Publication Information

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2443, 2448, 2472, 2509, 2546, 2577, 2607, 2629, 2687, 2713, 2725, 2735, 2738, 2753, 2758, 2785, 2818, 2847, 2868, 2904, 2927, 2936, 2997, 3003, 3045, 3050, 3067, 3092, 3124, 3210, 3424, 3491, 3539, 3558, 3565, 3581, 3594, 3648, 3671, 3795, 3835, 3889, 3896, 3972, 4001, 4047, 4094, 4114, 4126, 4191, 4202, 4220, 4225, 4232, 4293, 4301], 'histone': [13, 57, 145, 161, 230, 274, 362, 378, 457, 679, 795, 803, 855, 875, 884, 938, 989, 1038, 1060, 1076, 1098, 1163, 1171, 1498, 1541, 1614, 1840, 1883, 2547, 2766, 2882, 3188, 3391, 3413, 3559, 3582, 3731, 3947], 'post-translational': [14, 231, 458, 991, 1036, 1074, 1446, 2548], 'modifications': [15, 232, 459, 522, 597, 796, 1164, 1447, 1778, 2549, 2976, 3512], '(marks).': [16, 233], 'A': [17, 234, 541, 871, 1500, 1797, 2814, 2993, 3195, 3386], 'key': [18, 235, 872], 'development': [19, 236, 873], 'in': [20, 147, 197, 237, 364, 414, 441, 452, 485, 512, 874, 907, 984, 1071, 1109, 1124, 1323, 1407, 1445, 1448, 1476, 1600, 1709, 1746, 1815, 1864, 1874, 1899, 1972, 2002, 2052, 2128, 2165, 2217, 2320, 2323, 2406, 2414, 2526, 2552, 2568, 2654, 2750, 2822, 2912, 2920, 2945, 2986, 3000, 3013, 3058, 3114, 3136, 3203, 3217, 3272, 3312, 3349, 3360, 3373, 3396, 3602, 3621, 3676, 3734, 4058, 4168], 'this': [21, 183, 238, 400, 1113, 1900, 3757], 'approach': [22, 239, 825, 1502], 'was': [23, 124, 139, 191, 240, 341, 356, 408, 878, 1932, 2207, 2274, 2282, 2585, 2597, 2616, 2746, 2761, 2780, 2796, 2824, 2849, 3009, 3134, 3222, 3400, 3597, 3975, 4031, 4041, 4109, 4223], 'deliberate': [25, 242, 880], 'propionylation': [26, 243, 1059, 1097, 1858, 2528, 2647, 2688, 3068, 4048], 'histones': [28, 245, 560, 841, 1020, 1449, 2358, 2381, 2400, 2411, 2434, 2451, 2473, 2716, 3216, 4066], 'improve': [30, 247], 'sequence': [31, 248], 'coverage': [32, 249], 'across': [33, 250, 3607], 'lysine-rich': [35, 252], 'and': [36, 52, 67, 73, 110, 129, 132, 143, 157, 171, 177, 188, 208, 215, 253, 269, 284, 290, 327, 346, 349, 360, 374, 388, 394, 405, 425, 432, 454, 521, 564, 566, 581, 583, 643, 677, 690, 834, 895, 982, 1120, 1277, 1320, 1451, 1605, 1633, 1666, 1700, 1707, 1754, 1759, 1777, 1826, 1846, 1885, 1907, 1946, 1983, 1991, 2039, 2103, 2132, 2213, 2237, 2266, 2271, 2287, 2364, 2388, 2404, 2426, 2437, 2550, 2580, 2593, 2603, 2621, 2645, 2663, 2683, 2728, 2755, 2770, 2827, 2838, 2860, 2898, 2921, 2940, 2949, 3018, 3038, 3082, 3150, 3168, 3283, 3319, 3344, 3445, 3448, 3451, 3454, 3493, 3510, 3513, 3532, 3548, 3572, 3611, 3674, 3689, 3727, 3761, 3764, 3767, 3770, 3773, 3827, 3883, 3965, 4025, 4080, 4145, 4174, 4204, 4242, 4255, 4278, 4322], 'hydrophilic': [37, 254, 903, 1890], 'tails': [38, 255], 'that': [39, 256, 1762, 2522, 3219, 3404, 3433, 4070, 4111], 'bear': [40, 257], 'most': [41, 258, 822, 4124], 'modifications.': [42, 259, 3541], 'Several': [43, 260], 'marks': [44, 146, 159, 261, 363, 376, 801, 1116, 1169, 1195, 1233, 1893, 3583, 3754, 3852, 3865], 'continue': [45, 262], 'be': [47, 63, 264, 280, 905, 3436, 3526, 3838, 3892, 4306], 'problematic': [48, 265], 'however,': [49, 266, 4315], 'particularly': [50, 267, 4185], 'di-': [51, 176, 268, 393, 1119], 'tri-methylated': [53, 270], 'lysine': [54, 206, 271, 423, 576, 578], '4': [55, 272, 2203, 2264, 2332, 2799], 'H3': [58, 275, 600, 990, 1039, 1077, 1450, 3392, 3810, 3874, 3948, 4237, 4295], 'which': [59, 276, 1477, 2891], 'we': [60, 277], 'found': [61, 278], 'subject': [64, 281, 3423, 3755], 'substantial': [66, 283], 'selective': [68, 285, 4175], 'losses': [69, 286], 'during': [70, 287, 2631], 'sample': [71, 288, 1844, 1852, 2702, 2706, 2833, 2875, 3096], 'preparation': [72, 289, 1845], 'liquid': [74, 291, 467, 494, 909, 1044, 1082, 3482], 'chromatography-mass': [75, 292, 910], 'spectrometry.': [76, 293], 'We': [77, 294, 1832], 'developed': [78, 140, 295, 357], 'new': [80, 113, 297, 330, 1501, 1866, 3073, 4052], 'method': [81, 298, 3016], 'employing': [82, 299], '"one-pot"': [84, 301], 'hybrid': [85, 302, 1867, 3015, 3229], 'chemical': [86, 303, 881, 1868], 'derivatization': [87, 304, 1018, 2471], 'histones,': [89, 306, 1479], 'whereby': [90, 307], 'an': [91, 166, 308, 383, 670, 836, 3125, 4086], 'initial': [92, 309, 837], 'conversion': [93, 310], 'free': [95, 312, 2692], 'lysines': [96, 313, 886, 932, 4261], 'their': [98, 315, 567, 3072, 3957, 4101, 4155], 'propionylated': [99, 316, 3010, 4241], 'forms': [100, 317, 4117, 4147, 4180], 'under': [101, 318, 2006, 3180], 'mild': [102, 319], 'aqueous': [103, 320], 'conditions': [104, 321, 2008], 'followed': [106, 323, 2195, 2334, 3305, 4042], 'by': [107, 165, 193, 201, 324, 382, 410, 418, 482, 509, 887, 1024, 1068, 1106, 1138, 1508, 2117, 2196, 2335, 2390, 2477, 2642, 2673, 2680, 2733, 2851, 2864, 3224, 3290, 3306, 3787, 3792, 4043, 4082, 4100, 4263], 'trypsin': [108, 325, 2670, 2806, 3023], 'digestion': [109, 326, 891, 2795, 3051, 4040, 4292], 'labeling': [111, 328, 481, 508, 1067, 1105, 3057, 3515], 'peptide': [114, 331, 2693, 2908, 2999, 3095, 3463, 3508, 3596, 3791, 3872, 4022, 4053, 4128, 4297, 4318], 'N': [115, 332, 2694, 3074, 4023, 4054], 'termini': [116, 333, 2695], 'with': [117, 334, 589, 857, 1189, 1608, 1662, 1766, 1892, 2026, 2065, 2185, 2242, 2276, 2326, 2337, 2600, 2669, 2719, 2748, 2768, 2782, 2803, 2894, 2901, 2924, 2933, 2956, 2980, 2988, 3020, 3064, 3141, 3192, 3521, 3528, 3588, 3925, 4013, 4064, 4131, 4244, 4246], 'phenyl': [118, 335, 1908, 1917, 2819], 'isocyanate.': [119, 336], 'High': [120, 337, 1536], 'resolution': [121, 338, 3338, 3359, 3372], 'mass': [122, 339, 469, 496, 832, 859, 978, 1025, 1046, 1084, 1213, 1474, 1511, 2478, 2506, 3130, 3152, 3233, 3331, 3364, 3387, 3406, 3427, 3430, 3484, 3518, 3645, 3998, 4088, 4170], 'used': [125, 342, 463, 490, 1898, 2941, 