Publication Information

{'id': 'https://openalex.org/W2155669068', 'doi': 'https://doi.org/10.1093/genetics/96.2.435', 'title': 'ISOLATION AND GENETIC CHARACTERIZATION OF CELL-LINEAGE MUTANTS OF THE NEMATODE <i>CAENORHABDITIS ELEGANS</i>', 'display_name': 'ISOLATION AND GENETIC CHARACTERIZATION OF CELL-LINEAGE MUTANTS OF THE NEMATODE <i>CAENORHABDITIS ELEGANS</i>', 'publication_year': 1980, 'publication_date': '1980-10-01', 'ids': {'openalex': 'https://openalex.org/W2155669068', 'doi': 'https://doi.org/10.1093/genetics/96.2.435', 'mag': '2155669068', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7262539', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1214309'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/genetics/96.2.435', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S65932378', 'display_name': 'Genetics', 'issn_l': '0016-6731', 'issn': ['0016-6731', '1943-2631'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1214309', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075093223', 'display_name': 'H. Robert Horvitz', 'orcid': 'https://orcid.org/0000-0002-9964-9613'}, 'institutions': [{'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'H Robert Horvitz', 'raw_affiliation_strings': ['Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139', 'institution_ids': ['https://openalex.org/I63966007']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5018043809', 'display_name': 'John Sulston', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170203145', 'display_name': 'MRC Laboratory of Molecular Biology', 'ror': 'https://ror.org/00tw3jy02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I170203145', 'https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'John E Sulston', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, England'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, England', 'institution_ids': ['https://openalex.org/I170203145']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4264, 'currency': 'USD', 'value_usd': 4264, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.223, 'has_fulltext': False, 'cited_by_count': 413, 'citation_normalized_percentile': {'value': 0.985612, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '96', 'issue': '2', 'first_page': '435', 'last_page': '454'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10676', 'display_name': 'Genetics, Aging, and Longevity in Model Organisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1302', 'display_name': 'Aging'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10676', 'display_name': 'Genetics, Aging, and Longevity in Model Organisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1302', 'display_name': 'Aging'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12005', 'display_name': 'Spaceflight effects on biology', 'score': 0.945, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/caenorhabditis', 'display_name': 'Caenorhabditis', 'score': 0.6178671}, {'id': 'https://openalex.org/keywords/lineage', 'display_name': 'Lineage (genetic)', 'score': 0.551557}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.9237217}, {'id': 'https://openalex.org/C188082640', 'wikidata': 'https://www.wikidata.org/wiki/Q1780899', 'display_name': 'Complementation', 'level': 4, 'score': 0.8340474}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.82547283}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.8192073}, {'id': 'https://openalex.org/C2778944004', 'wikidata': 'https://www.wikidata.org/wiki/Q91703', 'display_name': 'Caenorhabditis elegans', 'level': 3, 'score': 0.70810574}, {'id': 'https://openalex.org/C2776496032', 'wikidata': 'https://www.wikidata.org/wiki/Q1904768', 'display_name': 'Caenorhabditis', 'level': 4, 'score': 0.6178671}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.6044988}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.5625485}, {'id': 'https://openalex.org/C2776817793', 'wikidata': 'https://www.wikidata.org/wiki/Q6553369', 'display_name': 'Lineage (genetic)', 'level': 3, 'score': 0.551557}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.5347914}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.53469104}], 'mesh': [{'descriptor_ui': 'D002107', 'descriptor_name': 'Caenorhabditis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005855', 'descriptor_name': 'Germ Layers', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002107', 'descriptor_name': 'Caenorhabditis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003433', 'descriptor_name': 'Crosses, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005808', 'descriptor_name': 'Genes, Recessive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005855', 'descriptor_name': 'Germ Layers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/genetics/96.2.435', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S65932378', 'display_name': 'Genetics', 'issn_l': '0016-6731', 'issn': ['0016-6731', '1943-2631'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1214309', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7262539', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1214309', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 12, 'referenced_works': ['https://openalex.org/W1557991403', 'https://openalex.org/W1944127002', 'https://openalex.org/W1948560580', 'https://openalex.org/W1966433657', 'https://openalex.org/W1984944970', 'https://openalex.org/W1986006829', 'https://openalex.org/W2003154381', 'https://openalex.org/W2044810100', 'https://openalex.org/W2053753856', 'https://openalex.org/W2069575907', 'https://openalex.org/W2096285464', 'https://openalex.org/W2106949927'], 'related_works': ['https://openalex.org/W4385516583', 'https://openalex.org/W4313474347', 'https://openalex.org/W4286855404', 'https://openalex.org/W2345399109', 'https://openalex.org/W2276115873', 'https://openalex.org/W2145924285', 'https://openalex.org/W2111599449', 'https://openalex.org/W2047940407', 'https://openalex.org/W1987113372', 'https://openalex.org/W1967825628'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Twenty-four': [1], 'mutants': [2, 47, 72, 89, 117, 127], 'that': [3, 30, 40, 56, 63, 141], 'alter': [4], 'the': [5, 12, 50, 87, 97, 107, 126, 146], 'normally': [6, 43], 'invariant': [7], 'post-embryonic': [8], 'cell': [9, 27, 66, 99], 'lineages': [10, 67], 'of': [11, 24, 52, 84, 86, 102, 109, 125, 149], 'nematode': [13], 'Caenorhabditis': [14], 'elegans': [15], 'have': [16, 78], 'been': [17, 79], 'isolated': [18], 'and': [19], 'genetically': [20], 'characterized.': [21], 'In': [22], 'some': [23, 65], 'these': [25], 'mutants,': [26, 37], 'divisions': [28, 100], 'fail': [29], 'occur': [31], 'in': [32, 35, 49], 'wild-type': [33], 'animals;': [34], 'other': [36], 'cells': [38], 'divide': [39], 'do': [41, 44], 'not': [42, 69], 'so.': [45], 'The': [46, 81], 'differ': [48], 'specificities': [51], 'their': [53, 142], 'defects,': [54], 'so': [55], 'it': [57], 'is': [58], 'possible': [59], 'to': [60, 134], 'identify': [61], 'mutations': [62], 'affect': [64], 'but': [68], 'others.': [70], 'These': [71], 'define': [73], '14': [74], 'complementation': [75], 'groups,': [76], 'which': [77], 'mapped.': [80], 'abnormal': [82], 'phenotype': [83], 'most': [85], 'cell-lineage': [88, 116], 'results': [90], 'from': [91, 145], 'a': [92], 'single': [93], 'recessive': [94, 112], 'mutation;': [95], 'however,': [96], 'excessive': [98], 'characteristic': [101], 'one': [103], 'strain,': [104], 'CB1322,': [105], 'require': [106], 'presence': [108], 'two': [110], 'unlinked': [111], 'mutations.': [113], 'All': [114], '24': [115], 'display': [118], 'incomplete': [119], 'penetrance': [120], 'and/or': [121], 'variable': [122], 'expressivity.': [123], 'Three': [124], 'are': [128], 'suppressed': [129], 'by': [130], 'pleiotropic': [131], 'suppressors': [132], 'believed': [133], 'be': [135], 'specific': [136], 'for': [137], 'null': [138], 'alleles,': [139], 'suggesting': [140], 'phenotypes': [143], 'result': [144], 'complete': [147], 'absence': [148], 'gene': [150], 'activity.': [151]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2155669068', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 20}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 15}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2024-12-10T05:55:09.909419', 'created_date': '2016-06-24'}