Publication Information

{'id': 'https://openalex.org/W2154929943', 'doi': 'https://doi.org/10.1172/jci105503', 'title': 'Human Placental Lactogen: Studies of Its Acute Metabolic Effects and Disposition in Normal Man*', 'display_name': 'Human Placental Lactogen: Studies of Its Acute Metabolic Effects and Disposition in Normal Man*', 'publication_year': 1967, 'publication_date': '1967-01-01', 'ids': {'openalex': 'https://openalex.org/W2154929943', 'doi': 'https://doi.org/10.1172/jci105503', 'mag': '2154929943', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6018742', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/297025'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci105503', 'pdf_url': 'http://www.jci.org/articles/view/105503/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/105503/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5050073268', 'display_name': 'Paul A Beck', 'orcid': 'https://orcid.org/0000-0001-6494-9563'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}, {'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul Beck', 'raw_affiliation_strings': ['(From the Division of Metabolism, Department of Medicine, Washington University School of Medicine, St. Louis, Mo.)', 'Dept. of Medicine, Washington University School of Medicine, St. Louis, Mo. 63110.', 'Uni-versity of Colorado School of Medicine, Denver, Colo.'], 'affiliations': [{'raw_affiliation_string': '(From the Division of Metabolism, Department of Medicine, Washington University School of Medicine, St. Louis, Mo.)', 'institution_ids': ['https://openalex.org/I204465549']}, {'raw_affiliation_string': 'Uni-versity of Colorado School of Medicine, Denver, Colo.', 'institution_ids': ['https://openalex.org/I921990950']}, {'raw_affiliation_string': 'Dept. of Medicine, Washington University School of Medicine, St. Louis, Mo. 63110.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5008131820', 'display_name': 'William H. Daughaday', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}, {'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William H. Daughaday', 'raw_affiliation_strings': ['(From the Division of Metabolism, Department of Medicine, Washington University School of Medicine, St. Louis, Mo.)', 'Dept. of Medicine, Washington University School of Medicine, St. Louis, Mo. 63110.', 'Uni-versity of Colorado School of Medicine, Denver, Colo.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Medicine, Washington University School of Medicine, St. Louis, Mo. 63110.', 'institution_ids': ['https://openalex.org/I204465549']}, {'raw_affiliation_string': '(From the Division of Metabolism, Department of Medicine, Washington University School of Medicine, St. Louis, Mo.)', 'institution_ids': ['https://openalex.org/I204465549']}, {'raw_affiliation_string': 'Uni-versity of Colorado School of Medicine, Denver, Colo.', 'institution_ids': ['https://openalex.org/I921990950']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 12.28, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 198, 'citation_normalized_percentile': {'value': 0.994524, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '46', 'issue': '1', 'first_page': '103', 'last_page': '110'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11294', 'display_name': 'Infant Nutrition and Health', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11294', 'display_name': 'Infant Nutrition and Health', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13199', 'display_name': 'Digestive system and related health', 'score': 0.9674, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11629', 'display_name': 'Birth, Development, and Health', 'score': 0.9414, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/human-placental-lactogen', 'display_name': 'Human placental lactogen', 'score': 0.78299904}, {'id': 'https://openalex.org/keywords/disposition', 'display_name': 'Disposition', 'score': 0.6111572}, {'id': 'https://openalex.org/keywords/placental-lactogen', 'display_name': 'Placental lactogen', 'score': 0.5612958}, {'id': 'https://openalex.org/keywords/metabolic-clearance-rate', 'display_name': 'Metabolic clearance rate', 'score': 0.43050647}], 'concepts': [{'id': 'https://openalex.org/C2777675195', 'wikidata': 'https://www.wikidata.org/wiki/Q21154415', 'display_name': 'Human placental lactogen', 'level': 5, 'score': 0.78299904}, {'id': 'https://openalex.org/C38022665', 'wikidata': 'https://www.wikidata.org/wiki/Q1149305', 'display_name': 'Disposition', 'level': 2, 'score': 0.6111572}, {'id': 'https://openalex.org/C2777064457', 'wikidata': 'https://www.wikidata.org/wiki/Q1960869', 'display_name': 'Placental lactogen', 'level': 5, 'score': 0.5612958}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.55156547}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5088775}, {'id': 'https://openalex.org/C2909957684', 'wikidata': 'https://www.wikidata.org/wiki/Q1163287', 'display_name': 'Metabolic clearance rate', 'level': 3, 'score': 0.43050647}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41127133}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37419045}, {'id': 'https://openalex.org/C42407357', 'wikidata': 'https://www.wikidata.org/wiki/Q521', 'display_name': 'Physiology', 'level': 1, 'score': 0.32088095}, {'id': 'https://openalex.org/C2779234561', 'wikidata': 'https://www.wikidata.org/wiki/Q11995', 'display_name': 'Pregnancy', 'level': 2, 'score': 0.2781896}, {'id': 'https://openalex.org/C2776953305', 'wikidata': 'https://www.wikidata.org/wiki/Q1212935', 'display_name': 'Placenta', 'level': 4, 'score': 0.24259603}, {'id': 'https://openalex.org/C172680121', 'wikidata': 'https://www.wikidata.org/wiki/Q26513', 'display_name': 'Fetus', 'level': 3, 'score': 