The Effects of the Polyglutamine Repeat Protein Ataxin-1 on the UbL-UBA Protein A1Up

Name: Work Video:
Duration: 3 min 30 s
Brigit E. Riley; Yifan Xu; Huda Y. Zoghbi; Harry T. Orr
{'id': 'https://openalex.org/W2153912626', 'doi': 'https://doi.org/10.1074/jbc.m406284200', 'title': 'The Effects of the Polyglutamine Repeat Protein Ataxin-1 on the UbL-UBA Protein A1Up', 'display_name': 'The Effects of the Polyglutamine Repeat Protein Ataxin-1 on the UbL-UBA Protein A1Up', 'publication_year': 2004, 'publication_date': '2004-07-27', 'ids': {'openalex': 'https://openalex.org/W2153912626', 'doi': 'https://doi.org/10.1074/jbc.m406284200', 'mag': '2153912626', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15280365'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m406284200', 'pdf_url': 'http://www.jbc.org/article/S0021925820726992/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820726992/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113771494', 'display_name': 'Brigit E. Riley', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210150971', 'display_name': 'Institute of Molecular Biology and Biophysics', 'ror': 'https://ror.org/051f11n17', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I1313323035', 'https://openalex.org/I4210110862', 'https://openalex.org/I4210150971']}, {'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['RU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Brigit E. Riley', 'raw_affiliation_strings': ['Departments of Biochemistry, Molecular Biology, and Biophysics and', 'Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota 55455 and', 'Laboratory Medicine and Pathology'], 'affiliations': [{'raw_affiliation_string': 'Departments of Biochemistry, Molecular Biology, and Biophysics and', 'institution_ids': ['https://openalex.org/I4210150971']}, {'raw_affiliation_string': 'Laboratory Medicine and Pathology', 'institution_ids': []}, {'raw_affiliation_string': 'Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota 55455 and', 'institution_ids': ['https://openalex.org/I130238516']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101509044', 'display_name': 'Yifan Xu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yifan Xu', 'raw_affiliation_strings': ['Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota 55455 and'], 'affiliations': [{'raw_affiliation_string': 'Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota 55455 and', 'institution_ids': ['https://openalex.org/I130238516']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020701219', 'display_name': 'Huda Y. Zoghbi', 'orcid': 'https://orcid.org/0000-0002-0700-3349'}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Huda Y. Zoghbi', 'raw_affiliation_strings': ['Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I181547552']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005772078', 'display_name': 'Harry T. Orr', 'orcid': 'https://orcid.org/0000-0001-6118-741X'}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}, {'id': 'https://openalex.org/I4210150971', 'display_name': 'Institute of Molecular Biology and Biophysics', 'ror': 'https://ror.org/051f11n17', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I1313323035', 'https://openalex.org/I4210110862', 'https://openalex.org/I4210150971']}], 'countries': ['RU', 'US'], 'is_corresponding': True, 'raw_author_name': 'Harry T. Orr', 'raw_affiliation_strings': ['Departments of Biochemistry, Molecular Biology, and Biophysics and', 'Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota 55455 and', 'Laboratory Medicine and Pathology'], 'affiliations': [{'raw_affiliation_string': 'Laboratory Medicine and Pathology', 'institution_ids': []}, {'raw_affiliation_string': 'Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota 55455 and', 'institution_ids': ['https://openalex.org/I130238516']}, {'raw_affiliation_string': 'Departments of Biochemistry, Molecular Biology, and Biophysics and', 'institution_ids': ['https://openalex.org/I4210150971']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5005772078'], 'corresponding_institution_ids': ['https://openalex.org/I130238516', 'https://openalex.org/I4210150971'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.02, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 46, 'citation_normalized_percentile': {'value': 0.885459, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '279', 'issue': '40', 'first_page': '42290', 'last_page': '42301'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10949', 'display_name': 'Genetic Neurodegenerative Diseases', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.41735545}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m406284200', 'pdf_url': 'http://www.jbc.org/article/S0021925820726992/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m406284200', 'pdf_url': 'http://www.jbc.org/article/S0021925820726992/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W1528984990', 'https://openalex.org/W1541511139', 'https://openalex.org/W1570470474', 'https://openalex.org/W1588279803', 'https://openalex.org/W1600472471', 'https://openalex.org/W1622884348', 'https://openalex.org/W1625642974', 'https://openalex.org/W1708445842', 'https://openalex.org/W1969561251', 'https://openalex.org/W1979105476', 'https://openalex.org/W1988170942', 'https://openalex.org/W1988617344', 'https://openalex.org/W1991291237', 'https://openalex.org/W1996997340', 'https://openalex.org/W1997858645', 'https://openalex.org/W1998879017', 'https://openalex.org/W2010538192', 'https://openalex.org/W2015392890', 'https://openalex.org/W2020232365', 'https://openalex.org/W2025331058', 'https://openalex.org/W2025450862', 'https://openalex.org/W2033010341', 'https://openalex.org/W2034447651', 'https://openalex.org/W2036727875', 'https://openalex.org/W2037454778', 'https://openalex.org/W2038345597', 'https://openalex.org/W2040298188', 'https://openalex.org/W2046511938', 'https://openalex.org/W2052159338', 'https://openalex.org/W2056020080', 'https://openalex.org/W2058441186', 'https://openalex.org/W2061478357', 'https://openalex.org/W2062636623', 'https://openalex.org/W2062759979', 'https://openalex.org/W2068399149', 'https://openalex.org/W2068806054', 'https://openalex.org/W2073991273', 'https://openalex.org/W2080625914', 'https://openalex.org/W2097062199', 'https://openalex.org/W2098663288', 'https://openalex.org/W2111301002', 'https://openalex.org/W2113019206', 'https://openalex.org/W2113998330', 'https://openalex.org/W2116015530', 'https://openalex.org/W2120947942', 