Publication Information

{'id': 'https://openalex.org/W2156211472', 'doi': 'https://doi.org/10.1074/jbc.275.11.7723', 'title': 'PRMT1 Is the Predominant Type I Protein Arginine Methyltransferase in Mammalian Cells', 'display_name': 'PRMT1 Is the Predominant Type I Protein Arginine Methyltransferase in Mammalian Cells', 'publication_year': 2000, 'publication_date': '2000-03-01', 'ids': {'openalex': 'https://openalex.org/W2156211472', 'doi': 'https://doi.org/10.1074/jbc.275.11.7723', 'mag': '2156211472', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10713084'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.275.11.7723', 'pdf_url': 'http://www.jbc.org/article/S0021925818302710/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925818302710/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5011614759', 'display_name': 'Jie Tang', 'orcid': 'https://orcid.org/0000-0001-7882-4462'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jie Tang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000864648', 'display_name': 'Adam Frankel', 'orcid': 'https://orcid.org/0000-0002-9069-4653'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Adam Frankel', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110700757', 'display_name': 'Robert Cook', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Robert J. 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4754, 4823, 4840, 4898, 4993, 5086, 5168, 5187, 5204, 5345, 5466, 5650, 5660, 5720, 5805, 5852, 5855, 5865, 5868, 5875, 5885, 5903], 'asymmetric': [9, 218, 540, 5869], 'ω-N': [10, 219, 541, 713], 'G,N': [11, 220, 542], 'G-dimethylarginine': [12, 221], 'residues': [13, 24, 222, 233, 510, 795, 1340, 4200], 'by': [14, 223, 1632, 1967, 1972, 2018, 2236, 2250, 2292, 2345, 2387, 2453, 2623, 2753, 3167, 3312, 3692, 3826, 3883, 3891, 4017, 4023, 4094, 4373, 4383, 4391, 4414, 5293, 5832], 'transferring': [15, 224], 'methyl': [16, 225, 500, 4194], 'groups': [17, 21, 226, 230, 501, 4195], 'fromS-adenosyl-l-methionine': [18, 227, 502], 'to': [19, 85, 185, 228, 294, 394, 504, 970, 1053, 1111, 1409, 1486, 1650, 1660, 1915, 1940, 2022, 2461, 2564, 2633, 2706, 2717, 2964, 3032, 3041, 3298, 3430, 3501, 3862, 4184, 4198, 4245, 4254, 4284, 4315, 4324, 4328, 4360, 4367, 4438, 5093, 5199, 5210, 5222, 5253, 5275, 5427, 5463, 5862], 'guanidino': [20, 229, 506], 'in': [25, 39, 75, 79, 127, 204, 234, 248, 284, 288, 336, 413, 448, 512, 583, 782, 956, 972, 1009, 1050, 1107, 1280, 1341, 1613, 1639, 1923, 1961, 2135, 2177, 2182, 2201, 2390, 2509, 2577, 2578, 2585, 2594, 2612, 2679, 2825, 2898, 2899, 2940, 2970, 2997, 3013, 3086, 3110, 3248, 3282, 3292, 3363, 3376, 3506, 3540, 3560, 3571, 3629, 3649, 3667, 3685, 3708, 3838, 3851, 3865, 3876, 3919, 4045, 4070, 4127, 4162, 4201, 4337, 4408, 4418, 4608, 4677, 4681, 4725, 4746, 4830, 4998, 5107, 5208, 5227, 5283, 5313, 5473, 5515, 5826], 'a': [26, 43, 51, 235, 252, 260, 963, 975, 1059, 1275, 1281, 1444, 1492, 1567, 1633, 1709, 1973, 2437, 2847, 2884, 3307, 3323, 3458, 4181, 4249, 4260, 4470, 4590, 4612, 4736, 4990, 5095, 5108, 5255, 5271, 5484], 'variety': [27, 236], 'eucaryotic': [29, 238], 'proteins.': [30, 239], 'The': [31, 240, 777, 1764, 2185, 2190, 2245, 2359, 2381, 2430, 2538, 2567, 2638, 2690, 2710, 2729, 2842, 3372, 3394, 3591, 3682, 3798, 3817, 3835, 3873, 4050, 4125, 4397, 4527, 4580, 4750, 5141, 5277, 5718, 5800], 'predominant': [32, 241, 1571, 1947, 2781, 2848, 3246, 3290, 3552, 3567, 4466, 4595, 4900, 4995, 5001, 5105, 5236, 5331, 5470], 'type': [33, 90, 196, 242, 299, 405, 579, 756, 778, 821, 952, 1919, 1948, 4422, 4670, 4825, 4901, 5169, 5542, 5776, 5786, 5877], 'enzyme': [35, 201, 244, 410, 1637, 1963, 1970, 3016, 3320, 3850, 4031], 'activity': [36, 58, 64, 74, 93, 122, 141, 202, 245, 267, 273, 283, 302, 331, 350, 411, 760, 1199, 1436, 1449, 1960, 1980, 2168, 2339, 2819, 2824, 2917, 2930, 2939, 2968, 2996, 3012, 3044, 3084, 3421, 3463, 3505, 3585, 3684, 3705, 3794, 3800, 3859, 3875, 3887, 3918, 3994, 4007, 4032, 4161, 4468, 4709, 4745, 4829, 4905, 5149, 5156, 5173, 5226, 5492, 5649], 'is': [37, 246, 750, 967, 1004, 1443, 1945, 1965, 2870, 2896, 2923, 2946, 3166, 3288, 3387, 3427, 3499, 3516, 3550, 3565, 3706, 3823, 4058, 4469, 4761, 4989, 5091, 5246, 5267, 5273, 5655, 5811, 5815, 5830], 'found': [38, 247, 3864], 'mammalian': [40, 205, 249, 414, 513, 912, 1051, 1483, 5516, 5782, 5818], 'cells': [41, 77, 206, 250, 286, 415, 514, 913, 1052, 1108, 1924, 1931, 2207, 2582, 3114, 3294, 3314, 4679, 4711, 4747, 4831, 5284, 5517, 5783, 5819], 'as': [42, 61, 251, 270, 1058, 1491, 1616, 1708, 2047, 2142, 2180, 2252, 2290, 2342, 2406, 2469, 2643, 2734, 2750, 2779, 2904, 2959, 2961, 3180, 3244, 3402, 3404, 3959, 4620, 4715, 5009, 5103, 5234, 5339, 5468, 5494, 5725, 5732], 'high': [44, 253], 'molecular': [45, 254, 4585, 4613, 4752, 4838, 4896, 5343], 'weight': [46, 255, 4586, 4614, 4839, 4897], 'complex': [47, 256, 1283, 3399, 3408, 4472, 4532, 4757, 4843, 5272], '(300–400': [48, 257], 'kDa).': [49, 258], 'In': [50, 134, 259, 343, 1566, 2514, 3003, 3061, 3099, 3520, 3716, 3930, 4028, 4301, 4538, 4589, 4657, 5534], 'previous': [52, 261, 3101], 'study,': [53, 262, 1569, 4540, 4593, 4660], 'this': [54, 263, 1614, 2826, 3364, 3931, 4531, 4624, 4658, 5266], 'methyltransferase': [57, 92, 166, 200, 266, 301, 375, 409, 441, 495, 759, 883, 916, 1435, 1485, 1628, 1883, 1944, 1952, 1959, 2744, 2783, 2823, 2938, 2995, 3174, 3287, 3302, 3326, 3492, 3504, 3556, 3570, 3584, 3647, 3663, 3858, 3978, 4011, 4079, 4160, 4188, 4598, 4674, 5004, 5225], 'was': [59, 268, 450, 1056, 1402, 1489, 1574, 1984, 1996, 2016, 2133, 2169, 2188, 2340, 2385, 2404, 2631, 2641, 2693, 2713, 2732, 2748, 2776, 2890, 3242, 3594, 4427, 4602, 4618, 5101, 5231], 'identified': [60, 269, 1403, 1609, 3104, 4619, 5102], 'an': [62, 271, 1005, 1636], 'additional': [63, 272, 5821], '10-formyltetrahydrofolate': [66, 275, 435, 1617, 1648], 'dehydrogenase': [67, 276, 436, 1618, 1849, 4262], '(FDH)': [68, 277], 'protein.': [69, 278], 'However,': [70, 279, 962, 1877, 2914, 3443, 5260, 5476, 5646], 'immunodepletion': [71, 112, 280, 321, 4816, 5294], 'FDH': [73, 86, 152, 173, 282, 295, 361, 382, 1642, 1702, 1766, 1878, 1910, 1962, 1969, 2141, 2338, 2403, 2433, 2775, 2818, 2834, 2843, 2857, 2894, 2921, 2943, 2950, 2972, 3000, 3015, 3043, 3047, 3059, 3068, 