0.1330215}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.10654253}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.089221746}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C77805123', 'wikidata': 'https://www.wikidata.org/wiki/Q161272', 'display_name': 'Social psychology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D010926', 'descriptor_name': 'Placental Hormones', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D010926', 'descriptor_name': 'Placental Hormones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011388', 'descriptor_name': 'Prolactin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011388', 'descriptor_name': 'Prolactin', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D002241', 'descriptor_name': 'Carbohydrates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002241', 'descriptor_name': 'Carbohydrates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005227', 'descriptor_name': 'Fatty Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005227', 'descriptor_name': 'Fatty Acids', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005951', 'descriptor_name': 'Glucose Tolerance Test', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010926', 'descriptor_name': 'Placental Hormones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011388', 'descriptor_name': 'Prolactin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci105503', 'pdf_url': 'http://www.jci.org/articles/view/105503/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc297025', 'pdf_url': 'https://europepmc.org/articles/pmc297025?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC297025', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6018742', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci105503', 'pdf_url': 'http://www.jci.org/articles/view/105503/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/2', 'score': 0.46, 'display_name': 'Zero hunger'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1492153103', 'https://openalex.org/W1602265116', 'https://openalex.org/W174670461', 'https://openalex.org/W1951915438', 'https://openalex.org/W1965204208', 'https://openalex.org/W1979915515', 'https://openalex.org/W1984511403', 'https://openalex.org/W1988629329', 'https://openalex.org/W1991206813', 'https://openalex.org/W1995311633', 'https://openalex.org/W1997658013', 'https://openalex.org/W2000602480', 'https://openalex.org/W2002837243', 'https://openalex.org/W2009580551', 'https://openalex.org/W2036340454', 'https://openalex.org/W2039242258', 'https://openalex.org/W2043459412', 'https://openalex.org/W2046634524', 'https://openalex.org/W2053716155', 'https://openalex.org/W2058684239', 'https://openalex.org/W2065369627', 'https://openalex.org/W2068430810', 'https://openalex.org/W2080210534', 'https://openalex.org/W2083798037', 'https://openalex.org/W2095398597', 'https://openalex.org/W2098316604', 'https://openalex.org/W2103202925', 'https://openalex.org/W2103688560', 'https://openalex.org/W2124802960', 'https://openalex.org/W2141428265', 'https://openalex.org/W2188140043', 'https://openalex.org/W2321999068', 'https://openalex.org/W2323110212', 'https://openalex.org/W2409586042', 'https://openalex.org/W2410283669', 'https://openalex.org/W2413805152'], 'related_works': ['https://openalex.org/W2460682723', 'https://openalex.org/W2409264244', 'https://openalex.org/W2078498122', 'https://openalex.org/W2061755408', 'https://openalex.org/W2059770999', 'https://openalex.org/W2057402963', 'https://openalex.org/W2037316432', 'https://openalex.org/W2029217263', 'https://openalex.org/W2028372507', 'https://openalex.org/W165902369'], 'abstract_inverted_index': {'The': [0, 24], 'acute': [1], 'metabolic': [2, 28], 'effects': [3], 'and': [4, 17, 31], 'disposition': [5], 'of': [6, 34, 68, 74, 88], 'human': [7, 44], 'placental': [8], 'lactogen': [9], '(HPL)': [10], 'have': [11], 'been': [12], 'studied': [13], 'in': [14, 70, 86, 101, 112, 119], '15': [15], 'men': [16], '8': [18, 89], 'women': [19], 'during': [20, 128, 146], 'continuous': [21], 'intravenous': [22], 'infusions.': [23, 130], 'mean': [25], 'plasma': [26, 79, 104, 107, 123], 'half-life,': [27], 'pool': [29], 'size,': [30], 'turnover': [32], 'rate': [33], 'HPL': [35, 61, 69, 139], 'are': [36, 133], 'comparable': [37], 'to': [38, 82, 126, 144], 'the': [39, 49, 55, 136], 'values': [40], 'previously': [41], 'reported': [42], 'for': [43], 'growth': [45], 'hormone': [46], '(HGH).': [47], 'From': [48], 'data': [50], 'presented,': [51], 'we': [52], 'calculate': [53], 'that': [54, 138], 'placenta': [56], 'secretes': [57], 'approximately': [58], '290': [59], 'mg': [60], 'daily': [62], 'at': [63], 'term.': [64], 'After': [65], '12-hour': [66], 'infusions': [67], 'physiologic': [71, 142], 'amounts,': [72], 'impairment': [73], 'glucose': [75, 83, 116, 127], 'tolerance': [76, 121], 'despite': [77], 'increased': [78], 'insulin': [80, 124, 145], 'responses': [81, 125], 'was': [84], 'observed': [85], '7': [87], 'subjects': [90, 114], 'tested.': [91], 'However,': [92], 'HPL,': [93], 'unlike': [94], 'HGH,': [95], 'did': [96], 'not': [97], 'produce': [98], 'significant': [99], 'changes': [100], 'blood': [102], 'glucose,': [103], 'insulin,': [105], 'or': [106, 118, 122], 'free': [108], 'fatty': [109], 'acid': [110], 'concentrations': [111], 'fasting': [113], 'before': [115], 'administration': [117], 'carbohydrate': [120], '5-hour': [129], 'These': [131], 'findings': [132], 'compatible': [134], 'with': [135], 'thesis': [137], 'is': [140], 'a': [141], 'antagonist': [143], 'pregnancy.': [147]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2154929943', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2025-01-11T19:30:40.410647', 'created_date': '2016-06-24'}