'https://openalex.org/W2144593863', 'https://openalex.org/W2150123812', 'https://openalex.org/W2157036573', 'https://openalex.org/W2157247790', 'https://openalex.org/W2157295566', 'https://openalex.org/W2157618233', 'https://openalex.org/W2163813747', 'https://openalex.org/W2168079270', 'https://openalex.org/W2169482727', 'https://openalex.org/W4252368281'], 'related_works': ['https://openalex.org/W4234157524', 'https://openalex.org/W2788277189', 'https://openalex.org/W2151865869', 'https://openalex.org/W2130076355', 'https://openalex.org/W2119695867', 'https://openalex.org/W2117258802', 'https://openalex.org/W2082860237', 'https://openalex.org/W2013243191', 'https://openalex.org/W1993764875', 'https://openalex.org/W1990804418'], 'abstract_inverted_index': {'The': [0, 98, 131, 195, 293, 326, 585, 1149, 1249, 1276, 1291, 1665, 1813, 2443, 2453, 2496, 2534, 2695, 2728, 2762, 2999, 3160, 3229, 3286, 3320, 3332, 3353, 3516, 3684], 'ataxin-1': [1, 196, 540, 648, 822, 846, 852, 2340, 2403, 2700, 4338, 4375], 'interacting': [2, 197, 413, 853], 'ubiquitin-like': [3, 9, 198, 204, 854], 'protein': [4, 199, 855, 1684, 2957, 3000, 3006, 3025, 4195], '(A1Up)': [5, 200, 856], 'contains': [6, 201, 1258, 1303, 3867], 'an': [7, 20, 35, 202, 215, 230, 419, 455, 663, 2124, 3713], 'amino-terminal': [8, 203, 927, 3534], '(UbL)': [10, 205], 'region,': [11, 206], 'four': [12, 207, 1576], 'stress-inducible,': [13, 208], 'heat': [14, 209], 'shock': [15, 210], 'chaperonin-binding': [16, 211], 'motifs': [17, 212, 1506], '(STI1),': [18, 213], 'and': [19, 37, 108, 139, 148, 168, 179, 214, 232, 303, 334, 343, 363, 374, 430, 483, 489, 561, 657, 823, 903, 938, 1173, 1200, 1262, 1320, 1322, 1357, 1367, 1501, 1585, 1636, 1744, 1838, 2121, 2224, 2331, 2361, 2374, 2395, 2414, 2432, 2451, 2465, 2550, 2622, 2666, 2680, 2746, 2810, 2832, 2837, 2877, 2961, 3024, 3059, 3073, 3081, 3094, 3103, 3127, 3185, 3218, 3232, 3272, 3292, 3338, 3385, 3435, 3445, 3454, 3475, 3485, 3497, 3511, 3586, 3620, 3625, 3741, 3776, 3825, 3962, 4087, 4104, 4130, 4141, 4172, 4175, 4209, 4257, 4270, 4279, 4304, 4363, 4392, 4481], 'ubiquitin-associated': [21, 216, 907], 'domain': [22, 39, 100, 133, 158, 217, 234, 295, 328, 353, 908, 945, 1110, 1837, 1845, 3606, 3747, 3769, 3861, 3943, 3961], '(UBA)': [23, 218, 909], 'at': [24, 219, 654, 2756, 2842, 2941, 2948, 2980, 2990, 2996, 3031, 3154, 3283, 3329, 3362, 3782, 3982, 3987, 4381, 4384], 'the': [25, 61, 68, 73, 77, 81, 84, 90, 93, 128, 144, 150, 156, 161, 172, 175, 183, 220, 256, 263, 268, 272, 276, 279, 285, 288, 323, 339, 345, 351, 356, 367, 370, 378, 440, 449, 461, 473, 557, 607, 617, 621, 666, 763, 826, 885, 926, 943, 954, 960, 1098, 1108, 1112, 1162, 1166, 1203, 1254, 1259, 1263, 1274, 1287, 1304, 1313, 1349, 1355, 1362, 1365, 1386, 1399, 1451, 1504, 1512, 1581, 1679, 1682, 1695, 1750, 1828, 1972, 2183, 2200, 2207, 2317, 2321, 2326, 2333, 2348, 2356, 2362, 2369, 2372, 2384, 2397, 2407, 2437, 2752, 2765, 2778, 2802, 2853, 2965, 3114, 3236, 3278, 3326, 3398, 3431, 3455, 3460, 3527, 3530, 3542, 3546, 3549, 3555, 3591, 3601, 3604, 3608, 3616, 3673, 3694, 3726, 3731, 3745, 3752, 3767, 3772, 3777, 3785, 3846, 3852, 3859, 3863, 3903, 3910, 3923, 3941, 3959, 3968, 4076, 4120, 4148, 4178, 4183, 4187, 4193, 4200, 4260, 4271, 4280, 4287, 4295, 4325, 4330, 4340, 4347, 4349, 4373, 4466, 4472, 4483], 'carboxyl': [26, 221, 905], 'terminus': [27, 222, 899, 906], 'of': [28, 63, 70, 76, 92, 101, 118, 125, 134, 146, 153, 163, 185, 223, 258, 265, 271, 287, 296, 313, 320, 329, 341, 348, 358, 380, 432, 442, 467, 538, 547, 556, 613, 623, 659, 668, 821, 825, 845, 888, 925, 930, 946, 951, 1097, 1111, 1115, 1159, 1165, 1205, 1253, 1270, 1286, 1328, 1348, 1507, 1575, 1668, 1681, 1692, 1746, 1823, 1968, 1974, 2114, 2126, 2202, 2206, 2215, 2320, 2329, 2335, 2337, 2350, 2359, 2364, 2371, 2377, 2399, 2410, 2964, 3112, 3235, 3518, 3529, 3533, 3557, 3603, 3618, 3677, 3686, 3689, 3701, 3733, 3766, 3793, 3795, 3799, 3803, 3848, 3851, 3855, 3874, 3912, 3938, 3955, 3975, 4073, 4078, 4080, 4089, 4093, 4122, 4158, 4180, 4186, 4192, 4199, 4207, 4219, 4251, 4273, 4289, 4298, 4308, 4333, 4342, 4465, 4474, 4485], 'A1Up.': [29, 154, 224, 349, 2378, 3589, 4334], 'Although': [30, 225], 'proteins': [31, 226, 615, 889, 948, 1317, 1815, 1970, 2116, 2173, 2684, 3537], 'that': [32, 116, 227, 311, 424, 452, 597, 819, 890, 942, 1198, 1257, 1267, 1325, 1390, 1437, 1735, 2347, 2381, 2396, 3541, 3712, 3815, 3840, 3858, 3866, 3953, 3978, 4085, 4127, 4151, 4197, 4210, 4321, 4377], 'have': [33, 228, 891, 940, 2174, 2467], 'both': [34, 106, 229, 301, 833, 1284, 3958, 4079, 4128], 'UbL': [36, 62, 99, 231, 257, 294, 928, 944, 1109, 1204, 1683, 1844, 2373, 3535, 3556, 3605, 3617, 3746, 3768, 3860, 3960], 'UBA': [38, 132, 157, 233, 327, 352, 1836, 2375, 3727, 3942, 3963], 'are': [40, 51, 235, 246, 476, 832, 1168, 3551, 3612, 3761, 4091], 'thought': [41, 236, 1359], 'to': [42, 57, 127, 237, 252, 322, 604, 620, 626, 651, 662, 671, 884, 896, 953, 959, 1105, 1107, 1154, 1208, 1354, 1360, 1498, 1633, 1642, 1694, 1749, 1818, 1827, 2119, 2178, 2198, 2218, 2352, 2386, 2401, 2455, 2543, 2662, 2677, 2698, 2737, 2978, 3046, 3171, 3267, 3276, 3374, 3383, 3406, 3524, 3580, 3597, 3622, 3691, 3807, 3997, 4134, 4166, 4216, 4291, 4344, 4468], 'play': [43, 238, 590], 'a': [44, 141, 239, 336, 443, 545, 601, 772, 838, 892, 904, 1300, 1323, 2388, 2558, 2923, 2930, 2971, 2984, 3035, 3039, 3675, 3734, 3764, 3791, 3826, 4108], 'crucial': [45, 240], 'role': [46, 142, 241, 337, 586, 1667, 3765], 'in': [47, 89, 143, 149, 242, 284, 338, 344, 448, 454, 591, 774, 830, 843, 1151, 1202, 1394, 1675, 1678, 1732, 1742, 1977, 2123, 2391, 2806, 2812, 2862, 3063, 3098, 3365, 3410, 3433, 3459, 3477, 3503, 3554, 3588, 3615, 3730, 3770, 3831, 4075, 4110, 4119, 4389, 4394], 'proteasome-mediated': [48, 243], 'activities,': [49, 244], 'few': [50, 245], 'characterized,': [52, 247], 'except': [53, 248], 'for': [54, 67, 122, 249, 262, 317, 554, 835, 1157, 1511, 2445, 2463, 2498, 2620, 2793, 2845, 2945, 2970, 2993, 3038, 3092, 3120, 3143, 3280, 3359, 3467, 3494, 3522, 3545, 3600, 4169, 4329], 'hHR23A/B.': [55, 250], 'Similar': [56, 251], 'other': [58, 253, 474, 2540, 3993], 'UbL-containing': [59, 254], 'proteins,': [60, 255, 931, 1310], 'A1Up': [64, 71, 102, 112, 119, 126, 135, 147, 164, 178, 259, 266, 297, 307, 314, 321, 330, 342, 359, 373, 882, 2330, 2338, 2351, 2365, 2382, 2400, 3519, 3523, 3539, 3558, 3619, 3669, 3690, 3722, 3724, 3743, 3775, 3781, 3808, 3824, 3841, 3856, 3913, 3939, 