Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2153584160', 'doi': 'https://doi.org/10.1096/fj.03-1199fje', 'title': 'Cell death in amyotrophic lateral sclerosis: interplay between neuronal and glial cells', 'display_name': 'Cell death in amyotrophic lateral sclerosis: interplay between neuronal and glial cells', 'publication_year': 2004, 'publication_date': '2004-06-18', 'ids': {'openalex': 'https://openalex.org/W2153584160', 'doi': 'https://doi.org/10.1096/fj.03-1199fje', 'mag': '2153584160', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15208263'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fj.03-1199fje', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034183685', 'display_name': 'Alberto Ferri', 'orcid': 'https://orcid.org/0000-0002-4097-0605'}, 'institutions': [{'id': 'https://openalex.org/I4210150112', 'display_name': 'Fondazione Santa Lucia', 'ror': 'https://ror.org/05rcxtd95', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210150112', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Alberto Ferri', 'raw_affiliation_strings': ['Fondazione Santa Lucia, IRCCS Rome Italy', 'Ist di Neuroscienze CNR, Sez. Psicobiologia e Psicofarmacologia Rome Italy', 'Lab di NeurochimicaCentro di Neurobiologia Sperimentale “Mondino-Tor Vergata-S.Lucia” Rome Italy'], 'affiliations': [{'raw_affiliation_string': 'Ist di Neuroscienze CNR, Sez. Psicobiologia e Psicofarmacologia Rome Italy', 'institution_ids': []}, {'raw_affiliation_string': 'Lab di NeurochimicaCentro di Neurobiologia Sperimentale “Mondino-Tor Vergata-S.Lucia” Rome Italy', 'institution_ids': []}, {'raw_affiliation_string': 'Fondazione Santa Lucia, IRCCS Rome Italy', 'institution_ids': ['https://openalex.org/I4210150112', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026821813', 'display_name': 'Monica Nencini', 'orcid': 'https://orcid.org/0000-0001-9602-1954'}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Monica Nencini', 'raw_affiliation_strings': ['Lab di NeurochimicaCentro di Neurobiologia Sperimentale “Mondino-Tor Vergata-S.Lucia” Rome Italy'], 'affiliations': [{'raw_affiliation_string': 'Lab di NeurochimicaCentro di Neurobiologia Sperimentale “Mondino-Tor Vergata-S.Lucia” Rome Italy', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044254502', 'display_name': 'Arianna Casciati', 'orcid': 'https://orcid.org/0000-0003-2487-3060'}, 'institutions': [{'id': 'https://openalex.org/I4210150112', 'display_name': 'Fondazione Santa Lucia', 'ror': 'https://ror.org/05rcxtd95', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210150112', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Arianna Casciati', 'raw_affiliation_strings': ['Fondazione Santa Lucia, IRCCS Rome Italy'], 'affiliations': [{'raw_affiliation_string': 'Fondazione Santa Lucia, IRCCS Rome Italy', 'institution_ids': ['https://openalex.org/I4210150112', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064344624', 'display_name': 'Mauro Cozzolino', 'orcid': 'https://orcid.org/0000-0003-0342-8961'}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Mauro Cozzolino', 'raw_affiliation_strings': ['Lab di NeurochimicaCentro di Neurobiologia Sperimentale “Mondino-Tor Vergata-S.Lucia” Rome Italy'], 'affiliations': [{'raw_affiliation_string': 'Lab di NeurochimicaCentro di Neurobiologia Sperimentale “Mondino-Tor Vergata-S.Lucia” Rome Italy', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001260488', 'display_name': 'Daniela F. Angelini', 'orcid': 'https://orcid.org/0000-0003-4552-9226'}, 'institutions': [{'id': 'https://openalex.org/I4210150112', 'display_name': 'Fondazione Santa Lucia', 'ror': 'https://ror.org/05rcxtd95', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210150112', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Daniela F. Angelini', 'raw_affiliation_strings': ['Fondazione Santa Lucia, IRCCS Rome Italy'], 'affiliations': [{'raw_affiliation_string': 'Fondazione Santa Lucia, IRCCS Rome Italy', 'institution_ids': ['https://openalex.org/I4210150112', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014588475', 'display_name': 'Patrizia Longone', 'orcid': 'https://orcid.org/0000-0001-8964-1637'}, 'institutions': [{'id': 'https://openalex.org/I4210150112', 'display_name': 'Fondazione Santa Lucia', 'ror': 'https://ror.org/05rcxtd95', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210150112', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Patrizia Longone', 'raw_affiliation_strings': ['Fondazione Santa Lucia, IRCCS Rome Italy'], 'affiliations': [{'raw_affiliation_string': 