Publication Information

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'https://openalex.org/W2056997115', 'https://openalex.org/W2051063130', 'https://openalex.org/W2004018261', 'https://openalex.org/W1759444849', 'https://openalex.org/W1590358247', 'https://openalex.org/W1541282095'], 'abstract_inverted_index': {'Poly(ADP-ribosylation),': [0, 207], 'primarily': [1, 208, 3032], 'via': [2, 209, 578, 612, 3934, 4056], 'poly(ADP-ribose)': [3, 210, 414, 608, 1542, 1664], 'polymerase-1': [4, 211, 415, 429, 4186], '(PARP-1),': [5, 212], 'is': [6, 178, 213, 385, 964, 2399, 2927, 3000, 3540, 3723, 3808, 4106, 4130], 'a': [7, 166, 170, 214, 373, 377, 831, 914, 918, 924, 965, 1012, 1378, 1525, 1538, 1564, 1706, 1714, 1734, 1817, 1900, 1931, 2052, 2064, 2095, 2149, 2153, 2178, 2264, 2368, 2873, 3516, 3703, 3894, 4094, 4098, 4162], 'pluripotent': [8, 215], 'cellular': [9, 96, 120, 216, 303, 327, 650, 861, 884, 2391, 2501, 2597, 2623, 2995, 3014, 3586, 3718, 4147, 4182], 'process': [10, 168, 217, 375, 916, 4096], 'important': [11, 190, 218, 397, 3221, 3809], 'for': [12, 193, 219, 400, 569, 641, 944, 1047, 1166, 1206, 1483, 1512, 1546, 1765, 1787, 1904, 1913, 1919, 1976, 2071, 2183, 2230, 2245, 3705, 3897, 4113], 'maintenance': [13, 220], 'of': [14, 25, 68, 84, 100, 127, 132, 172, 221, 232, 275, 291, 307, 334, 339, 379, 582, 586, 593, 602, 607, 826, 840, 849, 920, 936, 946, 1021, 1062, 1380, 1528, 1541, 1677, 1698, 1844, 1851, 1965, 1993, 2156, 2159, 2197, 2210, 2250, 2256, 2282, 2304, 2329, 2342, 2355, 2386, 2390, 2559, 2566, 2586, 2589, 2602, 2617, 2630, 2645, 2723, 2853, 2864, 2876, 2935, 2942, 2951, 2980, 2988, 2994, 3013, 3018, 3205, 3535, 3574, 3713, 4100, 4122, 4128, 4142, 4181], 'genomic': [15, 222, 598, 2493, 3825], 'integrity': [16, 223], 'and': [17, 28, 37, 55, 70, 81, 95, 103, 119, 135, 141, 197, 204, 224, 235, 244, 262, 277, 288, 302, 310, 326, 342, 348, 404, 411, 610, 711, 843, 857, 863, 883, 905, 939, 955, 974, 977, 1034, 1053, 1070, 1147, 1373, 1408, 1473, 1501, 1537, 1618, 1655, 1690, 1795, 1825, 1831, 1947, 1979, 1995, 2080, 2085, 2105, 2162, 2172, 2223, 2236, 2239, 2243, 2275, 2286, 2299, 2333, 2363, 2511, 2514, 2596, 2604, 2609, 2622, 2633, 2650, 2727, 2867, 2944, 3021, 3214, 3231, 3401, 3411, 3421, 3499, 3676, 3826, 3905, 3928, 3955, 4023, 4088, 4126, 4154, 4175], 'RNA': [18, 225], 'transcription': [19, 226, 3899, 3932], 'in': [20, 227, 437, 444, 449, 451, 576, 595, 702, 707, 717, 781, 834, 1029, 1124, 1132, 1150, 1164, 1182, 1189, 1203, 1448, 1452, 1486, 1489, 1506, 1524, 1555, 1711, 1713, 1757, 1804, 1884, 1899, 1909, 1954, 2048, 2148, 2164, 2177, 2263, 2272, 2296, 2301, 2339, 2642, 2930, 2939, 2992, 3008, 3034, 3524, 3582, 3647, 3664, 3670, 3708, 3960, 3967, 3975, 4116, 4178, 4194, 4201], 'cells.': [21, 228, 3968], 'However,': [22, 229, 638, 2544, 4157], 'during': [23, 122, 230, 329, 604, 2388, 2564, 3715], 'conditions': [24, 231, 839, 935, 2389, 2565, 2934], 'oxidative': [26, 110, 123, 148, 176, 202, 233, 317, 330, 355, 383, 409, 784, 841, 870, 897, 962, 2397, 2549, 2613, 2680, 4104], 'stress': [27, 177, 203, 234, 384, 410, 842, 871, 963, 2550, 2681, 4105], 'energy': [29, 181, 205, 236, 388, 412, 613, 651, 894, 906, 2394, 2578, 2634, 2648, 2657, 3022, 3587, 3719, 4109, 4148, 4183], 'depletion,': [30, 237, 2503], 'poly(ADP-ribosylation)': [31, 46, 71, 85, 128, 157, 187, 238, 253, 278, 292, 335, 364, 394, 828, 851, 909, 2374, 2592, 2632, 3004, 3707, 3813, 3891, 3951, 3971, 4055, 4083, 4115, 4166], 'paradoxically': [32, 239], 'contributes': [33, 240, 2375, 2659, 3005, 4171], 'to': [34, 159, 169, 241, 366, 376, 597, 647, 658, 704, 774, 783, 917, 952, 1080, 1155, 1187, 1194, 1455, 1463, 1515, 1930, 1968, 1974, 2152, 2201, 2360, 2376, 2572, 2639, 2660, 2669, 2858, 3010, 3030, 3408, 3538, 3577, 3650, 3657, 3672, 3681, 3810, 3822, 4085, 4097, 4151, 4172], 'mitochondrial': [35, 75, 88, 242, 282, 295, 416, 827, 850, 853, 937, 1022, 1748, 2160, 2213, 2237, 2251, 2507, 2552, 2568, 2582, 2591, 2600, 2631, 2707, 2924, 2945, 3003, 3690, 3706, 3827, 3956, 4114, 4124, 4152], 'failure': [36, 243, 614, 907, 2395, 2579], 'cell': [38, 106, 150, 173, 245, 313, 357, 380, 708, 836, 866, 932, 1120, 1517, 2377, 2515, 2610, 3025, 3162, 3199, 3232, 3404, 3430, 3482, 3493, 3507, 3536, 3575, 3666, 3688, 3710, 4101, 4117, 4155, 4176], 'death.': [39, 151, 246, 358, 4156], 'Although': [40, 247], 'it': [41, 248, 2486, 2999, 3807], 'has': [42, 249, 2487, 2665, 3027, 3167, 3201], 'been': [43, 250, 2488, 2667, 3028, 3168], 'presumed': [44, 251], 'that': [45, 156, 252, 363, 824, 847, 887, 902, 1709, 2490, 2548, 2628, 2656, 3002, 3234, 3416, 3473, 3528, 3567, 3584, 3812, 4082, 4140], 'within': [47, 61, 74, 86, 254, 268, 281, 293, 644, 655, 911, 2730, 2870, 3952, 4168], 'the': [48, 66, 87, 160, 255, 273, 294, 367, 433, 587, 605, 639, 645, 1217, 1318, 1381, 1556, 1674, 1791, 1858, 1955, 1963, 1980, 2173, 2211, 2643, 2654, 2849, 2986, 3011, 3417, 3469, 3474, 3533, 3565, 3572, 3658, 3665, 4169, 4179, 4190], 'nucleus': [49, 256, 646], 'mediates': [50, 257], 'this': [51, 64, 258, 271, 570, 2981, 3961], 'pathologic': [52, 259], 'process,': [53, 260], 'PARP-1': [54, 69, 142, 261, 276, 349, 594, 642, 710, 929, 2990, 4144], 'other': [56, 198, 263, 405, 712, 978, 3693], 'poly(ADP-ribosyltransferases)': [57, 264], 'are': [58, 265, 714, 1731, 2651, 2872, 3406, 3700, 3721], 'also': [59, 116, 266, 323, 715, 880, 890, 2619, 2666, 3223, 3644, 3663, 3892, 3929, 3973], 'localized': [60, 267], 'mitochondria.': [62, 269], 'To': [63, 270], 'end,': [65, 272], 'presence': [67, 274], 'were': [72, 145, 279, 352, 1027, 1051, 1055, 1076, 1122, 