Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2153351514', 'doi': 'https://doi.org/10.1111/j.1749-6632.1993.tb17195.x', 'title': 'Growth Suppression of Normal Mammary Epithelial Cells by Wild‐Type <i>p53</i>', 'display_name': 'Growth Suppression of Normal Mammary Epithelial Cells by Wild‐Type <i>p53</i>', 'publication_year': 1993, 'publication_date': '1993-11-01', 'ids': {'openalex': 'https://openalex.org/W2153351514', 'doi': 'https://doi.org/10.1111/j.1749-6632.1993.tb17195.x', 'mag': '2153351514', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8279747'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1749-6632.1993.tb17195.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S8802318', 'display_name': 'Annals of the New York Academy of Sciences', 'issn_l': '0077-8923', 'issn': ['0077-8923', '1749-6632'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042622817', 'display_name': 'Giorgio R. Merlo', 'orcid': 'https://orcid.org/0000-0002-6478-0486'}, 'institutions': [{'id': 'https://openalex.org/I860889466', 'display_name': 'Friedrich Miescher Institute', 'ror': 'https://ror.org/01bmjkv45', 'country_code': 'CH', 'type': 'facility', 'lineage': ['https://openalex.org/I860889466']}], 'countries': ['CH'], 'is_corresponding': True, 'raw_author_name': 'GIORGIO R. MERLO', 'raw_affiliation_strings': ['Friedrich Miescher Institute P.O. Box 2543 CH 4002 Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Friedrich Miescher Institute P.O. Box 2543 CH 4002 Basel, Switzerland', 'institution_ids': ['https://openalex.org/I860889466']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015518183', 'display_name': 'Tiziana Venesio', 'orcid': 'https://orcid.org/0000-0002-9035-056X'}, 'institutions': [{'id': 'https://openalex.org/I4210119509', 'display_name': 'Ospedale San Giovanni Bosco', 'ror': 'https://ror.org/0300pwe30', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210119509']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'TIZIANA VENESIO', 'raw_affiliation_strings': ['S. Giovanni Hospital USL-1 10123 Torino, Italy'], 'affiliations': [{'raw_affiliation_string': 'S. Giovanni Hospital USL-1 10123 Torino, Italy', 'institution_ids': ['https://openalex.org/I4210119509']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012376450', 'display_name': 'Daniela Taverna', 'orcid': 'https://orcid.org/0000-0002-6365-527X'}, 'institutions': [{'id': 'https://openalex.org/I860889466', 'display_name': 'Friedrich Miescher Institute', 'ror': 'https://ror.org/01bmjkv45', 'country_code': 'CH', 'type': 'facility', 'lineage': ['https://openalex.org/I860889466']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'DANIELA TAVERNA', 'raw_affiliation_strings': ['Friedrich Miescher Institute P.O. Box 2543 CH 4002 Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Friedrich Miescher Institute P.O. Box 2543 CH 4002 Basel, Switzerland', 'institution_ids': ['https://openalex.org/I860889466']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062531292', 'display_name': 'Robert Callahan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'ROBERT CALLAHAN', 'raw_affiliation_strings': ['Oncogenetics Section National Cancer Institute Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'Oncogenetics Section National Cancer Institute Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I4210140884']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5023604575', 'display_name': 'Nancy E. Hynes', 'orcid': 'https://orcid.org/0000-0001-8802-2316'}, 'institutions': [{'id': 'https://openalex.org/I860889466', 'display_name': 'Friedrich Miescher Institute', 'ror': 'https://ror.org/01bmjkv45', 'country_code': 'CH', 'type': 'facility', 'lineage': ['https://openalex.org/I860889466']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'NANCY E. HYNES', 'raw_affiliation_strings': ['Friedrich Miescher Institute P.O. Box 2543 CH 4002 Basel, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Friedrich Miescher Institute P.O. Box 2543 CH 4002 Basel, Switzerland', 'institution_ids': ['https://openalex.org/I860889466']}]}], 'countries_distinct_count': 3, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5042622817'], 'corresponding_institution_ids': ['https://openalex.org/I860889466'], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.579006, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 78, 'max': 79}, 'biblio': {'volume': '698', 'issue': '1', 'first_page': '108', 'last_page': '113'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12996', 'display_name': 'Engineering Bacteria for Cancer Treatment', 'score': 0.9917, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Stem Cells and Tumor Metastasis', 'score': 0.9901, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/wild-type', 'display_name': 'Wild type', 'score': 0.5940203}, {'id': 