Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2156708180', 'doi': 'https://doi.org/10.1152/ajpendo.00669.2006', 'title': 'Nocturnal free fatty acids are uniquely elevated in the longitudinal development of diet-induced insulin resistance and hyperinsulinemia', 'display_name': 'Nocturnal free fatty acids are uniquely elevated in the longitudinal development of diet-induced insulin resistance and hyperinsulinemia', 'publication_year': 2007, 'publication_date': '2007-02-02', 'ids': {'openalex': 'https://openalex.org/W2156708180', 'doi': 'https://doi.org/10.1152/ajpendo.00669.2006', 'mag': '2156708180', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17264230'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpendo.00669.2006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196637695', 'display_name': 'AJP Endocrinology and Metabolism', 'issn_l': '0193-1849', 'issn': ['0193-1849', '1522-1555'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076100497', 'display_name': 'Stella P. Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1174212', 'display_name': 'University of Southern California', 'ror': 'https://ror.org/03taz7m60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1174212']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stella P Kim', 'raw_affiliation_strings': ['Department of Physiology and Biophysics, Keck School of Medicine of the University of Southern California, 1333 San Pablo St. MMR 626, Los Angeles, CA 90033, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Biophysics, Keck School of Medicine of the University of Southern California, 1333 San Pablo St. MMR 626, Los Angeles, CA 90033, USA.', 'institution_ids': ['https://openalex.org/I1174212']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076308026', 'display_name': 'Karyn J. Catalano', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Karyn J Catalano', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029177430', 'display_name': 'Isabel Hsu', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Isabel R Hsu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007005680', 'display_name': 'Jenny D. Chiu', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jenny D Chiu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067926928', 'display_name': 'Joyce M. Richey', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Joyce M Richey', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5030791389', 'display_name': 'Richard N. Bergman', 'orcid': 'https://orcid.org/0000-0003-1539-4471'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Richard N Bergman', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.871, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 88, 'citation_normalized_percentile': {'value': 0.999504, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '292', 'issue': '6', 'first_page': 'E1590', 'last_page': 'E1598'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10489', 'display_name': 'Regulation of Appetite and Obesity', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10489', 'display_name': 'Regulation of Appetite and Obesity', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10528', 'display_name': 'Adipokines, Inflammation, and Metabolic Diseases', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hyperinsulinemia', 'display_name': 'Hyperinsulinemia', 'score': 0.974164}], 'concepts': [{'id': 'https://openalex.org/C2780988686', 'wikidata': 'https://www.wikidata.org/wiki/Q14375936', 'display_name': 'Hyperinsulinemia', 'level': 4, 'score': 0.974164}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.9265448}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.9151758}, {'id': 'https://openalex.org/C2777391703', 'wikidata': 'https://www.wikidata.org/wiki/Q1053470', 'display_name': 'Insulin resistance', 'level': 3, 'score': 0.84719944}, {'id': 'https://openalex.org/C2778199505', 'wikidata': 'https://www.wikidata.org/wiki/Q2992990', 'display_name': 'Postprandial', 'level': 3, 'score': 0.7395946}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.655314}, {'id': 'https://openalex.org/C2777368190', 'wikidata': 'https://www.wikidata.org/wiki/Q477390', 'display_name': 'Hyperinsulinism', 'level': 4, 'score': 0.47599828}, {'id': 'https://openalex.org/C511355011', 'wikidata': 'https://www.wikidata.org/wiki/Q12174', 'display_name': 'Obesity', 'level': 2, 'score': 0.43124872}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36906034}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3542633}], 'mesh': [{'descriptor_ui': 'D002940', 'descriptor_name': 'Circadian Rhythm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004032', 'descriptor_name': 'Diet', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005230', 'descriptor_name': 'Fatty Acids, Nonesterified', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D006946', 'descriptor_name': 'Hyperinsulinism', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': True}, {'descriptor_ui': 'D006946', 'descriptor_name': 'Hyperinsulinism', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D007333', 'descriptor_name': 'Insulin Resistance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001823', 'descriptor_name': 'Body Composition', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002096', 'descriptor_name': 'C-Peptide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002096', 'descriptor_name': 'C-Peptide', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005215', 'descriptor_name': 'Fasting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005215', 'descriptor_name': 'Fasting', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D005230', 'descriptor_name': 'Fatty Acids, Nonesterified', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052216', 'descriptor_name': 'Glucagon-Like Peptide 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052216', 'descriptor_name': 'Glucagon-Like Peptide 1', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D005990', 'descriptor_name': 'Glycerol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005990', 'descriptor_name': 'Glycerol', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D006728', 'descriptor_name': 'Hormones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006728', 'descriptor_name': 'Hormones', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D006946', 'descriptor_name': 'Hyperinsulinism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006946', 'descriptor_name': 'Hyperinsulinism', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014280', 'descriptor_name': 'Triglycerides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014280', 'descriptor_name': 'Triglycerides', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpendo.00669.2006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196637695', 'display_name': 'AJP Endocrinology and Metabolism', 'issn_l': '0193-1849', 'issn': ['0193-1849', '1522-1555'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17264230', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.6}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1498897377', 'https://openalex.org/W1963481139', 'https://openalex.org/W1970622371', 'https://openalex.org/W1981261500', 'https://openalex.org/W1987309306', 'https://openalex.org/W1991688216', 'https://openalex.org/W1992609447', 'https://openalex.org/W1995448901', 'https://openalex.org/W1997079833', 'https://openalex.org/W1998009398', 'https://openalex.org/W1998022956', 'https://openalex.org/W2010965342', 'https://openalex.org/W2011874540', 'https://openalex.org/W2024886296', 'https://openalex.org/W2029036505', 'https://openalex.org/W2039462528', 'https://openalex.org/W2044482587', 'https://openalex.org/W2053707022', 'https://openalex.org/W2058428175', 'https://openalex.org/W2064052128', 'https://openalex.org/W2067132822', 'https://openalex.org/W2068912594', 'https://openalex.org/W2073446075', 'https://openalex.org/W2077149049', 'https://openalex.org/W2079246886', 'https://openalex.org/W2082995727', 'https://openalex.org/W2086946222', 'https://openalex.org/W2094317193', 'https://openalex.org/W2098232314', 'https://openalex.org/W2104680343', 'https://openalex.org/W2106931189', 'https://openalex.org/W2107767863', 'https://openalex.org/W2108916652', 'https://openalex.org/W2116656512', 'https://openalex.org/W2119571022', 'https://openalex.org/W2122334779', 'https://openalex.org/W2122726077', 'https://openalex.org/W2130001481', 'https://openalex.org/W2135666165', 'https://openalex.org/W2141569406', 'https://openalex.org/W2146698746', 'https://openalex.org/W2157513821', 'https://openalex.org/W2162261303', 'https://openalex.org/W2166439032', 'https://openalex.org/W2181752507', 'https://openalex.org/W2181817569', 'https://openalex.org/W2187233472', 'https://openalex.org/W2410789805', 'https://openalex.org/W2415852409', 'https://openalex.org/W2422651944'], 'related_works': ['https://openalex.org/W92332735', 'https://openalex.org/W2983614893', 'https://openalex.org/W2420185505', 'https://openalex.org/W2410952378', 'https://openalex.org/W2406554937', 'https://openalex.org/W2401139202', 'https://openalex.org/W2033704972', 'https://openalex.org/W2026880258', 'https://openalex.org/W1988879418', 'https://openalex.org/W1980928521'], 'abstract_inverted_index': {'Obesity': [0], 'is': [1, 56, 66], 'strongly': [2], 'associated': [3], 'with': [4], 'hyperinsulinemia': [5, 114, 143, 210], 'and': [6, 71, 82, 93, 112, 142, 151, 208], 'insulin': [7, 35, 69, 77, 110, 140, 206], 'resistance,': [8], 'both': [9, 109, 149], 'primary': [10], 'risk': [11], 'factors': [12], 'for': [13, 31, 50, 203], 'type': [14], '2': [15], 'diabetes.': [16], 'It': [17], 'has': [18], 'been': [19], 'thought': [20], 'that': [21, 105, 126, 185], 'increased': [22], 'fasting': [23, 76, 80, 159, 171, 209], 'free': [24], 'fatty': [25], 'acids': [26], '(FFA)': [27], 'may': [28, 200], 'be': [29, 201], 'responsible': [30, 202], 'the': [32, 62, 86, 180, 212], 'development': [33, 67, 137, 204], 'of': [34, 68, 90, 130, 138, 148, 183, 190, 205], 'resistance': [36, 70, 111, 141, 207], 'during': [37], 'obesity,': [38], 'causing': [39], 'an': [40], 'increase': [41, 74, 178], 'in': [42, 61, 75, 120, 157, 170, 179, 211], 'plasma': [43, 88], 'glucose': [44, 160], 'levels,': [45], 'which': [46], 'would': [47], 'then': [48], 'signal': [49], 'compensatory': [51, 113], 'hyperinsulinemia.': [52], 'But': [53], 'when': [54], 'obesity': [55], 'induced': [57, 115], 'by': [58, 116], 'fat': [59, 153, 191], 'feeding': [60], 'dog': [63, 214], 'model,': [64], 'there': [65, 135, 166, 173], 'a': [72, 117, 131, 155, 175, 188], 'marked': [73], 'despite': [78], 'constant': [79], 'FFA': [81, 184], 'glucose.': [83, 163], 'We': [84, 124], 'examined': [85], '24-h': [87], 'profiles': [89], 'FFA,': [91, 172, 196], 'glucose,': [92, 199], 'other': [94], 'hormones': [95], 'to': [96, 108], 'observe': [97], 'any': [98], 'potential': [99], 'longitudinal': [100], 'postprandial': [101, 162], 'or': [102, 161], 'nocturnal': [103, 181, 195], 'alterations': [104], 'could': [106], 'lead': [107], 'high-fat': [118], 'diet': [119], 'eight': [121], 'normal': [122], 'dogs.': [123], 'found': [125], 'after': [127], '6': [128], 'wk': [129], 'high-fat,': [132], 'hypercaloric': [133], 'diet,': [134], 'was': [136, 167, 174], 'significant': [139, 177], 'as': [144, 146, 187], 'well': [145], 'accumulation': [147], 'subcutaneous': [150], 'visceral': [152], 'without': [154], 'change': [156, 169], 'either': [158], 'Moreover,': [164], 'although': [165], 'no': [168], 'highly': [176], 'levels': [182], 'occurred': [186], 'result': [189], 'feeding.': [192], 'Thus': [193], 'enhanced': [194], 'but': [197], 'not': [198], 'fat-fed': [213], 'model.': [215]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2156708180', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-13T17:49:09.868597', 'created_date': '2016-06-24'}