1143, 1153, 1192, 1210, 1375, 1446, 1461, 1481, 1494, 1521, 1561, 1613, 1755, 1772, 1802, 1833, 1847, 1855, 1882, 1917, 1998, 2046, 2061, 2076, 2116, 2146, 2175, 2193, 2215, 2241, 2259, 2270, 2290, 2324, 2365], 'verified': [73, 280, 2140], 'fractions': [76, 283, 1620], 'from': [77, 138, 147, 165, 284, 345, 354, 372, 913, 1078, 1406, 2676, 3428, 3480, 4093], 'primary': [78, 285, 1661, 3687], 'cortical': [79, 286, 1073], 'neurons': [80, 137, 287, 344, 3427, 3677], 'fibroblasts.': [82, 289], 'Inhibition': [83, 290], 'compartment': [89, 296], 'preserved': [90, 117, 297, 324, 881], 'transmembrane': [91, 298, 417, 854], 'potential': [92, 299, 418, 855, 2874], '(ΔΨm),': [93, 300], 'NAD+content,': [94, 301], 'respiration,': [97, 304, 862, 885, 2598], 'prevented': [98, 129, 305, 336], 'release': [99, 306, 2253, 2510, 2601, 4127, 4174], 'apoptosis-inducing': [101, 133, 308, 340, 422, 1678], 'factor,': [102, 309, 967], 'reduced': [104, 311, 3491, 3510, 3645], 'neuronal': [105, 312, 446, 835, 865, 921], 'death': [107, 174, 314, 381, 447, 611, 867, 933, 2516, 2611, 3026, 3163, 3200, 3233, 3405, 3431, 3483, 3494, 3508, 3537, 3576, 4102, 4118, 4177], 'triggered': [108, 315, 868], 'by': [109, 180, 316, 387, 869, 893, 927, 1066, 1553, 1857, 2118, 2141, 2207, 2505, 2555, 2580, 2679, 3165, 3216, 3433, 3485, 4108], 'stress.': [111, 124, 318, 331, 898, 2614], 'Treatment': [112, 319, 874], 'with': [113, 201, 320, 408, 875, 1039, 1057, 1136, 1198, 1215, 1467, 1496, 1743, 1774, 1783, 1816, 1879, 2094, 2102, 2326, 2499, 2653, 3702, 4120], 'liposomal': [114, 321], 'NAD+': [115, 322, 603, 858, 877, 903, 1362, 1372, 1853, 1953, 1994, 1996, 2502, 2569, 2618, 2996, 3019], 'ΔΨm': [118, 325, 882, 2621], 'respiration': [121, 328], 'Furthermore,': [125, 332, 2615], 'inhibition': [126, 333, 825, 848, 2385, 2588, 2629, 2664, 2855, 3238, 3643], 'intranuclear': [130, 337], 'localization': [131, 338], 'factor': [134, 341, 423, 1679], 'protected': [136, 146, 343, 353], 'excitotoxic': [139, 346, 445, 4202], 'injury;': [140, 347], 'null': [143, 350], 'fibroblasts': [144, 351, 3648, 3675], 'stress-induced': [149, 356], 'Collectively': [152, 359, 4078], 'these': [153, 360, 2484, 3562, 3698, 4079, 4158], 'data': [154, 184, 361, 391, 2546, 2626, 3471, 3563, 3699, 4080, 4133, 4159], 'suggest': [155, 362, 901, 2547, 3564, 4081], 'compartmentalized': [158, 365, 654, 910, 4084, 4167], 'mitochondria': [161, 368, 718, 912, 1712, 2115, 2174, 2204, 2257, 2731, 2871, 4087, 4170], 'can': [162, 369, 889, 930, 4090], 'be': [163, 370, 659, 891, 3031, 3409, 3679, 4091], 'converted': [164, 371, 4092], 'homeostatic': [167, 374, 915, 3816, 3965, 4095], 'mechanism': [171, 378, 568, 919, 926, 4099], 'when': [175, 382, 4103], 'accompanied': [179, 386, 4107], 'depletion.': [182, 389], 'These': [183, 390, 948, 2625, 4132], 'implicate': [185, 392], 'intra-mitochondrial': [186, 393], 'as': [188, 395, 1085, 1575, 1621, 1733, 2008, 2121, 2205, 2277, 3209, 3226, 3818, 3958, 4053], 'an': [189, 396, 441, 1744, 1812, 1826, 1910, 4198], 'therapeutic': [191, 398], 'target': [192, 399], 'central': [194, 401, 957], 'nervous': [195, 402, 958], 'system': [196, 403, 959], 'diseases': [199, 406, 960, 980], 'associated': [200, 407, 4119], 'failure.': [206, 413, 4184], 'phosphate-buffered': [419], 'saline': [420], '5-iodo-6-amino-1,2-benzyopyrone': [421, 1220], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [424, 1944], 'bromide': [425, 1945, 2104], 'propridium': [426, 2336], 'iodide': [427, 1704, 2337], 'Poly(ADP-ribose)': [428, 4185], '(PARP-11;': [430, 4187], 'EC': [431, 4188], '2.4.2.30),': [432, 4189], 'most': [434, 4191], 'abundant': [435, 706, 4192], 'poly(ADP-ribosyltransferase)': [436, 4193], 'mammalian': [438, 4195], 'cells,': [439, 3685, 4196], 'plays': [440, 4197], 'essential': [442, 4199], 'role': [443, 833, 3704, 3896, 4112, 4200], 'both': [448, 953, 2940, 3824, 3953, 4086], 'vitroand': [450], 'vivo': [452], '(1Zhang': [453, 3036], 'J.': [454, 481, 526, 694, 728, 729, 762, 789, 1090, 1109, 1228, 1271, 1327, 1346, 1581, 1600, 1626, 1645, 1722, 2013, 2032, 2127, 2412, 2457, 2476, 2715, 2741, 2742, 2820, 2836, 2888, 3037, 3064, 3109, 3151, 3257, 3281, 3334, 3339, 3438, 3457, 3599, 3736, 3781, 3800, 3879, 4015, 4042], 'Dawson': [455, 457, 486, 490, 553, 555, 675, 677, 997, 2417, 2421, 2531, 2533, 2966, 3038, 3040, 3069, 3073, 3184, 3186, 3741, 3745], 'V.L.': [456, 491, 556, 678, 998, 2422, 2534, 2965, 3039, 3074, 3187, 3746], 'T.M.': [458, 487, 554, 676, 996, 2418, 2532, 2967, 3041, 3070, 3185, 3742], 'Snyder': [459, 488, 2419, 3042, 3071, 3743, 3911], 'S.H.': [460, 489, 515, 1092, 1329, 1583, 1628, 2015, 2420, 2446, 3043, 3072, 3098, 3440, 3744, 3770, 3912], 'Science.': [461, 557, 679, 2535, 3044, 3188, 3941, 4069], '1994;': [462, 3045, 3993], '263:': [463, 3046], '687-689Crossref': [464, 3047], 'PubMed': [465, 497, 534, 561, 633, 683, 735, 751, 767, 817, 990, 1114, 1253, 1276, 1309, 1351, 1441, 1605, 1650, 1727, 1874, 2037, 2132, 2428, 2465, 2539, 2699, 2720, 2748, 2764, 2781, 2801, 2825, 2845, 2899, 2918, 2961, 2973, 3048, 3080, 3117, 3140, 3192, 3263, 3304, 3345, 3394, 3462, 3556, 3605, 3634, 3752, 3789, 3842, 3865, 3886, 3923, 3945, 3996, 4020, 4073], 'Scopus': [466, 498, 535, 562, 634, 684, 752, 768, 818, 991, 1115, 1254, 1277, 1310, 1352, 1442, 1606, 1651, 1875, 2038, 2133, 2429, 2466, 2540, 2700, 2765, 2782, 2802, 2826, 2900, 2919, 2974, 3049, 3081, 3118, 3141, 3193, 3264, 3305, 3346, 3395, 3463, 3557, 3606, 3635, 3753, 3790, 3843, 3866, 3887, 3924, 3946, 3997, 4074], '(1076)': [467, 3050], 'Google': [468, 500, 537, 564, 636, 686, 699, 736, 754, 770, 803, 820, 