3080, 3089, 3097, 3241, 3358, 3525, 3564, 3762, 3766, 3793, 3799, 3815, 3849, 3886, 3898, 3991, 4030, 4177, 4287, 4306, 4352, 4403, 4734, 5090, 5100, 5155, 5195, 5217, 5250, 5291, 5301, 5335, 5467, 5479, 5505], 'RAT1': [76, 132, 143, 285, 341, 352, 2206, 2581, 2646, 3112, 3293, 3309, 3366, 3379, 3561, 4678, 4691], 'and': [78, 148, 159, 171, 207, 287, 357, 368, 380, 416, 539, 551, 559, 603, 711, 880, 914, 1015, 1068, 1097, 1190, 1195, 1337, 1343, 1350, 1531, 1541, 1653, 1662, 1664, 1845, 1909, 1925, 1932, 1937, 1953, 2042, 2101, 2176, 2241, 2378, 2463, 2504, 2522, 2533, 2553, 2560, 2610, 2628, 2715, 2820, 2957, 3022, 3034, 3074, 3079, 3108, 3295, 3352, 3359, 3413, 3450, 3528, 3639, 3642, 3714, 3723, 3760, 3772, 3916, 3925, 3940, 3945, 3956, 3967, 3973, 3983, 3993, 4036, 4047, 4066, 4084, 4139, 4149, 4168, 4242, 4282, 4288, 4295, 4307, 4317, 4326, 4334, 4363, 4380, 4399, 4404, 4562, 4604, 4680, 4712, 4832, 4834, 5177, 5182, 5184, 5192, 5249, 5302, 5334, 5423, 5549, 5633, 5642, 5722, 5738, 5745, 5797, 5837, 5843, 5872, 5888, 5910], 'murine': [80, 145, 289, 354, 2285, 4682], 'tissue': [81, 146, 290, 355, 2708, 5160], 'extracts': [82, 128, 155, 291, 337, 364, 2287, 3786, 4145, 5161], 'with': [83, 113, 292, 322, 974, 1062, 1193, 1229, 1451, 1495, 2500, 2520, 2547, 2562, 2608, 2614, 2746, 2872, 2949, 3315, 3350, 3409, 3436, 3700, 4064, 4293, 4311, 4332, 4611, 5790], 'antibody': [84, 115, 137, 293, 324, 346, 2132, 2977, 2986, 3006, 3031, 3040, 3054, 3064, 3694, 3763, 3832, 4020, 4702], 'does': [87, 116, 296, 325, 1879, 3065, 3846, 4178, 4703, 5196, 5218, 5487], 'not': [88, 117, 179, 297, 326, 388, 1880, 2877, 3066, 3475, 3677, 3740, 3796, 3807, 3847, 4022, 4060, 4166, 4179, 4351, 4390, 4534, 4704, 5197, 5219, 5488, 5812], 'diminish': [89, 298], 'toward': [94, 303], 'methyl-accepting': [96, 305, 2191, 2906, 3182, 3960, 4723, 5733], 'substrates': [97, 306, 546, 2192, 3384, 3539, 3558, 3961, 4716, 4724, 5654, 5854], 'glutathione': [98, 307], 'S-transferase': [99, 308], 'fibrillarin': [100, 309, 423], 'glycine': [101, 310], 'domain': [103, 312, 425, 1819, 1851], 'fusion': [104, 313, 426], 'or': [106, 315, 1971, 1991, 2197, 2466, 3483, 3673, 3731, 3747, 3811, 3997, 4025, 4688, 4720, 4748, 5279, 5305], 'heterogeneous': [107, 316, 431], 'nuclear': [108, 317, 432, 556, 606, 1010, 1277], 'ribonucleoprotein': [109, 318, 433], 'A1.': [110, 319, 3985], 'Similarly,': [111, 320], 'anti-FDH': [114, 323, 2976, 3030, 3039, 3075, 3353, 3414, 3480, 3725, 3831, 3893, 4024], 'remove': [118, 139, 327, 348, 2565, 2707], 'endogenous': [120, 329, 3325, 3373, 3553, 4722, 5490], 'methylating': [121, 330], 'for': [123, 332, 755, 1440, 2174, 2395, 2498, 2529, 2544, 2557, 2601, 2700, 2723, 3557, 4143, 4156, 4298, 4684, 5652, 5891, 5905], 'hypomethylated': [124, 333, 2198, 3308, 3365, 3378, 3441, 3508, 4690, 4726], 'proteins': [125, 334, 449, 584, 607, 1349, 1352, 2199, 2247, 2447, 2569, 2862, 4202, 4309, 5292, 5336, 5729], 'present': [126, 203, 335, 412, 2200, 2969, 3085, 3362, 3375, 3559], 'from': [129, 142, 156, 338, 351, 365, 911, 919, 1019, 1576, 1704, 1934, 1986, 1998, 2203, 2738, 2784, 3045, 3095, 3422, 3575, 3588, 3637, 3671, 3744, 3768, 3773, 3787, 3922, 3937, 3970, 4052, 4081, 4196, 4599, 4710, 5154, 5162, 5240, 5290, 5483], 'adenosine': [130, 339, 437, 2204], 'dialdehyde-treated': [131, 340, 2205], 'cells.': [133, 342, 3562], 'contrast,': [135, 344, 3004, 3062, 3521, 3717, 4029], 'anti-PRMT1': [136, 345, 3005, 3063, 3073, 3351, 3453, 3470, 3497, 3693, 3701, 3884, 4019], 'can': [138, 182, 347, 391, 1109, 2828, 2992, 3092, 3456, 3488, 3689, 3879, 3888, 4013, 4280, 4357, 4369, 5150, 5285, 5480], 'PRMT1': [140, 192, 349, 401, 828, 1194, 1226, 1410, 1454, 2100, 2956, 3078, 3165, 3360, 3549, 3908, 4345, 4366, 4665, 4760, 4820, 4842, 4988, 5008, 5248, 5632, 5651, 5721, 5735, 5836], 'extracts,': [144, 147, 353, 356], 'purified': [149, 180, 358, 389, 1575, 1703, 2046, 2138, 2432, 2778, 2893, 2920, 2932, 2942, 2999, 3088, 5194, 5233, 5482], 'rat': [150, 359, 1577, 1705, 1930, 2139, 2785, 3249, 4600, 5241, 5474, 5912], 'liver': [151, 360, 1578, 1706, 2140, 2286, 2402, 2786, 3250, 3635, 3652, 3669, 3687, 3750, 3770, 3867, 3878, 3968, 3987, 4144, 4601, 5913], 'preparations.': [153, 362], 'Tissue': [154, 363], 'FDH(+/+),': [157, 366, 1935, 3923, 3943, 3971], 'FDH(+/−),': [158, 367, 1936, 3924, 3944, 3972, 4083, 4148], 'FDH(−/−)': [160, 369, 1938, 3576, 3592, 3623, 3640, 3674, 3748, 3788, 3844, 3926, 3946, 3974, 4163, 5163], 'mice': [161, 370, 1939, 3577, 3624, 3641, 3675, 3789, 3927, 3975, 4164, 5164, 5909], 'have': [162, 371, 825, 3176, 3625, 3976, 4003, 4321, 4434, 4462, 5310, 5489, 5551, 5839], 'similar': [163, 372, 3861, 3977], 'activities': [167, 376, 497, 3648, 3664, 3743, 3767, 3950, 3979, 4012, 4069, 4080, 5282, 5719, 5792], 'but': [168, 178, 377, 387, 1975, 3474, 3806, 3895, 4021, 4350, 4389, 5553, 5793], 'high,': [169, 378], 'intermediate,': [170, 379], 'undetectable': [172, 381], 'activities,': [174, 383], 'respectively.': [175, 384, 4152], 'Recombinant': [176, 385, 2039], 'glutathioneS-transferase-PRMT1,': [177, 386], 'FDH,': [181, 390, 2958, 3036, 4061, 4259, 4621], 'be': [183, 392, 1054, 1487, 1630, 2829, 3093, 3690, 3881, 3889, 4015, 4358, 4370, 4627, 5094, 5151, 5286, 5481], 'cross-linked': [184, 393, 4297, 4310, 4359], 'methyl-donor': [187, 396, 2186, 5202], 'substrateS-adenosyl-l-methionine.': [188, 397], 'We': [189, 398, 1927, 3070, 3304, 3904, 4072, 4233, 4247, 5881, 5894], 'conclude': [190, 399, 3071, 4986], 'that': [191, 400, 498, 1452, 1543, 1623, 3072, 3321, 3356, 3548, 3803, 4056, 4062, 4176, 4236, 4320, 4464, 4623, 4664, 4733, 4758, 4819, 4987, 5089, 5247, 5264, 5486, 5504, 5539, 5659, 5817, 5824, 5835], 'contributes': [193, 402, 3296, 3909, 4666, 4735, 4821], 'major': [195, 404, 1611, 1625, 1918, 2438, 4182, 4606, 5011], 'tissues.': [208, 417, 1926, 2740, 4071, 4749, 4999], 'N-methyltransferase': [420, 1049, 4744, 5239, 5859], 'S-adenosyl-l-methionine': [421, 2747], 'glutathioneS-transferase': [422], 'glycine-arginine': [424], 'polyacrylamide': [428], 'gel': [429, 2015, 2442, 2450, 2869], 'electrophoresis': [430], '10-formyl-5,6,7,8-tetrahydrofolate': [434], 'dialdehyde': [438], 'coactivator-associated': [439, 881], '1': [442, 884, 3021, 3658], 'phosphate-buffered': [443, 2680], 'saline': [444, 