The genetics of obesity: FTO leads the way

Name: Work Video:
Duration: 3 min 30 s
Katherine A. Fawcett; Inês Barroso
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873, 889, 891, 948, 952, 973, 1020, 1050, 1076, 1137, 1171, 1201, 1239, 1286, 1335, 1366, 1372, 1398, 1419, 1431, 1451, 1542, 1546, 1602, 1664, 1668, 1713, 1769, 1786, 1813, 1862, 1890, 1938, 1950, 1970, 2090, 2140, 2150, 2162, 2238, 2264, 2274, 2289, 2306, 2386, 2405, 2503, 2520, 2547, 2596, 2624, 2672, 2684, 2704, 2824, 2874, 2884, 2896, 2972, 2998, 3008, 3023, 3040, 3120, 3139, 3213, 3308, 3416, 3464, 3468, 3489, 3598, 3605, 3620, 3649, 3673, 3697, 3704, 3792, 3794, 3799, 3862, 3876, 3893, 3980, 3984, 4005, 4044, 4069, 4123, 4144, 4176, 4209, 4245, 4279, 4314], 'obesity-associated': [14, 127, 162, 275, 583, 1016, 4091, 4184, 4254], '(FTO)': [15, 163, 585, 1243], 'gene': [16, 47, 164, 195, 584, 609, 657, 763, 787, 862, 917, 941, 1018, 1100, 1130, 1163, 1242, 1261, 1285, 1312, 1326, 1425, 1478, 1535, 1607, 1628, 1657, 1837, 1883, 1914, 1944, 2060, 2083, 2121, 2156, 2356, 2571, 2617, 2648, 2678, 2794, 2817, 2855, 2890, 3090, 3288, 3433, 3457, 3511, 3532, 3718, 3845, 3931, 3949, 3973, 4093, 4147, 4186, 4212, 4256, 4282], 'region': [17, 165, 610, 746, 1738, 1812, 2330, 2432, 2472, 2546, 3064, 3166, 3840], 'with': [18, 39, 166, 187, 311, 334, 593, 667, 728, 766, 790, 851, 865, 920, 944, 1046, 1131, 1197, 1264, 1313, 1402, 1427, 1449, 1481, 1505, 1538, 1660, 1689, 1840, 1884, 1917, 1946, 1968, 2043, 2063, 2084, 2112, 2124, 2158, 2178, 2185, 2196, 2218, 2286, 2359, 2378, 2403, 2574, 2618, 2651, 2680, 2702, 2777, 2797, 2818, 2846, 2858, 2892, 2912, 2919, 2930, 2952, 3020, 3093, 3112, 3137, 3209, 3343, 3363, 3436, 3460, 3851, 3934, 3952, 3976, 4173], 'body': [19, 145, 167, 293, 301, 490, 595, 791, 866, 945, 1001, 1166, 1332, 1428, 1539, 1661, 1947, 2159, 2681, 2893, 3230, 3364, 3372, 3461, 3977], 'index': [21, 169, 793, 868, 947, 1430, 1541, 1663, 1949, 2161, 2683, 2895, 3366, 3463, 3979], '(BMI)': [22, 170, 304], 'risk': [24, 172, 316, 543, 670, 748, 893, 1051, 1511, 3214, 3235, 3315], 'obesity': [26, 174, 356, 545, 672, 972, 1132, 1232, 1240, 1266, 1287, 1373, 1483, 1690, 1861, 1885, 1919, 2044, 2085, 2126, 2305, 2595, 2619, 2653, 2778, 2819, 2860, 3039, 3198, 3311, 3405, 3488, 3759, 3936, 4004, 4058, 4145, 4210, 4280], 'was': [27, 45, 53, 175, 193, 201, 846, 2041, 2775, 3503, 3514, 3762, 3770, 3802, 3826, 3911, 3932], 'identified': [28, 176, 1188, 3283, 3516], 'multiple': [30, 178, 823, 903, 2435, 3169, 4237], 'populations,': [31, 179], 'making': [32, 180], 'FTO': [33, 44, 66, 95, 101, 181, 192, 214, 243, 249, 608, 745, 762, 786, 842, 861, 887, 916, 940, 968, 997, 1017, 1069, 1099, 1129, 1162, 1260, 1284, 1311, 1367, 1424, 1447, 1477, 1499, 1534, 1599, 1656, 1686, 1712, 1789, 1836, 1857, 1882, 1913, 1943, 1966, 2029, 2059, 2082, 2120, 2155, 2301, 2329, 2355, 2383, 2401, 2523, 2570, 2591, 2616, 2647, 2677, 2700, 2763, 2793, 2816, 2854, 2889, 3035, 3063, 3089, 3117, 3135, 3187, 3415, 3432, 3456, 3484, 3510, 3844, 3910, 3948, 3972, 4000, 4033, 4092, 4112, 4141, 4170, 4185, 4206, 4255, 4276, 4304, 4355], 'first': [35, 183, 588, 1579, 3419, 3515], 'locus': [36, 184, 3256], 'unequivocally': [37, 185, 665], 'associated': [38, 186, 310, 333, 591, 666, 726, 765, 789, 864, 919, 943, 1045, 1241, 1263, 1327, 1401, 1480, 1537, 1659, 1688, 1810, 1839, 1916, 2042, 2062, 2123, 2177, 2186, 2195, 2217, 2260, 2325, 2358, 2544, 2573, 2650, 2776, 2796, 2857, 2911, 2920, 2929, 2951, 2994, 3059, 3092, 3208, 3362, 3435, 3459, 3850, 3933, 3951, 3975], 'adiposity.': [40, 188], 'At': [41, 189], 'time,': [43, 191], 'a': [46, 75, 103, 120, 194, 223, 251, 268, 409, 467, 509, 625, 717, 1141, 1206, 1289, 1339, 1567, 1735, 1745, 1793, 1894, 2094, 2249, 2469, 2479, 2527, 2628, 2828, 2983, 3254, 3260, 3286, 3368, 3530, 3555, 3681, 3716, 3818, 3829, 3833, 3839, 3868, 4095, 4150, 4188, 4215, 4243, 4248, 4258, 4285, 4359], 'unknown': [49, 197], 'function': [50, 198, 3507, 3682], 'it': [52, 200, 1743, 1758, 1774, 2477, 2492, 2508, 3394, 3801], 'not': [54, 202, 1559, 1728, 1776, 2214, 2293, 2462, 2510, 2948, 3027, 3803, 3898, 3912], 'known': [55, 203, 1634, 3504, 3804, 3924], 'whether': [56, 204], 'these': [57, 205, 1817, 2181, 2281, 2551, 2915, 3015, 3385, 3765, 3809], 'SNPs': [58, 206, 605, 708, 742, 843, 888, 1500, 1564, 1601, 1684, 1756, 1787, 1807, 2039, 2176, 2187, 2192, 2237, 2261, 2282, 2326, 2381, 2490, 2521, 2541, 2773, 2910, 2921, 2926, 2971, 2995, 3016, 3060, 3115, 3413], 'exerted': [59, 207], 'their': [60, 208, 2003, 2290, 2737, 3024, 4333], 'effect': [61, 