3054, 3909, 4213], 'collect': [127, 344], 'qualitative': [128, 345], 'quantitative': [130, 195, 347, 412, 858, 1191, 1212, 2505, 3644, 3997, 4183], 'data,': [131, 348], 'novel': [134, 351], 'web-based': [135, 352], 'software': [136, 353], 'application': [137, 354, 3473], '(Fishtones)': [138, 355], 'viewing': [142, 359], 'quantifying': [144, 361, 678], 'resulting': [149, 366, 1863, 2676, 3048, 4283], 'data': [150, 367, 3353, 3570, 3781], 'sets.': [151, 368], 'Recoveries': [152, 369], '53': [154, 371], 'methyl,': [155, 372], 'acetyl,': [156, 373], 'phosphoryl': [158, 375], 'on': [160, 377, 802, 1170, 1577, 2190, 2294, 2351, 2385, 2690, 2977, 2982, 3071, 3475, 3584, 3855, 4085], 'H3.1': [162, 379], 'were': [163, 380, 1860, 1950, 1961, 1970, 1992, 2000, 2016, 2050, 2063, 2101, 2115, 2141, 2156, 2163, 2253, 2292, 2318, 2359, 2382, 2412, 2435, 2452, 2566, 2640, 2652, 2678, 2717, 2862, 2884, 2892, 2910, 2931, 2965, 3052, 3079, 3097, 3161, 3190, 3242, 3334, 3347, 3408, 3421, 3455, 3465, 3782, 3952, 4062, 4106, 4118, 4129, 4148, 4212, 4240], 'improved': [164, 381, 1887], 'average': [167, 384], 'threefold': [169, 386], 'overall,': [170, 387], 'over': [172, 389, 590, 3302], '50-fold': [173, 390], 'H3K4': [175, 198, 392, 415, 1118], 'tri-methyl': [178, 395], 'marks.': [179, 396], 'The': [180, 397, 434, 558, 821, 1646, 2095, 2112, 2205, 2409, 2675, 2778, 3047, 3542, 3752, 4206, 4236], 'power': [181, 398], 'workflow': [184, 401, 1870], 'epigenetic': [186, 212, 403, 429], 'research': [187, 404], 'drug': [189, 406, 442, 524, 1780], 'discovery': [190, 407, 443, 1828], 'demonstrated': [192, 409], 'measuring': [194, 411], 'changes': [196, 413, 455], 'trimethylation': [199, 416], 'induced': [200, 417], 'small': [202, 419], 'molecule': [203, 420], 'inhibitors': [204, 421, 1960, 2187], 'demethylases': [207, 424], 'siRNA': [209, 426, 2046], 'knockdown': [210, 427], 'modifiers': [213, 430], 'ASH2L': [214, 431], 'WDR5.': [216, 433], 'field': [435], 'Epigenetics': [437], 'has': [438], 'become': [439], 'important': [440], 'as': [444, 523, 647, 681, 830, 1281, 1779, 2009, 2057, 2088, 2146, 2158, 2209, 2454, 2623, 2696, 2967, 3011, 3411, 3415, 3457, 4198], 'many': [445, 3412], 'diseases': [446, 1770], 'have': [447, 4165], 'been': [448, 4072], 'linked': [449], 'aberrations': [451], 'chromatin': [453, 789, 1157, 1402, 1631, 1702, 2272], '(PTMs)': [460], '1The': [461, 488], 'abbreviations': [462, 489], 'are:PTMpost-translational': [464, 491], 'modificationH3histone': [465, 492], 'H3me1mono-methylationme2di-methylationme3tri-methylationLC-MS/MSTandem': [466, 493], 'chromatography': [468, 495, 1045, 1083], 'spectrometryPICPhenyl': [470, 497], 'isocyanateHCDhigher': [471, 498], 'energy': [472, 499, 1051, 1089, 3381], 'collisional': [473, 500, 1052, 1090, 3382], 'dissociationC18Carbon': [474, 501], '18': [475, 502, 1055, 1093], 'columnacacetylationphosphosphorylationprpropionylationHMThistone': [476, 503], 'methyl': [477, 504, 1061, 1099, 2532], 'transferaseFMOC-ClFluorenylmethyloxycarbonyl': [478, 505], 'chlorideSILACStable': [479, 506], 'isotope': [480, 507, 1066, 1104, 4078, 4103], 'amino': [483, 510, 1069, 1107], 'acids': [484, 511, 1070, 1108], 'cell': [486, 513, 1072, 1110, 2161, 3377], 'culture.': [487, 514, 1073, 1111], '(1Helin': [515, 1771], 'K.': [516, 700, 1376, 1569, 1772, 3665, 3713], 'Dhanak': [517, 1773], 'D.': [518, 535, 722, 1731, 1774, 1791, 3663, 3707], 'Chromatin': [519, 1775], 'proteins': [520, 1507, 1776], 'targets.Nature.': [525, 1781], '2013;': [526, 1413, 1638, 1782], '502:': [527, 1783], '480-488Crossref': [528, 1784], 'PubMed': [529, 553, 662, 771, 816, 866, 944, 998, 1031, 1184, 1223, 1296, 1331, 1416, 1463, 1519, 1553, 1586, 1641, 1717, 1785, 1809, 2484, 2516, 2559, 3655, 3701, 3747, 4008], 'Scopus': [530, 554, 663, 772, 817, 867, 945, 999, 1032, 1185, 1224, 1297, 1332, 1417, 1464, 1520, 1554, 1587, 1642, 1718, 1786, 1810, 2485, 2517, 2560, 3656, 3702, 3748, 4009], '(346)': [531, 1787], 'Google': [532, 556, 665, 774, 819, 869, 947, 1001, 1034, 1187, 1226, 1299, 1334, 1419, 1466, 1522, 1556, 1589, 1644, 1720, 1788, 1812, 2487, 2519, 2562, 3658, 3704, 3750, 4011], 'Scholar,': [533, 775, 948, 1002, 1300, 1335, 1420, 1523, 1557, 1721, 1789, 2488, 3659, 3705], '2Rotili': [534, 1790], 'Mai': [536, 1792], 'A.': [537, 696, 730, 738, 1308, 1619, 1793], 'Targeting': [538, 1574, 1794], 'Histone': [539, 641, 644, 652, 1275, 1278, 1286, 1314, 1575, 1744, 1795, 2960], 'Demethylases:': [540, 1796], 'New': [542, 649, 1283, 1798], 'Avenue': [543, 1799], 'Fight': [546, 1802], 'against': [547, 794, 1162, 1803, 4177], 'Cancer.Genes': [548, 1804], 'Cancer.': [549, 1805], '2011;': [550, 654, 768, 863, 1288, 1806], '2:': [551, 1029, 1807, 2482], '663-679Crossref': [552, 1808], '(163)': [555, 1811], 'Scholar).': [557, 666, 820, 870, 1035, 1467, 1645, 1813, 2563, 3751], 'core': [559, 2399, 2433, 2450, 2715], '(H2A,': [561], 'H2B,': [562, 2402], 'H3,': [563, 1884, 2403, 2961], 'H4': [565, 2405, 3732], 'variants)': [568], 'undergo': [569], 'multitude': [571], 'PTMs.': [573], 'Some,': [574], 'like': [575, 1117, 1894], 'acetylation,': [577], 'mono-,': [579], 'di-,': [580], 'trimethlyation,': [582], 'serine/threonine': [584], 'phosphorylation': [585, 1058, 1096, 2981], 'are': [586, 684, 1484, 1764, 3545, 3853, 3905, 3908, 4161], 'well': [587], 'documented,': [588], '100': [591, 2569, 3004, 3249], 'distinct,': [592], 'albeit': [593], 'generally': [594], 'low': [595, 1651, 4192], 'abundance,': [596, 1653], 'reported': [598, 1230], 'alone': [601, 2984], '(3Tan': [602, 1236], 'M.': [603, 728, 848, 1237, 1353, 1428, 1617, 1621], 'Luo': [604, 1238], 'H.': [605, 1239, 1304, 1306, 1559, 1561], 'Lee': [606, 699, 1240], 'S.': [607, 619, 633, 698, 710, 718, 750, 956, 966, 1006, 1241, 1253, 1267, 1684, 2459], 