Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2155839154', 'doi': 'https://doi.org/10.1093/bioinformatics/bts515', 'title': 'GFOLD: a generalized fold change for ranking differentially expressed genes from RNA-seq data', 'display_name': 'GFOLD: a generalized fold change for ranking differentially expressed genes from RNA-seq data', 'publication_year': 2012, 'publication_date': '2012-08-24', 'ids': {'openalex': 'https://openalex.org/W2155839154', 'doi': 'https://doi.org/10.1093/bioinformatics/bts515', 'mag': '2155839154', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22923299'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/bioinformatics/bts515', 'pdf_url': 'https://academic.oup.com/bioinformatics/article-pdf/28/21/2782/48875974/bioinformatics_28_21_2782.pdf', 'source': {'id': 'https://openalex.org/S52395412', 'display_name': 'Bioinformatics', 'issn_l': '1367-4803', 'issn': ['1367-4803', '1367-4811'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/bioinformatics/article-pdf/28/21/2782/48875974/bioinformatics_28_21_2782.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101945559', 'display_name': 'Jianxing Feng', 'orcid': 'https://orcid.org/0000-0002-4180-3323'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jianxing Feng', 'raw_affiliation_strings': ['1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 20092, China, 2Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, 220 Handan Road, Shanghai, 200433, China, 3Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Harvard University and 4Department of Statistics, Harvard University, Science Center 715, 1 Oxford Street, Cambridge, MA 02138, USA'], 'affiliations': [{'raw_affiliation_string': '1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 20092, China, 2Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, 220 Handan Road, Shanghai, 200433, China, 3Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Harvard University and 4Department of Statistics, Harvard University, Science Center 715, 1 Oxford Street, Cambridge, MA 02138, USA', 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I116953780', 'https://openalex.org/I4210117453', 'https://openalex.org/I24943067']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021521447', 'display_name': 'Clifford A. Meyer', 'orcid': 'https://orcid.org/0000-0002-8321-2839'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Clifford A. Meyer', 'raw_affiliation_strings': ['1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 20092, China, 2Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, 220 Handan Road, Shanghai, 200433, China, 3Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Harvard University and 4Department of Statistics, Harvard University, Science Center 715, 1 Oxford Street, Cambridge, MA 02138, USA'], 'affiliations': [{'raw_affiliation_string': '1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 20092, China, 2Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, 220 Handan Road, Shanghai, 200433, China, 3Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Harvard University and 4Department of Statistics, Harvard University, Science Center 715, 1 Oxford Street, Cambridge, MA 02138, USA', 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I116953780', 'https://openalex.org/I4210117453', 'https://openalex.org/I24943067']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100322864', 'display_name': 'Li Wang', 'orcid': 'https://orcid.org/0000-0001-8599-7249'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Qian Wang', 'raw_affiliation_strings': ['1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 20092, China, 2Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, 220 Handan Road, Shanghai, 200433, China, 3Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Harvard University and 4Department of Statistics, Harvard University, Science Center 715, 1 Oxford Street, Cambridge, MA 02138, USA'], 'affiliations': [{'raw_affiliation_string': '1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 20092, China, 2Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, 220 Handan Road, Shanghai, 200433, China, 3Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Harvard University and 4Department of Statistics, Harvard University, Science Center 715, 1 Oxford Street, Cambridge, MA 