2681], 'S-adenosylhomocysteine': [445], 'Arginine': [446], 'methylation': [447, 582, 3514, 3535, 4426, 5536, 5871], 'discovered': [451, 781, 1057, 4428], 'over': [452, 4429], '30': [453, 2724, 4430], 'years': [454, 4431], 'ago': [455], '(1.Paik': [456], 'W.K.': [457, 473, 520, 718, 1586, 2303, 2794, 3258, 4104, 4479, 4499, 4636, 4909, 4931, 4957, 5024, 5046, 5071, 5120, 5437], 'Kim': [458, 474, 517, 719, 2293, 4095, 4480, 4500, 4910, 4958, 5025, 5072], 'S.': [459, 475, 518, 564, 611, 720, 764, 801, 836, 861, 930, 1077, 1207, 1294, 1318, 1356, 1460, 1554, 1580, 1889, 2057, 2081, 2112, 2213, 2260, 2297, 2477, 2656, 2788, 3122, 3146, 3189, 3252, 3610, 4098, 4206, 4220, 4446, 4481, 4501, 4630, 4771, 4795, 4851, 4875, 4911, 4925, 4959, 5026, 5040, 5073, 5114, 5355, 5431, 5521, 5564, 5588, 5667], 'J.': [460, 629, 633, 649, 652, 721, 738, 802, 839, 857, 864, 931, 1080, 1132, 1136, 1170, 1210, 1239, 1243, 1259, 1262, 1297, 1314, 1321, 1376, 1385, 1456, 1463, 1591, 1676, 1721, 1738, 1779, 1801, 1829, 1861, 2060, 2077, 2084, 2108, 2115, 2151, 2209, 2216, 2256, 2263, 2308, 2473, 2480, 2659, 2799, 3125, 3142, 3149, 3185, 3192, 3215, 3224, 3263, 3329, 3336, 4109, 4482, 4503, 4641, 4774, 4791, 4798, 4854, 4871, 4878, 4912, 4936, 4961, 5027, 5051, 5075, 5125, 5358, 5380, 5397, 5442, 5567, 5584, 5591, 5663, 5670, 5693, 5702], 'Biol.': [461, 570, 617, 671, 722, 770, 803, 840, 865, 932, 1081, 1211, 1298, 1322, 1362, 1386, 1464, 1592, 1677, 1722, 1780, 1802, 1830, 1862, 2061, 2085, 2116, 2152, 2217, 2264, 2309, 2481, 2660, 2800, 3126, 3150, 3193, 3225, 3264, 3337, 4110, 4212, 4224, 4452, 4483, 4518, 4571, 4642, 4775, 4799, 4855, 4879, 4913, 4937, 4976, 5028, 5052, 5126, 5359, 5381, 5443, 5527, 5568, 5592, 5671, 5703], 'Chem.': [462, 723, 804, 841, 866, 933, 1082, 1212, 1299, 1323, 1387, 1465, 1593, 1678, 1723, 1781, 1803, 1831, 1863, 2062, 2086, 2117, 2153, 2218, 2265, 2310, 2482, 2661, 2801, 3127, 3151, 3194, 3226, 3265, 3338, 4111, 4484, 4643, 4776, 4800, 4856, 4880, 4914, 4938, 5029, 5053, 5127, 5360, 5382, 5444, 5569, 5593, 5672, 5704], '1968;': [463], '243:': [464], '2108-2114Abstract': [465], 'Full': [466, 727, 808, 810, 845, 847, 870, 872, 937, 939, 1086, 1088, 1216, 1218, 1303, 1305, 1327, 1329, 1391, 1393, 1469, 1471, 1597, 1599, 1682, 1727, 1785, 1807, 1835, 1837, 1867, 1869, 2066, 2068, 2090, 2092, 2121, 2123, 2157, 2159, 2222, 2224, 2269, 2271, 2314, 2316, 2486, 2488, 2665, 2667, 2805, 2807, 3131, 3133, 3155, 3157, 3198, 3200, 3230, 3232, 3269, 3271, 3342, 4115, 4117, 4488, 4647, 4649, 4780, 4782, 4804, 4806, 4860, 4862, 4884, 4886, 4918, 4942, 4944, 5033, 5057, 5059, 5131, 5133, 5364, 5366, 5386, 5448, 5450, 5573, 5575, 5597, 5599, 5676, 5678, 5708, 5710], 'Text': [467, 728, 809, 811, 846, 848, 871, 873, 938, 940, 1087, 1089, 1217, 1219, 1304, 1306, 1328, 1330, 1392, 1394, 1470, 1472, 1598, 1600, 1683, 1728, 1786, 1808, 1836, 1838, 1868, 1870, 2067, 2069, 2091, 2093, 2122, 2124, 2158, 2160, 2223, 2225, 2270, 2272, 2315, 2317, 2487, 2489, 2666, 2668, 2806, 2808, 3132, 3134, 3156, 3158, 3199, 3201, 3231, 3233, 3270, 3272, 3343, 4116, 4118, 4489, 4648, 4650, 4781, 4783, 4805, 4807, 4861, 4863, 4885, 4887, 4919, 4943, 4945, 5034, 5058, 5060, 5132, 5134, 5365, 5367, 5387, 5449, 5451, 5574, 5576, 5598, 5600, 5677, 5679, 5709, 5711], 'PDF': [468, 729, 812, 849, 874, 941, 1090, 1220, 1307, 1331, 1395, 1473, 1601, 1684, 1729, 1787, 1809, 1839, 1871, 2070, 2094, 2125, 2161, 2226, 2273, 2318, 2490, 2669, 2809, 3135, 3159, 3202, 3234, 3273, 3344, 4119, 4490, 4651, 4784, 4808, 4864, 4888, 4920, 4946, 5035, 5061, 5135, 5368, 5388, 5452, 5577, 5601, 5680, 5712], 'PubMed': [469, 483, 525, 574, 621, 637, 659, 676, 698, 730, 742, 774, 813, 850, 875, 906, 942, 998, 1039, 1091, 1140, 1184, 1221, 1247, 1269, 1308, 1332, 1366, 1396, 1427, 1474, 1522, 1561, 1602, 1685, 1697, 1730, 1742, 1759, 1788, 1810, 1840, 1872, 1896, 2034, 2071, 2095, 2126, 2162, 2227, 2274, 2319, 2333, 2354, 2418, 2491, 2670, 2770, 2810, 3136, 3160, 3203, 3235, 3274, 3345, 3615, 4120, 4216, 4228, 4275, 4456, 4491, 4507, 4522, 4575, 4652, 4785, 4809, 4865, 4889, 4921, 4947, 4965, 4980, 5036, 5062, 5079, 5136, 5369, 5389, 5401, 5418, 5453, 5531, 5578, 5602, 5627, 5681, 5713, 5767], 'Google': [470, 486, 528, 575, 622, 640, 662, 679, 701, 731, 745, 775, 816, 853, 878, 909, 945, 1001, 1042, 1094, 1143, 1187, 1224, 1250, 1272, 1311, 1335, 1367, 1399, 1430, 1477, 1525, 1564, 1605, 1686, 1700, 1731, 1745, 1762, 1789, 1811, 1843, 1875, 1899, 2037, 2074, 2098, 2129, 2165, 2230, 2277, 2322, 2336, 2357, 2421, 2494, 2673, 2773, 2813, 3139, 3163, 3206, 3238, 3277, 3346, 3618, 4123, 4217, 4231, 4278, 4457, 4492, 4510, 4525, 4578, 4655, 4788, 4812, 4868, 4892, 4922, 4950, 4968, 4983, 5037, 5065, 5082, 5139, 5372, 5390, 5404, 5421, 5456, 5532, 5581, 5605, 5630, 5684, 5716, 5770], 'Scholar,': [471, 623, 641, 663, 680, 732, 1144, 1251, 1312, 1368, 1732, 1746, 1790, 2075, 2323, 3140, 3207, 4218, 4493, 4511, 4789, 4869, 4923, 4951, 4969, 5038, 5373, 5391, 5405, 5582, 5606, 5685], '2.Paik': [472], 'Biochem.': [476, 737, 1556, 1692, 1737, 1891, 2763, 5396], 'Biophys.': [477, 1557, 1693, 1754, 1892, 2764, 4270, 5413], 'Res.': [478, 568, 615, 655, 768, 1265, 1360, 2765, 4210, 4450, 5525], 'Commun.': [479, 2766], '1967;': [480], '29:': [481], '14-20Crossref': [482], 'Scopus': [484, 526, 638, 660, 677, 699, 743, 814, 851, 876, 907, 943, 999, 1040, 1092, 1141, 1185, 1222, 1248, 1270, 1309, 1333, 1397, 1428, 1475, 1523, 1562, 1603, 1698, 1743, 1760, 1841, 1873, 1897, 2035, 2072, 2096, 2127, 2163, 2228, 2275, 2320, 2334, 2355, 2419, 2492, 2671, 2771, 2811, 3137, 3161, 3204, 3236, 3275, 3616, 4121, 4229, 4276, 4508, 4523, 4576, 4653, 4786, 4810, 4866, 4890, 4948, 4966, 4981, 5063, 5080, 5137, 5370, 5402, 5419, 5454, 5579, 5603, 5628, 5682, 5714, 5768], '(121)': [485], 'Scholar).': [487, 529, 576, 702, 746, 776, 817, 946, 1002, 1043, 1095, 1188, 1225, 1273, 1400, 1431, 1478, 1526, 1565, 1606, 1701, 1763, 1876, 1900, 2038, 2099, 2130, 2166, 2231, 2278, 2337, 2358, 2495, 2674, 2774, 2814, 3164, 3239, 3347, 3619, 4124, 4232, 4458, 4526, 4579, 4656, 4813, 5083, 5140, 5457, 5533, 5631, 5717, 5771], 'At': [488], 'least': [489, 4546], 'two': [490, 3105, 4001], 'types': [491], 'arginineN-': [494], '(PRMT)1': [496], 'transfer': [499, 4193], '(AdoMet)': [503], 'group': [507], 