209, 994, 1111, 1497, 1693], 'on': [62, 210, 462, 513, 1000, 1112, 1164, 1501, 1514, 1694, 1804, 2272, 2277, 2538, 3006, 3011, 3371, 3559, 3837, 3903, 4236, 4328], 'adiposity': [63, 211, 515], 'by': [64, 212, 403, 848, 3402, 3520, 3534, 3720, 3871, 4324], 'affecting': [65, 213], 'or': [67, 215, 441, 897, 1608, 1815, 2229, 2549, 2963, 3760], 'neighboring': [68, 216], 'genes.': [69, 217, 1613], 'Therefore,': [70, 218], 'this': [71, 133, 219, 281, 644, 2430, 3164, 3929, 4302], 'breakthrough': [72, 220], 'inspired': [74, 222, 4018], 'wealth': [76, 224], 'silico,': [79, 227], 'vitro,': [81, 229], 'vivo': [84, 232], 'analyses': [85, 233, 836, 4029], 'model': [87, 235], 'organisms': [88, 236], 'humans': [90, 238], 'to': [91, 239, 391, 393, 447, 548, 589, 628, 796, 871, 950, 970, 1105, 1331, 1544, 1596, 1643, 1666, 1697, 1702, 1730, 1739, 1747, 1760, 1859, 2023, 2303, 2333, 2440, 2464, 2473, 2481, 2494, 2593, 2757, 3037, 3067, 3174, 3397, 3466, 3486, 3814, 3821, 3878, 3900, 3921, 3982, 4002, 4042, 4051, 4308, 4332], 'improve': [92, 240], 'knowledge': [93, 241, 551], 'function.': [96, 244], 'These': [97, 245, 387, 4231, 4351], 'studies': [98, 246, 617, 654, 675, 683, 701, 2021, 2108, 2755, 2842], 'suggested': [99, 247], 'that': [100, 118, 132, 248, 266, 280, 369, 535, 565, 838, 1683, 2247, 2324, 2429, 2437, 2981, 3058, 3163, 3171, 3341, 3822, 3841, 3928, 4169, 4354, 4365], 'plays': [102, 250], 'role': [104, 252, 1235], 'controlling': [106, 254], 'feeding': [107, 255], 'behavior': [108, 256], 'energy': [110, 258, 556, 1022], 'expenditure.': [111, 259], 'Here,': [112, 260], 'we': [113, 261], 'review': [114, 262, 598], 'approaches': [116, 264], 'taken': [117, 265], 'provide': [119, 267, 634], 'blueprint': [121, 269], 'for': [122, 270, 449, 508, 569, 641, 732, 1228, 1509, 1522, 3257, 3289, 3306, 3563, 3593, 4149, 4214, 4284], 'study': [124, 272, 469, 815, 1227, 1820, 1996, 2212, 2252, 2554, 2730, 2946, 2986, 3263, 3305], 'other': [126, 274, 1612, 2288, 3022, 3796, 3923, 4038], 'genes': [128, 276, 1396, 3553, 3775], 'hope': [131, 279], 'strategy': [134, 282], 'will': [135, 283, 546], 'result': [136, 284], 'increased': [138, 286, 315, 358, 1021], 'understanding': [139, 287], 'biological': [142, 290, 630, 3400], 'mechanisms': [143, 291, 3401], 'underlying': [144, 292, 540], 'weight': [146, 294, 491, 1049, 1172, 3212, 3373], 'regulation.': [147, 295], 'Overweight': [296], 'obesity,': [298, 2441, 3175, 3859, 4117], 'defined': [299], 'as': [300, 422, 1582, 1584, 1635, 3285, 3549, 3768, 3918, 4242, 4247, 4358], 'indices': [303], '>25': [305], '>30,': [307], 'respectively,': [308], 'are': [309, 389, 439, 445, 764, 918, 1044, 1262, 1400, 1687, 1705, 1838, 1915, 2061, 2122, 2357, 2572, 2649, 2795, 2856, 3091, 3207, 3434, 3643, 3950], 'premature': [312], 'death': [313, 3576, 3742], 'through': [314, 1691], 'many': [318, 3195], 'chronic': [319], 'diseases,': [320], 'including': [321], 'type': [322, 733, 817, 1189, 1198, 1369, 1393], '2': [323, 734, 818, 1190, 1199, 1370, 1394, 1586, 2385, 3119], 'diabetes,': [324], 'cardiovascular': [325], 'disease': [326], 'cancer': [328], '[1Kopelman': [329], 'P.': [330], 'Health': [331, 364], 'risks': [332], 'overweight': [335, 354, 379, 396, 440, 896], 'obesity.Obes.': [337], 'Rev.': [338], '2007;': [339, 688, 770, 801, 826, 876, 924, 955, 978, 1246, 1407, 1549, 1671, 1844, 1867, 2067, 2311, 2363, 2578, 2601, 2801, 3045, 3097, 3440, 3471, 3494, 3630, 3956, 3987, 4010, 4100, 4159, 4193, 4224, 4263, 4294], '8:': [340, 4160, 4225, 4295], '13-17Crossref': [341], 'Scopus': [342, 477, 500, 691, 774, 805, 830, 880, 928, 959, 982, 1008, 1033, 1059, 1088, 1118, 1150, 1177, 1216, 1250, 1276, 1301, 1318, 1348, 1381, 1410, 1438, 1469, 1492, 1553, 1675, 1848, 1871, 1903, 1929, 1957, 1988, 2071, 2103, 2136, 2169, 2315, 2367, 2423, 2582, 2605, 2637, 2663, 2691, 2722, 2805, 2837, 2870, 2903, 3049, 3101, 3157, 3222, 3245, 3273, 3296, 3325, 3352, 3380, 3444, 3475, 3498, 3545, 3633, 3658, 3692, 3731, 3960, 3991, 4014, 4083, 4104, 4132, 4162, 4197, 4227, 4267, 4297, 4347], '(502)': [343], 'Google': [344, 479, 502, 530, 693, 776, 807, 832, 882, 930, 961, 984, 1010, 1035, 1061, 1090, 1120, 1152, 1179, 1218, 1252, 1278, 1303, 1320, 1350, 1383, 1412, 1440, 1471, 1494, 1555, 1677, 1850, 1873, 1905, 1931, 1959, 1990, 2073, 2105, 2138, 2171, 2317, 2369, 2425, 2584, 2607, 2639, 2665, 2693, 2724, 2807, 2839, 2872, 2905, 3051, 3103, 3159, 3224, 3247, 3275, 3298, 3327, 3354, 3382, 3446, 3477, 3500, 3547, 3635, 3660, 3694, 3733, 3962, 3993, 4016, 4085, 4106, 4134, 4164, 4199, 4229, 4269, 4299, 4349], 'Scholar].': [345, 