02138, USA', 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I116953780', 'https://openalex.org/I4210117453', 'https://openalex.org/I24943067']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012820890', 'display_name': 'Jun S. Liu', 'orcid': 'https://orcid.org/0000-0002-4450-7239'}, 'institutions': [{'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Jun S. Liu', 'raw_affiliation_strings': ['1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 20092, China, 2Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, 220 Handan Road, Shanghai, 200433, China, 3Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Harvard University and 4Department of Statistics, Harvard University, Science Center 715, 1 Oxford Street, Cambridge, MA 02138, USA'], 'affiliations': [{'raw_affiliation_string': '1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 20092, China, 2Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, 220 Handan Road, Shanghai, 200433, China, 3Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Harvard University and 4Department of Statistics, Harvard University, Science Center 715, 1 Oxford Street, Cambridge, MA 02138, USA', 'institution_ids': ['https://openalex.org/I24943067', 'https://openalex.org/I136199984', 'https://openalex.org/I116953780', 'https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045575546', 'display_name': 'X. Shirley Liu', 'orcid': 'https://orcid.org/0000-0003-4736-7339'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'X. Shirley Liu', 'raw_affiliation_strings': ['1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 20092, China, 2Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, 220 Handan Road, Shanghai, 200433, China, 3Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Harvard University and 4Department of Statistics, Harvard University, Science Center 715, 1 Oxford Street, Cambridge, MA 02138, USA'], 'affiliations': [{'raw_affiliation_string': '1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 20092, China, 2Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, 220 Handan Road, Shanghai, 200433, China, 3Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Harvard University and 4Department of Statistics, Harvard University, Science Center 715, 1 Oxford Street, Cambridge, MA 02138, USA', 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I116953780', 'https://openalex.org/I4210117453', 'https://openalex.org/I24943067']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5007650371', 'display_name': 'Yong Zhang', 'orcid': 'https://orcid.org/0000-0001-6316-2734'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I24943067', 'display_name': 'Fudan University', 'ror': 'https://ror.org/013q1eq08', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24943067']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Yong Zhang', 'raw_affiliation_strings': ['1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 20092, China, 2Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, 220 Handan Road, Shanghai, 200433, China, 3Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Harvard University and 4Department of Statistics, Harvard University, Science Center 715, 1 Oxford Street, Cambridge, MA 02138, USA'], 'affiliations': [{'raw_affiliation_string': '1 Department of Bioinformatics, School of Life sciences and Technology, Tongji University, 1239 Siping Road, Shanghai 20092, China, 2Shanghai Key Laboratory of Intelligent Information Processing, Fudan University, 220 Handan Road, Shanghai, 200433, China, 3Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Harvard University and 4Department of Statistics, Harvard University, Science Center 715, 1 Oxford Street, Cambridge, MA 02138, USA', 'institution_ids': ['https://openalex.org/I136199984', 'https://openalex.org/I116953780', 'https://openalex.org/I4210117453', 'https://openalex.org/I24943067']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3618, 'currency': 'USD', 'value_usd': 3618, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 7.716, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 396, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '28', 'issue': '21', 'first_page': '2782', 'last_page': '2788'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10015', 'display_name': 'RNA Sequencing Data