'Jin': [608, 1242], 'F.': [609, 1243, 1357, 1400], 'Yang': [610, 1244], 'J.S.': [611, 1245], 'Montellier': [612, 1246], 'E.': [613, 1247, 1362, 1563], 'Buchou': [614, 1248], 'T.': [615, 714, 968, 1249, 1623], 'Cheng': [616, 1250], 'Z.': [617, 623, 625, 918, 1251, 1257, 1259, 1359, 1370, 1692], 'Rousseaux': [618, 1252], 'Rajagopal': [620, 1254], 'N.': [621, 1255, 1382, 1436], 'Lu': [622, 1256], 'Ye': [624, 630, 1258, 1264], 'Zhu': [626, 1260], 'Q.': [627, 726, 1261], 'Wysocka': [628, 1262], 'J.': [629, 740, 970, 1014, 1263, 1343, 1366, 1368, 1384, 1388, 1432, 1434, 1635, 2467, 3709], 'Y.': [631, 637, 724, 1265, 1271, 1339, 1675], 'Khochbin': [632, 1266], 'Ren': [634, 747, 1268, 1697], 'B.': [635, 748, 962, 964, 1269, 1698], 'Zhao': [636, 1270], 'Identification': [638, 1272], '67': [640, 1274], 'Marks': [642, 1276], 'Lysine': [645, 1279, 1958], 'Crotonylation': [646, 1280], 'Type': [650, 1284], 'Modification.Cell.': [653, 1287], '146:': [655, 1289], '1016-1028Abstract': [656, 1290], 'Full': [657, 659, 811, 813, 1179, 1181, 1291, 1293, 1458, 1460, 1548, 1550, 3330, 3696, 3698], 'Text': [658, 660, 812, 814, 1180, 1182, 1292, 1294, 1459, 1461, 1549, 1551, 3697, 3699], 'PDF': [661, 815, 1183, 1295, 1462, 1552, 3700], '(1151)': [664, 1298], 'provides': [669], 'detecting': [676], 'PTMs,': [680], 'latter': [683], 'prone': [685], 'problems': [687], 'specificity': [689], 'epitope': [691], 'occlusion': [692], '(4Egelhofer': [693], 'T.A.': [694], 'Minoda': [695], 'Klugman': [697], 'Kolasinska-Zwierz': [701], 'P.': [702, 1302, 1310], 'Alekseyenko': [703], 'A.A.': [704, 712], 'Cheung': [705], 'M.S.': [706], 'Day': [707], 'D.S.': [708], 'Gadel': [709], 'Gorchakov': [711], 'Gu': [713], 'Kharchenko': [715], 'P.V.': [716], 'Kuan': [717], 'Latorre': [719], 'I.': [720], 'Linder-Basso': [721], 'Luu': [723], 'Ngo': [725], 'Perry': [727], 'Rechtsteiner': [729], 'Riddle': [731], 'N.C.': [732], 'Schwartz': [733, 959], 'Y.B.': [734, 1490], 'Shanower': [735], 'G.A.': [736], 'Vielle': [737], 'Ahringer': [739], 'Elgin': [741], 'S.C.': [742], 'Kuroda': [743], 'M.I.': [744], 'Pirrotta': [745], 'V.': [746, 1374], 'Strome': [749], 'Park': [751], 'P.J.': [752], 'Karpen': [753], 'G.H.': [754], 'Hawkins': [755, 1678], 'R.D.': [756, 1679, 1694], 'Lieb': [757], 'J.D.': [758, 785, 1153, 1337], 'An': [759], 'assessment': [760, 787, 1155], 'histone-modification': [762], 'antibody': [763], 'quality.Nat.': [764], 'Struct.': [765], 'Mol.': [766, 1636], 'Biol.': [767, 1453], '18:': [769], '91-93Crossref': [770], '(312)': [773], '5Peach': [776], 'S.E.': [777, 1145], 'Rudomin': [778, 1146], 'E.L.': [779, 1147], 'Udeshi': [780, 1148], 'N.D.': [781, 1149, 1669], 'Carr': [782, 1150, 1393], 'S.A.': [783, 1010, 1151, 1394, 1430, 2463], 'Jaffe': [784, 1152], 'Quantitative': [786, 1154, 3668], 'immunoprecipitation': [790, 1158], 'grade': [791, 1159, 3205], 'antibodies': [792, 1160, 2329, 2341], 'directed': [793, 1161, 3116], 'reveals': [797, 1165, 1404], 'patterns': [798, 1166], 'co-occurring': [800, 1168], 'protein': [804, 1172, 2290, 2421], 'molecules.Mol.': [805, 1173], 'Cell.': [806, 1174, 1543, 3691], 'Proteomics.': [807, 862, 1175, 1544, 3692], '2012;': [808, 1176], '11:': [809, 1177], '128-137Abstract': [810, 1178], '(61)': [818, 1186], 'commonly': [823], 'applied': [824], 'date': [827], 'known': [829], '"bottom-up"': [831], 'involves': [835], 'processing': [838], 'into': [842, 898, 3099], 'smaller': [843], 'peptides': [844, 899, 1877, 1891, 1949, 2677, 2955, 3078, 3189, 3393, 3414, 3420, 3587, 3944, 3974, 4097, 4160, 4209, 4222, 4239, 4277, 4282], '(6Britton': [845], 'L.M.': [846], 'Gonzales-Cope': [847], 'Zee': [849, 1198, 2491, 3630, 3983], 'B.M.': [850, 1008, 1199, 2461, 2492, 2537, 3631, 3984], 'Garcia': [851, 963, 1208, 1534, 2501, 2542, 3640, 3993], 'B.A.': [852, 1004, 1209, 1422, 1535, 2457, 2502, 2543, 3641, 3994], 'Breaking': [853], 'code': [856], 'spectrometry.Expert': [860], 'Rev.': [861], '8:': [864, 1221, 1546, 2514, 3653, 4006], '631-643Crossref': [865], '(95)': [868], 'PTM': [876, 1841, 3560], 'modification': [882, 1037, 1075, 1869, 3958], 'tail': [885, 936, 1881], 'propionic': [888, 4017], 'anhydride,': [889], 'preventing': [890], 'these': [893, 1592, 3907, 3973, 4302], 'Lys-': [894], 'Arg-rich': [896], 'domains': [897], 'too': [900], 'short': [901], 'or': [902, 1228, 1472, 1480, 1851, 2073, 2801, 2943, 2969, 2974, 2979, 2985, 2990, 3031, 3062, 3069, 3369, 3850, 3921, 3932, 3934, 4135, 4230], 'detected': [906, 1135, 1232, 4130], 'reverse-phase': [908], 'experiments': [912, 3505], '(7Smith': [913], 'C.M.': [914], 'Gafken': [915], 'P.R.': [916], 'Zhang': [917, 1342, 1568], 'Gottschling': [919], 'D.E.': [920], 'Smith': [921, 923], 'J.B.': [922], 'D.L.': [924, 954], 'spectrometric': [926], 'quantification': [927], 'acetylation': [929, 1057, 1095], 'at': [930, 1234, 1963, 1994, 2077, 2105, 2119, 2198, 2202, 2249, 2256, 2263, 2331, 2346, 2439, 2605, 2636, 2665, 2775, 2791, 2843, 2951, 3028, 3032, 3146, 3156, 3267, 3285, 3321, 3336, 3341, 3357, 3370, 3438, 3576, 3687, 3960, 3969, 4249, 4269, 4308], 'specific': [931, 4178], 'within': [933], 'amino-terminal': [935], 'H4.Anal.': [939], 'Biochem.': [940], '2003;': [941], '316:': [942], '23-33Crossref': [943], '(144)': [946], '8Syka': [949], 'J.E.': [950, 1351], 'Marto': [951], 'J.A.': [952, 3721], 'Bai': [953], 'Horning': [955], 'Senko': [957], 'M.W.': [958], 'J.C.': [960], 'Ueberheide': [961, 1007, 2460], 'Busby': [965, 1009, 2462], 'Muratore': [967, 1011, 2464], 'Shabanowitz': [969, 1013, 1433, 2466], 'Hunt': [971, 1015, 1441, 2468], 'D.F.': [972, 1016, 1442, 2469], 'Novel': [973], 'linear': [974, 3230, 3292], 'quadrupole': [975], 'ion': [976, 3119, 3138, 3231, 3362, 3501, 3605], 'trap/FT': [977], 'spectrometer:': [979], 'performance': [980], 'characterization': [981, 