Publication Information

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'https://openalex.org/W2119487442', 'https://openalex.org/W2131065520', 'https://openalex.org/W2137318731', 'https://openalex.org/W2139362624', 'https://openalex.org/W2141430946', 'https://openalex.org/W2143001233', 'https://openalex.org/W2155863144', 'https://openalex.org/W2158818470', 'https://openalex.org/W2162051767', 'https://openalex.org/W2164979127', 'https://openalex.org/W2169152986'], 'related_works': ['https://openalex.org/W91867460', 'https://openalex.org/W4321459347', 'https://openalex.org/W2985227704', 'https://openalex.org/W2550012727', 'https://openalex.org/W2164253947', 'https://openalex.org/W2083045229', 'https://openalex.org/W2044728544', 'https://openalex.org/W2016203088', 'https://openalex.org/W1998704269', 'https://openalex.org/W1991783911'], 'abstract_inverted_index': {'Accumulation': [0, 222], 'of': [1, 28, 32, 45, 88, 92, 98, 106, 118, 131, 138, 194, 211, 223, 250, 254, 267, 310, 314, 320, 328, 340, 353, 360, 416, 433, 451, 511, 557, 561, 566, 901, 960, 968, 981, 990, 1305, 1317, 1332, 1361, 1388, 1403, 1436, 1490, 1566, 1630, 1636, 1643, 1659, 1665, 1668, 2051, 2062, 2159, 2297, 2317, 2344, 2351, 2386, 2404, 2488, 2494, 2717, 2720, 2793, 2890, 2901, 2933, 2954, 3041, 3147, 3160, 3184, 3193, 3231, 3327, 3408, 3417, 3475, 3480, 3514, 3528, 3535, 3630, 3654, 3668, 3679, 3688, 3699, 3706, 3744, 3773, 3782, 3807, 3815, 3851, 3864, 3875, 3901, 3938, 3999, 4128, 4293, 4300, 4318, 4350, 4412, 4494], 'extracellular': [2, 224], 'amyloid': [3, 9, 225, 231, 453, 462, 466], 'β': [4, 226, 467], 'peptide': [5, 227, 1355], '(Aβ),': [6, 228], 'generated': [7, 229, 2335], 'from': [8, 34, 230, 256, 650, 1407, 1419, 1472, 1498, 2080, 2328, 2389, 2506, 2643, 3060, 3207, 3672, 3927, 4140, 4146, 4377], 'precursor': [10, 232, 454, 463], 'protein': [11, 202, 233, 424, 455, 606, 1278, 1323, 1371, 1841, 2161, 2364, 2388, 2499, 2503, 3103, 3893, 4032, 4275], '(APP)': [12, 234, 456], 'processing': [13, 189, 219, 235, 411, 441, 450, 547, 643, 731, 802, 869, 909, 1286, 1340, 3399, 3564, 3766], 'by': [14, 39, 236, 261, 553, 646, 944, 956, 987, 1027, 1311, 1561, 1612, 1625, 1654, 1679, 1692, 2077, 2170, 2212, 2239, 2255, 2464, 2492, 2509, 2520, 2589, 2688, 2888, 3071, 3137, 3521, 3638, 3649, 3683, 3693, 3712, 3769, 4114, 4285], 'β-': [15, 237, 567, 949], 'and': [16, 22, 43, 85, 94, 140, 162, 180, 188, 218, 238, 244, 265, 307, 316, 362, 384, 402, 410, 440, 568, 587, 598, 612, 714, 726, 730, 870, 908, 939, 950, 1169, 1260, 1281, 1285, 1339, 1344, 1374, 1379, 1391, 1394, 1409, 1433, 1483, 1540, 1554, 1647, 1662, 1709, 1761, 1783, 1829, 1864, 1871, 1889, 1926, 1930, 1963, 1981, 1986, 1992, 2006, 2045, 2064, 2141, 2144, 2229, 2271, 2379, 2400, 2447, 2474, 2518, 2533, 2547, 2581, 2606, 2620, 2654, 2669, 2674, 2775, 2787, 2825, 2847, 2875, 2904, 2924, 2963, 3067, 3130, 3218, 3242, 3281, 3314, 3333, 3349, 3398, 3489, 3511, 3516, 3524, 3565, 3576, 3585, 3627, 3633, 3641, 3883, 3997, 4018, 4036, 4107, 4158, 4202, 4226, 4246, 4305, 4330, 4343, 4356, 4371, 4381, 4403, 4414, 4416, 4490], 'γ-secretases,': [17, 239], 'is': [18, 23, 36, 240, 245, 258, 506, 550, 962, 978, 1070, 2984, 3099, 3116, 3173, 3187, 3252, 3262, 3273, 3465, 3869, 3990, 4004, 4007, 4027, 4034, 4043, 4084, 4123, 4241, 4314, 4345], 'toxic': [19, 241], 'to': [20, 25, 63, 77, 126, 157, 190, 220, 242, 247, 285, 299, 348, 379, 412, 442, 508, 548, 594, 644, 717, 732, 799, 803, 866, 910, 1021, 1024, 1072, 1160, 1261, 1287, 1341, 1357, 1766, 1768, 1843, 1866, 1965, 1988, 2026, 2067, 2156, 2232, 2361, 2381, 2601, 2615, 2822, 2835, 2927, 2967, 2988, 2999, 3043, 3090, 3092, 3128, 3133, 3167, 3198, 3258, 3342, 3400, 3792, 3860, 3890, 3915, 3952, 4010, 4045, 4401, 4408], 'neurons': [21, 206, 243, 428, 4317, 4365], 'central': [24, 246, 507], 'the': [26, 40, 64, 69, 127, 143, 158, 167, 209, 212, 248, 262, 286, 291, 349, 365, 380, 389, 431, 434, 452, 509, 554, 562, 718, 722, 899, 954, 966, 982, 988, 1172, 1333, 1358, 1389, 1395, 1487, 1506, 1547, 1609, 1613, 1639, 1648, 1674, 1683, 1700, 1786, 2024, 2032, 2048, 2073, 2129, 2157, 2295, 2337, 2495, 2507, 2823, 2841, 2848, 2862, 2883, 2934, 2940, 2948, 2968, 2973, 3039, 3045, 3051, 3082, 3109, 3113, 3148, 3157, 3161, 3181, 3190, 3200, 3232, 3238, 3243, 3249, 3265, 3269, 3277, 3317, 3324, 3409, 3413, 3473, 3532, 3628, 3669, 3686, 3697, 3702, 3726, 3742, 3755, 3764, 3771, 3802, 3811, 3873, 3899, 3936, 3978, 3993, 4039, 4046, 4120, 4125, 4134, 4141, 4147, 4150, 4169, 4179, 4207, 4274, 4301, 4319, 4375, 4409, 4491], 'pathogenesis': [27, 249, 510], 'Alzheimer': [29, 251, 474, 512], 'disease.': [30, 252], 'Production': [31, 253], 'Aβ': [33, 113, 255, 335, 549, 613, 645, 733, 804, 871, 911, 942, 1404, 2016, 2071, 2127, 2152, 3334, 3517, 3549, 3566, 3578, 3634, 3966], 'APP': [35, 65, 107, 122, 141, 164, 185, 199, 215, 257, 287, 329, 344, 363, 386, 407, 421, 437, 546, 597, 610, 642, 648, 723, 801, 868, 906, 946, 961, 1280, 1295, 1306, 1325, 1337, 1437, 1618, 1675, 1805, 2249, 2270, 2969, 2976, 3046, 3053, 3114, 3162, 3244, 3321, 3331, 3395, 3487, 3515, 3536, 3563, 3575, 3632, 3655, 3680, 3720, 3745, 3765, 3783, 3852, 3865, 3876, 3902, 3939, 4006, 4017, 4083, 4135, 4159, 4194, 4220, 4306, 4357, 4382, 4402, 4405], 'greatly': [37, 259, 551, 3657, 3941], 'affected': [38, 260, 552], 'subcellular': [41, 263, 555, 564, 4170], 'localization': [42, 264, 556, 3192, 3416, 3996], 'trafficking': [44, 187, 217, 266, 409, 439, 729, 907, 947, 959, 1284, 1308, 1338, 3397], 'APP.': [46, 132, 268, 354, 3105, 3259, 4000, 4372], 'Here': [47, 269], 'we': [48, 270, 1269, 3037, 3121, 3385, 3471, 3572], 'have': [49, 271, 543, 591, 3336], 'identified': [50, 272], 'a': [51, 89, 109, 136, 150, 197, 273, 311, 331, 358, 372, 419, 