Analysis', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Role of Long Noncoding RNAs in Cancer and Development', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/replicate', 'display_name': 'Replicate', 'score': 0.810162}, {'id': 'https://openalex.org/keywords/fold-change', 'display_name': 'Fold change', 'score': 0.63368964}, {'id': 'https://openalex.org/keywords/gene-expression-regulation', 'display_name': 'Gene Expression Regulation', 'score': 0.593895}, {'id': 'https://openalex.org/keywords/genome-annotation', 'display_name': 'genome annotation', 'score': 0.542037}, {'id': 'https://openalex.org/keywords/rna-seq', 'display_name': 'RNA-Seq', 'score': 0.516472}, {'id': 'https://openalex.org/keywords/mrna-modification', 'display_name': 'mRNA modification', 'score': 0.51483}, {'id': 'https://openalex.org/keywords/sequence-alignment', 'display_name': 'sequence alignment', 'score': 0.514223}], 'concepts': [{'id': 'https://openalex.org/C2781162219', 'wikidata': 'https://www.wikidata.org/wiki/Q26250693', 'display_name': 'Replicate', 'level': 2, 'score': 0.810162}, {'id': 'https://openalex.org/C107397762', 'wikidata': 'https://www.wikidata.org/wiki/Q2542347', 'display_name': 'RNA-Seq', 'level': 5, 'score': 0.7948681}, {'id': 'https://openalex.org/C2779018089', 'wikidata': 'https://www.wikidata.org/wiki/Q17014303', 'display_name': 'Fold change', 'level': 4, 'score': 0.63368964}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.62483895}, {'id': 'https://openalex.org/C162317418', 'wikidata': 'https://www.wikidata.org/wiki/Q252857', 'display_name': 'Transcriptome', 'level': 4, 'score': 0.5843163}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5336761}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.5143703}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.49485964}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.48572332}, {'id': 'https://openalex.org/C189430467', 'wikidata': 'https://www.wikidata.org/wiki/Q7293293', 'display_name': 'Ranking (information retrieval)', 'level': 2, 'score': 0.42846835}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.32421598}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.3105647}, {'id': 'https://openalex.org/C154945302', 'wikidata': 'https://www.wikidata.org/wiki/Q11660', 'display_name': 'Artificial intelligence', 'level': 1, 'score': 0.10599315}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.105284184}, {'id': 'https://openalex.org/C105795698', 'wikidata': 'https://www.wikidata.org/wiki/Q12483', 'display_name': 'Statistics', 'level': 1, 'score': 0.09640333}], 'mesh': [{'descriptor_ui': 'D000465', 'descriptor_name': 'Algorithms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D030541', 'descriptor_name': 'Databases, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D017423', 'descriptor_name': 'Sequence Analysis, RNA', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017423', 'descriptor_name': 'Sequence Analysis, RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017423', 'descriptor_name': 'Sequence Analysis, RNA', 'qualifier_ui': 'Q000191', 'qualifier_name': 'economics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/bioinformatics/bts515', 'pdf_url': 'https://academic.oup.com/bioinformatics/article-pdf/28/21/2782/48875974/bioinformatics_28_21_2782.pdf', 'source': {'id': 'https://openalex.org/S52395412', 'display_name': 'Bioinformatics', 'issn_l': '1367-4803', 'issn': ['1367-4803', '1367-4811'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22923299', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/bioinformatics/bts515', 'pdf_url': 'https://academic.oup.com/bioinformatics/article-pdf/28/21/2782/48875974/bioinformatics_28_21_2782.pdf', 'source': {'id': 'https://openalex.org/S52395412', 'display_name': 'Bioinformatics', 'issn_l': '1367-4803', 'issn': ['1367-4803', '1367-4811'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1948145985', 'https://openalex.org/W1981509058', 'https://openalex.org/W1984708728', 'https://openalex.org/W1989367702', 'https://openalex.org/W1992133876', 'https://openalex.org/W1992550017', 'https://openalex.org/W2015553373', 'https://openalex.org/W2042372709', 'https://openalex.org/W2047765648', 'https://openalex.org/W2067151470', 'https://openalex.org/W2070929669', 'https://openalex.org/W2071837646', 