993, 1117, 1233, 1256, 1279, 1312, 1354, 1404, 1444, 1608, 1653, 1728, 1877, 2040, 2135, 2431, 2468, 2481, 2542, 2702, 2721, 2749, 2767, 2784, 2804, 2828, 2846, 2902, 2921, 2962, 2976, 3051, 3083, 3120, 3143, 3156, 3195, 3266, 3307, 3348, 3397, 3465, 3559, 3608, 3637, 3755, 3792, 3805, 3845, 3868, 3889, 3926, 3948, 3999, 4021, 4047, 4076], 'Scholar,': [469, 501, 538, 687, 737, 755, 804, 994, 1257, 1280, 2432, 2469, 2750, 2768, 2785, 2805, 2829, 2903, 2963, 3052, 3084, 3121, 3144, 3267, 3308, 3349, 3609, 3756, 3793, 3869, 4000], '2Eliasson': [470, 3053], 'M.J.': [471, 503, 2402, 2434, 3054, 3086, 3726, 3758], 'Sampei': [472, 2403, 3055, 3727], 'K.': [473, 2404, 2689, 3056, 3316, 3546, 3627, 3728, 3857], 'Mandir': [474, 2405, 3057, 3729], 'A.S.': [475, 2406, 3058, 3730], 'Hurn': [476, 2407, 3059, 3731], 'P.D.': [477, 1102, 1339, 1593, 1638, 2025, 2408, 3060, 3450, 3732], 'Traystman': [478, 2409, 3061, 3733], 'R.J.': [479, 2410, 3062, 3734], 'Bao': [480, 2411, 3063, 3735], 'Pieper': [482, 2413, 3065, 3737], 'A.': [483, 629, 757, 787, 1243, 1296, 1305, 1428, 1437, 2414, 2797, 3066, 3136, 3250, 3375, 3550, 3617, 3621, 3738, 3919, 3938, 3940, 3992, 4004, 4010, 4065], 'Wang': [484, 541, 663, 2415, 2519, 2808, 3067, 3172, 3624, 3739], 'Z.Q.': [485, 2416, 3068, 3625, 3740, 3847], 'Nat.': [492, 2423, 3075, 3747], 'Med.': [493, 2424, 3076, 3259, 3341, 3601, 3748], '1997;': [494, 2425, 2798, 3077, 3602, 3749, 3862], '3:': [495, 1002, 2426, 3078, 3750], '1089-1095Crossref': [496, 2427, 3079, 3751], '(939)': [499, 2430, 3082, 3754], '3Whalen': [502, 2433, 3085, 3757], 'Clark': [504, 1107, 1344, 1598, 1643, 2030, 2435, 3087, 3455, 3759, 4040], 'R.S.': [505, 1108, 1345, 1599, 1644, 2031, 2436, 3088, 3456, 3760, 4041], 'Dixon': [506, 2437, 3089, 3761, 4032], 'C.E.': [507, 2438, 3090, 3762, 4033], 'Robichaud': [508, 2439, 3091, 3763], 'P.': [509, 724, 761, 795, 1290, 1422, 2440, 2691, 2737, 2881, 3092, 3248, 3285, 3322, 3598, 3764, 4006, 4008], 'Marion': [510, 2441, 3093, 3765], 'D.W.': [511, 2442, 3094, 3766], 'Vagni': [512, 2443, 3095, 3767], 'V.': [513, 2444, 3096, 3548, 3768], 'Graham': [514, 1091, 1328, 1582, 1627, 2014, 2445, 3097, 3439, 3769], 'Virag': [516, 1283, 1415, 2447, 3099, 3771], 'L.': [517, 689, 741, 982, 1094, 1223, 1284, 1331, 1387, 1416, 1585, 1630, 2017, 2448, 2471, 2754, 3100, 3146, 3314, 3369, 3442, 3772, 3795, 3849], 'Hasko': [518, 2449, 3101, 3773], 'G.': [519, 1239, 2450, 3102, 3256, 3299, 3330, 3338, 3387, 3774, 3876], 'Stachlewitz': [520, 2451, 3103, 3775], 'R.': [521, 743, 1098, 1335, 1589, 1634, 2021, 2452, 2683, 2756, 3104, 3293, 3377, 3446, 3776, 4012], 'Szabo': [522, 692, 983, 1103, 1226, 1268, 1340, 1594, 1639, 2026, 2453, 2474, 3105, 3149, 3451, 3777, 3798, 4038], 'C.': [523, 546, 616, 668, 693, 984, 1104, 1227, 1269, 1282, 1341, 1414, 1595, 1640, 2027, 2454, 2475, 2524, 2809, 2887, 2954, 3106, 3123, 3150, 3177, 3452, 3544, 3619, 3778, 3799, 3851, 3871, 4039], 'Kochanek': [524, 1095, 1332, 1586, 1631, 2018, 2455, 3107, 3443, 3779, 4030], 'P.M.': [525, 1096, 1333, 1587, 1632, 2019, 2456, 3108, 3444, 3780, 4031], 'Cereb.': [527, 2458, 3110, 3782], 'Blood': [528, 2459, 3111, 3783], 'Flow': [529, 2460, 3112, 3784], 'Metab.': [530, 2461, 3113, 3785], '1999;': [531, 2462, 2717, 2891, 2915, 3114, 3301, 3786, 4017], '19:': [532, 2463, 2718, 3115, 3787, 4018], '835-842Crossref': [533, 2464, 3116, 3788], '(143)': [536, 2467, 3119, 3791], '4Yu': [539], 'S.W.': [540, 662, 2518, 3171], 'H.': [542, 664, 2520, 2714, 3173, 3379, 3983], 'Poitras': [543, 665, 2521, 3174], 'M.F.': [544, 666, 2522, 3175], 'Coombs': [545, 667, 2523, 3176], 'Bowers': [547, 669, 2525, 3178], 'W.J.': [548, 670, 2526, 2831, 3179], 'Federoff': [549, 671, 2527, 3180], 'H.J.': [550, 672, 2528, 3181], 'Poirier': [551, 673, 2529, 3182], 'G.G.': [552, 674, 2530, 3183], '2002;': [558, 680, 987, 1111, 1348, 1602, 1647, 2034, 2536, 2822, 3189, 3459, 3631, 3920], '297:': [559, 681, 2537, 3190], '259-263Crossref': [560, 682, 2538, 3191], '(1557)': [563, 685, 2541, 3194], 'Scholar).': [565, 637, 700, 1118, 1729, 2041, 2136, 2482, 2543, 2703, 2922, 2977, 3157, 3196, 3398, 3466, 3949, 4048, 4077], 'The': [566, 1519, 1779, 1970, 2098, 2978, 3526], 'presumptive': [567], 'neurotoxic': [571], 'effect': [572], 'involves,': [573], 'sequentially,': [574], 'increases': [575], '[Ca2+]i': [577, 2931], 'glutamate': [579, 3505], 'receptors,': [580], 'activation': [581, 592, 643, 2941, 2991, 3712], 'nitric-oxide': [583, 2865, 2925, 2946], 'synthase,': [584], 'generation': [585], 'free': [588], 'radical': [589], 'peroxynitrite': [590, 1320], '(ONOO−),': [591], 'response': [596, 782, 3671], 'DNA': [599, 779, 1038, 2044, 2056, 2494, 2607, 2728, 3210, 3229, 3828], 'damage,': [600], 'consumption': [601], 'formation': [606, 4025], 'polymers,': [609], '(5Szabo': [615], 'Zingarelli': [617, 1293, 1425, 3124], 'B.': [618, 1294, 1426, 2693, 2790, 3125, 3592], "O'Connor": [619, 1291, 1423, 3126], 'M.': [620, 722, 1259, 2735, 3127, 3244, 3254, 3287, 3320, 3590, 3611, 3613, 3853, 3855], 'Salzman': [621, 690, 1224, 1262, 1295, 1427, 2472, 3128, 3147, 3796], 'A.L.': [622, 691, 1225, 1263, 2473, 3129, 3148, 3797], 'Proc.': [623, 1299, 1431, 2791, 3130, 3913, 3986], 'Natl.': [624, 1300, 1432, 2792, 3131, 3914, 3987], 'Acad.': [625, 1301, 1433, 2793, 3132, 3915, 3988], 'Sci.': [626, 731, 1302, 1434, 2744, 2794, 3133, 3916, 3989], 'U.': [627, 1303, 1435, 2795, 2883, 3134, 3917, 3990], 'S.': [628, 1286, 1304, 1418, 1436, 1868, 2796, 3135, 3596, 3918, 3991, 4061], '1996;': [630, 732, 2745, 2958, 2970, 3137, 3260], '93:': [631, 3138], '1753-1758Crossref': [632, 3139], '(620)': [635, 