Publication Information

{'id': 'https://openalex.org/W2156829110', 'doi': 'https://doi.org/10.2174/0929867033457304', 'title': 'Aldose Reductase Inhibitors from the Nature', 'display_name': 'Aldose Reductase Inhibitors from the Nature', 'publication_year': 2003, 'publication_date': '2003-08-01', 'ids': {'openalex': 'https://openalex.org/W2156829110', 'doi': 'https://doi.org/10.2174/0929867033457304', 'mag': '2156829110', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12871134'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/0929867033457304', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S33159018', 'display_name': 'Current Medicinal Chemistry', 'issn_l': '0929-8673', 'issn': ['0929-8673', '1875-533X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111001213', 'display_name': 'K. Kawanishi', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'K. Kawanishi', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029098844', 'display_name': 'Hirotsugu Ueda', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'H. Ueda', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5082325000', 'display_name': 'Masataka Moriyasu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I197065826', 'display_name': 'Kobe Pharmaceutical University', 'ror': 'https://ror.org/00088z429', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I197065826']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'M. Moriyasu', 'raw_affiliation_strings': ['Department of Natural Medicinal Chemistry, Faculty of Pharmacy, Kobe PharmaceuticalUniversity, Motoyamakitamachi 4-19-1, Higashinadaku, Kobe 658-8558, Japan.,Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Natural Medicinal Chemistry, Faculty of Pharmacy, Kobe PharmaceuticalUniversity, Motoyamakitamachi 4-19-1, Higashinadaku, Kobe 658-8558, Japan.,Japan', 'institution_ids': ['https://openalex.org/I197065826']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5082325000'], 'corresponding_institution_ids': ['https://openalex.org/I197065826'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.413, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 128, 'citation_normalized_percentile': {'value': 0.793727, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '10', 'issue': '15', 'first_page': '1353', 'last_page': '1374'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12533', 'display_name': 'Aldose Reductase and Taurine', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12533', 'display_name': 'Aldose Reductase and Taurine', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11924', 'display_name': 'Polyamine Metabolism and Applications', 'score': 0.9389, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/polyol-pathway', 'display_name': 'Polyol pathway', 'score': 0.9041414}, {'id': 'https://openalex.org/keywords/aldehyde-reductase', 'display_name': 'Aldehyde Reductase', 'score': 0.8865703}, {'id': 'https://openalex.org/keywords/sorbinil', 'display_name': 'Sorbinil', 'score': 0.54972064}, {'id': 'https://openalex.org/keywords/thioether', 'display_name': 'Thioether', 'score': 0.4847762}], 'concepts': [{'id': 'https://openalex.org/C2776439734', 'wikidata': 'https://www.wikidata.org/wiki/Q414213', 'display_name': 'Aldose reductase', 'level': 3, 'score': 0.9841433}, {'id': 'https://openalex.org/C136502266', 'wikidata': 'https://www.wikidata.org/wiki/Q7226667', 'display_name': 'Polyol pathway', 'level': 4, 'score': 0.9041414}, {'id': 'https://openalex.org/C2910800646', 'wikidata': 'https://www.wikidata.org/wiki/Q414213', 'display_name': 'Aldehyde Reductase', 'level': 4, 'score': 0.8865703}, {'id': 'https://openalex.org/C2776779347', 'wikidata': 'https://www.wikidata.org/wiki/Q245280', 'display_name': 'Sorbitol', 'level': 2, 'score': 0.8448584}, {'id': 'https://openalex.org/C2781171952', 'wikidata': 'https://www.wikidata.org/wiki/Q415812', 'display_name': 'Polyol', 'level': 3, 'score': 0.5759181}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5622833}, {'id': 'https://openalex.org/C2777374081', 'wikidata': 'https://www.wikidata.org/wiki/Q4713968', 'display_name': 'Aldose reductase inhibitor', 'level': 4, 'score': 0.5523987}, {'id': 'https://openalex.org/C2776614240', 'wikidata': 'https://www.wikidata.org/wiki/Q1259458', 'display_name': 'Sorbinil', 'level': 5, 'score': 0.54972064}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.52798706}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5017011}, {'id': 'https://openalex.org/C2779444094', 'wikidata': 'https://www.wikidata.org/wiki/Q727732', 'display_name': 'Thioether', 'level': 2, 'score': 0.4847762}, {'id': 'https://openalex.org/C134651460', 'wikidata': 'https://www.wikidata.org/wiki/Q3100717', 'display_name': 'Reductase', 'level': 3, 'score': 0.4710954}, {'id': 'https://openalex.org/C2780225610', 'wikidata': 'https://www.wikidata.org/wiki/Q127724', 'display_name': 'Cataracts', 'level': 2, 'score': 0.4571483}, {'id': 'https://openalex.org/C2781184683', 'wikidata': 'https://www.wikidata.org/wiki/Q1054718', 'display_name': 'Nephropathy', 'level': 3, 'score': 0.4538277}, {'id': 'https://openalex.org/C2776980637', 'wikidata': 'https://www.wikidata.org/wiki/Q427492', 'display_name': 'Enzyme inhibitor', 'level': 3, 'score': 0.43869102}, {'id': 'https://openalex.org/C2779829184', 'wikidata': 'https://www.wikidata.org/wiki/Q631361', 'display_name': 'Diabetic retinopathy', 'level': 3, 'score': 0.41941178}, {'id': 'https://openalex.org/C2778313320', 'wikidata': 'https://www.wikidata.org/wiki/Q550455', 'display_name': 'Retinopathy', 'level': 3, 'score': 0.41195986}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.4031019}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.3459073}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.34284696}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.2149134}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.1128715}, {'id': 