Title: Large-cell neuroendocrine carcinoma of the major duodenal papilla: case report
Abstract: For many years, neoplasms of the disseminated neuroendocrine cell system of the GI tract have been subsumed as “carcinoids.” However, because these tumors have a broad morphologic and biologic spectrum, this is no longer adequate. 1. Kloppel G. Perren A. Heitz P.U. From carcinoids to neuroendocrine tumors: classification in the gastrointestinal tract and the pancreas. Dtsch Arztebl. 2003; 100 ([German]): A1932-A1942 Google Scholar Instead, the latest World Health Organization (WHO) classification (2000) recommends that these tumors be differentiated into 3 types: (1) well-differentiated endocrine tumor (carcinoid), (2) well-differentiated endocrine carcinoma (malignant carcinoid), and (3) poorly differentiated endocrine carcinoma (small-cell carcinoma). 2. Solcia E. Kloppel G. Sobin L.H. Histological typing of endocrine tumours. 2nd ed. Springer, Heidelberg2000 Crossref Google Scholar Large-cell neuroendocrine carcinoma (LCNEC) arising at the major duodenal papilla is extremely rare, and differential diagnosis with respect to other neuroendocrine tumors is difficult. 3. Cavazza A. Gallo M. Valcavi R. De Marco L. Gardini G. Large cell neuroendocrine carcinoma of the ampulla of vater. Arch Pathol Lab Med. 2003; 127: 221-223 PubMed Google Scholar , 4. Albores-Saavedra J. Henson D.E. Klimstra D.S. Atlas of tumor pathology: tumors of the gallbladder, extrahepatic bile ducts, and ampulla of Vater. Series. 3 ed. Armed Forces Institute of Pathology, Washington, DC2000 Google Scholar A case is presented that illustrates the difficulty of pre-operative diagnosis, different possibilities for treatment and follow-up, and, especially, pitfalls.
Publication Year: 2004
Publication Date: 2004-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 13
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot