, Michigan'], 'affiliations': [{'raw_affiliation_string': 'Department of Tumor Progression, Karmanos Cancer Institute, Detroit, Michigan', 'institution_ids': ['https://openalex.org/I4210090317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087520734', 'display_name': 'Kenneth J. Pienta', 'orcid': 'https://orcid.org/0000-0002-4138-2186'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kenneth J. Pienta', 'raw_affiliation_strings': ['Division of Internal Medicine, University of Michigan, Ann Arbor, Michigan'], 'affiliations': [{'raw_affiliation_string': 'Division of Internal Medicine, University of Michigan, Ann Arbor, Michigan', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010903945', 'display_name': 'Avraham Raz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}, {'id': 'https://openalex.org/I4210090317', 'display_name': 'The Barbara Ann Karmanos Cancer Institute', 'ror': 'https://ror.org/00ee40h97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2800590384', 'https://openalex.org/I4210090317']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Avraham Raz', 'raw_affiliation_strings': ['Department of Pathology and Radiation Oncology, Wayne State University, Detroit, Michigan', 'Department of Tumor Progression, Karmanos Cancer Institute, Detroit, Michigan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Radiation Oncology, Wayne State University, Detroit, Michigan', 'institution_ids': ['https://openalex.org/I185443292']}, {'raw_affiliation_string': 'Department of Tumor Progression, Karmanos Cancer Institute, Detroit, Michigan', 'institution_ids': ['https://openalex.org/I4210090317']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5010903945'], 'corresponding_institution_ids': ['https://openalex.org/I185443292', 'https://openalex.org/I4210090317'], 'apc_list': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'apc_paid': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'fwci': 5.036, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 437, 'citation_normalized_percentile': {'value': 0.999861, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '156', 'issue': '3', 'first_page': '899', 'last_page': '909'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12387', 'display_name': 'Role of Galectins in Immunity and Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12387', 'display_name': 'Role of Galectins in Immunity and Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation in Health and Disease', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt Signaling in Development and Disease', 'score': 0.9791, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/angiogenesis', 'display_name': 'Angiogenesis', 'score': 0.475065}, {'id': 'https://openalex.org/keywords/galectin-3', 'display_name': 'Galectin-3', 'score': 0.46075684}, {'id': 'https://openalex.org/keywords/galectin', 'display_name': 'Galectin', 'score': 0.4281122}], 'concepts': [{'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.8239258}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6206036}, {'id': 'https://openalex.org/C2777834122', 'wikidata': 'https://www.wikidata.org/wiki/Q5939177', 'display_name': 'Human umbilical vein endothelial cell', 'level': 4, 'score': 0.5889351}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5863068}, {'id': 'https://openalex.org/C123012128', 'wikidata': 'https://www.wikidata.org/wiki/Q5376430', 'display_name': 'Endothelial stem cell', 'level': 3, 'score': 0.5860574}, {'id': 'https://openalex.org/C2778271429', 'wikidata': 'https://www.wikidata.org/wiki/Q1281049', 'display_name': 'Neovascularization', 'level': 3, 'score': 0.49241722}, {'id': 'https://openalex.org/C40692019', 'wikidata': 'https://www.wikidata.org/wiki/Q815547', 'display_name': 'Morphogenesis', 'level': 3, 'score': 0.4905607}, {'id': 'https://openalex.org/C2776336362', 'wikidata': 'https://www.wikidata.org/wiki/Q18028529', 'display_name': 'Galectin-3', 'level': 2, 'score': 0.46075684}, {'id': 'https://openalex.org/C156293190', 'wikidata': 'https://www.wikidata.org/wiki/Q83138026', 'display_name': 'Galectin', 'level': 2, 'score': 