'https://openalex.org/C118487528', 'wikidata': 'https://www.wikidata.org/wiki/Q161437', 'display_name': 'Ophthalmology', 'level': 1, 'score': 0.08844012}, {'id': 'https://openalex.org/C2779578285', 'wikidata': 'https://www.wikidata.org/wiki/Q146322', 'display_name': 'Polyurethane', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000449', 'descriptor_name': 'Aldehyde Reductase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000146', 'descriptor_name': 'Acids, Carbocyclic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000146', 'descriptor_name': 'Acids, Carbocyclic', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000146', 'descriptor_name': 'Acids, Carbocyclic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000449', 'descriptor_name': 'Aldehyde Reductase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000449', 'descriptor_name': 'Aldehyde Reductase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002599', 'descriptor_name': 'Chalcone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002599', 'descriptor_name': 'Chalcone', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002599', 'descriptor_name': 'Chalcone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003374', 'descriptor_name': 'Coumarins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003374', 'descriptor_name': 'Coumarins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003374', 'descriptor_name': 'Coumarins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004610', 'descriptor_name': 'Ellagic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004610', 'descriptor_name': 'Ellagic Acid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004610', 'descriptor_name': 'Ellagic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006072', 'descriptor_name': 'Gossypol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006072', 'descriptor_name': 'Gossypol', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006072', 'descriptor_name': 'Gossypol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039821', 'descriptor_name': 'Monoterpenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D039821', 'descriptor_name': 'Monoterpenes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D039821', 'descriptor_name': 'Monoterpenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013267', 'descriptor_name': 'Stilbenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013267', 'descriptor_name': 'Stilbenes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013267', 'descriptor_name': 'Stilbenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/0929867033457304', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S33159018', 'display_name': 'Current Medicinal Chemistry', 'issn_l': '0929-8673', 'issn': ['0929-8673', '1875-533X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12871134', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.65, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2903584670', 'https://openalex.org/W2415052159', 'https://openalex.org/W2281105313', 'https://openalex.org/W2189028775', 'https://openalex.org/W2162908938', 'https://openalex.org/W2157757005', 'https://openalex.org/W2143651350', 'https://openalex.org/W2084926467', 'https://openalex.org/W2041455832', 'https://openalex.org/W1997279264'], 'abstract_inverted_index': {'Aldose': [0], 'reductase': [1, 157], '(AR)': [2], 'is': [3, 34, 49, 87], 'an': [4], 'NADPH-dependent': [5], 'enzyme': [6], 'that': [7, 145], 'catalyses': [8], 'the': [9, 12, 15, 52, 60, 64, 90, 105, 120, 130, 147], 'reduction': [10], 'of': [11, 31, 45, 55, 70, 78, 85, 109, 122, 129], 'aldehyde': [13], 'to': [14, 50], 'corresponding': [16], 'alcohols.': [17], 'Diabetic': [18], 'complications': [19], 'including': [20], 'neuropathy,': [21], 'nephropathy,': [22], 'cataracts': [23], 'and': [24, 57, 76, 111, 138], 'retinopathy': [25], 'are': [26, 80, 99], 'considerately': [27], 'caused': [28], 'by': [29, 38], 'accumulation': [30], 'sorbitol,': [32], 'which': [33, 98], 'produced': [35], 'from': [36, 152], 'glucose': [37], 'AR': [39, 46, 93, 110, 148], 'in': [40, 63, 101, 119], 'polyol': [41, 61], 'pathway.': [42], 'The': [43, 125, 143], 'aim': [44], 'inhibitor': [47], 'therapy': [48], 'normalize': [51], 'elevated': [53], 'flux': [54], 'blood': [56], 'sorbitol': [58], 'through': [59], 'pathway': [62], 'target': [65], 'tissue.': [66], 'A': [67], 'large': [68], 'number': [69], 'inhibitors': [71, 94, 131, 149], 'have': [72, 95], 'been': [73, 96], 'prepared': [74], 'synthetically,': [75], 'some': [77, 114], 'them': [79, 86], 'used': [81], 'therapeutically.': [82], 'However,': [83], 'none': [84], 'satisfactory.': [88], 'From': [89], 'plants,': [91], 'many': [92], 'found,': [97], 'discussed': [100], 'this': [102], 'review.': [103], 'By': [104], 'structure': [106], 'based': [107], 'functioning': [108], 'its': [112], 'inhibitors,': [113, 159], 'will': [115, 132], 'be': [116, 133], 'developed': [117], 'promising': [118], 'treatment': [121], 'diabetic': [123, 153], 'complications.': [124, 154], 'main': [126], 'structural': [127], 'features': [128], 'a': [134, 139], 'polar': [135], 'head': [136], 'group': [137], 'hydrophobic': [140], 'ring': [141], 'system.': [142], 'plants': [144], 'contain': [146], 'may': [150], 'prevent': [151], 'Keywords:': [155], 'aldose': [156], '(ar)': [158], 'flavones,': [160], 'flavonols,': [161], 'flavanones,': [162], 'flavanonols,': [163], 'isoflavones,': [164], 'coumarins,': [165], 'ellagic': [166], 'acids,': [167], 'chalcones,': [168], 'acids': [169]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2156829110', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-12-10T04:01:13.092010', 'created_date': '2016-06-24'}