Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2153973178', 'doi': None, 'title': 'Evidence for the involvement of a bis-diol-epoxide in the metabolic activation of dibenz[a,h]anthracene to DNA-binding species in mouse skin.', 'display_name': 'Evidence for the involvement of a bis-diol-epoxide in the metabolic activation of dibenz[a,h]anthracene to DNA-binding species in mouse skin.', 'publication_year': 1993, 'publication_date': '1993-03-01', 'ids': {'openalex': 'https://openalex.org/W2153973178', 'mag': '2153973178', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8439967'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8439967', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030567966', 'display_name': 'Paul L. Carmichael', 'orcid': 'https://orcid.org/0000-0003-1353-9032'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Paul L. Carmichael', 'raw_affiliation_strings': ['Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, United Kingdom', 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110014111', 'display_name': 'Karl L. Platt', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Karl L. Platt', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021137410', 'display_name': 'Meadhbh Ní Shé', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Meadhbh Ní Shé', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001864197', 'display_name': 'Sophie Lecoq', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Sophie Lecoq', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046143290', 'display_name': 'Franz Oesch', 'orcid': 'https://orcid.org/0000-0002-7607-1329'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Franz Oesch', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034188143', 'display_name': 'David H. Phillips', 'orcid': 'https://orcid.org/0000-0001-8509-3485'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'David H. Phillips', 'raw_affiliation_strings': ['Analytical & Environmental Sciences'], 'affiliations': [{'raw_affiliation_string': 'Analytical & Environmental Sciences', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103475939', 'display_name': 'Philip L. Grover', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Philip L. Grover', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.547, 'has_fulltext': False, 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.665559, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '53', 'issue': '5', 'first_page': '944', 'last_page': '8'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10433', 'display_name': 'Carcinogens and Genotoxicity Assessment', 'score': 0.673, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10433', 'display_name': 'Carcinogens and Genotoxicity Assessment', 'score': 0.673, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/7,12-dimethylbenz[a]anthracene', 'display_name': '7,12-Dimethylbenz[a]anthracene', 'score': 0.7228569}, {'id': 'https://openalex.org/keywords/dna-adduct', 'display_name': 'DNA adduct', 'score': 0.6200799}], 'concepts': [{'id': 'https://openalex.org/C2779563022', 'wikidata': 'https://www.wikidata.org/wiki/Q422152', 'display_name': 'Anthracene', 'level': 2, 'score': 0.930524}, {'id': 'https://openalex.org/C108204754', 'wikidata': 'https://www.wikidata.org/wiki/Q353392', 'display_name': 'Adduct', 'level': 2, 'score': 0.91012275}, {'id': 'https://openalex.org/C2779515768', 'wikidata': 'https://www.wikidata.org/wiki/Q421916', 'display_name': 'Diol', 'level': 2, 'score': 0.75541395}, {'id': 'https://openalex.org/C2776260934', 'wikidata': 'https://www.wikidata.org/wiki/Q187487', 'display_name': '7,12-Dimethylbenz[a]anthracene', 'level': 5, 'score': 0.7228569}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.719342}, {'id': 'https://openalex.org/C2781247443', 'wikidata': 'https://www.wikidata.org/wiki/Q4153410', 'display_name': 'DNA adduct', 'level': 3, 'score': 0.6200799}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.5589125}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.54254496}, {'id': 'https://openalex.org/C2776920199', 'wikidata': 'https://www.wikidata.org/wiki/Q408028', 'display_name': 'Epoxide', 'level': 3, 'score': 0.5147395}, {'id': 'https://openalex.org/C114246631', 'wikidata': 'https://www.wikidata.org/wiki/Q187661', 'display_name': 'Carcinogen', 'level': 2, 'score': 0.46213546}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.28980076}, {'id': 'https://openalex.org/C2778938436', 'wikidata': 'https://www.wikidata.org/wiki/Q5205596', 'display_name': 'DMBA', 'level': 4, 'score': 0.23381332}, {'id': 'https://openalex.org/C75473681', 'wikidata': 'https://www.wikidata.org/wiki/Q188651', 'display_name': 'Photochemistry', 'level': 1, 'score': 0.21003526}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.16957244}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.0599325}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.055316776}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.05311039}], 