531, 694, 833, 883, 1495, 1556, 1678, 1991, 2106, 2172, 2318, 2426, 2725, 2840, 2906, 3052, 3160, 3383, 3590, 3756, 3887, 4165, 4230, 4300, 4350], 'Over': [346], 'last': [348], 'three': [349, 2254, 2988, 3313], 'decades,': [350], 'prevalence': [352], 'have': [357, 428, 721, 1802, 2109, 2183, 2536, 2843, 2917, 3191], 'rapidly': [359], 'latest': [362], 'World': [363], 'Organization': [365], '(WHO)': [366], 'estimates': [367], 'suggest': [368, 4353], '1.6': [370, 3556], 'billion': [371, 395], 'adults': [372, 402], '(aged': [373], '15': [374], 'years': [375], 'over)': [377], 'were': [378, 383, 2266, 2283, 2331, 3000, 3017, 3065, 3418, 3783, 3812, 3897], '400': [381], 'million': [382, 400], 'obese': [384, 401, 898], '2005.': [386], 'figures': [388], 'predicted': [390, 2275, 3009, 4364], 'rise': [392, 432], '2.3': [394], 'over': [398], '700': [399], '2015': [404], '(http://www.who.int/mediacentre/factsheets/fs311/en/index.html).': [405], 'Obesity': [406], 'is': [407, 533, 788, 863, 942, 1479, 1503, 1536, 1637, 1658, 1680, 1744, 1751, 1775, 2011, 2244, 2478, 2485, 2509, 2745, 2978, 3253, 3395, 3458, 3577, 3743, 3974, 4061, 4118, 4305], 'therefore': [408, 1681], 'major': [410], 'international': [411], 'public': [412, 3916], 'health': [413], 'threat': [414], 'economic': [416], 'burden.': [417], 'Although': [418], 'environmental': [419, 486], 'factors,': [420], 'such': [421], 'little': [423, 3502], 'physical': [424, 990], 'activity': [425, 991, 1418, 1937, 2149, 2671, 2883], 'over-eating,': [427], 'driven': [429], 'recent': [431, 696, 2020, 2754], 'numbers': [435], 'people': [437], 'who': [438], 'obese,': [442], 'genetic': [443, 511, 538, 602, 626, 661, 758, 912, 1357, 1722, 1832, 2055, 2351, 2456, 2566, 2789, 3085, 3428, 3944], 'factors': [444, 487, 539], 'estimated': [446], 'account': [448], '40–90%': [450], 'population': [453, 674, 1293, 1457, 1976, 2411, 2710, 3145], 'variation': [454, 662, 715, 1096, 1159, 1603], 'BMI': [456, 612, 668, 685, 852, 890, 1450, 1502, 1785, 1969, 2179, 2197, 2379, 2404, 2519, 2703, 2913, 2931, 3113, 3138, 3417], '[2Hjelmborg': [457], 'J.B.': [458], 'et': [459, 483, 506, 678, 753, 780, 811, 855, 907, 934, 965, 988, 1014, 1039, 1065, 1094, 1124, 1156, 1183, 1222, 1256, 1282, 1307, 1324, 1354, 1387, 1416, 1444, 1475, 1528, 1650, 1827, 1854, 1877, 1909, 1935, 1963, 2050, 2077, 2116, 2147, 2298, 2346, 2372, 2398, 2561, 2588, 2611, 2643, 2669, 2697, 2784, 2811, 2850, 2881, 3032, 3080, 3106, 3132, 3202, 3228, 3251, 3279, 3302, 3331, 3358, 3423, 3450, 3481, 3525, 3573, 3615, 3639, 3667, 3711, 3739, 3848, 3939, 3966, 3997, 4056, 4089, 4110, 4182, 4252, 4337], 'al.Genetic': [460, 484, 1066, 1184], 'influences': [461], 'growth': [463, 3698], 'traits': [464, 1104, 1337], 'BMI:': [466], 'longitudinal': [468], 'adult': [471, 799, 874, 953, 975, 1547, 1669, 1864, 2308, 2598, 3042, 3310, 3469, 3491, 3985, 4007], 'twins.Obesity.': [472], '2008;': [473, 526, 1004, 1029, 1055, 1085, 1114, 1146, 1174, 1213, 1272, 1298, 1315, 1345, 1377, 1435, 1488, 1899, 1925, 1954, 2099, 2132, 2166, 2633, 2659, 2688, 2833, 2866, 2900, 3218, 3293, 4079, 4128], '16:': [474, 1175, 1299, 1316, 1489], '847-852Crossref': [475], 'PubMed': [476, 499, 773, 804, 829, 879, 927, 958, 981, 1007, 1032, 1058, 1117, 1149, 1249, 1275, 1380, 1468, 1491, 1552, 1674, 1847, 1870, 1902, 1928, 1987, 2070, 2102, 2135, 2314, 2366, 2422, 2581, 2604, 2636, 2662, 2721, 2804, 2836, 2869, 3048, 3100, 3156, 3221, 3244, 3272, 3324, 3351, 3379, 3443, 3474, 3497, 3959, 3990, 4013, 4082, 4103, 4131, 4196, 4266, 4346], '(90)': [478], 'Scholar,': [480, 503, 777, 808, 931, 962, 985, 1011, 1036, 1062, 1091, 1121, 1153, 1180, 1219, 1253, 1279, 1304, 1321, 1351, 1384, 1413, 1441, 1472, 1851, 1874, 1906, 1932, 1960, 2074, 2585, 2608, 2640, 2666, 2694, 2808, 3225, 3248, 3276, 3299, 3328, 3355, 3447, 3478, 3636, 3734, 3963, 3994, 4086, 4107, 4135, 4200, 4270], '3Maes': [481], 'H.H.': [482], 'relative': [489], 'human': [493, 594, 3830, 3894, 3935, 4032, 4116, 4366], 'adiposity.Behav.': [494], 'Genet.': [495, 769, 923, 977, 1054, 1271, 1464, 1843, 1866, 1924, 1983, 2066, 2131, 2310, 2362, 2418, 2577, 2600, 2658, 2717, 2800, 2865, 3044, 3096, 3152, 3217, 3240, 3268, 3292, 3320, 3347, 3375, 3439, 3493, 3955, 4009], '1997;': [496, 3689], '27:': [497], '325-351Crossref': [498], '(1182)': [501], '4Wardle': [504], 'J.': [505, 523, 1027, 1462, 1981, 2416, 2715, 3150, 3666], 'al.Evidence': [507], 'strong': [510, 738], 'influence': [512, 1070, 2438, 3172, 3370], 'childhood': [514, 797, 872, 951, 971, 1545, 1667, 1860, 2304, 2594, 3038, 3467, 3487, 3983, 4003], 