'Fondazione Santa Lucia, IRCCS Rome Italy', 'institution_ids': ['https://openalex.org/I4210150112', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080586599', 'display_name': 'Alida Spalloni', 'orcid': 'https://orcid.org/0000-0002-2661-6677'}, 'institutions': [{'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210150112', 'display_name': 'Fondazione Santa Lucia', 'ror': 'https://ror.org/05rcxtd95', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210150112', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Alida Spalloni', 'raw_affiliation_strings': ['Fondazione Santa Lucia, IRCCS Rome Italy'], 'affiliations': [{'raw_affiliation_string': 'Fondazione Santa Lucia, IRCCS Rome Italy', 'institution_ids': ['https://openalex.org/I4210153126', 'https://openalex.org/I4210150112']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003998934', 'display_name': 'Giuseppe Rotilio', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giuseppe Rotilio', 'raw_affiliation_strings': ['Dipartimento di BiologiaUniversità di Roma “Tor Vergata,” Rome Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di BiologiaUniversità di Roma “Tor Vergata,” Rome Italy', 'institution_ids': ['https://openalex.org/I116067653']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002520527', 'display_name': 'Maria Teresa Carrı̀', 'orcid': 'https://orcid.org/0000-0002-1789-1546'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Maria Teresa Carrì', 'raw_affiliation_strings': ['Dipartimento di BiologiaUniversità di Roma “Tor Vergata,” Rome Italy', 'Lab di NeurochimicaCentro di Neurobiologia Sperimentale “Mondino-Tor Vergata-S.Lucia” Rome Italy'], 'affiliations': [{'raw_affiliation_string': 'Lab di NeurochimicaCentro di Neurobiologia Sperimentale “Mondino-Tor Vergata-S.Lucia” Rome Italy', 'institution_ids': []}, {'raw_affiliation_string': 'Dipartimento di BiologiaUniversità di Roma “Tor Vergata,” Rome Italy', 'institution_ids': ['https://openalex.org/I116067653']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.152, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 57, 'citation_normalized_percentile': {'value': 0.85371, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '18', 'issue': '11', 'first_page': '1261', 'last_page': '1263'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10855', 'display_name': 'Amyotrophic Lateral Sclerosis Research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10855', 'display_name': 'Amyotrophic Lateral Sclerosis Research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11266', 'display_name': 'Neuroinflammation and Neurodegeneration Mechanisms', 'score': 0.959, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12400', 'display_name': 'Neurogenetic and Muscular Disorders Research', 'score': 0.9487, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proinflammatory-cytokine', 'display_name': 'Proinflammatory cytokine', 'score': 0.48073912}], 'concepts': [{'id': 'https://openalex.org/C2777615887', 'wikidata': 'https://www.wikidata.org/wiki/Q15328137', 'display_name': 'SOD1', 'level': 4, 'score': 0.79245514}, {'id': 'https://openalex.org/C2780596555', 'wikidata': 'https://www.wikidata.org/wiki/Q206901', 'display_name': 'Amyotrophic lateral sclerosis', 'level': 3, 'score': 0.63171613}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5641855}, {'id': 'https://openalex.org/C164027704', 'wikidata': 'https://www.wikidata.org/wiki/Q3491837', 'display_name': 'Proinflammatory cytokine', 'level': 3, 'score': 0.48073912}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.46975684}, {'id': 'https://openalex.org/C2776752467', 'wikidata': 'https://www.wikidata.org/wiki/Q1133903', 'display_name': 'Motor neuron', 'level': 3, 'score': 0.46207622}, {'id': 'https://openalex.org/C2776715637', 'wikidata': 'https://www.wikidata.org/wiki/Q938205', 'display_name': 'Neuroblastoma', 'level': 3, 'score': 0.4478838}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.3593997}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.35805666}, {'id': 'https://openalex.org/C2775838275', 'wikidata': 'https://www.wikidata.org/wiki/Q410776', 'display_name': 'Superoxide dismutase', 'level': 3, 'score': 0.357674}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.31252652}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.290702}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.2240228}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.19192731}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.16425118}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.11750081}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.1093469}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.09974262}, {'id': 