3142], 'capacity': [640], 'deplete': [648], 'total': [649, 4146], 'stores,': [652], 'particularly': [653, 3581], 'mitochondria,': [656], 'remains': [657], 'established': [660], '(4Yu': [661, 2517, 3170], '6Virag': [688, 2470, 3145, 3794], 'Immunol.': [695, 1229, 2477, 3152, 3801], '1998;': [696, 1230, 1273, 1306, 1438, 2478, 3153, 3553, 3802, 3883, 4070], '161:': [697, 1231, 2479, 3154, 3803], '3753-3759PubMed': [698, 1232, 2480, 3155, 3804], 'Because': [701, 2923], 'addition': [703, 3821], 'being': [705], 'nuclei,': [709], 'ADP-ribosyltransferases': [713], 'prevalent': [716], '(7Mosgoeller': [719, 2732], 'W.': [720, 2733, 2815], 'Steiner': [721, 2734], 'Hozak': [723, 2736], 'Penner': [725, 2738], 'E.': [726, 1237, 1247, 1265, 1298, 1430, 2687, 2739, 3252, 3283, 3312, 3355], 'Wesierska-Gadek': [727, 2740], 'Cell': [730, 2283, 2743], '109:': [733, 2746], '409-418Crossref': [734, 2747], '8Burzio': [738, 2751], 'L.O.': [739, 2752], 'Saez': [740, 2753], 'Cornejo': [742, 2755], 'Biochem.': [744, 796, 1870, 2757], 'Biophys.': [745, 2758], 'Res.': [746, 1396, 2759, 2914, 2956, 3882], 'Commun.': [747, 1397, 2760], '1981;': [748, 2761], '103:': [749, 2762], '369-375Crossref': [750, 2763], '(22)': [753, 2766], '9Masmoudi': [756], 'Islam': [758], 'F.': [759, 1100, 1337, 1591, 1636, 2023, 3448, 4014], 'Mandel': [760, 794], 'Neurochem.': [763, 1110, 1347, 1601, 1646, 2033, 2128, 2821, 2968, 3458], '1988;': [764], '51:': [765], '188-193Crossref': [766], '(29)': [769], 'Scholar),': [771, 821, 1654, 3638, 3806, 3890, 3927], 'where': [772, 961, 3717, 4165], 'similar': [773], 'nuclear': [775, 1024, 2497, 2512, 2989, 3902, 3954, 4143], 'PARP-1,': [776, 2498], 'they': [777], 'facilitate': [778], 'repair': [780, 3829], 'damage': [785, 2495, 2729], '(10Masmoudi': [786], 'el-Fetouaki': [788], 'Weltin': [790], 'D.': [791, 3615], 'Belhadj': [792], 'O.': [793], 'Mol.': [797, 1398, 2694, 3628], 'Biol.': [798, 2837, 2889, 3629], 'Int.': [799, 2969], '1993;': [800, 2839], '29:': [801, 2971], '77-83PubMed': [802], '11Druzhyna': [805, 2769], 'N.': [806, 2770, 2907, 3242, 3273, 3289, 3318, 3351, 3373, 3831], 'Smulson': [807, 2771, 3832], 'M.E.': [808, 2772, 3833], 'LeDoux': [809, 2773, 2832, 2908, 3834], 'S.P.': [810, 2774, 2833, 2909, 3835], 'Wilson': [811, 2775, 2834, 2910, 3836], 'G.L.': [812, 2776, 2835, 2911, 3837], 'Diabetes.': [813, 2777, 3838], '2000;': [814, 2778, 3342, 3839], '49:': [815, 2779, 3840], '1849-1855Crossref': [816, 2780, 3841], '(26)': [819, 2783, 3844], 'we': [822, 845, 3412], 'hypothesized': [823], 'may': [829, 3531, 3570, 3678, 3930, 3972], 'play': [830], 'pivotal': [832], 'survival': [837], 'under': [838, 934, 2107, 2379, 2933, 3016], 'excitotoxicity.Here': [844], 'show': [846, 3472], 'preserves': [852, 2593, 2620], '(ΔΨm)': [856], 'content,': [859], 'maintains': [860], 'reduces': [864, 1960], 'or': [872, 878, 1023, 1131, 1178, 1212, 1314, 1356, 1359, 1363, 1365, 1369, 1451, 1468, 1777, 2168, 2190, 2383, 2396, 3487, 3692], 'excitotoxicity.': [873], 'liposome-encapsulated': [876], 'ATP': [879, 1364, 1374], 'suggesting': [886, 4139], 'cells': [888, 1188, 1460, 1520, 2289, 2323, 2641, 3479, 4051], 'rescued': [892], 'repletion': [895, 2635], 'after': [896, 2612, 2856, 3495, 3504], 'Our': [899], 'findings': [900, 949], 'depletion': [904, 2658, 3020], 'convert': [908], 'death,': [922], 'providing': [923, 2948], 'unifying': [925], 'which': [928, 1959], 'regulate': [931, 3931], 'dysfunction,': [938, 4125], 'identifying': [940], 'multiple': [941], 'intracellular': [942], 'targets': [943], 'inhibitors': [945], 'poly(ADP-ribosylation).': [947], 'have': [950, 3413], 'relevance': [951], 'acute': [954], 'chronic': [956], 'contributing': [966, 4150], 'including': [968, 3901], 'stroke,': [969], 'traumatic': [970], 'brain': [971, 2114], 'injury,': [972, 2508], 'seizures,': [973], "Parkinson's": [975], 'disease': [976], 'neurondegenerative': [979], '(12Virag': [981], 'Pharmacol.': [985, 1272, 1400, 2695], 'Rev.': [986], '54:': [988], '375-429Crossref': [989], '(1216)': [992], '13Dawson': [995], 'New': [999], 'Horiz.': [1000], '1995;': [1001, 1250], '86-92Google': [1003], 'Scholar).EXPERIMENTAL': [1004], 'PROCEDURESPARP': [1005], 'ActivityPARP': [1006], 'enzyme': [1007], 'activity': [1008, 2563], 'was': [1009, 1064, 1172, 1185, 1658, 1700, 1781, 1793, 1797, 1972, 1988, 2006, 2089, 2100, 2139, 2170, 2199, 2358, 3509, 3519], 'measured': [1010, 1803, 1856], 'using': [1011, 1377, 1563, 1660, 1702, 1811, 1835, 1862, 1990, 2051, 2292, 2367], 'commercial': [1013], 'kit': [1014], '(Trevigen,': [1015], 'Gaithersburg,': [1016], 'MD).': [1017], 'Briefly,': [1018, 2042], '1': [1019, 1513, 1547, 1758, 2157, 2302, 2320], 'μg': [1020], 'protein': [1025, 2252], 'extracts': [1026], 'incubated': [1028, 1495, 1523, 1756], 'reaction': [1030, 1932, 1971, 2150, 2165], 'buffer': [1031, 1165, 1784, 1889, 2151, 2274, 2308, 2346, 2357], 'containing': [1032, 1508, 1785, 1808, 1890, 1934], 'histones': [1033], '[32P]NAD': [1035], '±': [1036], 'exogenous': [1037], 'strand': [1040], 'breaks.': [1041], 'After': [1042, 2350], 'incubating': [1043], 'at': [1044, 1549, 1695, 1768, 1922, 1925, 1950, 1983, 2068, 2091, 2217, 2227, 2233, 2347, 3006], 'room': [1045], 'temperature': [1046], '10': [1048, 1207, 1920, 2231], 'min,': [1049, 1168, 1789, 1906, 2185, 2225, 2352], 'reactions': [1050], 'terminated': [1052], 'proteins': [1054, 1612], 'precipitated': [1056], '20%': [1058, 1179, 1315], 'trichloroacetic': [1059], 'acid.': [1060], 'Incorporation': [1061], '32P': [1063], 'determined': [1065, 1701, 1982, 2206], 'scintillation': [1067], 'counting.Cell': [1068], 