Title: Reversible Splenial Lesion Syndrome (RESLES): What's in a Name?
Abstract: Journal of NeuroimagingVolume 21, Issue 2 p. e1-e14 Views and Reviews Reversible Splenial Lesion Syndrome (RESLES): What's in a Name? Juan Carlos Garcia-Monco MD, Juan Carlos Garcia-Monco MD Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC).Search for more papers by this authorInes Escalza Cortina MD, Ines Escalza Cortina MD Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC).Search for more papers by this authorEva Ferreira MD, Eva Ferreira MD Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC).Search for more papers by this authorAmaia Martínez MD, Amaia Martínez MD Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC).Search for more papers by this authorLara Ruiz MD, Lara Ruiz MD Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC).Search for more papers by this authorAlberto Cabrera MD, Alberto Cabrera MD Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC).Search for more papers by this authorMarian Gomez Beldarrain MD, Marian Gomez Beldarrain MD Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC).Search for more papers by this author Juan Carlos Garcia-Monco MD, Juan Carlos Garcia-Monco MD Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC).Search for more papers by this authorInes Escalza Cortina MD, Ines Escalza Cortina MD Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC).Search for more papers by this authorEva Ferreira MD, Eva Ferreira MD Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC).Search for more papers by this authorAmaia Martínez MD, Amaia Martínez MD Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC).Search for more papers by this authorLara Ruiz MD, Lara Ruiz MD Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC).Search for more papers by this authorAlberto Cabrera MD, Alberto Cabrera MD Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC).Search for more papers by this authorMarian Gomez Beldarrain MD, Marian Gomez Beldarrain MD Servicio de Neurologia, Hospital de Galdacano, Vizcaya, Spain (JCG, IEC, EF, AM, LR, MGB); and Magnetic Resonance Unit, Osatek, Galdacano, Vizcaya, Spain (AC).Search for more papers by this author First published: 24 March 2011 https://doi.org/10.1111/j.1552-6569.2008.00279.xCitations: 147 Correspondence: Address correspondence to Juan Carlos Garcia-Monco, MD, Servicio de Neurologia, Hospital de Galdacano, 48960 Vizcaya, Spain. E-mail: [email protected]. Conflict of Interest: The authors report no conflicts of interest. J Neuroimaging 2011;21:e1-e14. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract ABSTRACT BACKGROUND The presence of transient lesions involving the splenium of the corpus callosum (SCC) has been described in patients with encephalitis or encephalopathy of varied etiology. We have termed it RESLES (reversible splenial lesion syndrome). PURPOSE To describe 3 additional patients (2 encephalitis, 1 hypoglycemia) and review the literature to define this syndrome, its etiology, presentation, prognosis, and possible pathophysiological mechanisms. METHODS Search of the MEDLINE database from 1966 through 2007. English language article titles and abstracts were screened and the appropriate articles reviewed. Additional articles cited by original references were also reviewed. RESULTS RESLES is caused by antiepileptic drug withdrawal, infection, high-altitude cerebral edema (HACE), or metabolic disorders (hypoglycemia and hypernatremia). Complete resolution after a variable lapse is the rule. Clinical presentation is nonspecific, without evidence of callosal disconnection syndromes. Neuroimaging shows a nonenhancing, round-shaped lesion centered in the SCC that disappears after a variable lapse. Diffusion studies reveal DW hypersignal with low ADC values, suggestive of cytotoxic edema. Only HACE-related cases and 1 patient with pregabalin withdrawal showed high ADC values, consistent with vasogenic edema. CONCLUSION RESLES is a distinct clinicoradiological syndrome of varied etiology and benign course except in those patients with an underlying severe disorder. Citing Literature Volume21, Issue2April 2011Pages e1-e14 RelatedInformation
Publication Year: 2010
Publication Date: 2010-06-18
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 217
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