0.4281122}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.32489336}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.20077339}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12388438}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.10600945}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000943', 'descriptor_name': 'Antigens, Differentiation', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002633', 'descriptor_name': 'Chemotaxis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': 'Q000098', 'qualifier_name': 'blood supply', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000943', 'descriptor_name': 'Antigens, Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000943', 'descriptor_name': 'Antigens, Differentiation', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002196', 'descriptor_name': 'Capillaries', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002196', 'descriptor_name': 'Capillaries', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D002633', 'descriptor_name': 'Chemotaxis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017077', 'descriptor_name': 'Culture Media, Conditioned', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017077', 'descriptor_name': 'Culture Media, Conditioned', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037502', 'descriptor_name': 'Galectin 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007124', 'descriptor_name': 'Immunoenzyme Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014471', 'descriptor_name': 'Umbilical Veins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014471', 'descriptor_name': 'Umbilical Veins', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0002-9440(10)64959-0', 'pdf_url': 'http://ajp.amjpathol.org/article/S0002944010649590/pdf', 'source': {'id': 'https://openalex.org/S145577119', 'display_name': 'American Journal Of Pathology', 'issn_l': '0002-9440', 'issn': ['0002-9440', '1525-2191'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1876842', 'pdf_url': 'https://europepmc.org/articles/pmc1876842?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876842', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10702407', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0002-9440(10)64959-0', 'pdf_url': 'http://ajp.amjpathol.org/article/S0002944010649590/pdf', 'source': {'id': 'https://openalex.org/S145577119', 'display_name': 'American Journal Of Pathology', 'issn_l': '0002-9440', 'issn': ['0002-9440', '1525-2191'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 67, 'referenced_works': ['https://openalex.org/W151723881', 'https://openalex.org/W1520800891', 'https://openalex.org/W1531209670', 'https://openalex.org/W1549447766', 'https://openalex.org/W1577717236', 'https://openalex.org/W1636670860', 'https://openalex.org/W1638424324', 'https://openalex.org/W1722659238', 'https://openalex.org/W1746431788', 'https://openalex.org/W19052207', 'https://openalex.org/W1965111440', 'https://openalex.org/W1971377557', 'https://openalex.org/W1983649348', 'https://openalex.org/W1987059068', 'https://openalex.org/W1989467168', 'https://openalex.org/W1994360534', 'https://openalex.org/W1996657758', 'https://openalex.org/W1997305264', 'https://openalex.org/W2000000541', 'https://openalex.org/W2005063423', 'https://openalex.org/W2006458534', 'https://openalex.org/W2010028060', 'https://openalex.org/W2011083738', 'https://openalex.org/W2011467997', 'https://openalex.org/W2014065989', 'https://openalex.org/W2016479978', 'https://openalex.org/W2035819392', 'https://openalex.org/W2039920167', 'https://openalex.org/W2041856244', 'https://openalex.org/W2043558120', 'https://openalex.org/W2050969749', 'https://openalex.org/W2059322719', 'https://openalex.org/W2063734246', 'https://openalex.org/W2067791064', 'https://openalex.org/W2072446438', 'https://openalex.org/W2072928113', 'https://openalex.org/W2079394569', 'https://openalex.org/W2086011121', 'https://openalex.org/W2086865843', 'https://openalex.org/W2090475723', 'https://openalex.org/W2099543104', 'https://openalex.org/W2101133312', 'https://openalex.org/W2102275131', 