979, 991, 1320, 1329, 1352, 1551, 2010, 2287, 2305, 2527, 2631, 2700, 2709, 2765, 2772, 2830, 2899, 2980, 3100, 3345, 3477, 3861, 4028, 4481], 'novel': [52, 198, 274, 420, 969, 1321, 3101], 'intracellular': [53, 181, 200, 216, 275, 403, 422, 438, 958, 1025, 1276], 'adaptor': [54, 153, 182, 201, 276, 375, 404, 423, 589, 709, 1277, 1313, 1322, 2992], 'protein,': [55, 154, 277, 376], 'sorting': [56, 278, 983, 1067], 'nexin': [57, 279, 975, 984], '17': [58, 280, 976], '(SNX17),': [59, 281], 'that': [60, 72, 149, 176, 282, 294, 371, 398, 448, 545, 933, 1271, 1292, 1302, 2880, 2983, 3097, 3145, 3170, 3248, 3268, 3316, 3339, 3387, 3406, 3676, 3741, 3763, 3778, 3805, 3935, 3965, 3987, 4033, 4136, 4156, 4217, 4238], 'binds': [61, 156, 283, 378, 2998, 3341, 4407], 'specifically': [62, 284], 'cytoplasmic': [66, 288, 588, 724, 1177, 1619, 2977, 3047, 3054, 3245], 'domain': [67, 289, 725, 994, 1641, 1650, 2978, 3055, 3183, 3234, 3251, 3272, 3319, 3326, 3411, 3485], 'via': [68, 290], 'YXNPXY': [70, 160, 292, 382, 2974, 2981, 3158], 'motif': [71, 161, 293, 383, 720, 2982, 3005, 3111, 3127, 3159, 3172, 3348], 'has': [73, 295, 446, 796, 863, 912, 1157, 3403, 4137, 4235, 4269], 'been': [74, 296, 592, 797, 864, 914, 1158, 3404, 4138, 4236, 4271], 'shown': [75, 297, 544, 593, 798, 865, 1159, 3078, 3226, 3337, 3405, 4189, 4237, 4334], 'previously': [76, 298, 1422, 1511, 1713, 2412, 2728, 3338], 'bind': [78, 300, 716, 1767, 3044, 3091], 'several': [79, 301, 1163, 2989], 'cell': [80, 151, 168, 178, 302, 373, 390, 400, 707, 1792, 2069, 2163, 2247, 2259, 2481, 2884, 2891, 2990, 3779, 3812, 3994, 4142, 4218], 'surface': [81, 152, 179, 303, 374, 401, 708, 2248, 2885, 2941, 2991, 3780, 3813, 3995, 4143, 4219], 'adaptors,': [82, 304], 'including': [83, 305, 711, 1167, 4389], 'Fe65': [84, 306, 795], 'X11.': [86, 308], 'Overexpression': [87, 309], 'dominant-negative': [90, 312, 3478, 3981], 'mutant': [91, 313, 1804, 3479], 'SNX17': [93, 100, 119, 139, 195, 315, 322, 341, 361, 417, 1023, 1069, 1156, 1272, 1318, 1362, 1543, 1614, 2165, 2208, 2221, 2236, 2453, 2585, 2965, 2997, 3042, 3093, 3098, 3119, 3134, 3241, 3256, 3270, 3280, 3329, 3340, 3388, 3418, 3481, 3494, 3497, 3560, 3581, 3588, 3645, 3689, 3700, 3708, 3718, 3728, 3733, 3757, 3788, 3808, 3854, 3867, 3880, 3907, 3944, 3971, 3988, 4002, 4014, 4042, 4157, 4201, 4230, 4239, 4267, 4279, 4294, 4313, 4355, 4370, 4380], 'RNA': [95, 115, 317, 337], 'interference': [96, 116, 318, 338], 'knockdown': [97, 117, 319, 339, 3582, 3789, 3806, 3855, 3881, 3908, 3945, 3972], 'endogenous': [99, 321, 4369], 'expression': [101, 323, 2167, 2209, 3646, 3687, 3709, 3721, 3772, 3809, 3868, 4268, 4280], 'both': [102, 177, 324, 399, 937, 4348, 4487], 'reduced': [103, 325, 3658, 3786, 3905, 3942], 'steady-state': [104, 129, 326, 351, 3533], 'levels': [105, 130, 327, 352, 2153, 3513, 3534, 3579, 3629, 3653, 3678, 3705, 3743, 3781, 3814, 3850], 'with': [108, 330, 596, 1029, 1162, 1550, 1781, 1839, 1921, 1936, 1990, 2000, 2023, 2037, 2047, 2134, 2148, 2226, 2257, 2265, 2310, 2356, 2406, 2445, 2456, 2485, 2498, 2538, 2549, 2563, 2575, 2594, 2671, 2690, 2699, 2784, 2854, 2894, 2911, 3058, 3205, 3264, 3506, 3538, 3568, 3660, 3715, 3732, 3754, 3801, 3896, 3977, 4016, 4093, 4097, 4110, 4116, 4198, 4229, 4374, 4486], 'concomitant': [110, 332], 'increase': [111, 333], 'in': [112, 142, 205, 334, 364, 427, 905, 1175, 1673, 1699, 1741, 1785, 1808, 1846, 1860, 1878, 1917, 1975, 2018, 2053, 2072, 2128, 2162, 2294, 2394, 2466, 2511, 2552, 2630, 2649, 2663, 2676, 2764, 2771, 2790, 2829, 3079, 3196, 3227, 3394, 3501, 3552, 3562, 3580, 3787, 3853, 3879, 3906, 3943, 3970, 4022, 4086, 4149, 4163, 4190, 4206, 4231, 4244, 4281, 4297, 4316, 4335, 4347, 4360, 4386, 4396], 'production.': [114, 336], 'also': [120, 147, 342, 369, 3739, 3776, 3933, 3963, 4195, 4308], 'decreased': [121, 128, 343, 350, 3531, 3682, 3703, 3749], 'half-life,': [123, 345], 'which': [124, 346, 957, 1019, 3186, 3464, 4484], 'led': [125, 347], 'Immunofluorescence': [133, 355, 2534], 'staining': [134, 356, 1435], 'confirmed': [135, 357], 'colocalization': [137, 359], 'early': [144, 366, 1073, 3414, 4047, 4180, 4222], 'endosomes.': [145, 367], 'We': [146, 368, 1289, 3143, 3738, 3775, 3962, 4277], 'showed': [148, 370, 3675, 3934], 'Dab2,': [155, 377, 1638, 1644, 1646], 'same': [159, 381, 1787, 2049, 4208], 'regulates': [163, 385, 1282], 'endocytosis': [165, 387, 611, 2722, 4419], 'at': [166, 388, 1546, 1774, 1852, 2280, 2544, 2558, 2684, 2957, 4103, 4124, 4273], 'surface.': [169, 391], 'Our': [170, 392, 1297], 'results': [171, 393, 3979, 4215, 4376], 'thus': [172, 394], 'provide': [173, 395], 'strong': [174, 396, 1300], 'evidence': [175, 397, 445, 1301], 'proteins': [183, 405, 590, 935, 1696, 1738, 2523, 2993, 4489], 'regulate': [184, 406, 727, 1262], 'endocytic': [186, 408, 1264, 1307, 3396, 4040], 'Aβ.': [191, 221, 413, 443, 1288, 1342, 3401], 'The': [192, 414, 602, 1315, 1382, 1616, 1789, 2029, 2931, 2952], 'identification': [193, 415, 1316], 'as': [196, 418, 1274, 1319, 1509, 1711, 2175, 2410, 2726, 2877, 2947, 3222, 3496, 4339, 4341], 'highly': [203, 425, 4242, 4384], 'expressed': [204, 426, 1740, 4243, 4315, 4346], 'should': [207, 429, 1326], 'facilitate': [208, 430], 'understanding': [210, 432, 1331], 'relationship': [213, 435], 'between': [214, 436, 3240, 3279], 'Mounting': [444], 'demonstrated': [447], 'proteolytic': [449], '4The': [457], 'abbreviations': [458], 'used': [459, 1375, 1429, 2776, 2946], 'are:': [460], 'APP,': [461, 558, 3199, 3707, 4129, 4173, 4344], 'protein;': [464, 480], 'Aβ,': [465], 'peptide;': [468], 'ELISA,': [469, 3525, 3642], 'enzyme-linked': [470, 1476], 'immunosorbent': [471, 1477], 'assay;': [472], 'AD,': [473], 'disease;': [475], 'LRP,': [476], 'low-density': [477, 