1215, 1505, 1538, 2508, 3647, 4000], 'use': [983], 'comparative': [986], 'modifications.J.': [992], 'Proteome': [993, 1218, 2511, 3650, 4003], 'Res.': [994, 1219, 2512, 3651, 4004], '2004;': [995, 1516], '3:': [996, 2557], '621-626Crossref': [997], '(333)': [1000], '9Garcia': [1003], 'Mollah': [1005, 2458], 'T.L.': [1012, 2465], 'Chemical': [1017, 1896, 2470], 'facilitated': [1022, 2475], 'spectrometry.Nat.': [1026, 2479], 'Protocols.': [1027, 2480], '2007;': [1028, 1455, 1714, 2481], '933-938Crossref': [1030, 2483], '(279)': [1033, 2486], 'mono-methylation': [1040, 1078], 'di-methylation': [1041, 1079], 'tri-methylation': [1042, 1080, 1121], 'Tandem': [1043, 1081, 3517], 'Phenyl': [1048, 1086, 1930], 'isocyanate': [1049, 1087, 1909, 1919, 2820], 'higher': [1050, 1088, 3380], 'dissociation': [1053, 1091], 'Carbon': [1054, 1092], 'column': [1056, 1094, 3247], 'transferase': [1062, 1100], 'Fluorenylmethyloxycarbonyl': [1063, 1101], 'chloride': [1064, 1102], 'Stable': [1065, 1103], 'Despite': [1112], 'advance,': [1114], 'some': [1115, 4226], 'remain': [1122], 'problematic;': [1123], 'several': [1125], 'examples': [1126], 'from': [1127, 1596, 1878, 1903, 1934, 1952, 2188, 2361, 2959, 3294, 3599, 3778, 4067, 4284], 'recent': [1129], 'literature': [1130], 'H3K4me3': [1132, 1647], 'mark': [1133, 1648, 1763, 3904], 'either': [1136, 3053], 'only': [1137], 'means': [1139], 'specifically': [1141], 'targeted': [1142], '(5Peach': [1144], 'Scholar),': [1188, 1227, 1590, 1753], 'larger': [1190], 'variation': [1192], 'than': [1193, 4137], 'other': [1194], '(10Plazas-Mayorca': [1196, 3628, 3981], 'M.D.': [1197, 1529, 2490, 3629, 3982], 'Young': [1200, 2493, 3632, 3985], 'N.L.': [1201, 1494, 1525, 2494, 3633, 3986], 'Fingerman': [1202, 2495, 3634, 3987], 'I.M.': [1203, 2496, 3635, 3988], 'LeRoy': [1204, 2497, 3636, 3989], 'G.': [1205, 1386, 1673, 2498, 3637, 3990], 'Briggs': [1206, 2499, 3638, 3991], 'S.D.': [1207, 2500, 3639, 3992], 'One-pot': [1210, 2503, 3642, 3995], 'shotgun': [1211, 2504, 3643, 3996], 'histones.J.': [1217, 2510, 3649, 4002], '2009;': [1220, 1545, 2513, 3652, 4005], '5367-5374Crossref': [1222, 2515, 3654, 4007], '(111)': [1225, 2518, 3657, 4010], 'not': [1229, 4162], 'among': [1231, 3923, 3935], 'all': [1235, 3796, 4149, 4260, 4300], '11Drogaris': [1301], 'Wurtele': [1303], 'Masumoto': [1305], 'Verreault': [1307], 'Thibault': [1309], 'Comprehensive': [1311], 'Profiling': [1312, 1742], 'Modifications': [1315, 1576, 3686], 'Using': [1316], 'Label-Free': [1318], 'Approach': [1319], 'Its': [1321], 'Applications': [1322], 'Determining': [1324], 'Structure-Function': [1325], 'Relationships.Anal.': [1326], 'Chem.': [1327, 1454, 1514, 1582], '2008;': [1328, 3744], '80:': [1329], '6698-6707Crossref': [1330], '(34)': [1333], '12Jaffe': [1336], 'Wang': [1338, 1358, 1689], 'Chan': [1340], 'H.M.': [1341], 'Huether': [1344], 'R.': [1345, 1372, 1378], 'Kryukov': [1346], 'G.V.': [1347], 'Bhang': [1348], 'H.E.': [1349], 'Taylor': [1350, 1491], 'Hu': [1352], 'Englund': [1354], 'N.P.': [1355], 'Yan': [1356], 'Robert': [1360], 'McDonald': [1361], 'Wei': [1363], 'L.': [1364], 'Ma': [1365], 'Easton': [1367], 'Yu': [1369], 'deBeaumount': [1371], 'Gibaja': [1373], 'Venkatesan': [1375], 'Schlegel': [1377], 'Sellers': [1379], 'W.R.': [1380], 'Keen': [1381], 'Liu': [1383], 'Caponigro': [1385], 'Barretina': [1387], 'Cooke': [1389], 'V.G.': [1390], 'Mullighan': [1391], 'C.': [1392, 1686], 'Downing': [1395], 'J.R.': [1396], 'Garraway': [1397], 'L.A.': [1398], 'Stegmeier': [1399], 'Global': [1401, 2544], 'profiling': [1403], 'NSD2': [1405], 'mutations': [1406], 'pediatric': [1408], 'acute': [1409], 'lymphoblastic': [1410], 'leukemia.Nat.': [1411], 'Genet.': [1412, 1713], '45:': [1414], '1386-1391Crossref': [1415], '(185)': [1418], '13Garcia': [1421], 'Hake': [1423], 'S.B.': [1424], 'Diaz': [1425], 'R.L.': [1426], 'Kauer': [1427], 'Morris': [1429], 'Recht': [1431], 'Mishra': [1435], 'Strahl': [1437], 'B.D.': [1438], 'Allis': [1439], 'C.D.': [1440], 'Organismal': [1443], 'differences': [1444], 'H4.J.': [1452], '282:': [1456], '7641-7655Abstract': [1457], '(246)': [1465], 'Alternative': [1468], 'approaches': [1469], 'include': [1470], 'top-down': [1471], 'middle-down': [1473], 'spectrometry,': [1475], 'entire': [1478], 'large': [1481, 4173], 'segments': [1482], 'thereof': [1483], 'analyzed': [1485, 3080, 3223, 4081], 'directly': [1486], '(14Pesavento': [1487], 'J.J.': [1488, 3723], 'Kim': [1489], 'G.K.': [1492], 'Kelleher': [1493], 'Shotgun': [1495], 'annotation': [1496], 'modifications:': [1499], 'streamlined': [1504], 'top': [1509], 'down': [1510], 'spectrometry.J.': [1512], 'Am.': [1513], 'Soc.': [1515], '126:': [1517], '3386-3387Crossref': [1518], '(140)': [1521], '15Young': [1524], 'DiMaggio': [1526], 'P.A.': [1527, 2541], 'Plazas-Mayorca': [1528], 'Baliban': [1530], 'R.C.': [1531], 'Floudas': [1532], 'C.A.': [1533], 'throughput': [1537], 'combinatorial': [1540, 1611], 'codes.Mol.': [1542], '2266-2284Abstract': [1547], '(245)': [1555], '16Tang': [1558], 'Fang': [1560], 'Yin': [1562], 'Brasier': [1564], 'A.R.': [1565], 'Sowers': [1566], 'L.C.': [1567], 'Multiplexed': [1570], 'Parallel': [1571], 'Reaction': [1572], 'Monitoring': [1573], 'QExactive': [1579], 'Spectrometer.Anal.': [1581], '2014;': [1583], '86:': [1584], '5526-5534Crossref': [1585], '(52)': [1588], 'but': [1591], 'techniques': [1593], 'still': [1594], 'suffer': [1595], 'relatively': [1597], 'poor': [1598], 'sensitivity': [1599], 'comparison': [1601, 3918], 'bottom-up': [1603, 1839], 'workflows,': [1604], 'must': [1606], 'contend': [1607], 'full': [1610, 3426], 'complexity': [1612], 'PTMs': [1615], '(17Soldi': [1616], 'Cuomo': [1618], 'Bremang': [1620], 'Bonaldi': [1622], 'spectrometry-based': [1625], 'proteomics': [1626], 