3956, 4074, 4099, 4112, 4135, 4152, 4181, 4256, 4274, 4290, 4299, 4311, 4343, 4362], 'is': [65, 103, 113, 120, 260, 298, 308, 315, 418, 425, 437, 465, 544, 593, 1326, 1358, 1385, 1730, 1740, 2117, 2404, 3862, 3872, 4153, 4323], 'essential': [66, 261], 'interaction': [69, 82, 176, 264, 277, 371, 1158, 1363, 2336, 3547, 3602, 3714, 3773, 4179, 4478], 'with': [72, 83, 171, 267, 278, 366, 760, 1161, 1281, 1509, 1639, 1699, 2339, 2354, 2687, 2840, 2886, 2922, 2956, 3131, 3179, 3252, 3259, 3312, 3342, 3349, 3388, 3402, 3439, 3480, 3526, 3538, 3548, 3607, 3672, 3693, 3715, 3719, 3751, 3763, 3901, 3991, 4116, 4144, 4182, 4267, 4310, 4346, 4352, 4479], 'S5a': [74, 269, 1209, 3394, 4184], 'subunit': [75, 270, 964, 1096, 1164, 1278, 1389, 3611, 4185], '19S': [78, 85, 129, 273, 280, 324, 955, 1264, 1277, 1293, 3753, 4188], 'proteasome.': [79, 130, 173, 274, 325, 368, 3778, 4189], 'Importantly,': [80, 275], 'proteasome': [86, 281, 411, 559, 828, 1167, 1251, 1388, 1401, 1443, 1452, 1696, 1751, 1829, 2730, 2779, 3180, 3237, 3550, 3695, 3735, 3754, 4170], 'was': [87, 159, 165, 282, 354, 360, 649, 770, 779, 841, 857, 949, 2460, 2500, 2660, 2675, 2701, 2731, 2780, 2937, 3002, 3123, 3129, 3140, 3294, 3322, 3425, 3696, 3717, 3842, 3926, 4107, 4276, 4312, 4356], 'disrupted': [88, 283], 'presence': [91, 286, 3732, 4077, 4121], 'polyglutamine': [94, 289, 458, 470, 2408], 'repeat': [95, 290, 446, 471], 'protein,': [96, 291], 'ataxin-1.': [97, 292, 2411], 'ubiquitinated': [104, 299, 1271, 3876, 4293], 'by': [105, 300, 427, 439, 1445, 1697, 2186, 2628, 2789, 2929, 2939, 2988, 3336, 3346, 3428, 3499, 3508, 3594, 3698, 3845, 4156], 'Lys48-linked': [107, 302, 1577, 2210], 'Lys63-linked': [109, 304, 4131], 'chains.': [110, 305], 'Intact': [111, 306], 'stable,': [114, 309], 'suggesting': [115, 310, 1734, 3952, 4084, 4126], 'ubiquitination': [117, 312, 3911, 3937, 3954, 4113, 4136, 4218, 4250, 4275, 4332], 'important': [121, 316, 4168], 'degradation-independent': [123, 318, 1690], 'targeting': [124, 319, 1691, 4171], 'binds': [136, 331, 1587], 'polyubiquitin': [137, 332, 961, 1502, 1831, 2211, 2219, 4095, 4160], 'chains': [138, 333, 1573, 1589, 1638, 1644, 4132, 4161], 'has': [140, 335, 1101, 1434, 1495, 1629, 1671, 2190, 2195, 2383, 4386], 'stability': [145, 340], 'subcellular': [151, 346, 2357], 'localization': [152, 162, 347, 357, 2358], 'When': [155, 350], 'deleted,': [160, 355], 'entirely': [166, 361], 'cytoplasmic,': [167, 362], 'it': [169, 364, 1433], 'co-localized': [170, 365], 'Interestingly,': [174, 369], 'between': [177, 372, 1364, 3774], 'mutant': [180, 375, 539, 669, 756, 4281, 4368, 4376, 4475], 'ataxin-1-(82Q)': [181, 376, 670, 757], 'increased': [182, 377, 780], 'half-life': [184, 379, 2363], 'A1Up,': [186, 381, 2360, 2664, 3216, 3820, 4252], 'whereas': [187, 382], 'nonpathogenic': [188, 383], 'wild-type': [189, 384, 4117, 4365], 'ataxin-1-(30Q)': [190, 385, 4366], 'or': [191, 386, 1283, 2204, 2555, 2774, 3020, 3392, 3397, 3723, 3986, 4124, 4259, 4294, 4367], 'ataxin-1-(82Q)-A776': [192, 387, 745], 'did': [193, 388, 3748, 3934, 4284], 'not.': [194, 389], 'Spinocerebellar': [390], 'ataxia': [391, 401], 'type': [392, 402], '1': [393, 2976, 3281, 3468, 3740], '(SCA1)': [394], '1The': [395], 'abbreviations': [396], 'used': [397, 2661, 2676, 2697, 3091, 3124, 3142, 3830, 3927], 'are:': [398], 'SCA1,': [399], 'spinocerebellar': [400, 477], '1;': [403], 'HA,': [404], 'hemagglutinin;': [405], 'E3,': [406], 'ubiquitin-protein': [407], 'isopeptide': [408], 'ligase;': [409], 'PLIC,': [410], 'ligation': [412], 'component;': [414], 'ER,': [415], 'endoplasmic': [416], 'reticulum.': [417], 'inherited': [420], 'progressive': [421], 'neurodegenerative': [422], 'disease': [423, 748, 781], 'characterized': [426, 469, 2332], 'motor': [428], 'deterioration': [429], 'loss': [431], 'cerebellar': [433], 'Purkinje': [434], 'cells.': [435], 'SCA1': [436, 450, 464, 624, 831, 4390, 4486], 'caused': [438], 'expansion': [441], 'CAG': [444], 'trinucleotide': [445], 'tract': [447, 459], 'gene': [451], 'results': [453, 2122, 3760], 'abnormally': [456], 'long': [457], 'within': [460], 'protein.': [462], 'Thus,': [463], 'one': [466, 1282, 1738, 2203, 3347, 3980], 'nine': [468], 'diseases;': [472], 'eight': [475], 'ataxias': [478], '2,': [479, 3917], '3,': [480], '6,': [481, 2546], '7,': [482], '17;': [484], 'dentatorubral-pallidoluysian': [485], 'atrophy;': [486], "Huntington's": [487], 'disease;': [488], 'spinobulbar': [490], 'muscular': [491], 'atrophy': [492], '(1Zoghbi': [493, 2416], 'H.Y.': [494, 574, 696, 722, 800, 868, 2417, 2484, 2515, 2716, 3204, 3886, 4419, 4445], 'Orr': [495, 571, 691, 725, 795, 869, 2418, 2485, 2518, 2717, 3205, 3887, 4414, 4448], 'H.T.': [496, 572, 692, 726, 796, 870, 2419, 2486, 2519, 2718, 3206, 3888, 4415, 4449], 'Annu.': [497, 2420], 'Rev.': [498, 915, 1337, 1374, 1458, 1599, 2421], 'Neurosci.': [499, 2422], '2000;': [500, 874, 1048, 2037, 2259, 2423, 2584, 3892, 4018], '23:': [501, 2424], '217-247Crossref': [502, 2425], 'PubMed': [503, 532, 580, 642, 706, 736, 810, 877, 919, 992, 1011, 1034, 1056, 1090, 1144, 1189, 1230, 1244, 1341, 1378, 1427, 1462, 1489, 1541, 1567, 1603, 1622, 1660, 1724, 1777, 1808, 1864, 1895, 1910, 1935, 1955, 2002, 2017, 2040, 2067, 2087, 2107, 2150, 2167, 2239, 2262, 2289, 2309, 2426, 2491, 2529, 2592, 2613, 2650, 2723, 2913, 3211, 3573, 3647, 3661, 3895, 4026, 4047, 4065, 4238, 4429, 4459], 'Scopus': [504, 533, 581, 643, 707, 737, 811, 878, 920, 993, 1012, 1035, 1057, 1091, 1145, 1190, 1231, 1245, 1342, 1379, 1428, 1463, 1490, 1542, 1568, 1604, 1623, 1661, 1725, 1778, 1809, 1865, 1896, 1911, 1936, 1956, 2003, 2018, 2041, 2068, 2088, 2108, 2151, 2168, 2240, 2263, 2290, 2310, 2427, 2492, 2530, 2593, 2614, 2651, 2724, 2914, 3212, 3574, 3648, 3662, 3896, 4027, 4048, 4066, 4239, 4430, 4460], '(1103)': [505, 2428], 'Google': [506, 535, 583, 645, 709, 739, 813, 880, 922, 995, 1014, 1037, 1059, 1093, 1147, 1192, 1233, 1247, 1344, 1381, 1430, 1465, 1492, 1544, 1570, 1606, 1625, 1663, 1727, 1780, 1811, 1867, 1898, 1913, 1938, 1958, 2005, 2020, 2043, 2070, 2090, 2110, 2153, 2170, 2242, 2265, 2292, 2312, 2429, 2494, 2532, 2595, 2616, 2653, 2726, 2916, 3214, 3576, 3650, 3664, 3898, 4029, 4050, 4068, 4241, 4432, 4462], 'Scholar,': [507, 710, 996, 1015, 1038, 1060, 1234, 1466, 1545, 1607, 1781, 1868, 1899, 1914, 1939, 2006, 2021, 2044, 2071, 2091, 2154, 2243, 2266, 2293, 2596, 3651, 4030, 4051, 4433], '2Nakamura': [508], 'K.': [509, 517, 972, 976, 1082, 1084, 1521, 1525, 1903, 