'exist': [511, 5514], '(3.Lee': [515], 'H.W.': [516], 'Paik': [519, 717, 1585, 2302, 2793, 3257, 4103, 4478, 4498, 4635, 4908, 4930, 4956, 5023, 5045, 5070, 5119, 5436], 'Biochemistry.': [521], '1977;': [522], '16:': [523, 635, 1245], '78-85Crossref': [524], '(74)': [527], 'PRMT': [532, 954, 1908, 2967, 3083, 3247, 3291, 3420, 3462, 3538, 3630, 3704, 4006, 5148, 5491, 5509, 5788], 'enzymes': [533, 705, 2745, 5789], 'ω-monomethylarginine': [538, 710], 'G-dimethylarginine.': [543], 'include': [547, 586], 'many': [548, 1347, 3383], 'RNA': [549], 'binding': [550, 3432], 'transporting': [552], 'proteins,': [553, 558, 597, 2858, 2883], 'transcription': [554], 'factors,': [555], 'matrix': [557], 'cytokines': [560], '(4.Gary': [561, 608, 761, 1353, 4203, 4443, 5518], 'J.D.': [562, 609, 762, 799, 832, 859, 922, 1073, 1203, 1290, 1316, 1354, 1458, 2053, 2079, 2110, 2211, 2258, 2475, 2652, 3118, 3144, 3187, 4204, 4444, 4767, 4793, 4847, 4873, 5351, 5519, 5560, 5586, 5665], 'Clarke': [563, 610, 763, 800, 835, 860, 929, 1076, 1206, 1293, 1317, 1355, 1459, 1553, 1888, 2056, 2080, 2111, 2212, 2259, 2476, 2655, 3121, 3145, 3188, 4205, 4445, 4770, 4794, 4850, 4874, 5354, 5520, 5563, 5587, 5666, 5889], 'Prog.': [565, 612, 765, 1357, 4207, 4447, 5522], 'Nucleic': [566, 613, 766, 1358, 4208, 4448, 5523], 'Acids': [567, 614, 767, 1359, 4209, 4449, 5524], 'Mol.': [569, 616, 670, 769, 1361, 4211, 4451, 4516, 4569, 4974, 5526], '1998;': [571, 618, 695, 771, 805, 867, 995, 1036, 1324, 1363, 1424, 1466, 1594, 2087, 2118, 2219, 2266, 2311, 2483, 2802, 3152, 3195, 3266, 4112, 4213, 4453, 4644, 4801, 4881, 4939, 5054, 5128, 5445, 5528, 5594, 5673], '61:': [572, 619, 772, 1364, 4214, 4454, 5529], '65-131Crossref': [573, 620, 773, 1365, 4215, 4455, 5530], 'Functions': [577], 'may': [585, 1629, 4626], 'regulation': [587, 598, 5795, 5822], 'transcription,': [589], 'modulation': [590], 'affinity': [593, 2014, 2427, 2839], 'nucleic': [595], 'acid-binding': [596], 'interferon': [600, 1231], 'signaling': [601], 'pathways,': [602], 'targeting': [604], '5.Abramovich': [624], 'C.': [625, 1120, 1152, 1158, 1160, 1176, 1235, 1418, 1675, 1690, 1720, 1778, 1826, 1858, 2028, 2148, 2327, 2412, 5379], 'Yakobson': [626, 1236], 'B.': [627, 1164, 1237, 1750, 1796, 2001, 4266, 4420, 5409, 5898], 'Chebath': [628, 648, 1238, 1258], 'Revel': [630, 650, 1240, 1260], 'M.': [631, 651, 1124, 1128, 1174, 1241, 1261, 1380, 3219, 5697], 'EMBO': [632, 1135, 1242], '1997;': [634, 1244, 1832, 1864, 2154, 2351], '260-266Crossref': [636, 1246], '(155)': [639, 1249], '6.Altschuler': [642, 1252], 'L.': [643, 1126, 1253], 'Wook': [644, 1254], 'J.O.': [645, 1255], 'Gurari': [646, 1256], 'D.': [647, 887, 1130, 1257, 1503, 1792, 1798, 5608, 5748], 'Interferon': [653, 1263], 'Cytokine': [654, 1264], '1999;': [656, 903, 1266, 1388, 1519, 3227, 5624, 5705, 5764], '19:': [657, 1267], '189-195Crossref': [658, 1268], '(40)': [661, 1271], '7.Pintucci': [664], 'G.': [665, 1122, 4515, 4568, 4973], 'Quarto': [666], 'N.': [667, 1148, 4495, 4953, 5067], 'Rifkin': [668], 'D.B.': [669], 'Cell.': [672, 4517, 4570, 4975], '1996;': [673, 842, 934, 1083, 1181, 1213, 1300, 2063, 2662, 3128, 4777, 4857, 5361, 5570], '7:': [674], '1249-1258Crossref': [675], '(61)': [678], '8.Shen': [681], 'E.C.': [682, 982, 1023], 'Henry': [683, 983, 1024, 1421], 'M.F.': [684, 984, 1025, 1422], 'Weiss': [685, 985, 1026], 'V.H.': [686, 986, 1027], 'Valentini': [687, 987, 1028], 'S.R.': [688, 988, 1029], 'Silver': [689, 989, 1030, 1419], 'P.A.': [690, 990, 1031, 1420], 'Lee': [691, 991, 1032], 'M.S.': [692, 992, 1033], 'Genes': [693, 993, 1034], 'Dev.': [694, 994, 1035], '12:': [696, 996, 1037], '679-691Crossref': [697, 997, 1038], '(255)': [700, 1000, 1041], 'II': [704, 757], 'symmetric': [712], 'G,N′G-dimethylarginine': [714], '(9.Ghosh': [715, 4476, 4906, 5021], 'S.K.': [716, 4477, 4907, 5022], '1988;': [724, 739, 1756, 4272, 4485, 4915, 5030, 5415], '263:': [725, 4486, 4916, 5031], '19024-19033Abstract': [726, 4487, 4917, 5032], '10.Young': [733], 'P.R.': [734], 'Waickus': [735], 'C.M.': [736], '250:': [740], '221-226Crossref': [741], '(9)': [744], 'Myelin': [747], 'basic': [748], 'only': [752, 951, 2436, 3452, 3804, 3880, 4014, 4044, 4344, 5774], 'known': [753, 5541], 'substrate': [754, 1007, 2187, 2426, 2838, 2907, 3183, 3493, 5203, 5555, 5849], 'III': [779], 'enzyme,': [780], 'yeast,': [783, 957], 'catalyzes': [784, 1643], 'monomethylation': [786], 'internal': [789], 'δ-guanidino': [790], 'nitrogen': [791], 'atom': [792], '(11.Zobel-Thropp': [796], 'P.': [797, 1162, 1166], 'Gary': [798, 831, 858, 1072, 1202, 1289, 1315, 1457, 2052, 2078, 2109, 2210, 2257, 2474, 2651, 3117, 3143, 3186, 4766, 4792, 4846, 4872, 5350, 5559, 5585, 5664], '273:': [806, 868, 1325, 1467, 1595, 2088, 2119, 2220, 2267, 2312, 2484, 2803, 3153, 3196, 3267, 4113, 4645, 4802, 4882, 4940, 5055, 5129, 5446, 5595, 5674], '29283-29286Abstract': [807], '(56)': [815, 3617], 'Four': [818], 'enzymatically': [819], 'active': [820, 1482, 2897, 3171], 'arginineN-methyltransferases': [824], 'been': [826, 1438, 4435, 4535, 5016, 5311], 'reported:': [827], '(12.Lin': [829, 1070, 1200, 1287, 2050, 2649, 3115, 4764, 4844, 5348, 5557], 'W.J.': [830, 924, 1071, 1201, 1288, 2051, 2650, 3116, 4765, 4845, 5349, 5558], 'Yang': [833, 925, 1074, 1204, 1291, 2054, 2653, 3119, 4768, 4848, 5352, 5561], 'M.C.': [834, 926, 1075, 1205, 1292, 1734, 2055, 2654, 3120, 4769, 4849, 5353, 5393, 5562], 'Herschman': [837, 862, 927, 1078, 1208, 1295, 1319, 1381, 1461, 2058, 2082, 2113, 2214, 2261, 2478, 2657, 3123, 3147, 3190, 3220, 4772, 4796, 4852, 4876, 5356, 5565, 5589, 5668, 5698, 5887], 'H.R.': [838, 863, 928, 1079, 1209, 1296, 1320, 1382, 1462, 2059, 2083, 2114, 2215, 2262, 2479, 2658, 3124, 3148, 3191, 3221, 4773, 4797, 4853, 4877, 5357, 5566, 5590, 5669, 5699], '271:': [843, 935, 1084, 1214, 1301, 2064, 2663, 3129, 4778, 4858, 5362, 5571], '15034-15044Abstract': [844, 1085, 1215, 1302, 2065, 2664, 3130, 4779, 4859, 5363, 5572], '(402)': [852, 1093, 1223, 1310, 2073, 2672, 3138, 4787, 4867, 5371, 5580], 'Scholar),': [854, 879, 1812, 2422, 3278, 4279, 4984], 'PRMT3': [855, 1442, 2102, 3522, 5634, 5661, 5838], '(13.Tang': [856, 1455, 2107, 2208, 2255, 2472, 3184, 5662], '16935-16945Abstract': [869, 1326, 1468, 2089, 2120, 2221, 2268, 