Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2154108215', 'doi': 'https://doi.org/10.1083/jcb.200505079', 'title': 'A novel GTPase, CRAG, mediates promyelocytic leukemia protein–associated nuclear body formation and degradation of expanded polyglutamine protein', 'display_name': 'A novel GTPase, CRAG, mediates promyelocytic leukemia protein–associated nuclear body formation and degradation of expanded polyglutamine protein', 'publication_year': 2006, 'publication_date': '2006-02-06', 'ids': {'openalex': 'https://openalex.org/W2154108215', 'doi': 'https://doi.org/10.1083/jcb.200505079', 'mag': '2154108215', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16461359', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2063670'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200505079', 'pdf_url': 'https://rupress.org/jcb/article-pdf/172/4/497/1322847/497.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://rupress.org/jcb/article-pdf/172/4/497/1322847/497.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103147633', 'display_name': 'Qingyu Qin', 'orcid': 'https://orcid.org/0000-0003-1799-8586'}, 'institutions': [{'id': 'https://openalex.org/I65837984', 'display_name': 'Kobe University', 'ror': 'https://ror.org/03tgsfw79', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I65837984']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Qingyu Qin', 'raw_affiliation_strings': ['1Laboratory of Molecular Biochemistry', '2Division of Proteomics, Department of Genome Science, Graduate School of Medicine, Kobe University, Chuo-Ku, Kobe 650-0017, Japan'], 'affiliations': [{'raw_affiliation_string': '1Laboratory of Molecular Biochemistry', 'institution_ids': []}, {'raw_affiliation_string': '2Division of Proteomics, Department of Genome Science, Graduate School of Medicine, Kobe University, Chuo-Ku, Kobe 650-0017, Japan', 'institution_ids': ['https://openalex.org/I65837984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034333709', 'display_name': 'Ryoko Inatome', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I65837984', 'display_name': 'Kobe University', 'ror': 'https://ror.org/03tgsfw79', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I65837984']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ryoko Inatome', 'raw_affiliation_strings': ['1Laboratory of Molecular Biochemistry', '2Division of Proteomics, Department of Genome Science, Graduate School of Medicine, Kobe University, Chuo-Ku, Kobe 650-0017, Japan'], 'affiliations': [{'raw_affiliation_string': '1Laboratory of Molecular Biochemistry', 'institution_ids': []}, {'raw_affiliation_string': '2Division of Proteomics, Department of Genome Science, Graduate School of Medicine, Kobe University, Chuo-Ku, Kobe 650-0017, Japan', 'institution_ids': ['https://openalex.org/I65837984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030084862', 'display_name': 'Azusa Hotta', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I65837984', 'display_name': 'Kobe University', 'ror': 'https://ror.org/03tgsfw79', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I65837984']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Azusa Hotta', 'raw_affiliation_strings': ['1Laboratory of Molecular Biochemistry', '2Division of Proteomics, Department of Genome Science, Graduate School of Medicine, Kobe University, Chuo-Ku, Kobe 650-0017, Japan'], 'affiliations': [{'raw_affiliation_string': '2Division of Proteomics, Department of Genome Science, Graduate School of Medicine, Kobe University, Chuo-Ku, Kobe 650-0017, Japan', 'institution_ids': ['https://openalex.org/I65837984']}, {'raw_affiliation_string': '1Laboratory of Molecular Biochemistry', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055220053', 'display_name': 'Masaki Kojima', 'orcid': 'https://orcid.org/0009-0001-9190-4923'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Masaki Kojima', 'raw_affiliation_strings': ['1Laboratory of Molecular Biochemistry'], 'affiliations': [{'raw_affiliation_string': '1Laboratory of Molecular Biochemistry', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063421059', 'display_name': 'Hirohei Yamamura', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I65837984', 'display_name': 'Kobe University', 'ror': 'https://ror.org/03tgsfw79', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I65837984']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hirohei