2010, 2033, 2232, 2255, 2480, 2712, 3200], 'Jeong': [510], 'S.Y.': [511], 'Uchihara': [512], 'T.': [513, 519, 718, 974, 1019, 1021, 1523, 1849, 1851, 1987, 1989, 2077, 2079, 2135, 2137, 2511, 4441], 'Anno': [514], 'M.': [515, 968, 1017, 1123, 1410, 1477, 1517, 1555, 1760, 1789, 1847, 1874, 1918, 1922, 1924, 1985, 2050, 2056, 2058, 2073, 2133, 2272, 2278, 2280, 2602, 2631, 4036], 'Nagashima': [516, 518], 'Ikeda': [520], 'S.': [521, 523, 1029, 1070, 1072, 1119, 1225, 1404, 1406, 1471, 1702, 1754, 1756, 1785, 1792, 1859, 1870, 1997, 2054, 2075, 2093, 2145, 2156, 2276, 2295, 2898, 2908, 3642, 4222], 'Tsuji': [522], 'Kanazawa': [524], 'I.': [525, 1416, 1766, 2158], 'Hum.': [526, 871, 3889], 'Mol.': [527, 872, 1421, 1771, 1904, 2011, 2061, 2233, 2283, 3890], 'Genet.': [528, 576, 873, 3891], '2001;': [529, 1932, 2064, 2286, 2610, 4044], '10:': [530], '1441-1448Crossref': [531], '(548)': [534], 'Scholar).': [536, 584, 646, 740, 814, 881, 923, 1094, 1148, 1193, 1248, 1345, 1382, 1431, 1493, 1571, 1626, 1664, 1728, 1812, 1959, 2111, 2171, 2313, 2495, 2533, 2617, 2654, 2727, 2917, 3215, 3577, 3665, 3899, 4069, 4242, 4463], 'Accumulation': [537], 'into': [541, 616, 1273, 1299, 2436], 'nuclear': [542, 550, 588, 598, 673, 775], 'inclusions': [543, 551, 589, 599, 618, 674], 'hallmark': [546], 'disease.': [548], 'These': [549, 815, 3578, 3759], 'stain': [552], 'positive': [553], 'components': [555], 'ubiquitin': [558, 827, 893, 2130, 2226, 2537, 3804, 3828, 3969, 3977, 4090, 4205], 'pathway': [560], 'chaperones': [562], '(3Cummings': [563], 'C.J.': [564, 784, 2476, 2708, 3196], 'Mancini': [565], 'M.A.': [566], 'Antalffy': [567, 789], 'B.': [568, 790, 862, 1129, 1880, 3880], 'DeFranco': [569], 'D.B.': [570], 'Zoghbi': [573, 695, 721, 799, 867, 2483, 2514, 2715, 3203, 3885, 4418, 4444], 'Nat.': [575, 1138, 1889, 1929, 2034, 2256], '1998;': [577, 1559, 1800, 2642], '19:': [578], '148-154Crossref': [579], '(752)': [582], 'these': [587, 947, 1588, 1669, 2342, 3450, 3687, 3816, 4081], 'pathogenesis': [592, 4391], 'complex.': [594], 'Data': [595], 'suggest': [596, 818], 'represent': [600], 'cellular': [602, 3702, 3821, 4173, 4253, 4359], 'response': [603], 'protect': [605], 'against': [606], 'expanded': [608, 4374], 'polyglutamine,': [609], 'but': [610, 777, 2860], 'whether': [611, 3668, 4245, 4337], 'sequestration': [612], 'normal': [614], 'contributes': [619], 'pathology': [622, 782], 'remains': [625], 'be': [627, 652, 1155, 1296, 1392, 1819, 2199, 3598, 4167, 4292, 4379], 'determined': [628, 3004], '(4Ciechanover': [629], 'A.': [630, 688, 794, 913, 1030, 1226, 1335, 1372, 1456, 1597, 1860, 1943, 1998, 2146, 2482, 2574, 2714, 2909, 3202, 3643, 4008, 4411], 'Brundin': [631], 'P.': [632, 678, 1547, 2025, 2247, 4401], 'Neuron.': [633, 727, 801, 2520, 4450], '2003;': [634, 698, 728, 1087, 1227, 1241, 2099, 2301, 2521, 2910, 3644, 3658, 4421, 4451], '40:': [635], '427-446Abstract': [636], 'Full': [637, 639, 701, 703, 731, 733, 805, 807, 987, 989, 1051, 1053, 1484, 1486, 1536, 1538, 1562, 1564, 1655, 1657, 1719, 1721, 1803, 1805, 1950, 1952, 2102, 2104, 2304, 2306, 2524, 2526, 2587, 2589, 2645, 2647, 4021, 4023, 4060, 4062, 4233, 4235, 4424, 4426, 4454, 4456], 'Text': [638, 640, 702, 704, 732, 734, 806, 808, 988, 990, 1052, 1054, 1485, 1487, 1537, 1539, 1563, 1565, 1656, 1658, 1720, 1722, 1804, 1806, 1951, 1953, 2103, 2105, 2305, 2307, 2525, 2527, 2588, 2590, 2646, 2648, 4022, 4024, 4061, 4063, 4234, 4236, 4425, 4427, 4455, 4457], 'PDF': [641, 705, 735, 809, 991, 1055, 1488, 1540, 1566, 1659, 1723, 1807, 1954, 2106, 2308, 2528, 2591, 2649, 4025, 4064, 4237, 4428, 4458], '(817)': [644], 'Recently,': [647], 'reported': [650], 'phosphorylated': [653, 4380], 'serine': [655, 661, 4467], '776,': [656], 'mutation': [658], 'this': [660, 850, 1964, 2188, 3146, 4176], 'alanine': [664, 4469], 'decreased': [665], 'ability': [667, 2349, 2385, 2398, 3685, 4288, 4341], 'form': [672, 3925], '(5Chen': [675, 4398], 'H.K.': [676, 4399], 'Fernandez-Funez': [677, 4400], 'Acevedo': [679, 4402], 'S.F.': [680, 4403], 'Lam': [681, 4404], 'Y.C.': [682, 4405], 'Kaytor': [683, 713, 2506, 4406, 4436], 'M.D.': [684, 714, 2160, 2507, 4407, 4437], 'Fernandez': [685, 4408], 'M.H.': [686, 911, 1333, 1370, 1454, 1595, 4409], 'Aitken': [687, 4410], 'Skoulakis': [689, 4412], 'E.M.': [690, 4413], 'Botas': [693, 4416], 'J.': [694, 981, 1040, 1042, 1044, 1045, 1068, 1238, 1240, 1478, 1530, 1556, 1649, 1704, 1712, 1713, 1797, 1944, 2083, 2096, 2161, 2298, 2563, 2576, 2606, 2639, 3655, 3657, 4010, 4040, 4227, 4417], 'Cell.': [697, 1422, 1772, 1905, 2012, 2062, 2234, 2284, 2583, 4017, 4056, 4420], '113:': [699, 4422], '457-468Abstract': [700, 4423], '(355)': [708, 4431], '6Emamian': [711, 4434], 'E.S.': [712, 2505, 4435], 'Duvick': [715, 865, 2508, 3883, 4438], 'L.A.': [716, 866, 2509, 3884, 4439], 'Zu': [717, 2510, 4440], 'Tousey': [719, 2512, 4442], 'S.K.': [720, 2513, 4443], 'Clark': [723, 2516, 4446], 'H.B.': [724, 2517, 4447], '38:': [729, 2522, 4452], '375-387Abstract': [730, 2523, 4453], '(266)': [738, 2531, 4461], 'Furthermore,': [741, 1194, 1432, 2112, 3590, 4306], 'transgenic': [742, 753, 4395], 'mice': [743], 'expressing': [744, 3823, 4255, 4361], 'had': [746], 'reduced': [747], 'pathology.': [749], 'In': [750, 3300], 'contrast,': [751], 'when': [752, 3922], 'animals': [754, 761], 'overexpressing': [755], 'were': [758, 1816, 2434, 2449, 2557, 2625, 2685, 2750, 2767, 2804, 2855, 2920, 2954, 3029, 3054, 3061, 3090, 3096, 3150, 3164, 3177, 3220, 3238, 3250, 3288, 3308, 3334, 3356, 3400, 3416, 3452, 3457, 3471, 3491, 3680, 3818, 3829, 3919, 4265], 'crossed': [759], 'lacking': [762, 3725, 3744, 3940], 'E3': [764, 4201, 4326], 'ligase,': [765], 'E6AP': [766, 2679, 2681, 4203, 4214, 4246, 4258, 4263, 4278, 4282, 4309, 4322], '(Ube3A': [767], 'gene),': [768], 'there': [769, 778], 'also': [771, 1102, 1352, 1630, 2175, 2501, 3141, 3552, 3613, 3789, 4248, 4371], 'decrease': [773, 4109], 'inclusions,': [776], '(7Cummings': [783], 'Reinstein': [785], 'E.': [786, 1062, 1066, 2570, 4004], 'Sun': [787], 'Y.': [788, 792, 1064, 1080], 'Jiang': [791], 'Ciechanover': [793, 912, 1334, 1371, 1455, 1596], 'Beaudet': [797], 'A.L.': [798, 1648, 2634, 4224], '1999;': [802, 984, 1533, 2084, 4057, 4230], '24:': [803], '879-892Abstract': [804], '(446)': [812], 'latter': [816, 1513], 'experiments': [817], 'modifications': [820], 'modulation': [824], 'system': [829], 'critical': [834, 1156], 'pathogenesis.': [836], 'Previously,': [837], 'two-hybrid': [839], 'screen': [840], 