'Cultures': [1069, 1209], 'Pharmacological': [1071], 'StudiesPrimary': [1072], 'neuron-enriched': [1074], 'cultures': [1075, 1152], 'prepared': [1077, 1376, 2047], '16': [1079], '17-day-old': [1081], 'Sprague-Dawley': [1082, 2112], 'rat': [1083, 2113], 'embryos': [1084, 1412], 'described': [1086, 1577, 1622, 2009, 2122, 2278], '(14Zhang': [1087, 1324, 1578, 1623, 2010, 3435], 'X.': [1088, 1325, 1579, 1624, 2011, 3436, 4029], 'Chen': [1089, 1326, 1580, 1625, 2012, 3437], 'Du': [1093, 1330, 1584, 1629, 2016, 3441], 'Draviam': [1097, 1334, 1588, 1633, 2020, 3445], 'Guo': [1099, 1336, 1590, 1635, 2022, 3447], 'Nathaniel': [1101, 1338, 1592, 1637, 2024, 3449], 'Watkins': [1105, 1342, 1596, 1641, 2028, 3453], 'S.C.': [1106, 1343, 1597, 1642, 2029, 3454], '82:': [1112, 1349, 1603, 1648, 2035, 3460], '181-191Crossref': [1113, 1350, 1604, 1649, 2036, 3461], '(228)': [1116, 1353, 1607, 1652, 2039, 3464], 'Dissociated': [1119], 'suspensions': [1121, 2214], 'placed': [1123, 1898, 2163, 2176], '96-well': [1125, 1190, 1449], 'plates': [1126, 1450], '(5': [1127], '×': [1128, 1139, 2321], '104': [1129], 'cells/well)': [1130], 'plastic': [1133, 1453], 'dishes': [1134, 1454], 'coated': [1135], 'poly-d-lysine': [1137], '(1.3': [1138], '107': [1140], 'cells/well).': [1141], 'Experiments': [1142], 'performed': [1144, 1659, 1834, 2007], 'between': [1145, 3674], '7': [1146], '12': [1148], 'days': [1149], 'vitro.ONOO−Neuron-enriched': [1151], 'exposed': [1154, 1193, 1462, 3649], '100–250': [1156], 'μm': [1157, 1200, 1465, 1471, 2188], 'ONOO−': [1158, 1466, 1786, 1792, 2189, 2198, 2491, 2879, 2952, 3434, 3486, 3496, 3673], '(Cayman': [1159, 1176], 'Chemical,': [1160], 'Ann': [1161], 'Arbor,': [1162], 'MI)': [1163], '30': [1167, 1484], 'whereupon': [1169, 1790], 'fresh': [1170], 'media': [1171, 1184, 1205, 1780, 1796], 'replaced.SIN-1—2': [1173], 'mm': [1174, 2310, 2315, 2318], 'SIN-1': [1175], 'Chemical)': [1177], 'Me2SO': [1180, 1316], 'vehicle': [1181, 2169, 2192], 'culture': [1183, 1204], 'added': [1186, 1929, 2171, 2359], 'plates.GlutamateCells': [1191], 'varying': [1195], 'concentrations': [1196, 1992], 'ofl-glutamate': [1197], '5': [1199, 1788, 1905, 1914, 1977, 2224, 2327, 2334], 'glycine': [1201], '(Sigma)': [1202], 'min.': [1208, 1915], 'pre-': [1211], 'post-': [1213], 'treated': [1214], 'either': [1216], 'PARP': [1218, 1669, 2387, 2562, 2663, 2854, 3475, 3642, 3714], 'inhibitor': [1219, 3476], '(INH2BP)': [1221], '(6Virag': [1222], 'Scholar,15Bauer': [1234], 'P.I.': [1235], 'Kirsten': [1236], 'Varadi': [1238], 'Young': [1240], 'L.J.': [1241], 'Hakam': [1242], 'Comstock': [1244], 'J.A.': [1245, 1395, 4037], 'Kun': [1246, 1264, 1297, 1429], 'Biochimie': [1248], '(Paris).': [1249], '77:': [1251], '374-377Crossref': [1252], '(23)': [1255], '16Endres': [1258], 'Scott': [1260, 1287, 1419], 'G.S.': [1261, 1288, 1420], 'Moskowitz': [1266], 'M.A.': [1267, 4027], 'Eur.': [1270], '351:': [1274], '377-382Crossref': [1275], '(48)': [1278], '17Szabo': [1281], 'Cuzzocrea': [1285, 1417], 'Hake': [1289, 1421], 'M.P.': [1292, 1424], '95:': [1307, 1439], '3867-3872Crossref': [1308, 1440], '(278)': [1311, 1443], 'Scholar)': [1313, 1355, 1445, 1878, 2847, 4022], 'vehicle,': [1317, 1358], 'metalloporphyrin-based': [1319], 'decomposition': [1321], 'catalyst': [1322], 'FP15': [1323], 'PBS': [1357, 1490, 1507, 2262], 'liposomally': [1360], 'encapsulated': [1361], 'vehicles': [1366], '(empty': [1367], 'liposomes': [1368], 'buffer).': [1370], 'Liposomal': [1371], 'modification': [1379], 'thin-film': [1382], 'method': [1383, 1861], '(18Han': [1384], 'Y.Y.': [1385, 3381], 'Huang': [1386], 'Jackson': [1388], 'E.J.': [1389], 'Dubey': [1390], 'R.K.': [1391], 'Gillepsie': [1392], 'D.G.': [1393], 'Carcillo': [1394], 'Pathol.': [1399], '2001;': [1401, 1724, 2129, 2696, 3391], '110:': [1402], '107-116PubMed': [1403], 'Scholar).Fibroblasts': [1405], 'PARP-1−/−': [1407], 'corresponding': [1409], 'PARP+/+': [1410], 'mouse': [1411], '(17Szabo': [1413], 'cultured': [1447], 'confluence.': [1456], 'For': [1457, 2248], 'cytotoxicity': [1458, 2285, 3659], 'experiments': [1459], '250': [1464], 'without': [1469], '100': [1470, 2340], 'INH2BP.Immunocytochemistry': [1472], 'Confocal': [1474], 'MicroscopyNeurons': [1475], 'grown': [1476, 1751], 'on': [1477, 1752, 2063], 'poly-d-lysine-coated': [1478], 'glass': [1479], 'coverslips': [1480, 1754, 1846], 'fixed': [1482], 'min': [1485, 1767, 1921, 1978, 2232], '2%': [1487, 1502], 'paraformaldehyde': [1488], '(pH': [1491, 1894], '7.4).': [1492], 'Cells': [1493, 1560, 1750, 1771, 1881], '5%': [1497], 'normal': [1498], 'donkey': [1499], 'serum': [1500, 1504], 'bovine': [1503], 'albumin': [1505], '0.2%': [1509], 'Triton': [1510], 'X-100': [1511], 'h': [1514, 1548], 'permeabilize': [1516], 'membranes.': [1518], 'then': [1522, 1907, 1928, 2186], '1:100': [1526], 'dilution': [1527, 1540], 'rabbit': [1529], 'polyclonal': [1530], 'anti-HSP60': [1531], '(StressGen,': [1532], 'Victoria,': [1533], 'British': [1534], 'Columbia,': [1535], 'Canada)': [1536], '1:200': [1539], '(Biomol,': [1543], 'Reading,': [1544, 1667], 'PA)': [1545], '37': [1550, 1769, 2179], '°C,': [1551, 1927, 2235], 'followed': [1552, 2504], 'incubation': [1554], 'appropriate': [1557], 'secondary': [1558, 2506], 'antibody.': [1559], 'examined': [1562], 'Leica': [1565], 'TCS': [1566], 'NT': [1567], 'confocal': [1568], 'tri-laser': [1569, 2369], 'scanning': [1570], 'inverted': [1571], 'microscope': [1572, 1815], '(Wetzlar,': [1573], 'Germany)': [1574], 'previously': [1576, 3414], 'Scholar).Western': [1609], 'Blot': [1610], 'AnalysisCellular': [1611], 