Yamamura', 'raw_affiliation_strings': ['2Division of Proteomics, Department of Genome Science, Graduate School of Medicine, Kobe University, Chuo-Ku, Kobe 650-0017, Japan'], 'affiliations': [{'raw_affiliation_string': '2Division of Proteomics, Department of Genome Science, Graduate School of Medicine, Kobe University, Chuo-Ku, Kobe 650-0017, Japan', 'institution_ids': ['https://openalex.org/I65837984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001341469', 'display_name': 'Hirokazu Hirai', 'orcid': 'https://orcid.org/0000-0002-0721-4293'}, 'institutions': [{'id': 'https://openalex.org/I10091056', 'display_name': 'Kanazawa University', 'ror': 'https://ror.org/02hwp6a56', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I10091056']}, {'id': 'https://openalex.org/I4210086780', 'display_name': 'Japan Science and Technology Agency', 'ror': 'https://ror.org/00097mb19', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210086780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hirokazu Hirai', 'raw_affiliation_strings': ['3Adavanced Science Research Center, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Japan', '4Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan'], 'affiliations': [{'raw_affiliation_string': '3Adavanced Science Research Center, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Japan', 'institution_ids': ['https://openalex.org/I10091056']}, {'raw_affiliation_string': '4Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan', 'institution_ids': ['https://openalex.org/I4210086780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018952929', 'display_name': 'Toshihiro Yoshizawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I146399215', 'display_name': 'University of Tsukuba', 'ror': 'https://ror.org/02956yf07', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146399215']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshihiro Yoshizawa', 'raw_affiliation_strings': ['5Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba 305-8575, Japan'], 'affiliations': [{'raw_affiliation_string': '5Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba 305-8575, Japan', 'institution_ids': ['https://openalex.org/I146399215']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051013835', 'display_name': 'Hirofumi Tanaka', 'orcid': 'https://orcid.org/0000-0002-1780-7471'}, 'institutions': [{'id': 'https://openalex.org/I149964584', 'display_name': 'Tokyo University of Pharmacy and Life Sciences', 'ror': 'https://ror.org/057jm7w82', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I149964584']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hirofumi Tanaka', 'raw_affiliation_strings': ['6Laboratory of Genome and Biosignal, School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan'], 'affiliations': [{'raw_affiliation_string': '6Laboratory of Genome and Biosignal, School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan', 'institution_ids': ['https://openalex.org/I149964584']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105409269', 'display_name': 'Kiyoko Fukami', 'orcid': 'https://orcid.org/0000-0003-3205-1542'}, 'institutions': [{'id': 'https://openalex.org/I149964584', 'display_name': 'Tokyo University of Pharmacy and Life Sciences', 'ror': 'https://ror.org/057jm7w82', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I149964584']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kiyoko Fukami', 'raw_affiliation_strings': ['6Laboratory of Genome and Biosignal, School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan'], 'affiliations': [{'raw_affiliation_string': '6Laboratory of Genome and Biosignal, School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan', 'institution_ids': ['https://openalex.org/I149964584']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5033672050', 'display_name': 'Shigeru Yanagi', 'orcid': 'https://orcid.org/0000-0002-1392-8663'}, 'institutions': [{'id': 'https://openalex.org/I4210086780', 'display_name': 'Japan Science and Technology Agency', 'ror': 'https://ror.org/00097mb19', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210086780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shigeru Yanagi', 'raw_affiliation_strings': ['1Laboratory of Molecular Biochemistry', '4Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan'], 'affiliations': [{'raw_affiliation_string': '4Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan', 