'structure': [1632], 'dynamics.Int.': [1634], 'Sci.': [1637, 3742], '14:': [1639], '5402-5431Crossref': [1640], '(25)': [1643], 'natural': [1652, 4193], 'having': [1654], 'very': [1656], 'restricted': [1657], 'genomic': [1658], 'localization': [1659], 'strongly': [1660], 'associated': [1661, 1765, 3520], 'active': [1663], 'gene': [1664], 'promotors': [1665], 'enhancers': [1667, 1708], '(18Heintzman': [1668], 'Stuart': [1670], 'R.K.': [1671], 'Hon': [1672], 'Fu': [1674], 'Ching': [1676, 1687], 'C.W.': [1677], 'Barrera': [1680], 'L.O.': [1681], 'Van': [1682], 'Calcar': [1683], 'Qu': [1685], 'K.A.': [1688], 'W.': [1690], 'Weng': [1691], 'Green': [1693], 'Crawford': [1695], 'G.E.': [1696], 'Distinct': [1699], 'predictive': [1701], 'signatures': [1703], 'transcriptional': [1705], 'promoters': [1706], 'human': [1711, 2553, 3736], 'genome.Nat.': [1712], '39:': [1715], '311-318Crossref': [1716], '(2409)': [1719], '19Barski,': [1722], 'A.,': [1723], 'Cuddapah,': [1724], 'S.,': [1725], 'Cui,': [1726], 'K.,': [1727, 1740], 'Roh,': [1728], 'T.-Y.,': [1729], 'Schones,': [1730], 'E.,': [1732], 'Wang,': [1733], 'Z.,': [1734], 'Wei,': [1735], 'G.,': [1736], 'Chepelev,': [1737], 'I.,': [1738], 'Zhao,': [1739], 'High-Resolution': [1741], 'Methylations': [1745], 'Human': [1748], 'Genome.': [1749], 'Cell': [1750], '129,': [1751], '823–837.Google': [1752], 'aberrant': [1755], 'activities': [1756], 'writers': [1758], 'erasers': [1760], 'variety': [1768, 3490], 'Difficulties': [1814], 'its': [1816], 'quantitation': [1817], 'thus': [1818], 'hinder': [1819], 'investigation': [1821], 'both': [1823, 3864], 'fundamental': [1824], 'biology': [1825], 'lifesaving': [1830], 'drugs.': [1831], 'therefore': [1833], 'undertook': [1834], 're-evaluation': [1836], 'workflow,': [1842], 'streamlining': [1843], 'investigating': [1847], 'sources': [1848], 'bias': [1850], 'loss.': [1853], 'Alternatives': [1854], 'standard': [1857, 3929, 3939], 'technique': [1859], 'also': [1861, 4032], 'explored,': [1862], 'yielding': [1871, 2394, 4273], 'across-the-board': [1872], 'improvements': [1873], 'recovery': [1875, 4219], 'N-terminal': [1880], 'dramatically': [1886], 'detection': [1888, 2350], 'H3K4me2/me3.': [1895], 'regents': [1897], 'study': [1901], 'purchased': [1902, 1933, 1951], 'Sigma-Aldrich:': [1904], 'Propionic': [1905, 2595, 2744], 'anhydride': [1906, 2596, 2745, 4018], '(Fluka': [1910], 'brand),': [1911, 1921], 'perchloric': [1912, 2391], 'acid,': [1913, 3110, 3199, 3279], 'hydroxylamine': [1914, 2788], '(50%': [1915], 'wt%),': [1916], '13C6': [1918], '(Aldrich': [1920], '1': [1922, 2020, 2106, 2223, 2344, 2444, 2708, 2736, 2739, 2756, 2783, 3026, 3090, 3286, 3816, 3820, 3829], 'm': [1923, 2224, 2740], 'Triethylammonium': [1924, 2741, 3006], 'bicarbonate': [1925, 2572, 2658, 2742, 3007], 'buffer': [1926, 2169, 3008], 'solution': [1927, 2817], '(Sigma': [1928], 'brand).': [1929], 'isothiocyanate': [1931], 'Acros': [1935], 'Organics': [1936], '(Geel,': [1937], 'Belgium).': [1938], 'Agilent': [1939], 'Technologies': [1940, 1955], '(Santa': [1941], 'Clara,': [1942], 'CA)': [1943], 'supplied': [1944], 'orthopthalaldehyde': [1945], 'FMOC-Cl.': [1947], 'Synthetic': [1948, 2954], 'JPT': [1953], 'Peptide': [1954], '(Berlin,': [1956], 'Germany).': [1957], 'demethylase': [1959], 'synthesized': [1962], 'WuXi': [1964], 'AppTec': [1965], '(Shanghai,': [1966], 'China).': [1967], 'HEK293T': [1968], 'cells': [1969, 1999, 2015, 2049, 2062, 2100, 2109, 2114, 2140, 2155, 2363, 4069], 'grown': [1971, 2001, 2051], "Dulbecco's": [1973, 2053], 'modified': [1974, 2054, 4116, 4179, 4188, 4221], "Eagle's": [1975, 2055], 'medium': [1976, 2005, 2056], 'containing': [1977, 2269, 3088], 'antibiotics': [1978], '(100': [1979, 2659], 'units/L': [1980], 'Pen/Strep,': [1981], 'Gibco)': [1982], 'l-Glutamine': [1984], '(1×': [1985], 'Glutamax,': [1986], 'Gibco;': [1987], 'Grand': [1988, 2031, 2301, 2857], 'Island,': [1989, 2032, 2302, 2858], 'NY)': [1990, 2303, 2859], 'harvested': [1993, 2157], 'around': [1995], '90%': [1996, 3317], 'confluency.': [1997], 'PC9': [1998], 'RPMI': [2003], '1640': [2004], 'similar': [2007, 3624], 'described': [2010, 2147, 2455, 2697, 3012], 'above.': [2011, 2058, 2148, 2159], '3': [2012, 2124, 2247, 2828, 2934], '×': [2013, 2060, 2107, 2121, 2200, 2258, 3817, 3821, 3825, 3830, 3840, 3842], '106': [2014, 2061, 2108], 'transfected': [2017, 2064, 2142], 'using': [2018, 2084, 2304, 2366, 2886, 3163, 3227, 3467], 'Dharmafect': [2019], 'according': [2021, 2375, 3977], "manufacturer's": [2024, 2091, 2378], 'protocol': [2025, 2092], 'following': [2028, 2151, 3753], 'siRNAs': [2029], '(Ambion,': [2030], 'NY):': [2033], 's17302': [2034, 2038], '(siAsh2L),': [2035], 's225470': [2036, 2040], '(siWdr5),': [2037], '(siAsh-Wdr).': [2041], 'Nontarget-control': [2042], '(NTC):': [2043], 'siGenome': [2044], 'nontargeting': [2045, 2075], '#4.': [2047], 'HeLa': [2048], '2.5': [2059], 'same': [2067, 3801, 4207], "siRNA's": [2068], 'targeting': [2069], 'ASH2,': [2070], 'WDR5,': [2071], 'β-actin,': [2072], 'control': [2076], 'final': [2079, 2420, 2836, 3208], 'concentration': [2080, 2281, 2422], '10': [2082, 2178, 2431, 2578, 3001, 3253, 3265], 'nm': [2083], 'Hiperfect': [2085], 'transfection': [2086], 'reagent': [2087, 2601], 'per': [2089, 2110, 2812, 3103, 3270, 3288], '(Qiagen;': [2093], 'Venlo,': [2094], 'Netherlands).': [2096], 'Seventy-two': [2097, 2149], 'hour': [2098], 'post-transfection,': [2099], 'trypsinized': [2102], 'reseeded': [2104], 'plate.': [2111], 'remaining': [2113], 'pelleted': [2116, 2130], 'centrifugation': [2118, 2197, 2644, 2682], '500': [2120, 3213], 'g': [2122, 2201, 2259], 'min,': [2125, 2194, 3314], 'washed': [2126, 2922], 'once': [2127], 'PBS,': [2129, 2324], 'again,': [2131], 'stored': [2133, 2438, 2950], 