Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2157109399', 'doi': 'https://doi.org/10.1002/(sici)1097-4652(200004)183:1<1::aid-jcp1>3.0.co;2-j', 'title': 'Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis', 'display_name': 'Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis', 'publication_year': 2000, 'publication_date': '2000-04-01', 'ids': {'openalex': 'https://openalex.org/W2157109399', 'doi': 'https://doi.org/10.1002/(sici)1097-4652(200004)183:1<1::aid-jcp1>3.0.co;2-j', 'mag': '2157109399', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10699960', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4144680'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-4652(200004)183:1<1::aid-jcp1>3.0.co;2-j', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-4652%28200004%29183%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-J', 'source': {'id': 'https://openalex.org/S43643205', 'display_name': 'Journal of Cellular Physiology', 'issn_l': '0021-9541', 'issn': ['0021-9541', '1097-4652'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-4652%28200004%29183%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-J', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054009976', 'display_name': 'Adda Grimberg', 'orcid': 'https://orcid.org/0000-0002-1523-1536'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Adda Grimberg', 'raw_affiliation_strings': ['Division of Pediatric Endocrinology, University of Pennsylvania, Philadelphia, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Division of Pediatric Endocrinology, University of Pennsylvania, Philadelphia, Pennsylvania', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5020824287', 'display_name': 'Pinchas Cohen', 'orcid': 'https://orcid.org/0000-0002-0035-8366'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Pinchas Cohen', 'raw_affiliation_strings': ['Division of Pediatric Endocrinology, UCLA, Los Angeles, California'], 'affiliations': [{'raw_affiliation_string': 'Division of Pediatric Endocrinology, UCLA, Los Angeles, California', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5020824287'], 'corresponding_institution_ids': [], 'apc_list': {'value': 4940, 'currency': 'USD', 'value_usd': 4940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 8.983, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 511, 'citation_normalized_percentile': {'value': 0.997442, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '183', 'issue': '1', 'first_page': '1', 'last_page': '9'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11339', 'display_name': 'Metabolism, Diabetes, and Cancer', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9887, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/intracrine', 'display_name': 'Intracrine', 'score': 0.59180456}], 'concepts': [{'id': 'https://openalex.org/C128240485', 'wikidata': 'https://www.wikidata.org/wiki/Q786998', 'display_name': 'Autocrine signalling', 'level': 3, 'score': 0.7926537}, {'id': 'https://openalex.org/C7876069', 'wikidata': 'https://www.wikidata.org/wiki/Q14873666', 'display_name': 'Paracrine signalling', 'level': 3, 'score': 0.7708565}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6286581}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.61728984}, {'id': 'https://openalex.org/C63263939', 'wikidata': 'https://www.wikidata.org/wiki/Q3153691', 'display_name': 'Intracrine', 'level': 4, 'score': 0.59180456}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5761382}, {'id': 'https://openalex.org/C2780689927', 'wikidata': 'https://www.wikidata.org/wiki/Q24766801', 'display_name': 'Insulin-like growth factor', 'level': 4, 'score': 0.57253444}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5309626}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.49682882}, {'id': 'https://openalex.org/C2780378035', 'wikidata': 'https://www.wikidata.org/wiki/Q17143674', 'display_name': 'Insulin-like growth factor-binding protein', 'level': 5, 'score': 0.4881757}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.4394586}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.43050343}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.376766}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3370354}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.10990667}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.10868436}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.10168591}], 'mesh': [{'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D018969', 'descriptor_name': 'Insulin-Like Growth Factor Binding Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D007334', 'descriptor_name': 'Insulin-Like Growth Factor I', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D017526', 'descriptor_name': 