'institution_ids': ['https://openalex.org/I4210086780']}, {'raw_affiliation_string': '1Laboratory of Molecular Biochemistry', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.368, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 48, 'citation_normalized_percentile': {'value': 0.916772, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '172', 'issue': '4', 'first_page': '497', 'last_page': '504'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10949', 'display_name': 'Genetic Neurodegenerative Diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10949', 'display_name': 'Genetic Neurodegenerative Diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11841', 'display_name': 'Nuclear Structure and Function', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nls', 'display_name': 'NLS', 'score': 0.5348441}, {'id': 'https://openalex.org/keywords/promyelocytic-leukemia-protein', 'display_name': 'Promyelocytic leukemia protein', 'score': 0.5214631}, {'id': 'https://openalex.org/keywords/importin', 'display_name': 'Importin', 'score': 0.4275657}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8093987}, {'id': 'https://openalex.org/C207332259', 'wikidata': 'https://www.wikidata.org/wiki/Q769143', 'display_name': 'GTPase', 'level': 2, 'score': 0.6126752}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.5917239}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.56626844}, {'id': 'https://openalex.org/C27740335', 'wikidata': 'https://www.wikidata.org/wiki/Q14878333', 'display_name': 'Proteasome', 'level': 2, 'score': 0.5421151}, {'id': 'https://openalex.org/C186435350', 'wikidata': 'https://www.wikidata.org/wiki/Q1050365', 'display_name': 'NLS', 'level': 4, 'score': 0.5348441}, {'id': 'https://openalex.org/C111441629', 'wikidata': 'https://www.wikidata.org/wiki/Q18030615', 'display_name': 'Promyelocytic leukemia protein', 'level': 5, 'score': 0.5214631}, {'id': 'https://openalex.org/C49805395', 'wikidata': 'https://www.wikidata.org/wiki/Q910966', 'display_name': 'Nuclear localization sequence', 'level': 3, 'score': 0.50281876}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.46078905}, {'id': 'https://openalex.org/C29512474', 'wikidata': 'https://www.wikidata.org/wiki/Q16860021', 'display_name': 'Nuclear protein', 'level': 4, 'score': 0.4423544}, {'id': 'https://openalex.org/C133882971', 'wikidata': 'https://www.wikidata.org/wiki/Q24205524', 'display_name': 'Importin', 'level': 5, 'score': 0.4275657}, {'id': 'https://openalex.org/C2780114586', 'wikidata': 'https://www.wikidata.org/wiki/Q40260', 'display_name': 'Cell nucleus', 'level': 3, 'score': 0.36951125}, {'id': 'https://openalex.org/C59157529', 'wikidata': 'https://www.wikidata.org/wiki/Q994741', 'display_name': 'Nuclear transport', 'level': 4, 'score': 0.35875118}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.32897076}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.25989294}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.23689064}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.08525768}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.0842213}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07840285}], 'mesh': [{'descriptor_ui': 'D020558', 'descriptor_name': 'GTP Phosphohydrolases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D045586', 'descriptor_name': 'Intranuclear Inclusion Bodies', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071193', 'descriptor_name': 'Autophagy-Related Protein 7', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071183', 'descriptor_name': 'Autophagy-Related Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020558', 'descriptor_name': 'GTP Phosphohydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020558', 'descriptor_name': 'GTP Phosphohydrolases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045586', 'descriptor_name': 'Intranuclear Inclusion Bodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019913', 'descriptor_name': 'Nuclear Localization Signals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019913', 'descriptor_name': 'Nuclear Localization Signals', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019913', 'descriptor_name': 'Nuclear Localization Signals', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071156', 'descriptor_name': 'Promyelocytic Leukemia Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D044764', 'descriptor_name': 'Ubiquitin-Activating Enzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044764', 'descriptor_name': 'Ubiquitin-Activating Enzymes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D044763', 'descriptor_name': 'Ubiquitin-Conjugating Enzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044763', 'descriptor_name': 'Ubiquitin-Conjugating Enzymes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014466', 'descriptor_name': 'Ultraviolet Rays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200505079', 'pdf_url': 'https://rupress.org/jcb/article-pdf/172/4/497/1322847/497.