'https://openalex.org/C2780775167', 'wikidata': 'https://www.wikidata.org/wiki/Q9606', 'display_name': 'Spinal cord', 'level': 2, 'score': 0.08992255}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002450', 'descriptor_name': 'Cell Communication', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D016472', 'descriptor_name': 'Motor Neuron Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D009457', 'descriptor_name': 'Neuroglia', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020170', 'descriptor_name': 'Caspase 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020170', 'descriptor_name': 'Caspase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002374', 'descriptor_name': 'Catalase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002374', 'descriptor_name': 'Catalase', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D002450', 'descriptor_name': 'Cell Communication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018920', 'descriptor_name': 'Coculture Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016472', 'descriptor_name': 'Motor Neuron Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009046', 'descriptor_name': 'Motor Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009046', 'descriptor_name': 'Motor Neurons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D019331', 'descriptor_name': 'NG-Nitroarginine Methyl Ester', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019331', 'descriptor_name': 'NG-Nitroarginine Methyl Ester', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009457', 'descriptor_name': 'Neuroglia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020030', 'descriptor_name': 'Nitric Oxide Donors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020030', 'descriptor_name': 'Nitric Oxide Donors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D009603', 'descriptor_name': 'Nitroso Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009603', 'descriptor_name': 'Nitroso Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013116', 'descriptor_name': 'Spinal Cord', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': False}, {'descriptor_ui': 'D013116', 'descriptor_name': 'Spinal Cord', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D013116', 'descriptor_name': 'Spinal Cord', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072105', 'descriptor_name': 'Superoxide Dismutase-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fj.03-1199fje', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15208263', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 67, 'referenced_works': ['https://openalex.org/W1508556596', 'https://openalex.org/W1545372895', 'https://openalex.org/W1567632117', 'https://openalex.org/W1629086159', 'https://openalex.org/W1668344921', 'https://openalex.org/W1872376120', 'https://openalex.org/W1903414318', 'https://openalex.org/W1940519961', 'https://openalex.org/W1948919957', 'https://openalex.org/W1959223184', 'https://openalex.org/W1960735897', 'https://openalex.org/W1963676049', 'https://openalex.org/W1964784067', 'https://openalex.org/W1966822199', 'https://openalex.org/W1978793403', 'https://openalex.org/W1985655958', 'https://openalex.org/W1988849173', 'https://openalex.org/W1991327515', 'https://openalex.org/W1996771841', 'https://openalex.org/W2008874237', 'https://openalex.org/W2017887810', 'https://openalex.org/W2020935865', 'https://openalex.org/W2027426714', 'https://openalex.org/W2029807159', 'https://openalex.org/W2033068332', 'https://openalex.org/W2037939651', 'https://openalex.org/W2039096622', 'https://openalex.org/W2042733026', 'https://openalex.org/W2053712580', 'https://openalex.org/W2057329643', 'https://openalex.org/W2058742494', 'https://openalex.org/W2059248106', 'https://openalex.org/W2061773268', 'https://openalex.org/W2069523418', 'https://openalex.org/W2073864172', 'https://openalex.org/W2075691498', 'https://openalex.org/W2076359142', 'https://openalex.org/W2083651501', 'https://openalex.org/W2084450708', 'https://openalex.org/W2088866343', 'https://openalex.org/W2095410649', 'https://openalex.org/W2096386031', 'https://openalex.org/W2097336990', 'https://openalex.org/W2098099120', 'https://openalex.org/W2100286113', 'https://openalex.org/W2106392233', 'https://openalex.org/W2107768418', 'https://openalex.org/W2110289399', 'https://openalex.org/W2115637560', 'https://openalex.org/W2120003285', 