503, 603], 'lipoprotein': [478, 504, 604], 'receptor-related': [479, 605], 'HA,': [481], 'hemagglutinin;': [482], 'siRNA,': [483], 'small': [484], 'interfering': [485], 'RNA;': [486], 'GST,': [487, 3087], 'glutathione': [488, 1762, 1844], 'S-transferase;': [489], 'PTB,': [490], 'phosphotyrosine-binding': [491, 1640], 'domain;': [492], 'PBS,': [493], 'phosphate-buffered': [494], 'saline;': [495], 'CHO,': [496], 'Chinese': [497], 'hamster': [498], 'ovary;': [499], 'PX,': [500], 'phox;': [501], 'LDLR,': [502], 'receptor.': [505], 'disease': [513], '(AD)': [514], '(1Selkoe': [515], 'D.J.': [516], 'Physiol.': [517], 'Rev.': [518, 1053], '2001;': [519, 783, 921, 4258, 4428], '81:': [520], '741-766Crossref': [521], 'PubMed': [522, 536, 579, 634, 701, 754, 773, 786, 830, 856, 894, 924, 1014, 1043, 1060, 1094, 1120, 1151, 1198, 1224, 1255, 1460, 1534, 1592, 1731, 1756, 1909, 2121, 2203, 2436, 2751, 3032, 3309, 3379, 3438, 3461, 3617, 3843, 4075, 4261, 4431, 4453, 4474, 4526], 'Scopus': [523, 537, 580, 635, 702, 755, 774, 787, 831, 857, 895, 925, 1015, 1044, 1061, 1095, 1121, 1152, 1199, 1225, 1256, 1461, 1535, 1593, 1757, 2122, 2204, 2437, 2752, 3033, 3310, 3380, 3439, 3618, 3844, 4076, 4262, 4432, 4454, 4475, 4527], '(5170)': [524], 'Google': [525, 539, 582, 637, 704, 757, 776, 789, 833, 859, 897, 927, 1017, 1046, 1063, 1097, 1123, 1154, 1201, 1227, 1258, 1463, 1537, 1595, 1732, 1759, 1910, 2124, 2206, 2439, 2754, 3035, 3312, 3382, 3441, 3462, 3620, 3846, 4078, 4264, 4434, 4456, 4477], 'Scholar,': [526, 758, 777, 834, 1047, 1098, 1124, 1202, 1228, 3442, 4435, 4457], '2Zheng': [527], 'H.': [528, 1719, 1897, 2100], 'Koo': [529], 'E.H.': [530], 'Mol.': [531, 574, 767, 1008, 1054, 2430, 3455], 'Neurodegener.': [532, 575], '2006;': [533, 576, 746, 886, 1040], '1:': [534, 577], '5Crossref': [535], '(291)': [538], 'Scholar).': [540, 583, 705, 790, 860, 928, 1064, 1155, 1464, 1538, 1596, 1733, 1911, 2125, 2207, 2440, 2755, 3383, 3847, 4079, 4478], 'Many': [541], 'reports': [542], 'presumably': [559], 'because': [560], 'specific': [563, 1030], 'localizations': [565], 'γ-secretases': [569], '(3Cam': [570], 'J.A.': [571, 616, 781, 919, 4426], 'Bu': [572, 621, 1144, 1248, 1447, 1521, 2196, 2428, 2738, 3025, 3302, 3372, 3610, 3836, 4068, 4464], 'G.': [573, 622, 1145, 1249, 1448, 1522, 1715, 1744, 1893, 2092, 2197, 2429, 2739, 3026, 3303, 3373, 3611, 3837, 4069, 4465], '8Crossref': [578], '(92)': [581], 'Both': [584], 'transmembrane': [585, 4031], 'receptors': [586], 'interact': [595, 1161], 'affect': [599, 800, 867, 941, 3237], 'its': [600, 728, 902, 1283, 2230, 3165, 3468, 3483], 'trafficking.': [601, 1265], '1': [607, 1819, 1825, 2284, 2542, 2592, 2808, 2813, 4101], '(LRP1)': [608], 'increases': [609], 'production': [614, 872, 943, 3518, 3567, 3635, 3967], '(4Cam': [615], 'Zerbinatti': [617], 'C.V.': [618], 'Li': [619, 2417], 'Y.': [620, 838, 878, 1439, 1513, 2418, 2730], 'J.': [623, 655, 663, 680, 762, 819, 845, 883, 1083, 1114, 1116, 1129, 1143, 1147, 1187, 1218, 1220, 1233, 1247, 1251, 1449, 1523, 1586, 1588, 1722, 1752, 1900, 2181, 2195, 2199, 2740, 3010, 3024, 3028, 3287, 3301, 3305, 3357, 3371, 3375, 3427, 3595, 3609, 3613, 3821, 3835, 3839, 4053, 4067, 4071, 4449, 4508, 4515], 'Biol.': [624, 769, 820, 846, 884, 1010, 1056, 1084, 1188, 1450, 1524, 1723, 1901, 2431, 2741, 3428, 3456, 4516], 'Chem.': [625, 821, 847, 885, 1085, 1189, 1451, 1525, 1724, 1902, 2742, 3429, 4517], '2005;': [626, 698, 1148, 1252, 2200, 3029, 3306, 3376, 3614, 3840, 4072, 4471], '280:': [627], '15464-15470Abstract': [628], 'Full': [629, 631, 749, 751, 825, 827, 851, 853, 889, 891, 1089, 1091, 1193, 1195, 1455, 1457, 1529, 1531, 1728, 1906, 2746, 2748, 3433, 3435, 4521, 4523], 'Text': [630, 632, 750, 752, 826, 828, 852, 854, 890, 892, 1090, 1092, 1194, 1196, 1456, 1458, 1530, 1532, 1729, 1907, 2747, 2749, 3434, 3436, 4522, 4524], 'PDF': [633, 753, 829, 855, 893, 1093, 1197, 1459, 1533, 1730, 1908, 2750, 3437, 4525], '(79)': [636], 'Scholar),': [638, 898, 1018, 1760, 3036, 3463], 'whereas': [639, 3547], 'SorLA': [640], 'decreases': [641, 3810], 'shuttling': [647], 'away': [649], 'endosomes': [651, 1074, 4223], '(5Andersen': [652], 'O.M.': [653], 'Reiche': [654], 'Schmidt': [656], 'V.': [657, 1104, 1139, 1208, 1243, 1576, 2191, 3020, 3297, 3367, 3605, 3831, 4063, 4249], 'Gotthardt': [658], 'M.': [659, 1001, 1137, 1241, 2086, 2098, 2189, 3018, 3295, 3365, 3603, 3829, 4061, 4498], 'Spoelgen': [660], 'R.': [661, 676, 2088, 2094, 3444, 3452, 4253, 4461], 'Behlke': [662], 'von': [664], 'Arnim': [665], 'C.A.': [666, 1049], 'Breiderhoff': [667], 'T.': [668, 3446, 4251, 4512], 'Jansen': [669], 'P.': [670, 816, 1127, 1231, 1444, 1518, 2108, 2179, 2423, 2735, 3008, 3285, 3355, 3450, 3593, 3819, 4051], 'Wu': [671], 'X.': [672], 'Bales': [673, 1492], 'K.R.': [674], 'Cappai': [675], 'Masters': [677], 'C.L.': [678], 'Gliemann': [679], 'Mufson': [681], 'E.J.': [682], 'Hyman': [683], 'B.T.': [684], 'Paul': [685], 'S.M.': [686, 779, 917, 4424], 'Nykjaer': [687], 'A.': [688, 697, 2117], 'Willnow': [689], 'T.E.': [690], 'Proc.': [691, 2111], 'Natl.': [692, 2112], 'Acad.': [693, 2113], 'Sci.': [694, 2114], 'U.': [695, 840, 2115], 'S.': [696, 814, 2116], '102:': [699], '13461-13466Crossref': [700], '(495)': [703], 'Several': [706], 'proteins,': [710], 'Fe65,': [712], 'X11,': [713], 'Dab1,': [715], 'NPXY': [719, 1173, 3004, 3347, 4410], 'within': [721, 3112, 3125, 3156, 3323, 4392], '(6Miller': [734], 'C.C.': [735], 'McLoughlin': [736], 'D.M.': [737], 'Lau': [738], 'K.F.': [739], 'Tennant': [740], 'M.E.': [741], 'Rogelj': [742], 'B.': [743, 766, 1102, 1106, 1206, 1210, 1574, 1578], 'Trends': [744], 'Neurosci.': [745], '29:': [747], '280-285Abstract': [748], '(82)': [756], '7Borg': [759], 'J.P.': [760], 'Ooi': [761], 