2485, 3154, 3197, 4803, 4883, 5596, 5675], '(277)': [877, 1334, 1476, 2097, 2128, 2229, 2276, 2493, 3162, 3205, 4811, 4891, 5604, 5683], '(CARM1)': [885], '(14.Chen': [886, 1502, 5747], 'Ma': [888, 1504, 5609, 5749], 'H.': [889, 891, 1505, 1507, 1748, 4264, 5407, 5610, 5612, 5750, 5752], 'Hong': [890, 1506, 5611, 5751], 'Koh': [892, 1508, 5613, 5753], 'S.S.': [893, 1509, 5614, 5754], 'Huang': [894, 1510, 5615, 5755], 'S.M.': [895, 1511, 5616, 5756], 'Schurter': [896, 1512, 5617, 5757], 'B.T.': [897, 1513, 5618, 5758], 'Aswad': [898, 1514, 3334, 5619, 5759], 'D.W.': [899, 1515, 3335, 5620, 5760], 'Stallcup': [900, 1516, 5621, 5761], 'M.R.': [901, 1517, 5622, 5762], 'Science.': [902, 1518, 5623, 5763], '284:': [904, 1520, 5625, 5765], '2174-2177Crossref': [905, 1521, 5626, 5766], '(1020)': [908, 1524, 5629, 5769], 'Scholar)': [910, 1336, 1844, 4893, 5422], '(RMT1)': [918], 'yeast': [920, 971, 1532], '(15.Gary': [921], 'Lin': [923], '12585-12594Abstract': [936], '(185)': [944], 'Knockout': [947], 'RMT1,': [949], 'gene': [955, 1065, 1634, 1911], 'has': [958, 1437, 3855, 3899, 3988, 4533, 5014, 5506], 'no': [959, 1434, 3791, 3900], 'obvious': [960], 'phenotype.': [961], 'mutant': [964, 977], 'allele': [965, 978], 'ofRMT1': [966], 'synthetically': [968], 'lethal': [969], 'combination': [973], 'temperature-sensitive': [976], 'NPL3': [980, 1003], '(8.Shen': [981, 1022], 'RMT1': [1006, 1533], 'involved': [1008, 1638], 'import,': [1012], 'pre-RNA': [1013], 'processing,': [1014], 'export': [1016], 'mRNA': [1018], 'nucleus': [1021], 'PRMT1,': [1044, 1274, 1527, 4059], 'first': [1046, 2694, 3305], 'cloned,': [1055], 'interacting': [1061, 1494], 'immediate-early': [1064], 'products': [1066], 'BTG1': [1067, 1096, 1189], 'TIS21': [1069, 1098, 1191], 'are': [1099, 2451, 2507, 2583, 2605, 2621, 2863, 3361, 3676, 4042, 4132, 4165, 4313, 4330, 4412], 'negative': [1100], 'regulators': [1101], 'cell': [1103, 1112, 2379, 2516, 2629, 2647, 2736, 3310, 3367, 3380, 3424, 3509, 3543, 3933, 4692, 4727, 5228], 'growth': [1104, 1113], 'whose': [1105, 1448], 'overexpression': [1106], 'lead': [1110], 'arrest': [1114], '(16.Rouault': [1115], 'J.P.': [1116, 1134, 1146, 1172], 'Rimokh': [1117, 1153], 'R.': [1118, 1154, 1168, 4497, 4955, 5069], 'Tessa': [1119], 'Paranhos': [1121], 'Ffrench': [1123], 'Duret': [1125], 'Garoccio': [1127], 'Germain': [1129], 'Samarut': [1131, 1169, 1175], 'Magaud': [1133, 1171], '1992;': [1137], '11:': [1138], '1663-1670Crossref': [1139], '(274)': [1142], '17.Rouault': [1145], 'Falette': [1147], 'Guehenneux': [1149], 'F.': [1150], 'Guillot': [1151], 'Wang': [1155], 'Q.': [1156, 4513, 4566, 4971], 'Berthet': [1157], 'Moyret-Lalle': [1159], 'Savatier': [1161], 'Pain': [1163], 'Shaw': [1165], 'Berger': [1167], 'Ozturk': [1173], 'Puisieux': [1177], 'A.': [1178, 1374, 1378, 3213, 3217, 3611, 5691, 5695], 'Nat.': [1179], 'Genet.': [1180], '14:': [1182], '482-486Crossref': [1183], '(359)': [1186], 'interact': [1192, 5252], 'regulate': [1196], 'its': [1197, 1406, 3852, 5010], 'enzymatic': [1198], 'also': [1227, 3905, 4073, 5015, 5895], 'associates': [1228], 'α/β': [1232], 'receptor': [1233], '(5.Abramovich': [1234], 'predominantly': [1276], 'protein,': [1278, 2951], 'exists': [1279, 1707], 'large': [1282, 4471, 5256, 5341], '300–400': [1285, 4474, 4762, 5346], 'kDa': [1286, 2889, 4475, 4564, 4763, 5347], '13.Tang': [1313, 2076, 3141, 4790, 4870, 5583], 'methylates': [1338], 'RGG': [1342], 'RXR': [1344], 'motifs': [1345], 'RNA-binding': [1348], 'other': [1351, 3920], '18.Smith': [1369, 3208, 5686], 'J.J.': [1370, 3209, 5687], 'Rucknagel': [1371, 3210, 5688], 'K.P.': [1372, 3211, 5689], 'Schierhorn': [1373, 3212, 5690], 'Tang': [1375, 3214, 5692], 'Nemeth': [1377, 3216, 5694], 'Linder': [1379, 3218, 5696], 'Wahle': [1383, 3222, 5700], 'E.': [1384, 1794, 3223, 5701], '274:': [1389, 3228, 5706], '13229-13234Abstract': [1390, 3229, 5707], '(136)': [1398, 3237, 5715], 'PRMT2': [1401], 'because': [1404], 'sequence': [1407, 1769], 'similarity': [1408], '(19.Scott': [1411], 'H.S.': [1412], 'Antonarakis': [1413], 'S.E.': [1414], 'Lalioti': [1415], 'M.D.': [1416], 'Rossier': [1417], 'Genomics.': [1423], '48:': [1425], '330-340Crossref': [1426], '(144)': [1429], 'To': [1432, 1901, 2815, 2934, 3024, 3620, 3752], 'date': [1433], 'demonstrated': [1439, 4544], 'PRMT2.': [1441], 'monomeric': [1445], 'cytoplasmic': [1446], 'overlaps': [1450], 'CARM1,': [1479, 1530], 'third': [1481], 'discovered,': [1488], 'cloned': [1490], 'carboxyl-terminal': [1497, 1847], 'region': [1498], 'p160': [1500], 'coactivator': [1501], 'PRMT2,': [1528], 'PRMT3,': [1529, 5548], 'all': [1534, 3417], 'contain': [1535, 1881, 3579, 3790, 3848, 5165, 5773, 5784], 'signature': [1536, 1884], 'regions': [1537], '(I,': [1538], 'post-I,': [1539], '-II,': [1540], '-III)': [1542], 'constitute': [1544], 'core': [1546], 'AdoMet-binding': [1549], 'site': [1550], '(20.Kagan': [1551, 1886], 'R.M.': [1552, 1887], 'Arch.': [1555, 1691, 1890], '1994;': [1558, 1804, 1893, 3612, 4504, 4962, 5076], '310:': [1559, 1894], '417-427Crossref': [1560, 1895], '(429)': [1563, 1898], 'recent': [1568, 4592], 'arginineN-methyltransferase': [1573, 1922, 3949, 4708, 4828, 4904, 4997, 5110, 5172, 5309, 5333, 5472], '(21.Kim': [1579, 2296, 2787, 3251, 4629, 5113, 5430], 'Park': [1581, 2298, 2789, 3253, 4099, 4631, 4926, 5041, 5115, 5432], 'G.H.': [1582, 2299, 2790, 3254, 4100, 4632, 4927, 5042, 5116, 5433], 'Joo': [1583, 2300, 2791, 3255, 4101, 4633, 4928, 5043, 5117, 5434], 'W.A.': [1584, 2301, 2792, 3256, 4102, 4634, 4929, 5044, 5118, 5435], 'Cook': [1587, 1827, 1859, 2149, 2304, 2346, 2795, 3259, 3599, 4105, 4637, 4932, 5047, 5121, 5438], 'R.J.': [1588, 1671, 1688, 1716, 1774, 1828, 1860, 2026, 2150, 2305, 2325, 2348, 2410, 2796, 3260, 3600, 4106, 4638, 4933, 5048, 5122, 5375, 5439], 'Williams': [1589, 2306, 2797, 3261, 4107, 4639, 4934, 5049, 5123, 5440], 'K.R.': [1590, 2307, 2798, 3262, 4108, 4640, 4935, 5050, 5124, 5441], '27374-27382Abstract': [1596, 2313, 2804, 3268, 4114, 4646, 4941, 5056, 5130, 5447], '(5)': [1604, 2321, 2356, 2812, 3276, 4122, 4654, 4949, 5064, 5138, 5455], 'Sequence': [1607], 'analysis': [1608, 2465, 3801], 'polypeptide': [1612, 2849, 2885, 4528, 4607], 'preparation': [1615, 2434, 2827, 2845, 2895, 2922, 2945, 3017, 3048, 3091], '(FDH,': [1619], 