'performed': [842, 3130, 3295, 4357], 'search': [844], 'binding': [847, 952, 1833, 1841], 'partners.': [848], 'From': [849], 'screen,': [851], 'identified': [858], '(8Davidson': [859, 3877], 'J.D.': [860, 3878], 'Riley': [861, 3879], 'Burright': [863, 3881], 'E.N.': [864, 3882], '9:': [875, 3893], '2305-2312Crossref': [876, 3894], '(77)': [879, 3897], 'belongs': [883], 'UbL-UBA': [886, 1814, 1969, 2115, 2172], 'family': [887, 929], 'moiety': [894], 'fused': [895], 'their': [897, 1835, 1843, 1982], 'amino': [898], '(ubiquitin-like': [900], 'domain,': [901], 'UbL)': [902], '(9Glickman': [910, 1332, 1369, 1453, 1594], 'Physiol.': [914, 1336, 1373, 1457, 1598], '2002;': [916, 1008, 1031, 1141, 1186, 1338, 1375, 1459, 1600, 1619, 1716, 1861, 1892, 1907, 1947, 1999, 2014, 2147, 2236, 3570], '82:': [917, 1339, 1376, 1460, 1601], '373-428Crossref': [918, 1340, 1377, 1461, 1602], '(3352)': [921, 1343, 1380, 1464, 1605], 'Studies': [924], 'such': [932], 'as': [933, 1580, 2857, 2883, 2888, 3056, 3182, 3188, 3418, 3513, 4114], 'hHR23A/B,': [934], 'hPLIC1/2,': [935], 'Dsk-2,': [936], 'BAG-1,': [937, 1685], 'Parkin,': [939], 'demonstrated': [941], 'capable': [950, 1822, 3873, 4092], 'proteasome,': [956, 1099, 3674, 4348], 'more': [957, 1736, 2205], 'specifically,': [958], 'receptor': [962], 'Rpn10/S5a': [963, 1163, 1384, 1440, 1494, 1586, 1628, 1700, 1840, 3609], '(10Hiyama': [965, 1514], 'H.': [966, 1023, 1074, 1076, 1412, 1515, 1710, 1762, 1783, 1853, 1941, 1991, 2081, 2139], 'Yokoi': [967, 1516], 'Masutani': [969, 1518], 'C.': [970, 1519, 1706, 1926, 1928, 2031, 2253, 2568, 2578, 2580, 2598, 4002, 4012, 4014, 4032], 'Sugasawa': [971, 1520], 'Maekawa': [973, 1522], 'Tanaka': [975, 1081, 1524], 'Hoeijmakers': [977, 1526], 'J.H.': [978, 1527], 'Hanaoka': [979, 1528], 'F.': [980, 1133, 1529, 1884], 'Biol.': [982, 1046, 1140, 1423, 1479, 1531, 1557, 1650, 1714, 1773, 1798, 1891, 1906, 1931, 1945, 2013, 2036, 2063, 2097, 2163, 2235, 2258, 2285, 2299, 2640, 4228], 'Chem.': [983, 1047, 1480, 1532, 1558, 1651, 1715, 1799, 1946, 2098, 2300, 2641, 4229], '274:': [985, 1534, 4231], '28019-28025Abstract': [986, 1535], '(228)': [994, 1543], '11Walters': [997, 1608], 'K.J.': [998, 1176, 1211, 1609, 3560, 3628], 'Kleijnen': [999, 1177, 1610, 3561], 'M.F.': [1000, 1178, 1611, 3562], 'Goh': [1001, 1179, 1214, 1612, 3563, 3631], 'A.M.': [1002, 1180, 1215, 1613, 3564, 3632], 'Wagner': [1003, 1181, 1614, 3565], 'G.': [1004, 1182, 1615, 2048, 2270, 3566], 'Howley': [1005, 1183, 1218, 1616, 2632, 2637, 3567, 3635, 4225], 'P.M.': [1006, 1184, 1219, 1617, 2638, 3568, 3636, 4226], 'Biochemistry.': [1007, 1185, 1618, 3569], '41:': [1009, 1187, 1620, 3571], '1767-1777Crossref': [1010, 1188, 1621, 3572], '(189)': [1013, 1191, 1624, 3575], '12Funakoshi': [1016], 'Sasaki': [1018, 1848, 1986, 2134], 'Nishimoto': [1020, 1850, 1988, 2078, 2136], 'Kobayashi': [1022, 1852, 1990, 2080, 2138], 'Proc.': [1024, 1220, 1854, 1992, 2140, 2903, 3637], 'Natl.': [1025, 1221, 1855, 1993, 2141, 2904, 3638], 'Acad.': [1026, 1222, 1856, 1994, 2142, 2905, 3639], 'Sci.': [1027, 1223, 1857, 1995, 2143, 2906, 3640], 'U.': [1028, 1224, 1858, 1996, 2144, 2907, 3641], '99:': [1032, 1862, 2000, 2148], '745-750Crossref': [1033, 1863, 2001, 2149], '(208)': [1036, 1866, 2004, 2152], '13Luders': [1039], 'Demand': [1041, 1703], 'Hohfeld': [1043, 1711], '275:': [1049], '4613-4617Abstract': [1050], '(391)': [1058], '14Sakata': [1061], 'Yamaguchi': [1063], 'Kurimoto': [1065], 'Kikuchi': [1067], 'Yokoyama': [1069], 'Yamada': [1071], 'Kawahara': [1073], 'Yokosawa': [1075], 'Hattori': [1077], 'N.': [1078, 1708], 'Mizuno': [1079], 'Kato': [1083], 'EMBO': [1085, 1239, 2082, 3656], 'Rep.': [1086], '4:': [1088, 1142, 1893], '301-306Crossref': [1089], '(230)': [1092], 'Another': [1095], 'Rpn1,': [1100], 'been': [1103, 1435, 1496, 1631, 1673, 2176, 2192, 2196, 2468, 4387], 'shown': [1104, 1153, 1497, 1632, 2177, 4165], 'bind': [1106, 1207, 1353, 1499, 1634], 'yeast': [1113, 1978, 2120], 'homolog': [1114], 'hHR23,': [1116], 'Rad23': [1117], '(15Elsasser': [1118], 'Gali': [1120, 1871], 'R.R.': [1121, 1872], 'Schwickart': [1122, 1873], 'Larsen': [1124, 1875], 'C.N.': [1125, 1876], 'Leggett': [1126, 1877], 'D.S.': [1127, 1878], 'Muller': [1128, 1879], 'Feng': [1130, 1881], 'M.T.': [1131, 1882], 'Tubing': [1132, 1883], 'Dittmar': [1134, 1885], 'G.A.': [1135, 1886], 'Finley': [1136, 1417, 1767, 1793, 1887], 'D.': [1137, 1418, 1473, 1768, 1794, 1888, 2027, 2249], 'Cell': [1139, 1890, 1930, 2035, 2162, 2257, 2743, 2935], '725-730Crossref': [1143, 1894], '(379)': [1146, 1897], 'residues': [1150, 2447, 3543, 3581, 3592, 3623, 3869, 3995], 'hPLIC-1': [1152, 1160], 'Ile79,': [1169], 'Ala81,': [1170], 'Ile84,': [1171], 'Val105,': [1172], 'Ile106': [1174], '(11Walters': [1175, 3559], 'mutagenesis': [1195, 3595], 'studies': [1196, 3596, 4191], 'showed': [1197, 4196], 'Thr9': [1199, 3624], 'Ile49': [1201], 'hHR23A': [1206, 4194, 4208, 4220], '(16Walters': [1210, 3627], 'Lech': [1212, 3629], 'P.J.': [1213, 2472, 2704, 3192, 3630], 'Wang': [1216, 2567, 3633, 4001], 'Q.': [1217, 1468, 1549, 3634], '100:': [1228, 2911, 3645], '12694-12699Crossref': [1229, 3646], '(126)': [1232, 3649], '37Mueller': [1235, 3652], 'T.D.': [1236, 3653], 'Feigon': [1237, 3654], '22:': [1242, 1908, 2015, 2237, 3659], '4634-4645Crossref': [1243, 3660], '(110)': [1246, 3663], '26S': [1250], 'consists': [1252], '20S': [1255, 1288, 2729, 2738, 3230], 'core': [1256, 1289], 'catalytic': [1260], 'activity': [1261], 'regulatory': [1265, 1315], 'particle': [1266, 1294, 1307, 1316], 'controls': [1268], 'entry': [1269], 'substrates': [1272, 1448, 1748, 1826, 1976], '20S.': [1275], 'can': [1279, 1295, 1351, 1391, 1441], 'associate': [1280], 'ends': [1285], 'particle.': [1290], '18-subunit': [1292], 'further': [1297, 2315, 3966], 'divided': [1298], 'base,': [1301, 1350], 'which': [1302, 2187], 'AAA-ATPases': [1305], '(regulatory': [1306], 'triple': [1308], 'A': [1309], 'Rpts': [1311], '1–6),': [1312], 'non-ATPase': [1314], '(Rpn1,': [1318], 'Rpn2,': [1319], 'Rpn10),': [1321], 'lid': [1324, 1356, 1368], 'comprised': [1327], 'non-ATPases': [1329], '(Rpn': [1330], '3–13)': [1331], 'Rpn10/S5a,': [1346, 1508], 'part': [1347], 'stabilize': [1361, 2387, 2402], 'base': [1366], 'Moreover,': [1383], 'only': [1387, 3729, 3864], 'found': [1393], 'large': [1395], 'abundance': [1396], 'disassociated': [1397], 'from': [1398, 1449, 2560, 2975, 3043], 'intact': [1400], '(18van': [1402, 1752], 'Nocker': [1403, 1470, 1753, 1791], 