'https://openalex.org/W2124750535', 'https://openalex.org/W2124976615', 'https://openalex.org/W2131564994', 'https://openalex.org/W2132380031', 'https://openalex.org/W2134992080', 'https://openalex.org/W2135522980', 'https://openalex.org/W2138384626', 'https://openalex.org/W2144475886', 'https://openalex.org/W2145434557', 'https://openalex.org/W2156715212', 'https://openalex.org/W2158660540', 'https://openalex.org/W2999527130', 'https://openalex.org/W4234012592', 'https://openalex.org/W4251091760', 'https://openalex.org/W4297819239', 'https://openalex.org/W4318470708', 'https://openalex.org/W69871636'], 'related_works': ['https://openalex.org/W4253737590', 'https://openalex.org/W4229061875', 'https://openalex.org/W3151746898', 'https://openalex.org/W2624190431', 'https://openalex.org/W2586253893', 'https://openalex.org/W2357993352', 'https://openalex.org/W2158695265', 'https://openalex.org/W2100640924', 'https://openalex.org/W2029435936', 'https://openalex.org/W1998275064'], 'abstract_inverted_index': {'Mutations': [0], 'in': [1, 55, 99, 127, 143, 171], 'the': [2, 6, 70, 73, 80, 100, 158, 211, 226, 236, 244, 250], 'gene': [3], 'coding': [4], 'for': [5, 69, 235, 243], 'ubiquitous,': [7], 'anti-oxidant': [8], 'enzyme': [9], 'Cu,Zn': [10], 'superoxide': [11], 'dismutase': [12], '(SOD1)': [13], 'are': [14, 164, 209], 'associated': [15], 'with': [16, 154, 194], 'familial': [17], 'amyotrophic': [18], 'lateral': [19], 'sclerosis': [20], '(fALS),': [21], 'a': [22, 34, 52, 60, 84, 222], 'fatal': [23], 'disease': [24], 'characterized': [25], 'by': [26, 175, 192, 198], 'selective': [27, 179], 'loss': [28], 'of': [29, 33, 38, 72, 83, 102, 117, 120, 124, 136, 168, 181, 200, 238, 249, 254, 259], 'motor': [30, 44, 184], 'neurons.': [31], 'Expression': [32], 'mutant': [35, 94, 160], 'SOD1': [36], 'typical': [37], 'fALS': [39, 93, 240], 'patients': [40], 'restricted': [41], 'to': [42, 50, 166], 'either': [43], 'neurons': [45, 185], 'or': [46], 'astrocytes': [47], 'is': [48, 67, 140, 190], 'insufficient': [49], 'generate': [51, 221], 'pathological': [53], 'phenotype': [54], 'mouse': [56], 'models,': [57], 'suggesting': [58], 'that': [59, 109, 220], 'deleterious': [61], 'interplay': [62, 224], 'between': [63, 87, 215, 225], 'different': [64], 'cell': [65, 228], 'types': [66], 'necessary': [68], 'pathogenesis': [71, 237], 'disease.': [74], 'In': [75], 'this': [76], 'study,': [77], 'we': [78], 'demonstrate': [79], 'actual': [81], 'role': [82], 'functional': [85, 223], 'cross-talk': [86, 231], 'glial': [88, 216, 260], 'and': [89, 122, 138, 151, 196, 206, 217, 258], 'neuronal': [90, 218], 'cells': [91, 112, 131, 173, 219], 'expressing': [92, 113, 133, 146, 157], 'G93A-SOD1,': [95], 'where': [96, 252], 'an': [97], 'increase': [98], 'production': [101], 'reactive': [103], 'oxygen': [104], 'species': [105], 'occurs.': [106], 'We': [107], 'show': [108], 'human': [110, 129], 'glioblastoma': [111, 155], 'G93A-SOD1': [114, 187], 'induce': [115], 'activation': [116, 123, 167, 261], 'caspase-1,': [118], 'release': [119], 'cytokines,': [121, 204], 'apoptotic': [125], 'pathways': [126], 'cocultured': [128, 153, 176], 'neuroblastoma': [130, 144], 'also': [132, 142, 242], 'G93A-SOD1.': [134], 'Activation': [135], 'caspase-1': [137], 'caspase-3': [139], 'observed': [141], 'lines': [145, 156], 'other': [147], 'fALS-SOD1s': [148], '(G37R,': [149], 'G85R,': [150], 'I113T)': [152], 'corresponding': [159], 'enzymes.': [161], 'These': [162], 'effects': [163], 'consequent': [165], 'inflammatory': [169], 'processes': [170], 'G93A-glioblastoma': [172, 195], 'stimulated': [174], 'G93A-neuroblastoma.': [177], 'Furthermore,': [178], 'death': [180], 'embryonal': [182], 'spinal': [183], 'from': [186], 'transgenic': [188], 'mice': [189], 'induced': [191], 'coculture': [193], 'prevented': [197], 'inhibition': [199], 'NO': [201], 'synthase.': [202], 'Proinflammatory': [203], 'interferon-gamma,': [205], 'nitric': [207], 'oxide': [208], 'among': [210], 'molecular': [212], 'signals': [213], 'exchanged': [214], 'two': [227], 'types.': [229], 'This': [230], 'may': [232], 'be': [233], 'crucial': [234], 'SOD1-linked': [239], 'but': [241], 'more': [245], 'common': [246], 'sporadic': [247], 'form': [248], 'disease,': [251], 'markers': [253], 'increased': [255], 'oxidative': [256], 'stress': [257], 'have': [262], 'been': [263], 'found.': [264]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2153584160', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-14T06:55:29.993867', 'created_date': '2016-06-24'}