'https://openalex.org/W2072349313', 'https://openalex.org/W2075610412', 'https://openalex.org/W2094678200', 'https://openalex.org/W2100448568', 'https://openalex.org/W2101042581', 'https://openalex.org/W2102304447', 'https://openalex.org/W2105776281', 'https://openalex.org/W2107060225', 'https://openalex.org/W2114104545', 'https://openalex.org/W2117089877', 'https://openalex.org/W2118532317', 'https://openalex.org/W2119034410', 'https://openalex.org/W2121211805', 'https://openalex.org/W2122683221', 'https://openalex.org/W2128016314', 'https://openalex.org/W2130410032', 'https://openalex.org/W2133166282', 'https://openalex.org/W2133210805', 'https://openalex.org/W2137839234', 'https://openalex.org/W2141458291', 'https://openalex.org/W2144141220', 'https://openalex.org/W2146614932', 'https://openalex.org/W2151081606', 'https://openalex.org/W2152239989', 'https://openalex.org/W2154431984', 'https://openalex.org/W2156631105', 'https://openalex.org/W2164216268'], 'related_works': ['https://openalex.org/W4377231761', 'https://openalex.org/W4362530199', 'https://openalex.org/W4362512073', 'https://openalex.org/W4362511917', 'https://openalex.org/W4362511560', 'https://openalex.org/W4362485908', 'https://openalex.org/W4285162488', 'https://openalex.org/W2904597490', 'https://openalex.org/W2268123450', 'https://openalex.org/W2093288248'], 'abstract_inverted_index': {'Abstract': [0], 'Motivation:': [1], 'RNA-seq': [2, 28, 43, 49, 99, 132], 'has': [3], 'been': [4], 'widely': [5], 'used': [6], 'in': [7, 30, 51], 'transcriptome': [8], 'analysis': [9, 133], 'to': [10, 89], 'effectively': [11], 'measure': [12], 'gene': [13, 32, 142], 'expression': [14, 33, 106], 'levels.': [15], 'Although': [16], 'sequencing': [17], 'costs': [18], 'are': [19, 170], 'rapidly': [20], 'decreasing,': [21], 'almost': [22], '70%': [23], 'of': [24, 57, 94, 113, 124], 'all': [25], 'the': [26, 31, 54, 83, 110, 122], 'human': [27], 'samples': [29], 'omnibus': [34], 'do': [35], 'not': [36], 'have': [37], 'biological': [38, 76, 140, 148], 'replicates': [39], 'and': [40, 126, 135, 139], 'more': [41, 137], 'unreplicated': [42], 'data': [44, 50, 169], 'were': [45], 'published': [46], 'than': [47], 'replicated': [48], '2011.': [52], 'Despite': [53], 'large': [55], 'amount': [56], 'single': [58, 75, 147], 'replicate': [59, 77, 149], 'studies,': [60], 'there': [61], 'is': [62, 78, 150, 158], 'currently': [63], 'no': [64], 'satisfactory': [65], 'method': [66], 'for': [67, 105], 'detecting': [68], 'differentially': [69, 95], 'expressed': [70, 96], 'genes': [71, 97], 'when': [72, 144], 'only': [73, 145], 'a': [74, 146], 'available.': [79, 151], 'Results:': [80], 'We': [81], 'present': [82], 'GFOLD': [84, 101, 120], '(generalized': [85], 'fold': [86, 115, 127], 'change)': [87], 'algorithm': [88], 'produce': [90], 'biologically': [91], 'meaningful': [92, 141], 'rankings': [93, 143], 'from': [98], 'data.': [100], 'assigns': [102], 'reliable': [103], 'statistics': [104], 'changes': [107], 'based': [108], 'on': [109], 'posterior': [111], 'distribution': [112], 'log': [114], 'change.': [116], 'In': [117], 'this': [118], 'way,': [119], 'overcomes': [121], 'shortcomings': [123], 'P-value': [125], 'change': [128], 'calculated': [129], 'by': [130], 'existing': [131], 'methods': [134], 'gives': [136], 'stable': [138], 'Availability:': [152], 'The': [153], 'open': [154], 'source': [155], 'C/C++': [156], 'program': [157], 'available': [159, 171], 'at': [160, 172], 'http://www.tongji.edu.cn/∼zhanglab/GFOLD/index.html': [161], 'Contact:': [162], '[email protected]': [163], 'or': [164], '[email protected]': [165], 'Supplementary': [166, 168], 'information:': [167], 'Bioinformatics': [173], 'online.': [174]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2155839154', 'counts_by_year': [{'year': 2024, 'cited_by_count': 25}, {'year': 2023, 'cited_by_count': 32}, {'year': 2022, 'cited_by_count': 30}, {'year': 2021, 'cited_by_count': 48}, {'year': 2020, 'cited_by_count': 49}, {'year': 2019, 'cited_by_count': 35}, {'year': 2018, 'cited_by_count': 45}, {'year': 2017, 'cited_by_count': 31}, {'year': 2016, 'cited_by_count': 41}, {'year': 2015, 'cited_by_count': 29}, {'year': 2014, 'cited_by_count': 18}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-13T22:56:32.564329', 'created_date': '2016-06-24'}