'despite': [516, 648, 2320, 3054], 'force': [518], 'obesogenic': [521], 'environment.Am.': [522], 'Clin.': [524, 3881], 'Nutr.': [525], '87:': [527], '398-404Scopus': [528], '(525)': [529], 'It': [532, 1679, 2243, 2977], 'hoped': [534], 'identifying': [536, 724, 3194], 'heritable': [542], 'contribute': [547], 'our': [549], 'basic': [550], 'biology': [554], 'balance,': [557], 'might': [559, 2221, 2433, 2443, 2955, 3167, 3177, 4356], 'even': [560], 'highlight': [561, 3367], 'molecules': [562], 'pathways': [564], 'can': [566, 3387, 4319], 'be': [567, 590, 1594, 2294, 2334, 3028, 3068, 3388], 'targeted': [568], 'therapeutic': [570], 'intervention.': [571], 'within': [578, 1566, 1792, 1808, 2526, 2542, 3554], 'became': [586], 'reproducibly': [592, 727], 'mass.': [596], 'We': [597, 632], 'implications': [600], 'between': [604, 707, 740, 841, 886, 1598, 1711, 1755, 1762, 1784, 2199, 2235, 2489, 2496, 2518, 2933, 2969, 3412], 'humans,': [614], 'various': [616], 'undertaken': [618], 'challenges': [621], 'progressing': [623], 'from': [624, 1205, 2028, 2380, 2762, 3114, 3264, 3889], 'new': [629, 3314, 3335, 3360, 3869], 'insight.': [631], 'also': [633, 1633, 4363], 'overview': [636], 'possible': [638, 1682], 'future': [639, 2445, 3179], 'directions': [640], 'research': [642, 4020], 'field.': [645], 'Before': [646, 3384], 'huge': [649], 'efforts': [650], 'using': [651, 1995, 2729, 4239], 'genome-wide': [652, 681, 699, 813, 3261], 'linkage': [653, 682, 1571, 1715, 2449], 'candidate': [656], 'studies,': [659], 'no': [660, 3758], 'had': [663, 2213, 2947], 'been': [664, 900, 2110, 2215, 2844, 2949], '[5Saunders': [676], 'C.L.': [677], 'al.Meta-analysis': [679], 'obesity.Obesity.': [687], '15:': [689], '2263-2275Crossref': [690], '(118)': [692], 'years,': [697], 'however,': [698, 3393], '(GWAS),': [702], 'which': [703, 1778, 2442, 2512, 3176, 3403, 4318], 'test': [704, 1731, 2465], 'correlation': [706, 1597, 1754, 2488], 'across': [709], 'entire': [711], 'genome': [712], 'trait': [714], 'sample': [718], 'individuals,': [720], 'succeeded': [722, 3192], 'variants': [725, 759, 913, 1041, 1067, 1358, 1389, 1426, 1448, 1768, 1833, 1945, 1967, 2056, 2157, 2352, 2402, 2436, 2502, 2567, 2679, 2701, 2790, 2891, 3086, 3136, 3170, 3204, 3233, 3337, 3407, 3429, 3945], 'complex': [729], 'traits.': [730], 'GWAS': [731, 3190], 'diabetes': [735, 819, 1191, 1200, 1371, 1395], '(T2D)': [736], 'detected': [737], 'common': [741, 782, 857, 936, 1142, 1423, 1530, 1652, 1895, 1942, 2095, 2154, 2629, 2676, 2829, 2888, 3452, 3968], 'T2D': [750, 845], '[6Scuteri': [751, 905, 1825, 2048, 2344, 2559, 2782, 3078, 3421, 3937], 'A.': [752, 906, 1155, 1221, 1443, 1826, 1962, 2049, 2345, 2397, 2560, 2696, 2783, 3079, 3131, 3422, 3938], 'al.Genome-wide': [754, 908, 1828, 2051, 2347, 2562, 2785, 3081, 3280, 3303, 3332, 3424, 3940], 'scan': [756, 910, 1830, 2053, 2349, 2564, 2787, 3083, 3426, 3942], 'shows': [757, 911, 1831, 2054, 2350, 2565, 2788, 3084, 3427, 3943], 'obesity-related': [767, 921, 1841, 2064, 2360, 2575, 2798, 3094, 3437, 3953], 'traits.PLoS': [768, 922, 1842, 2065, 2361, 2576, 2799, 3095, 3438, 3954], '3:': [771, 925, 1147, 1346, 1845, 1900, 2068, 2100, 2364, 2579, 2634, 2802, 2834, 3098, 3441, 3957], 'e115Crossref': [772, 926, 1846, 2069, 2365, 2580, 2803, 3099, 3442, 3958], '(1346)': [775, 929, 1849, 2072, 2368, 2583, 2806, 3102, 3445, 3961], '7Frayling': [778, 932, 3448, 3964], 'T.M.': [779, 854, 933, 1527, 1649, 3449, 3965], 'al.A': [781, 812, 856, 935, 1529, 1651, 3451, 3967], 'variant': [783, 858, 937, 1019, 1531, 1653, 3453, 3969], 'predisposes': [795, 870, 949, 1543, 1665, 3465, 3981], 'obesity.Science.': [800, 875, 954, 1548, 1670, 3470, 3986], '316:': [802, 827, 877, 956, 1550, 1672, 3472, 3988], '889-894Crossref': [803, 878, 957, 1551, 1673, 3473, 3989], '(3468)': [806, 881, 960, 1554, 1676, 3476, 3992], '8Scott': [809], 'L.J.': [810], 'Finns': [821], 'detects': [822], 'susceptibility': [824, 2439, 3173, 3406], 'variants.Science.': [825], '1341-1345Crossref': [828], '(2296)': [831], 'However,': [834, 3757], 'subsequent': [835], 'showed': [837, 4168], 'mediated': [847], '[7Frayling': [853, 1526], 'The': [884, 1496, 1992, 2726, 3926, 4140, 4205, 4275], 'being': [895], 'has': [899], 'confirmed': [901, 3404], 'populations': [904, 1821, 2015, 2182, 2555, 2749, 2916], '9Dina': [963, 1852, 2586, 3479, 3995], 'C.': [964, 1853, 2297, 2587, 3031, 3227, 3480, 3996], 'al.Variation': [966, 1855, 2299, 2589, 3033, 3482, 3998], 'contributes': [969, 1858, 2302, 2592, 3036, 3485, 4001], 'severe': [974, 1265, 1863, 1918, 2125, 2307, 