'https://openalex.org/keywords/p53', 'display_name': 'p53', 'score': 0.557456}, {'id': 'https://openalex.org/keywords/splice', 'display_name': 'splice', 'score': 0.49549592}], 'concepts': [{'id': 'https://openalex.org/C207583985', 'wikidata': 'https://www.wikidata.org/wiki/Q128723', 'display_name': 'Wild type', 'level': 4, 'score': 0.5940203}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.5852625}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.57884413}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5431416}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.52593213}, {'id': 'https://openalex.org/C2780989783', 'wikidata': 'https://www.wikidata.org/wiki/Q7578557', 'display_name': 'splice', 'level': 3, 'score': 0.49549592}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4091611}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.40026394}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3458335}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.19660515}], 'mesh': [{'descriptor_ui': 'D019187', 'descriptor_name': 'Cadmium Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D016158', 'descriptor_name': 'Genes, p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008321', 'descriptor_name': 'Mammary Glands, Animal', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D013431', 'descriptor_name': 'Sulfates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002104', 'descriptor_name': 'Cadmium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002104', 'descriptor_name': 'Cadmium', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003062', 'descriptor_name': 'Codon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005091', 'descriptor_name': 'Exons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008321', 'descriptor_name': 'Mammary Glands, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017354', 'descriptor_name': 'Point Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012377', 'descriptor_name': 'Rodentia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017384', 'descriptor_name': 'Sequence Deletion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1749-6632.1993.tb17195.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S8802318', 'display_name': 'Annals of the New York Academy of Sciences', 'issn_l': '0077-8923', 'issn': ['0077-8923', '1749-6632'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8279747', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W103115627', 'https://openalex.org/W1507475205', 'https://openalex.org/W1601520142', 'https://openalex.org/W1655441320', 'https://openalex.org/W1922148398', 'https://openalex.org/W1977686001', 'https://openalex.org/W1989587903', 'https://openalex.org/W2004144304', 'https://openalex.org/W2008301561', 'https://openalex.org/W2010344294', 'https://openalex.org/W2012053348', 'https://openalex.org/W2025348241', 'https://openalex.org/W2039867621', 'https://openalex.org/W2051807285', 'https://openalex.org/W2090025028', 'https://openalex.org/W2098567881', 'https://openalex.org/W2126679757', 'https://openalex.org/W2128060680', 'https://openalex.org/W2130153603', 'https://openalex.org/W2131675463', 'https://openalex.org/W2150097377', 'https://openalex.org/W2163565167', 'https://openalex.org/W2413828262', 'https://openalex.org/W61326834'], 'related_works': ['https://openalex.org/W4243536880', 'https://openalex.org/W2274928342', 'https://openalex.org/W2159668471', 'https://openalex.org/W2146027704', 'https://openalex.org/W2134451695', 'https://openalex.org/W2032059901', 'https://openalex.org/W2029220916', 'https://openalex.org/W2008389025', 'https://openalex.org/W1552032432', 'https://openalex.org/W1505791290'], 'abstract_inverted_index': {'We': [0], 'examined': [1], 'the': [2, 5, 9, 39, 64, 72], 'status': [3], 'of': [4, 30, 38, 56, 66, 74], 'p53': [6, 51], 'gene': [7], 'in': [8, 61], 'HC11': [10], 'normal': [11], 'mammary': [12, 75], 'epithelial': [13], 'cells.': [14, 76], 'Two': [15], 'mutations': [16, 45], 'were': [17, 46], 'identified:': [18], 'a': [19, 28], 'Cys': [20], 'to': [21, 33], 'Trp': [22], 'change': [23], 'at': [24], 'codon': [25, 31], '138': [26], 'and': [27, 48], 'microdeletion': [29], '123': [32], '130': [34], 'resulting': [35], 'from': [36], 'mutation': [37], 'splice': [40], 'acceptor': [41], 'site.': [42], 'These': [43], 'two': [44], 'independent,': [47], 'no': [49], 'wild-type': [50], 'allele': [52], 'was': [53], 'found.': [54], 'Introduction': [55], 'wt-p53': [57, 67], 'strongly': [58], 'inhibited': [59], 'growth': [60], 'monolayer.': [62], 'Thus,': [63], 'absence': [65], 'can': [68], 'be': [69], 'sufficient': [70], 'for': [71], 'immortalization': [73]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2153351514', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-08-31T15:08:35.948682', 'created_date': '2016-06-24'}