'separated': [1614, 2062], 'into': [1615], 'mitochondrial,': [1616], 'nuclear,': [1617], 'cytosolic': [1619, 2943], 'Western': [1656], 'blotting': [1657], 'antibodies': [1662], 'against:': [1663], 'polymers': [1665], '(BioMol,': [1666], 'PA),': [1668], '(Cell': [1670], 'Signaling,': [1671], 'Beverly,': [1672], 'MA),': [1673], 'carboxyl': [1675], 'terminus': [1676], '(AIF)': [1680], '(Santa': [1681], 'Cruz,': [1682, 1684], 'Santa': [1683], 'CA),': [1685], 'cytochrome': [1686], 'c': [1687], '(BD': [1688, 1693], 'Pharmingen),': [1689], 'cytochromec': [1691], 'oxidase': [1692], 'Pharmingen)': [1694], 'optimized': [1696], 'dilutions.Assessment': [1697], 'ΔΨmΔΨm': [1699], '5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolocarbocyanine': [1703], '(JC-1),': [1705], 'cationic': [1707], 'dye': [1708], 'accumulates': [1710], 'membrane': [1715], 'potential-dependent': [1716], 'manner': [1717], '(19Buckman': [1718], 'J.F.': [1719], 'Reynolds': [1720, 2125], 'I.J.': [1721, 2126], 'Neurosci.': [1723, 2716, 4016], '21:': [1725], '5054-5065Crossref': [1726], 'Data': [1730], 'presented': [1732], 'green': [1735], '(488/580': [1736], 'nm)/red': [1737], '(535/610': [1738], 'nm)': [1739], 'fluorescence': [1740], 'intensity': [1741], 'ratio,': [1742], 'increased': [1745], 'ratio': [1746], 'representing': [1747], 'depolarization.': [1749], 'collagen-coated': [1753], 'μg/ml': [1759, 2335], 'JC-1': [1760], '(Molecular': [1761], 'Probes,': [1762], 'Eugene,': [1763], 'OR)': [1764], '20': [1766, 2072, 2254, 2351], '°C.': [1770, 2349], 'pretreated': [1773], 'INH2BP,': [1775], 'FP-15,': [1776], 'vehicle.': [1778], 'replaced': [1782], 'removed': [1794, 2216], 'replaced.': [1798], 'Green/red': [1799], 'fluorescent': [1800], 'ratios': [1801], 'five': [1805], 'predefined': [1806], 'fields': [1807], '2–5': [1809], 'cells/field': [1810], 'Olympus': [1813], 'IX70': [1814], '×60': [1818], 'oil': [1819], 'immersion': [1820], '1.4': [1821], 'numerical': [1822], 'aperature': [1823], 'optic': [1824], 'automated': [1827], 'stage.': [1828], 'Image': [1829], 'acquisition': [1830], 'analysis': [1832], 'Simple': [1836], 'PCI': [1837], '(Compix,': [1838], 'Inc.,': [1839], 'Cranberry,': [1840], 'PA).': [1841], 'A': [1842, 1985], 'minimum': [1843], '2': [1845], 'imaged': [1848], 'per': [1849], 'condition.Determination': [1850], 'NAD+Cellular': [1852], 'levels': [1854, 1997], 'enzymatic': [1859], 'cycling': [1860], 'alcohol': [1863, 1942], 'dehydrogenase': [1864], '(20Nisselbaum': [1865], 'J.S.': [1866], 'Green': [1867], 'Anal.': [1869], '1969;': [1871], '27:': [1872, 2916], '212-217Crossref': [1873], '(187)': [1876], 'modifications.': [1880], 'homogenized': [1883, 2271], '0.05': [1885], 'm': [1886, 1892, 1938], 'K': [1887], 'phosphate': [1888], '0.1': [1891, 1937], 'nicotinamide': [1893], '6.0),': [1895], 'frozen': [1896, 2242], 'rapidly,': [1897], 'boiling': [1901], 'water': [1902, 2181], 'bath': [1903, 1912, 2182], 'cooled': [1908], 'ice': [1911], 'Samples': [1916], 'centrifuged': [1918, 2226], '1,000': [1923], 'rpm': [1924, 2229], '4': [1926, 2234, 2348], 'mixture': [1933], '0.065': [1935], 'mglycylglycine,': [1936], 'nicotinamide,': [1939], '0.5': [1940], 'methanol,': [1941], 'dehydrogenase,': [1943], '(MTT),': [1946], 'phenazine': [1948, 1966], 'methosulfate': [1949, 1967], 'pH': [1951, 2312], '7.4.': [1952], 'sample': [1956], 'generates': [1957], 'NADH,': [1958], 'MTT': [1961], 'through': [1962], 'intermediation': [1964], 'formazan.': [1969], 'allowed': [1973], 'run': [1975], 'absorbance': [1981], 'A556.': [1984], 'standard': [1986], 'curve': [1987], 'generated': [1989, 2878], 'known': [1991], 'calculated.Pulsed': [1999], 'Field': [2000, 2074], 'Gel': [2001], 'ElectrophoresisPulsed': [2002], 'field': [2003], 'gel': [2004, 2067, 2099], 'electrophoresis': [2005], 'chromosomal': [2043], 'samples': [2045, 2364], 'agarose': [2049, 2066], 'plugs': [2050], 'CHEF': [2053], 'Mammalian': [2054], 'Genomic': [2055], 'Plug': [2057], 'Kit': [2058], '(Bio-Rad).': [2059], 'Fragments': [2060], '1.2%': [2065], '14': [2069], '°C': [2070, 2180], 'h.': [2073], 'strengths': [2075], '180': [2077], 'V': [2078, 2082, 2306, 2344, 3501, 3522], 'forward': [2079], '120': [2081], 'reverse,': [2083], 'initial': [2084], 'final': [2086, 2154], 'switching': [2087], 'time': [2088, 2221], 'set': [2090], '5–60': [2092], 's': [2093], 'linear': [2096], 'ramp.': [2097], 'stained': [2101, 2325], 'ethidium': [2103], 'visualized': [2106], 'UV': [2108], 'light.Isolated': [2109], 'Brain': [2110, 2955], 'MitochondriaAdult': [2111], 'isolated': [2117, 2212], 'differential': [2119], 'centrifugation': [2120], '(21Votyakova': [2123], 'T.V.': [2124], '79:': [2130], '266-277Crossref': [2131], '(507)': [2134], 'Mitochondrial': [2137, 2268], 'viability': [2138], 'measuring': [2142], 'oxygen': [2143, 2868], 'consumption.': [2144], 'Mitochondria': [2145], 'suspended': [2147], 'concentration': [2155, 2196], 'mg': [2158], 'protein/ml': [2161], 'tubes.': [2166], 'Drug': [2167], '15': [2184], '750': [2187], 'pH-adjusted': [2191], 'added.': [2194], 'This': [2195, 3579], 'found': [2200], 'completely': [2202], 'depolarize': [2203], 'Safranin-O.': [2208], 'Aliquots': [2209], 'baseline': [2218], '(−15': [2219], 'min),': [2220], '0': [2222], '14,000': [2228], 'pellets': [2238, 2269], 'supernatants': [2240, 2258], 'stored': [2244], 'batch': [2246], 'analysis.': [2247], 'assessment': [2249], 'μl': [2255, 2328, 2341, 2354], 'dialyzed': [2260], 'against': [2261], 'mini-dialysis': [2265], 'device': [2266], '(Pierce).': [2267], 'lysis': [2273], 'handled': [2276], 'above.Flow': [2279], 'Cytometric': [2280], 