'EC': [1620], '1.5.1.6),': [1621], 'suggesting': [1622, 4622], 'encoded': [1631], 'encoding': [1635], 'folate': [1640], 'metabolism.': [1641], '(i)': [1644, 1942, 4815, 5147], 'NADP+-dependent': [1645, 1666], 'oxidation': [1646, 1667], '(10-FTHF)': [1649], 'tetrahydrofolate,': [1651], 'NADPH,': [1652], 'CO2;': [1654], '(ii)': [1655, 1954, 4835, 5159], 'NADP+-independent': [1656], 'hydrolysis': [1657], '10-FTHF': [1659], 'formate': [1661], 'tetrahydrofolate;': [1663], '(iii)': [1665, 5193], '2-propanal': [1669], '(22.Cook': [1670, 1715, 1773], 'Lloyd': [1672, 1717, 1775, 5376], 'R.S.': [1673, 1718, 1776, 5377], 'Wagner': [1674, 1689, 1719, 1777, 1825, 1857, 2027, 2147, 2326, 2411, 5378], '1991;': [1679, 1724, 1782, 5383], '266:': [1680, 1725, 1783, 5384], '4965-4973Abstract': [1681, 1726, 1784, 5385], 'Scholar,23.Cook': [1687], '1995;': [1694, 4519, 4572, 4977], '321:': [1695], '336-344Crossref': [1696], '(13)': [1699], 'tetramer': [1710], 'identical': [1712], '99-kDa': [1713], 'subunits': [1714], '24.Scrutton': [1733, 5392], 'Beis': [1735, 5394], 'I.': [1736, 5395], '1979;': [1739, 5398], '177:': [1740, 5399], '833-846Crossref': [1741, 5400], '(29)': [1744, 5403], '25.Min': [1747, 5406], 'Shane': [1749, 4265, 5408], 'Stokstad': [1751, 4267, 5410], 'E.L.': [1752, 4268, 5411], 'Biochim.': [1753, 4269, 5412], 'Acta.': [1755, 4271, 5414], '967:': [1757, 4273, 5416], '348-353Crossref': [1758, 4274, 5417], '(52)': [1761, 4277, 5420], 'cDNA-deduced': [1765], 'amino': [1767], 'acid': [1768], 'contains': [1770, 2435, 2846, 4759, 5007], 'several': [1771], 'domains': [1772], '26.Schirch': [1791], 'Villar': [1793], 'Maras': [1795], 'Barra': [1797], 'Schirch': [1799], 'V.': [1800], '269:': [1805], '24728-24735Abstract': [1806], 'including': [1813], 'amino-terminal': [1815], 'phosphoribosyl-glycinamide': [1816], 'formyltransferase': [1817], 'homologous': [1818, 1850], '(amino': [1820, 1852], 'acids': [1821, 1853], '1–203)': [1822], '(27.Krupenko': [1823, 2145], 'S.A.': [1824, 1856, 2146], '272:': [1833, 1865, 2155], '10273-10278Abstract': [1834, 2156], '(31)': [1842, 2164], 'aldehyde': [1848], '417–902)': [1854], '(28.Krupenko': [1855], '10266-10272Abstract': [1866], '(47)': [1874], 'any': [1882, 3626, 5303], 'sequences': [1885], 'understand': [1902], 'further': [1903, 2542, 2830, 3824, 4170, 5152], 'relationship': [1905], 'between': [1906, 5300, 5329, 5808], 'products,': [1912], 'we': [1913, 2832, 2952, 3037, 3103, 3175, 3279, 3632, 4662, 4985, 5497], 'sought': [1914], 'identify': [1916], 'used': [1928, 2575, 2733, 2953, 3038, 3500, 4248, 4407, 5731], 'cultured': [1929, 2584, 3111], 'tissues': [1933, 2676, 3921, 4833], 'determine': [1941, 2935, 4255], 'which': [1943, 3284, 3317, 5006], 'whether': [1955, 2817, 2936, 3622, 3907, 4256], 'preparations': [1964, 4406], 'catalyzed': [1966], 'copurified,': [1974], 'distinct,': [1976, 5554], 'methyltransferase.': [1977], 'S-Adenosyl-l-[methyl-3H]-l-methionine': [1978], '(specific': [1979], 'about': [1981], '75': [1982], 'Ci/mmol)': [1983], 'obtained': [1985, 1997], 'NEN': [1987], 'Life': [1988], 'Science': [1989], 'Products': [1990], 'Amersham': [1992], 'Pharmacia': [1993], 'Biotech.': [1994], '10-Formyl-5,8-dideazafolate': [1995], 'Dr.': [1999], 'John': [2000], 'Hynes,': [2002], 'Department': [2003], 'Pharmaceutical': [2005], 'Chemistry,': [2006], 'Medical': [2007], 'University': [2008, 5901], 'South': [2010], 'Carolina.': [2011], '5-Formyltetrahydrofolate': [2012], '(FTHF)': [2013], 'prepared': [2017, 2833, 3936], 'covalently': [2019], 'linking': [2020], '5-FTHF': [2021], 'AH-Sepharose': [2023], '4B': [2024, 2525], '(29.Cook': [2025, 2409], 'Methods': [2029, 2328, 2349, 2413], 'Enzymol.': [2030, 2329, 2350, 2414], '1986;': [2031, 2330, 2415], '122:': [2032, 2331, 2416, 2768], '251-255Crossref': [2033, 2332, 2417], '(14)': [2036, 2335, 2420], 'GST-PRMT1,': [2040], 'GST-GAR,': [2041, 2194, 4685, 4717, 5637], 'hnRNP': [2043, 2195, 3914, 3957, 3984, 4067, 4686, 4718, 5178, 5280, 5306, 5638, 5640], 'A1': [2044, 3915, 3958, 5179], 'were': [2045, 2104, 2193, 2234, 2248, 2288, 2459, 2518, 2536, 2541, 2574, 2677, 3280, 3781, 3935, 3951, 4291, 4559, 5730], 'described': [2048, 2105, 2253, 2291, 2343, 2407, 2470, 2508, 2751, 4093], 'previously': [2049, 2106, 2254, 2344, 2408, 2471, 2752, 2777, 3596], 'antibodies': [2103, 2506, 2521, 3354, 3733], 'Anti-FDH': [2131, 3053, 4701], 'generated': [2134, 3306, 3633], 'rabbits': [2136], 'using': [2137, 2902, 3178, 3829, 3953, 4087, 4714], 'antigen': [2144, 4037], 'Methyltransferase': [2167], 'assayed': [2170, 3782], 'at': [2171, 2392, 2398, 2443, 2526, 2696, 2703, 2719, 2726, 4545, 4560], '37': [2172], '°C': [2173, 2528, 2705], 'times': [2175, 2559], 'final': [2178, 2431], 'volumes': [2179], 'specified': [2181], 'figure': [2183, 2512], 'legends.': [2184, 2513], '[3H]AdoMet.': [2189], 'A1,': [2196, 4687, 4719, 5639], 'lysates': [2202, 2517, 3636, 3653, 3670, 3688, 3771, 3934, 3969], 'Methylation': [2232], 'reactions': [2233], 'stopped': [2235], 'adding': [2237], 'SDS-PAGE': [2238, 2441, 2462, 2866, 4316, 4551], 'sample': [2239], 'buffer': [2240], 'resolved': [2242], 'on': [2243, 2284, 2440, 2448, 2570, 2865, 4550], 'SDS-PAGE.': [2244], 'methylated': [2246], 'visualized': [2249, 2452], 'fluorography,': [2251], 'A': [2279, 3397], 'separate': [2280], 'set': [2281], 'assays': [2283, 5537], 'performed': [2289, 2749], 'et': [2294, 2755, 4096], 'al.': [2295, 2756], '29.Cook': [2324], 'determined': [2341], '(30.Cook': [2347], '281:': [2352], '129-134Crossref': [2353], '1.0-ml': [2360], 'reaction': [2361, 3780], 'mixture': [2362], 'contained': [2363], '100': [2364, 2370, 2375, 4561], 'mm': [2365], 'HEPES': [2366], 'pH': [2367], '7.8': [2368], 'buffer,': [2369], 'μm': [2371, 2376, 2599, 4376, 4385, 4393], '2-mercaptoethanol,': [2372], '61.6': [2373], 'μm10-formyl-5,8-dideazafolate,': [2374], 'NADP+,': [2377], 'extract.': [2380], 'production': [2382], '5,8-dideazafolate': [2384], 'monitored': [2386], 'increase': [2389], 'absorbance': [2391], '295': [2393], 'nm': [2394], '15': [2396], 'min': [2397, 2546, 2635, 2702, 2725], '23': [2399], '°C.': [2400, 2728], 'Rat': [2401], 'purified,': [2405, 4603], 'through': [2423, 2836], '5-FTHF-Sepharose': [2425], 'column': [2428], 'step.': [2429, 2841], 'band': [2439, 2886], '110': [2444, 