'Levy': [763], 'E.': [764, 1133, 1237, 2185, 3014, 3291, 3361, 3599, 3825, 4057], 'Margolis': [765], 'Cell.': [768, 1009, 2432, 3457], '1996;': [770], '16:': [771], '6229-6241Crossref': [772], '(436)': [775], '8Morris': [778], 'Cooper': [780, 918, 4425], 'Traffic.': [782, 920, 4427, 4470], '2:': [784, 922, 4429], '111-123Crossref': [785, 923, 4430], '(219)': [788, 926, 4433], 'By': [791], 'overexpression': [792], 'or': [793, 1797, 1803, 1944, 2137, 2373, 2449, 2586, 2608, 3050, 3154, 3214, 3492, 3498, 3541, 3587], 'knockdown,': [794], '(9Sabo': [805], 'S.L.': [806], 'Lanier': [807], 'L.M.': [808, 2420, 4447], 'Ikin': [809], 'A.F.': [810], 'Khorkova': [811], 'O.': [812], 'Sahasrabudhe': [813], 'Greengard': [815], 'Buxbaum': [817], 'J.D.': [818], '1999;': [822], '274:': [823], '7952-7957Abstract': [824], '(196)': [832], '10Xie': [835], 'Z.': [836], 'Dong': [837], 'Maeda': [839], 'Xia': [841], 'W.': [842, 1036, 1100, 1135, 1204, 1239, 1572, 2187, 3016, 3293, 3363, 3601, 3827, 4059], 'Tanzi': [843], 'R.E.': [844], '2007;': [848], '282:': [849], '4318-4325Abstract': [850], '(46)': [858], 'Although': [861], 'Dab1': [862], '(11Hoe': [873], 'H.S.': [874], 'Tran': [875], 'T.S.': [876], 'Matsuoka': [877], 'Howell': [879], 'B.W.': [880], 'Rebeck': [881], 'G.W.': [882], '281:': [887, 4259], '35176-35185Abstract': [888], '(137)': [896], 'function': [900, 3561, 3989, 4003], 'homologue': [903], 'Dab2': [904, 1293, 4399, 4479], 'not': [913, 3086, 3236, 3253, 3274, 3760, 3798, 4270], 'studied': [915], '(8Morris': [916, 4423], 'These': [929], 'studies': [930, 2082], 'firmly': [931], 'establish': [932], 'APP-interacting': [934], 'can': [936], 'positively': [938], 'negatively': [940], 'altering': [945], 'through': [948, 1171, 2972, 3001, 3344, 4038, 4420], 'γ-secretase-containing': [951], 'compartments.': [952, 4233], 'Revealing': [953], 'mechanisms': [955, 1335], 'regulated': [963, 1310], 'may': [964, 3389, 3857], 'permit': [965], 'development': [967], 'therapeutic': [970], 'approaches': [971], 'for': [972, 1279, 1324, 1328, 1376, 1430, 1849, 2139, 2220, 2269, 2283, 2320, 2368, 2460, 2470, 2541, 2555, 2584, 2591, 2657, 2681, 2812, 2898, 2986, 3104, 3118, 3175, 3189, 3255, 3276, 3320, 3467, 3992, 4100, 4178, 4368], 'AD.': [973], 'Sorting': [974], '(SNX17)': [977], 'member': [980], 'family': [985, 1165], 'characterized': [986], 'presence': [989], 'phox': [992], '(PX)': [993], '(12Haft': [995], 'C.R.': [996], 'de': [997], 'la': [998], 'Luz': [999], 'Sierra': [1000], 'Barr': [1002], 'V.A.': [1003], 'Haft': [1004], 'D.H.': [1005], 'Taylor': [1006], 'S.I.': [1007], '1998;': [1011], '18:': [1012], '7278-7287Crossref': [1013], '(214)': [1016], 'serves': [1020, 1273], 'localize': [1022], 'vesicles': [1026], 'interacting': [1028], 'phosphatidylinositol': [1031], 'phosphates': [1032], '(13Seet': [1033], 'L.F.': [1034], 'Hong': [1035], 'Biochim.': [1037], 'Biophys.': [1038, 4255], 'Acta.': [1039], '1761:': [1041], '878-896Crossref': [1042], '(163)': [1045], '14Worby': [1048], 'Dixon': [1050], 'J.E.': [1051], 'Nat.': [1052], 'Cell': [1055, 1660, 1835, 1869, 2906], '2002;': [1057, 1117, 1221, 1589, 2433, 4450], '3:': [1058], '919-931Crossref': [1059], '(332)': [1062], 'Like': [1065], 'many': [1066], 'nexins,': [1068], 'localized': [1071, 4044, 4205], '(15Burden': [1075, 1179, 3419], 'J.J.': [1076, 1180, 3420], 'Sun': [1077, 1181, 3421], 'X.M.': [1078, 1182, 3422], 'Garcia': [1079, 1183, 3423], 'A.B.': [1080, 1184, 3424], 'Soutar': [1081, 1185, 3425], 'A.K.': [1082, 1186, 3426], '2004;': [1086, 1190, 3430, 3458], '279:': [1087, 1191, 3431], '16237-16245Abstract': [1088, 1192, 3432], '(67)': [1096, 1200, 3440], '16Stockinger': [1099, 1203, 1571], 'Sailler': [1101, 1205, 1573], 'Strasser': [1103, 1207, 1575], 'Recheis': [1105, 1209, 1577], 'Fasching': [1107, 1211, 1579], 'D.': [1108, 1212, 1580, 2102, 2106], 'Kahr': [1109, 1213, 1581], 'L.': [1110, 1131, 1214, 1235, 1582, 2110, 2183, 2414, 3012, 3289, 3359, 3597, 3823, 4055, 4459, 4500], 'Schneider': [1111, 1215, 1583], 'W.J.': [1112, 1216, 1584], 'Nimpf': [1113, 1217, 1564, 1585], 'EMBO': [1115, 1146, 1219, 1250, 1587, 1751, 2198, 3027, 3304, 3374, 3612, 3838, 4070, 4448], '21:': [1118, 1222, 1590, 4451], '4259-4267Crossref': [1119, 1223, 1591], '(103)': [1122, 1226, 1594], '17van': [1125, 1229], 'Kerkhof': [1126, 1230, 1443, 1517, 2178, 2422, 2734, 3007, 3284, 3354, 3592, 3818, 4050], 'Lee': [1128, 1232, 2085, 2180, 3009, 3286, 3356, 3594, 3820, 4052], 'McCormick': [1130, 1234, 2182, 2419, 3011, 3288, 3358, 3596, 3822, 4054], 'Tetrault': [1132, 1236, 2184, 3013, 3290, 3360, 3598, 3824, 4056], 'Lu': [1134, 1238, 2186, 3015, 3292, 3362, 3600, 3826, 4058], 'Schoenfish': [1136, 1240, 2188, 3017, 3294, 3364, 3602, 3828, 4060], 'Oorschot': [1138, 1242, 2190, 3019, 3296, 3366, 3604, 3830, 4062], 'Strous': [1140, 1244, 1445, 1519, 1747, 2192, 2424, 2736, 3021, 3298, 3368, 3606, 3832, 4064], 'G.J.': [1141, 1245, 1446, 1520, 1748, 2193, 2425, 2737, 3022, 3299, 3369, 3607, 3833, 4065], 'Klumperman': [1142, 1246, 2194, 3023, 3300, 3370, 3608, 3834, 4066], '24:': [1149, 1253, 2201, 3030, 3307, 3377, 3615, 3841, 4073], '2851-2861Crossref': [1150, 1254, 2202, 3031, 3308, 3378, 3616, 3842, 4074], '(119)': [1153, 1257, 2205, 3034, 3311, 3381, 3619, 3845, 4077], 'LDLR': [1164, 1168, 4413], 'members,': [1166], 'LRP1,': [1170], 'motifs': [1174, 4411], 'their': [1176, 1263, 3131, 4393, 4418], 'domains': [1178], 'Scholar)': [1259, 3313, 3621], 'In': [1266], 'this': [1267, 3126, 3171, 3176], 'study,': [1268], 'demonstrate': [1270], 'an': [1275, 1598, 1966, 2311, 2486, 3002, 3391, 3569, 3716], 'further': [1290, 2363, 3558], 'show': [1291], 'mediates': [1294, 4417], 'endocytosis.': [1296], 'study': [1298], 'provides': [1299], 'multiple': [1303, 