'Sadis': [1405, 1755, 1784], 'Rubin': [1407, 1757, 1786], 'D.M.': [1408, 1758, 1787], 'Glickman': [1409, 1759, 1788], 'Fu': [1411, 1761], 'Coux': [1413, 1763], 'O.': [1414, 1764], 'Wefes': [1415, 1765], 'Vierstra': [1419, 1474, 1769, 1795], 'R.D.': [1420, 1770, 1796], '1996;': [1424, 1652, 1774, 2164], '16:': [1425, 1775], '6020-6028Crossref': [1426, 1776], '(356)': [1429, 1779], 'suggested': [1436], 'excess': [1438], 'free': [1439], 'inhibit': [1442], 'degradation': [1444, 1583, 1973, 1983], 'sequestering': [1446, 2209], 'polyubiquitinated': [1447, 1747, 1825], 'reaching': [1450], '19Deveraux': [1467], 'van': [1469, 1790], 'Mahaffey': [1472], 'R.': [1475, 1920], 'Rechsteiner': [1476, 1554], '1995;': [1481], '270:': [1482], '29660-29663Abstract': [1483], '(83)': [1491], 'monoubiquitin': [1500, 2222], 'through': [1503, 1591, 1834], 'ubiquitin-interacting': [1505], 'preference': [1510], '20Young': [1546], 'Deveraux': [1548], 'Beal': [1550], 'R.E.': [1551], 'Pickart': [1552, 2094, 2296, 2579, 4013, 4054], 'C.M.': [1553, 2095, 2297, 4055], '273:': [1560, 1801, 2643], '5461-5467Abstract': [1561], '(265)': [1569], 'Polyubiquitin': [1572], 'consisting': [1574], 'ubiquitins': [1578], 'function': [1579], 'canonical': [1582], 'signal,': [1584], 'primarily': [1590], 'hydrophobic': [1592], 'interactions': [1593], 'However,': [1627, 1960, 3932], 'Lys6': [1635], 'Lys11': [1637, 1686], 'equal': [1640], 'affinity': [1641], 'Lys48': [1643, 2554, 4086], '(21Baboshina': [1645], 'O.V.': [1646], 'Haas': [1647], '271:': [1653], '2823-2831Abstract': [1654], '(183)': [1662, 2915], 'exact': [1666, 2184], 'linkages': [1670, 4163], 'not': [1672, 2191, 3749, 3920, 3935, 4285, 4313, 4316, 4324], 'studied': [1674], 'depth;': [1676], 'however,': [1677, 2182], 'case': [1680], 'chain': [1687, 1832, 2227, 3805, 4096], 'formation': [1688, 4097, 4157], 'facilitates': [1689], 'BAG-1': [1693], 'association': [1698], '(22Alberti': [1701], 'Esser': [1705], 'Emmerich': [1707], 'Schild': [1709], '277:': [1717, 1948], '45920-45927Abstract': [1718], '(161)': [1726, 1810], 'Rpn10': [1729], 'nonessential': [1731], 'yeast,': [1733], 'than': [1737, 1980], 'factor': [1739], 'involved': [1741], 'recognition': [1743], 'delivery': [1745], '23Fu': [1782], '1970-1981Abstract': [1802], 'hypothesized': [1817, 2197], '"shuttle': [1820], 'factors"': [1821], 'delivering': [1824], 'via': [1830, 1842], 'subsequent': [1839], '(12Funakoshi': [1846, 1984, 2132], '15Elsasser': [1869], '24Chen': [1900, 2007], 'L.': [1901, 2008, 2029, 2230, 2251, 2566, 2572, 2600, 4000, 4006, 4034], 'Madura': [1902, 2009, 2032, 2231, 2254], '4902-4913Crossref': [1909, 2016, 2238], '(252)': [1912, 2019, 2241], '25Wilkinson': [1915], 'C.R.': [1916], 'Seeger': [1917], 'Hartmann-Petersen': [1919], 'Stone': [1921], 'Wallace': [1923], 'Semple': [1925], 'Gordon': [1927], '3:': [1933], '939-943Crossref': [1934], '(349)': [1937], '26Rao': [1940], 'Sastry': [1942], '11691-11695Abstract': [1949], '(177)': [1957], 'recent': [1961], 'findings': [1962], 'contradict': [1963], 'shuttle': [1965], 'hypothesis.': [1966], 'Overexpression': [1967], 'inhibits': [1971, 4477], 'model': [1975], 'rather': [1979], 'stimulating': [1981], '27Ortolan': [2022, 2244], 'T.G.': [2023, 2245], 'Tongaonkar': [2024, 2246], 'Lambertson': [2026, 2248], 'Chen': [2028, 2250, 2564, 2581, 2607, 4015, 4041], 'Schauber': [2030, 2252], '2:': [2038, 2260], '601-608Crossref': [2039, 2261], '(160)': [2042, 2264], '28Clarke': [2045, 2267], 'D.J.': [2046, 2268], 'Mondesert': [2047, 2269], 'Segal': [2049, 2271], 'Bertolaet': [2051, 2273], 'B.L.': [2052, 2274], 'Jensen': [2053, 2275], 'Wolff': [2055, 2277], 'Henze': [2057, 2279], 'Reed': [2059, 2281], 'S.I.': [2060, 2282], '21:': [2065, 2287], '1997-2007Crossref': [2066, 2288], '(76)': [2069, 2291], '29Funakoshi': [2072], 'Geley': [2074], 'Hunt': [2076], '18:': [2085], '5009-5018Crossref': [2086], '(52)': [2089], '30Raasi': [2092, 2294], '278:': [2100, 2302], '8951-8959Abstract': [2101, 2303], '(206)': [2109, 2311], 'overexpression': [2113, 4198], 'toxic': [2118], 'accumulation': [2125], 'high': [2127, 3115, 3905], 'molecular': [2128, 3110, 3116, 3797, 3906], 'mass': [2129, 3111, 3117, 3798, 3907], 'species': [2131], '31Biggins': [2155], 'Ivanovska': [2157], 'Rose': [2159], '133:': [2165], '1331-1346Crossref': [2166], '(147)': [2169], 'exert': [2179], 'stabilizing': [2180], 'effects;': [2181], 'means': [2185], 'occurs': [2189], 'determined.': [2193, 4277], 'It': [2194], 'result': [2201], 'following:': [2208], 'chains;': [2212, 2220, 2223], 'blocking': [2213], 'access': [2214], 'deubiquitinating': [2216], 'enzymes': [2217], 'capping': [2221], 'inhibiting': [2225], 'assembly': [2228], '(24Chen': [2229], 'To': [2314, 2796, 3108, 3666, 3813, 3965, 4243, 4335], 'explore': [2316], 'biological': [2318], 'implications': [2319], 'A1Up/ataxin-1': [2322], 'association,': [2323], 'we': [2324, 2345, 3933, 3971, 4319], 'defined': [2325], 'biochemical': [2327], 'properties': [2328], 'effects': [2334], 'on': [2341, 2368, 2406, 2983, 3034, 3325, 4098], 'properties.': [2343], 'Here': [2344], 'show': [2346, 2380, 4150], 'interact': [2353, 3671, 3692, 3750, 4345], 'S5a,': [2355], 'all': [2366, 3992], 'depend': [2367], 'integrity': [2370], 'domains': [2376], 'We': [2379, 4070, 4370], 'specific': [2389], 'substrate': [2390], 'vivo,': [2392], 'namely,': [2393], 'ataxin-1,': [2394], 'dependent': [2405], 'length': [2409], 'Expression': [2412, 2618], 'Constructs': [2413], 'Antibodies—A1Up': [2415], 'Scholar),': [2430], 'ΔUbL,': [2431, 2446, 2665, 3217], 'ΔUBA': [2433, 2457, 3219], 'cloned': [2435], 'mammalian': [2438], 'expression': [2439], 'vector': [2440], 'pcDNA3.1': [2441], '(Invitrogen).': [2442, 2772, 3107, 3169], 'primers': [2444], '115–700,': [2448], '5′-cggaattcctgcttcttccccctccac-3′': [2450], '5′-cggaattcgctgtctcatctccctcttc-3′.': [2452], 'primer': [2454], 'construct': [2456], '(residues': [2458], '1–600)': [2459], '5′-cggaattccacctgtgagtttcgacttcca-3′.': [2461], 'Plasmids': [2462], 'pCDNA1Amp-ataxin-1-(30Q)': [2464], 'pCDNA1Amp-ataxin-1-(82Q)': [2466], 'described': [2469, 2502, 2858, 2884, 2889, 3057, 3183, 3189, 3514], 'previously': [2470, 2503, 3190, 4164], '(32Skinner': [2471, 2703, 3191], 'Koshy': [2473, 2705, 3193], 'B.T.': [2474, 2706, 3194], 'Cummings': [2475, 2707, 3195], 'Klement': [2477, 2709, 3197], 'I.A.': [2478, 2710, 3198], 'Helin': [2479, 2711, 3199], 'Servadio': [2481, 2713, 3201], 'Nature.': [2487, 2609, 2719, 3207, 4043], '1997;': [2488, 2720, 3208], '389:': [2489, 