'Analysis': [2281], 'DeathFollowing': [2284], 'drug': [2287], 'treatments,': [2288], 'harvested': [2291], 'trypsin-EDTA,': [2293], 'washed': [2294], 'once': [2295], 'ice-cold': [2297], 'PBS,': [2298], 'resuspended': [2300], 'ml': [2303], 'Annexin': [2305, 2330, 2343, 3500], 'binding': [2307, 2345, 2356], '(10': [2309], 'Hepes,': [2311], '7.4,': [2313], '140': [2314], 'NaCl,': [2316], '2.5': [2317], 'CaCl2).': [2319], '105': [2322], 'V-fluorescein': [2331], 'isothiocyanate': [2332], '(PI)': [2338], '400': [2353], 'each': [2361], 'tube': [2362], 'analyzed': [2366], 'FACS': [2370], 'Calibur': [2371], 'flow': [2372], 'cytometer.DISCUSSIONWhereas': [2373], 'homeostasis': [2378], 'basal': [2380, 2590], 'conditions,': [2381], 'pharmacological': [2382], 'genetic': [2384], 'stress,': [2392, 2398], 'e.g.': [2393], 'beneficial': [2400, 2851], '(2Eliasson': [2401, 3725], 'Under': [2483], 'circumstances,': [2485], 'proposed': [2489], 'produces': [2492, 2551], 'activating': [2496], 'subsequent': [2500], 'AIF': [2509, 3166, 4129, 4173], 'translocation,': [2513], 'our': [2545], 'dysfunction': [2553, 4153], 'directly': [2554, 2670], 'promoting': [2556], 'rapid': [2557, 2850], 'loss': [2558, 4121], 'ΔΨm.': [2560], 'Intramitochondrial': [2561], 'limited': [2567, 3722], 'stores': [2570, 3588, 3720, 4149], 'related': [2571, 3656, 3680], 'impaired': [2573], 'NAD': [2574], 'recycling': [2575], 'would': [2576], 'exacerbate': [2577], 'consuming': [2581], 'NAD+directly.': [2583], 'In': [2584, 2861, 3467, 3820, 3969, 4049], 'support': [2585, 3963], 'this,': [2587], 'ΔΨm,': [2594, 4123], 'NAD+levels,': [2595], 'prevents': [2599], 'AIF,': [2603], 'attenuates': [2605], 'large-scale': [2606, 3227], 'fragmentation': [2608, 3230], 'replenishment': [2616], 'respiration.': [2624], 'indicate': [2627], 'represent': [2636, 4161], 'effective': [2637], 'strategies': [2638], 'protect': [2640, 2671, 3426], 'face': [2644, 4180], 'insults': [2646], 'producing': [2647], 'failure,': [2649], 'consistent': [2652, 3701], 'presumption': [2655], 'PARP-related': [2661], 'cytotoxicity.': [2662], 'shown': [2668], 'electron': [2672], 'transport': [2673], 'chain': [2674], 'complexes': [2675], 'inactivation': [2677], 'induced': [2678, 3432, 3484], '(24Halmosi': [2682], 'Berente': [2684], 'Z.': [2685, 2811, 3623], 'Osz': [2686], 'Toth': [2688], 'Literati-Nagy': [2690], 'Sumegi': [2692], '59:': [2697], '1497-1505Crossref': [2698], '(124)': [2701], 'Similarly,': [2704], 'NO': [2705], 'inhibits': [2706], 'metabolism': [2708], '(25Brorson': [2709], 'J.R.': [2710], 'Schumacker': [2711], 'P.T.': [2712], 'Zhang': [2713, 4028], '147-158Crossref': [2719], 'Scholar).Compartmentalization': [2722], 'active': [2724], 'PARP,': [2725], 'NAD+,': [2726], '26Yakes': [2786], 'F.M.': [2787], 'Van': [2788], 'Houten': [2789], '94:': [2799], '514-519Crossref': [2800], '(1425)': [2803], '27Lee': [2806], 'H.M.': [2807], 'Hu': [2810], 'Greeley': [2812], 'G.H.': [2813], 'Makalowski': [2814], 'Hellmich': [2816], 'H.L.': [2817], 'Englander': [2818], 'E.W.': [2819], '80:': [2823], '928-937Crossref': [2824], '(36)': [2827], '28Driggers': [2830], 'Chem.': [2838, 2890], '268:': [2840], '22042-22045Abstract': [2841], 'Full': [2842, 2894, 2896], 'Text': [2843, 2895, 2897], 'PDF': [2844, 2898], 'explain': [2848], 'effects': [2852], 'exposure': [2857, 3506], 'extramitochondrial': [2859], 'ONOO−.': [2860], 'addition,': [2862], 'compartmentalization': [2863], 'synthase': [2866, 2926, 2947], 'radicals': [2869], 'source': [2875], 'internally': [2877], '(29Ghafourifar': [2880], 'Schenk': [2882], 'Klein': [2884], 'S.D.': [2885], 'Richter': [2886], '274:': [2892], '31185-31188Abstract': [2893], '(306)': [2901], '30Grishko': [2904], 'V.I.': [2905], 'Druzhyna': [2906], 'Nucleic': [2912, 3880], 'Acids': [2913, 3881], '4510-4516Crossref': [2917], '(52)': [2920], 'calcium-dependent,': [2928], 'elevations': [2929], 'occurring': [2932], 'excitotoxicity': [2936], 'could': [2937], 'result': [2938], 'two': [2949], 'sources': [2950], '(31Szabo': [2953], 'Bull.': [2957], '41:': [2959], '131-141Crossref': [2960], '32Dawson': [2964], '97-110Crossref': [2972], '(171)': [2975], 'results': [2979], 'study': [2982], 'do': [2983, 3424, 4134, 4160], 'not': [2984, 3425, 3541, 3654, 4135], 'discount': [2985], 'importance': [2987], 'terms': [2993], 'consumption;': [2997], 'however,': [2998, 3159, 3220, 3561], 'apparent': [3001], 'least': [3007], 'part': [3009], 'determination': [3012], 'fate': [3015], 'circumstances': [3017], 'failure.Traditionally,': [3023], 'PARP-mediated': [3024], 'felt': [3029, 3407], 'necrotic': [3033, 3400], 'nature': [3035], '5Szabo': [3122], 'Recently,': [3158], 'PARP-regulated': [3160], 'programmed': [3161, 3198, 3403], 'mediated': [3164], 'identified': [3169], 'AIF-mediated': [3197, 3402, 3429, 3481], 'many': [3202, 3815, 3898], 'phenotypic': [3203], 'features': [3204], 'developmental': [3206], 'apoptosis': [3207, 3530], 'such': [3208, 3225, 3964, 4052], 'fragmentation,': [3211], 'phosphatidylserine': [3212], 'exposure,': [3213], 'regulation': [3215], 'bcl-2': [3217], 'family': [3218], 'proteins;': [3219], 'differences': [3222, 3653], 'exist,': [3224], 'versusoligonucleosomal': [3228], 'progresses': [3235], 'despite': [3236], 'caspase': [3237, 3418], '(33Susin': [3239], 'S.A.': [3240, 3269, 3310, 3353], 'Zamzami': [3241, 3272, 3317, 3372], 'Castedo': [3243], 'Hirsch': [3245], 'T.': [3246, 3326, 3363, 4002, 4068], 'Marchetti': [3247], 'Macho': [3249], 'Daugas': [3251, 3311, 3354], 'Geuskens': [3253], 'Kroemer': [3255, 3298, 3337, 3386], 'Exp.': [3258, 3340, 3600], '184:': [3261], '1331-1341Crossref': [3262], '(1028)': [3265], '34Susin': [3268], 