3673], 'steps': [1304], 'are': [1309, 4160, 4204, 4307, 4358, 4383], 'distinct': [1312], 'proteins.': [1314, 1770], 'allow': [1327], 'new': [1330, 3892], 'cellular': [1334, 3512, 3574, 3631, 3652, 3677, 3704, 3849], 'underlying': [1336], 'Antibodies': [1343, 1502], 'Reagents—The': [1345], 'polyclonal': [1346, 1383], 'anti-SNX17': [1347, 1366, 2216, 2621, 2675, 4111, 4289], 'antibody': [1348, 1384, 1397, 1415, 1427, 2135, 4099, 4131, 4186], 'was': [1349, 1368, 1417, 1428, 1470, 1496, 1558, 1622, 2075, 2132, 2145, 2168, 2210, 2222, 2237, 2292, 2323, 2408, 2504, 2723, 2820, 2852, 2886, 2945, 2961, 3056, 3069, 3088, 3135, 3203, 3220, 3504, 3550, 3647, 3690, 3710, 3722, 3730, 3767, 3877, 3903, 3940, 3968, 4324], 'raised': [1350], 'against': [1351, 2235, 2452], '14-amino': [1353], 'acid': [1354], 'corresponding': [1356], 'carboxyl-terminal': [1359, 3325], 'region': [1360], 'protein.': [1363], 'Polyclonal': [1364], 'rabbit': [1365, 2617], 'IgG': [1367, 1469, 2540, 2600, 2605, 2614, 2619, 2811], 'purified': [1369, 1710], 'using': [1370, 1505, 1682, 1940, 2009, 2215, 2242, 2336, 2526, 2708, 3074, 3888, 3931, 3980, 4288, 4326], 'A': [1372, 1421], 'beads': [1373, 1763, 1777, 1845, 1857, 2508], 'Western': [1377, 1431, 1867, 1952, 2213, 2240, 2382, 3072, 3522, 3639, 3670, 4286, 4321], 'blotting': [1378, 2214, 2241, 3073, 3523, 3640, 4287], 'immunofluorescence': [1380, 1434], 'experiments.': [1381], 'recognizing': [1385, 1399], 'C-terminal': [1386, 3746], 'regions': [1387, 4299], 'human': [1390], 'mouse': [1392, 2603, 4282], 'APPs': [1393], 'monoclonal': [1396, 1424], '(6E10)': [1398, 2673], 'amino': [1400], 'acids': [1401], '1-17': [1402], 'were': [1405, 1486, 1503, 1606, 1651, 1677, 1690, 1697, 1739, 1764, 1778, 1806, 1837, 1858, 1876, 1915, 1934, 1955, 1973, 1998, 2007, 2021, 2034, 2057, 2154, 2252, 2277, 2302, 2331, 2334, 2346, 2354, 2377, 2392, 2454, 2483, 2524, 2536, 2573, 2628, 2647, 2661, 2697, 2761, 2769, 2781, 2827, 2843, 2867, 2908, 3519, 3622, 3636, 3656, 3681, 3748, 3752, 3784, 4095, 4176, 4295, 4366], 'purchased': [1406, 1497], 'Invitrogen': [1408], 'Covance': [1410], '(Berkeley,': [1411], 'CA),': [1412], 'respectively.': [1413, 1951, 3526, 3643], 'Anti-Myc': [1414], '9E10': [1416], 'obtained': [1418, 1471], 'Sigma.': [1420], 'described': [1423, 1510, 1712, 2176, 2411, 2727, 3223], 'anti-hemagglutinin': [1425], '(HA)': [1426], 'blot': [1432, 4322], '(18Li': [1438, 1512, 2729], 'Marzolo': [1440, 1514, 2731, 4468], 'M.P.': [1441, 1515, 2732, 4469], 'van': [1442, 1516, 2733], '2000;': [1452, 1526, 2743], '275:': [1453, 1527, 2744], '17187-17194Abstract': [1454, 1528, 2745], '(191)': [1462, 1536, 2753], 'Fluorescein': [1465], 'isothiocyanate-conjugated': [1466, 2273], 'goat': [1467, 2274, 2598, 2612], 'anti-mouse': [1468, 2275, 2599], 'BD': [1473], 'Biosciences.': [1474], 'For': [1475, 1597, 1995, 2861], 'assays': [1478], '(ELISAs),': [1479], 'antibodies': [1480, 2622], '21F12,': [1481], '2G3,': [1482], 'biotinylated': [1484, 2149], '3D6': [1485, 2150], 'kind': [1488], 'gifts': [1489], 'Kelly': [1491], '(Lilly).': [1493], 'Carrier-free': [1494], 'Na125I': [1495], 'PerkinElmer': [1499], 'Life': [1500], 'Sciences.': [1501], 'iodinated': [1504], 'IODO-GEN': [1507], 'method': [1508], 'Plasmids': [1539], 'Fusion': [1541], 'Proteins—Mouse': [1542], 'cDNA': [1544], 'tagged': [1545], '5′': [1548], 'end': [1549], '9-Myc': [1552], 'epitope': [1553], 'cloned': [1555], 'into': [1556, 1608, 2224, 3508, 3624], 'pCIneo': [1557], 'kindly': [1559, 1652], 'provided': [1560, 1624, 1653], 'Dr.': [1562, 1626, 1655], 'Johannes': [1563], '(University': [1565, 1629], 'Vienna,': [1567], 'Austria;': [1568], 'see': [1569], 'Ref.': [1570], 'siRNA-resistant': [1599, 3717, 3727, 3756], 'Myc-SNX17': [1600, 1795], 'construct,': [1601], 'eight': [1602], 'silent': [1603], 'nucleotide': [1604], 'mutations': [1605, 3146], 'introduced': [1607, 1678], 'sequence': [1610], 'targeted': [1611], 'siRNAs.': [1615], 'GST-fused': [1617, 3052], 'tail': [1620, 1676, 3115, 3163, 3202], 'construct': [1621, 2219, 3729, 3758], 'generously': [1623], 'Thomas': [1627], 'Südhof': [1628], 'Texas,': [1631], 'Southwestern': [1632], 'Medical': [1633], 'Center).': [1634], 'Constructs': [1635], 'full-length': [1637, 3213, 3539], '(PTB)': [1642], 'GST-full-length': [1645], 'GST-PTB': [1649], 'Linton': [1656], 'Traub': [1657, 4446], '(Department': [1658], 'Biology': [1661], 'Physiology,': [1663], 'University': [1664], 'Pittsburgh': [1666], 'School': [1667], 'Medicine,': [1669], 'Pittsburgh,': [1670], 'PA).': [1671], 'Mutations': [1672], 'site-directed': [1680], 'mutagenesis': [1681, 1685], 'QuikChange': [1684], 'kit': [1686], '(Stratagene).': [1687], 'All': [1688, 2300], 'constructs': [1689, 2025, 2052], 'verified': [1691], 'sequencing.': [1693], 'GST': [1694, 1734, 3049, 3138], 'fusion': [1695, 1737, 1769, 1840], 'produced': [1698, 3551], 'Escherichia': [1701], 'coli': [1702], 'BL21': [1703], 'strain': [1704], '(Novagen,': [1705], 'San': [1706], 'Diego,': [1707], 'CA)': [1708], '(19Bu': [1714, 1892], 'Maksymovitch': [1716, 1894], 'E.A.': [1717, 1895], 'Geuze': [1718, 1745, 1896, 2415], 'Schwartz': [1720, 1749, 1898, 2426], 'A.L.': [1721, 1750, 1899, 2427], '1994;': [1725, 1903], '269:': [1726, 1904], '29874-29882Abstract': [1727, 1905], 'Pulldown': [1735], 'Assay—GST': [1736], 'bacteria': [1742], '(20Bu': [1743], 'H.J.': [1746, 2416], '1995;': [1753], '14:': [1754], '2269-2280Crossref': [1755], '(271)': [1758], 'added': [1765, 2821], 'Following': [1771, 2366], 'incubation': [1772, 1989, 2256, 2367, 2590, 2689, 2889], 'overnight': [1773, 2778], '4': [1775, 1853, 2281], '°C,': [1776, 2686, 4105], 'washed': [1779, 2035], 'twice': [1780, 2036, 2783, 2893], 'PBS': [1782, 1976, 2576, 2650, 2664, 2677, 2786], 'resuspended': [1784], 