2851, 4616], 'kDa,': [2445, 4617], 'when': [2446, 2867], 'Coomassie': [2454, 2873, 4415], 'Blue': [2455, 2874, 4416], 'staining.': [2456], 'Protein': [2457, 3948, 4190], 'samples': [2458], 'subjected': [2460, 2632, 2716, 4314], 'immunoblotting': [2464], 'silver': [2467], 'staining': [2468, 4417], 'Specific': [2496], 'conditions': [2497, 4342], 'immunoprecipitation': [2499, 3699, 3779], 'anti-PRMT1,': [2501, 3809], 'anti-PRMT3,': [2502, 3449, 3810], 'anti-FDH,': [2503, 3805], 'control': [2505, 2962, 2985, 3395, 3466, 3484, 3529, 3732, 3812, 4026], 'relevant': [2511], 'general,': [2515], 'incubated': [2519, 4292], 'A-Sepharose': [2524, 2572, 3407, 3435], '4': [2527, 2704, 2727], '90–120': [2530], 'min.': [2531, 4300], 'Supernatant': [2532], 'pellet': [2534, 2539], 'fractions': [2535, 2540], 'recovered.': [2537], 'washed': [2543, 2606], '10': [2545, 2701, 4375, 4384, 4392], 'PBS': [2548, 2563, 2609, 2613], 'containing': [2549, 2683], '0.5%': [2550, 2554], 'Triton': [2551], 'X-100': [2552], 'Tween': [2555], '20': [2556, 2598, 4299], '3': [2558, 2990, 3713, 5181], 'then': [2561, 3573], 'detergents.': [2566], 'precipitated': [2568], 'beads': [2573], 'directly': [2576], 'vitromethyltransferase': [2579, 2900], 'assays.': [2580], "Dulbecco's": [2586], 'modified': [2587], "Eagle's": [2588], 'medium,': [2589], '10%': [2590], 'fetal': [2591], 'bovine': [2592], 'serum': [2593], 'presence': [2596], 'Adox': [2600], '48': [2602], 'h.': [2603], 'Cells': [2604, 2620], 'twice': [2607], 'harvested': [2611], 'protease': [2615, 2684], 'inhibitors': [2616], '(Roche': [2617, 2687], 'Molecular': [2618, 2688], 'Biochemicals).': [2619, 2689], 'lysed': [2622], 'brief': [2624], 'low': [2625], 'power': [2626], 'sonication,': [2627], 'lysate': [2630, 2648, 2737, 3311, 3368, 3381, 4693], '5': [2634, 2981], 'centrifugation.': [2637], 'supernatant': [2639, 2711, 2730, 3710, 3775], 'fraction': [2640, 2712, 2731, 3711, 3776, 4543], 'collected': [2642], 'Adox-treated': [2645], 'Mouse': [2675], 'homogenized': [2678], '(PBS)': [2682], 'inhibitor': [2685, 3327], 'mix': [2686], 'crude': [2691], 'extract': [2692], 'centrifuged': [2695], '3,000': [2697], '×': [2698, 2721], 'g': [2699, 2722], 'debris.': [2709], 'recovered': [2714], 'centrifugation': [2718], '100,000': [2720], 'mouse': [2739, 3593, 3634, 3651, 3749, 3758, 3769, 3821, 3845, 3877], 'Photoaffinity': [2741], 'labeling': [2742], 'Hurst': [2754], '(31.Hurst': [2757], 'J.H.': [2758], 'Billingsley': [2759], 'M.L.': [2760], 'Lovenberg': [2761], 'W.': [2762], '1984;': [2767], '499-508Crossref': [2769], '(32)': [2772], 'test': [2816, 3621], 'fractionated,': [2831], 'chromatography': [2840], 'kDa.': [2852], 'With': [2853], 'extensive': [2854, 4436], 'overloading': [2855], 'some': [2859, 3419, 5507], 'minor': [2860, 2881], 'contaminating': [2861, 2882], 'visible': [2864], 'stained': [2871], 'dye': [2875], '(data': [2876, 3795], 'shown).': [2878, 3797], 'Among': [2879], 'these': [2880, 3650, 4053, 4172, 4409, 5653, 5809], '45': [2888, 4563], 'detected.': [2891], 'This': [2892, 3426, 5000, 5828], 'assays,': [2901], 'GST-GAR': [2903, 3179, 3666, 3955, 3982, 5176], '(Fig.': [2908, 3049, 3928, 3962, 4033, 4038, 5157, 5214, 5295], '1,': [2909, 3050, 5318], 'panel': [2910, 3051, 3370, 3390, 3655, 4040, 4304, 4419], 'A,': [2911, 2979, 2988, 3019, 3656, 4305, 4347, 4354], 'lane': [2912, 3392], '7).': [2913], 'specific': [2916, 2929, 5648], 'less': [2924, 3581], 'than': [2925, 3464, 3586, 3995, 5658], '1%': [2926], 'GST-PRMT1.': [2933], 'intrinsically': [2947], 'associated': [2948], 'antisera': [2954, 3447], 'against': [2955, 3665, 3980, 5174], 'well': [2960, 3403, 4536], 'antiserum,': [2963], 'immunoprecipitate': [2965, 3035, 3067, 3077, 3471, 3498, 4705], 'preparation.': [2974, 3002], 'Neither': [2975], '(panel': [2978, 2987, 3018, 3680, 3783, 3833, 4008, 4346, 4353], 'lanes': [2980, 2989, 3020, 3657, 4348, 4355], 'and6)': [2982], 'nor': [2983], 'and4)': [2991], 'precipitate': [2993, 3741], 'significant': [2994, 3627, 4737], 'precipitates': [3007], 'most': [3008, 3170, 3297, 4556, 4667, 4822], 'GST-GAR-methylating': [3011, 3683, 3742, 3874, 3902, 3917], '2).': [3023], 'confirm': [3025, 3753], 'ability': [3027, 4323], 'bind': [3033, 4241, 4281, 4325], 'immunodeplete': [3042], 'B).': [3052, 3681], 'immunodepletes': [3055], '90%': [3056], 'activity.': [3060, 3069, 3098, 3303, 3816, 3903, 5510], 'specifically': [3076], 'activities;': [3081], 'separated': [3094, 5288], 'our': [3100, 5261, 5863], 'studies': [3102, 4461], 'PRMTs': [3106], '(PRMT1': [3107], 'PRMT3)': [3109], 'fibroblast': [3113], 'far': [3168], 'tested,': [3177], 'Because': [3240, 4814], 'reported': [3243], 'interested': [3281], 'determining': [3283], 'total': [3300, 4741], 'treating': [3313], 'Adox,': [3316], 'inhibits': [3318], 'metabolizesS-adenosylhomocysteine,': [3322], 'potent': [3324], '(32.Najbauer': [3328], 'Johnson': [3330], 'B.A.': [3331], 'Young': [3332], 'A.L.': [3333], '1993;': [3339, 4225], '268:': [3340], '10501-10509Abstract': [3341], 'Western': [3348, 3827], 'blotting': [3349], 'indicates': [3355], 'both': [3357, 3954, 3981, 4676, 5175, 5635], '(Fig.2,': [3369, 3389], 'A).': [3371, 3964, 4009], 'methylate': [3382, 3489, 5636], 'after': [3385], '[3H]AdoMet': [3386, 4294, 4312, 4333, 4368], 'added': [3388], 'B,': [3391], '1).': [3393], 'antibody-protein': [3396], 'Sepharose': [3398], '(lane': [3400, 3411, 3415, 3454, 3472, 3478, 3481, 3485, 3518, 3523, 3526, 3530, 4378, 4387, 4395], '5)': [3401], 'anti-PRMT3': [3410, 3477, 3718], '3)': [3412], '4)': [3416, 5183], 'deplete': [3418, 3457], 'lysate.': [3425], 'presumably': [3428], 'due': [3429], 'nonspecific': [3431], 'and/or': [3439, 4258], 'substrates.': [3442], 'three': [3446, 5540], '(anti-PRMT1,': [3448], 'anti-FDH),': [3451], '2)': [3455], 'greater': [3459, 5657], 'degree': [3460], 'serum.': [3467], 'Only': [3468], '6),': [3473], '7),': [3479], '8),': [3482], '9)': [3486], 'immunoprecipitates,': [3487], 'GST-GAR.': [3494], 'When': [3495, 3660, 5727], 'reconstitute': [3502], 'lysate,': [3510], 'pattern': [3515], 'restored': [3517], '10).': [3519], '11),': [3524], '12),': [3527], '13)': [3531], 'immunoprecipitates': [3532, 3814], 'cannot': [3533, 5498], 'restore': [3534], 'hypomethylated,': [3541], 'PRMT1-immunodepleted': [3542], 'lysates.': [3544, 