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2063670', 'pdf_url': 'https://europepmc.org/articles/pmc2063670?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063670', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16461359', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200505079', 'pdf_url': 'https://rupress.org/jcb/article-pdf/172/4/497/1322847/497.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Life on land', 'score': 0.43, 'id': 'https://metadata.un.org/sdg/15'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 18, 'referenced_works': ['https://openalex.org/W1986422550', 'https://openalex.org/W1993441783', 'https://openalex.org/W1998475589', 'https://openalex.org/W1998974178', 'https://openalex.org/W2007249806', 'https://openalex.org/W2015738018', 'https://openalex.org/W2021318983', 'https://openalex.org/W2039376206', 'https://openalex.org/W2051864256', 'https://openalex.org/W2055679500', 'https://openalex.org/W2056442786', 'https://openalex.org/W2089741493', 'https://openalex.org/W2109934071', 'https://openalex.org/W2114115164', 'https://openalex.org/W2134259857', 'https://openalex.org/W2146220883', 'https://openalex.org/W4256014245', 'https://openalex.org/W77858255'], 'related_works': ['https://openalex.org/W4320913516', 'https://openalex.org/W3122888278', 'https://openalex.org/W2574320882', 'https://openalex.org/W2353903672', 'https://openalex.org/W2143569646', 'https://openalex.org/W2081580769', 'https://openalex.org/W2053771737', 'https://openalex.org/W2040475713', 'https://openalex.org/W2005282433', 'https://openalex.org/W1975718215'], 'abstract_inverted_index': {'Polyglutamine': [0], 'diseases': [1, 5], 'are': [2], 'inherited': [3], 'neurodegenerative': [4], 'caused': [6], 'by': [7, 66, 100], 'the': [8, 70, 77, 81, 87, 95, 109, 139], 'expanded': [9], 'polyglutamine': [10, 142], 'proteins': [11], '(polyQs).': [12], 'We': [13, 119], 'have': [14], 'identified': [15], 'a': [16, 25, 58, 124], 'novel': [17], 'guanosine': [18], 'triphosphatase': [19], '(GTPase)': [20], 'named': [21], 'CRAG': [22, 42, 73, 85, 98, 122], 'that': [23, 121], 'contains': [24], 'nuclear': [26, 33, 78, 110], 'localization': [27], 'signal': [28], '(NLS)': [29], 'sequence': [30], 'and': [31, 45, 76, 114, 129, 134], 'forms': [32], 'inclusions': [34], 'in': [35, 57, 104, 131, 138], 'response': [36], 'to': [37], 'stress.': [38], 'After': [39], 'ultraviolet': [40], 'irradiation,': [41], 'interacted': [43], 'with': [44, 74], 'induced': [46], 'an': [47], 'enlarged': [48], 'ring-like': [49], 'structure': [50], 'of': [51, 72, 80, 89, 112, 126, 141], 'promyelocytic': [52], 'leukemia': [53], 'protein': [54], '(PML)': [55], 'body': [56], 'GTPase-dependent': [59], 'manner.': [60], 'Reactive': [61], 'oxygen': [62], 'species': [63], '(ROS)': [64], 'generated': [65], 'polyQ': [67, 75, 90, 113], 'accumulation': [68], 'triggered': [69], 'association': [71], 'translocation': [79, 111], 'CRAG–polyQ': [82], 'complex.': [83], 'Furthermore,': [84], 'promoted': [86], 'degradation': [88], 'at': [91], 'PML/CRAG': [92], 'bodies': [93], 'through': [94], 'ubiquitin–proteasome': [96], 'pathway.': [97], 'knockdown': [99], 'small': [101], 'interfering': [102], 'RNA': [103], 'neuronal': [105], 'cells': [106], 'consistently': [107], 'blocked': [108], 'enhanced': [115], 'polyQ-mediated': [116], 'cell': [117], 'death.': [118], 'propose': [120], 'is': [123, 135], 'modulator': [125], 'PML': [127], 'function': [128], 'dynamics': [130], 'ROS': [132], 'signaling': [133], 'protectively': [136], 'involved': [137], 'pathogenesis': [140], 'diseases.': [143]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2154108215', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-13T16:41:52.470682', 'created_date': '2016-06-24'}