'buffer.': [1788], 'U87': [1790, 1874, 1928, 3061, 3208, 3509, 3625, 4089, 4174, 4378], 'stable': [1791], 'line': [1793], 'expressing': [1794, 1801, 3064, 3211], 'plasmids': [1796], 'CHO': [1798, 1912, 1931], 'LRP-null': [1799, 1913, 1932], 'cells': [1800, 1875, 1914, 1929, 1933, 2033, 2225, 2251, 2327, 2376, 2442, 2572, 2696, 2760, 2768, 2866, 3062, 3209, 3544, 3554, 3664, 3714, 3751, 3790, 3796, 3856, 3882, 3887, 3909, 3919, 3946, 3955, 3973, 4090, 4175], 'wild-type': [1802], 'lysed': [1807, 2378], 'lysis': [1809, 1847, 2913], 'buffer': [1810, 1848, 1863, 2514, 2554, 2565, 2797, 2819, 2851, 2914], '(20': [1811], 'mm': [1812, 1817, 1820, 1826, 2916], 'Tris-HCl,': [1813], 'pH': [1814, 2859, 2918], '8.0,': [1815], '100': [1816], 'NaCl,': [1818], 'EDTA,': [1821], '0.5%': [1822, 2568], 'Nonidet': [1823], 'P-40,': [1824], 'phenylmethylsulfonyl': [1827], 'fluoride,': [1828], '1×': [1830], 'Complete': [1831], 'protease': [1832], 'inhibitor': [1833], 'mixture).': [1834], 'lysates': [1836, 2482, 3059, 3206], 'incubated': [1838, 2355, 2455, 2484, 2537, 2670, 2789, 3057, 3204, 4096], 'bound': [1842], '2': [1850, 2475], 'h': [1851, 2061, 2543, 2593, 2758, 4102], '°C.': [1854], 'After': [1855, 2477, 2561, 2815, 2838], 'washing,': [1856], 'boiled': [1859], 'SDS': [1861], 'sample': [1862, 2330, 2391, 2513], 'subjected': [1865, 1987, 2380], 'blotting.': [1868, 2383], 'Culture': [1870], 'Transfection—Human': [1872], 'glioblastoma': [1873], 'maintained': [1877], "Dulbecco's": [1879], 'modified': [1880, 2799], "Eagle's": [1881, 2800], 'medium': [1882, 1920, 2039, 2131, 2457, 2467, 2801], 'containing': [1883, 1977, 2458, 2567, 2577, 2651, 2665, 2678, 2802, 2807, 4172], '10%': [1884, 1922, 2922], 'fetal': [1885, 1923, 2042], 'bovine': [1886, 1924, 2043, 2569, 2804], 'serum,': [1887], 'l-glutamine,': [1888], 'sodium': [1890], 'pyruvate': [1891], 'grown': [1916], "Ham's": [1918], 'F-12': [1919], 'serum': [1925, 2570, 2805], 'l-glutamine.': [1927], 'transfected': [1935, 2022, 2444, 2763, 4092], 'various': [1937], 'plasmid': [1938], 'DNAs': [1939], 'Lipofectamine': [1941], '2000': [1942], '(Invitrogen)': [1943], 'TransIT-CHO': [1945], '(Mirus': [1946], 'Bioscience,': [1947], 'Madison,': [1948], 'WI)': [1949], 'reagent,': [1950], 'Blot': [1953], 'Analysis—Proteins': [1954], 'separated': [1956], 'on': [1957, 2304, 2845, 2869, 2882, 2939, 3486, 3701], 'SDS-polyacrylamide': [1958], 'gels': [1959], 'under': [1960, 2515], 'reducing': [1961, 2516], 'conditions': [1962, 2517], 'transferred': [1964], 'Immobilon-P': [1967], 'membrane': [1968], '(Millipore,': [1969], 'Billerica,': [1970], 'MA).': [1971], 'Membranes': [1972], 'blocked': [1974], '0.05%': [1978], 'Tween': [1979], '20': [1980, 2556, 2658], '5%': [1982], 'nonfat': [1983], 'dried': [1984], 'milk': [1985], 'primary': [1991, 2298, 4327, 4362], 'secondary': [1993, 2693, 4117], 'antibodies.': [1994, 4118], 'quantification,': [1996], 'blots': [1997, 3671], 'developed': [1999], 'ECL': [2001], 'Plus': [2002], 'reagent': [2003], '(Amersham': [2004, 2014], 'Biosciences)': [2005, 2308], 'analyzed': [2008, 2076, 2211, 2519, 3472, 3573, 4272], 'Typhoon': [2011], '9410': [2012], 'PhosphorImager': [2013], 'Biosciences).': [2015], 'ELISA—Cells': [2017], '6-well': [2019, 2766], 'plates': [2020, 2826, 2842], 'be': [2027, 3858], 'examined.': [2028], 'next': [2030], 'day,': [2031], 'low-serum': [2038, 2054, 2130], '(containing': [2040], '1%': [2041], 'serum)': [2044], 'retransfected': [2046], 'set': [2050], 'medium.': [2055], 'Media': [2056], 'collected': [2058], 'after': [2059, 2342, 2759, 2777, 2872, 2942, 4184, 4224], '48': [2060], 'conditioning': [2063], 'then': [2065, 2582, 2788, 2909, 4108], 'centrifuged': [2066], 'remove': [2068], 'debris.': [2070], 'media': [2074], 'ELISA': [2078], 'adapted': [2079], 'previous': [2081, 3266, 3803], '(21Johnson-Wood': [2083], 'K.': [2084, 2090, 2096], 'Motter': [2087], 'Hu': [2089], 'Gordon': [2091, 2097], 'Barbour': [2093], 'Khan': [2095], 'Tan': [2099], 'Games': [2101], 'Lieberburg': [2103], 'I.': [2104], 'Schenk': [2105], 'Seubert': [2107], 'McConlogue': [2109], '1997;': [2118], '94:': [2119], '1550-1555Crossref': [2120], '(584)': [2123], 'Specially,': [2126], 'captured': [2133], '2G3': [2136], '21F12': [2138], 'Aβ40': [2140], 'Aβ42,': [2142], 'respectively,': [2143, 3500], 'subsequently': [2146], 'detected': [2147, 4296], 'antibody.': [2151, 2217, 2244, 2299, 2694, 3076, 4290], 'normalized': [2155], 'amount': [2158], 'total': [2160, 2387, 2900], 'lysates.': [2164], 'Knockdown—SNX17': [2166], 'suppressed': [2169, 3648], 'transiently': [2171, 2443, 2762, 4091], 'transfecting': [2172], 'siRNA': [2173, 2227, 2233, 2450, 3589, 3650, 3662, 3734, 3794, 3885, 3917], 'oligonucleotides': [2174], '(17van': [2177, 3006, 3283, 3353, 3591, 3817, 4049], 'Rescue': [2218], 'cotransfected': [2223, 3505, 3623, 3731, 3753], 'oligonucleotides,': [2228], 'resistance': [2231], 'oligonucleotide': [2234, 2451, 3590, 3735], 'examined': [2238, 3070, 3136, 3221, 3520, 3637, 3878, 4278], 'anti-Myc': [2243, 3075], 'Flow': [2245], 'Cytometry—For': [2246], 'analysis,': [2250], 'first': [2253], 'detached': [2254], 'non-enzymatic': [2258], 'dissociation': [2260], 'solution': [2261, 2857, 2897], '(Sigma).': [2262], 'Successive': [2263], 'incubations': [2264], 'anti-APP': [2266, 2672], '(50': [2267], 'μg/ml)': [2268], 'fluorescein': [2272, 2321], 'Ig': [2276], 'carried': [2278, 2724], 'out': [2279, 2725], '°C': [2282, 2546, 2832], 'h.': [2285, 2476, 2814], 'As': [2286, 3077, 3225, 4188, 4333], 'control,': [2288], 'background': [2289], 'fluorescence': [2290], 'intensity': [2291], 'assessed': [2293], 'absence': [2296], 'measurements': [2301], 'performed': [2303, 2409, 4325], 'FACSCalibur': [2306], '(BD': [2307], 