Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2155230904', 'doi': 'https://doi.org/10.1016/j.bbamcr.2007.01.002', 'title': 'Regulation of MAPKs by growth factors and receptor tyrosine kinases', 'display_name': 'Regulation of MAPKs by growth factors and receptor tyrosine kinases', 'publication_year': 2007, 'publication_date': '2007-01-11', 'ids': {'openalex': 'https://openalex.org/W2155230904', 'doi': 'https://doi.org/10.1016/j.bbamcr.2007.01.002', 'mag': '2155230904', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17306385', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2758354'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbamcr.2007.01.002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210226410', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Molecular Cell Research', 'issn_l': '0167-4889', 'issn': ['0167-4889', '1879-2596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2758354?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103800467', 'display_name': 'Menachem Katz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Menachem Katz', 'raw_affiliation_strings': ['Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048280875', 'display_name': 'Ido Amit', 'orcid': 'https://orcid.org/0000-0003-2968-877X'}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Ido Amit', 'raw_affiliation_strings': ['Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5038055187', 'display_name': 'Yosef Yarden', 'orcid': 'https://orcid.org/0000-0003-4168-7884'}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': True, 'raw_author_name': 'Yosef Yarden', 'raw_affiliation_strings': ['Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5038055187'], 'corresponding_institution_ids': ['https://openalex.org/I53964585'], 'apc_list': {'value': 3380, 'currency': 'USD', 'value_usd': 3380, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.538, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 438, 'citation_normalized_percentile': {'value': 0.999686, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '1773', 'issue': '8', 'first_page': '1161', 'last_page': '1176'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11533', 'display_name': 'Mammalian MAP Kinase Signaling Pathways', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11533', 'display_name': 'Mammalian MAP Kinase Signaling Pathways', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'mTOR Signaling in Growth and Disease', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/receptor-protein-tyrosine-kinases', 'display_name': 'Receptor Protein-Tyrosine Kinases', 'score': 0.53991246}, {'id': 'https://openalex.org/keywords/cell-growth', 'display_name': 'Cell Growth', 'score': 0.513274}], 'concepts': [{'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.81725353}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.8007048}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6647444}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.6304183}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.59440386}, {'id': 'https://openalex.org/C132149769', 'wikidata': 'https://www.wikidata.org/wiki/Q899651', 'display_name': 'Mitogen-activated protein kinase', 'level': 3, 'score': 0.5454569}, {'id': 'https://openalex.org/C2911166042', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor Protein-Tyrosine Kinases', 'level': 4, 'score': 0.53991246}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.53378266}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.5091707}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4419176}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.43012983}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32139885}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19462645}], 'mesh': [{'descriptor_ui': 'D006133', 'descriptor_name': 'Growth Substances', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004705', 'descriptor_name': 'Endocytosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005246', 'descriptor_name': 'Feedback', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006133', 'descriptor_name': 'Growth Substances', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D009857', 'descriptor_name': 'Oncogenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020239', 'descriptor_name': 'Receptor Cross-Talk', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbamcr.2007.01.002', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210226410', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Molecular Cell Research', 'issn_l': '0167-4889', 'issn': ['0167-4889', '1879-2596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2758354', 'pdf_url': 'https://europepmc.org/articles/pmc2758354?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758354', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17306385', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2758354', 'pdf_url': 'https://europepmc.org/articles/pmc2758354?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 196, 'referenced_works': ['https://openalex.org/W1525183361', 'https://openalex.org/W1550092936', 'https://openalex.org/W1571287379', 'https://openalex.org/W1572526443', 'https://openalex.org/W1578523240', 'https://openalex.org/W1584155261', 'https://openalex.org/W1585517331', 'https://openalex.org/W1585913386', 'https://openalex.org/W1589959819', 'https://openalex.org/W1599518523', 'https://openalex.org/W1605302012', 'https://openalex.org/W1619161113', 'https://openalex.org/W1639582946', 'https://openalex.org/W1666849257', 'https://openalex.org/W1667204010', 'https://openalex.org/W1765059066', 'https://openalex.org/W1774418672', 'https://openalex.org/W1821858011', 'https://openalex.org/W1928260425', 'https://openalex.org/W1958742527', 'https://openalex.org/W1964321121', 'https://openalex.org/W1966453709', 'https://openalex.org/W1966658428', 'https://openalex.org/W1967265143', 'https://openalex.org/W1968275604', 'https://openalex.org/W1969785844', 'https://openalex.org/W1972607682', 'https://openalex.org/W1973021296', 'https://openalex.org/W1973071934', 'https://openalex.org/W1975646272', 'https://openalex.org/W1976385326', 'https://openalex.org/W1977926787', 'https://openalex.org/W1978760124', 'https://openalex.org/W1979109241', 'https://openalex.org/W1983523339', 'https://openalex.org/W1983536745', 'https://openalex.org/W1984536659', 'https://openalex.org/W1984587167', 'https://openalex.org/W1985035689', 'https://openalex.org/W1987427290', 'https://openalex.org/W1989480480', 'https://openalex.org/W1990669035', 'https://openalex.org/W1991321737', 'https://openalex.org/W1991738330', 'https://openalex.org/W1992945955', 'https://openalex.org/W1993338076', 'https://openalex.org/W1995242599', 'https://openalex.org/W1995499011', 'https://openalex.org/W1995685525', 'https://openalex.org/W1995819749', 'https://openalex.org/W1995894679', 'https://openalex.org/W2001234795', 'https://openalex.org/W2001521752', 'https://openalex.org/W2001895687', 'https://openalex.org/W2002215628', 'https://openalex.org/W2006254842', 'https://openalex.org/W2006282831', 'https://openalex.org/W2009707997', 'https://openalex.org/W2010968880', 'https://openalex.org/W2011381918', 'https://openalex.org/W2012448969', 'https://openalex.org/W2012686576', 'https://openalex.org/W2012987137', 'https://openalex.org/W2014053430', 'https://openalex.org/W2017256678', 'https://openalex.org/W2018896819', 'https://openalex.org/W2019172009', 'https://openalex.org/W2020042259', 'https://openalex.org/W2020099509', 'https://openalex.org/W2020525682', 'https://openalex.org/W2020600496', 'https://openalex.org/W2022840517', 'https://openalex.org/W2023550672', 'https://openalex.org/W2024985960', 'https://openalex.org/W2026055716', 'https://openalex.org/W2028412132', 'https://openalex.org/W2029146318', 'https://openalex.org/W2031390067', 'https://openalex.org/W2031626005', 'https://openalex.org/W2035912195', 'https://openalex.org/W2036312188', 'https://openalex.org/W2037792829', 'https://openalex.org/W2038309899', 'https://openalex.org/W2038447145', 'https://openalex.org/W2040196938', 'https://openalex.org/W2040620685', 'https://openalex.org/W2043696829', 'https://openalex.org/W2045714098', 'https://openalex.org/W2047330178', 'https://openalex.org/W2047365291', 'https://openalex.org/W2049274590', 'https://openalex.org/W2049336663', 'https://openalex.org/W2049759529', 'https://openalex.org/W2050085005', 'https://openalex.org/W2051120695', 'https://openalex.org/W2055181868', 'https://openalex.org/W2055519466', 'https://openalex.org/W2056563854', 'https://openalex.org/W2056683808', 'https://openalex.org/W2057126981', 'https://openalex.org/W2058620780', 'https://openalex.org/W2059633680', 'https://openalex.org/W2061013276', 'https://openalex.org/W2061701210', 'https://openalex.org/W2061744300', 'https://openalex.org/W2062821569', 'https://openalex.org/W2063220206', 'https://openalex.org/W2064129448', 'https://openalex.org/W2066139399', 'https://openalex.org/W2066655424', 'https://openalex.org/W2066991902', 'https://openalex.org/W2068089675', 'https://openalex.org/W2070204715', 'https://openalex.org/W2072061824', 'https://openalex.org/W2074089133', 'https://openalex.org/W2074306827', 'https://openalex.org/W2074915514', 'https://openalex.org/W2075261741', 'https://openalex.org/W2076485183', 'https://openalex.org/W2077492124', 'https://openalex.org/W2079494240', 'https://openalex.org/W2079712059', 'https://openalex.org/W2080628130', 'https://openalex.org/W2080686146', 'https://openalex.org/W2080719056', 'https://openalex.org/W2081599782', 'https://openalex.org/W2084734831', 'https://openalex.org/W2086783008', 'https://openalex.org/W2087073346', 'https://openalex.org/W2087963453', 'https://openalex.org/W2089548010', 'https://openalex.org/W2093226717', 'https://openalex.org/W2094772268', 'https://openalex.org/W2095152292', 'https://openalex.org/W2095687384', 'https://openalex.org/W2098173166', 'https://openalex.org/W2099536948', 'https://openalex.org/W2100794900', 'https://openalex.org/W2102606027', 