'mesh': [{'descriptor_ui': 'D001551', 'descriptor_name': 'Benz(a)Anthracenes', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004852', 'descriptor_name': 'Epoxy Compounds', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001551', 'descriptor_name': 'Benz(a)Anthracenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001711', 'descriptor_name': 'Biotransformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002851', 'descriptor_name': 'Chromatography, High Pressure Liquid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002855', 'descriptor_name': 'Chromatography, Thin Layer', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004852', 'descriptor_name': 'Epoxy Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8439967', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 17, 'referenced_works': ['https://openalex.org/W1542868541', 'https://openalex.org/W1557191181', 'https://openalex.org/W1970502777', 'https://openalex.org/W1995131475', 'https://openalex.org/W2038144895', 'https://openalex.org/W2059874056', 'https://openalex.org/W2062119488', 'https://openalex.org/W2064627839', 'https://openalex.org/W2065515991', 'https://openalex.org/W2071363055', 'https://openalex.org/W2091026604', 'https://openalex.org/W2091311321', 'https://openalex.org/W2128442121', 'https://openalex.org/W2333169696', 'https://openalex.org/W2335293225', 'https://openalex.org/W2398836562', 'https://openalex.org/W2398862422'], 'related_works': ['https://openalex.org/W2323083101', 'https://openalex.org/W2153973178', 'https://openalex.org/W2053782898', 'https://openalex.org/W2035052729', 'https://openalex.org/W2032828696', 'https://openalex.org/W2031343589', 'https://openalex.org/W2020166580', 'https://openalex.org/W1985980320', 'https://openalex.org/W1972989989', 'https://openalex.org/W1556456745'], 'abstract_inverted_index': {'Dibenz[a,h]anthracene': [0], '(DB[a,h]A)': [1], 'and': [2, 14, 24, 58, 116, 149, 189], 'its': [3], 'microsomal': [4], 'metabolites,': [5], 'trans-3,4-dihydro-3,4-dihydroxydibenz[a,h]anthracene': [6], '(DBA-3,4-diol),': [7], 'trans,trans-3,4:8,9-tetrahydro-3,4:8,9-tetrahydroxydibenz[a,h]anth': [8], 'racene,': [9], 'trans,trans-3,4:10,11-tetrahydro-3,4:10,11-tetrahydroxydibenz[a,h]': [10], '-': [11], 'anthracene': [12], '(DBA-3,4,10,11-bis-diol)': [13], 'trans,trans-3,4:12,13-tetrahydro-3,4:12,13-': [15], 'tetrahydroxydibenz[a,h]anthracene': [16], 'were': [17, 76], 'each': [18, 35], 'applied': [19], 'topically': [20], 'to': [21, 96, 178, 186, 191], 'mouse': [22, 170], 'skin': [23], 'the': [25, 37, 109, 131, 138, 143, 172, 187, 195], 'epidermal': [26], 'DNA': [27, 38, 42, 74, 179], 'isolated': [28], '24': [29], 'h': [30], 'later.': [31], '32P-postlabeling': [32], 'analysis': [33], 'of': [34, 36, 55, 66, 142, 175], 'samples': [39], 'was': [40, 68, 87, 94, 122, 156], 'performed.': [41], 'from': [43, 147, 154], 'mice': [44], 'treated': [45], 'with': [46, 108, 137, 151], 'DB[a,h]A': [47, 115, 148, 176], 'produced': [48, 69, 77, 88, 112, 134], 'an': [49], 'adduct': [50, 61, 85, 101, 111, 121, 133], 'map': [51], 'on': [52, 104, 159], 'TLC': [53], 'consisting': [54], 'one': [56], 'major': [57, 99, 110, 144, 173], 'three': [59], 'minor': [60, 84], 'spots.': [62], 'A': [63], 'similar': [64], 'pattern': [65], 'spots': [67], 'by': [70, 78, 89, 113, 135], 'DBA-3,4-diol.': [71, 117], 'No': [72], 'detectable': [73], 'adducts': [75, 145], 'trans,trans-3,4:12,13-tetrahydro-3,4:12,13-tetrahydroxy-': [79], 'dibenz[a,h]anthracene,': [80], 'although': [81], 'a': [82, 98, 125, 184, 192], 'single,': [83], 'spot': [86], 'trans,trans-3,4:8,9-tetrahydro-3,4:8,9-tetrahydroxydibenz[a,h]-': [90], 'anthracene.': [91], 'However,': [92], 'DBA-3,4,10,11-bis-diol': [93, 155], 'found': [95], 'produce': [97], 'single': [100], 'that': [102, 152], 'comigrated': [103], 'thin': [105], 'layer': [106], 'chromatography': [107], 'both': [114], 'In': [118], 'addition,': [119], 'this': [120], 'present': [123], 'at': [124], 'level': [126], '10': [127], 'times': [128], 'higher': [129], 'than': [130], 'corresponding': [132], 'treatment': [136], 'parent': [139], 'hydrocarbon.': [140], 'Coelution': [141], 'formed': [146, 153], 'DBA-3,4-diol': [150], 'also': [157], 'demonstrated': [158], 'reverse-phase': [160], 'high': [161], 'performance': [162], 'liquid': [163], 'chromatography.': [164], 'Thus,': [165], 'we': [166], 'propose': [167], 'that,': [168], 'in': [169], 'skin,': [171], 'pathway': [174], 'activation': [177], 'binding': [180], 'products': [181], 'is': [182], 'via': [183], '3,4-diol': [185], '3,4,10,11-bis-diol': [188], 'ultimately': [190], 'bis-diol-epoxide': [193], '(potentially': [194], '3,4,10,11-bis-dihydrodiol-1,2-oxide).': [196]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2153973178', 'counts_by_year': [{'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-12-10T04:51:47.577664', 'created_date': '2016-06-24'}