'Receptor, IGF Type 1', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018972', 'descriptor_name': 'Insulin-Like Growth Factor Binding Protein 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018972', 'descriptor_name': 'Insulin-Like Growth Factor Binding Protein 3', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D018969', 'descriptor_name': 'Insulin-Like Growth Factor Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007334', 'descriptor_name': 'Insulin-Like Growth Factor I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D017526', 'descriptor_name': 'Receptor, IGF Type 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-4652(200004)183:1<1::aid-jcp1>3.0.co;2-j', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-4652%28200004%29183%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-J', 'source': {'id': 'https://openalex.org/S43643205', 'display_name': 'Journal of Cellular Physiology', 'issn_l': '0021-9541', 'issn': ['0021-9541', '1097-4652'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4144680', 'pdf_url': 'https://europepmc.org/articles/pmc4144680?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144680', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10699960', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/(sici)1097-4652(200004)183:1<1::aid-jcp1>3.0.co;2-j', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-4652%28200004%29183%3A1%3C1%3A%3AAID-JCP1%3E3.0.CO%3B2-J', 'source': {'id': 'https://openalex.org/S43643205', 'display_name': 'Journal of Cellular Physiology', 'issn_l': '0021-9541', 'issn': ['0021-9541', '1097-4652'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.8}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 123, 'referenced_works': ['https://openalex.org/W106042170', 'https://openalex.org/W1481362782', 'https://openalex.org/W1482206857', 'https://openalex.org/W1488424161', 'https://openalex.org/W1511750039', 'https://openalex.org/W1562667342', 'https://openalex.org/W1569741533', 'https://openalex.org/W1587655394', 'https://openalex.org/W1595424043', 'https://openalex.org/W1595825159', 'https://openalex.org/W1863595524', 'https://openalex.org/W1931843124', 'https://openalex.org/W1966051337', 'https://openalex.org/W1970373283', 'https://openalex.org/W1972454974', 'https://openalex.org/W1974033855', 'https://openalex.org/W1976102374', 'https://openalex.org/W1976910992', 'https://openalex.org/W1977236952', 'https://openalex.org/W1979144340', 'https://openalex.org/W1984202709', 'https://openalex.org/W1986819031', 'https://openalex.org/W1987801827', 'https://openalex.org/W1989384369', 'https://openalex.org/W1991414708', 'https://openalex.org/W1993535707', 'https://openalex.org/W1993672117', 'https://openalex.org/W1995765044', 'https://openalex.org/W1998109631', 'https://openalex.org/W1999920704', 'https://openalex.org/W2001117441', 'https://openalex.org/W2003917862', 'https://openalex.org/W2007244371', 'https://openalex.org/W2007324164', 'https://openalex.org/W2008394180', 'https://openalex.org/W2010260719', 'https://openalex.org/W2012940389', 'https://openalex.org/W2016189250', 'https://openalex.org/W2016557888', 'https://openalex.org/W2017124406', 'https://openalex.org/W2017546470', 'https://openalex.org/W2017949036', 'https://openalex.org/W2018723236', 'https://openalex.org/W2018824000', 'https://openalex.org/W2019909983', 'https://openalex.org/W2020636054', 'https://openalex.org/W2023343511', 'https://openalex.org/W2027066393', 'https://openalex.org/W2028771082', 'https://openalex.org/W2029098538', 'https://openalex.org/W2029363714', 'https://openalex.org/W2030981193', 'https://openalex.org/W2031169955', 'https://openalex.org/W2034357726', 'https://openalex.org/W2037922730', 'https://openalex.org/W2041542350', 'https://openalex.org/W2043498363', 'https://openalex.org/W2044313783', 'https://openalex.org/W2046453156', 'https://openalex.org/W2052914368', 'https://openalex.org/W2053099348', 'https://openalex.org/W2053252897', 'https://openalex.org/W2055319820', 'https://openalex.org/W2058703679', 'https://openalex.org/W2059795126', 'https://openalex.org/W2062334993', 'https://openalex.org/W2063745259', 'https://openalex.org/W2067197849', 'https://openalex.org/W2067928197', 'https://openalex.org/W2068776651', 'https://openalex.org/W2069408483', 'https://openalex.org/W2069593461', 'https://openalex.org/W2070001236', 'https://openalex.org/W2070634428', 'https://openalex.org/W2077956417', 'https://openalex.org/W2087433881', 'https://openalex.org/W2089335503', 'https://openalex.org/W2090855543', 'https://openalex.org/W2091543872', 'https://openalex.org/W2094584477', 'https://openalex.org/W2095306595', 'https://openalex.org/W2096048303', 'https://openalex.org/W2098547168', 