2597, 2652, 2859, 3041, 3490, 3600, 4006], 'obesity.Nat.': [976, 1053, 1865, 2309, 2599, 3043, 3216, 3346, 3492, 4008], '39:': [979, 1868, 2312, 2602, 3046, 3495, 4011], '724-726Crossref': [980, 1869, 2313, 2603, 3047, 3496, 4012], '(1281)': [983, 1872, 2316, 2606, 3050, 3499, 4015], '10Andreasen': [986], 'C.H.': [987], 'al.Low': [989], 'accentuates': [992], 'rs9939609': [998], 'polymorphism': [999], 'accumulation.Diabetes.': [1003], '57:': [1005, 1086, 1115, 1378], '95-101Crossref': [1006], '(415)': [1009], '11Cecil': [1012], 'J.E.': [1013], 'al.An': [1015], 'intake': [1023], 'children.N.': [1025], 'Engl.': [1026], 'Med.': [1028, 1434, 1953, 2165, 2687, 2899], '359:': [1030], '2558-2566Crossref': [1031], '(546)': [1034], '12Loos': [1037], 'R.J.': [1038, 3201], 'al.Common': [1040, 1095, 1388, 3203, 3229], 'near': [1042, 1359, 3205], 'MC4R': [1043, 3206], 'mass,': [1048, 3211], '40:': [1056, 3219], '768-775Crossref': [1057, 3220], '(1047)': [1060, 3223], '13Do': [1063], 'R.': [1064, 4055], 'adiposity,': [1071], 'insulin': [1072], 'sensitivity,': [1073], 'leptin': [1074], 'levels,': [1075], 'resting': [1077], 'metabolic': [1078, 1103, 1336], 'rate': [1079], 'Quebec': [1082], 'Family': [1083], 'Study.Diabetes.': [1084], '1147-1150Crossref': [1087], '(198)': [1089], '14Freathy': [1092], 'R.M.': [1093], 'alters': [1101], 'diabetes-related': [1102], 'extent': [1107], 'expected': [1108], 'given': [1109, 1736, 2470], 'its': [1110, 4024, 4315], 'BMI.Diabetes.': [1113], '1419-1426Crossref': [1116], '(265)': [1119], '15Grant': [1122, 1875, 2075, 2609, 2809], 'S.F.': [1123, 1876, 2076, 2610, 2810], 'al.Association': [1125, 1308, 1445, 1878, 1964, 2078, 2399, 2612, 2698, 2812, 3133], 'analysis': [1126, 1185, 1879, 2079, 2613, 2813, 4167, 4362], 'children': [1134, 1887, 2087, 2621, 2821], 'Caucasian': [1136, 1889, 2089, 2623, 2823], 'African': [1138, 1891, 2017, 2033, 2091, 2625, 2751, 2767, 2825], 'ancestry': [1139, 1824, 1892, 2000, 2092, 2558, 2626, 2734, 2826], 'reveals': [1140, 1893, 2093, 2627, 2827], 'tagging': [1143, 1806, 1896, 2096, 2335, 2540, 2630, 2830, 3069], 'SNP.PloS': [1144, 1897, 2097, 2631, 2831], 'ONE.': [1145, 1245, 1344, 1898, 2098, 2632, 2832], 'e1746Crossref': [1148, 1901, 2101, 2635, 2835], '(164)': [1151, 1904, 2104, 2638, 2838], '16Haupt': [1154], 'al.Impact': [1157], 'whole': [1165], 'distribution,': [1168], 'ectopic': [1169], 'fat,': [1170], 'loss.Obesity.': [1173], '1969-1972Crossref': [1176], '(104)': [1178], '17Hertel': [1181], 'J.K.': [1182], 'recently': [1187], 'loci': [1192, 3199, 3316, 3340, 3361], '1,638': [1194], 'unselected': [1195], 'patients': [1196], '1,858': [1202], 'control': [1203, 1609], 'participants': [1204, 2144, 2878], 'Norwegian': [1207], 'population-based': [1208], 'cohort': [1209], '(the': [1210, 3781], 'HUNT': [1211], 'study).Diabetologia.': [1212], '51:': [1214], '971-977Crossref': [1215], '(79)': [1217], '18Hinney': [1220], 'al.Genome': [1223], 'wide': [1224], '(GWA)': [1226], 'early': [1229], 'onset': [1230], 'extreme': [1231, 3237], 'supports': [1233], 'variants.PloS': [1244], '2:': [1247], 'e1361Crossref': [1248], '(431)': [1251], '19Hotta': [1254, 1907, 2641], 'K.': [1255, 1908, 2115, 2642, 2849, 3638], 'al.Variations': [1257, 1910, 2117, 2644, 2851], 'Japanese.J.': [1269, 1922, 2129, 2656, 2863], 'Hum.': [1270, 1463, 1923, 1982, 2130, 2417, 2657, 2716, 2864, 3151], '53:': [1273, 1926, 2133, 2660, 2867], '546-553Crossref': [1274, 1927, 2134, 2661, 2868], '(209)': [1277, 1930, 2137, 2664, 2871], '20Hubacek': [1280], 'J.A.': [1281], 'al.The': [1283, 1476, 3668, 4057, 4090, 4111, 4183, 4253], 'large': [1290], 'Eastern': [1291], 'European': [1292, 2250, 2984, 3318], 'sample:': [1294], 'HAPIEE': [1296], 'study.Obesity.': [1297], '2764-2766Crossref': [1300], '(64)': [1302, 1349], '21Hunt': [1305], 'S.C.': [1306, 4336], 'BMI.Obesity.': [1314], '902-904Crossref': [1317], '(129)': [1319], '22Kring': [1322], 'S.I.': [1323], 'al.FTO': [1325], 'fatness': [1328], 'relation': [1330], 'distribution': [1334], 'throughout': [1338], 'broad': [1340], 'range': [1341], 'fatness.PloS': [1343], 'e2958Crossref': [1347], '23Ng': [1352], 'M.C.': [1353], 'al.Implication': [1355], 'TCF7L2,': [1360], 'SLC30A8,': [1361], 'HHEX,': [1362], 'CDKAL1,': [1363], 'CDKN2A/B,': [1364], 'IGF2BP2,': [1365], '6,719': [1375], 'Asians.Diabetes.': [1376], '2226-2233Crossref': [1379], '(308)': [1382], '24Pascoe': [1385], 'L.': [1386, 4137, 4202, 4272], 'novel': [1392, 3197, 3255, 3287, 3531, 3581, 3717, 3747, 4151, 4216, 4286], 'CDKAL1': [1397], 'HHEX/IDE': [1399], 'decreased': [1403], 