Publication Information

{'id': 'https://openalex.org/W2153554964', 'doi': 'https://doi.org/10.1002/pros.21374', 'title': 'VAT‐1 is a novel pathogenic factor of progressive benign prostatic hyperplasia', 'display_name': 'VAT‐1 is a novel pathogenic factor of progressive benign prostatic hyperplasia', 'publication_year': 2011, 'publication_date': '2011-03-10', 'ids': {'openalex': 'https://openalex.org/W2153554964', 'doi': 'https://doi.org/10.1002/pros.21374', 'mag': '2153554964', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21394740'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/pros.21374', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S197000376', 'display_name': 'The Prostate', 'issn_l': '0270-4137', 'issn': ['0270-4137', '1097-0045'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040152969', 'display_name': 'Fumitaka Mori', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150240954', 'display_name': 'University of Shizuoka', 'ror': 'https://ror.org/04rvw0k47', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I150240954']}, {'id': 'https://openalex.org/I4210120269', 'display_name': 'Taiho Pharmaceutical (Japan)', 'ror': 'https://ror.org/02v50dx14', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210120269']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Fumitaka Mori', 'raw_affiliation_strings': ['Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan', 'Drug Discovery Research Center, Taiho Pharmaceutical Co., Ltd, Ibaraki, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan', 'institution_ids': ['https://openalex.org/I150240954']}, {'raw_affiliation_string': 'Drug Discovery Research Center, Taiho Pharmaceutical Co., Ltd, Ibaraki, Japan', 'institution_ids': ['https://openalex.org/I4210120269']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049862333', 'display_name': 'Kiyoshi Tanigawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210120269', 'display_name': 'Taiho Pharmaceutical (Japan)', 'ror': 'https://ror.org/02v50dx14', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210120269']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kiyoshi Tanigawa', 'raw_affiliation_strings': ['Drug Discovery Research Center, Taiho Pharmaceutical Co., Ltd, Ibaraki, Japan'], 'affiliations': [{'raw_affiliation_string': 'Drug Discovery Research Center, Taiho Pharmaceutical Co., Ltd, Ibaraki, Japan', 'institution_ids': ['https://openalex.org/I4210120269']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086072651', 'display_name': 'Kanji Endo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210120269', 'display_name': 'Taiho Pharmaceutical (Japan)', 'ror': 'https://ror.org/02v50dx14', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210120269']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kanji Endo', 'raw_affiliation_strings': ['Drug Discovery Research Center, Taiho Pharmaceutical Co., Ltd, Ibaraki, Japan'], 'affiliations': [{'raw_affiliation_string': 'Drug Discovery Research Center, Taiho Pharmaceutical Co., Ltd, Ibaraki, Japan', 'institution_ids': ['https://openalex.org/I4210120269']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083062503', 'display_name': 'Kazuhisa Minamiguchi', 'orcid': 'https://orcid.org/0009-0007-6801-6614'}, 'institutions': [{'id': 'https://openalex.org/I4210120269', 'display_name': 'Taiho Pharmaceutical (Japan)', 'ror': 'https://ror.org/02v50dx14', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210120269']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuhisa Minamiguchi', 'raw_affiliation_strings': ['Drug Discovery Research Center, Taiho Pharmaceutical Co., Ltd, Ibaraki, Japan'], 'affiliations': [{'raw_affiliation_string': 'Drug Discovery Research Center, Taiho Pharmaceutical Co., Ltd, Ibaraki, Japan', 'institution_ids': ['https://openalex.org/I4210120269']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054986463', 'display_name': 'Masaaki Abe', 'orcid': 'https://orcid.org/0000-0002-5767-7245'}, 'institutions': [{'id': 'https://openalex.org/I4210120269', 'display_name': 'Taiho Pharmaceutical (Japan)', 'ror': 'https://ror.org/02v50dx14', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210120269']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masaaki Abe', 'raw_affiliation_strings': ['Drug Discovery Research Center, Taiho Pharmaceutical Co., Ltd, Ibaraki, Japan'], 'affiliations': [{'raw_affiliation_string': 'Drug Discovery Research Center, Taiho Pharmaceutical Co., Ltd, Ibaraki, Japan', 