'Lorenzo': [3270], 'H.K.': [3271], 'Marzo': [3274], 'I.': [3275, 4063], 'Snow': [3276], 'B.E.': [3277], 'Brothers': [3278, 3329], 'G.M.': [3279], 'Mangion': [3280], 'Jacotot': [3282], 'Costantini': [3284, 3321], 'Loeffler': [3286, 3319], 'Larochette': [3288], 'Goodlett': [3290], 'D.R.': [3291], 'Aebersold': [3292], 'Siderovski': [3294], 'D.P.': [3295], 'Penninger': [3296, 3333, 3388], 'J.M.': [3297, 3389], 'Nature.': [3300, 3390], '397:': [3302], '441-446Crossref': [3303], '(3431)': [3306], '35Susin': [3309], 'Ravagnan': [3313, 3368], 'Samejima': [3315], 'Ferri': [3323, 3370], 'K.F.': [3324, 3371], 'Irinopoulou': [3325], 'Prevost': [3327], 'M.C.': [3328], 'Mak': [3331, 3382], 'T.W.': [3332, 3383], 'Earnshaw': [3335], 'W.C.': [3336], '192:': [3343], '571-580Crossref': [3344], '(660)': [3347], '36Joza': [3350], 'Susin': [3352], 'Stanford': [3356], 'W.L.': [3357], 'Cho': [3358], 'S.K.': [3359], 'Li': [3360], 'C.Y.': [3361], 'Sasaki': [3362], 'Elia': [3364], 'A.J.': [3365], 'Cheng': [3366], 'H.Y.': [3367], 'Wakeham': [3374], 'Hakem': [3376], 'Yoshida': [3378], 'Kong': [3380], 'Zuniga-Pflucker': [3384], 'J.C.': [3385], '410:': [3392], '549-554Crossref': [3393], '(1148)': [3396], 'Both': [3399], 'caspase-independent,': [3410], 'reported': [3415], 'inhibitorsN-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone': [3419], '(VAD)': [3420], 'boc-Asp(OMe)-fluromethylketone': [3422], '(BAF)': [3423], 'contrast,': [3468], 'present': [3470], 'INH2BP': [3477, 3490], 'protects': [3478], 'glutamate.': [3488], 'Whereas': [3489], 'apoptotic': [3492], '(PI': [3497, 3511], 'extrusion': [3498], 'binding;': [3502], 'Fig.4c),': [3503], 'extrusion;': [3512], 'Fig.': [3513], '6c)': [3514], 'but': [3515, 3662], 'pre-apoptotic': [3517], 'phenotype': [3518], 'expressed': [3520], '(PI−/Annexin': [3521], 'binding)': [3523], 'neurons.': [3525], 'concept': [3527], 'preventing': [3529, 3568], 'switch': [3532, 3571], 'mode': [3534, 3573], 'necrosis': [3539, 3569, 3646], 'novel': [3542], '(37Lemaire': [3543], 'Andreau': [3545], 'Souvannavong': [3547], 'Adam': [3549], 'FEBS': [3551], 'Lett.': [3552], '425:': [3554], '266-270Crossref': [3555], '(167)': [3558], 'Scholar);': [3560], 'possibility': [3566], 'apoptosis.': [3578], 'concept,': [3580], 'paradigms': [3583], 'conserve': [3585], '(38Leist': [3589], 'Single': [3591], 'Castoldi': [3593], 'A.F.': [3594], 'Kuhnle': [3595], 'Nicotera': [3597], '185:': [3603], '1481-1486Crossref': [3604], '(1636)': [3607], '39Los': [3610], 'Mozoluk': [3612], 'Ferrari': [3614], 'Stepczynska': [3616], 'Stroh': [3618], 'Renz': [3620], 'Herceg': [3622], 'Schulze-Osthoff': [3626, 3856], 'Cell.': [3630], '13:': [3632], '978-988Crossref': [3633], '(384)': [3636], 'warrants': [3639], 'further': [3640], 'study.': [3641], 'ONOO−,': [3651], 'demonstrating': [3652], 'only': [3655], 'paradigm': [3660, 4163], 'chosen,': [3661], 'type': [3667], 'used.': [3668], 'Differences': [3669], 'dividing': [3682, 4050], 'versus': [3683], 'non-dividing': [3684], 'immortalizedversus': [3686], 'cultures,': [3689], 'density,': [3691], 'factors.': [3694], 'Nonetheless,': [3695], 'taken': [3696], 'together': [3697], 'caspase-independent': [3709], 'death.Whereas': [3711], 'times': [3716], 'detrimental': [3724], 'remember': [3811], 'serves': [3814, 3893], 'functions': [3817, 3966], 'well.': [3819], 'facilitating': [3823], '(11Druzhyna': [3830], 'Scholar,40Wang': [3846], 'Stingl': [3848], 'Morrison': [3850], 'Jantsch': [3852], 'Los': [3854], 'Wagner': [3858], 'E.F.': [3859], 'Genes': [3860], 'Dev.': [3861], '11:': [3863], '2347-2358Crossref': [3864], '(513)': [3867], '41Trucco': [3870], 'Oliver': [3872], 'F.J.': [3873], 'de': [3874, 4066], 'Murcia': [3875, 3878], 'Menissier-de': [3877], '26:': [3884], '2644-2649Crossref': [3885], '(309)': [3888], 'regulatory': [3895], 'factors': [3900], 'factor-κB,': [3903], 'AP-1,': [3904], 'Stat-1': [3906], '(42Ha': [3907], 'H.C.': [3908], 'Hester': [3909], 'L.D.': [3910], '99:': [3921], '3270-3275Crossref': [3922], '(223)': [3925], 'itself': [3933], 'loosening': [3935], 'chromatin': [3936], '(43Tulin': [3937], 'Spradling': [3939], '2003;': [3942, 4044], '299:': [3943], '560-562Crossref': [3944], '(381)': [3947], 'Baseline': [3950], 'compartments': [3957], 'demonstrated': [3959], 'study,': [3962], 'neurons,': [3970], 'participate': [3974], 'long-term': [3976], 'potentiation': [3977], '(44Schuman': [3978], 'E.M.': [3979], 'Meffert': [3980], 'M.K.': [3981], 'Schulman': [3982], 'Madison': [3984], 'D.V.': [3985], '91:': [3994], '11958-11962Crossref': [3995], '(123)': [3998], '45Kleppisch': [4001], 'Pfeifer': [4003], 'Klatt': [4005], 'Ruth': [4007], 'Montkowski': [4009], 'Fassler': [4011], 'Hofmann': [4013], '48-55Crossref': [4019], 'memory': [4024], '(46Satchell': [4026], 'Jenkins': [4034], 'L.W.': [4035], 'Melick': [4036], 'Neurochem.,.': [4043], '(in': [4045], 'press)PubMed': [4046], 'fibroblasts,': [4054], 'PARP-2': [4057], 'regulates': [4058], 'mitosis': [4059], '(47Smith': [4060], 'Giriat': [4062], 'Schmitt': [4064], 'Lange': [4067], '282:': [4071], '1484-1487Crossref': [4072], '(895)': [4075], 'nuclei': [4089], 'depletion.A': [4110], 'direct': [4111], 'implicated.': [4131], 'refute': [4136], 'previous': [4137], 'hypotheses': [4138], 'overactivation': [4141], 'consumes': [4145], 'shift,': [4164]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2153053799', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 18}, {'year': 2013, 'cited_by_count': 20}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-27T00:21:05.006406', 'created_date': '2016-06-24'}