'processing.': [2135, 3552], 'Twenty-four': [2136], 'hours': [2137, 2150], 'after': [2138, 3083], 'replating,': [2139], 'second': [2144, 2153, 4045], 'time': [2145, 3043, 4257, 4289, 4310], 'transfection,': [2154], 'All': [2160], 'pellets': [2162], 'lysed': [2164], 'hypotonic': [2167], 'lysis': [2168], '(10': [2170], 'mm': [2171, 2176, 2179, 2182, 2219, 2229, 2232, 2235, 2570, 2787, 2835, 3005], 'Tris,': [2172], 'pH': [2173, 2221, 2590, 2628, 2661, 2731], '7.9,': [2174], '1.5': [2175, 2228, 3268], 'MgCl2,': [2177, 2230], 'KCl,': [2180], '0.5': [2181, 2234, 2425, 2581], 'dithiotreitol,': [2183, 2236], 'supplemented': [2184], 'protease': [2186, 2238], 'Roche)': [2189], 'ice': [2191], '15': [2193, 2633, 3313], '2500': [2199], '°C.': [2204, 2441, 2638, 2845, 2953], 'supernatant': [2206, 2268], 'saved': [2208], 'cytoplasmic': [2211, 2278], 'fraction,': [2212], 'pellet': [2215], 'resuspended': [2216, 2413, 2653, 3191], '20': [2218, 2261, 2902, 2925], 'HEPES': [2220], '7.5,': [2222], 'NaCl,': [2225], '20%': [2226, 3111], 'glycerol,': [2227], '0.1': [2231, 2804, 3021], 'EDTA,': [2233], 'inhibitors,': [2239], 'then': [2240, 2899, 3315, 3546, 3885], 'sonicated': [2241], 'Branson': [2244], 'sonicator': [2245], 's': [2248], 'setting': [2250], '3.': [2251], 'Lysates': [2252], 'spun': [2254], 'again': [2255], '16,000': [2257], 'min': [2262, 2634, 2774, 2790, 2842, 3040, 3266, 3304], '°C,': [2265, 2333, 3030], 'nuclear': [2270], 'fractions': [2273], 'pooled': [2275], 'fraction.': [2279], 'Protein': [2280], 'determined': [2283], 'via': [2284], 'Bradford': [2285], 'assay,': [2286], 'equal': [2288, 4133], 'total': [2289, 2575, 2723, 3178, 3215, 3327], 'loads': [2291], 'run': [2293, 3328], '4–12%': [2295], 'gradient': [2296, 3293], 'Bis-Tris': [2297], 'gel': [2298], '(Life': [2299], 'Technologies;': [2300], 'MES': [2305], 'running': [2306], 'buffer,': [2307], 'before': [2308, 2349, 2699, 3081], 'transferring': [2309], '0.2': [2311], 'micron': [2312], 'nitrocellulose': [2313], '(Bio-Rad;': [2314], 'Hercules,': [2315], 'CA).': [2316], 'Blots': [2317], 'blocked': [2319, 4262], '5%': [2321], 'milk': [2322], 'probed': [2325], 'indicated': [2327], 'primary': [2328], 'overnight': [2330, 2668, 2802], 'incubation': [2336, 2771], 'DyLight': [2338], 'coupled': [2339], 'secondary': [2340], '(Thermo)': [2342], 'h': [2345, 2800, 3027], 'room': [2347, 2776, 2792], 'temperature,': [2348], 'LiCor': [2353], 'Odyssey': [2354], 'imaging': [2355], 'system.': [2356], 'Core': [2357], 'extracted': [2360, 3162, 3523, 3549], 'cultured': [2362], 'column-purified': [2365], '"Histone': [2368], 'Purification': [2369], 'Mini': [2370], 'Kit"': [2371], '(Active': [2372], 'Motif,': [2373], '#40026)': [2374], 'instructions.': [2379], 'Briefly,': [2380, 2564], 'acid-extracted,': [2383], 'enriched': [2384], 'ion-exchange': [2386], 'spin-columns': [2387], 'desalted': [2389, 2885, 3187], 'acid': [2392, 2871], 'precipitation,': [2393], 'mixture': [2396], 'H2A,': [2401], 'high': [2407], 'purity.': [2408], 'purified': [2410, 2449, 2714], 'HPLC-grade': [2415], 'dH2O': [2416], '(ddH2O)': [2417], 'between': [2424, 2591], '1.0': [2427], 'μg/μl.': [2428], 'Aliquots': [2429, 2442], 'μg': [2432, 2447, 2711, 2805, 3022], 'flash-frozen': [2436], '−80': [2440], '5': [2446, 2710, 3035, 4313], 'prepared': [2453, 2826, 4073], '(9Garcia': [2456], '10Plazas-Mayorca': [2489], 'Scholar)': [2520, 4012], 'except': [2521, 3955, 4075], 'isopropanol': [2523, 2602], 'replaced': [2524], 'methanol': [2525], 'reaction': [2529, 2635, 2648, 2779], 'minimize': [2531], 'ester': [2533], 'side': [2534], 'products': [2535, 3049, 4304], '(20Zee': [2536], 'Levin': [2538], 'R.S.': [2539], 'Dimaggio': [2540], 'turnover': [2545], 'variants': [2551], 'cells.Epigenetics': [2554], 'Chromatin.': [2555], '2010;': [2556, 3693], '22Crossref': [2558], '(103)': [2561], 'samples': [2565, 2651, 2861, 2883, 2909, 3924, 3936], 'diluted': [2567, 2718, 2911], 'ammonium': [2571, 2583, 2657], 'volume': [2576, 2612, 2724], 'μl': [2579, 2582, 2619, 2656, 2727, 2737, 2757, 2784, 2829, 2867, 2903, 2914, 2926, 2935, 3002, 3102, 3269, 3287], 'hydroxide': [2584], 'added': [2586, 2604, 2617, 2762, 2830], 'bring': [2588], '8.0': [2592], '9.0.': [2594], 'mixed': [2598, 2747, 4063], '1:3': [2599], 'amounts': [2606], 'half': [2608], "sample's": [2610], 'starting': [2611, 4317], '(5': [2613], 'μl).': [2614], 'Ammonia': [2615], '(3': [2618], 'immediately,': [2620], 'subsequently': [2622], 'needed)': [2624], 'maintain': [2626], '∼8': [2630], '37': [2637, 2666, 2844, 3029], 'Samples': [2639], 'dried': [2641, 2679, 2944], 'vacuum': [2643, 2681, 2947], 'repeated.': [2649], 'Dried': [2650], '50': [2655], 'mm,': [2660], '8)': [2662], 'digested': [2664, 3019, 4234, 4243], '°C': [2667], '(1:20': [2671], 'enzyme-to-substrate': [2672], 'weight).': [2674], 'two': [2684, 3585, 3849, 4271, 4280], 'more': [2685, 3851], 'rounds': [2686], 'performed': [2689, 2797], 'above': [2698, 4211], 'desalting': [2700], '(below).': [2703], 'For': [2704, 3578, 3868], 'each': [2705, 2832, 2874, 2998, 3093, 3147, 3171, 3184, 3595, 3789, 3903], 'reaction,': [2707], 'aliquots': [2712, 3087, 4247], 'ddH2O': [2720, 2749], '9': [2726], 'buffered': [2729], '8.5': [2732], 'addition': [2734], 'buffer.': [2743], 'ratio': [2752, 3155], '1:100': [2754], 'anhydride-mixture': [2760], 'immediately': [2763, 2942], 'sample,': [2767], 'vortexing,': [2769], '2': [2773, 3824, 3839], 'temperature.': [2777], 'quenched': [2781], '80': [2786], '(20': [2789], 'temperature).': [2793], 'Tryptic': [2794], '(Promega': [2807], 'Sequencing': [2808], 'Grade;': [2809], 'Madison,': [2810], 'WI)': [2811], 'sample.': [2813], '1%': [2815, 2869], 'v/v': [2816, 3108, 3112, 3197, 3201, 3277, 3281], '(PIC)': [2821], 'acetonitrile': [2823, 3113, 3202], 