'pancreatic': [1404], 'beta-cell': [1405], 'function.Diabetes.': [1406], '56:': [1408], '3101-3104Crossref': [1409], '(205)': [1411], '25Rampersaud': [1414, 1933, 2667], 'E.': [1415, 1934, 2146, 2668, 2880], 'al.Physical': [1417, 1936, 2148, 2670, 2882], 'obesity.Arch.': [1432, 1951, 2163, 2685, 2897], 'Int.': [1433, 1952, 2164, 2686, 2898], '168:': [1436, 1955, 2167, 2689, 2901], '1791-1797Crossref': [1437, 1956, 2168, 2690, 2902], '(222)': [1439, 1958, 2170, 2692, 2904], '26Tonjes': [1442, 1961, 2695], 'self-contained': [1456, 1975, 2410, 2709, 3144], 'Sorbs': [1459, 1978, 2413, 2712, 3147], 'Germany.Eur.': [1461, 1980, 2415, 2714, 3149], '2010;': [1465, 1984, 2419, 2718, 3153], '18:': [1466, 1985, 2420, 2719, 3154, 3242], '104-110Crossref': [1467, 1986, 2421, 2720, 3155], '(76)': [1470, 1989, 2424, 2723, 3158], '27Villalobos-Comparan': [1473], 'M.': [1474], 'adulthood': [1482], 'Mexican': [1486], 'population.Obesity.': [1487], '2296-2301Crossref': [1490], '(145)': [1493], 'modest,': [1504], 'those': [1506, 1520], 'individuals': [1507, 2031, 2395, 2765, 3129], 'homozygous': [1508, 1521, 3592], 'allele': [1512, 1525], 'weighing,': [1513], 'average,': [1515], '3': [1516], 'kg': [1517], 'more': [1518], 'than': [1519, 2340, 3074], 'protective': [1524], 'Association': [1557], 'does': [1558, 1727, 2461], 'necessarily': [1560], 'mean': [1561], 'causation.': [1562], 'BMI-associated': [1563], 'lie': [1565], '47': [1568, 1794, 2528], 'kilobase': [1569], '(kb)': [1570], 'disequilibrium': [1572, 1716, 2450], '(LD)': [1573, 1717, 2451], 'block': [1574], 'encompassing': [1575], 'parts': [1576], 'two': [1580, 3795], 'introns': [1581, 2384, 3118], 'well': [1583], 'exon': [1585], 'FTO.': [1588, 3908], 'Thus,': [1589], 'signal': [1592, 1701, 2027, 2338, 2761, 3072], 'could': [1593, 2292, 3026], 'due': [1595, 3813], 'intronic': [1600], 'elsewhere': [1604], 'elements': [1610], 'Indeed,': [1614], 'transcription': [1616], 'start': [1617], 'site': [1618], 'retinitis': [1621], 'pigmentosa': [1622], 'GTPase': [1623], 'regulator-interacting': [1624], 'protein': [1625], '1-like': [1626], '(RPGRIP1L)': [1627], '(homolog': [1629], 'murine': [1631], 'Rpgrip1l,': [1632], 'Ftm)': [1636], 'close': [1639], 'proximity': [1640], '(∼400': [1641], 'bp)': [1642], "5'": [1645], 'end': [1646], 'FTO[7Frayling': [1648], 'RPGRIP1L.': [1695], 'Efforts': [1696], 'fine-map': [1698], 'causative': [1703], 'variant(s)': [1704, 1733, 1780, 2228, 2467, 2514, 2962], 'underway': [1706], '(Box': [1707], '1).Box': [1708], '1Fine-mapping': [1709], 'obesityWhereas': [1714], 'aids': [1718, 2452], 'discovery': [1720, 2454, 3184, 3927], 'associations,': [1723, 2457], 'because': [1724, 1752, 2458, 2486], 'investigator': [1726, 2460], 'need': [1729, 2463], 'all': [1732, 2466], 'genomic': [1737, 1811, 2431, 2471, 2545, 3165], 'detect': [1740, 2474], 'signals,': [1742, 2476], 'hindrance': [1746, 2480], 'fine-mapping': [1748, 1800, 2251, 2446, 2482, 2534, 2985, 3180], 'efforts.': [1749, 2483], 'This': [1750, 2220, 2427, 2484, 2954, 3161], 'high': [1753, 2487], 'makes': [1757, 2491], 'difficult': [1759, 2493], 'distinguish': [1761, 2495], 'effects': [1764, 2291, 2498, 3025, 3906], 'true': [1766, 2500], 'causal': [1767, 1779, 2227, 2241, 2501, 2513, 2961, 2975], 'correlated': [1770, 2285, 2504, 3019], 'non-causal': [1771, 2505], 'variants.': [1772, 2506], 'Consequently,': [1773, 2507], 'clear': [1777, 2511], 'underlie': [1781, 2515], '(which': [1790, 2524], 'reside': [1791, 2525], 'kb': [1795, 2529], 'LD': [1796, 2010, 2234, 2530, 2744, 2968], 'block).': [1797, 2531], 'So': [1798, 2532], 'far,': [1799, 2533], 'attempts': [1801, 2535], 'focused': [1803, 2537], 'selecting': [1805, 2539], 'genotyping': [1814, 2548], 'imputing': [1816, 2550], 'additional': [1819, 2553, 3189, 3196], 'different': [1823, 1999, 2557, 2733], 'advantage': [1993, 2727], 'cohorts': [1997, 2047, 2731, 2781], 'lies': [2001, 2735], 'varying': [2004, 2738], 'patterns': [2005, 2739], 'LD.': [2007, 2741], 'For': [2008, 2201, 2742, 2935], 'example,': [2009, 2202, 2743, 2936], 'generally': [2012, 2746], 'weaker': [2013, 2747], 'descent.': [2018, 2752], 'Two': [2019, 2753], 'attempted': [2022, 2756], 'refine': [2024, 2758], 'ancestry,': [2034, 2768], 'but': [2035, 2190, 2280, 2769, 2924, 3014], 'none': [2036, 2770], 'tested': [2040, 2236, 2774, 2970], 'both': [2046, 2780], 'Fine-mapping': [2107, 2841], 'done': [2111, 2845], 'Japanese': [2113, 2847], '[19Hotta': [2114, 2848], 'Scholar]': [2139, 2873, 3548, 4017], 'Old': [2141, 2209, 2875, 2943], 'Amish': [2142, 2210, 2876, 2944], 'Order': [2143, 2211, 2877, 