'equipped': [2309], 'argon': [2312], 'ion': [2313], 'laser.': [2314], 'Laser': [2315], 'excitation': [2316], '488': [2318], 'nm': [2319, 2809], 'isothiocyanate': [2322], 'used.': [2324], 'Ten': [2325], 'thousand': [2326], 'each': [2329, 2390, 2395, 2478, 2943, 2958, 3123], 'analyzed.': [2332], 'Histograms': [2333], 'CellQuest': [2338], 'software;': [2339], 'mean': [2340], 'values': [2341], 'subtraction': [2343], 'controls': [2345], 'compared': [2347, 3537, 3659, 3791, 3914, 3951], 'among': [2348], 'samples.': [2349], 'Determination': [2350], 'Protein': [2352], 'Half-life—Cells': [2353], 'cycloheximide': [2357, 3889], '(100': [2358], 'μg/ml;': [2359], 'Sigma)': [2360], 'inhibit': [2362, 3891], 'synthesis.': [2365, 3894], '0,': [2369, 2471], '15,': [2370], '30,': [2371], '45,': [2372], '60': [2374, 2633], 'min,': [2375, 2462, 2840], 'Equal': [2384], 'amounts': [2385, 4292], 'loaded': [2393], 'lane.': [2396], 'Metabolic': [2397], 'Pulse-Chase': [2398], 'Labeling': [2399], 'Immunoprecipitation—Metabolic': [2401], 'pulse-chase': [2402, 3929], 'labeling': [2403], 'HA-APP': [2405, 2446, 3507, 3584, 4094], '[35S]Met/Cys': [2407, 2459, 2469, 3932], '(22Melman': [2413], 'Van': [2421], '13:': [2434], '3325-3335Crossref': [2435], '(39)': [2438, 4263], 'Briefly,': [2441, 2756], 'control': [2448, 3586, 3661, 3793, 3884, 3916, 3953], '30': [2461, 2682], 'followed': [2463, 2491, 2588, 2687, 4113], 'chasing': [2465], 'without': [2468, 4144], '0.5,': [2472], '1,': [2473], 'time': [2479, 2864, 2959], 'point,': [2480, 2865], 'excess': [2487], 'anti-HA': [2489, 2539, 2604, 2618, 4098, 4130, 4185], 'IgG,': [2490], 'recovery': [2493], 'immune': [2496], 'complexes': [2497], 'A-agarose': [2500], 'beads.': [2501], 'Immunoprecipitated': [2502], 'released': [2505], 'boiling': [2510], 'Laemmli': [2512], 'SDS-PAGE.': [2521], 'Radioactive': [2522], 'visualized': [2525], 'STORM': [2528], '820': [2529], 'PhosphorImager.': [2530], 'Antibody': [2531], 'Uptake': [2532], 'Staining—Cells': [2535], '37': [2545, 2685, 2831, 4104], 'fixed': [2548, 2648], '4%': [2550, 2652, 2655], 'paraformaldehyde': [2551, 2653], 'phosphate': [2553], 'min': [2557, 2683, 2903], 'room': [2559], 'temperature.': [2560], 'blocking': [2562, 2564], '(PBS': [2566], 'albumin),': [2571], 'permeabilized': [2574, 2662], '0.2%': [2578, 2666, 2679, 2920], 'Triton': [2579, 2667], 'X-100': [2580, 2668], 'stained': [2583, 4109, 4177, 4367], 'EEA1,': [2587, 4183], 'Alexa': [2595, 2609, 2691], 'Fluor': [2596, 2610], '586-conjugated': [2597], 'detect': [2602, 2616], 'anti-EEA1': [2607], '488-conjugated': [2611], 'anti-rabbit': [2613], '(Molecular': [2623], 'Probes,': [2624], 'Carlsbad,': [2625], 'CA).': [2626], 'Cells': [2627, 2780], 'mounted': [2629], 'Cytoseal': [2632], '(Richard-Allan': [2634], 'Scientific,': [2635], 'Kalamazoo,': [2636], 'MI).': [2637], 'Cultured': [2638], 'rat': [2639], 'hippocampal': [2640, 4331, 4364, 4387], 'neurons,': [2641, 4361, 4388], 'isolated': [2642], 'day': [2644], '18': [2645], 'embryos,': [2646], 'sucrose': [2656], 'min.': [2659], 'Neurons': [2660], 'gelatin': [2680], 'Fluor-conjugated': [2692], 'Stained': [2695], 'viewed': [2698], 'confocal': [2701], 'laser': [2702], 'scanning': [2703], 'microscope': [2704], '(Fluoview': [2705], '500,': [2706], 'Olympus)': [2707], '×60': [2710], 'objective': [2711], 'oil': [2712], 'immersion': [2713], 'lens.': [2714], 'Kinetic': [2715], 'Analysis': [2716], 'Endocytosis—Kinetic': [2718], 'analysis': [2719, 4323], 'receptor-mediated': [2721], '8': [2757], 'plate,': [2767], 'replated': [2770], '12-well': [2773], 'plate': [2774], 'culture.': [2779], 'rinsed': [2782], 'cold': [2785], '0.5': [2791], 'ml': [2792], 'ice-cold': [2794, 2855, 2895], 'ligand': [2795, 2849, 2873, 2936, 2956], 'binding': [2796, 2818, 2850, 2874, 2987, 3068, 3102, 3132, 3166, 3197, 3219, 3257, 3318], "(Dulbecco's": [2798], '0.6%': [2803], 'albumin)': [2806], '125I-anti-HA': [2810], 'binding,': [2816, 3120], 'prewarmed': [2817], 'cells,': [2824, 3510, 3626, 4379], 'placed': [2828, 2844, 2868], 'water': [2833], 'bath': [2834], 'initiate': [2836], 'internalization.': [2837, 2951], '15': [2839], 'ice,': [2846], 'replaced': [2853], 'stop/strip': [2856, 2896], '(PBS,': [2858], '2.0).': [2860], '0-min': [2863], 'ice': [2870], 'immediately': [2871], 'processed': [2876], 'follows.': [2878], 'Ligand': [2879], 'remained': [2881], 'stripped': [2887], 'monolayers': [2892, 2907], '10': [2902], 'counted.': [2905], 'solubilized': [2910], 'low-SDS': [2912], '(6.25': [2915], 'Tris,': [2917], '6.8,': [2919], 'SDS,': [2921], 'glycerol,': [2923], 'bromphenol': [2925], 'blue)': [2926], 'release': [2928], 'internalized': [2929, 2935, 2955, 4035, 4139], 'radioactivity.': [2930], 'sum': [2932], 'plus': [2937], 'those': [2938], 'assay': [2944, 3140], 'maximum': [2949], 'potential': [2950], 'fraction': [2953], 'point': [2960], 'calculated': [2962], 'plotted.': [2964], 'Binds': [2966, 4400], 'Cytoplasmic': [2970], 'Domain': [2971], 'Motif—The': [2975], 'contains': [2979, 4480], 'responsible': [2985, 3117], '(Fig.': [2994, 3094, 3141, 3545, 3555, 3665, 3736, 3924, 3960, 3974, 4211], '1A).': [2995, 3142], 'Because': [2996, 4119, 4200], 'LRP1': [3000, 3282, 3343, 3351, 4304, 4342], 'analogous': [3003], 'tested': [3038], 'ability': [3040], 'domain.': [3048], 'stably': [3063, 3210], 'Myc-tagged': [3065, 3212], 'SNX17,': [3066, 3168, 3185, 3194, 3217, 4338], 'Fig.': [3080, 3228, 3502, 4153, 4191, 4336, 4397], '1A,': [3081], 'GST-APP': [3083, 3201], 'tail,': [3084, 3246], 'but': [3085], 'able': [3089], '1A),': [3095], 'suggesting': [3096, 3762], 'To': [3106, 3178, 3557, 3695, 4080, 4167, 4310, 4352], 'analyze': [3107], 'whether': [3108, 3180, 4082, 4312, 4354], 'YXN-PXY': [3110], 'mutated': [3122], 'residue': [3124, 3150], 