'institution_ids': ['https://openalex.org/I4210120269']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051609821', 'display_name': 'Shizuo Yamada', 'orcid': 'https://orcid.org/0000-0002-5915-9863'}, 'institutions': [{'id': 'https://openalex.org/I150240954', 'display_name': 'University of Shizuoka', 'ror': 'https://ror.org/04rvw0k47', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I150240954']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shizuo Yamada', 'raw_affiliation_strings': ['Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan', 'institution_ids': ['https://openalex.org/I150240954']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112580086', 'display_name': 'Kazuhisa Miyoshi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210120269', 'display_name': 'Taiho Pharmaceutical (Japan)', 'ror': 'https://ror.org/02v50dx14', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210120269']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuhisa Miyoshi', 'raw_affiliation_strings': ['Drug Discovery Research Center, Taiho Pharmaceutical Co., Ltd, Ibaraki, Japan'], 'affiliations': [{'raw_affiliation_string': 'Drug Discovery Research Center, Taiho Pharmaceutical Co., Ltd, Ibaraki, Japan', 'institution_ids': ['https://openalex.org/I4210120269']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5040152969'], 'corresponding_institution_ids': ['https://openalex.org/I150240954', 'https://openalex.org/I4210120269'], 'apc_list': {'value': 4380, 'currency': 'USD', 'value_usd': 4380, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.286, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 9, 'citation_normalized_percentile': {'value': 0.695615, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '71', 'issue': '14', 'first_page': '1579', 'last_page': '1586'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10279', 'display_name': 'Urinary Bladder and Prostate Research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2748', 'display_name': 'Urology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10279', 'display_name': 'Urinary Bladder and Prostate Research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2748', 'display_name': 'Urology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11815', 'display_name': 'Urological Disorders and Treatments', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/2748', 'display_name': 'Urology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12695', 'display_name': 'Urinary and Genital Oncology Studies', 'score': 0.9886, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/du145', 'display_name': 'DU145', 'score': 0.6435413}], 'concepts': [{'id': 'https://openalex.org/C16930146', 'wikidata': 'https://www.wikidata.org/wiki/Q4381253', 'display_name': 'Stromal cell', 'level': 2, 'score': 0.73795617}, {'id': 'https://openalex.org/C2777562237', 'wikidata': 'https://www.wikidata.org/wiki/Q835051', 'display_name': 'Hyperplasia', 'level': 2, 'score': 0.6976576}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.6524339}, {'id': 'https://openalex.org/C2776438761', 'wikidata': 'https://www.wikidata.org/wiki/Q5206280', 'display_name': 'DU145', 'level': 5, 'score': 0.6435413}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.57884604}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.56351894}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5258782}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5128927}, {'id': 'https://openalex.org/C2779478474', 'wikidata': 'https://www.wikidata.org/wiki/Q446372', 'display_name': 'Lower urinary tract symptoms', 'level': 4, 'score': 0.5096741}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37249655}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.33977157}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.32362324}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.24524054}, {'id': 'https://openalex.org/C2779723316', 'wikidata': 'https://www.wikidata.org/wiki/Q6459234', 'display_name': 'LNCaP', 'level': 4, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/pros.21374', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S197000376', 'display_name': 'The Prostate', 'issn_l': '0270-4137', 'issn': ['0270-4137', '1097-0045'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.79, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 26, 'referenced_works': ['https://openalex.org/W1508395055', 'https://openalex.org/W1794017546', 'https://openalex.org/W1963947734', 'https://openalex.org/W1969256622', 'https://openalex.org/W1978879981', 