'freshly': [2825], '(17': [2834], 'concentration)': [2837], 'incubated': [2839], '60': [2841, 2913, 3303], 'Efficiency': [2846], 'PIC-labeling': [2848], 'checked': [2850], 'MALDI-TOF': [2852], '(4800': [2853], 'Plus;': [2854], 'Applied': [2855, 3126], 'Biosystems,': [2856], 'acidified': [2863], 'adding': [2865], '8': [2866], 'trifluoroacetic': [2870], '(TFA)': [2872], 'prior': [2876], 'C18': [2878, 3246], 'stage-tip': [2879, 2919, 3084], 'purification.': [2880], 'Labeled': [2881], 'C18-stage-tips': [2887], '(Thermo': [2888], 'Scientific;': [2889], '#SP201),': [2890], 'wetted': [2893], '60%': [2895, 2937], 'Acetonitrile/0.1%': [2896, 2938], 'TFA': [2897, 2939], 'equilibrated': [2900], '0.1%': [2905, 2928], 'TFA.': [2906, 2929], 'Acidified': [2907], 'ddH2O,': [2915], 'loaded': [2916, 3243], 'onto': [2917, 3244], 'twice': [2923], 'Peptides': [2930, 3241], 'eluted': [2932], 'centrifuge': [2948], '−20': [2952], 'base': [2957, 3802], 'sequences': [2958, 3509], 'residues': [2962, 3811, 3875, 3949], '1–17': [2963, 3950], '(ARTKQTARKSTGGKAPR)': [2964, 3951], 'procured': [2966], 'unmodified,': [2968], 'bearing': [2970], 'monomethyl,': [2971, 4036], 'dimethyl,': [2972, 4142], 'trimethyl,': [2973, 4143], 'acetyl': [2975], 'K4,': [2978], 'T6,': [2983], 'combination': [2987], 'monomethyl': [2989], 'dimethyl': [2991], 'K4.': [2992, 4038], '200': [2994, 3101, 3211], 'pmol': [2995], 'aliquot': [2996], 'above,': [3017], '(Promega)': [3024], '1,': [3033, 4250], '2,': [3034, 4251], '10,': [3036, 4253], '20,': [3037, 4254], '30': [3039], 'course': [3044, 4290], 'digestion.': [3046, 4286], 'without': [3055, 3937, 4076], 'further': [3056, 3551], 'time-course': [3060], 'experiment,': [3061], 'derivatized': [3063, 3077], 'another': [3065], 'round': [3066, 4046], 'PIC': [3070], 'termini.': [3075, 4055], 'Fully': [3076], 'desalting.': [3085], 'Five-μl': [3086], 'nominally': [3089, 4059], 'pmol/μl': [3091], 'synthetic': [3094, 3943, 4096, 4208], 'injected': [3098], 'minute': [3104, 3271, 3289], 'solvent': [3105, 3194, 3274, 3296, 3300], 'stream': [3106], '(0.1%': [3107, 3196, 3276], 'formic': [3109, 3198, 3278], 'water)': [3115, 3206], 'source': [3120], '(Turbo': [3121], 'Ion': [3122], 'Spray)': [3123], 'Biosystems': [3127], '4000': [3128], 'QTRAP': [3129], 'spectrometer.': [3131, 4089], 'This': [3132], 'instrument': [3133], 'operated': [3135], 'selected': [3137], 'monitoring': [3139], 'mode,': [3140], '125': [3142], 'ms': [3143], 'dwell': [3144], 'times': [3145], "peptide's": [3148], '[M+H]+': [3149], '[M+2H]2+': [3151], 'charge': [3154, 3172], 'unit': [3157, 3358], 'resolution.': [3158], 'Peak': [3159], 'areas': [3160, 3169, 3777, 3798, 4093], "vendor's": [3165], 'MultiQuant': [3166], 'software,': [3167], 'state': [3173], 'summed': [3174], 'obtain': [3176], 'area': [3179, 3618, 3861], 'curve': [3182], 'peptide.': [3185], 'Stage-tip': [3186], 'HPLC': [3193, 3204], '2%': [3200, 3273, 3295, 3322], 'concentrations': [3209], 'ng/μl': [3214], 'order': [3218], '∼500': [3220], 'ng': [3221], 'capillary': [3225, 4083], 'LC-MS/MS': [3226, 4084], 'trap/Orbitrap': [3232], 'spectrometer': [3234], '(Orbitrap-Elite;': [3235], 'Thermo': [3236], 'Fisher': [3237], 'Scientific,': [3238], 'Waltham,': [3239], 'MA).': [3240], '(BEH-C18;': [3248], 'μm': [3250, 3256], 'i.d.': [3251], 'x': [3252], 'cm;': [3254], '1.7': [3255], 'particles,': [3257], '130Å': [3258], 'pores;': [3259], 'Waters': [3260], 'Corp.,': [3261], 'Milford,': [3262], 'MA)': [3263], 'B': [3275, 3297, 3301, 3311, 3318, 3323], '98%': [3280], 'acetonitrile)': [3282], 'separated': [3284], '25%': [3299], 'ramp': [3308], '40%': [3310], 're-equilibration': [3320], '90-min': [3326], 'time.': [3329], 'range': [3332, 3428, 3614], 'spectra': [3333, 3407, 3431, 3519, 3606], 'collected': [3335, 3348], '60,000': [3337], '(M/Δ': [3339], 'M': [3340], 'm/z': [3342], '400),': [3343], 'product': [3345, 3530, 3604], 'ions': [3346, 3601], '"top': [3351], '15"': [3352], 'dependent': [3354], 'scan': [3355], 'cycle': [3356], 'trap': [3363], 'analyzer': [3365], '(resonance': [3366], 'collision-induced': [3367], 'dissociation)': [3368], '15,000': [3371], 'Orbitrap': [3375, 4087], '(collision': [3376], 'CID;': [3378], 'i.e.': [3379], 'dissociation,': [3383], '(HCD)),': [3384], 'respectively.': [3385], 'inclusion': [3388], 'list': [3389], '(as': [3394], 'shown': [3395], 'supplemental': [3397], 'Table': [3398], 'S1)': [3399], 'specified': [3401], 'ensure': [3403], 'tandem': [3405, 3429], 'acquired': [3409], 'possible.': [3416], 'Certain': [3417], 'co-eluting,': [3418], 'isobaric': [3419], 'scheduled,': [3425], 'so': [3432], 'they': [3434], 'might': [3435], 'distinguished': [3437], 'MS/MS': [3440], 'level.': [3441], 'These': [3442, 4056], 'included': [3443], 'K18ac': [3444, 3760, 3890], 'K23ac;': [3446, 3762], 'K36me3': [3447, 3763], 'K27me2K36me1;': [3449, 3765], 'K27me3K36me2': [3450, 3766], 'K27me2K36me3;': [3452, 3768], 'K36me2S28pr,': [3453], 'quantified': [3456], 'detailed': [3458], 'below.': [3459], 'Area-under-the-curve': [3460], 'values': [3461], 'peaks': [3464, 3524, 3544, 3808], 'calculated': [3466], '"Fishtones"': [3469], 'program,': [3470], 'web': [3472], 'based': [3474], 'fishTones.js,': [3476], 'JavaScript': [3478], 'library': [3479, 3563], 'visualize': [3481], 'chromatography-tandem': [3483], 'experiments.': [3486], 'It': [3487], 'offers': [3488], 'features': [3492], 'graphical': [3494], 'widgets': [3495], 'including': [3496], 'ability': [3498], 'extract': [3500], 'chromatograms': [3502], 'multiple': [3504], 'simultaneously,': [3506], 'given': [3507], 'defined': [3511], 'derivatization/isotopic': [3514], 'conditions.': [3516], 'can': [3525, 4305], 'displayed': [3527], 'annotated': [3529], 'ions,': [3531], 'viewed': [3533], 'interactively': [3534], 'test': [3536], 'influence': [3538], 