'https://openalex.org/W2102646127', 'https://openalex.org/W2103174300', 'https://openalex.org/W2104337193', 'https://openalex.org/W2106000067', 'https://openalex.org/W2114072364', 'https://openalex.org/W2114840684', 'https://openalex.org/W2118375252', 'https://openalex.org/W2120026123', 'https://openalex.org/W2121170253', 'https://openalex.org/W2122057254', 'https://openalex.org/W2122381944', 'https://openalex.org/W2122536100', 'https://openalex.org/W2123995229', 'https://openalex.org/W2124102897', 'https://openalex.org/W2124662474', 'https://openalex.org/W2125547572', 'https://openalex.org/W2125589729', 'https://openalex.org/W2126726971', 'https://openalex.org/W2127150495', 'https://openalex.org/W2128245496', 'https://openalex.org/W2129755293', 'https://openalex.org/W2130084958', 'https://openalex.org/W2130561652', 'https://openalex.org/W2132148332', 'https://openalex.org/W2132578558', 'https://openalex.org/W2133346949', 'https://openalex.org/W2136222819', 'https://openalex.org/W2136390065', 'https://openalex.org/W2138231208', 'https://openalex.org/W2138747143', 'https://openalex.org/W2139524845', 'https://openalex.org/W2141715168', 'https://openalex.org/W2142242441', 'https://openalex.org/W2142631293', 'https://openalex.org/W2143518750', 'https://openalex.org/W2143891754', 'https://openalex.org/W2145285946', 'https://openalex.org/W2145460819', 'https://openalex.org/W2145950214', 'https://openalex.org/W2153032235', 'https://openalex.org/W2159542715', 'https://openalex.org/W2160105055', 'https://openalex.org/W2161821474', 'https://openalex.org/W2163188200', 'https://openalex.org/W2163825667', 'https://openalex.org/W2164053051', 'https://openalex.org/W2165169147', 'https://openalex.org/W2170205898', 'https://openalex.org/W2171529739', 'https://openalex.org/W2171859557', 'https://openalex.org/W2187743525', 'https://openalex.org/W2296679604', 'https://openalex.org/W2337262864', 'https://openalex.org/W4211017114', 'https://openalex.org/W45648581', 'https://openalex.org/W4903968', 'https://openalex.org/W74885494'], 'related_works': ['https://openalex.org/W284991352', 'https://openalex.org/W2321063763', 'https://openalex.org/W2198509606', 'https://openalex.org/W2126073113', 'https://openalex.org/W2088346679', 'https://openalex.org/W2086259825', 'https://openalex.org/W2075091575', 'https://openalex.org/W2071513467', 'https://openalex.org/W2061697147', 'https://openalex.org/W1991624054'], 'abstract_inverted_index': {'Multiple': [0], 'growth-': [1], 'and': [2, 8, 39, 42, 61, 68, 97, 118], 'differentiation-inducing': [3], 'polypeptide': [4], 'factors': [5], 'bind': [6], 'to': [7, 15, 46, 50, 94, 112, 119, 135], 'activate': [9], 'transmembrane': [10], 'receptors': [11], 'tyrosine': [12], 'kinases': [13], '(RTKs),': [14], 'instigate': [16], 'a': [17, 83], 'plethora': [18], 'of': [19, 25, 55, 76, 85, 92, 105, 115, 131], 'biochemical': [20], 'cascades': [21], 'culminating': [22], 'in': [23], 'regulation': [24], 'cell': [26], 'fate.': [27], 'We': [28, 87], 'concentrate': [29], 'on': [30, 126], 'the': [31, 71, 79, 89, 127], 'four': [32], 'linear': [33], 'mitogen-activated': [34], 'protein': [35], 'kinase': [36], '(MAPK)': [37], 'cascades,': [38], 'highlight': [40], 'organizational': [41], 'functional': [43], 'features': [44], 'relevant': [45], 'their': [47], 'action': [48], 'downstream': [49, 134], 'RTKs.': [51, 137], 'Two': [52], 'cellular': [53], 'outcomes': [54], 'growth': [56], 'factor': [57], 'action,': [58], 'namely': [59], 'proliferation': [60], 'migration,': [62], 'are': [63], 'critically': [64], 'regulated': [65], 'by': [66], 'MAPKs': [67, 93, 132], 'we': [69], 'detail': [70], 'underlying': [72], 'molecular': [73], 'mechanisms.': [74], 'Hyperactivation': [75], 'MAPKs,': [77], 'primarily': [78], 'Erk': [80], 'pathway,': [81], 'is': [82], 'landmark': [84], 'cancer.': [86], 'describe': [88], 'many': [90], 'links': [91], 'tumor': [95], 'biology': [96], 'review': [98], 'studies': [99], 'that': [100], 'identified': [101], 'machineries': [102], 'permitting': [103], 'prolongation': [104], 'MAPK': [106, 116], 'signaling.': [107], 'Models': [108], 'attributing': [109], 'signal': [110], 'integration': [111], 'both': [113], 'phosphorylation': [114], 'substrates': [117], 'MAPK-regulated': [120], 'gene': [121], 'expression': [122], 'may': [123], 'shed': [124], 'light': [125], 'remarkably': [128], 'diversified': [129], 'functions': [130], 'acting': [133], 'activated': [136]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2155230904', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 27}, {'year': 2021, 'cited_by_count': 29}, {'year': 2020, 'cited_by_count': 31}, {'year': 2019, 'cited_by_count': 32}, {'year': 2018, 'cited_by_count': 43}, {'year': 2017, 'cited_by_count': 34}, {'year': 2016, 'cited_by_count': 23}, {'year': 2015, 'cited_by_count': 19}, {'year': 2014, 'cited_by_count': 30}, {'year': 2013, 'cited_by_count': 17}, {'year': 2012, 'cited_by_count': 17}], 'updated_date': '2024-09-17T16:44:36.804537', 'created_date': '2016-06-24'}