2945], '[25Rampersaud': [2145, 2879], 'Some': [2173, 2907], 'overlapped': [2184, 2918], 'Europeans': [2189, 2923], 'most': [2193, 2258, 2927, 2992, 4306], 'strongly': [2194, 2928], 'vary': [2198, 2932], 'cohorts.': [2200, 2934], 'strongest': [2204, 2938], 'SNP': [2205, 2939], '(rs1861868)': [2206, 2940], 'previously': [2216, 2950], 'obesity.': [2219, 2953], 'reflect': [2222, 2956], 'interstudy': [2223, 2957], 'differences': [2224, 2230, 2958, 2964], 'levels': [2232, 2966], 'same': [2240, 2337, 2974, 3071], 'variant(s).': [2242, 2976], 'worth': [2245, 2979], 'mentioning': [2246, 2980], 'cohort,': [2253, 2987], 'four': [2257, 2991], 'significantly': [2259, 2993], '(rs17817449,': [2262, 2996], 'rs3751812': [2263, 2997], 'rs1421085)': [2265, 2999], 'putative': [2268, 3002], 'functional': [2269, 3003, 4025], 'regions': [2270, 3004], '(based': [2271, 3005], 'conservation': [2273, 3007], 'impact': [2276, 3010, 3408], 'regulatory': [2278, 3012], 'domains)': [2279, 3013], 'highly': [2284, 3018], 'each': [2287, 3021], 'distinguished': [2295, 3029], '[9Dina': [2296, 3030], 'Interestingly,': [2319, 3053, 3817], 'earlier': [2322, 3056], 'demonstration': [2323, 3057], 'likely': [2332, 3066], 'rather': [2339, 3073], 'multiple,': [2341, 3075], 'independent': [2342, 2376, 3076, 3110], 'signals': [2343, 3077], 'Scholar],': [2370, 3104, 3501, 3661, 3695], 'Tonjes': [2371, 3105], 'al.': [2373, 3107], 'discovered': [2374, 3108, 3420], '3,': [2387, 3121], 'downstream': [2388, 3122], 'original': [2391, 3125], 'signal,': [2392, 3126, 3188], 'Sorbian': [2394, 3128], '[26Tonjes': [2396, 3130], 'suggests': [2428, 3162, 3680], 'harbor': [2434, 3168], 'complicate': [2444, 3178], 'attempts.': [2447, 3181], 'Whereas': [2448], 'Since': [3182], '[12Loos': [3200], '28Cotsapas': [3226], 'index-associated': [3232], 'confer': [3234], 'obesity.Hum.': [3238, 3290], 'Mol.': [3239, 3291, 4126], '2009;': [3241, 3269, 3321, 3348, 3376], '3502-3507Crossref': [3243], '(86)': [3246], '29Heard-Costa': [3249], 'N.L.': [3250], 'al.NRXN3': [3252], 'waist': [3258], 'circumference:': [3259], 'CHARGE': [3266], 'Consortium.PLoS': [3267], '5:': [3270], 'e1000539Crossref': [3271], '(218)': [3274], '30Liu': [3277], 'Y.J.': [3278], 'scans': [3282], 'CTNNBL1': [3284], '17:': [3294], '1803-1813Crossref': [3295], '(142)': [3297], '31Meyre': [3300], 'D.': [3301], 'early-onset': [3307], 'morbid': [3309], 'identifies': [3312], 'populations.Nat.': [3319], '41:': [3322, 3349, 3377], '157-159Crossref': [3323], '(522)': [3326], '32Thorleifsson': [3329], 'G.': [3330], 'yields': [3334], 'sequence': [3336, 4034], 'at': [3338, 3414, 4022], 'seven': [3339], 'associate': [3342], 'measures': [3344], '18-24Crossref': [3350], '(1093)': [3353], '33Willer': [3356], 'C.J.': [3357], 'al.Six': [3359], 'neuronal': [3369], 'regulation.Nat.': [3374], '25-34Crossref': [3378], '(1407)': [3381], 'findings': [3386], 'converted': [3389], 'into': [3390], 'clinical': [3391], 'benefits,': [3392], 'necessary': [3396], 'determine': [3398], 'BMI.': [3409], 'When': [3410], 'associations': [3411], 'about': [3505], 'product.': [3512], 'Fto': [3513, 3769, 3815], 'mouse': [3519, 3539, 3582, 3625, 3677, 3725, 3748, 3780, 3892], 'positional': [3521], 'cloning': [3522], '[34Peters': [3523, 3709], 'T.': [3524, 3710, 4088, 4181, 4251], 'al.Cloning': [3526, 3712], 'Fatso': [3528, 3714], '(Fto),': [3529, 3715], 'deleted': [3533, 3719, 3776], 'Fused': [3536, 3565, 3584, 3627, 3722, 3750], 'toes': [3537, 3566, 3585, 3703, 3723, 3751], '(Ft)': [3538, 3567, 3724], 'mutation.Mamm.': [3540, 3726], 'Genome.': [3541, 3727], '1999;': [3542, 3728], '10:': [3543, 3729], '983-986Crossref': [3544, 3730], '(139)': [3546, 3732], 'one': [3550, 3772], 'megabase': [3557], 'deletion': [3558, 3595], 'chromosome': [3560, 3855], '8': [3561], 'responsible': [3562], 'phenotype': [3568, 3819], '[35van': [3569], 'der': [3570, 3736], 'Hoeven': [3571, 3737], 'F.': [3572, 3738], 'al.Programmed': [3574, 3740], 'cell': [3575, 3741], 'affected': [3578, 3644, 3744], 'mutant': [3583, 3626, 3678, 3749], '(Ft).Development.': [3586, 3752], '1994;': [3587, 3753], '120:': [3588, 3754], '2601-2607Google': [3589, 3755], 'Mice': [3591], 'died': [3596], 'mid-gestation': [3597], 'exhibited': [3599], 'malformations': [3601], 'head': [3604, 3621], 'face,': [3606], 'central': [3607], 'nervous': [3608], 'system': [3609], '(CNS)': [3610], 'developmental': [3611], 'defects': [3612], '[36Anselme': [3613], 'I.': [3614], 'al.Defects': [3616], 'brain': [3618], 'patterning': [3619], 'morphogenesis': [3622], 'toes.Dev.': [3628], 