3751, 4728], 'These': [3545, 4010, 5458], 'results': [3546, 3836, 4051, 5262], 'suggest': [3547], 'If': [3563, 5216], 'liver,': [3572, 3853], 'livers': [3574, 3587, 3759, 3822], 'should': [3578, 4240], 'much': [3580, 5656], 'FDH(+/−)': [3589, 3638, 3672, 3746, 3871, 4046], 'mice.': [3590, 3947, 4049], 'characterized': [3595], '(33.Champion': [3597], 'K.M.': [3598], 'Tollaksen': [3601], 'S.L.': [3602], 'Giometti': [3603], 'C.S.': [3604], 'Proc.': [3605], 'Natl.': [3606], 'Acad.': [3607], 'Sci.': [3608], 'U.': [3609], '91:': [3613], '11338-11342Crossref': [3614], 'deficiency': [3628], 'activity,': [3631, 4675, 5005, 5191], 'compared': [3643, 4074], '(Fig.3,': [3654], 'and10).': [3659], 'quantitated,': [3661], 'significantly': [3678, 5221], 'different': [3679, 5840], 'immunoprecipitated': [3691, 3882, 3897, 4016], '(lanes': [3695, 3712, 3719, 3726, 3734], '7': [3696], 'and16).': [3697], 'After': [3698], 'antibody,': [3702, 3894], 'little': [3703], 'left': [3707], '12).': [3715], '4,': [3720, 4039], '8,': [3721], '13,': [3722], '17),': [3724], '5,': [3727, 4303], '9,': [3728], '14,': [3729], 'and18),': [3730], '2,': [3735, 4696, 5320], '6,': [3736], '11,': [3737], 'and15)': [3738], 'do': [3739], 'genotype': [3755, 3818], 'specificity,': [3764], 'C).': [3784], 'Liver': [3785], 'detectable': [3792, 3901, 4043, 4706], 'confirmed': [3802, 3825], 'antibodies,': [3813], 'blot': [3828], 'D).': [3834], 'presented': [3837], 'Fig.': [3839, 4302], '3suggest': [3840], 'that,': [3841], 'although': [3842], 'it': [3854, 4057, 5232], 'levels': [3860, 5167, 5186], 'those': [3863], 'heterozygote': [3870], 'mouse.': [3872], 'antibodies.': [3885, 4027], 'immunodepleted': [3890], 'analyzed': [3906, 4413], 'bulk': [3911], '4).': [3929, 4396, 4700, 5324], 'experiment,': [3932], 'brains,': [3938], 'livers,': [3939], 'testes': [3941], 'analyzed,': [3952], '4,panel': [3963, 4034], 'Brain,': [3965], 'testis,': [3966, 3998], 'Although': [3986, 4153], 'substantially': [3989, 4004], 'more': [3990, 4005, 4381, 4591], 'brain': [3996], 'latter': [4000], 'organs': [4002], 'B)': [4035], 'C)': [4041], 'FDH(+/+)': [4048, 4085, 4150], 'experiments': [4054, 4411, 4817, 5315], 'indicate': [4055, 5088, 5263, 5538], 'correlates': [4063], 'GST-GAR-': [4065, 5278, 5304], 'A1-methylating': [4068, 5281, 5307], 'hepatic': [4076, 4185], 'FDH(−/−),': [4082, 4147], 'mice,': [4086], '“protein': [4089], 'methylase': [4090, 5019, 5189], 'I”': [4091], 'assay': [4092], 'al.(21.Kim': [4097], 'values,': [4126], 'pmol/min/mg': [4128], '±': [4130, 4134, 4137, 4141], 'S.D.,': [4131], '4.50': [4133], '0.28,': [4135], '3.19': [4136], '0.50,': [4138], '2.80': [4140], '0.28': [4142], 'animals,': [4151], 'reasons': [4155], 'increased': [4157], 'clear': [4167], 'bear': [4169], 'investigation,': [4171], 'data': [4173], 'clearly': [4174], 'demonstrate': [4175, 4663, 4818], 'provide': [4180], 'contribution': [4183], 'activities.': [4189], 'N-methyltransferases': [4192], 'AdoMet': [4197, 4329, 4377], '34.Clarke': [4219], 'Curr.': [4221], 'Opin.': [4222], 'Cell': [4223], '5:': [4226], '977-983Crossref': [4227], '(201)': [4230], 'would': [4234], 'expect': [4235], 'perhaps': [4243], 'cross-link': [4244, 4283, 4327, 5198], 'AdoMet.': [4246, 4285, 4361], 'UV': [4250, 4296], 'irradiation': [4251], 'cross-linking': [4252, 4364, 4410], 'method': [4253], 'GST-PRMT1': [4257, 4290, 4308, 4405, 5212], 'NADP+-binding': [4261], '(25.Min': [4263], 'Affinity-purified': [4286], 'recombinant': [4289, 5211, 5478], 'fluorography.': [4318], 'Proteins': [4319], 'labeled': [4331], 'give': [4335], 'bands': [4336, 4549, 4558], 'fluorograph.': [4339], 'Under': [4340], 'used,': [4343], '1–4),': [4349], '5–8),': [4356], 'Binding': [4362], 'competed': [4371], 'away': [4372, 5289], 'unlabeled': [4374], '2),': [4379], 'completely': [4382, 5287], 'AdoHcy': [4386], '3),': [4388], 'NADP+': [4394], 'amount': [4398], 'purity': [4400], 'Since': [4421], 'ago,': [4432], 'there': [4433], 'efforts': [4437], 'characterize': [4439], 'responsible': [4442], 'Previous': [4459], 'purification': [4460, 5111], 'shown': [4463], 'native': [4467, 4751, 4837, 5342], '35.Rawal': [4494, 4952], 'Rajpurohit': [4496, 4954, 5068], 'Biochem': [4502, 4960, 5074], '300:': [4505, 4963, 5077], '483-489Crossref': [4506, 4964, 5078], '(44)': [4509, 4967, 5081], '36.Liu': [4512, 4970], 'Dreyfuss': [4514, 4567, 4972], '15:': [4520, 4573, 4978], '2800-2808Crossref': [4521, 4574, 4979], '(272)': [4524, 4577, 4982], 'composition': [4529], 'characterized.': [4537], 'one': [4539, 5775], 'purest': [4542], '8': [4547], 'analysis.': [4552], 'Two': [4553], 'prominent': [4557], '(36.Liu': [4565], '45-kDa': [4581], 'matches': [4583, 4894], 'PRMT1.': [4588], 'preparation,': [4610], 'bifunctional': [4628], 'current': [4659], 'however,': [4661], 'tissues,': [4683, 4713], '(Figs.': [4694, 5180, 5316], 'Figure': [4695, 4697, 4699, 5317, 5319, 5321, 5323], '3,': [4698, 5322], 'It': [4729, 5814], 'is,': [4730], 'therefore,': [4731], 'unlikely': [4732, 5092], 'portion': [4738], 'mass': [4753, 5344], 'cellular': [4756], '21.Kim': [4924, 5039], 'catalytic': [4991, 5012], 'subunit': [4992], 'subunit,': [5013], 'termed': [5017], 'Scholar,35.Rawal': [5066], 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'association': [5426], '5-formyltetrahydrofolate-Sepharose': [5428], 'gels': [5429], 'characteristics': [5460], 'probably': [5461], 'contributed': [5462], 'misidentification': [5465], 'liver.': [5475], 'until': [5477], 'source': [5485], '(such': [5493], 'Escherichia': [5495], 'coli),': [5496], 'rule': [5499], 'out': [5500], 'remote': [5502], 'possibility': [5503], 'intrinsic': [5508], 'Multiple': [5511], 'vitro': [5535], '(PRMT1,': [5547], 'CARM1)': [5550], 'overlapping,': [5552], 'specificities': [5556], '14.Chen': [5607], 'A2,': [5641], 'poly(A)-binding': [5643], 'II.': [5645], 'CARM1': [5723, 5741], 'overlap': [5724], 'well.': [5726], 'histone': [5728], 'substrates,': [5734], 'prefers': [5736, 5742], 'H4': [5737], 'H2A,': [5739, 5744], 'whereas': [5740, 5781], 'H3,': [5743], 'H2B': [5746], 'Yeasts': [5772], 'multiple': [5785], 'overlapping': [5791, 5848], 'distinct': [5794], 'mechanisms': [5796], 'subcellular': [5798, 5841], 'localization.': [5799], 'physiological': [5801], 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