'https://openalex.org/W2099307235', 'https://openalex.org/W2100390815', 'https://openalex.org/W2102182340', 'https://openalex.org/W2102305832', 'https://openalex.org/W2103340147', 'https://openalex.org/W2106781900', 'https://openalex.org/W2107889255', 'https://openalex.org/W2113402231', 'https://openalex.org/W2126484796', 'https://openalex.org/W2127526484', 'https://openalex.org/W2131354148', 'https://openalex.org/W2131555068', 'https://openalex.org/W2133725782', 'https://openalex.org/W2134886965', 'https://openalex.org/W2140491527', 'https://openalex.org/W2140884727', 'https://openalex.org/W2141195019', 'https://openalex.org/W2146502106', 'https://openalex.org/W2150081825', 'https://openalex.org/W2151085515', 'https://openalex.org/W2153257246', 'https://openalex.org/W2153545176', 'https://openalex.org/W2154802841', 'https://openalex.org/W2159318197', 'https://openalex.org/W2160619015', 'https://openalex.org/W2160864550', 'https://openalex.org/W2162601547', 'https://openalex.org/W2163344674', 'https://openalex.org/W2168558729', 'https://openalex.org/W2169995876', 'https://openalex.org/W2170823338', 'https://openalex.org/W2269126641', 'https://openalex.org/W2331691040', 'https://openalex.org/W2403015394', 'https://openalex.org/W2403438648', 'https://openalex.org/W2416857695', 'https://openalex.org/W2431026489', 'https://openalex.org/W317330932', 'https://openalex.org/W4301428904', 'https://openalex.org/W650008823'], 'related_works': ['https://openalex.org/W3213499325', 'https://openalex.org/W3004047898', 'https://openalex.org/W2367035282', 'https://openalex.org/W2122965245', 'https://openalex.org/W2091727603', 'https://openalex.org/W2085869617', 'https://openalex.org/W2015867957', 'https://openalex.org/W1996832816', 'https://openalex.org/W1975672764', 'https://openalex.org/W1965723545'], 'abstract_inverted_index': {'Interest': [0], 'in': [1, 11, 32, 41, 143, 168, 178, 183], 'the': [2, 5, 21, 37, 42, 71, 81, 92, 97, 159, 172], 'role': [3], 'of': [4, 23, 36, 60, 86, 162, 171], 'insulin-like': [6, 26, 98], 'growth': [7, 12, 27, 99, 114], 'factor': [8, 28], '(IGF)': [9], 'axis': [10, 174], 'control': [13], 'and': [14, 49, 57, 63, 130, 146, 165, 181], 'carcinogenesis': [15], 'has': [16], 'recently': [17], 'been': [18, 176], 'increased': [19], 'by': [20, 96, 116, 138, 154], 'finding': [22], 'elevated': [24], 'serum': [25], 'I': [29], '(IGF-I)': [30], 'levels': [31], 'association': [33, 126], 'with': [34, 91], 'three': [35], 'most': [38], 'prevalent': [39], 'cancers': [40], 'United': [43], 'States:': [44], 'prostate': [45], 'cancer,': [46, 48], 'colorectal': [47], 'lung': [50], 'cancer.': [51], 'IGFs': [52, 164], 'serve': [53], 'as': [54], 'endocrine,': [55], 'autocrine,': [56], 'paracrine': [58], 'stimulators': [59], 'mitogenesis,': [61], 'survival,': [62], 'cellular': [64], 'transformation.': [65], 'These': [66], 'actions': [67], 'are': [68], 'mediated': [69], 'through': [70, 122], 'type': [72], '1': [73], 'IGF-receptor': [74], '(IGF-1R),': [75], 'a': [76], 'tyrosine': [77], 'kinase': [78], 'that': [79], 'resembles': [80], 'insulin': [82], 'receptor.': [83], 'The': [84], 'availability': [85], 'free': [87], 'IGF': [88, 173], 'for': [89], 'interaction': [90], 'IGF-1R': [93], 'is': [94, 118, 136, 151], 'modulated': [95], 'factor-binding': [100], 'proteins': [101, 127], '(IGFBPs).': [102], 'IGFBPs,': [103, 163], 'especially': [104], 'IGFBP-3,': [105], 'also': [106, 152], 'have': [107, 175], 'IGF-independent': [108, 113], 'effects': [109], 'on': [110], 'cell': [111, 124, 140, 185], 'growth.': [112], 'inhibition': [115], 'IGFBP-3': [117], 'believed': [119], 'to': [120], 'occur': [121], 'IGFBP-3-specific': [123], 'surface': [125], 'or': [128], 'receptors': [129], 'involves': [131], 'nuclear': [132], 'translocation.': [133], 'IGFBP-3-mediated': [134], 'apoptosis': [135], 'controlled': [137], 'numerous': [139], 'cycle': [141], 'regulators': [142], 'both': [144], 'normal': [145], 'disease': [147], 'processes.': [148], 'IGFBP': [149, 155], 'activity': [150], 'regulated': [153], 'proteases,': [156], 'which': [157], 'affect': [158], 'relative': [160], 'affinities': [161], 'IGF-1R.': [166], 'Perturbations': [167], 'each': [169], 'level': [170], 'implicated': [177], 'cancer': [179], 'formation': [180], 'progression': [182], 'various': [184], 'types.': [186], 'J.': [187], 'Cell.': [188], 'Physiol.': [189], '183:1–9,': [190], '2000.': [191], '©': [192], '2000': [193], 'Wiley-Liss,': [194], 'Inc.': [195]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2157109399', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 12}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 25}, {'year': 2012, 'cited_by_count': 25}], 'updated_date': '2025-01-04T21:50:29.410511', 'created_date': '2016-06-24'}