'alanine,': [3129], 'pulldown': [3139], 'found': [3144, 3740, 3777, 3964], 'critical': [3149, 3174, 3991], 'Tyr757,': [3151], 'Asn759,': [3152], 'Pro760,': [3153], 'Tyr762': [3155], 'abrogated': [3164], 'indicating': [3169, 3247], 'interaction.': [3177], 'determine': [3179, 4311], 'PX': [3182, 3215, 3233, 3250, 3271, 3410, 3484], 'required': [3188, 3254, 3466], 'endosomal': [3191, 3415, 4181, 4209], 'participates': [3195], 'domain-deleted': [3216], 'above.': [3224], '1B,': [3229], 'deletion': [3230, 3407], 'did': [3235], 'interaction': [3239, 3278], 'This': [3260], 'result': [3261], 'consistent': [3263, 3800, 3976], 'finding': [3267], 'necessary': [3275], 'suggests': [3315], 'resides': [3322], 'SNX17.': [3328, 3774], 'Regulates': [3330, 4404], 'Processing': [3332], 'Production—We': [3335], 'similar': [3346], 'promotes': [3350], 'recycling': [3352], 'Thus,': [3384, 3872], 'reasoned': [3386], 'play': [3390], 'important': [3392], 'role': [3393], 'It': [3402, 4234], 'abrogates': [3412], '23Williams': [3443], 'Schluter': [3445, 4250], 'Roberts': [3447], 'M.S.': [3448], 'Knauth': [3449], 'Bohnensack': [3451, 4252], 'Cutler': [3453], 'D.F.': [3454], '15:': [3459], '3095-3105Crossref': [3460], 'function.': [3469], 'Therefore,': [3470], 'effects': [3474], 'overexpressing': [3476], 'lacking': [3482], 'stability': [3488, 3998], 'processing.': [3490, 4013], 'Full-length': [3491], 'PX-deleted': [3493], '(indicated': [3495], 'ΔPX-SNX17,': [3499], '2A)': [3503], 'Coexpression': [3527], 'ΔPX-SNX17': [3529], 'dramatically': [3530], 'SNX17-': [3540], 'pcDNA3': [3542], 'vector-transfected': [3543], '2B),': [3546], 'more': [3548, 4008], 'ΔPX-SNX17-cotransfected': [3553], '2C).': [3556], 'examine': [3559, 4081, 4353], 'alternative': [3570], 'approach,': [3571], 'secreted': [3577], 'cells.': [3583], 'When': [3644, 4001], 'oligonucleotide,': [3651], 'oligonucleotide-transfected': [3663], '3A).': [3666], 'Quantification': [3667], 'experiments': [3674, 3930], '∼75%': [3684], 'when': [3685, 3725, 3750, 3866], 'knocked': [3691, 3870], 'down': [3692], '∼90%.': [3694], 'confirm': [3696], 'effect': [3698], 'rescued': [3711], 'cotransfecting': [3713], 'construct.': [3719], 'significantly': [3723, 3785, 3904], 'restored': [3724], '3B).': [3737], 'fragment': [3747], '(data': [3759, 3797], 'shown),': [3761, 3799], 'ameliorated': [3768], 'restoring': [3770], 'oligonucleotide-treated': [3795, 3886, 3918], 'report': [3804], 'LRP': [3816], 'Reduced': [3848], 'due': [3859], 'faster': [3862], 'turnover': [3863], 'down.': [3871], 'half-life': [3874, 3900, 3937], 'Consistent': [3895, 4373], 'our': [3897], 'hypothesis,': [3898], '(t½': [3910, 3920, 3947, 3956], '∼': [3911, 3921, 3948, 3957], '42': [3912], 'min)': [3913, 3923, 3950, 3959], '98': [3922], '3C).': [3925], 'Results': [3926], 'metabolic': [3928], '21': [3949], 'siRNA-treated': [3954], '43': [3958], '3D).': [3961], 'increased': [3969], '3E),': [3975], 'ΔPX-SNX17.': [3982], 'Together,': [3983], 'these': [3984, 4214, 4232], 'data': [3985], 'suggest': [3986], 'reduced,': [4005], 'likely': [4009, 4227], 'undergo': [4011], 'amyloidogenic': [4012], 'Colocalizes': [4015], 'Is': [4019], 'Highly': [4020], 'Expressed': [4021], 'Central': [4023], 'Nervous': [4024], 'System': [4025], 'Neurons—APP': [4026], 'type': [4029], 'I': [4030], 'traffics': [4037], 'pathway.': [4041, 4152], 'endosome': [4048], 'present': [4085], 'SNX17-containing': [4087], 'endosomes,': [4088], 'fixed,': [4106], 'antibody,': [4112], 'detection': [4115], 'HA': [4121], 'tag': [4122], 'N': [4126], 'terminus': [4127], 'uptake': [4132], 'represents': [4133], 'contribution': [4145], 'population': [4148], 'biosynthetic': [4151], '4C': [4154], 'shows': [4155], 'partially': [4161, 4196], 'colocalized': [4162, 4197, 4359, 4385], 'punctate': [4164, 4390], 'perinuclear': [4165], 'structures.': [4166], 'identify': [4168], 'compartments': [4171, 4210], 'marker,': [4182], 'uptake.': [4187], '4,': [4192, 4212], 'D-F,': [4193], 'EEA1.': [4199], 'EEA1': [4203], 'G-I),': [4213], 'indicate': [4216], 'enters': [4221], 'internalization': [4225], 'interacts': [4228, 4485], 'mRNA': [4240], 'brain': [4245, 4283, 4302], 'liver': [4247], '(24Florian': [4248], 'Biochem.': [4254], 'Res.': [4256], 'Commun.': [4257], '1045-1050Crossref': [4260], 'Scholar);': [4265], 'however,': [4266], 'level.': [4276], 'tissues': [4284], 'Significant': [4291], 'different': [4298], 'where': [4303], 'expressed.': [4309], 'brain,': [4320], 'cultured': [4328, 4363], 'cortical': [4329], 'neurons.': [4332, 4351], '5B,': [4337], 'well': [4340], 'types': [4349], 'structures': [4391], 'processes': [4394], '(arrows': [4395], '5C).': [4398], 'Endocytosis—Dab2': [4406], 'ApoER2': [4415], 'clathrin-coated': [4421], 'pits': [4422], '25Mishra': [4436], 'S.K.': [4437], 'Keyel': [4438], 'P.A.': [4439], 'Hawryluk': [4440], 'M.J.': [4441], 'Agostinelli': [4442], 'N.R.': [4443], 'Watkins': [4444], 'S.C.': [4445], '4915-4926Crossref': [4452], '(252)': [4455], '26Cuitino': [4458], 'Matute': [4460], 'Retamal': [4462], 'C.': [4463], 'Inestrosa': [4466], 'N.C.': [4467], '6:': [4472], '820-838Crossref': [4473], '(58)': [4476], 'PTB': [4482], 'domain,': [4483], 'target': [4488], 'phosphoinositide': [4492], 'moieties': [4493], 'certain': [4495], 'lipids': [4496], '(27Yun': [4497], 'Keshvara': [4499], 'Park': [4501, 4513], 'C.G.': [4502], 'Zhang': [4503], 'Y.M.': [4504], 'Dickerson': [4505], 'J.B.': [4506], 'Zheng': [4507], 'Rock': [4509], 'C.O.': [4510], 'Curran': [4511], 'H.W.': [4514], '2003;': [4518], '278:': [4519], '36572-36581Abstract': [4520], '(104)': [4528], 'G': [4529]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2153266207', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-25T05:03:58.936420', 'created_date': '2016-06-24'}