2721, 3209], '971-974Crossref': [2490, 2722, 3210], '(499)': [2493, 2725, 3213], 'plasmid': [2497], 'pCDNA-ataxin-1-(82Q)-A776': [2499], '(6Emamian': [2504], 'single': [2535], 'lysine': [2536, 3868, 3981], 'plasmids': [2538, 2619], '(with': [2539], 'lysines': [2541, 3994], 'mutated': [2542, 3996], 'arginines': [2544], 'including': [2545], '11,': [2547], '27,': [2548], '29,': [2549], '33)': [2551], 'pER-HA-Ub': [2552], '(or': [2553], 'Lys63)': [2556], 'gift': [2559], 'Dr.': [2561, 2629], 'Zhijian': [2562], '(33Deng': [2565, 3999], 'Spencer': [2569, 4003], 'Yang': [2571, 4005], 'Braun': [2573, 4007], 'You': [2575, 4009], 'Slaughter': [2577, 4011], 'Z.J.': [2582, 2608, 4016, 4042], '103:': [2585, 4019], '351-361Abstract': [2586, 4020], '(1513)': [2594, 4028], '34Wang': [2597, 4031], 'Deng': [2599, 4033], 'Hong': [2601, 4035], 'Akkaraju': [2603, 4037], 'G.R.': [2604, 4038], 'Inoue': [2605, 4039], '412:': [2611, 4045], '346-351Crossref': [2612, 4046], '(1639)': [2615, 4049], 'pCMV4-HA-E6AP': [2621, 2623], '(C833A)': [2624, 4213, 4264, 4283], 'kindly': [2626], 'provided': [2627], 'Peter': [2630], '(35Talis': [2633], 'Huibregtse': [2635], 'J.M.': [2636], '6439-6445Abstract': [2644], '(203)': [2652], 'Mouse': [2655, 2668], 'monoclonal': [2656, 2669, 2689, 3015, 3224, 3389, 3393, 3786], 'anti-Xpress': [2657, 3225, 3787, 4268], 'antibody': [2658, 2671, 2690, 2696, 2736, 2963, 3016, 3226, 3245, 3257, 3265, 3391, 3788], '(Invitrogen)': [2659, 3089, 3405], 'detect': [2663, 2678], 'ΔUBA.': [2667], 'anti-HA': [2670], '(Santa': [2672], 'Cruz': [2673], 'Biotechnology)': [2674], '(C833A).': [2682], 'Ubiquitylated': [2683], 'detected': [2686, 2732, 3239, 3718, 3790, 3921, 4314], 'mouse': [2688, 3223], '(clone': [2691], 'FK2;': [2692], 'Affiniti,': [2693, 3247, 3318], 'UK).': [2694, 2742, 3248, 3319], 'immunoprecipitate': [2699], '11NQ': [2702, 3021], 'using': [2733, 2769, 2782, 3005, 3084, 3145, 3166, 3222, 3240, 3296, 3376, 3704, 4358], 'rabbit': [2734, 3241], 'polyclonal': [2735, 3242], 'α/β': [2739, 3244], 'subunits': [2740, 3234], '(Affiniti,': [2741, 3395], 'Transfection,': [2744], 'Immunoprecipitation,': [2745], 'Native': [2747], 'Electrophoresis—COS-1': [2748], 'cells': [2749, 2766, 2792, 2803, 2854, 3053, 3060, 3149, 3176, 3305, 3415, 3432, 3456], 'plated': [2751, 3151], 'day': [2753], 'before': [2754], 'transfection': [2755], '5': [2757], '×': [2758, 2943, 3156], '106': [2759], 'cells/60-mm': [2760], 'plate.': [2761, 3159], 'following': [2763, 3161], 'day,': [2764, 3162], 'transfected': [2768, 2791, 3055, 3165, 3417], 'LipofectAMINE': [2770, 3167], 'Plus': [2771, 3168], 'Twenty-four': [2773, 3170], '48': [2775, 3172, 3984], 'h': [2776, 2977, 3045, 3173, 3282], 'later,': [2777, 3449], 'inhibited': [2781], 'clasto-lactacystin': [2783], 'β-lactone': [2784], '(20': [2785], 'μm;': [2786], 'Boston': [2787], 'Biochemicals)': [2788], 'treating': [2790], '6–7': [2794], 'h.': [2795, 3469], 'harvest': [2797], 'extracts': [2798, 2919, 2953, 3703, 3822, 4254, 4360], 'under': [2799, 2850], 'nondenaturing': [2800], 'conditions,': [2801, 2852], 'washed': [2805, 2856, 3339, 3472], 'ice-cold': [2807, 3504], 'phosphate-buffered': [2808, 3505], 'saline': [2809, 3506], 'lysed': [2811, 2861], '50': [2813, 2863, 3064, 3464], 'mm': [2814, 2819, 2822, 2864, 2869, 3065, 3068, 3071], 'Tris-HCl': [2815, 3350], '(pH': [2816, 2866, 3351], '7.5),': [2817], '2.5': [2818], 'MgCl2,': [2820], '100': [2821], 'NaCl,': [2823, 2870, 3069], '0.5%': [2824, 2874, 3074], 'Triton': [2825, 2872, 3075], 'X-100,': [2826, 2873], '1×': [2827], 'protease': [2828, 2881], 'inhibitors': [2829, 2882], '(Roche': [2830], 'Biochemicals),': [2831], 'phosphatase': [2833], 'inhibitor': [2834, 3181], 'cocktails': [2835], 'I': [2836], 'II': [2838], '(Sigma)': [2839], 'rocking': [2841, 2887], '4': [2843, 2949, 2981, 2997, 3032, 3044, 3330, 4142], '°C': [2844, 2982, 3033, 3364], '15': [2846], 'min.': [2847], 'For': [2848, 2951, 3048], 'immunoprecipitations': [2849], 'denaturing': [2851, 3832], 'above': [2859, 2890, 3184, 3420], 'Tris': [2865], '8.0),': [2867], '150': [2868], '1%': [2871], 'sodium': [2875], 'deoxycholate,': [2876], '0.1%': [2878], 'SDS': [2879], 'containing': [2880, 3463], 'above,': [2885, 3058], '(36Donaldson': [2891], 'K.M.': [2892], 'Li': [2893], 'W.': [2894], 'Ching': [2895], 'K.A.': [2896], 'Batalov': [2897], 'Tsai': [2899], 'C.C.': [2900], 'Joazeiro': [2901], 'C.A.': [2902], '8892-8897Crossref': [2912], 'All': [2918], 'sheared': [2921], '21-gauge': [2924], 'needle': [2925, 2932], '(10': [2926], 'times),': [2927], 'followed': [2928, 2987, 3345, 3507], '25-gauge': [2931], '(4': [2933], 'times).': [2934], 'debris': [2936], 'pelleted': [2938], 'centrifugation': [2940, 2989, 3337], '14,000': [2942], 'g': [2944], '10': [2946, 3070, 3360], 'min': [2947, 3361], '°C.': [2950, 2998, 3285, 3331], 'immunoprecipitation,': [2952], 'precleared': [2955], 'G-Sepharose': [2958], '(Amersham': [2959, 3125], 'Biosciences)': [2960], 'nonspecific': [2962], 'same': [2966, 3461], 'isotype': [2967], '(0.5': [2968], 'μg)': [2969, 3311], 'time': [2972, 3040], 'period': [2973, 3041], 'ranging': [2974, 3042], 'overnight': [2979, 3324], 'rugged': [2985, 3036], 'rotator,': [2986], '12,000': [2991], 'rpm': [2992], '20': [2994], 's': [2995], 'concentration': [3001], 'then': [3003, 3186, 3357, 3492], 'dye': [3007, 3368], 'reagent': [3008], '(Bio-Rad).': [3009, 3299], 'Protein': [3010], 'extract': [3011], '(500': [3012, 3310], 'μg),': [3013], 'Xpress': [3014, 3390], '(1': [3017], 'μl;': [3018, 3317], 'Invitrogen)': [3019, 3083], '(1–2': [3022], 'μl),': [3023], 'G': [3026], '(50': [3027], 'μl)': [3028], 'incubated': [3030, 3251, 3309, 3323, 3476], 'rotator': [3037], 'overnight.': [3047], 'native': [3049, 3086, 3100, 3121], 'gel': [3050, 3366], 'electrophoresis,': [3051, 3093], 'COS-1': [3052, 3304], 'harvested': [3062], 'NaH2PO4,': [3066], '300': [3067], 'imidazole,': [3072], 'X-100.': [3076], 'Tris-glycine': [3077, 3085, 3099], 'gels': [3078, 3380, 3399], '(6%,': [3079], '8%,': [3080], '10%;': [3082], 'running': [3087], 'buffer': [3088, 3102], 'samples': [3095], 'prepared': [3097], 'sample': [3101], 'loaded': [3104], 'without': [3105], 'heating': [3106], 'estimate': [3109], 'unknowns,': [3113], 'calibration': [3118], 'kit': [3119], 'electrophoresis': [3122], 'Biosciences),': [3126], 'staining': [3128], 'Ponceau': [3132], 'Staining': [3133], 'Solution': [3134], '(Sigma).': [3135], 'Sigma': [3136], 'technical': [3137], 'bulletin': [3138], 'MKR-137': [3139], 