'https://openalex.org/W1980122321', 'https://openalex.org/W1983502543', 'https://openalex.org/W198934061', 'https://openalex.org/W1993339135', 'https://openalex.org/W2003781668', 'https://openalex.org/W2005010706', 'https://openalex.org/W2013608315', 'https://openalex.org/W2031167955', 'https://openalex.org/W2033836742', 'https://openalex.org/W2050574267', 'https://openalex.org/W2051592657', 'https://openalex.org/W2055816169', 'https://openalex.org/W2069404601', 'https://openalex.org/W2077297130', 'https://openalex.org/W2091362934', 'https://openalex.org/W2094143658', 'https://openalex.org/W2095297778', 'https://openalex.org/W2100609181', 'https://openalex.org/W2154339406', 'https://openalex.org/W2400783631', 'https://openalex.org/W2416107013'], 'related_works': ['https://openalex.org/W2809321399', 'https://openalex.org/W2462851122', 'https://openalex.org/W2413880872', 'https://openalex.org/W2400783631', 'https://openalex.org/W2389718753', 'https://openalex.org/W2377899455', 'https://openalex.org/W2371422341', 'https://openalex.org/W2354209970', 'https://openalex.org/W2069404601', 'https://openalex.org/W2030021613'], 'abstract_inverted_index': {'Abstract': [0], 'BACKGROUND': [1], 'Benign': [2], 'prostatic': [3, 8, 60], 'hyperplasia': [4, 10], '(BPH),': [5], 'arising': [6], 'from': [7], 'stromal': [9, 155, 195], '(STH),': [11], 'is': [12, 33, 50, 239], 'a': [13, 44, 65, 92, 159, 175, 240], 'progressive': [14], 'disease': [15], 'associated': [16, 246], 'with': [17, 247], 'bothersome': [18], 'lower': [19], 'urinary': [20], 'tract': [21], 'symptoms': [22], '(LUTS).': [23], 'The': [24, 101, 119], 'mechanism': [25], 'of': [26, 112, 138, 152, 179, 197, 213], 'this': [27], 'STH': [28, 54, 56, 61, 73, 86, 146, 231], 'remains': [29], 'unclear': [30], 'because': [31], 'there': [32], 'no': [34], 'suitable': [35], 'model': [36, 48, 87, 147], 'to': [37, 53, 68, 108], 'study': [38], 'BPH': [39, 47, 202, 245], 'pathology.': [40], 'Previously,': [41], 'we': [42, 63, 235], 'reported': [43], 'new': [45], 'experimental': [46], 'that': [49, 184, 237], 'clinically': [51], 'relevant': [52], '(the': [55], 'model).': [57], 'To': [58], 'elucidate': [59], 'mechanism,': [62], 'used': [64, 107], 'compound': [66, 83], 'found': [67], 'be': [69], 'effective': [70, 82], 'in': [71, 84, 116, 123, 144, 158, 191, 205, 229, 244], 'the': [72, 81, 85, 110, 113, 124, 145, 150, 185, 230], 'model.': [74, 232], 'METHODS': [75], 'A': [76, 131], 'binding': [77, 114, 120, 177], 'protein': [78, 115, 121, 178], 'specific': [79, 176], 'for': [80], 'was': [88, 106, 126, 172, 189], 'pulled': [89], 'down': [90], 'using': [91], 'compound‐conjugated': [93], 'affinity': [94], 'matrix': [95], 'and': [96, 148, 194, 200, 222, 224], 'identified': [97, 173], 'by': [98, 128], 'mass': [99], 'spectrometry.': [100], 'RNA': [102], 'interference': [103], '(RNAi)': [104], 'method': [105], 'confirm': [109], 'participation': [111], 'cell': [117, 219, 248], 'proliferation.': [118, 249], 'expression': [122, 187], 'prostate': [125, 154, 217], 'assessed': [127], 'immunohistochemistry.': [129], 'RESULTS': [130], 'benzimidazole': [132], 'derivative': [133], '(Benz)': [134], 'significantly': [135], 'suppressed': [136, 225], 'growth': [137, 227], 'implanted': [139], 'urogenital': [140], 'sinuses': [141], '(UGS;': [142], '37.1%)': [143], 'inhibited': [149, 211], 'proliferation': [151, 212], 'human': [153, 201], 'cells': [156, 196], '(PrSC)': [157], 'concentration‐dependent': [160], 'manner': [161], '(IC': [162], '50': [163], '=': [164], '0.43': [165], 'µM).': [166], 'Vesicle': [167], 'amine': [168], 'transport': [169], 'protein‐1': [170], '(VAT‐1)': [171], 'as': [174], 'Benz.': [180], 'Immunohistochemical': [181], 'analysis': [182], 'showed': [183], 'VAT‐1': [186, 208, 238], 'level': [188], 'higher': [190], 'both': [192], 'epithelial': [193], 'rat': [198], 'UGS': [199, 226], 'tissue': [203], 'than': [204], 'normal': [206], 'prostate.': [207], 'siRNA': [209], 'markedly': [210], 'PrSC,': [214], 'two': [215], 'androgen‐independent': [216], 'cancer': [218], 'lines': [220], '(PC3': [221], 'DU145),': [223], '(28.2%)': [228], 'CONCLUSIONS': [233], 'Here,': [234], 'demonstrate': [236], 'novel': [241], 'pathogenic': [242], 'factor': [243], 'Prostate': [250], '71:1579–1586,': [251], '2011.': [252], '©': [253], '2011': [254], 'Wiley‐Liss,': [255], 'Inc.': [256]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2153554964', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-12T13:47:03.371355', 'created_date': '2016-06-24'}