'hypothetical': [3540], 'user-selected': [3543], 'integrated': [3547, 3616], 'Designed': [3553], 'meet': [3555], 'challenges': [3557], 'analysis,': [3561], 'general': [3566], 'applicability': [3567], 'LC-MS': [3569], 'publicly': [3574], 'available': [3575], 'http://research-pub.gene.com/fishtones-js/howto.': [3577], 'those': [3579], 'combinations': [3580], 'co-eluting': [3586], 'identical': [3589, 3954, 4166], 'masses,': [3590], 'relative': [3592, 3785, 3833, 3887, 3900, 4153], 'abundance': [3593, 3834, 3888, 4132, 4152, 4194], 'derived': [3598], 'PTM-specific': [3600], 'chromatographic': [3609], 'peak,': [3610], 'full-mass': [3613], "scan's": [3615], 'peak': [3617, 3776, 3797, 4092], 'apportioned': [3619], 'accordingly': [3620], 'manner': [3623], 'previous': [3626], 'reports': [3627], '21Jung': [3660], 'H.R.': [3661], 'Pasini': [3662], 'Helin': [3664], 'Jensen': [3666], 'O.N.': [3667], 'Spectrometry': [3670], 'Histones': [3672], 'H3.2': [3673], 'H3.3': [3675], 'Suz12-deficient': [3677], 'Mouse': [3678], 'Embryonic': [3679], 'Stem': [3680], 'Cells': [3681], 'Reveals': [3682], 'Distinct,': [3683], 'Dynamic': [3684], 'Post-translational': [3685], 'Lys-27': [3688], 'Lys-36.Mol.': [3690], '9:': [3694], '838-850Abstract': [3695], '(113)': [3703], '22Phanstiel': [3706], 'Brumbaugh': [3708], 'Berggren': [3710], 'W.T.': [3711], 'Conard': [3712], 'Feng': [3714], 'X.': [3715], 'Levenstein': [3716], 'M.E.': [3717], 'McAlister': [3718], 'G.C.': [3719], 'Thomson': [3720], 'Coon': [3722], 'identifies': [3726], 'quantifies': [3728], '74': [3729], 'unique': [3730], 'isoforms': [3733], 'differentiating': [3735], 'embryonic': [3737], 'stem': [3738], 'cells.Proc.': [3739], 'Natl.': [3740], 'Acad.': [3741], 'U.S.A.': [3743], '105:': [3745], '4093-4098Crossref': [3746], '(142)': [3749], 'procedure': [3758], 'were:': [3759], 'K36me2S28pr': [3769], 'K27me3K36me2T32pr;': [3771], 'K27me2K36me3S28pr': [3772], 'K27me2K36me3T32pr.': [3774], 'Integrated': [3775], 'raw': [3780], 'converted': [3783, 4034], 'abundances': [3786, 3901], 'dividing': [3788], 'measured': [3790], 'sum': [3794], 'covering': [3799, 3809, 3873], 'sequence,': [3803], 'example,': [3805, 3869], 'if': [3806, 3870], '3–8': [3812], 'had': [3813, 4071], 'areas:': [3814], 'K4unmod,': [3815], '107counts;': [3818], 'K4me1,': [3819], '106counts;': [3822], 'K4me2': [3823, 3836], '105counts,': [3826, 3831], 'K4me3,': [3828], 'would': [3837, 3891], '105/1.13': [3841], '107': [3843], '=': [3844], '0.0177.': [3845], 'In': [3846, 4287], 'cases': [3847, 4201], 'where': [3848, 4186], 'present': [3854], 'single': [3857], 'peptide,': [3858, 4140], "peak's": [3860], 'contributes': [3862], 'taken': [3866, 4248], 'individually.': [3867], '18–26': [3876], 'yielded': [3877], 'peaks:': [3878], 'K18unK23un,': [3879], 'K18me1K23un,': [3880], 'K18acK23un,': [3881], 'K18unK23ac,': [3882], 'K18acK23ac,': [3884], '(K18acK23un': [3893], '+': [3894], 'K18acK23ac)/(sum': [3895], 'all).': [3897], 'Once': [3898], "peaks'": [3899], 'calculated,': [3906], 'measure': [3911], 'mark-by-mark': [3912], 'changes,': [3913], 'examplein': [3915], 'two-sample': [3917], '(chemical': [3919, 3930], 'labeled': [3920, 3931, 4015], 'SILAC),': [3922], 'common': [3927], 'internal': [3928, 3938], 'super-SILAC),': [3933], '(label': [3940], 'free).': [3941], 'Eight': [3942], 'corresponding': [3945], 'synthesized,': [3953], 'states': [3959], 'lysine-4': [3961], '(unmodified,': [3962], 'acetylated,': [3963], 'mono-/di-': [3964], 'tri-methylated),': [3966], 'and/or': [3967], 'phosphorylated': [3968], 'threonine-6.': [3970], 'Each': [3971], 'treated': [3976], 'published': [3979], 'protocols': [3980], 'isotopically': [4014], '(d10)': [4016], 'block': [4020, 4050], 'terminus': [4024], 'unmodified': [4027, 4139, 4156], 'lysines.': [4028], 'Monomethyl': [4029], 'K4': [4030], 'thereby': [4033], 'propionyl': [4037], 'Trypsin': [4039], 'peptides,': [4057], 'equimolar': [4060], 'ratios,': [4061], 'endogenous': [4065], '293T': [4068], 'identically': [4074], 'stable': [4077, 4102], 'labeling,': [4079], 'When': [4090], '-': [4098, 4105], 'distinguishable': [4099], 'labels': [4104], 'extracted,': [4107], 'it': [4108], 'evident': [4110], '"recoveries"': [4113], 'differently': [4115], 'quite': [4119], 'different': [4120, 4159], '(Fig.': [4121, 4298], '1A).': [4122], 'Whereas': [4123], 'versions': [4125], 'greater': [4136], 'phosphoryl,': [4144], 'dimethyl/phosphoryl': [4146], 'below': [4150], '10%': [4151], 'counterpart.': [4157], 'Although': [4158], 'expected': [4163], 'responses': [4167], 'spectrometer,': [4171], 'such': [4172], 'discrimination': [4176], 'could': [4181], 'confound': [4182], 'experiments,': [4184], 'form': [4189], 'begin': [4196], 'with,': [4197], 'H3K4me2': [4203], '-me3.': [4205], 'employed': [4210], 'determine': [4215], 'whether': [4216], 'variable': [4218], 'because': [4224], 'resistance': [4227], 'digestion,': [4229], 'instability': [4231], 'peptides.': [4235], 'A1-R17': [4238], 'trypsin,': [4245], '5,': [4252], '30-minute': [4256], 'points.': [4258, 4311], 'With': [4259], 'modification,': [4264], 'tryptic': [4265], 'cleavage': [4266], 'should': [4267], 'occur': [4268], 'arginines,': [4272], 'three': [4274], 'fully': [4275], 'processed': [4276], 'potentially': [4279], 'additional': [4281], 'partial': [4285], 'K4me3': [4296], '1B),': [4299], 'potential': [4303], 'observed': [4307], 'early': [4309], 'Within': [4312], 'mins': [4314], 'much': [4320], 'attenuated': [4321], 'pa': [4324]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2156806661', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 16}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 12}, {'year': 2015, 'cited_by_count': 3}], 'updated_date': '2024-12-14T05:27:35.505051', 'created_date': '2016-06-24'}