'reference': [3144], 'procedure.': [3147], 'Immunofluorescence—COS-1-1': [3148], 'onto': [3152, 3290], 'coverslips': [3153, 3287], '2': [3155, 3837, 4303], '105': [3157], 'cells/6-well': [3158], 'they': [3163], 'after': [3174], 'transfection,': [3175], 'treated': [3178], 'immunostained': [3187], 'visualized': [3221], '(1:100;': [3227, 3261, 3269], 'Invitrogen).': [3228], 'α': [3231], 'β': [3233], 'anti-20S': [3243], '(1:2500;': [3246], 'Cells': [3249, 3470, 3490], 'three': [3253, 3340], 'secondary': [3254], 'antibodies:': [3255], 'anti-mouse': [3256], 'conjugated': [3258, 3266], 'Cy3': [3260], 'Jackson': [3262], 'Immunoresearch);': [3263], 'anti-rabbit': [3264], 'Alexa488': [3268], 'Molecular': [3270], 'Probes);': [3271], '4′,6-diamidino-2-phenylindole': [3273], '(1:1,000;': [3274], 'Sigma)': [3275], 'visualize': [3277], 'nucleus': [3279], '37': [3284], 'mounted': [3289], 'slides,': [3291], 'analysis': [3293, 4351], 'confocal': [3297], 'microscopy': [3298], 'Vitro': [3301], 'Binding': [3302], 'Assays—Transfected': [3303], '(48': [3306, 3421], 'h)': [3307], 'purified': [3313, 3705], 'GST-S5a-agarose': [3314], 'beads': [3315, 3333, 3355, 4355], '(30': [3316], 'mixture': [3321], 'rotating': [3327], 'wheel': [3328], 'collected': [3335, 3498], 'times': [3341, 3474, 3496, 3502], 'lysis': [3343, 3510], 'buffer,': [3344], 'wash': [3348], '7.5).': [3352], 'agarose': [3354, 3707, 4354], 'heated': [3358], '70': [3363], 'loading': [3367], 'plus': [3369], 'reducing': [3370], 'agent': [3371], '(Invitrogen),': [3372, 3381], 'subjected': [3373], 'SDS-PAGE': [3375], '4–12%': [3377], 'NuPAGE': [3378], 'Bis-Tris': [3379], 'transferred': [3382], 'nitrocellose,': [3384], 'Western': [3386], 'blotted': [3387], 'UK),': [3396], 'stained': [3401], 'Simply': [3403], 'Blue': [3404], 'determine': [3407, 4244], 'total': [3408, 4296], '19S/S5a': [3409, 3716], 'each': [3411], 'lane.': [3412], 'Pulse-Chase': [3413], 'Experiments—COS-1': [3414], 'indicated': [3419, 3540], 'h).': [3422], 'Metabolic': [3423], 'labeling': [3424], 'carried': [3426], 'out': [3427], 'first': [3429], 'starving': [3430], 'glutamine': [3434], 'methionine-free': [3436], 'media': [3437, 3451, 3462, 3478], 'supplemented': [3438, 3479], '5%': [3440], 'dialyzed': [3441], 'fetal': [3442, 3482], 'bovine': [3443, 3483], 'serum': [3444, 3484], 'l-glutamine.': [3446], 'One': [3447], 'hour': [3448], 'removed,': [3453], 'pulsed': [3458], 'μCi/ml': [3465], 'l-[35S]methionine': [3466], 'two': [3473, 3501], '10%': [3481], '180': [3486], 'μg/ml': [3487], 'unlabeled': [3488], 'methionine.': [3489], 'chased': [3493], 'various': [3495], 'washing': [3500], 'cell': [3509], 'immunoprecipitation': [3512], 'above.': [3515], 'Ubl': [3517], 'Is': [3520], 'Required': [3521], 'Interact': [3525], 'Proteasome—Examination': [3528], 'sequence': [3531, 3854], 'alignment': [3532], 'domain-containing': [3536], 'responsible': [3544, 3599, 4328], 'conserved': [3553, 3614], 'correspond': [3579, 3621], 'Ile55,': [3582], 'Ala57,': [3583], 'Ile60,': [3584], 'Val81,': [3585], 'Ile82': [3587], 'confirmed': [3593], 'proteasomal': [3610], 'Ile55': [3626], 'characterize': [3667, 3967], 'could': [3670, 4247], 'series': [3676, 3792], 'deletion': [3678], 'mutants': [3679, 3974], 'constructed': [3681], '(Fig.': [3682, 3737, 3755, 3809, 3914, 3928, 3944, 4100, 4137, 4300], '1A).': [3683], 'forms': [3688], 'examined': [3697], 'pull-down': [3699, 4350], 'analyses': [3700], '19S-(S5a)-GST': [3706, 4353], 'beads.': [3708], 'Fig.': [3709, 3834, 3948], '1B': [3710], 'shows': [3711, 3839, 3857], 'either': [3720, 4364], 'full-length': [3721], '(but': [3728], 'inhibitor)': [3736], '1B,': [3738, 3756, 3810, 3945], 'lanes': [3739, 4102, 4139, 4302], '3).': [3742, 3931, 4305], 'lane': [3757, 3811, 3836, 3916, 3930, 3946, 3950, 4145], '2).': [3758, 4146], 'consistent': [3762], 'mediating': [3771], 'Besides': [3779], 'detecting': [3780], '63.8': [3783], 'kDa,': [3784, 3801], 'bands': [3794, 3908], 'increasing': [3796], '∼10': [3800], 'suggestive': [3802], 'addition': [3806, 3847], '1).': [3812], 'verify': [3814], 'polypeptides': [3817], 'ubiquitin-modified': [3819], 'HA-tagged': [3827, 3976], 'immunoprecipitations.': [3833], '1C,': [3835, 3915, 3929, 3949], '(asterisks)': [3838], 'covalently': [3843, 4154], 'modified': [3844, 4155], 'ubiquitin.': [3849], 'Examination': [3850], 'primary': [3853], 'region': [3865], 'and,': [3870], 'thus,': [3871], 'being': [3875], 'Consistent': [3900], 'this,': [3902], 'distinct': [3904], 'reflecting': [3909], 'asterisks)': [3918], 'ΔUbL': [3924], 'observe': [3936], '3;': [3947], '4),': [3951], 'requires': [3957], 'domain.': [3964], 'chains,': [3970], 'utilized': [3972, 4372], 'single-lysine': [3973, 4082], 'contain': [3979], 'residue': [3983, 3988], '(Lys48)': [3985], '63': [3989], '(Lys63)': [3990], 'arginine': [3998], '38Hofmann': [4052], 'R.M.': [4053], '96:': [4058], '645-653Abstract': [4059], '(669)': [4067], 'observed': [4071, 4331], 'polyubiquitination': [4072], 'mutants,': [4083], 'Lys63': [4088], 'supporting': [4094], '1D,': [4101, 4138], '3': [4103, 4140], '4).': [4105], 'There': [4106], 'overall': [4111], 'compared': [4115, 4143], 'HA-ubiquitin': [4118], 'Ub(K48)': [4123], 'Ub(K63),': [4125], 'Lys48-': [4129], 'contribute': [4133], 'Overall,': [4147], 'data': [4149], 'complex': [4159], 'involving': [4162], 'signaling,': [4174], 'promotes': [4177], 'Previous': [4190], 'ligase': [4202, 4327], 'enhanced': [4204], 'modification': [4206], 'catalytically': [4211], 'inactive': [4212], 'failed': [4215], 'promote': [4217, 4249], '(39Kumar': [4221], 'Talis': [4223], '18785-18792Abstract': [4232], '(171)': [4240], 'dominant': [4261], 'negative': [4262], 'immunoprecipitated': [4266], 'antibody,': [4269], 'level': [4272], 'affect': [4286], 'levels': [4297], '1E,': [4301], 'co-immunoprecipitation': [4307], '(data': [4315], 'shown).': [4317], 'Therefore,': [4318], 'conclude': [4320], 'investigate': [4336], 'affects': [4339], 'ataxin-1-(82Q).': [4369], 'cannot': [4378], 'Ser776.': [4382], 'Phosphorylation': [4383], 'Ser776': [4385], 'implicated': [4388], 'progression': [4393], 'animal': [4396], 'models': [4397], 'Mutation': [4464], 'dramatically': [4470], 'decreases': [4471], 'aggregation': [4473], 'ataxin-1-(82Q),': [4476], '14-3-3,': [4480], 'modulates': [4482], 'pathogenicity': [4484]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2153912626', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-24T13:32:40.792750', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