'https://openalex.org/W2114072364', 'https://openalex.org/W2115141431', 'https://openalex.org/W2117832286', 'https://openalex.org/W2125038571', 'https://openalex.org/W2128495342', 'https://openalex.org/W2128749862', 'https://openalex.org/W2131798870', 'https://openalex.org/W2134835093', 'https://openalex.org/W2136989771', 'https://openalex.org/W2140410752', 'https://openalex.org/W2180209555', 'https://openalex.org/W2232660545', 'https://openalex.org/W2400609710', 'https://openalex.org/W2402784056', 'https://openalex.org/W2404569670', 'https://openalex.org/W2405576086', 'https://openalex.org/W2407015583', 'https://openalex.org/W2414544389', 'https://openalex.org/W2417788395', 'https://openalex.org/W31979510', 'https://openalex.org/W4238292561', 'https://openalex.org/W4252714519', 'https://openalex.org/W4255042798', 'https://openalex.org/W7317053'], 'related_works': ['https://openalex.org/W55782026', 'https://openalex.org/W4300349701', 'https://openalex.org/W4235086811', 'https://openalex.org/W3173627430', 'https://openalex.org/W3030375631', 'https://openalex.org/W2972571810', 'https://openalex.org/W2382233096', 'https://openalex.org/W2119342878', 'https://openalex.org/W2043719770', 'https://openalex.org/W1836000002'], 'abstract_inverted_index': {'Increasing': [0], 'evidence': [1], 'suggests': [2], 'that': [3, 109, 147], 'carbohydrate-binding': [4, 57], 'proteins': [5], 'play': [6], 'an': [7], 'essential': [8], 'role': [9, 38], 'in': [10, 21, 41, 92], 'tumor': [11, 94], 'growth': [12], 'and': [13, 27, 53, 64, 70, 113, 115, 124, 142, 163], 'metastasis.': [14], 'However,': [15], 'conflicting': [16], 'results': [17], 'on': [18], 'their': [19], 'function': [20], 'the': [22, 37, 42, 78, 161], 'regulation': [23, 43], 'of': [24, 39, 44, 120, 165], 'cell': [25, 49, 74, 104, 129, 149], 'proliferation': [26], 'differentiation': [28, 162], 'during': [29], 'angiogenesis': [30, 125, 164], 'have': [31, 35], 'been': [32], 'reported.': [33], 'We': [34], 'examined': [36], 'galectin-3': [40, 85, 110], 'human': [45], 'umbilical': [46], 'vein': [47], 'endothelial': [48, 103, 148, 166], 'proliferation,': [50], 'differentiation,': [51], 'migration,': [52], 'neovascularization.': [54], 'Galectin-3,': [55], 'a': [56, 132, 156], 'protein,': [58], 'with': [59, 96], 'specificity': [60], 'for': [61], 'type': [62], '1': [63], '11': [65], 'ABH': [66], 'blood': [67], 'group': [68], 'epitopes': [69], 'polylactosamine': [71], 'glycan': [72], 'containing': [73], 'surface': [75, 150], 'glycoproteins,': [76], 'is': [77, 131, 137], 'major': [79], 'nonintegrin': [80], 'cellular': [81], 'laminin-binding': [82], 'protein.': [83], 'Because': [84], 'expression': [86], 'was': [87], 'shown': [88], 'to': [89, 160], 'be': [90], 'associated': [91], 'some': [93], 'systems': [95], 'metastasis,': [97], 'we': [98, 107], 'questioned': [99], 'whether': [100], 'it': [101, 136], 'induces': [102], 'morphogenesis.': [105], 'Here': [106], 'show': [108], 'affects': [111], 'chemotaxis': [112], 'morphology': [114], 'stimulates': [116], 'capillary': [117], 'tube': [118], 'formation': [119], 'HUV-EC-C': [121], '<i>in': [122, 126], 'vitro</i>': [123], 'vivo</i>.': [127], 'Endothelial': [128], 'morphogenesis': [130], 'carbohydrate-dependent': [133], 'process,': [134], 'as': [135], 'neutralized': [138], 'by': [139], 'specific': [140], 'sugars': [141], 'antibodies.': [143], 'These': [144], 'findings': [145], 'demonstrate': [146], 'carbohydrate': [151], 'recognition': [152], 'event(s)': [153], 'can': [154], 'induce': [155], 'signaling': [157], 'cascade': [158], 'leading': [159], 'cells.': [167]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2157172418', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 21}, {'year': 2020, 'cited_by_count': 20}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 24}, {'year': 2017, 'cited_by_count': 23}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 20}, {'year': 2014, 'cited_by_count': 34}, {'year': 2013, 'cited_by_count': 24}, {'year': 2012, 'cited_by_count': 28}], 'updated_date': '2024-09-01T04:20:50.440567', 'created_date': '2016-06-24'}