'Biol.': [3629], '304:': [3631], '208-220Crossref': [3632], '(51)': [3634], '37Gotz': [3637], 'al.Homozygous': [3640], 'Ft': [3641, 3679, 3779, 3824, 3891], 'embryos': [3642], 'floor': [3646], 'plate': [3647], 'maintenance': [3648], 'ventral': [3650], 'neural': [3651], 'tube': [3652], 'patterning.Dev.': [3653], 'Dyn.': [3654], '2005;': [3655, 4343], '233:': [3656], '623-630Crossref': [3657], '(16)': [3659], 'randomized': [3662], 'left–right': [3663], 'asymmetry': [3664], '[38Heymer': [3665], 'expression': [3669], 'pattern': [3670], 'nodal': [3672], 'lefty': [3674], 'establishment': [3685], 'handedness.Mech.': [3687], 'Dev.': [3688], '66:': [3690, 4129], '5-11Crossref': [3691], '(60)': [3693], 'polydactyly': [3696], 'retardation.': [3699], 'Heterozygotes': [3700], 'displayed': [3701], 'fused': [3702], 'enlargement': [3705], 'thymus': [3708], '35van': [3735], 'thinness': [3761], 'reported': [3763], 'mice.': [3766], 'Nevertheless,': [3767], 'only': [3771, 4120], 'six': [3774], 'others': [3782], 'Iroquois': [3785], 'B': [3786], 'cluster': [3787], 'genes,': [3789, 3797], 'Irx3,': [3790], 'Irx5': [3791], 'Irx6,': [3793], 'Fts': [3798], 'Rpgrip1l),': [3800], 'which,': [3805], 'if': [3806], 'any,': [3807], 'phenotypic': [3810], 'manifestations': [3811], 'deficiency.': [3816], 'similar': [3820, 4307], 'mice': [3825], 'seen': [3827], 'patient': [3831], 'harboring': [3832], 'small': [3834], 'chromosomal': [3835, 3895], 'duplication': [3836, 3853, 3896], '16q12.2,': [3838], 'includes': [3842], '[39Stratakis': [3846], 'C.A.': [3847], 'al.Anisomastia': [3849], 'interstitial': [3852], '16,': [3856], 'mental': [3857], 'retardation,': [3858], 'dysmorphic': [3860], 'facies,': [3861], 'digital': [3863], 'anomalies:': [3864], 'molecular': [3865], 'mapping': [3866], 'syndrome': [3870], 'fluorescent': [3872], 'situ': [3874], 'hybridization': [3875], 'microsatellites': [3877], '16q13': [3879], '(D16S419-D16S503).J.': [3880], 'Endocrinol.': [3882], 'Metab.': [3883], '2000;': [3884], '85:': [3885], '3396-3401Google': [3886], 'Clues': [3888], 'sufficient': [3899], 'shed': [3901], 'light': [3902], 'specific': [3905], 'Moreover,': [3909], 'annotated': [3913], 'databases': [3917], 'having': [3919], 'homology': [3920], 'any': [3922], 'gene.': [3925], 'mysterious': [3930], 'further': [4019], 'aimed': [4021], 'elucidating': [4023], 'properties.': [4026], 'silico': [4028], 'revealed': [4035], 'homologs': [4036], 'vertebrates': [4039, 4122], '(from': [4040, 4047], 'fish': [4041], 'mammals)': [4043], 'marine': [4045, 4124], 'algae': [4046], 'unicellular': [4048], 'photosynthetic': [4049], 'picoplankton': [4050], 'multicellular': [4052], 'seaweed)': [4053], '[40Fredriksson': [4054], 'gene,': [4059, 4113], 'FTO,': [4060], 'ancient': [4063], 'origin,': [4064], 'up-regulated': [4065], 'during': [4066], 'food': [4067], 'deprivation': [4068], 'expressed': [4070], 'neurons': [4072], 'feeding-related': [4074], 'nuclei': [4075], 'brain.Endocrinology.': [4078], '149:': [4080], '2062-2071Crossref': [4081], '(304)': [4084], '41Gerken': [4087], 'encodes': [4094, 4187, 4257], '2-oxoglutarate-dependent': [4096, 4189, 4259], 'nucleic': [4097, 4190, 4260], 'acid': [4098, 4191, 4261], 'demethylase.Science.': [4099, 4192, 4262], '318:': [4101, 4194, 4264], '1469-1472Crossref': [4102, 4195, 4265], '(1204)': [4105, 4198, 4268], '42Robbens': [4108], 'S.': [4109], 'implicated': [4114], 'found': [4119], 'algae.J.': [4125], 'Evol.': [4127], '80-84Crossref': [4130], '(53)': [4133], '43Sanchez-Pulido': [4136, 4201, 4271], 'Andrade-Navarro': [4138, 4203, 4273], 'M.A.': [4139, 4204, 4274], '(fat': [4142, 4207, 4277], 'associated)': [4146, 4211, 4281], 'codes': [4148, 4213, 4283], 'member': [4152, 4217, 4287], 'non-heme': [4155, 4220, 4240, 4290], 'dioxygenase': [4156, 4221, 4291], 'superfamily.BMC': [4157, 4222, 4292], 'Biochem.': [4158, 4223, 4293], '23Crossref': [4161, 4226, 4296], '(162)': [4163, 4228, 4298, 4348], 'Sequence': [4166, 4361], 'shares': [4171], 'features': [4172], 'Fe': [4174], '(II)': [4175], '2-oxoglutarate': 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'cited_by_count': 25}, {'year': 2021, 'cited_by_count': 24}, {'year': 2020, 'cited_by_count': 23}, {'year': 2019, 'cited_by_count': 27}, {'year': 2018, 'cited_by_count': 24}, {'year': 2017, 'cited_by_count': 19}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 27}, {'year': 2014, 'cited_by_count': 26}, {'year': 2013, 'cited_by_count': 29}, {'year': 2012, 'cited_by_count': 28}], 'updated_date': '2024-12-12T03:38:08.266747', 'created_date': '2016-06-24'}
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